Creatine monohydrate production system

Abstract

The utility model relates to the technical field of chemical engineering systems, in particular to a creatine monohydrate production system which comprises a creatine monohydrate separation device and a first polymer filter membrane device, the creatine monohydrate separation device is provided with a mother liquor discharge pipe, and the mother liquor discharge pipe is connected with an inlet of the first polymer filter membrane device. And the first polymer filtering membrane device is provided with a second byproduct discharging pipe and a circulating material discharging pipe. By-products filtered by the first polymer filtering membrane device are conveyed to a fertilizer production system through a second by-product discharging pipe to produce organic nitrogen fertilizer, the by-products are recycled, waste liquid discharge is reduced, and economic benefits are improved. The filtrate is conveyed to the creatine monohydrate reaction kettle through the circulating material discharging pipe to continue to participate in the reaction, so that the utilization rate of methylaminoacetonitrile, sodium sarcosinate and part of creatine monohydrate in the filtrate can be increased, and raw materials are saved.

Description

Technical Field

[0001] The utility model relates to the technical field of chemical systems, in particular to a creatine monohydrate production system. Background Art

[0002] Creatine monohydrate is a pharmaceutical raw material and health product additive. It can inhibit the occurrence of muscle fatigue factors, reduce fatigue and tension, restore physical strength, accelerate the synthesis of human protein, make muscles stronger, enhance muscle elasticity, reduce cholesterol, blood lipids and blood sugar levels, improve muscle atrophy in the elderly, and delay aging. Over the past 10 years, creatine monohydrate has been hailed as one of the most popular and effective nutritional supplements. Its status is high enough to be on par with protein products and firmly ranks among the "best-selling supplements". It is rated as a "must-use" product for bodybuilders, and is also widely used by athletes in other sports, such as football and basketball players, who want to improve their energy levels and strength. Creatine is not a banned drug. It is naturally present in many foods. Therefore, no sports organization prohibits the use of creatine. The current mainstream process is: the first-step reaction is the condensation reaction of hydroxyacetonitrile and monomethylamine to produce methylamine acetonitrile, with a reaction yield of about 92%; the second-step reaction is the hydrolysis reaction of methylamine acetonitrile and sodium hydroxide to produce sodium sarcosinate; the third-step reaction is the synthesis reaction of sodium sarcosinate and cyanamide to produce creatine, with a reaction yield of about 72%.

[0003] In the prior art, a Chinese invention patent with application number CN202210671609.6 discloses a method for preparing creatine monohydrate, comprising: introducing a sodium sarcosinate aqueous solution with a pH value greater than or equal to 12 into a bipolar membrane electrodialysis device, separating and removing the sodium ions therein to obtain a sodium sarcosinate aqueous solution with a pH value of 9 to 10 and a sodium hydroxide aqueous solution; placing the sodium sarcosinate aqueous solution with a pH value of 9 to 10 in a reactor, adding a cyanamide aqueous solution to react to generate creatine monohydrate under stirring and at a temperature of 70 to 90° C., cooling to precipitate creatine monohydrate crystals, and then performing solid-liquid separation, washing, separating, and drying the creatine monohydrate crystals to obtain creatine monohydrate; passing the mother liquor after solid-liquid separation and the washing liquid after washing the creatine monohydrate crystals into a bipolar membrane electrodialysis device to obtain an acidic mother liquor washing liquid and a sodium hydroxide solution; the acidic mother liquor washing liquid can be made into an organic fertilizer after concentration, and the sodium hydroxide aqueous solution can be reused after concentration. The acidic mother liquor washing liquid in this scheme also contains incompletely reacted methylaminoacetonitrile and sodium sarcosinate, as well as part of creatine monohydrate. Directly converting the acidic mother liquor washing liquid into organic fertilizer will cause waste of raw materials and increase production costs. Summary of the invention

[0004] Based on this, the present application provides a creatine monohydrate production system to solve the technical problems of waste of raw materials and increased production costs in the prior art.

[0005] The technical solution of this application to solve the above technical problems is as follows:

[0006] A creatine monohydrate production system, comprising:

[0007] A creatine monohydrate separation device, wherein the creatine monohydrate separation device is provided with a mother liquor discharge pipe;

[0008] The first polymer filtration membrane device, the mother liquid discharge pipe is connected to the inlet of the first polymer filtration membrane device, and the first polymer filtration membrane device is provided with a circulating material discharge pipe.

[0009] Preferably, the above-mentioned creatine monohydrate production system also includes a creatine monohydrate reactor, the outlet of the creatine monohydrate reactor is connected to the inlet of the creatine monohydrate separation device, and the circulating material discharge pipe is connected to the inlet of the creatine monohydrate reactor.

[0010] Preferably, the creatine monohydrate production system further comprises a sodium sarcosinate reactor, and the outlet of the sodium sarcosinate reactor is connected to the inlet of the creatine monohydrate reactor.

[0011] Preferably, the above-mentioned creatine monohydrate production system also includes a bipolar membrane electrodialysis device, the outlet of the sodium sarcosinate reactor is connected to the inlet of the bipolar membrane electrodialysis device, and the bipolar membrane electrodialysis device is provided with a sodium hydroxide recovery pipe and a first product discharge pipe, the sodium hydroxide recovery pipe is connected to the inlet of the sodium sarcosinate reactor, and the first product discharge pipe is connected to the inlet of the creatine monohydrate reactor.

[0012] Preferably, the above-mentioned creatine monohydrate production system also includes a second polymer filtration membrane device, the first product discharge pipe is connected to the inlet of the second polymer filtration membrane device, the second polymer filtration membrane device is provided with a first by-product discharge pipe and a second product discharge pipe, and the second product discharge pipe is connected to the inlet of the creatine monohydrate reactor.

[0013] Preferably, the above-mentioned creatine monohydrate production system also includes a fertilizer production system, and the first by-product discharge pipe is connected to the fertilizer production system.

[0014] Preferably, in the above-mentioned creatine monohydrate production system, the first polymer filtration membrane device is further provided with a second by-product discharge pipe, and the second by-product discharge pipe is connected to the fertilizer production system.

[0015] Preferably, in the above-mentioned creatine monohydrate production system, the creatine monohydrate separation device comprises a crystallization reactor and a centrifuge, the outlet of the creatine monohydrate reactor is connected to the inlet of the crystallization reactor, the outlet of the crystallization reactor is connected to the inlet of the centrifuge, the solid phase outlet of the centrifuge is the creatine monohydrate finished product outlet, and the liquid phase outlet of the centrifuge is connected to the mother liquor discharge pipe.

[0016] Preferably, in the above-mentioned creatine monohydrate production system, the inlet of the sodium sarcosinate reactor is further provided with a pH sensor, the sodium hydroxide recovery pipe is further provided with an electric valve, and the pH sensor and the electric valve are electrically connected.

[0017] Compared with the prior art, the present invention has at least the following advantages:

[0018] The creatine monohydrate production system of the present application includes a creatine monohydrate separation device and a first polymer filtration membrane device, and the creatine monohydrate separation device is provided with a mother liquor discharge pipe, and the mother liquor discharge pipe is connected to the import of the first polymer filtration membrane device, and the first polymer filtration membrane device has a second by-product discharge pipe and a circulating material discharge pipe. The by-product nitrogen content filtered by the first polymer filtration membrane device is as high as 15% to 30%, and is transported to the fertilizer production system through the second by-product discharge pipe to produce organic nitrogen fertilizer, and the by-product is reused, reducing waste liquid discharge and improving economic benefits. The content of organic matter in the filtrate is low, and the filtrate is transported to the creatine monohydrate reactor through the circulating material discharge pipe to continue to participate in the reaction, which can improve the utilization rate of methylaminoacetonitrile and sodium sarcosinate in the filtrate and part of creatine monohydrate, thereby saving raw materials. At the same time, the second polymer filtration membrane device is provided with a first by-product discharge pipe. The by-product filtered by the second polymer filtration membrane device is transported to the fertilizer production system through the first by-product discharge pipe to produce organic nitrogen fertilizer. The by-product is reused, waste liquid discharge is reduced, and economic benefits are improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 Schematic diagram of the structure of creatine monohydrate production system.

[0020] In the figure: creatine monohydrate separation device 100, mother liquor discharge pipe 110, crystallization reactor 120, centrifuge 130, first polymer filtration membrane device 200, circulating material discharge pipe 210, second by-product discharge pipe 220, creatine monohydrate reactor 300, sodium sarcosinate reactor 400, pH sensor 410, bipolar membrane electrodialysis device 500, sodium hydroxide recovery pipe 510, electric valve 511, first product discharge pipe 520, second polymer filtration membrane device 600, first by-product discharge pipe 610, second product discharge pipe 620, fertilizer production system 700. DETAILED DESCRIPTION

[0021] In order to facilitate the understanding of the present application, the present application will be described more fully below with reference to the relevant drawings. The preferred embodiments of the present application are given in the drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thoroughly and comprehensively understood.

[0022] It should be noted that when an element is referred to as being "disposed on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right", "top", "bottom", "bottom end", "top end" and similar expressions used herein are for illustrative purposes only and do not represent the only implementation method.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used in the specification herein are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0024] See also Figure 1 In one specific embodiment of the present application, a creatine monohydrate production system comprises:

[0025] A creatine monohydrate separation device 100 is provided with a mother liquor discharge pipe 110; a first polymer filtration membrane device 200, wherein the mother liquor discharge pipe 110 is connected to the inlet of the first polymer filtration membrane device 200, and the first polymer filtration membrane device 200 is provided with a circulating material discharge pipe 210.

[0026] The creatine monohydrate separation device 100 is used to cool, crystallize and separate the creatine monohydrate solution generated by the reaction in the previous process to obtain a solid creatine monohydrate product and a mother liquor. The mother liquor contains incompletely reacted methylaminoacetonitrile and sodium sarcosinate, as well as part of creatine monohydrate. The mother liquor is transported to the first polymer filtration membrane device 200 through the mother liquor discharge pipe 110. After filtering in the first polymer filtration membrane device 200, the content of organic matter in the filtrate (circulating material) is low. The filtrate is transported to the previous process through the circulating material discharge pipe 210 to continue to participate in the reaction, which can improve the utilization rate of methylaminoacetonitrile and sodium sarcosinate and part of creatine monohydrate in the filtrate, avoid the waste of incompletely reacted methylaminoacetonitrile and sodium sarcosinate in the mother liquor directly making fertilizer, thereby saving raw materials. The first polymer filtration membrane device 200 can select reverse osmosis membrane, ultrafiltration membrane, microporous membrane, nanofiltration membrane, microfiltration membrane, etc., and ultrafiltration membrane can be preferably selected in this scheme.

[0027] Furthermore, the above-mentioned creatine monohydrate production system further includes a creatine monohydrate reactor 300, the outlet of the creatine monohydrate reactor 300 is connected to the inlet of the creatine monohydrate separation device 100, and the circulating material discharge pipe 210 is connected to the inlet of the creatine monohydrate reactor 300. Sodium sarcosinate and cyanamide react in the creatine monohydrate reactor 300 to generate a creatine monohydrate solution, and the creatine monohydrate solution is transported from the outlet of the creatine monohydrate reactor 300 to the creatine monohydrate separation device 100. After the mother liquor separated by the creatine monohydrate separation device 100 is filtered by the first polymer filtration membrane device 200, the filtrate is transported to the creatine monohydrate reactor 300 through the circulating material discharge pipe 210 for reuse and participates in the reaction again.

[0028] In a specific embodiment of the present application, the above-mentioned creatine monohydrate production system further includes a sodium sarcosinate reactor 400, and the outlet of the sodium sarcosinate reactor 400 is connected to the inlet of the creatine monohydrate reactor 300. The methylaminoacetonitrile aqueous solution and the sodium hydroxide aqueous solution react in the sodium sarcosinate reactor 400 to generate a sodium sarcosinate aqueous solution, which is one of the raw materials for preparing creatine monohydrate and will be transported to the creatine monohydrate reactor 300 for reaction, so the outlet of the sodium sarcosinate reactor 400 is connected to the inlet of the creatine monohydrate reactor 300.

[0029] Preferably, the above-mentioned creatine monohydrate production system further includes a bipolar membrane electrodialysis device 500, the outlet of the sodium sarcosinate reactor 400 is connected to the inlet of the bipolar membrane electrodialysis device 500, and the bipolar membrane electrodialysis device 500 is provided with a sodium hydroxide recovery pipe 510 and a first product discharge pipe 520, the sodium hydroxide recovery pipe 510 is connected to the inlet of the sodium sarcosinate reactor 400, and the first product discharge pipe 520 is connected to the inlet of the creatine monohydrate reactor 300. Since the pH value of the sodium sarcosinate aqueous solution generated by the sodium sarcosinate reactor 400 is relatively large, usually greater than or equal to 12, and the pH value of the sodium sarcosinate aqueous solution required for the subsequent reaction should be between 9 and 10, it is necessary to adjust the sodium sarcosinate aqueous solution. Bipolar membrane is a new type of ion exchange composite membrane, which is usually composed of a cation exchange layer (N-type membrane), an interface hydrophilic layer (catalytic layer) and an anion exchange layer (P-type membrane), and is a real reaction membrane. Under the action of the DC electric field, the bipolar membrane can dissociate water, and hydrogen ions and hydroxide ions are obtained on both sides of the membrane. Utilizing this feature, the bipolar membrane electrodialysis device 500, which is composed of a bipolar membrane and other anion and cation exchange membranes, can convert the salt in the aqueous solution into the corresponding acid and alkali without introducing new components. The present application uses a bipolar membrane electrodialysis device 500 to separate and remove part of the sodium ions of the sodium sarcosinate aqueous solution to obtain a sodium sarcosinate aqueous solution and a sodium hydroxide aqueous solution with a pH of 9 to 10. The sodium sarcosinate aqueous solution with a pH of 9 to 10 is transported to the creatine monohydrate reactor 300 through the first product discharge pipe 520 for reaction. The sodium hydroxide aqueous solution passes through the sodium hydroxide recovery pipe 510. In order to recycle this part of the sodium hydroxide, the outlet of the sodium sarcosinate reactor 400 is connected to the inlet of the bipolar membrane electrodialysis device 500, and the sodium hydroxide aqueous solution is transported to the sodium sarcosinate reactor 400 for continued reaction to achieve recycling.

[0030] Further, in the above-mentioned creatine monohydrate production system, a second polymer filtration membrane device 600 is also included, the first product discharge pipe 520 is connected to the inlet of the second polymer filtration membrane device 600, the second polymer filtration membrane device 600 is provided with a first by-product discharge pipe, a second product discharge pipe 620, and the second product discharge pipe 620 is connected to the inlet of the creatine monohydrate reactor 300. The sodium sarcosinate aqueous solution separated by the bipolar membrane electrodialysis device 500 contains incompletely reacted methylaminoacetonitrile, and the sodium sarcosinate aqueous solution is transported to the second polymer filtration membrane device 600 through the first product discharge pipe 520. After filtering in the second polymer filtration membrane device 600, by-products such as organic matter are discharged through the first by-product discharge pipe, and the discharged by-products can be used for the production of other chemical products, and can also be used to manufacture organic nitrogen fertilizers. In this scheme, it is preferably used to manufacture organic nitrogen fertilizers. The filtered sodium sarcosinate aqueous solution is transported to the creatine monohydrate reactor 300 through the second product discharge pipe 620 for reaction. The second polymer filtration membrane device 600 may be a reverse osmosis membrane, an ultrafiltration membrane, a microporous filtration membrane, a nanofiltration membrane, a microfiltration membrane, etc. In this solution, an ultrafiltration membrane may be preferably used.

[0031] In the present application, the polymer filtration membranes used in the first polymer filtration membrane device 200 and the second polymer filtration membrane device 600 can be regenerated cellulose polymer membranes, polyamide polymer membranes, polysulfone\polyethersulfone polymer membranes, polyvinylidene fluoride polymer membranes, polytetrafluoroethylene polymer membranes, polypropylene polymer membranes, etc., and the present application does not limit this.

[0032] As mentioned above, the discharged byproducts can be used to manufacture organic nitrogen fertilizers, so the above-mentioned creatine monohydrate production system also includes a fertilizer production system 700, and the first polymer filtration membrane device 200 is also provided with a second byproduct discharge pipe 220, and the first byproduct discharge pipe 220 and the second byproduct discharge pipe 220 are both connected to the fertilizer production system 700. The byproducts filtered by the first polymer filtration membrane device 200 and the second polymer filtration membrane device 600 can be transported to the fertilizer production system 700 to produce organic nitrogen fertilizers.

[0033] In another specific embodiment of the present application, the creatine monohydrate separation device 100 includes a crystallization reactor 120 and a centrifuge 130, the outlet of the creatine monohydrate reactor 300 is connected to the inlet of the crystallization reactor 120, the outlet of the crystallization reactor 120 is connected to the inlet of the centrifuge 130, the solid phase outlet of the centrifuge 130 is the creatine monohydrate finished product outlet, and the liquid phase outlet of the centrifuge 130 is connected to the mother liquor discharge pipe 110.

[0034] The creatine monohydrate solution generated by the reaction in the creatine monohydrate reactor 300 is transported to the crystallization reactor 120, where it is cooled and crystallized to precipitate creatine monohydrate crystals, and then passed through the centrifuge 130 to separate the creatine monohydrate crystals and the mother liquor, wherein the creatine monohydrate crystals are discharged from the solid phase outlet of the centrifuge 130, and the mother liquor is transported from the liquid phase outlet of the centrifuge 130 through the mother liquor discharge pipe 110 to the first polymer filtration membrane device 200.

[0035] Preferably, a pH sensor 410 is further provided at the inlet of the sodium sarcosinate reactor 400, and an electric valve 511 is further provided on the sodium hydroxide recovery pipe 510, and the pH sensor 410 and the electric valve 511 are electrically connected. Since the sodium hydroxide in the sodium hydroxide recovery pipe 510 is produced by the bipolar membrane electrodialysis device 500 after the reaction, its addition may affect the pH value of the total sodium hydroxide entering the sodium sarcosinate reactor 400. Therefore, in order to meet the required pH value in the sodium sarcosinate reactor 400 (that is, to control the amount of sodium hydroxide), a pH sensor 410 is provided at the inlet of the sodium sarcosinate reactor 400, and an electric valve 511 is provided on the sodium hydroxide recovery pipe 510. The real-time pH value detected by the pH sensor 410 is fed back to the control system, and the control system adjusts the opening of the electric valve 511 according to production needs, thereby achieving the purpose of adjusting the pH value of the inlet of the sodium sarcosinate reactor 400.

[0036] The specific working process is as follows: the methylaminoacetonitrile aqueous solution and the sodium hydroxide aqueous solution react in the sodium sarcosinate reactor 400 to generate the sodium sarcosinate aqueous solution. The generated sodium sarcosinate aqueous solution is transported to the bipolar membrane electrodialysis device 500 to adjust its pH to 9 to 10. The sodium hydroxide aqueous solution generated in this process is transported to the inlet of the sodium sarcosinate reactor 400 through the sodium hydroxide recovery pipe 510 to react again. The sodium sarcosinate aqueous solution discharged from the bipolar membrane electrodialysis device 500 is transported to the second polymer filtration membrane device 600 through the first product discharge pipe 520. After being filtered in the second polymer filtration membrane device 600, by-products such as organic matter are transported to the fertilizer production system 700 through the first by-product discharge pipe to manufacture organic nitrogen fertilizer. The filtered sodium sarcosinate aqueous solution is transported to the creatine monohydrate reactor 300 through the second product discharge pipe 620, and cyanamide is added to the creatine monohydrate reactor 300 to generate a creatine monohydrate solution. The creatine monohydrate solution is transported from the outlet of the creatine monohydrate reactor 300 to the crystallization reactor 120, where it is cooled and crystallized to precipitate creatine monohydrate crystals, and then the creatine monohydrate crystals and the mother liquor are separated by the centrifuge 130, wherein the creatine monohydrate crystals are discharged from the solid phase outlet of the centrifuge 130, and the mother liquor is transported from the liquid phase outlet of the centrifuge 130 through the mother liquor discharge pipe 110 to the first polymer filtration membrane device 200. After filtration in the first polymer filtration membrane device 200, the byproducts are transported to the fertilizer production system 700 through the second byproduct discharge pipe 220 to manufacture organic nitrogen fertilizer. The filtrate is transported to the creatine monohydrate reactor 300 through the circulating material discharge pipe 210 for repeated use and participating in the reaction again, which can improve the utilization rate of methylaminoacetonitrile and sodium sarcosinate and part of creatine monohydrate in the filtrate, thereby saving raw materials.

[0037] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the embodiments here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A creatine monohydrate production system, characterized in that: include: A creatine monohydrate separation device, wherein the creatine monohydrate separation device is provided with a mother liquor discharge pipe; The first polymer filtration membrane device, the mother liquid discharge pipe is connected to the inlet of the first polymer filtration membrane device, and the first polymer filtration membrane device is provided with a circulating material discharge pipe.

2. The creatine monohydrate production system according to claim 1, characterized in that: It also includes a creatine monohydrate reactor, the outlet of which is connected to the inlet of the creatine monohydrate separation device, and the circulating material discharge pipe is connected to the inlet of the creatine monohydrate reactor.

3. The creatine monohydrate production system according to claim 2, characterized in that: The invention also comprises a sodium sarcosinate reactor, wherein the outlet of the sodium sarcosinate reactor is connected to the inlet of the creatine monohydrate reactor.

4. The creatine monohydrate production system according to claim 3, characterized in that: It also includes a bipolar membrane electrodialysis device, the outlet of the sodium sarcosinate reactor is connected to the inlet of the bipolar membrane electrodialysis device, the bipolar membrane electrodialysis device is provided with a sodium hydroxide recovery pipe and a first product discharge pipe, the sodium hydroxide recovery pipe is connected to the inlet of the sodium sarcosinate reactor, and the first product discharge pipe is connected to the inlet of the creatine monohydrate reactor.

5. The creatine monohydrate production system according to claim 4, characterized in that: It also includes a second polymer filtration membrane device, the first product discharge pipe is connected to the inlet of the second polymer filtration membrane device, the second polymer filtration membrane device is provided with a first by-product discharge pipe and a second product discharge pipe, and the second product discharge pipe is connected to the inlet of the creatine monohydrate reactor.

6. The creatine monohydrate production system according to claim 5, characterized in that: It also includes a fertilizer production system, and the first by-product discharge pipe is connected to the fertilizer production system.

7. The creatine monohydrate production system according to claim 6, characterized in that: The first polymer filtration membrane device is also provided with a second by-product discharge pipe, and the second by-product discharge pipe is connected to the fertilizer production system.

8. The creatine monohydrate production system according to claim 2, characterized in that: The creatine monohydrate separation device comprises a crystallization reactor and a centrifuge, wherein the outlet of the creatine monohydrate reactor is connected to the inlet of the crystallization reactor, the outlet of the crystallization reactor is connected to the inlet of the centrifuge, the solid phase outlet of the centrifuge is the outlet of the creatine monohydrate finished product, and the liquid phase outlet of the centrifuge is connected to the mother liquor discharge pipe.

9. The creatine monohydrate production system according to claim 4, characterized in that: The inlet of the sodium sarcosine reactor is also provided with a pH sensor, and the sodium hydroxide recovery pipe is also provided with an electric valve, and the pH sensor is electrically connected to the electric valve.

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