Temperature heating device

Abstract

The utility model discloses a temperature heating device which comprises a support, a bottom plate, a top plate, first bakelite, second bakelite, a first temperature control body, a first Peltier, a first radiator, a second temperature control body, a second Peltier, a second radiator and a clamping box, and a second matching groove is formed in one side of the bottom plate; the top plate is hinged to the bottom plate, and a first matching groove is formed in the top plate; the first bakelite is arranged in the first matching groove, and a first matching hole is formed in the first bakelite; the second bakelite is arranged in the second matching groove, and a second matching hole is formed in the second bakelite; the first temperature control body is arranged in the first matching hole; the first Peltier is arranged on one side of the first temperature control body; the first radiator is arranged on one side of the first Peltier; the second temperature control body is arranged in the second matching hole; the second Peltier is arranged on one side of the second temperature control body; the second radiator is arranged on one side of the second Peltier. The problem that an existing PCR and hybridization reaction card box is poor in heating effect due to the fact that single-face heating is adopted can be solved.

Description

Technical Field

[0001] The present application relates to the technical field of nucleic acid molecule detection, and in particular to a temperature heating device. Background Art

[0002] PCR (polymerase chain reaction) amplification and other nucleic acid molecule detection technologies are widely used in the detection of medical and other industries, which involves a key supporting technology - high-speed, stable and ultra-efficient temperature increase and decrease control technology to achieve PCR temperature cycle. To achieve efficient temperature control, in addition to high-power circuit software systems, there is another particularly important aspect, which is to match the efficient heating and heat dissipation mechanical structure of the PCR plus hybridization reaction box.

[0003] The existing mechanical structure of the PCR plus hybridization reaction cassette heating is relatively complex, and generally adopts single-sided heating, which has a poor heating effect. Therefore, it is urgent to design a temperature heating device to solve the above problems.

[0004] The above contents are only used to assist in understanding the technical solution of the present application and do not constitute an admission that the above contents are prior art. Utility Model Content

[0005] The main purpose of the present application is to provide a temperature heating device, which aims to solve the problem that the mechanical structure of the existing PCR plus hybridization reaction box heating is relatively complex and the heating effect is poor using single-sided heating.

[0006] To achieve the above-mentioned purpose, the present application provides a temperature heating device, including a bracket, a bottom plate, a top plate, a first bakelite, a second bakelite, a first temperature control body, a first Peltier, a first radiator, a second temperature control body, a second Peltier, a second radiator and a card box, wherein the bottom plate is fixed on the bracket, the middle part of the bottom plate is a hollow structure, and a second matching groove is provided on the side of the bottom plate away from the bracket; the top plate is arranged on the side of the bottom plate away from the bracket and is hinged to the bottom plate, and a first matching groove is provided on the side of the top plate facing the bottom plate; the first bakelite is arranged in the first matching groove, and a through first matching groove is provided on the first bakelite hole; a second bakelite is arranged in the second matching groove, the second bakelite is fitted with the first bakelite, and a through second matching hole is opened on the second bakelite; a first temperature control body is arranged in the first matching hole; a first Peltier is arranged on a side of the first temperature control body away from the bracket; a first radiator is arranged on a side of the first Peltier away from the first temperature control body; a second temperature control body is arranged in the second matching hole; a second Peltier is arranged on a side of the second temperature control body facing the bracket; a second radiator is arranged on a side of the second Peltier away from the second temperature control body; and a card box is arranged between the first bakelite and the second bakelite.

[0007] Optionally, the card box includes a plate body, a plurality of liquid capsules, a plurality of flow channels and a hybridization chamber, wherein the plate body has a heating part and a bearing part, the heating part of the plate body is located between the first temperature control body and the second temperature control body; the plurality of liquid capsules are arranged on the bearing part of the plate body; the plurality of flow channels correspond one-to-one to the plurality of liquid capsules; and the hybridization chamber is connected to each of the liquid capsules through the flow channels.

[0008] Optionally, the first bakelite is also provided with a plurality of liquid bag air pressure holes and a hybridization chamber matching hole, the plurality of liquid bags correspond one to one with the plurality of liquid bag air pressure holes, and each of the liquid bags is matched in the corresponding liquid bag air pressure hole; the hybridization chamber is matched in the hybridization chamber matching hole; the second bakelite is also provided with a plate body groove, and the plate body is matched in the plate body groove.

[0009] Optionally, the temperature heating device further comprises a plurality of hinges and locks, wherein the plurality of hinges are arranged between the bottom plate and the top plate; the locks are arranged between the bottom plate and the top plate and are located on a side opposite to the plurality of hinges.

[0010] Optionally, the lock includes an upper connecting seat, a lower connecting seat, a locking plate, a limiting portion and a locking plate matching portion, wherein the upper connecting seat is fixed to a side of the top plate facing away from the hinge; the lower connecting seat is fixed to a side of the bottom plate facing away from the hinge; the locking plate is connected to the upper connecting seat, and one end of the locking plate close to the lower connecting seat is arranged as a curved structure; the limiting portion is a U-shaped structure and is fixed to the lower connecting seat; the locking plate matching portion is arranged on the limiting portion, and a matching rod is arranged at one end of the locking plate matching portion close to the lock plate, and the matching rod matches with the curved structure of the locking plate.

[0011] Optionally, the bracket includes a stabilizing plate, a plurality of pillars, a first connecting plate and a second connecting plate, wherein the stabilizing plate is in contact with the ground; a plurality of pillars are evenly arranged on the stabilizing plate; the first connecting plate is an L-shaped structure, the first connecting plate includes a vertical section and a horizontal section, the vertical section of the first connecting plate is connected to the bottom plate, and the horizontal section of the first connecting plate is connected to the pillar; the second connecting plate is an L-shaped structure, the second connecting plate includes a vertical section and a horizontal section, the vertical section of the second connecting plate is connected to the bottom plate, and the horizontal section of the second connecting plate is connected to the pillar.

[0012] Optionally, the temperature heating device also includes a vibration mixing motor seat, a vibration mixing motor and a cam, wherein the vibration mixing motor seat is arranged on the horizontal section of the first connecting plate; the vibration mixing motor is fixed on the vibration mixing motor seat; and the cam is arranged at the output end of the vibration mixing motor.

[0013] Optionally, the temperature heating device also includes a first radiator pressure plate and a second radiator pressure plate, wherein the first radiator pressure plate is fitted on the first radiator and fixes the first radiator to the top plate; the second radiator pressure plate is fitted on the second radiator and fixes the second radiator to the bottom plate.

[0014] Optionally, the temperature heating device further comprises an extrusion assembly, wherein the extrusion assembly is arranged on a side of the top plate facing away from the bottom plate.

[0015] Optionally, the extrusion assembly includes two mounting frames, two slide rails, two sliders, two transition plates, a slide rail connecting plate, a second slide rail, a second slider, a motor connecting plate, an extrusion motor and an extrusion rod, wherein the two mounting frames are relatively arranged on the top plate; the two slide rails correspond to the mounting frames, and the two slide rails are respectively connected to the two mounting frames; the two sliders are respectively slidably arranged on the two slide rails; the two transition plates are respectively fixed on the two sliders; the slide rail connecting plate is fixed on the two transition plates; the second slide rail is arranged on the slide rail connecting plate, and the extension direction of the second slide rail is perpendicular to the extension direction of the two slide rails; the second slider is slidably fitted on the second slide rail; the motor connecting plate is fixed on the second slider; the extrusion motor is fixed on the motor connecting plate; and the extrusion rod is arranged at the output end of the extrusion motor.

[0016] A temperature heating device proposed in an embodiment of the present application is provided, by arranging a card box between a first bakelite and a second bakelite, the first bakelite and the second bakelite clamp and fix the card box, and the card box is heated by a first temperature control body and a second temperature control body to achieve temperature regulation. Specifically, the first temperature control body and the second temperature control body can be connected to a power supply and a control device respectively, and the on and off of the power supply and the current size are controlled by the control device, so as to achieve temperature control of the first temperature control body and the second temperature control body. When heating is required, the control device controls the first temperature control body and the second temperature control body to be powered on and heated, and the heat is transferred to the first radiator and the second radiator through the first Peltier and the second Peltier, and is transferred to the card box through the top plate and the bottom plate, so as to achieve heating of the card box. At the same time, the setting of the first radiator and the second radiator can effectively dissipate heat and improve the heat dissipation efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic diagram of the three-dimensional structure of a temperature heating device provided in an embodiment of the present application;

[0018] Figure 2 for Figure 1 A structural diagram from another perspective;

[0019] Figure 3 for Figure 2A schematic diagram of a three-dimensional structure without the first radiator and the second radiator;

[0020] Figure 4 for Figure 3 A magnified schematic diagram of part A;

[0021] Figure 5 for Figure 3 Schematic diagram of the three-dimensional structure from another perspective;

[0022] Figure 6 An exploded diagram showing the positional relationship between bakelite, a temperature control body and a Peltier in a temperature heating device involved in the present application;

[0023] Figure 7 An exploded view of the positional relationship between the first bakelite, the second bakelite and the card box in the temperature heating device involved in the present application;

[0024] Figure 8 for Figure 1 Schematic diagram of the structure of the middle top plate;

[0025] Fig. 9 for Figure 1 Schematic diagram of the structure of the midsole plate.

[0026] Among them, 1, bracket; 101, stabilizing plate; 102, pillar; 103, first connecting plate; 104, second connecting plate; 2, bottom plate; 201, second matching groove; 3, top plate; 301, first matching groove; 4, first bakelite; 401, first matching hole; 402, liquid capsule air pressure hole; 403, hybridization chamber matching hole; 5, second bakelite; 501, second matching hole; 502, plate body groove; 6, first temperature control body; 7, first Peltier; 8, first radiator; 9, second temperature control body; 10, second Peltier; 11, second radiator; 12, cartridge; 1201, plate body; 1202, liquid capsule; 1203, flow channel; 1204, Hybridization chamber; 13. hinge; 14. lock; 1401. upper connecting seat; 1402. lower connecting seat; 1403. lock plate; 1404. limit part; 1405. lock plate matching part; 1406. matching rod; 15. vibration mixing motor seat; 16. vibration mixing motor; 17. first radiator pressure plate; 18. second radiator pressure plate; 19. extrusion assembly; 1901. mounting frame; 1902. slide rail; 1903. slider; 1904. transition plate; 1905. slide rail connecting plate; 1906. second slide rail; 1907. second slider; 1908. motor connecting plate; 1909. extrusion motor; 1910. extrusion rod.

[0027] The realization of the purpose, functional features and advantages of this application will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0029] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back...) are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0030] In the present invention, unless otherwise clearly specified and limited, the terms "connection", "fixation", etc. should be understood in a broad sense. For example, "fixation" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0031] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the utility model, the descriptions of "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the meaning of "and / or" appearing in the full text includes three parallel schemes. Taking "A and / or B" as an example, it includes scheme A, or scheme B, or a scheme that satisfies both A and B. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the ability of ordinary technicians in this field to implement. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the utility model.

[0032] See also Figures 1 to 9The embodiment of the present application provides a temperature heating device, which may include a bracket 1, a bottom plate 2, a top plate 3, a first bakelite 4, a second bakelite 5, a first temperature control body 6, a first Peltier 7, a first radiator 8, a second temperature control body 9, a second Peltier 10, a second radiator 11 and a card box 12, wherein the bottom plate 2 is fixed on the bracket 1, the middle part of the bottom plate 2 is a hollow structure, and a second matching groove 201 is provided on the side of the bottom plate 2 away from the bracket 1; the top plate 3 is arranged on the side of the bottom plate 2 away from the bracket 1, and is hinged to the bottom plate 2, and a first matching groove 301 is provided on the side of the top plate 3 facing the bottom plate 2; the first bakelite 4 is arranged in the first matching groove 301, and a A through first matching hole 401; the second bakelite 5 is arranged in the second matching groove 201, the second bakelite 5 is fitted with the first bakelite 4, and the second bakelite 5 is provided with a through second matching hole 501; the first temperature control body 6 is arranged in the first matching hole 401; the first Peltier 7 is arranged on the side of the first temperature control body 6 away from the bracket 1; the first heat sink 8 is arranged on the side of the first Peltier 7 away from the first temperature control body 6; the second temperature control body 9 is arranged in the second matching hole 501; the second Peltier 10 is arranged on the side of the second temperature control body 9 facing the bracket 1; the second heat sink 11 is arranged on the side of the second Peltier 10 away from the second temperature control body 9; the card box 12 is arranged between the first bakelite 4 and the second bakelite 5.

[0033] When the temperature heating device involved in the present application is used, the card box 12 is set between the first bakelite 4 and the second bakelite 5, the first bakelite 4 and the second bakelite 5 clamp and fix the card box 12, and the card box 12 is heated by the first temperature control body 6 and the second temperature control body 9 to achieve temperature regulation. Specifically, the first temperature control body 6 and the second temperature control body 9 can be connected to the power supply and the control device respectively, and the power supply and the current are controlled by the control device, so as to achieve temperature control of the first temperature control body 6 and the second temperature control body 9. When heating is required, the control device controls the first temperature control body 6 and the second temperature control body 9 to be powered on and heated, and the heat is transferred to the first radiator 8 and the second radiator 11 through the first Peltier 7 and the second Peltier 10, and is transferred to the card box 12 through the top plate 3 and the bottom plate 2, so as to achieve heating of the card box 12. At the same time, the setting of the first radiator 8 and the second radiator 11 can effectively dissipate heat and improve the heat dissipation efficiency.

[0034] See also Figure 7 The card box 12 may include a plate body 1201, multiple liquid capsules 1202, multiple flow channels 1203 and a hybridization chamber 1204, wherein the plate body 1201 has a heating part and a bearing part, the heating part of the plate body 1201 is located between the first temperature control body 6 and the second temperature control body 9; the multiple liquid capsules 1202 are arranged on the bearing part of the plate body 1201; the multiple flow channels 1203 correspond to the multiple liquid capsules 1202 one by one; the hybridization chamber 1204 is connected to each liquid capsule 1202 through the flow channel 1203.

[0035] The heating part of the plate body 1201 is located between the first temperature control body 6 and the second temperature control body 9, which can ensure that the heating part of the cartridge 12 is heated evenly and efficiently. A plurality of liquid capsules 1202 are arranged on the bearing part of the plate body 1201, and these liquid capsules 1202 can contain and heat various liquid samples, such as PCR reagents. Each liquid capsule 1202 is connected to the hybridization chamber 1204 through a corresponding flow channel 1203, so that the liquid sample can be easily flowed into the hybridization chamber 1204 after heating for subsequent hybridization reaction.

[0036] In addition, the arrangement of the liquid capsule 1202 and the flow channel 1203 not only makes the heating and flow of the liquid sample more convenient, but also effectively avoids cross contamination between samples, thereby improving the accuracy and reliability of the experiment. As the core part of the cartridge 12, the hybridization chamber 1204 can provide a stable and temperature-controlled environment, so that the hybridization reaction can proceed smoothly.

[0037] It is worth noting that the material of the cartridge 12 should be high temperature resistant, corrosion resistant, and easy to clean to ensure its stability and durability during use. At the same time, the design of the liquid capsule 1202 and the flow channel 1203 should also take into account the convenience of operations such as adding, removing, and cleaning samples to improve experimental efficiency.

[0038] In practical applications, the card box 12 can be used in conjunction with a temperature heating device to achieve precise temperature control of the liquid sample in the card box 12 by adjusting the temperatures of the first temperature control body 6 and the second temperature control body 9 .

[0039] See also Figure 7 The first bakelite 4 is also provided with a plurality of liquid bag air pressure holes 402 and a hybridization chamber matching hole 403, the plurality of liquid bags 1202 correspond one to one with the plurality of liquid bag air pressure holes 402, and each liquid bag 1202 is matched in the corresponding liquid bag air pressure hole 402; the hybridization chamber 1204 is matched in the hybridization chamber matching hole 403; the second bakelite 5 is also provided with a plate body groove 502, and the plate body 1201 is matched in the plate body groove 502.

[0040] In this embodiment, by providing multiple liquid capsule air pressure holes 402 and a hybridization chamber matching hole 403 on the first bakelite 4, multiple liquid capsules 1202 are exposed from the first bakelite 4, which facilitates squeezing of the multiple liquid capsules 1202 so that the liquid flows into the hybridization chamber 1204 along the flow channel 1203.

[0041] See also Figure 1 to Figure 3 The temperature heating device may further include a plurality of hinges 13 and locks 14 , wherein the plurality of hinges 13 are disposed between the bottom plate 2 and the top plate 3 ; the locks 14 are disposed between the bottom plate 2 and the top plate 3 and are located on a side opposite to the plurality of hinges 13 .

[0042] Among them, the hinged connection between the bottom plate 2 and the top plate 3 is realized by multiple hinges 13, the structure is simple and reliable, and the top plate 3 can be separated from the bottom plate 2 to facilitate taking out or putting in the card box 12; by arranging a lock 14 between the bottom plate 2 and the top plate 3, the bottom plate 2 and the top plate 3 can be made to fit more compactly, and the hybridization reaction will not be affected by the poor fit between the bottom plate 2 and the top plate 3.

[0043] See also Figure 4 The lock buckle 14 may include an upper connecting seat 1401, a lower connecting seat 1402, a locking plate 1403, a limiting portion 1404 and a locking plate matching portion 1405, wherein the upper connecting seat 1401 is fixed to the side of the top plate 3 away from the hinge 13; the lower connecting seat 1402 is fixed to the side of the bottom plate 2 away from the hinge 13; the locking plate 1403 is connected to the upper connecting seat 1401, and one end of the locking plate 1403 close to the lower connecting seat 1402 is set to a curved structure; the limiting portion 1404 is a U-shaped structure and is fixed to the lower connecting seat 1402; the locking plate matching portion 1405 is set on the limiting portion 1404, and one end of the locking plate matching portion 1405 close to the lock plate 1403 is set with a matching rod 1406, and the matching rod 1406 matches with the curved structure of the locking plate 1403.

[0044] It should be noted that when the lock 14 is actually used, the lock plate 1403 is moved downward to disengage the curved structure of the lock plate 1403 from the matching rod 1406, and then the top plate 3 can be rotated relative to the bottom plate 2 to open, so as to facilitate the insertion or removal of the cartridge 12. When the top plate 3 and the bottom plate 2 need to be locked, the top plate 3 only needs to be covered on the bottom plate 2, and the curved structure of the lock plate 1403 is buckled on the matching rod 1406 to complete the locking operation. This locking method is simple and easy to operate, and the locking is firm and reliable, which can effectively prevent the top plate 3 and the bottom plate 2 from being accidentally opened during the hybridization reaction.

[0045] See also Figure 2 The bracket 1 may include a stabilizing plate 101, a plurality of pillars 102, a first connecting plate 103 and a second connecting plate 104, wherein the stabilizing plate 101 is in contact with the ground; a plurality of pillars 102 are evenly arranged on the stabilizing plate 101; the first connecting plate 103 is an L-shaped structure, the first connecting plate 103 includes a vertical section and a horizontal section, the vertical section of the first connecting plate 103 is connected to the bottom plate 2, and the horizontal section of the first connecting plate 103 is connected to the pillar 102; the second connecting plate 104 is an L-shaped structure, the second connecting plate 104 includes a vertical section and a horizontal section, the vertical section of the second connecting plate 104 is connected to the bottom plate 2, and the horizontal section of the second connecting plate 104 is connected to the pillar 102.

[0046] Among them, the bracket 1 is the main structure of the temperature heating device, and its design not only has stability, but also takes into account the convenience of operation. In this embodiment, the bracket 1 adopts a combination design of a stabilizing plate 101, a plurality of pillars 102, a first connecting plate 103 and a second connecting plate 104, so that the entire device is more stable and easy to assemble and disassemble. The stabilizing plate 101 fits the ground to ensure the stability of the bracket 1. A plurality of pillars 102 are evenly arranged on the stabilizing plate 101, providing sufficient support force to prevent the device from shaking or tilting during use. The first connecting plate 103 and the second connecting plate 104 are both designed with an L-shaped structure, which not only makes the connection more firm, but also facilitates connection with the bottom plate 2 and the pillar 102. The vertical sections of the first connecting plate 103 and the second connecting plate 104 are respectively connected to the bottom plate 2, and the horizontal sections are connected to the pillar 102, forming a stable support structure, which further enhances the stability of the bracket 1.

[0047] See also Figure 2 The temperature heating device may further include a vibration mixing motor seat 15, a vibration mixing motor 16 and a cam, wherein the vibration mixing motor seat 15 is arranged on the horizontal section of the first connecting plate 103; the vibration mixing motor 16 is fixed on the vibration mixing motor seat 15; and the cam is arranged at the output end of the vibration mixing motor 16.

[0048] In this embodiment, by arranging a vibration mixing motor seat 15, a vibration mixing motor 16 and a cam on the temperature heating device, automatic mixing of the liquid sample in the cartridge 12 can be achieved, thereby improving the uniformity and efficiency of the hybridization reaction. The vibration mixing motor seat 15 is a component for supporting and fixing the vibration mixing motor 16, and is arranged on the horizontal section of the first connecting plate 103, so as to be conveniently connected and fixed to the bracket 1. The vibration mixing motor 16 is fixed on the vibration mixing motor seat 15, and the vibration mixing operation of the liquid sample in the cartridge 12 can be achieved by controlling the start and stop of the vibration mixing motor 16. The cam is arranged at the output end of the vibration mixing motor 16. When the vibration mixing motor 16 is started, the vibration can be transmitted to the cartridge 12 through the rotation of the cam, so that the liquid sample in the cartridge 12 vibrates, thereby achieving a mixing effect.

[0049] The temperature heating device provided in this embodiment realizes accurate temperature control and automatic mixing of the liquid sample in the cartridge 12 by adopting a stable and reliable support structure, a convenient and fast lock design, and an efficient and uniform vibration mixing mechanism, thereby improving the efficiency and accuracy of the hybridization reaction. At the same time, the temperature heating device also has the advantages of simple structure, convenient operation, safety and reliability, and is suitable for various biological experiment scenarios requiring hybridization reactions.

[0050] See also Figure 1 , Figure 2The temperature heating device may further include a first radiator pressing plate 17 and a second radiator pressing plate 18, wherein the first radiator pressing plate 17 is matched with the first radiator 8 and fixes the first radiator 8 to the top plate 3; the second radiator pressing plate 18 is matched with the second radiator 11 and fixes the second radiator 11 to the bottom plate 2.

[0051] By setting the first radiator pressing plate 17 and the second radiator pressing plate 18, it can be ensured that the first radiator 8 and the second radiator 11 are stably fixed on the top plate 3 and the bottom plate 2 respectively, so as to achieve effective heat dissipation. This design not only improves the heat dissipation efficiency, but also prevents the experimental results from being affected by excessive temperature during the hybridization reaction. At the same time, the installation of the first radiator pressing plate 17 and the second radiator pressing plate 18 is also relatively simple, which is convenient for users to assemble and maintain.

[0052] In actual use, the user only needs to align the first heat sink pressing plate 17 and the second heat sink pressing plate 18 with the positions of the first heat sink 8 and the second heat sink 11 respectively and fix them. In this way, when the temperature heating device is working, the first heat sink 8 and the second heat sink 11 can effectively dissipate the generated heat, maintain the stability of the temperature inside the temperature heating device, and thus ensure the smooth progress of the hybridization reaction.

[0053] See also Figure 1 , Figure 2 The temperature heating device may further include an extrusion component 19 , wherein the extrusion component 19 is disposed on a side of the top plate 3 facing away from the bottom plate 2 .

[0054] Among them, the arrangement of the squeezing component 19 enables the temperature heating device to squeeze the liquid capsule 1202 through the squeezing component 19 when it is closed, thereby further promoting the mixing effect of the liquid sample in the cartridge 12. When the top plate 3 is covered on the bottom plate 2, the squeezing component 19 will contact the liquid capsule 1202 and apply a certain pressure to it, so that the liquid sample in the liquid capsule 1202 flows and mixes under pressure. This squeezing and mixing method can effectively improve the mixing degree of the liquid sample, making the hybridization reaction more uniform and efficient. At the same time, the design of the squeezing component 19 can be adjusted as needed to adapt to liquid capsules 1202 of different specifications and capacities, thereby increasing the flexibility and applicability of the temperature heating device.

[0055] See also Figure 5The extrusion assembly 19 may include two mounting frames 1901, two slide rails 1902, two sliders 1903, two transition plates 1904, a slide rail connecting plate 1905, a second slide rail 1906, a second slider 1907, a motor connecting plate 1908, an extrusion motor 1909 and an extrusion rod 1910, wherein the two mounting frames 1901 are relatively arranged on the top plate 3; the two slide rails 1902 correspond to the mounting frames 1901, and the two slide rails 1902 are respectively connected to the two mounting frames 1901; the two sliders 1903 are respectively slidably arranged on the two slide rails 190 2; two transition plates 1904 are respectively fixed on the two sliders 1903; the slide rail connecting plate 1905 is fixed on the two transition plates 1904; the second slide rail 1906 is arranged on the slide rail connecting plate 1905, and the extension direction of the second slide rail 1906 is perpendicular to the extension direction of the two slide rails 1902; the second slider 1907 is slidably matched on the second slide rail 1906; the motor connecting plate 1908 is fixed on the second slider 1907; the extrusion motor 1909 is fixed on the motor connecting plate 1908; the extrusion rod 1910 is arranged at the output end of the extrusion motor 1909.

[0056] In actual application, when the top plate 3 is covered on the bottom plate 2, the squeezing assembly 19 will start. The squeezing motor 1909 drives the squeezing rod 1910 to reciprocate, and the squeezing rod 1910 is moved on a two-dimensional plane by the sliding of the second slider 1907 on the second slide rail 1906 and the sliding of the two sliders 1903 on the two slide rails 1902. In this way, the squeezing rod 1910 can squeeze the liquid capsule 1202 in all directions to ensure that the liquid sample is fully mixed. At the same time, since the structural design of the squeezing assembly 19 is reasonable and precise control can be achieved, excessive pressure or damage to the liquid capsule 1202 can be avoided. In addition, the user can also adjust the rotation speed of the squeezing motor 1909 and the moving range of the squeezing rod 1910 according to actual needs to meet different experimental requirements.

[0057] Through the above design, the temperature heating device not only has a stable support structure and efficient heat dissipation performance, but also realizes the automatic mixing operation of liquid samples. This temperature heating device has a wide range of application prospects in the field of biological experiments, especially in experimental scenarios where hybridization reactions are required, which can significantly improve experimental efficiency and accuracy.

[0058] The above are only preferred embodiments of the present application, and are not intended to limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A temperature heating device, characterized in that: include: Bracket (1); A bottom plate (2) is fixed on the bracket (1); the middle portion of the bottom plate (2) is a hollow structure; a second matching groove (201) is provided on a side of the bottom plate (2) facing away from the bracket (1); A top plate (3) is arranged on a side of the bottom plate (2) facing away from the bracket (1) and is hinged to the bottom plate (2); a first matching groove (301) is arranged on a side of the top plate (3) facing the bottom plate (2); A first bakelite (4) is arranged in the first matching groove (301), and the first bakelite (4) is provided with a through first matching hole (401) in the thickness direction thereof; A second bakelite (5) is arranged in the second matching groove (201), the second bakelite (5) is fitted with the first bakelite (4), and the second bakelite (5) is provided with a through second matching hole (501) in the thickness direction thereof; A first temperature control body (6) is arranged in the first matching hole (401); A first Peltier (7) is arranged on a side of the first temperature control body (6) facing away from the bracket (1); A first heat sink (8) is arranged on a side of the first Peltier (7) facing away from the first temperature control body (6); A second temperature control body (9) is arranged in the second matching hole (501); A second Peltier (10) is arranged on a side of the second temperature control body (9) facing the bracket (1); A second heat sink (11) is arranged on a side of the second Peltier (10) facing away from the second temperature control body (9); The card box (12) is arranged between the first bakelite (4) and the second bakelite (5).

2. The temperature heating device according to claim 1, characterized in that: The card box (12) comprises: A plate body (1201) having a heating portion and a bearing portion, wherein the heating portion of the plate body (1201) is located between the first temperature control body (6) and the second temperature control body (9); A plurality of liquid capsules (1202) are arranged on the bearing portion of the plate body (1201); A plurality of flow channels (1203), corresponding one-to-one to the plurality of liquid capsules (1202); The hybridization chamber (1204) is connected to each of the liquid capsules (1202) through the flow channel (1203).

3. The temperature heating device according to claim 2, characterized in that: The first bakelite (4) is also provided with a plurality of liquid capsule air pressure holes (402) and a hybridization chamber matching hole (403), the plurality of liquid capsules (1202) correspond to the plurality of liquid capsule air pressure holes (402) one by one, and each of the liquid capsules (1202) is matched in the corresponding liquid capsule air pressure hole (402); the hybridization chamber (1204) is matched in the hybridization chamber matching hole (403); The second bakelite (5) is also provided with a plate body groove (502), and the plate body (1201) is fitted into the plate body groove (502).

4. The temperature heating device according to claim 1, characterized in that: The temperature heating device also includes: A plurality of hinges (13) are arranged between the bottom plate (2) and the top plate (3); A lock buckle (14) is arranged between the bottom plate (2) and the top plate (3) and is located on a side opposite to the plurality of hinges (13).

5. The temperature heating device according to claim 4, characterized in that: The lock buckle (14) comprises: An upper connecting seat (1401) is fixed to a side of the top plate (3) facing away from the hinge (13); A lower connecting seat (1402) is fixed to a side of the bottom plate (2) facing away from the hinge (13); A locking plate (1403) is connected to the upper connecting seat (1401), and one end of the locking plate (1403) close to the lower connecting seat (1402) is configured as a curved structure; The limiting portion (1404) is a U-shaped structure and is fixed on the lower connecting seat (1402); The lock plate matching portion (1405) is arranged on the limiting portion (1404), and a matching rod (1406) is arranged at one end of the lock plate matching portion (1405) close to the lock plate (1403), and the matching rod (1406) matches with the curved structure of the lock plate (1403).

6. The temperature heating device according to claim 1, characterized in that: The support (1) comprises: A stabilizing plate (101) is in contact with the ground; A plurality of pillars (102) are evenly arranged on the stabilizing plate (101); The first connecting plate (103) is an L-shaped structure, the first connecting plate (103) comprises a vertical section and a horizontal section, the vertical section of the first connecting plate (103) is connected to the bottom plate (2), and the horizontal section of the first connecting plate (103) is connected to the support (102); The second connecting plate (104) is an L-shaped structure. The second connecting plate (104) includes a vertical section and a horizontal section. The vertical section of the second connecting plate (104) is connected to the bottom plate (2), and the horizontal section of the second connecting plate (104) is connected to the support (102).

7. The temperature heating device according to claim 6, characterized in that: The temperature heating device also includes: A vibration mixing motor base (15) is arranged on the horizontal section of the first connecting plate (103); A vibration mixing motor (16) fixed on the vibration mixing motor base (15); A cam is arranged at the output end of the vibration mixing motor (16).

8. The temperature heating device according to claim 1, characterized in that: The temperature heating device also includes: A first radiator pressing plate (17) is matched with the first radiator (8) and fixes the first radiator (8) to the top plate (3); The second radiator pressing plate (18) is matched with the second radiator (11) and fixes the second radiator (11) to the bottom plate (2).

9. The temperature heating device according to claim 1, characterized in that: The temperature heating device also includes: An extrusion assembly (19) is arranged on a side of the top plate (3) facing away from the bottom plate (2).

10. The temperature heating device according to claim 9, characterized in that: The extrusion assembly (19) comprises: Two mounting frames (1901) are arranged opposite to each other on the top plate (3); Two slide rails (1902), corresponding to the mounting frame (1901), the two slide rails (1902) are respectively connected to the two mounting frames (1901); Two sliding blocks (1903) are respectively slidably disposed on the two sliding rails (1902); Two transition plates (1904) are respectively fixed on the two sliding blocks (1903); A slide rail connecting plate (1905) fixed on the two transition plates (1904); A second slide rail (1906) is arranged on the slide rail connecting plate (1905), and the extension direction of the second slide rail (1906) is perpendicular to the extension direction of the two slide rails (1902); A second sliding block (1907) slidably engaged with the second sliding rail (1906); A motor connecting plate (1908) fixed on the second sliding block (1907); An extrusion motor (1909) is fixed on the motor connecting plate (1908); The extrusion rod (1910) is arranged at the output end of the extrusion motor (1909).

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