Constant temperature device for stem cells

Abstract

The utility model discloses a constant temperature device for stem cells, which comprises a box body and a cover body covered on the box body, a test tube positioning plate is horizontally arranged in the box body, a plurality of test tubes filled with stem cell solution are arranged on the test tube positioning plate, a plurality of taking and placing holes are arranged on the cover body, cocks are arranged on the taking and placing holes, and the stem cell solution is placed in the test tube positioning plate. The positions of the pick-and-place holes correspond to the test tubes in the box body one by one up and down, the side walls of the box body and the cover body are vacuumized, and heat preservation layers are arranged on the inner sides and the outer sides of the box body and the cover body. When stem cell test tubes are taken and placed, heat exchange between the interior of the box body and the external environment can be reduced, it is effectively guaranteed that the temperature in the box body is constant, the test tubes can be fixed in the box body more firmly, and shaking is avoided in the transferring process.

Description

Technical Field

[0001] The utility model relates to a constant temperature device for stem cells, belonging to the technical field of constant temperature preservation of stem cells. Background Art

[0002] Stem cells are a type of multipotent cells with the ability to self-replicate. Under certain conditions, they can differentiate into multiple functional cells. Stem cells are not fully differentiated and immature cells that have the potential to regenerate various tissues, organs and the human body. They can treat a variety of genetic diseases and cancers or be used for organ transplantation, etc. The medical community calls them "universal cells." In order to avoid contamination caused by long-term in vitro culture of cultured cells or gene mutations caused by multiple passages, the experimenters will freeze the cultured cells during the vigorous growth period. The frozen cells are stored in cell cryopreservation tubes with cell freezing solution added, and then placed in liquid nitrogen at -156~-196℃. In this ultra-low temperature environment, the cells can be stored for a long time, maximizing the genetic stability of the cells.

[0003] The Chinese utility model patent with authorization announcement number CN218345423U discloses an insulated box for stem cell culture. The stem cell culture bottle can be stably fixed by a fixator to prevent collision or damage. The hollow interior can be used to add ice packs to provide an effective low-temperature environment. The baffles and blocks of the cover and box body can make the insulated box better closed and increase its airtightness.

[0004] However, the above patent has the following problems in practical application:

[0005] First, when the lid is opened to take out and put in stem cells, heat exchange occurs between the inside of the box and the outside, and the temperature inside the box cannot be kept constant;

[0006] Second, by placing ice packs in the box to increase stability, the ice cubes are irregular in shape and not firmly fixed.

[0007] In summary, the prior art obviously has inconveniences and defects in practical use, so it is necessary to improve it. Utility Model Content

[0008] In view of the deficiencies in the background technology, the utility model provides a constant temperature device for stem cells, which can reduce the heat exchange between the inside of the box and the external environment when taking and placing stem cell test tubes, effectively ensure the constant temperature inside the box, and can fix the test tubes more firmly inside the box to avoid shaking during transportation.

[0009] In order to solve the above technical problems, the utility model adopts the following technical solutions:

[0010] A constant temperature device for stem cells comprises a box body and a cover body covering the box body, wherein a test tube positioning plate is horizontally placed in the box body, and a plurality of test tubes containing stem cell solutions are placed on the test tube positioning plate, and a plurality of taking and placing holes are arranged on the cover body, and cocks are installed on the taking and placing holes, and the positions of the taking and placing holes are arranged one by one in the upper and lower directions corresponding to the test tubes in the box body.

[0011] Furthermore, the side walls of the box body and the cover body are vacuum-drawn, and the inner and outer sides of the box body and the cover body are provided with insulation layers.

[0012] Furthermore, a partition is provided at the opening at the upper end of the box body, one side of the partition is hinged to the upper end of the box body opening, and a plurality of avoidance holes are provided on the partition board for avoiding the test tubes.

[0013] Furthermore, rib plates are respectively provided on both sides of the interior of the box body, and a placement groove is provided inside the box body, and both sides of the placement groove are placed on the rib plates.

[0014] Furthermore, a limiting protrusion is provided at the middle position of the upper end of each side rib plate, and a positioning groove is provided at both ends of the placement groove respectively, and the positioning groove cooperates with the limiting protrusion.

[0015] Furthermore, there are two test tube positioning plates, and both are placed on the upper surface of the placement slot.

[0016] Furthermore, positioning columns are respectively provided at both ends of the positioning groove, and limiting holes are respectively provided at both ends of the test tube positioning plate, and the limiting holes cooperate with the positioning columns.

[0017] Furthermore, support columns are provided at both ends of the test tube positioning plate, and after the partition is buckled, the support columns are pressed against the lower surface of the partition.

[0018] Furthermore, an ultraviolet lamp is installed inside the box.

[0019] Furthermore, a position sensor is provided near each test tube in the box, and a display is provided on the outside of the box. The display indicates whether there is a test tube at each position according to the signal of the position sensor.

[0020] Compared with the prior art, the utility model has the following advantages after adopting the above technical solution:

[0021] 1. The cover is provided with a plurality of access holes, on which cocks are installed, and the positions of the access holes correspond to the test tubes in the box. When a single test tube needs to be accessed, the corresponding cock is opened, and the corresponding test tube is taken out through the test tube clamping device without opening the cover, thereby reducing the heat exchange between the inside of the box and the external environment, and effectively ensuring the constant temperature in the box.

[0022] 2. A partition is also provided at the opening at the upper end of the box body, which plays a role of heat insulation. After the partition is buckled, the support column is pressed against the lower surface of the partition. The support column presses against the partition to prevent the test tube positioning plate from moving up and down.

[0023] 3. A position sensor is provided near each test tube in the box, and a display is provided on the outside of the box. The display indicates whether there is a test tube at each position according to the signal of the position sensor, so that the presence or absence of the test tube in the box can be known without opening the cover, thereby reducing the heat exchange between the inside of the box and the external environment.

[0024] The utility model is described in detail below with reference to the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the structure of the cover body buckled;

[0026] Figure 2 It is a schematic diagram of the structure with the cover and the partition opened;

[0027] Figure 3 It is a schematic diagram of the structure with the cover body opened and the partition closed;

[0028] Figure 4 It is a schematic diagram of the structure of the placement slot;

[0029] Figure 5 It is a structural schematic diagram of a test tube positioning plate.

[0030] In the figure,

[0031] 1-cover body, 101-removal hole, 2-box body, 201-rib plate, 202-limiting protrusion, 3-cock, 4-switch lock, 5-display, 6-ultraviolet lamp, 7-partition, 701-avoidance hole, 8-placing slot, 801-positioning column, 802-positioning slot, 9-test tube positioning plate, 901-limiting hole, 902-support column, 10-test tube, 11-position sensor. DETAILED DESCRIPTION

[0032] In order to have a clearer understanding of the technical features, purposes and effects of the utility model, the specific implementation methods of the utility model are now described with reference to the accompanying drawings.

[0033] like Figure 1As shown, the utility model provides a constant temperature device for stem cells, including a box body 2 and a cover body 1 covering the box body 2, both of which are opened or closed by a switch lock 4, the inside of the box body 2 is filled with liquid nitrogen, a test tube positioning plate 9 is horizontally placed in the box body 2, and a plurality of test tubes 10 containing stem cell solutions are placed on the test tube positioning plate 9, and a plurality of access holes 101 are provided on the cover body 1, and a cock 3 is installed on the access holes 101, and the positions of the access holes 101 are arranged one by one in upper and lower correspondence with the test tubes 10 in the box body 2. When a single test tube 10 needs to be accessed, the corresponding cock 3 is opened, and the corresponding test tube 10 is taken out by the test tube clamping device without opening the cover body 1, thereby reducing the heat exchange between the inside of the box body and the external environment, and effectively ensuring the constant temperature in the box body.

[0034] The side walls of the box body 2 and the cover body 1 are vacuum-drawn, and the inner and outer sides of the box body 2 and the cover body 1 are provided with a heat-insulating layer.

[0035] A partition 7 is provided at the opening of the upper end of the box body 2 , one side of the partition 7 is hinged to the upper end of the opening of the box body 2 , and a plurality of avoidance holes 701 are provided on the partition 7 for avoiding the test tubes 10 .

[0036] Rib plates 201 are provided on both sides of the box body 2, and a placement groove 8 is provided inside the box body 2. Both sides of the placement groove 8 are placed on the rib plates 201. Figure 5 The test tube positioning plate 9 and the test tube 10 are placed in the placement groove 8, and the liquid nitrogen is between the placement groove 8 and the inner wall of the box body 2.

[0037] A limiting protrusion 202 is provided in the middle position of the upper end of each side rib plate 201 , and a positioning groove 802 is provided at both ends of the placement groove 8 , respectively. The positioning groove 802 cooperates with the limiting protrusion 202 to prevent the positioning groove 802 from moving.

[0038] There are two test tube positioning plates 9 , and both are placed on the upper surface of the placement slot 8 .

[0039] Positioning posts 801 are respectively disposed at both ends of the positioning groove 802 , and limiting holes 901 are respectively disposed at both ends of the test tube positioning plate 9 . The limiting holes 901 cooperate with the positioning posts 801 to prevent the test tube positioning plate 9 from moving.

[0040] The two ends of the test tube positioning plate 9 are also provided with support columns 902, and after the partition 7 is buckled, the support columns 902 are pressed against the lower surface of the partition 7. The support columns 902 press against the partition 7 to prevent the test tube positioning plate 9 from moving up and down, and when taking and placing the test tube positioning plate 9, it is convenient to take and place by grasping the support columns 902.

[0041] An ultraviolet lamp 6 is installed inside the box body 2 to sterilize the box body 2.

[0042] A position sensor 11 is provided near each test tube 10 in the box 2, and a display 5 is provided on the outside of the box 2. The display 5 indicates whether there is a test tube 10 at each position according to the signal of the position sensor 11, so that the presence or absence of the test tube 10 in the box 2 can be known without opening the cover 1.

[0043] The specific working principle of the utility model:

[0044] The utility model includes a box body 2 and a cover body 1. A placement slot 8 is provided inside the box body 2. A test tube positioning plate 9 and a test tube 10 are placed in the placement slot 8. Liquid nitrogen is between the placement slot 8 and the inner wall of the box body 2. A plurality of access holes 101 are provided on the cover body 1. A cock 3 is installed on the access holes 101. The positions of the access holes 101 correspond to the test tubes 10 in the box body 2. When a single test tube 10 needs to be accessed, the corresponding cock 3 is opened, and the corresponding test tube 10 is taken out by the test tube clamping device without opening the cover body 1, thereby reducing the heat exchange between the inside of the box and the external environment, and effectively ensuring the constant temperature in the box.

[0045] The opening at the upper end of the box body 2 is also provided with a partition 7, which plays a heat insulation role. After the partition 7 is buckled, the support column 902 is pressed against the lower surface of the partition 7. The support column 902 presses against the partition 7 to prevent the test tube positioning plate 9 from moving up and down.

[0046] A position sensor 11 is provided near each test tube 10 in the box 2, and a display 5 is provided on the outside of the box 2. The display 5 indicates whether there is a test tube 10 at each position according to the signal of the position sensor 11, so that the presence or absence of the test tube 10 in the box 2 can be known without opening the cover 1, thereby reducing the heat exchange between the inside of the box and the external environment.

[0047] The above is an example of the best implementation of the utility model, and the parts not described in detail are common knowledge of ordinary technicians in this field. The protection scope of the utility model is based on the content of the claims, and any equivalent transformation based on the technical inspiration of the utility model is also within the protection scope of the utility model.

Claims

1. A constant temperature device for stem cells, comprising a box (2) and a cover (1) covering the box (2), wherein a test tube positioning plate (9) is horizontally placed in the box (2), and a plurality of test tubes (10) containing stem cell solutions are placed on the test tube positioning plate (9), characterized in that: The cover body (1) is provided with a plurality of access holes (101), each of which is provided with a cock (3), and the positions of the access holes (101) are arranged in a one-to-one vertical correspondence with the test tubes (10) in the box body (2).

2. A constant temperature device for stem cells as claimed in claim 1, characterized in that: The side walls of the box body (2) and the cover body (1) are vacuum-drawn, and the inner and outer sides of the box body (2) and the cover body (1) are both provided with thermal insulation layers.

3. A constant temperature device for stem cells as claimed in claim 1, characterized in that: A partition (7) is provided at the opening at the upper end of the box body (2), one side of the partition (7) is hinged to the upper end of the opening of the box body (2), and a plurality of avoidance holes (701) are provided on the partition (7) for avoiding the test tubes (10).

4. A constant temperature device for stem cells as claimed in claim 1, characterized in that: Rib plates (201) are respectively provided on both sides of the interior of the box body (2), and a placement groove (8) is provided inside the box body (2), with both sides of the placement groove (8) resting on the rib plates (201).

5. A constant temperature device for stem cells as claimed in claim 4, characterized in that: A limiting protrusion (202) is provided at the middle position of the upper end of each side rib plate (201), and a positioning groove (802) is provided at each end of the placement groove (8), and the positioning groove (802) and the limiting protrusion (202) cooperate with each other.

6. A constant temperature device for stem cells as claimed in claim 5, characterized in that: There are two test tube positioning plates (9), and both are placed on the upper surface of the placement groove (8).

7. A constant temperature device for stem cells as claimed in claim 6, characterized in that: The two ends of the positioning groove (802) are respectively provided with positioning posts (801), and the two ends of the test tube positioning plate (9) are respectively provided with limiting holes (901), and the limiting holes (901) are matched with the positioning posts (801).

8. A constant temperature device for stem cells as claimed in claim 3, characterized in that: Support columns (902) are also provided at both ends of the test tube positioning plate (9). After the partition (7) is fastened, the support columns (902) are pressed against the lower surface of the partition (7).

9. The constant temperature device for stem cells according to claim 1, characterized in that: An ultraviolet lamp (6) is installed inside the box (2).

10. The constant temperature device for stem cells according to claim 1, characterized in that: A position sensor (11) is provided near each test tube (10) in the box (2), and a display (5) is provided outside the box (2). The display (5) indicates whether a test tube (10) is present at each position according to a signal from the position sensor (11).

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