DNA synthesis column

Abstract

The utility model discloses a DNA (Deoxyribose Nucleic Acid) synthesis column which comprises a column tube, a cover plate is arranged at the upper end of a column tube, the bottom end of the cover plate covers the upper end of the column tube, a soft connecting piece is mounted on one side of the cover plate, a lantern ring is mounted on one side of the soft connecting piece and sleeves the upper side of the column tube, a solid-phase carrier is mounted in the column tube, a socket is arranged at the bottom end of the column tube, the bottom end of the column tube is inserted into the socket, and a bottom plate is mounted at the bottom end of the socket. The upper end of the column pipe is provided with a lead-in port, and the bottom end of the column pipe is provided with a lead-out port. According to the utility model, the column tube can be placed in the socket after addition is completed or during intermediate intermittence, so that the column tube can be placed vertically and is very convenient, and the cover plate can seal the column tube when not in use, so that dust is prevented from entering the column tube.

Description

Technical Field

[0001] The utility model relates to the technical field of synthesis columns, in particular to a DNA synthesis column. Background Art

[0002] With the rapid development of synthetic biology, functional genomics, proteomics, and clinical diagnostics, massive DNA synthesis is required, and rapid gene synthesis has become a hot topic in synthetic biology. DNA synthesis columns are required in the process of DNA synthesis.

[0003] Chinese patent number CN201820110443.X discloses a DNA synthesis column, including a column tube, a solid phase carrier arranged in the column tube, the solid phase carrier is divided into a first solid phase carrier and a second solid phase carrier arranged up and down, the inner cavity of the column tube is from top to bottom, an inlet, a first liquid storage cavity, a first fixed cavity, a second liquid storage cavity, a second fixed cavity, and a liquid outlet, the first solid phase carrier is stuck in the first fixed cavity, the second solid phase carrier is stuck in the second fixed cavity, and the inner diameters of the first liquid storage cavity and the second liquid storage cavity are uniformly narrowed from top to bottom. In the process of using the prior art, the synthesis column is openly arranged to avoid dust from entering the column tube during transportation and placement, and the column tube is generally placed upside down, which is very inconvenient. Utility Model Content

[0004] The utility model aims to provide a DNA synthesis column to solve the problems raised in the prior art.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a DNA synthesis column, comprising a column tube; a cover plate is arranged at the upper end of the column tube, the bottom end of the cover plate covers the upper end of the column tube, a soft connector is installed at one side of the cover plate, a sleeve is installed at one side of the soft connector, the sleeve is sleeved at the upper side of the column tube, a solid phase carrier is installed inside the column tube, a socket is arranged at the bottom end of the column tube, the bottom end of the column tube is inserted into the socket, a bottom plate is arranged at the bottom end of the socket, an inlet is arranged at the upper end of the column tube, and a outlet is arranged at the bottom end of the column tube.

[0006] Preferably, a soft pad is provided at the inner side of the ring, and the soft pad is adhered to the inner side of the ring by adhesive.

[0007] Preferably, a rubber plug is provided at the bottom end of the cover plate, and the rubber plug is adhered to the bottom end of the cover plate by adhesive.

[0008] Preferably, a wrench is provided on one side of the cover plate, and the wrench is welded on one side of the cover plate.

[0009] Preferably, a self-cleaning layer is provided on the outer side of the column tube, and the self-cleaning layer is provided as a nano-silicon coating layer.

[0010] Preferably, a friction pad is provided at the bottom end of the base plate, and the friction pad is adhered to the bottom end of the base plate by adhesive.

[0011] Compared with the prior art, the beneficial effects of the utility model are:

[0012] 1. After adding or during the interval, the column tube can be placed inside the socket so that the column tube can be placed upright, which is very convenient. The setting of the cover can close the column tube when not in use to prevent dust from entering the column tube;

[0013] 2. When installing the cover plate, the rubber plug will be deformed under pressure to fill the gap between the cover plate and the column tube, making the cover plate installed more tightly;

[0014] 3. The setting of the wrench is convenient for the staff to hold, so that it is easy for the staff to turn it, so as to quickly open the cover;

[0015] 4. The nano-silicon coating layer used in the self-cleaning layer has the properties of being hydrophobic and dust-resistant, which can keep the outer surface of the column tube clean for a long time and facilitate the cleaning of the column tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0017] Figure 1 It is a structural schematic diagram of the utility model;

[0018] Figure 2 It is a structural schematic diagram of the column tube of the utility model;

[0019] Figure 3 This is a schematic diagram of the structure of the socket of the utility model;

[0020] Figure 4 This is a schematic diagram of the structure of the cover plate of the utility model;

[0021] Figure 5 It is a schematic diagram of the internal structure of the column tube of the utility model.

[0022] In the figure: 1. column tube; 2. self-cleaning layer; 3. socket; 4. bottom plate; 5. friction pad; 6. rubber plug; 7. collar; 8. inlet; 9. soft pad; 10. soft connector; 11. wrench; 12. outlet; 13. solid phase carrier; 14. cover plate. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] See also Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 In an embodiment of the utility model, a DNA synthesis column comprises a column tube 1; a cover plate 14 is arranged at the upper end of the column tube 1, and the bottom end of the cover plate 14 covers the upper end of the column tube 1; a soft connector 10 is installed at one side of the cover plate 14, a collar 7 is installed at one side of the soft connector 10, and the collar 7 is sleeved at the upper side of the column tube 1; a solid phase carrier 13 is installed inside the column tube 1; a socket 3 is arranged at the bottom end of the column tube 1, and the bottom end of the column tube 1 is inserted into the socket 3; a bottom plate 4 is installed at the bottom end of the socket; an inlet 8 is arranged at the upper end of the column tube 1, and a outlet 12 is arranged at the bottom end of the column tube 1.

[0025] A soft pad 9 is provided inside the collar 7 and is adhered to the inside of the collar 7 by adhesive. The soft pad 9 is provided to increase the friction between the collar 7 and the column tube 1 to avoid the collar 7 from sliding up and down during use.

[0026] A rubber plug 6 is provided at the bottom end of the cover plate 14, and the rubber plug 6 is adhered to the bottom end of the cover plate 14 by adhesive. When the cover plate 14 is installed, the rubber plug 6 will be compressed and deformed to fill the gap between the cover plate 14 and the column tube 1, so that the cover plate 14 is installed more tightly; a wrench 11 is provided at one side of the cover plate 14, and the wrench 11 is welded at one side of the cover plate 14. The setting of the wrench 11 is convenient for the staff to hold, so that it is convenient for the staff to turn it, so as to facilitate the quick opening of the cover plate 14.

[0027] A self-cleaning layer 2 is arranged on the outside of the column tube 1. The self-cleaning layer 2 is arranged as a nano-silicon coating layer. The nano-silicon coating layer used in the self-cleaning layer 2 has the properties of being hydrophobic and dust-resistant to adhere. It can keep the outer surface of the column tube 1 clean for a long time and is convenient for cleaning the column tube 1.

[0028] A friction pad 5 is provided at the bottom end of the bottom plate 4, and the friction pad 5 is adhered to the bottom end of the bottom plate 4 by adhesive. The friction pad 5 is provided to increase the friction force at the bottom end of the bottom plate 4 to avoid the socket 3 from sliding during use.

[0029] Working principle and usage process of the present utility model: When in use, open the cover plate 14, and liquid can be injected into the column tube 1. After the addition is completed or during an intermediate break, the column tube 1 can be placed inside the socket 3 so that the column tube 1 can be placed upright, which is very convenient. The setting of the cover plate 14 can seal the column tube 1 when not in use to prevent dust from entering the column tube 1. When the cover plate 14 needs to be removed, directly separate the collar 7 from the column tube 1.

[0030] Finally, it should be noted that the above are only the preferred embodiments of the present utility model and are not used to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments or perform equivalent replacements for some of the technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A DNA synthesis column, comprising a column tube (1); characterized in that: The upper end of the column tube (1) is provided with a cover plate (14), the lower end of the cover plate (14) covers the upper end of the column tube (1), a soft connector (10) is installed at one side of the cover plate (14), a sleeve ring (7) is installed at one side of the soft connector (10), the sleeve ring (7) is sleeved at the upper side of the column tube (1), a solid phase carrier (13) is installed inside the column tube (1), a socket (3) is provided at the lower end of the column tube (1), the lower end of the column tube (1) is inserted into the socket (3), a bottom plate (4) is installed at the lower end of the socket (3), an inlet (8) is provided at the upper end of the column tube (1), and a outlet (12) is provided at the lower end of the column tube (1).

2. A DNA synthesis column according to claim 1, characterized in that: A soft pad (9) is arranged on the inner side of the sleeve ring (7), and the soft pad (9) is adhered to the inner side of the sleeve ring (7) by adhesive.

3. A DNA synthesis column according to claim 1, characterized in that: A rubber plug (6) is provided at the bottom end of the cover plate (14), and the rubber plug (6) is adhered to the bottom end of the cover plate (14) by adhesive.

4. A DNA synthesis column according to claim 1, characterized in that: A wrench (11) is provided at one side of the cover plate (14), and the wrench (11) is welded at one side of the cover plate (14).

5. A DNA synthesis column according to claim 1, characterized in that: A self-cleaning layer (2) is arranged on the outside of the column tube (1), and the self-cleaning layer (2) is arranged as a nano-silicon coating layer.

6. A DNA synthesis column according to claim 1, characterized in that: A friction pad (5) is provided at the bottom end of the bottom plate (4), and the friction pad (5) is adhered to the bottom end of the bottom plate (4) by adhesive.

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