Fixing device
By designing an adjustable fixture, combined with the insulation assembly and fixing sheet, the problem of the fixture in the prior art is not adjustable, lacking insulation function and poor fixation of mouse tails, and achieving a more efficient and safe mouse tail vein injection operation.
Patent Information
- Application Number
- CN202421384737.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Priority Date
- 2023-06-19
- Filing Date
- 2024-06-18
- Publication Date
- 2025-05-23
- Estimated Expiration
- 2034-06-18
AI Technical Summary
The existing mouse tail vein injection fixation device cannot dynamically adjust the size, lacks insulation function, is costly, and cannot effectively fix the mouse tail, resulting in difficulty in handling and harm to the mice.
An adjustable size fixing device is designed, including a first adjustment unit and a second adjustment unit, capable of adapting to mice of different body types, and equipped with a thermal insulation assembly and a fixing sheet to fix the mouse tail.
Stable fixation of mice of different body sizes is achieved, the accuracy and efficiency of injection is improved, the harm to mice is reduced, and the experimental cost and management difficulty is reduced.
Smart Images
Figure CN222889064U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of animal experimental equipment, in particular to a fixing device. Background Art
[0002] In the research of life sciences, mice are usually selected as experimental subjects, and tail vein injection is one of the commonly used methods for mouse experiments. However, mice have strong mobility and need to be fixed during tail vein injection, so the mouse tail vein injection fixture is indispensable in scientific research. Generally, the mouse tail vein injection fixture is cylindrical, with a round hole at one end, through which the mouse extends its tail for easy injection. In this way, biological agents can be injected to reach the systemic circulation to achieve the experimental purpose of the research. However, the tail vein of the mouse is thin, and injection is often difficult, and the fixation operation needs to be performed with caution to avoid harming the mouse.
[0003] At present, most of the mouse tail vein injection fixtures have some defects and shortcomings, which are mainly reflected in the following four aspects: First, the size of the existing injection fixture is fixed and cannot be dynamically adjusted according to the size of the mouse. It is usually necessary to prepare multiple fixtures of different specifications, which increases the experimental cost and management difficulty. Secondly, most injection fixtures cannot provide insulation function. Especially in low temperature environments, the mouse blood vessels shrink and become thinner, which will increase the difficulty of mouse tail vein injection and limit the accuracy of injection. Third, the existing injection fixtures are usually expensive and require expensive equipment and instruments to use, which is not conducive to the experimental development and resource utilization of scientific researchers. Finally, the existing fixture cannot fix the mouse tail, and it needs to be manually fixed during the injection, which may cause a certain degree of pain to the mouse, and also increase the work intensity and operation difficulty of scientific researchers when the mouse responds to stress.
[0004] Therefore, further research and improvement are needed to address these issues and develop a more intelligent, convenient and humane mouse tail vein injection fixation device to improve the accuracy and efficiency of experimental operations and the protection of mice, while reducing experimental costs and management difficulties. Utility Model Content
[0005] Purpose of the utility model: The utility model provides a fixing device, which is used for fixing mice and is suitable for fixing mice of different sizes.
[0006] Technical solution: A fixing device according to the utility model comprises a main body, the main body is a hollow cylinder, the main body has a first edge and a second edge, the first edge and the second edge extend along a first direction X, and there is a distance between the first edge and the second edge; a first positioning device is arranged on the main body;
[0007] At least one first adjusting unit, wherein the first adjusting unit surrounds the main body, and the diameter of the main body is adjusted by adjusting the diameter of the first adjusting unit;
[0008] A second adjusting unit, the second adjusting unit comprising a limiting plate and a push rod for adjusting the position of the limiting plate along the first direction X, and a second positioning device is fixed on the limiting plate;
[0009] The second positioning device cooperates with the first positioning device to fix the second adjusting unit.
[0010] As a preferred embodiment of the present application, the first positioning device includes a guide rail opened on the main body and extending along the first direction X, and a first fixing hole, the first fixing hole is arranged along the direction in which the guide rail extends, and the diameter of the first fixing hole is greater than the width of the guide rail.
[0011] As a preferred embodiment of the present application, the first adjustment unit includes a fixing ring and a fixing screw arranged on the fixing ring, the fixing ring has an external thread, the fixing screw has a second fixing hole and a third fixing hole, the second fixing hole is connected to the first end of the fixing ring, and the third fixing hole is connected to the second end of the fixing ring.
[0012] As a preferred embodiment of the present application, the second positioning device includes a fixing cap, a connecting rod connected to the fixing cap, and an adjusting member fixed to the connecting rod; the connecting rod passes through the cylindrical wall of the main body, and the diameter of the connecting rod gradually decreases along the second direction Y.
[0013] As a preferred embodiment of the present application, the adjusting member includes a spring, and the adjusting member is used to adjust the position of the connecting rod in the second direction Y.
[0014] As a preferred embodiment of the present application, it includes a thermal insulation component, which includes a thermal insulation piece and a through hole arranged on the thermal insulation component.
[0015] As a preferred embodiment of the present application, it includes a base, and the thermal insulation component is fixed to the base.
[0016] As a preferred embodiment of the present application, it includes a fixing plate, and the fixing plate is connected to the heat preservation component through a fixing rope.
[0017] Beneficial effects: Compared with the prior art, the fixing device of the present application has the following advantages: (1) The fixing device of the present application is adjustable in size. The present application adjusts the diameter of the fixing device body through the first adjustment unit, and simultaneously uses the push rod in the second adjustment unit to adjust the position of the limit plate forward and backward, so as to adapt to the fixation of mice of different sizes and is easy to use; (2) The present application further uses the fixing plate to fix the tail of the mouse, thereby solving the defect that the existing fixing device is not humanized enough or has imperfect functions, resulting in the inability to effectively fix the tail of the mouse. The fixing plate of the present application, as a tail support component, can fix the tail of the mouse to prevent accidental injury caused by hand shaking or improper operation; (3) The fixing device of the present application is more convenient, improves the accuracy and efficiency of injection, and reduces damage to the mouse; (4) The fixing device of the present application is easy to use, reduces the difficulty of operation in the experiment, and can improve the accuracy and work efficiency of the experiment; (5) The heat preservation component of the present application can provide a heat preservation function, so that the mouse blood vessels are dilated, which is convenient for injection operation, and solves the defect that the existing fixing device cannot provide a heat preservation function, especially in cold weather, the mouse blood vessels shrink and become thinner, which increases the difficulty and time of operation. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] Figure 1 This is a schematic diagram of the structure of the fixing device in the embodiment of the present application;
[0019] Figure 2 A top view of the fixing device body in the embodiment of the present application;
[0020] Figure 3 This is a schematic diagram of the structure of the fixing screw in the embodiment of the present application;
[0021] Figure 4 This is a schematic diagram of the structure after the fixing ring is unfolded in the embodiment of the present application;
[0022] Figure 5 Schematic diagram of the structure of the second positioning device in the embodiment of the present application. DETAILED DESCRIPTION
[0023] The solution of the utility model is further described below in conjunction with the accompanying drawings of the specification.
[0024] The existing fixtures for fixing experimental animals such as mice have at least the following problems: first, the size of the fixture cannot be adjusted; second, it cannot provide a heat preservation function, especially in a low temperature environment, which causes the mouse's blood vessels to contract, which will cause difficulties for the mouse's tail vein injection, limiting the accuracy of the experimental operation; third, the cost is high, which is not conducive to the experimental development and resource utilization of scientific researchers; fourth, there are safety hazards. The existing fixture cannot fix the mouse's tail, and manual fixation is required during the injection, which may cause a certain degree of pain and stress to the mouse, and also increase the work intensity and operation difficulty of scientific researchers, and increase the risk factor of scientific research work. In response to these problems, the present application provides a low-cost fixture for mouse tail vein injection, which is used to fix experimental mice, improves the accuracy, efficiency and protection of experimental operations to mice, and reduces experimental costs and management difficulties.
[0025] like Figure 1 As shown, the fixing device described in the embodiment of the utility model has a first direction X, a second direction Y and a third direction Z that are perpendicular to each other. The fixing device of the embodiment of the present application includes a main body 100, and the main body 100 is a hollow cylinder. The main body 100 has a first edge 110 and a second edge 120. The first edge 110 and the second edge 120 extend along the first direction X, and there is a distance between the first edge 110 and the second edge 120, and the distance between the first edge 110 and the second edge 120 can be adjusted.
[0026] In some embodiments, the main body 100 is composed of a transparent plastic tube, which has a certain hardness and elasticity. The main body 100 is cut along the first direction X to form a first edge 110 and a second edge 120, so that the first edge 110 and the second edge 120 have a certain distance, which is convenient for adjusting the diameter of the cylinder.
[0027] like Figure 2 As shown, the main body 100 is provided with a first positioning device 103, and the first positioning device 103 provided on the cylinder includes a guide rail 1031 and a first fixing hole 1032 which are provided on the main body 100 and extend along the first direction X. The first fixing hole 1032 is provided along the extending direction of the guide rail 1031, and the diameter of the first fixing hole 1032 is greater than the width of the guide rail 1031. The first fixing hole 1032 is used to clamp the second positioning device 303 to realize the position positioning of the second positioning device 303.
[0028] like Figure 3 and Figure 4As shown, at least one first adjustment unit 200 is disposed on the main body 100 of the present application. In some specific embodiments, two first adjustment units 200 are disposed on the main body 100, and the two first adjustment units 200 are disposed at intervals along the first direction X. The first adjustment unit 200 surrounds the outer circumference of the main body 100, and the diameter of the main body 100 is adjusted by adjusting the diameter of the first adjustment unit 200. In some embodiments, the first adjustment unit 200 includes a fixing ring 201 and a fixing screw 202 disposed on the fixing ring 201, the fixing ring 201 has an external thread, and the fixing screw 202 has a second fixing hole 2021 and a third fixing hole 2022, the second fixing hole 2021 is connected to the first end 2011 of the fixing ring 201, and the third fixing hole 2022 is connected to the second end 2012 of the fixing ring 201. In some specific embodiments, the fixing ring 201 is wound around the barrel, and the second fixing hole 2021 of the fixing screw 202 is connected to the first end 2011. The first end 2011 is used as a fixing end, and it only rotates in the circumferential direction (ZX plane) around the second fixing hole 2021, and does not serve as a length adjustment end. The second end 2012 is used as an adjustment end, and it is connected to the third fixing hole 2022 provided with an internal thread. Through the external thread provided by the fixing ring 201, the diameter of the first adjustment unit 200 can be adjusted by the fixing screw 202 and the fixing ring 201. The two first adjustment units 200 are fixed one after the other, so that the mouse is more stable in the fixing device and the activity space of the mouse is better limited. In this way, it can be adjusted according to the size of the mouse with different weights to ensure that the cross-sectional size of the fixing device is appropriate, and it will not cause harm to the mouse and will not affect the injection effect.
[0029] like Figure 1 and Figure 5 As shown, the fixing device of the present application also includes a second adjusting unit 300, which includes a limiting plate 301 and a push rod 302 for adjusting the position of the limiting plate 301 along the first direction X. The push rod 302 is fixedly connected to the limiting plate 301, and a second positioning device 303 is fixed on the limiting plate 301. The second positioning device 303 extends along the second direction Y. The second positioning device 303 cooperates with the first positioning device 103 to adjust the position of the second adjusting unit 300.
[0030] In some embodiments, Figure 5As shown, the second positioning device 303 includes a fixing cap 3031, a connecting rod 3032 connected to the fixing cap 3031, and an adjusting member 3033 fixed to the connecting rod 3032. In some specific embodiments, the adjusting member 3033 is a spring, which is in a compressed state and presses upward against the lower end of the connecting rod 3032; the connecting rod 3032 passes through the cylinder wall of the main body 100, and the diameter of the connecting rod 3032 gradually decreases along the second direction Y. In some specific embodiments, the connecting rod 3032 passes through the first fixing hole 1032, and the connecting rod 3032 is fixed through the first fixing hole 1032 to locate the position of the second positioning device 303 in the first direction X. In a specific application, the adjusting member 303 arranged at the bottom presses upward against the connecting rod 3032, and the connecting rod 3032 presses against the first fixing hole 1032, which has a larger diameter than the guide rail 1031, so that it does not move forward and backward. When the second adjustment unit 300 needs to be moved forward and backward, the connecting rod 3032 is pressed downward by the fixing cap 3031 to further compress the spring. As the connecting rod 3032 moves downward, the diameter of the connecting rod 3032 at the upper end becomes smaller. At this time, the connecting rod 3032 can move forward and backward with the guide rail 1031 until it reaches the first fixing hole 1032 at a suitable position, thereby adjusting the position of the second adjustment unit 300 in the first direction X. The second positioning device 303 of the present application fixes mice of different sizes by clamping the first fixing holes 1031 at different positions on the first positioning device 103 in the first direction X. It can be seen that the present application can fix mice of different lengths.
[0031] The fixing device of the present application adjusts the second adjusting unit 300 to clamp the first fixing hole at different positions, so that the tail of the mouse is exposed, thereby facilitating the injection operation. In some embodiments, the side of the connecting rod 3032 is fixed to the limiting plate 301, so that the limiting plate 301 moves with the movement of the connecting rod 3032. The present application can better fix mice of different sizes by using the first adjusting unit 200 and the second adjusting unit 300 in combination.
[0032] like Figure 1As shown, the fixing device of the present application also includes a heat preservation component 400, a base 500 and a fixing plate 600. The heat preservation component 400 includes a heat preservation part 401 and a through hole 402 arranged on the heat preservation component 400. The heat preservation component 400 is fixed to the base 500, and the fixing plate 600 is connected to the heat preservation component 400 by a fixing rope 601. In some embodiments, the heat preservation component 400 is composed of a hollow flat plate, into which hot water can be injected through the through hole 402, and the temperature of the environment where the mouse is located is improved, thereby causing the mouse blood vessels to dilate, facilitating the injection operation, and increasing the injection success rate. In other embodiments, the heat preservation component 400 can also be made of a flexible material, such as a hot water insulation bag made of a hollow rubber material, and the through hole 402 is used as a water inlet. Before injection, after adding an appropriate amount of warm water to the water inlet, the hot water bag is rolled up and wrapped around the main body 100, thereby providing a heat preservation function for the mouse. In addition, the through hole 402 of the present application can be sealed in any manner that can achieve the purpose of the present application, such as sealing the through hole 402 with a rubber plug. When the insulation component 400 of the present application is made of a flexible material, a support plate can be provided below the insulation component 400, and the fixing sheet 600 is fixed to the support plate by a fixing rope 601.
[0033] In some embodiments, the base 500 is connected to the main body 100 via a rotating shaft 501 , and the angle of the rotating shaft 501 can be adjusted to thereby adjust the angle of the main body 100 , making it easier for experimenters to operate.
[0034] In some embodiments, the fixing sheet 600 is composed of a cardboard, and the fixing rope 601 can be a plastic iron wire. During the injection, the plastic iron wire is used to support and drive the cardboard. The mouse's tail can be fixed on the cardboard with two medical tapes, one above and one below. The space in the middle is used for injection. The iron wire is fine-tuned to find an angle that is conducive to injection. The left hand gently supports the cardboard, and the right hand starts the tail vein injection. This prevents accidental injuries caused by hand shaking or improper operation.
[0035] From the above description, it can be seen that the fixing device of the present application can provide a more convenient and user-friendly operating experience, alleviate and solve some problems and shortcomings of existing fixing devices, while improving the accuracy and efficiency of injection and reducing damage to mice.
[0036] In some embodiments, the fixing device of the present application is used in the following manner:
[0037] First, the tail of the mouse is exposed through the tip of the bottom of the centrifuge tube, and the first adjustment is performed. According to the length of the mouse, the spring in the second adjustment device 300 is pressed downward, and the handle is pushed forward and backward to adjust the position of the second fixing device 300 so that the connecting rod 3032 is stuck in the appropriate position of the first fixing hole 1031 to fix the mouse. After the mouse is fixed inside the main body 100, the second adjustment is performed, and the tightness of the first fixing device 200 is adjusted using the fixing screw 202 to achieve a more secure fixing effect. The temperature is adjusted according to environmental issues. When the temperature is too low or the venous dilation of the mouse is not good, warm water is added through the water injection port, and the insulation component 400 is rolled up and covered on the outer periphery of the main body 100, thereby providing a warm environment for the mouse, achieving a heat preservation effect, and dilating the mouse blood vessels. Next, the inclination angle of the support shaft 501 is adjusted to make the mouse tail tilt downward, and the position of the plastic iron wire is adjusted to make the cardboard have a certain inclination, which is convenient for fixing the mouse tail. A medical tape is attached to the upper and lower parts of the mouse tail to make it stable, fixed on the cardboard, and the iron wire or the support shaft angle is fine-tuned to reach a suitable injection position. Hold the cardboard lightly with your left hand and start tail vein injection with your right hand. The whole process needs to be very careful to avoid causing harm to the mouse.
[0038] In summary, compared with the prior art, the present application has the advantages of improving operating efficiency, improving injection accuracy, reducing experimental costs, and improving experimental results.
Claims
1. A fixing device, characterized in that: The invention comprises a main body (100), the main body (100) being a hollow cylinder, the main body (100) having a first edge (110) and a second edge (120), the first edge (110) and the second edge (120) extending along a first direction (X), and a distance between the first edge (110) and the second edge (120); and a first positioning device (103) being arranged on the main body (100); At least one first adjustment unit (200), the first adjustment unit (200) surrounding the main body (100), and the diameter of the main body (100) is adjusted by adjusting the diameter of the first adjustment unit (200); A second adjustment unit (300), the second adjustment unit (300) comprising a limiting plate (301) and a push rod (302) for adjusting the position of the limiting plate (301) along a first direction (X), and a second positioning device (303) is fixed on the limiting plate (301); The second positioning device (303) cooperates with the first positioning device (103) and is used to fix the second adjustment unit (300).
2. The fixing device according to claim 1, characterized in that: The first positioning device (103) comprises a guide rail (1031) opened on the main body (100) and extending along a first direction (X), and a first fixing hole (1032), wherein the first fixing hole (1032) is arranged along the direction in which the guide rail (1031) extends, and the diameter of the first fixing hole (1032) is greater than the width of the guide rail (1031).
3. The fixing device according to claim 1, characterized in that: The first adjustment unit (200) comprises a fixing ring (201) and a fixing screw (202) arranged on the fixing ring (201), the fixing ring (201) having an external thread, the fixing screw (202) having a second fixing hole (2021) and a third fixing hole (2022), the second fixing hole (2021) being connected to a first end (2011) of the fixing ring (201), and the third fixing hole (2022) being connected to a second end (2012) of the fixing ring (201).
4. The fixing device according to claim 1, characterized in that: The second positioning device (303) comprises a fixing cap (3031), a connecting rod (3032) connected to the fixing cap (3031), and an adjusting member (3033) fixed to the connecting rod (3032); the connecting rod (3032) passes through the cylindrical wall of the main body (100), and the diameter of the connecting rod (3032) gradually decreases along the second direction (Y).
5. The fixing device according to claim 4, characterized in that: The adjusting member (3033) comprises a spring, and the adjusting member (3033) is used to adjust the position of the connecting rod (3032) in the second direction (Y).
6. The fixing device according to claim 1, characterized in that: The invention comprises a heat-insulating component (400), wherein the heat-insulating component (400) comprises a heat-insulating part (401) and a through hole (402) arranged on the heat-insulating component (400).
7. The fixing device according to claim 6, characterized in that: It comprises a base (500), and the heat preservation component (400) is fixed to the base (500).
8. The fixing device according to claim 6, characterized in that: It comprises a fixing plate (600), wherein the fixing plate (600) is connected to the heat-insulating component (400) via a fixing rope (601).