Blood sample collection card

Abstract

The utility model provides a blood sample collection card, which comprises a first paperboard, an adsorption filter paper and a second paperboard which are sequentially overlapped from top to bottom, the upper surface of the second paperboard is provided with an information collection area and a sample collection area, and the adsorption filter paper is adhered to the sample collection area; a collection hole is formed in the adsorption filter paper, a collection paper sheet is arranged in the collection hole, and the peripheral side of the collection paper sheet is connected with the hole wall of the collection hole through an easily-broken weak part; a first through hole corresponding to the collecting hole is formed in the first paperboard, and the hole wall of the first through hole is located on the peripheral side of the hole wall of the collecting hole. According to the blood sample collection card, sampling is convenient, the collection paper sheet can be taken down only through tweezers to achieve sampling, and tools such as a puncher or scissors are not needed; the first paperboard is stacked on the upper surface of the adsorption filter paper, the situation that a user directly touches the adsorption filter paper by mistake and pollutes the adsorption filter paper during use is prevented, the first paperboard is provided with the first through hole corresponding to the position of the collection paper sheet, and the user can be reminded of the position of the collection paper sheet.

Description

Technical Field

[0001] The utility model relates to a blood sample collection card. Background Art

[0002] Dried Blood Spot (DBS) refers to dropping blood from the fingertips or heels of subjects on relevant sample collection cards, which are naturally dried at room temperature to form blood spots. Its application in the fields of medicine and health sciences simplifies the traditional blood collection and analysis process. In 1911, Ivar Bang, the father of modern clinical microchemistry, introduced a method of absorbing blood onto filter paper to form dried blood spots for the determination of glucose concentration. Guthrie and Susi reported the DBS analysis method for neonatal phenylketonuria in 1963, and the DBS method has since become popular in biological analysis. Venipuncture, as a traditional blood collection technique, may lead to low volunteer recruitment rates in clinical trials due to its invasiveness and traumatic pain. Unlike the shortcomings of venipuncture, DBS blood collection technology is minimally invasive. Blood drops are collected on DBS card paper, and after drying and transportation, dried blood spots are extracted and analyzed in the laboratory. Since the DBS loaded with whole blood has been dried, it is less harmful to organisms. The proteins, pathogens and enzymes contained in the blood are inactivated on the card, and bacterial growth can be effectively prevented. The blood collected and dried on the DBS filter paper can be stored for at least 1 month, and its complement fixation ability has hardly deteriorated. The advantages of dried blood spot technology are low invasiveness and low blood sample requirements, making it a very useful sampling method for subjects. Compared with traditional blood collection technology, dried blood spot technology reduces the steps before sample detection and analysis (such as cold chain transportation, storage and centrifugation process), reduces transportation and storage costs, and improves detection and analysis efficiency.

[0003] Dried blood spot technology has many advantages: (1) less blood is required (the minimally invasive nature is especially important for children, women, the elderly, etc.); (2) the blood collection material supply is simple and low-cost; (3) the risk of sample contamination or hemolysis can be reduced; (4) the sample can be stored for a long time with almost no deterioration; (5) the sampling method is convenient and can be performed independently by medical staff or the subjects in strict accordance with the instructions.

[0004] Although dried blood spots have many advantages, the current sampling operation of dried blood spots is cumbersome. After the blood from the subject's fingertips or heels is dripped onto the relevant sample collection card, a puncher or scissors or other tools are needed to cut the sample collection card to obtain the sample paper. This processing operation is cumbersome and time-consuming. Utility Model Content

[0005] The technical problem to be solved by the utility model is to provide a blood sample collection card to overcome the defect that the prior art needs to use tools such as punchers or scissors to cut the sample collection card to obtain sample paper sheets, and this processing operation is cumbersome and time-consuming.

[0006] The utility model solves the above technical problems through the following technical solutions:

[0007] The utility model provides a blood sample collection card, which comprises a first paperboard, an adsorption filter paper and a second paperboard stacked in sequence, wherein an information collection area and a sample collection area are arranged on the upper surface of the second paperboard, and the adsorption filter paper is adhered to the sample collection area;

[0008] A collection hole is provided on the adsorption filter paper, a collection paper piece is provided in the collection hole, and the outer peripheral side of the collection paper piece is connected to the hole wall of the collection hole through a weak part that is easy to break;

[0009] The first board paper is provided with a first through hole corresponding to the collection hole, and the hole wall of the first through hole is located on the outer peripheral side of the hole wall of the collection hole.

[0010] In this solution, the above-mentioned structural form is adopted. By prefabricating the collection holes on the adsorption filter paper and connecting the collection paper through the easily broken weak part, on the one hand, it is convenient to take samples. The collection paper can be removed by tweezers to achieve sampling. No tools such as punchers or scissors are needed, which reduces the sample loss caused by sample acquisition. On the other hand, the interference of the hematocrit problem can be effectively reduced by the prefabricated collection paper. The prefabricated collection paper can effectively block the diffusion of serum components in the blood during diffusion, and limit the effective solutes within the collection paper. In addition, a first board paper is stacked on the upper surface of the adsorption filter paper to prevent the user from accidentally touching the adsorption filter paper when using the blood sample collection card and causing contamination to the adsorption filter paper. The first board paper is provided with a first through hole corresponding to the position of the collection paper, which can also remind the user of the location of the collection paper, thereby improving the collection efficiency.

[0011] Preferably, there are a plurality of collecting holes, and the plurality of collecting holes are arranged at intervals along the length and / or width direction of the adsorption filter paper.

[0012] In this solution, the above-mentioned structural form is adopted to increase the number of samples by providing multiple collection holes and corresponding collection paper sheets.

[0013] Preferably, the diameter of the collection hole is 0.4 cm-1.6 cm, and the diameter of the first through hole is 0.9 cm-2.1 cm.

[0014] Preferably, the collection paper sheet and the collection hole are circular in shape.

[0015] In this solution, the above-mentioned structural form is adopted, and the circular collection paper piece and the collection hole are easy to manufacture.

[0016] Preferably, there are a plurality of the weak portions, and the plurality of the weak portions are evenly spaced along the circumference of the collection paper sheet.

[0017] In the present solution, the above-mentioned structural form is adopted, and the connection points between the collection paper piece and the weak part are evenly located around the collection paper piece, which makes it easy for tweezers to grab the collection paper piece.

[0018] Preferably, a second through hole corresponding to the collection hole is formed on the second board paper, and a hole wall of the second through hole is located on the outer peripheral side of the hole wall of the collection hole.

[0019] In the present solution, the above-mentioned structural form is adopted. After blood is dripped onto the collection paper from the front side of the second board paper, the penetration of blood on the collection paper can be observed through the second through hole to judge whether the amount of blood collected on the collection paper is appropriate, so as to select a suitable collection paper as a sample for the next step of testing according to the penetration situation.

[0020] Preferably, the blood sample collection card further comprises a covering member, and a locking structure is provided on the second board paper, and the locking structure is configured to fix the covering member so that the covering member covers the sample collection area.

[0021] In this solution, the above-mentioned structural form is adopted. After the blood is collected, the covering member is limited by the cooperation between the covering member and the locking structure, so that the covering member can cover the collection paper to prevent the collection paper from being contaminated.

[0022] Preferably, an end of the cover is connected to an end of the second paperboard close to the sample collection area, and a fold line is provided between the cover and the second paperboard;

[0023] The covering member has a first position and a second position. The covering member is configured to support the second board paper when located at the first position. The locking structure fixes the covering member when the covering member is flipped upward to the second position relative to the second board paper.

[0024] In the present solution, the above-mentioned structural form is adopted, and the covering member is folded along the fold line toward the front or back side of the second paper board. When the covering member is in the first position, the covering member is at a certain angle relative to the second paper board to support the second paper board and prevent the blood sample from overflowing and contacting the tabletop during the sample dripping process; the covering member is flipped upward to cover the collection paper sheet to avoid contamination of the collection paper sheet and facilitate operation.

[0025] Preferably, the locking structure is located between the information collection area and the sample collection area, and a trapezoidal cut is cut on the second board paper as the locking structure, and the trapezoidal cut is used for inserting or removing the cover.

[0026] In this solution, the above-mentioned structural form is adopted, by directly providing a trapezoidal cutout on the second board paper, and inserting the covering member into the trapezoidal cutout to achieve position limiting of the covering member, which is easy to operate.

[0027] Preferably, there are a plurality of locking structures, and the plurality of locking structures are arranged at intervals along the length direction of the adsorption filter paper.

[0028] In this solution, the above-mentioned structural form is adopted, and the cover is limited by multiple locking structures, and the limiting effect is good.

[0029] The positive and progressive effects of the utility model are:

[0030] The blood sample collection card in the utility model prefabricates collection holes on the adsorption filter paper and connects the collection paper piece through a fragile weak part. On the one hand, it is convenient for sampling. The collection paper piece can be removed by tweezers to achieve sampling, and no tools such as punchers or scissors are needed, thereby reducing the sample loss caused by sample acquisition. On the other hand, the interference of the hematocrit problem can be effectively reduced by the prefabricated collection paper piece. The prefabricated collection paper piece can effectively block the diffusion of serum components in the blood during diffusion, and limit the effective solutes within the collection paper piece. In addition, a first board paper is stacked on the upper surface of the adsorption filter paper to prevent the user from accidentally touching the adsorption filter paper directly when using the blood sample collection card and causing contamination to the adsorption filter paper. The first board paper is provided with a first through hole corresponding to the position of the collection paper piece, which can also remind the user of the location of the collection paper piece, thereby improving the collection efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is a schematic diagram of the structure of a blood sample collection card according to a preferred embodiment of the utility model.

[0032] Figure 2 This is a schematic structural diagram of another form of a blood sample collection card according to a preferred embodiment of the utility model.

[0033] Figure 3 This is a schematic structural diagram of a blood sample collection card when the cover of a preferred embodiment of the utility model is in the second position.

[0034] Figure 4 This is a top view of the blood sample collection card when the cover of the preferred embodiment of the utility model is in the first position.

[0035] Figure 5 This is a bottom view of the blood sample collection card when the cover of the preferred embodiment of the utility model is in the first position.

[0036] Figure 6 This is a schematic structural diagram of the second paperboard of a preferred embodiment of the utility model.

[0037] Figure 7 The figure is a schematic structural diagram of the adsorption filter paper according to a preferred embodiment of the utility model.

[0038] Figure 8 The figure is a schematic structural diagram of the first paperboard of a preferred embodiment of the utility model.

[0039] Description of reference numerals:

[0040] First board 1

[0041] The first through hole 11

[0042] Adsorption filter paper 2

[0043] Collection hole 21

[0044] Collecting Paper 22

[0045] Weak Point 23

[0046] Second board 3

[0047] Information collection area 31

[0048] Sample collection area 32

[0049] Second through hole 33

[0050] Lock structure 34

[0051] Trapezoidal cut 341

[0052] Polyline 35

[0053] Cover 4 DETAILED DESCRIPTION

[0054] The present invention will be described more clearly and completely below by way of embodiments in conjunction with the accompanying drawings, but the present invention is not limited to the scope of the following embodiments.

[0055] Please combine Figures 1 to 8For understanding, an embodiment of the utility model provides a blood sample collection card, which includes a first paperboard 1, an adsorption filter paper 2 and a second paperboard 3 stacked in sequence, the upper surface of the second paperboard 3 is provided with an information collection area 31 and a sample collection area 32, the adsorption filter paper 2 is adhered to the sample collection area 32; a collection hole 21 is provided on the adsorption filter paper 2, a collection paper sheet 22 is provided in the collection hole 21, and the outer peripheral side of the collection paper sheet 22 is connected to the hole wall of the collection hole 21 through a weak portion 23 that is easy to break; a first through hole 11 corresponding to the collection hole 21 is provided on the first paperboard 1, and the hole wall of the first through hole 11 is located on the outer peripheral side of the hole wall of the collection hole 21. In other words, the first through hole 11 is larger than the collection hole 21.

[0056] In this embodiment, by prefabricating the collection hole 21 on the adsorption filter paper 2 and connecting the collection paper sheet 22 through the easily broken weak part 23, on the one hand, it is convenient to take samples, and the collection paper sheet 22 can be removed by tweezers to achieve sampling, without the need for tools such as a puncher or scissors, thereby reducing the sample loss caused by sample acquisition; on the other hand, the interference of the hematocrit problem can be effectively reduced by the prefabricated collection paper sheet 22. The prefabricated collection paper sheet 22 can effectively block the diffusion of serum components in the blood during diffusion, and limit the effective solutes in the collection paper sheet 22. In addition, a first board paper 1 is stacked on the upper surface of the adsorption filter paper 2 to prevent the user from directly touching the adsorption filter paper 2 by mistake when using the blood sample collection card and causing contamination to the adsorption filter paper 2. The first board paper 1 is provided with a first through hole 11 corresponding to the position of the collection paper sheet 22, which can also remind the user of the location of the collection paper sheet 22, thereby improving the collection efficiency.

[0057] Specifically, the first paperboard 1 and the second paperboard 3 are made of ordinary cardboard, the adsorption filter paper 2 and the collection paper sheet 22 are made of Whatman 903 filter paper or FTA filter paper with a thickness of 0.5 mm, and high-purity cotton fiber is used as the raw material, which has good filtering performance and uniformity, can effectively remove impurities and particulate matter in the blood, and improve the accuracy and reliability of blood detection; at the same time, its material and process make it have high durability and stability, can ensure the safety and reliability of blood samples during collection, transportation and detection, of course, the adsorption filter paper 2 and the collection paper sheet 22 are also made of conventional materials for adsorbing blood samples in this field. The information collection area 31 can record the basic information of the person to be tested, such as name, gender, age, test items, blood collection date, etc. An information description area is set on the side of the second paperboard 3 away from the adsorption filter paper 2, and the instruction manual of the blood sample collection card can be filled in the information description area for the convenience of users.

[0058] More specifically, the adsorption filter paper 2 and the collection paper sheet 22 are integrally formed, and tooth-marked circles are prefabricated on the adsorption filter paper 2 to form the collection hole 21 and the weak portion 23 , as well as the collection paper sheet 22 located inside the collection hole 21 .

[0059] In this embodiment, the number of the collection holes 21 is multiple, and the multiple collection holes 21 are arranged at intervals along the length direction of the adsorption filter paper 2. By providing multiple collection holes 21 and corresponding collection paper sheets 22, the number of samples is increased. Alternatively, the multiple collection holes 21 are arranged at intervals along the width direction of the adsorption filter paper 2; or, the multiple collection holes 21 are arranged at intervals along the length direction and the width direction of the adsorption filter paper 2.

[0060] In this embodiment, if Figure 1 As shown, four collecting holes 21 are provided along the length direction of the adsorption filter paper 2. In other embodiments, eight collecting holes 21 are provided on the adsorption filter paper 2, arranged in two rows and four columns.

[0061] In this embodiment, the diameter of the collection hole 21 is 0.4cm-1.6cm, and the diameter of the first through hole 11 is 0.9cm-2.1cm, that is, the peripheral blood adsorption volume is 10-40 microliters. Preferably, the diameter of the collection hole 21 is 0.8cm to meet 20μL of peripheral blood volume.

[0062] In this embodiment, the collection paper sheet 22 and the collection hole 21 are circular in shape, which is convenient for manufacturing.

[0063] In this embodiment, if Figure 7 As shown, there are multiple weak parts 23, and the multiple weak parts 23 are evenly spaced along the circumference of the collection paper sheet 22. The connection points between the collection paper sheet 22 and the weak parts 23 are evenly located on the circumference of the collection paper sheet 22, which is convenient for tweezers to grasp the collection paper sheet 22.

[0064] Specifically, the weak portion 23 is a connecting column, and the two sides of the connecting column are respectively connected to the collection paper sheet 22 and the collection hole 21, and the number of the weak portions 23 is 4-8, and preferably, the number of the weak portions 23 is 6.

[0065] In this embodiment, if Figure 5 and Figure 6 As shown, the second paper sheet 3 is provided with a second through hole 33 corresponding to the collection hole 21, and the hole wall of the second through hole 33 is located on the outer peripheral side of the hole wall of the collection hole 21. After blood is dripped onto the collection paper sheet 22 from the front side of the second paper sheet 3, the penetration of blood on the collection paper sheet 22 can be observed through the second through hole 33 to determine whether the amount of blood collected on the collection paper sheet 22 is appropriate, so as to select a suitable collection paper sheet 22 as a sample for the next step of testing according to the penetration condition.

[0066] In this embodiment, if Figures 1 to 5As shown, the blood sample collection card also includes a cover 4, and a locking structure 34 is provided on the second paper board 3, and the locking structure 34 is configured to fix the cover 4 so that the cover 4 covers the sample collection area 32. After the blood collection is completed, the cover 4 is limited by the cooperation between the cover 4 and the locking structure 34, so that the cover 4 can cover the collection paper sheet 22 to prevent the collection paper sheet 22 from being contaminated.

[0067] In this embodiment, the end of the cover 4 is connected to one end of the second board 3 near the sample collection area 32, and a fold line 35 is provided between the cover 4 and the second board 3; the cover 4 has a first position and a second position, and the cover 4 is configured to support the second board 3 when it is in the first position, and the cover 4 is configured to flip upward relative to the second board 3 to the second position, and the locking structure 34 fixes the cover 4. The cover 4 is folded along the fold line 35 toward the front or back of the second board 3, and when the cover 4 is in the first position, as shown in FIG. Figure 1 As shown, the cover 4 is at a certain angle relative to the second paper board 3 to support the second paper board 3 to prevent the blood sample from overflowing and contacting the desktop during the dripping process; the cover 4 is flipped upward to cover the collection paper sheet 22 to avoid contamination of the collection paper sheet 22, thereby facilitating operation.

[0068] In this embodiment, if Figure 2 and Figure 3 As shown, the locking structure 34 is located between the information collection area 31 and the sample collection area 32. A trapezoidal cutout 341 is cut on the second board 3 as the locking structure 34. The trapezoidal cutout 341 is used for inserting or removing the cover 4. By directly setting the trapezoidal cutout 341 on the second board 3, the cover 4 is inserted into the trapezoidal cutout 341 to limit the cover 4, which is easy to operate.

[0069] In this embodiment, there are multiple locking structures 34, and the multiple locking structures 34 are arranged at intervals along the length direction of the adsorption filter paper 2. The cover 4 is limited by the multiple locking structures 34, and the limiting effect is good. Specifically, there are two locking structures 34, and the two locking structures 34 are symmetrically arranged.

[0070] The blood sample collection card provided in the embodiment of the utility model can be applied to tumor marker detection. The use process of the blood sample collection card is as follows:

[0071] 1. Information filling: Take out the blood sample collection card and fill in the relevant information of the person to be tested in the information collection area 31 of the second paper 3 to ensure that the information is accurate.

[0072] 2. Disinfection: Before puncture or blood collection, use alcohol cotton to wipe and disinfect the puncture point or blood collection site to reduce the risk of infection and ensure that the sample is not contaminated.

[0073] 3. Puncture: Before puncturing, you need to push the ring finger from the base of the finger 3 to 5 times, then pinch the fingertip without covering the blood collection site. This operation can greatly reduce pain and increase bleeding. Remove the blood collection needle protective cap, aim the blood collection needle at the blood collection site and press it down, the blood collection needle pops out and pierces the blood collection site.

[0074] 4. Blood collection: gently push and squeeze near the puncture site to make the blood flow out. Do not touch the blood collection site to cause contamination. After wiping off the first drop of blood with a cotton swab, use a 20μL quantitative capillary to automatically siphon until it stops to obtain a fixed amount of fresh blood. During the blood collection operation, do not squeeze the capillary balloon or cover the capillary balloon exhaust hole.

[0075] 5. Sample application: Flip the cover 4 to the first position so that the cover 4 supports the second plate paper 3, cover the capillary airbag exhaust hole with your fingers, squeeze gently, and drop the collected fresh blood into the center of the blood sample collection card collection paper 22, allowing the blood to spread around; be careful not to drop it outside the circle during the operation.

[0076] 6. Drying: Place the blood sample collection card on a clean desktop and dry it naturally for more than 30 minutes before packing it in a bag; be careful not to touch the sample collection window to prevent contamination.

[0077] 7. Storage: Flip the cover 4 to the first position and insert it into the trapezoidal cutout 341, put the dried blood sample collection card into a sealed bag containing a desiccant sheet, seal it for storage or mail it to a designated testing point for testing.

[0078] Although the specific implementations of the utility model are described above, those skilled in the art should understand that this is only an example, and the protection scope of the utility model is defined by the attached claims. Those skilled in the art can make various changes or modifications to these implementations without departing from the principle and essence of the utility model, but these changes and modifications fall within the protection scope of the utility model.

Claims

1. A blood sample collection card, characterized in that: The blood sample collection card comprises a first paperboard, an adsorption filter paper and a second paperboard stacked in sequence, wherein an information collection area and a sample collection area are arranged on the upper surface of the second paperboard, and the adsorption filter paper is adhered to the sample collection area; A collection hole is provided on the adsorption filter paper, a collection paper piece is provided in the collection hole, and the outer peripheral side of the collection paper piece is connected to the hole wall of the collection hole through a weak part that is easy to break; The first board paper is provided with a first through hole corresponding to the collection hole, and the hole wall of the first through hole is located on the outer peripheral side of the hole wall of the collection hole.

2. The blood sample collection card according to claim 1, characterized in that: There are multiple collection holes, and the multiple collection holes are arranged at intervals along the length and / or width direction of the adsorption filter paper.

3. The blood sample collection card according to claim 1, characterized in that: The diameter of the collection hole is 0.4 cm-1.6 cm, and the diameter of the first through hole is 0.9 cm-2.1 cm.

4. The blood sample collection card according to claim 1, characterized in that: The collection paper sheet and the collection hole are circular in shape.

5. The blood sample collection card according to claim 1, characterized in that: There are multiple weak parts, and the multiple weak parts are evenly spaced along the circumference of the collection paper sheet.

6. The blood sample collection card according to claim 1, characterized in that: The second board paper is provided with a second through hole corresponding to the collection hole, and the hole wall of the second through hole is located on the outer peripheral side of the hole wall of the collection hole.

7. The blood sample collection card according to claim 1, characterized in that: The blood sample collection card also includes a covering member, and a locking structure is provided on the second board paper, and the locking structure is configured to fix the covering member so that the covering member covers the sample collection area.

8. The blood sample collection card according to claim 7, characterized in that: The end of the cover is connected to one end of the second paperboard close to the sample collection area, and a fold line is provided between the cover and the second paperboard; The covering member has a first position and a second position. The covering member is configured to support the second board paper when located at the first position. The locking structure fixes the covering member when the covering member is flipped upward to the second position relative to the second board paper.

9. The blood sample collection card according to claim 8, characterized in that: The locking structure is located between the information collection area and the sample collection area. A trapezoidal cut is cut on the second board paper as the locking structure. The trapezoidal cut is used for inserting or removing the cover.

10. The blood sample collection card according to claim 7, characterized in that: There are multiple locking structures, and the multiple locking structures are arranged at intervals along the length direction of the adsorption filter paper.

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