Quick split charging device for freeze-dried microspheres

Abstract

The utility model discloses a quick split charging device for freeze-dried microspheres. The scheme comprises a sub-packaging assembly and a cover body at the top; the sub-packaging assembly comprises a screening part with a through hole, a limiting plate and a sub-packaging part, and the screening part is divided into a screening cavity and a storage cavity by a baffle. The split charging assembly provided by the scheme is simple in structure, easy to operate and convenient to use; according to the screening part provided by the scheme, by adding the storage cavity, the trouble that redundant freeze-dried microspheres need to be poured out after the freeze-dried microspheres fall into the screening holes every time is avoided, the freeze-dried microspheres do not need to be added into the screening tray before subpackaging every time, time and labor are saved, and operation is convenient; according to the scheme, the cover body is transparent and visual, the internal working state can be observed conveniently, meanwhile, the shielding effect can be achieved, and freeze-dried microspheres are prevented from being shaken out of the screening part in the screening process.

Description

Technical Field

[0001] The present invention relates to the technical field of biological reagent production, and in particular to a freeze-dried microsphere rapid dispensing device. Background Art

[0002] In recent years, with the rapid development of microfluidics technology, freeze-dried microspheres have been widely used in many fields such as biomedical research, clinical diagnosis, drug development, food hygiene and environmental monitoring. As biological reagents, freeze-dried microspheres have a longer shelf life than liquid reagents, and are more convenient to transport and use. However, freeze-dried microspheres are very fragile and cannot withstand large external forces. It is extremely difficult to separate individual freeze-dried microspheres during the packaging process. In particular, immune reagents containing proteins, enzymes and other ingredients are very sensitive to temperature. The freeze-dried microspheres made of immune reagents require moisture to be controlled at about 1% and the packaging environment humidity to be about 5%, otherwise they will absorb moisture and become ineffective. The lower the humidity, the more likely the freeze-dried microspheres will generate static electricity, making it difficult to carry out batch production of microspheres and packaging.

[0003] At present, the industry basically relies on manual separation of freeze-dried reagent microspheres using tweezers in a controlled humidity environment. The freeze-dried microspheres are manually placed one by one into a specific reagent reaction cup. The separation efficiency is extremely low, which can easily cause reagent contamination and inaccurate testing. Operators cannot work in a low-humidity environment for a long time, which can easily cause physical discomfort, and it cannot meet the needs of mass production.

[0004] The Chinese patent application publication number is CN218198892U, and the publication date is January 3, 2023. The invention name is a utility model patent for a freeze-dried microsphere dispensing device, including a dispensing base, a container carrier, and a dispensing tray; the container carrier is slidably connected to the dispensing base, and a plurality of receiving holes are evenly distributed on the container carrier;

[0005] The filling tray is mounted on the filling base and is located above the container carrier; the filling tray includes a filling main board, a sieve plate, two baffles and two handles; the baffles are symmetrically and detachably arranged on the filling main board, and the handles are fixedly arranged on the filling main board, and a storage space for placing freeze-dried microspheres is formed between the filling main board, the baffles and the handles; the deficiency of the above-mentioned public document is that in the process of implementing the scheme, freeze-dried microspheres are added to the sieve plate. Each time the freeze-dried microspheres are shaken to fall into the sieve holes, it is necessary to open the baffle to pour out the excess freeze-dried microspheres, and then the filling tray is installed on the filling base. After the sieve holes are connected with the filling through holes, the freeze-dried microspheres fall into the filling container of the container carrier through the filling through holes under the action of their own weight. When the next step is carried out, it is necessary to add freeze-dried microspheres to the sieve plate again. Of course, the fixed amount of freeze-dried microspheres can be increased each time the freeze-dried microspheres are added, which can avoid the process of removing the baffle, but the number of freeze-dried microspheres still needs to be counted, and new freeze-dried microspheres still need to be added each time they are packaged. In summary, the packaging device in the prior art has a complex structure, cumbersome operating steps, and is time-consuming and labor-intensive to use.

[0006] Therefore, a packaging device is needed to quickly package the freeze-dried microspheres. Summary of the invention

[0007] In order to solve the above problems, the present invention provides a freeze-dried microsphere rapid packaging device, which has a simple structure and can quickly package the freeze-dried microspheres.

[0008] To achieve the above-mentioned purpose, the technical solution adopted in this scheme is: a freeze-dried microsphere rapid packaging device, including a packaging component and a top cover; the packaging component includes a sieve part with a through hole, a limit plate and a packaging part, and the sieve part is divided into a sieve chamber and a storage chamber by a baffle.

[0009] Furthermore, first through holes are evenly distributed on the bottom of the sub-sieve cavity, the first through holes have a diameter of D and a depth of H1, and the diameter of the freeze-dried microspheres is d, wherein d<D<2d, 1 / 2d<H<d.

[0010] Furthermore, one end of the baffle is fixed to the inner wall of the sub-screening portion, and a flow opening is formed between the other end and the inner wall of the sub-screening portion.

[0011] Furthermore, the baffle comprises a slide plate slidably connected in the sliding groove, and the slide plate forms a flow opening when it is retracted.

[0012] Furthermore, in the subpackaging part, connecting female ends are arranged around the top of the base, and a plate groove with a notch is formed in the middle, and the limiting plate can move back and forth in the plate groove.

[0013] Furthermore, third through holes connected to the discharge pipe are evenly distributed in the plate groove 134 .

[0014] Furthermore, the limiting plate has one side of the plate body connected to the pressing end and the other side connected to the elastic member, and the second through holes are evenly distributed on the plate surface.

[0015] Furthermore, the elastic member is a spring structure, which is limited on a limiting rod on the inner wall of the plate groove.

[0016] Furthermore, the connecting sub-end at the bottom surface of the sub-screening portion corresponds to the connecting female end at the top of the sub-packaging portion.

[0017] Furthermore, the connecting sub-end is a connecting rod, and the connecting female end is a connecting groove.

[0018] In summary, this solution has the following advantages:

[0019] 1. The subassembly components provided in this solution have simple structure, are easy to operate and convenient to use;

[0020] 2. The sieving part provided in this scheme avoids the tediousness of pouring out the excess lyophilized microspheres after each lyophilized microsphere falls into the sieving hole by adding a storage cavity, and there is no need to add lyophilized microspheres to the sieving plate before each subpackaging, which saves time and effort and is easy to operate;

[0021] 3. The cover provided by this solution is transparent and visualized, which is convenient for observing the internal working status. At the same time, it can play a shielding role to prevent the freeze-dried microspheres from being shaken out of the screening part during the screening process;

[0022] 4. The slide plate provided in this solution prevents the freeze-dried microspheres from mistakenly entering the sieving chamber from the storage chamber due to excessive force during the shaking of the sieving section. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram of a freeze-dried microsphere rapid dispensing device;

[0024] Figure 2 This is an exploded view of the freeze-dried microsphere rapid dispensing device;

[0025] Figure 3 is a schematic diagram of the bottom of the screening section;

[0026] Figure 4 is a schematic diagram of a limit plate;

[0027] Figure 5 It is a schematic diagram of the sub-packaging section;

[0028] Figure 6 is a cross-sectional view of the sub-packaging portion;

[0029] Figure 7 Schematic diagram of another embodiment of the screening unit.

[0030] in:

[0031] 100. Packaging components;

[0032] 110, sub-screening part; 111, baffle; 1111, flow port; 1112, slide plate; 1113, sliding groove; 112, sub-screening cavity; 1121, first through hole; 113, storage cavity; 114, connecting sub-end;

[0033] 120, limit plate; 121, plate body; 1211, second through hole; 122, pressing end; 123, elastic member;

[0034] 130, subpackaging part; 131, base; 1311, third through hole; 1312, discharge pipe; 132, convex part; 133, connecting female end; 134, plate groove; 1341, limit rod;

[0035] 200. Cover body. DETAILED DESCRIPTION

[0036] The present invention is further described below in conjunction with the accompanying drawings and embodiments:

[0037] Embodiment 1:

[0038] A freeze-dried microsphere rapid dispensing device, referring to the figure, comprises a dispensing component 100 and a cover body 200 at the top.

[0039] The sub-packaging assembly 100 includes, from top to bottom, a sub-screening portion 110 , a limiting plate 120 , and a sub-packaging portion 130 .

[0040] The subassembly assembly 100 provided in this solution has a simple structure, is easy to operate, and is convenient to use.

[0041] The sub-screening part 110 is a box structure, and the internal baffle 111 divides the sub-screening part 110 into a sub-screening chamber 112 and a storage chamber 113 . The sub-screening chamber 112 and the storage chamber 113 are in communication.

[0042] The first through holes 1121 are evenly distributed at the bottom of the sub-screening cavity 112. The diameter of the first through holes 1121 is D and the depth is H1. The diameter of the freeze-dried microspheres is d, wherein d<D<2d, 1 / 2d<H<d. The diameters of the second through holes 1211 on the limiting plate 120 and the third through holes 1311 of the sub-packaging part 130 are both D.

[0043] One end of the baffle 111 is fixed to the inner wall of the sub-screening portion 110 , and a gap exists between the other end of the baffle 111 and the inner wall of the sub-screening portion 110 , forming a flow opening 1111 .

[0044] The bottom of the storage cavity protrudes outward, and the concave part in the cavity is used to store the excess freeze-dried microspheres after sieving.

[0045] In the structural setting of this solution, the screening part 110 can overcome the problems of complicated operation steps, time-consuming and labor-intensive in the prior art. By adding a storage cavity, it is avoided that after each freeze-dried microsphere falls into the screening hole, the tediousness of pouring out the excess freeze-dried microspheres is avoided, and there is no need to add freeze-dried microspheres to the screening plate before each subpackaging, which saves time and labor and is easy to operate.

[0046] The top of the sub-screening part 110 includes a cover 200 .

[0047] In the structural setting of the present solution, the cover body 200 is a transparent visual structure. In this embodiment, the cover body 200 directly covers the top of the screening part 110 .

[0048] The cover 200 provided in the present solution is transparent and visual, which facilitates observation of the internal working status. At the same time, it can play a shielding role to prevent the freeze-dried microspheres from being shaken out of the screening part 110 during the screening process.

[0049] The material of the cover 200 is preferably PP (polypropylene), which has high transparency and good heat resistance, can resist corrosion from a variety of chemical solvents, and is suitable for different sealing methods. In addition, PP material also has the characteristics of light weight, low cost, and little impact on the environment.

[0050] Of course, the cover 200 may also be made of other transparent and visible materials such as glass, PE (polyethylene), PET (polyethylene terephthalate), etc.

[0051] Specifically, add freeze-dried microspheres to the screening part 110, cover the cover 200, gently shake the freeze-dried microspheres in the screening chamber 112, observe inward through the cover 200, ensure that the first through hole 1121 at the bottom of the screening chamber 112 is filled with freeze-dried microspheres, tilt the dispensing assembly 100, and roll the excess freeze-dried microspheres into the storage chamber through the flow port 1111. When performing the next screening, directly flip the dispensing assembly 100, and the freeze-dried microspheres roll from the storage chamber through the flow port 1111 into the screening chamber 112, and repeat the above screening action.

[0052] The connecting sub-ends 114 are evenly distributed on the bottom surface of the sub-screening portion 110 , and the connecting sub-ends 114 correspond to the connecting female ends 133 at the top edge of the sub-packaging portion 130 .

[0053] The subpackaging portion 130 and the top edge of the base 131 include a protrusion 132 with a connecting female end 133, and a notch is provided on the protrusion 132 on one short side. The protrusion 132 forms a plate groove 134 on the top of the base 131, and the third through holes 1311 are evenly distributed in the plate groove 134. The limiting plate 120 can move back and forth in the plate groove 134.

[0054] In this solution, the connecting sub-end 114 and the connecting female end 133 serve as the connecting structure between the sub-screening part 110 and the sub-packaging part 130, and mainly play the role of fixing the position to ensure that after the sub-screening part 110 and the sub-packaging part 130 are assembled, the first through hole 1121 and the third through hole 1311 correspond to each other in the vertical direction.

[0055] In this embodiment, the connecting sub-end 114 is a connecting rod, and the connecting female end 133 is a connecting groove.

[0056] Specifically, after installation, the connecting sub-end 114 and the connecting female end 133 are fixed, the inner side of the storage cavity protruding from the bottom of the sub-screening portion 110 fits against the side of the sub-packaging portion 130 , and the top of the sub-packaging portion 130 fits against the edge of the sub-screening cavity 112 at the bottom of the sub-screening portion 110 .

[0057] The limiting plate 120 has a plate body 121 with one side connected to a pressing end 122 and the other side connected to an elastic member 123. The elastic member 123 is limited on a limiting rod 1341 on the inner wall of the plate groove 134. The second through holes 1211 are evenly distributed on the plate surface.

[0058] In the structural setting of this solution, the plate body 121 with the second through hole 1211 is pushed inward by pressing the pressing end 122. During the movement of the plate body 121, the second through hole 1211 corresponds to the first through hole 1121 and the third through hole 1311 in a vertical direction, and the freeze-dried microspheres fall from the first through hole 1121 by inertia, and fall into the third through hole 1311 through the second through hole 1211. The elastic member 123 is used to reset the limit plate 120. In this embodiment, the elastic member 123 is symmetrically arranged on both sides of the plate body 121 and is a spring structure.

[0059] Specifically, the first through hole 1121 and the third through hole 1311 correspond to each other in the vertical direction, one side and the upper and lower ends of the plate body 121 connected to the pressing end 122 are attached to the inner wall of the plate groove 134, the pressing end 122 extends through the gap, the elastic member 123 is in a relaxed state, and the upper and lower openings of the second through hole 1211 are staggered with the first through hole 1121 and the third through hole 1311, and are in a sealed state.

[0060] The pressing end 122 is pressed inward, the elastic member 123 is in a tight state, and the upper and lower openings of the second through hole 1211 correspond to the first through hole 1121 and the third through hole 1311 in a vertical direction, and are in an open state;

[0061] The pressure on the pressing end 122 is released, and the spring relaxes, driving the pressing end 122 to return to its original position.

[0062] The bottom of the third through hole 1311 is connected to a discharge pipe 1312 , and the discharge pipe 1312 is aligned with the reagent reaction cup, and the freeze-dried microspheres fall into the reagent reaction cup through the discharge pipe 1312 .

[0063] Further explanation in combination with its usage mechanism:

[0064] First, add freeze-dried microspheres to the sieving part, cover the cover 200, gently shake the freeze-dried microspheres in the sieving chamber 112, observe inward through the cover 200 to ensure that the first through hole 1121 at the bottom of the sieving chamber 112 is filled with freeze-dried microspheres, tilt the dispensing assembly 100, and roll the excess freeze-dried microspheres into the storage chamber through the flow port 1111. At this time, the bottom of the first through hole 1121 is blocked by the limiting plate 120 and is in a sealed state;

[0065] Then, by pressing the pressing end 122, the limiting plate 120 is pushed inward, the elastic member 123 is in a taut state, the upper and lower openings of the second through hole 1211 correspond vertically to the first through hole 1121 and the third through hole 1311, and are in an open state, and the freeze-dried microspheres fall from the first through hole 1121 by inertia, pass through the second through hole 1211 and fall into the third through hole 1311, and then fall into the reagent reaction cup through the discharge pipe 1312.

[0066] After the freeze-dried microspheres are observed to have completely fallen off through the cover 200, the pressure of the pressing end 122 is released, the spring relaxes, and the limiting plate 120 is driven to reset;

[0067] When performing the next screening, the packaging assembly 100 is directly turned over, and the freeze-dried microspheres roll from the storage chamber through the flow port 1111 into the screening chamber 112, and the above-mentioned screening operation is repeated.

[0068] Embodiment 2:

[0069] The features of this embodiment that are different from those of the first embodiment are as follows:

[0070] In this embodiment, referring to the figure, the baffle 111 inside the sub-screening part includes a slidable slide plate 1112, through which the flow port 1111 between the sub-screening cavity 112 and the storage cavity 113 can be closed or opened. The provision of the slide plate 1112 prevents the freeze-dried microspheres from mistakenly entering the sub-screening cavity 112 from the storage cavity due to excessive force during the shaking of the sub-screening part.

[0071] Specifically, the baffle 111 includes upper and lower corresponding sliding grooves 1113, and the slide plate 1112 is limited in the sliding groove 1113, and the opening and closing is controlled by thrust.

[0072] Further explanation in combination with its usage mechanism:

[0073] Add freeze-dried microspheres to the sieving part, cover the cover 200, gently shake the freeze-dried microspheres in the sieving chamber 112, observe inward through the cover 200, ensure that the first through hole 1121 at the bottom of the sieving chamber 112 is filled with freeze-dried microspheres, tilt the dispensing assembly 100, and roll the excess freeze-dried microspheres into the storage chamber through the flow port 1111. At this time, push the slide plate 1112 to close the flow port 1111;

[0074] When performing the next screening, the slide plate 1112 is pushed to open the flow port 1111 , the dispensing assembly 100 is turned over, and the freeze-dried microspheres roll from the storage chamber through the flow port 1111 into the screening chamber 112 .

[0075] In summary, the subassembly assembly 100 provided in the present application has a simple structure, is easy to operate, and is convenient to use.

[0076] The sieving part 110 provided in the present application avoids the tediousness of pouring out excess freeze-dried microspheres after each freeze-dried microsphere falls into the sieving holes by adding a storage cavity, and also eliminates the need to add freeze-dried microspheres to the sieving plate before each packaging, thereby saving time and effort and facilitating operation.

[0077] The cover 200 provided in the present application is transparent and visual, which facilitates observation of the internal working status. At the same time, it can play a shielding role to prevent the freeze-dried microspheres from being shaken out of the screening part 110 during the screening process.

[0078] The slide plate 1112 provided in the present application prevents the freeze-dried microspheres from mistakenly entering the sieving chamber 112 from the storage chamber due to excessive force during the shaking of the sieving section.

[0079] The above implementation is only to illustrate the technical concept and features of this solution, and its purpose is to enable people familiar with this technology to understand the content of this solution and implement it accordingly, and it cannot be used to limit the protection scope of this solution. Any equivalent transformation or modification made according to the spirit of this solution should be included in the protection scope of this solution.

[0080] In the description of this scheme, it should be noted that, unless otherwise clearly stipulated and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the internal connection of two elements.

[0081] For those skilled in the art, the specific meanings of the above terms in this solution can be understood according to specific circumstances.

[0082] It should be understood that the above-mentioned embodiments are merely illustrative and not restrictive. Without departing from the basic principles of the present solution, various obvious or equivalent modifications or substitutions that can be made by technicians in this field to the above details will be included in the protection scope of the present solution.

Claims

1. A freeze-dried microsphere rapid packaging device, characterized in that: A subassembly assembly (100) and a top cover (200); The sub-packaging assembly (100) comprises a sub-screening portion (110) with a through hole, a limiting plate (120) and a sub-packaging portion (130); the sub-screening portion (110) is divided into a sub-screening chamber (112) and a storage chamber (113) by a baffle (111).

2. The freeze-dried microsphere rapid packaging device according to claim 1, characterized in that: The bottom of the sub-sieve cavity (112) is evenly distributed with first through holes (1121), the first through holes (1121) have a diameter of D and a depth of H1, and the diameter of the freeze-dried microspheres is d, wherein d<D<2d, 1 / 2d<H<d.

3. The freeze-dried microsphere rapid packaging device according to claim 1, characterized in that: One end of the baffle is fixed to the inner wall of the sub-screening portion (110), and a flow opening (1111) is formed between the other end and the inner wall of the sub-screening portion (110).

4. The freeze-dried microsphere rapid packaging device according to claim 1, characterized in that: The baffle (111) comprises a slide plate (1112) slidably connected in a sliding groove (1113), and the slide plate (1112) forms a flow opening (1111) when retracted.

5. The freeze-dried microsphere rapid packaging device according to claim 1, characterized in that: The subpackaging part (130) has connecting female ends (133) arranged around the top of the base (131), and a plate groove (134) with a notch in the middle, and the limiting plate (120) can reciprocate in the plate groove (134).

6. The freeze-dried microsphere rapid packaging device according to claim 5, characterized in that: The plate groove (134) is evenly distributed with third through holes (1311) connected to the discharge pipe (1312).

7. The freeze-dried microsphere rapid packaging device according to claim 5, characterized in that: The limiting plate (120) has a plate body (121) with one side connected to a pressing end (122) and the other side connected to an elastic member (123), and second through holes (1211) are evenly distributed on the plate surface.

8. The freeze-dried microsphere rapid packaging device according to claim 7, characterized in that: The elastic member (123) is a spring structure and is limited on a limiting rod (1341) on the inner wall of the plate groove (134).

9. The freeze-dried microsphere rapid packaging device according to claim 1, characterized in that: The connecting sub-end (114) on the bottom surface of the screening portion (110) corresponds to the connecting female end (133) on the top of the packaging portion (130).

10. The freeze-dried microsphere rapid packaging device according to claim 9, characterized in that: The connecting sub-end (114) is a connecting rod, and the connecting female end (133) is a connecting groove.

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