Detection device for enriching trace substances in liquid sample by using paramagnetic particle method

By designing an automated detection device, using lifting mechanism, vortex, magnetic stand module and ultrasonic heating module, the existing magnetic bead method has solved the problem of cumbersome enrichment process for detecting trace substances, and improved the detection efficiency.

CN222882411UActive Publication Date: 2025-05-16吴志洪 +1
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Patent Information

Application Number
CN202421616949.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-07-09
Publication Date
2025-05-16
Estimated Expiration
2034-07-09

AI Technical Summary

Technical Problem

The existing magnetic bead method to detect the enrichment process of trace substances requires manual operation, which leads to cumbersome and low detection efficiency.

Method used

A detection device is designed, including a lifting mechanism, a vortex, a magnetic stand module and an ultrasonic heating module. Through automated operations, the lifting and lowering of the test tube, the shaking of the liquid and the adsorption of magnetic beads are realized.

Benefits of technology

Reduce manual operation, improve detection efficiency, and simplify the enrichment process.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses a detection device for enriching trace substances in a liquid sample by using a paramagnetic particle method, and relates to the technical field of detection of trace substances by using the paramagnetic particle method. According to the technical scheme of the utility model, a lifting mechanism, a vortex instrument, a magnetic frame module and an ultrasonic heating module are adopted, and a test tube is placed on a lifting assembly on the lifting mechanism; the vortex instrument is arranged below the lifting assembly and is used for abutting against the bottom of the test tube and vibrating the test tube; magnetic beads are placed in the test tubes, and the magnetic frame module is used for adsorbing the magnetic beads to the inner walls of the test tubes. Through the arrangement, the test tube can be lifted in place by directly utilizing the lifting mechanism, liquid in the test tube is shaken up by utilizing the vortex instrument, and magnetic beads are adsorbed to the test tube by utilizing the magnetic frame module, so that the operations of manually moving the test tube upwards, moving the test tube downwards, stirring the liquid in the test tube, fixing a magnet on the outer wall of the test tube and the like are reduced, and the detection efficiency is improved.
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Description

Technical Field

[0001] The utility model relates to the technical field of magnetic bead method for detecting trace substances, in particular to a detection device for enriching trace substances in a liquid sample by using the magnetic bead method. Background Art

[0002] In order to detect the content of trace substances in liquid samples, magnetic beads are often used to enrich the trace substances in liquid samples, so that the liquid to be tested after the enrichment process can be sampled and tested later, and the content of the trace substances can be detected.

[0003] The specific enrichment process is: move the test tube into place, stir the liquid sample in the test tube so that the liquid sample in the test tube reacts with the magnetic beads; then fix the magnet on the outer wall of the test tube to adsorb the magnetic beads in the liquid sample to the wall of the test tube, and then use a pipette to absorb the liquid separated from the magnetic beads in the test tube; after absorption, a new solvent can be dripped into the test tube, so that the trace substances attached to the magnetic beads can be dissolved into the new solvent. The enrichment process is followed by the detection process: the liquid to be tested mixed with trace substances in the test tube is sampled and tested to detect the content of the trace substances.

[0004] Since the entire enrichment process is manually operated, such as moving the test tube, stirring the liquid sample in the test tube, fixing the magnet on the outer wall of the test tube, etc., it is very cumbersome, which reduces the detection efficiency. Utility Model Content

[0005] The main purpose of the utility model is to propose a detection device for enriching trace substances in liquid samples using a magnetic bead method, aiming to solve the problem that the process of enriching trace substances in liquid samples using a magnetic bead method is manually operated, which is very cumbersome and has low detection efficiency.

[0006] In order to achieve the above-mentioned purpose, the utility model proposes a detection device for enriching trace substances in a liquid sample by using a magnetic bead method, comprising:

[0007] A lifting mechanism, the lifting mechanism comprising a first slide rail and a lifting assembly, the lifting assembly being lifted and lowered on the first slide rail;

[0008] A test tube, the test tube is placed in the lifting assembly, and magnetic beads are placed in the test tube;

[0009] A vortex instrument, the vortex instrument is arranged below the lifting assembly, and is used to abut against the bottom of the test tube and vibrate the test tube;

[0010] A magnetic frame module, the magnetic frame module is used to adsorb the magnetic beads to the inner wall of the test tube; and

[0011] The ultrasonic heating module and the magnetic frame module are arranged on two opposite sides of the lifting mechanism.

[0012] In one embodiment, the lifting assembly includes a driving device and a mounting frame, the mounting frame is movably mounted on the first slide rail, the test tube is mounted on the mounting frame, and the driving device is used to drive the mounting frame to rise and fall on the first slide rail.

[0013] In one embodiment, the lifting assembly further includes a pressure cover assembly, the mounting frame is provided with a mounting hole for mounting a test tube, the test tube is mounted in the mounting hole, the pressure cover assembly is movably mounted on the mounting frame and presses against a cover body on the test tube to seal the test tube.

[0014] In one embodiment, the cover pressing assembly includes a rotating plate and a pressing piece, the rotating plate is rotatably mounted on the mounting frame, the pressing piece is mounted on a side of the rotating plate facing the test tube, and the pressing piece presses against the cover on the test tube or separates from the cover on the test tube.

[0015] In one embodiment, an elastic member is installed between the pressing member and the rotating plate.

[0016] In one embodiment, the magnetic rack module includes a second slide rail and a magnetic clamp, the magnetic clamp is movably mounted on the second slide rail, and slides relative to the second slide rail in a direction close to the test tube or in a direction away from the test tube, and the magnetic clamp is used to adsorb the magnetic beads in the test tube.

[0017] In one embodiment, the magnetic clamping member includes a sliding portion, a first clamping member and a second clamping member, the sliding portion is slidably mounted on the second slide rail, the first clamping member and the second clamping member are mounted on the sliding portion, a clamping gap is provided between the first clamping member and the second clamping member, and the test tube is fixed in the clamping gap.

[0018] In one embodiment, the ultrasonic heating module includes a third slide rail and an ultrasonic heater, and the ultrasonic heater and the positioning seat are movably mounted on the third slide rail.

[0019] In one embodiment, the ultrasonic heating module also includes a fixed plate and a positioning seat, the ultrasonic heater and the positioning seat are installed on the fixed plate, the fixed plate is slidably installed on the third slide rail, the positioning seat is arranged on the side of the ultrasonic heater facing the test tube, the positioning seat is provided with a positioning groove, and the test tube is limited to the positioning groove.

[0020] In one embodiment, the detection device further comprises a column, wherein the column is disposed on a side of the first slide rail facing the test tube and is arranged away from the test tube, and the column is capable of supporting the mounting frame.

[0021] The technical solution of the utility model is to set a lifting mechanism, a vortex instrument, a magnetic frame module and an ultrasonic heating module. The test tube is placed on the lifting assembly on the lifting mechanism. The vortex instrument is arranged below the lifting assembly to abut against the bottom of the test tube and vibrate the test tube. Magnetic beads are placed in the test tube, and the magnetic frame module is used to adsorb the magnetic beads to the inner wall of the test tube. This arrangement allows the test tube to be directly lifted and lowered into place using the lifting mechanism, the liquid in the test tube to be shaken evenly using the vortex instrument, and the magnetic frame module to adsorb the magnetic beads to the test tube, thereby reducing the manual operations of moving the test tube up and down, stirring the liquid in the test tube, and fixing the magnet to the outer wall of the test tube, thereby improving the detection efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0023] Figure 1 A schematic structural diagram of an embodiment of a detection device for enriching trace substances in a liquid sample using a magnetic bead method provided by the utility model;

[0024] Figure 2 A structural schematic diagram of an embodiment of a lifting mechanism provided by the utility model;

[0025] Figure 3 A structural schematic diagram of an embodiment of a magnetic frame module provided by the utility model;

[0026] Figure 4 A structural schematic diagram of an embodiment of the magnetic frame module provided by the utility model from another perspective;

[0027] Figure 5 This is a schematic structural diagram of an embodiment of an ultrasonic heating module provided by the utility model.

[0028] Description of Figure Numbers:

[0029] 100. Detection device;

[0030] 10. lifting mechanism; 11. first slide rail; 12. lifting assembly; 13. driving device; 14. mounting frame; 140. mounting hole; 15. gland assembly; 150. rotating plate; 151. pressing piece; 152. elastic piece; 16. column;

[0031] 20. Test tube;

[0032] 30. Whirlpool instrument;

[0033] 40. Magnetic frame module; 41. Second slide rail; 42. Magnetic clamping member; 420. Sliding portion; 421. First clamping member; 422. Second clamping member;

[0034] 50. Ultrasonic heating module; 51. Third slide rail; 52. Ultrasonic heater; 53. Fixing plate; 54. Positioning seat; 540. Positioning groove.

[0035] The realization of the purpose, functional features and advantages of the utility model will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0037] It should be noted that if the embodiments of the present invention involve directional indications (such as up, down, left, right, front, back...), the directional indications are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indications will also change accordingly.

[0038] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the utility model, the descriptions of "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of technical features indicated. Therefore, the features limited to "first" and "second" may explicitly or implicitly include at least one of the features. In addition, if "and / or" or "and / or" appears in the full text, its meaning includes three parallel solutions. Taking "A and / or B" as an example, it includes solution A, solution B, or solutions that satisfy both A and B. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the ability of ordinary technicians in this field to implement. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such combination of technical solutions does not exist and is not within the scope of protection required by the utility model.

[0039] In the prior art, the entire enrichment process is manually operated, such as stirring operation, magnetic bead adsorption operation, etc., which is very cumbersome and inefficient.

[0040] The present invention provides a detection device 100 for enriching trace substances in a liquid sample using a magnetic bead method. Figures 1 to 5 The detection device 100 for enriching trace substances in a liquid sample by using a magnetic bead method proposed in the present invention comprises:

[0041] A lifting mechanism 10, the lifting mechanism 10 comprises a first slide rail 11 and a lifting assembly 12, the lifting assembly 12 is lifted and lowered on the first slide rail 11;

[0042] A test tube 20, the test tube 20 is placed on the lifting assembly 12, and magnetic beads are placed in the test tube 20;

[0043] A vortex meter 30, which is disposed below the lifting assembly 12 and is used to abut against the bottom of the test tube 20 and vibrate the test tube 20;

[0044] A magnetic frame module 40, which is used to adsorb magnetic beads to the inner wall of the test tube 20; and

[0045] The ultrasonic heating module 50 and the magnetic frame module 40 are disposed on two opposite sides of the lifting mechanism 10 .

[0046] In one embodiment of the utility model, the test tube 20 is mounted on the lifting assembly 12 of the lifting mechanism 10, and the lifting assembly 12 is lifted and lowered on the first slide rail 11, thereby being able to drive the test tube 20 to be lifted and lowered, without the need to manually move the test tube 20 up or down, which saves time and effort. Specifically, the lifting assembly 12 includes a driving device 13 and a mounting frame 14, the mounting frame 14 is movably mounted on the first slide rail 11, the test tube 20 is mounted on the mounting frame 14, and the driving device 13 is used to drive the mounting frame 14 to be lifted and lowered on the first slide rail 11.

[0047] The technical solution of the utility model adopts the arrangement of a lifting mechanism 10, a vortex instrument 30, a magnetic frame module 40 and an ultrasonic heating module 50. The test tube 20 is placed on the lifting assembly 12 on the lifting mechanism 10. The vortex instrument 30 is arranged below the lifting assembly 12 to abut against the bottom of the test tube 20 and vibrate the test tube 20. Magnetic beads are placed in the test tube 20, and the magnetic frame module 40 is used to adsorb the magnetic beads to the inner wall of the test tube 20. With such an arrangement, the test tube 20 can be directly lifted and lowered into place by the lifting mechanism 10, the liquid in the test tube 20 can be shaken by the vortex instrument 30, and the magnetic frame module 40 can be used to adsorb the magnetic beads to the test tube 20, thereby reducing the manual operations of moving the test tube 20 up and down, stirring the liquid in the test tube 20, and fixing the magnet to the outer wall of the test tube 20, thereby improving the detection efficiency.

[0048] The operation process of the detection device 100 is as follows: install the test tube 20 on the lifting assembly 12, drip the liquid sample into the test tube 20 and put the magnetic beads; then, set the vortex meter 30 below the lifting assembly 12, turn on the driving device 13 to control the mounting frame 14 to descend on the first slide rail 11 toward the vortex meter 30, so as to drive the test tube 20 to descend toward the vortex meter 30. The mounting frame 14 stops descending until the bottom of the test tube 20 collides with the vortex meter 30. Turn on the vortex meter 30. Since the bottom of the test tube 20 collides with the vortex meter 30, the vortex meter 30 can oscillate and shake the liquid sample in the test tube 20 when it is working, so that the magnetic beads in the test tube 20 react with the liquid sample and the magnetic beads adhere to the trace substances.

[0049] Afterwards, the driving device 13 controls the mounting frame 14 to rise in the direction away from the vortex instrument 30 on the first slide rail 11, so as to drive the test tube 20 to rise in the direction away from the vortex instrument 30. The mounting frame 14 stops rising until the test tube 20 is completely separated from the vortex instrument 30.

[0050] Next, the magnetic frame module 40 is used to adsorb the magnetic beads in the test tube 20 so as to adsorb the magnetic beads to the inner wall of the test tube 20 , thereby facilitating the subsequent use of a pipette to suck away the liquid separated from the magnetic beads in the test tube 20 , and retain the magnetic beads in the test tube 20 .

[0051] After the liquid in the test tube 20 is sucked out, a new solvent is dripped in, the magnetic frame module 40 is separated from the test tube 20, and the trace substances attached to the magnetic beads are dissolved in the new solvent.

[0052] Since the vortexer 30 can be used to vibrate the test tube 20 directly to oscillate and evenly shake the liquid sample in the test tube 20, there is no need to manually stir the liquid in the test tube 20. The magnetic frame module 40 can also be used directly to adsorb the magnetic beads in the test tube 20, reducing the need to manually fix the magnet to the outer wall of the test tube 20.

[0053] It should be noted that the magnetic bead method for adsorbing trace substances in liquid samples is an existing technology, and the reaction principle will not be described in detail here.

[0054] The test tube 20 may be provided with an injection tube so that a liquid sample or other liquid may be added thereto through the injection tube.

[0055] See also Figure 1 and Figure 2 The lifting assembly 12 includes a driving device 13 and a mounting frame 14 . The mounting frame 14 is movably mounted on the first slide rail 11 . The test tube 20 is mounted on the mounting frame 14 . The driving device 13 is used to drive the mounting frame 14 to move up and down on the first slide rail 11 .

[0056] In one embodiment of the utility model, the driving device 13 is a motor. The motor drives the mounting frame 14 to rise and fall on the first slide rail 11, thereby driving the test tube 20 to rise and fall, without the need for manual up or down movement of the test tube 20, which saves time and effort.

[0057] In order to seal the test tube 20 , the lifting assembly 12 also includes a cover assembly 15 . The mounting frame 14 is provided with a mounting hole 140 for mounting the test tube 20 . The test tube 20 is mounted in the mounting hole 140 . The cover assembly 15 is movably mounted on the mounting frame 14 and presses against the cover body on the test tube 20 to seal the test tube 20 .

[0058] In one embodiment of the utility model, the test tube 20 is installed into the mounting hole 140 of the mounting frame 14, the cover on the test tube 20 is closed, and then the cover on the test tube 20 is pressed against by the pressure cover assembly 15 to ensure that the cover on the test tube 20 is firmly fixed on the test tube 20, so as to avoid the situation that when the vortex instrument 30 vibrates the test tube 20, the cover on the test tube 20 is loosened and separated from the test tube 20.

[0059] See also Figure 1 and Figure 2 In order to facilitate the operation of the cover pressing assembly 15, the cover pressing assembly 15 includes a rotating plate 150 and a pressing piece 151. The rotating plate 150 is rotatably mounted on the mounting frame 14, and the pressing piece 151 is installed on the side of the rotating plate 150 facing the test tube 20. The pressing piece 151 presses against the cover body on the test tube 20 or is separated from the cover body on the test tube 20.

[0060] In one embodiment of the present invention, the pressing member 151 is installed at the bottom of the rotating plate 150. The rotating plate 150 is rotated toward the test tube 20 to drive the pressing member 151 to rotate, so that the pressing member 151 can press against the cover of the test tube 20.

[0061] When the test tube 20 needs to be taken out, the rotating plate 150 can be rotated away from the test tube 20 , and the rotating plate 150 drives the pressing piece 151 to rotate away from the test tube 20 , and the pressing piece 151 is separated from the test tube 20 , thereby facilitating the test tube 20 to be taken out from the mounting hole 140 .

[0062] In order to prevent the pressing member 151 from damaging the cover of the test tube 20 , an elastic member 152 is installed between the pressing member 151 and the rotating plate 150 .

[0063] In one embodiment of the present invention, the elastic member 152 is a spring. A spring is installed between the pressing member 151 and the rotating plate 150 to prevent the pressing member 151 from excessively pressing against the cover of the test tube 20, thereby preventing the pressing member 151 from damaging the cover of the test tube 20.

[0064] See also Figure 1 , Figure 3 and Figure 4 The magnetic frame module 40 includes a second slide rail 41 and a magnetic clamp 42. The magnetic clamp 42 is movably mounted on the second slide rail 41 and slides toward the test tube 20 or away from the test tube 20 relative to the second slide rail 41. The magnetic clamp 42 is used to adsorb the magnetic beads in the test tube 20.

[0065] In one embodiment of the utility model, a motor is installed on the second slide rail 41, and the motor is used to drive the magnetic clamp 42 to move on the second slide rail 41. Since the motor can drive the magnetic clamp 42 to move on the second slide rail 41 toward the test tube 20, there is no need to manually fix the magnetic clamp 42 to the test tube 20, which saves time and effort.

[0066] Specifically, see Figure 4 In order to adsorb the magnetic beads in the test tube 20 onto the inner wall surface of the test tube 20, the magnetic clamping member 42 includes a sliding part 420, a first clamping member 421 and a second clamping member 422. The sliding part 420 is slidably installed on the second slide rail 41, the first clamping member 421 and the second clamping member 422 are installed on the sliding part 420, and there is a clamping gap between the first clamping member 421 and the second clamping member 422, and the test tube 20 is fixed in the clamping gap.

[0067] In one embodiment of the utility model, magnets are installed on the first clamping member 421 and the second clamping member 422 of the magnetic clamping member 42. The magnetic clamping member 42 is driven by a motor to move on the second slide rail 41 toward the test tube 20, and the test tube 20 is located in the clamping gap between the first clamping member 421 and the second clamping member 422. The first clamping member 421 and the second clamping member 422 adsorb the magnetic beads in the test tube 20 onto the inner wall surface of the test tube 20, thereby facilitating the subsequent use of a straw to absorb the liquid separated from the magnetic beads in the test tube 20.

[0068] Furthermore, after the liquid in the test tube 20 is completely absorbed, a new solvent can be dripped in. Then, the magnetic clamp 42 is driven by the motor to move on the second slide rail 41 in a direction away from the test tube 20, the first clamp 421 and the second clamp 422 are away from the test tube 20, and the magnetic beads fall back into the new solvent in the test tube 20.

[0069] The new solvent may be a cleaning agent. The cleaning agent is added to the test tube 20 to wash off the trace substances on the magnetic beads and dissolve them in the cleaning agent.

[0070] To make the trace substances attached to the magnetic beads dissolve quickly into the new solvent, please refer to Figure 1 and Figure 5 The ultrasonic heating module 50 includes a third slide rail 51 and an ultrasonic heater 52 . The ultrasonic heater 52 and a positioning seat 54 are movably mounted on the third slide rail 51 .

[0071] In one embodiment of the utility model, the ultrasonic heater 52 and the magnetic frame module 40 are located on both sides of the test tube 20. The ultrasonic heater 52 is movably mounted on the third slide rail 51, and a motor is mounted on the third slide rail 51, and the motor is used to drive the ultrasonic heater 52 to move on the third slide rail 51. The ultrasonic heater 52 can be used to heat the liquid in the test tube 20 to which the new solvent is added, so that the trace substances attached to the magnetic beads are dissolved in the new solvent more quickly.

[0072] In order to limit the test tube 20 and facilitate the ultrasonic heater 52 to heat the liquid with the new solvent added into the test tube 20, the ultrasonic heating module 50 also includes a fixed plate 53 and a positioning seat 54. The ultrasonic heater 52 and the positioning seat 54 are installed on the fixed plate 53. The fixed plate 53 is slidably installed on the third slide rail 51. The positioning seat 54 is arranged on the side of the ultrasonic heater 52 facing the test tube 20. The positioning seat 54 is provided with a positioning groove 540. The test tube 20 is limited to the positioning groove 540.

[0073] The positioning seat 54 is provided with a through hole corresponding to the ultrasonic heater 52. In order to fix the test tube 20 so as to heat the test tube 20, the test tube 20 can be raised, and then the ultrasonic heater 52 and the positioning seat 54 can be driven to move toward the test tube 20; then the test tube 20 is lowered so that the test tube 20 falls into the positioning seat 54, and the ultrasonic heater 52 heats the liquid with the new solvent dripped into the test tube 20 in the positioning seat 54.

[0074] In an embodiment of the present invention, the detection device 100 further includes a column 16 . The column 16 is disposed on a side of the first slide rail 11 facing the test tube 20 and away from the test tube 20 . The column 16 can support the mounting frame 14 .

[0075] Please refer to Figure 2The column 16 is disposed below the mounting frame 14 and at the other end of the mounting frame 14. One end of the mounting frame 14 is movably mounted on the first slide rail 11. The column 16 can be used not only to support the mounting frame 14 but also to limit the range of the mounting frame 14 to be lowered. Specifically, when the mounting frame 14 is lowered and hits the column 16, the column 16 supports the mounting frame 14 and blocks the mounting frame 14 from moving downward.

[0076] The above description is only an exemplary embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification and drawings under the technical concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A detection device for enriching trace substances in a liquid sample using a magnetic bead method, characterized in that: include: A lifting mechanism, the lifting mechanism comprising a first slide rail and a lifting assembly, the lifting assembly being lifted and lowered on the first slide rail; A test tube, the test tube is placed in the lifting assembly, and magnetic beads are placed in the test tube; A vortex instrument, the vortex instrument is arranged below the lifting assembly, and is used to abut against the bottom of the test tube and vibrate the test tube; A magnetic frame module, the magnetic frame module is used to adsorb the magnetic beads to the inner wall of the test tube; as well as The ultrasonic heating module and the magnetic frame module are arranged on two opposite sides of the lifting mechanism.

2. The detection device according to claim 1, characterized in that The lifting assembly includes a driving device and a mounting frame. The mounting frame is movably mounted on the first slide rail, the test tube is mounted on the mounting frame, and the driving device is used to drive the mounting frame to move up and down on the first slide rail.

3. The detection device according to claim 2, characterized in that: The lifting assembly also includes a pressure cover assembly. The mounting frame is provided with a mounting hole for mounting a test tube. The test tube is mounted in the mounting hole. The pressure cover assembly is movably mounted on the mounting frame and presses against a cover body on the test tube to seal the test tube.

4. The detection device according to claim 3, characterized in that: The cover pressing assembly includes a rotating plate and a pressing piece. The rotating plate is rotatably mounted on the mounting frame. The pressing piece is mounted on a side of the rotating plate facing the test tube. The pressing piece presses against the cover on the test tube or is separated from the cover on the test tube.

5. The detection device according to claim 4, characterized in that: An elastic member is installed between the pressing member and the rotating plate.

6. The detection device according to any one of claims 1 to 5, characterized in that: The magnetic frame module includes a second slide rail and a magnetic clamp, which is movably mounted on the second slide rail and slides toward the test tube or away from the test tube relative to the second slide rail. The magnetic clamp is used to absorb the magnetic beads in the test tube.

7. The detection device according to claim 6, characterized in that: The magnetic clamping member includes a sliding part, a first clamping member and a second clamping member. The sliding part is slidably installed on the second slide rail, the first clamping member and the second clamping member are installed on the sliding part, a clamping gap is provided between the first clamping member and the second clamping member, and the test tube is fixed in the clamping gap.

8. The detection device according to any one of claims 1 to 5, characterized in that: The ultrasonic heating module comprises a third slide rail and an ultrasonic heater, and the ultrasonic heater and a positioning seat are movably mounted on the third slide rail.

9. The detection device according to claim 8, characterized in that: The ultrasonic heating module also includes a fixing plate and a positioning seat, the ultrasonic heater and the positioning seat are installed on the fixing plate, the fixing plate is slidably installed on the third slide rail, the positioning seat is arranged on the side of the ultrasonic heater facing the test tube, the positioning seat is provided with a positioning groove, and the test tube is limited to the positioning groove.

10. The detection device according to any one of claims 2 to 5, characterized in that: The detection device further comprises a column, which is arranged on a side of the first slide rail facing the test tube and is arranged away from the test tube, and the column can support the mounting frame.