Quantitative uniform mixing device for drug-loaded microspheres

Abstract

The utility model provides a quantitative uniform mixing device for drug-loaded microspheres. The quantitative uniform mixing device comprises a uniform mixing tank, a discharge valve, a sterile rotating device, a feeding device and a counting device, a feeding hole is formed in a tank cover of the uniform mixing tank and is connected with a feeding device; a discharge valve is arranged at the bottom of the uniform mixing tank; and a sterile rotating device and a counting device are respectively arranged on the side wall of the tank body. The feeding port is formed in the tank cover of the uniform mixing tank and connected with the feeding device, microspheres and auxiliary materials are added into the uniform mixing tank through the feeding device and the feeding port at different adding time, the leakage risk caused by manual operation of workers is avoided, in addition, the sterile rotating device and the counting device are further arranged, and the safety of the workers is improved. The mixing tank body and the mixing tank body are matched with each other to realize uniform mixing of microspheres and auxiliary materials, and a discharge valve is further arranged at the bottom of the mixing tank body, so that accurate discharge can be realized. Compared with traditional manual mixing, the quantitative uniform mixing device for the drug-loaded microspheres is easy to operate, the labor cost is reduced, and the conversion efficiency of finished products is improved.

Description

Technical Field

[0001] The utility model relates to the field of biomedical pharmaceutical devices, in particular to a drug-loaded microsphere quantitative mixing device. Background Art

[0002] In the process of microsphere preparation, the stage from the autoclave to the handball is currently mainly completed by manual operation. Workers need to wear isolation gloves and flip the microspheres in the cavity to make the microspheres and excipients evenly mixed. However, due to the limitation of the internal space of the isolator, manual operation is not only inconvenient, but also may lead to uneven mixing. In addition, when adding necessary excipients before mixing, it is impossible to accurately quantify the excipients. After mixing, the discharging process also requires manual flipping to pour the materials into the freeze-drying tray for the next freeze-drying treatment. Manual operation is not only inefficient, but also difficult to operate. Summary of the Utility Model

[0003] The purpose of the utility model is to provide a drug-loaded microsphere quantitative mixing device, which realizes synchronous feeding of microspheres and excipients, avoids the leakage risk caused by manual feeding of personnel, makes the microspheres and excipients evenly mixed, and improves the finished product conversion efficiency.

[0004] The utility model provides a drug-loaded microsphere quantitative mixing device, which comprises: a mixing tank, a discharging valve, a sterile rotating device, a feeding device and a counting device;

[0005] The tank cover of the mixing tank is provided with a feeding port, and the feeding port is connected with the feeding device;

[0006] The discharging valve is arranged at the bottom of the mixing tank;

[0007] The sterile rotating device and the counting device are respectively arranged on the side wall of the tank body of the mixing tank.

[0008] Furthermore, it further comprises: a height adjusting rod and a height adjusting handwheel;

[0009] The height adjusting handwheel is arranged on one side of the height adjusting rod;

[0010] The height adjusting rod is fixed to the sterile rotating device.

[0011] Furthermore, it further comprises a balance adjusting part, a mounting bracket and a rectangular base;

[0012] Mounting brackets are respectively and obliquely fixed on both sides of the height adjusting rod, and the bottoms of multiple mounting brackets are respectively fixed at the four top corners of the rectangular base;

[0013] The balance adjusting part is arranged at the bottom of the rectangular base.

[0014] Further, the balance adjusting member is a leveling foot;

[0015] The leveling feet are respectively arranged at the four top corners of the rectangular base.

[0016] Further, it further includes: an exhaust nozzle, and the exhaust nozzle is arranged on the lid of the mixing tank body.

[0017] Further, the feeding device includes a feeding valve and a sterile feeding pipeline;

[0018] The feeding valve is arranged on the sterile feeding pipeline;

[0019] One end of the sterile feeding pipeline is connected to the feeding port, and the other end is connected to a feeding control device.

[0020] Further, the feeding device further includes a PID proportional control valve and a front-end switching valve;

[0021] The PID proportional control valve and the front-end switching valve are respectively arranged on the sterile feeding pipeline.

[0022] Further, the sterile rotating device includes a sterile rotating bearing, a sterile rotating shaft and a crank;

[0023] The sterile rotating shaft is connected to the crank through a flange, and the sterile rotating bearing is sleeved outside the sterile rotating shaft.

[0024] Further, the counting device includes: a counter and a counter fixing bracket;

[0025] The counter fixing bracket is fixed on the side wall of the mixing tank body;

[0026] The counter is installed on the counter fixing bracket.

[0027] Further, the drug-loaded microsphere quantitative mixing device is arranged in the cavity of the sterile isolator.

[0028] Compared with the prior art, the present utility model has at least the following technical effects:

[0029] By arranging a feeding port on the lid of the mixing tank in the present utility model, the feeding port is connected to the feeding device, and microspheres and excipients are respectively added into the mixing tank through the feeding device and the feeding port at different adding times, avoiding the leakage risk caused by manual operation of personnel. In addition, the present utility model is also provided with a sterile rotating device and a counting device, which cooperate with each other to realize the uniform mixing of microspheres and excipients. A discharging valve is also arranged at the bottom of the mixing tank body, which can realize accurate discharging. Compared with the traditional manual mixing, the use of the above-mentioned drug-loaded microsphere quantitative mixing device is easy to operate, reduces the labor cost, and improves the finished product conversion efficiency. Description of the Drawings

[0030] Figure 1 Structural schematic of the drug-loaded microsphere quantitative mixing device in an embodiment of the present utility model Figure 1 ;

[0031] Figure 2 Structural schematic of the drug-loaded microsphere quantitative mixing device in an embodiment of the present utility model Figure 2 。 Detailed Embodiments

[0032] The following will describe a drug-loaded microsphere quantitative mixing device of the present utility model in conjunction with the schematic diagrams, in which the preferred embodiments of the present utility model are shown. It should be understood that those skilled in the art can modify the present utility model described herein while still achieving the advantageous effects of the present utility model. Therefore, the following description should be understood as a broad guidance for those skilled in the art and not as a limitation to the present utility model.

[0033] The present utility model will be described more specifically by way of example with reference to the attached drawings in the following paragraphs. The advantages and features of the present utility model will be clearer according to the following description. It should be noted that the attached drawings are all in a very simplified form and use non-precise scales, only for conveniently and clearly assisting in explaining the purpose of the embodiments of the present utility model.

[0034] This embodiment provides a drug-loaded microsphere quantitative mixing device, including: a mixing tank 2, a discharging valve 13, a sterile rotating device, a feeding device, and a counting device.

[0035] The mixing tank 2 is provided with a feeding port on its tank cover, and the feeding port is connected to the feeding device; the discharging valve 13 is provided at the bottom of the mixing tank 2; the sterile rotating device and the counting device are respectively provided at the side wall of the tank body of the mixing tank 2.

[0036] In this embodiment, by providing a feeding port on the tank cover of the mixing tank 2, and the feeding port is connected to the feeding device, the microspheres and excipients are respectively added into the mixing tank 2 through the feeding device and the feeding port at different adding times, avoiding the leakage risk caused by manual operation. In addition, the present utility model is also provided with a sterile rotating device and a counting device, which cooperate with each other to achieve the uniform mixing of the microspheres and excipients. A discharging valve 13 is also provided at the bottom of the mixing tank body, which can achieve accurate discharging. Compared with the traditional manual mixing, using the above-mentioned drug-loaded microsphere quantitative mixing device is easy to operate, reduces the labor cost, and improves the finished product conversion efficiency.

[0037] Those skilled in the art can understand that the above-mentioned drug-loaded microsphere quantitative mixing device is not limited to the microsphere production line, but can also be other types of pharmaceutical production lines.

[0038] In this embodiment, the feeding device includes a feeding valve and a sterile feeding pipeline.

[0039] Specifically, the feeding valve is arranged on the sterile feeding pipeline; one end of the sterile feeding pipeline is connected to the feeding port, and the other end is connected to the feeding control device.

[0040] More specifically, a PID proportional control valve and a front-end switching valve are also arranged on the sterile feeding pipeline.

[0041] The PID proportional control valve is used to control the flow rate of the microspheres. After sieving, the wet microspheres enter the mixing tank 2 through the sterile feeding pipeline. At this time, the feeding valve is opened to control the microspheres in the sterile feeding pipeline to enter the mixing tank 2 at a certain rate. When the PID proportional control valve is closed, the microspheres no longer enter the mixing tank 2. The exhaust nozzle 12 on the tank cover of the mixing tank 2 is opened to prevent the internal pressure of the tank from being too high. At this time, the front-end switching valve is opened to control the auxiliary materials to enter the mixing tank 2.

[0042] In a specific example, the feeding valve 1 can be a metering feeding valve 1 to further control the microspheres and auxiliary materials added to the mixing tank 2.

[0043] In a specific example, the feeding pipeline is a sterile feeding hose; a sterile environment needs to be maintained between the feeding valve and the sterile feeding pipeline; one end of the sterile feeding hose connected to the feeding port also needs to be kept sealed so that the microspheres and auxiliary materials are in a sterile environment, preventing external contaminants from entering and improving the finished product conversion efficiency.

[0044] Furthermore, the sterile rotating device includes a sterile rotating bearing 11 and a crank 3.

[0045] Specifically, the crank 3 is welded to the side wall of the mixing tank body; the sterile rotating shaft is connected to the crank 3 through a flange, and the sterile rotating bearing 11 is sleeved outside the sterile rotating shaft.

[0046] After the microspheres and auxiliary materials are filled, the discharge valve 13 and the exhaust nozzle are closed. The relevant operators wear sterile isolator gloves and rotate the crank 3 to repeatedly turn and shake the microspheres and auxiliary materials in the mixing tank 2 through the sterile flange bearing. Compared with manual shaking, the above shaking method is more time-saving and labor-saving.

[0047] In a specific example, the handle of the crank 3 is set in a petal shape and is designed with anti-slip to facilitate grasping. Those skilled in the art can select the specific shape of the handle of the crank 3 according to actual needs.

[0048] In order to monitor the mixing process, ensure sufficient mixing time, enable the materials to fully contact and be evenly mixed, a counting device is also provided at the side wall of the mixing tank body in this embodiment to count the number of turns the crank 3 rotates. The counting device includes: a counter 5 and a counter fixing bracket 4.

[0049] Specifically, the counter fixing bracket 4 is fixed on the side wall of the mixing tank body; the counter 5 is installed on the counter fixing bracket 4.

[0050] In a specific example, the counter fixing bracket 4 is welded to the side wall of the mixing tank body, and there is a hole inside the fixing bracket. The counter 5 passes through the hole. The counter 5 can be fixed to the fixing bracket by welding or other means, or the counter 5 can be placed in the hole for convenient replacement later.

[0051] Before the mixing operation, according to the process requirements, the number of turns required to be rotated when the mixture is uniform can be preset in the counter 5 in advance. Rotate the crank 3, and the counter 5 counts the number of turns the crank 3 rotates. When the number of turns the crank 3 rotates reaches the preset value, open the discharge valve 13 provided at the bottom of the mixing tank 2. The discharge valve 13 can more accurately control the discharge speed and discharge amount, so that the product is evenly and equally distributed into the freeze-drying trays for subsequent processing.

[0052] Furthermore, in order to maintain the stability of the equipment and the convenience of operation, and enable the feed inlet on the lid of the mixing tank 2 to be connected to the drug-loaded microsphere quantitative mixing device through a sterile feed pipeline, the device further includes a height adjustment rod 10, a height adjustment handwheel 6, a balance adjustment member, a mounting bracket 9, and a rectangular base.

[0053] The height adjustment handwheel 6 is fixed to one side of the height adjustment rod 10 through an adjustment nut 7; the height adjustment rod 10 is fixed to the sterile rotation device.

[0054] In this embodiment, by rotating the height adjustment handwheel 6, the height adjustment rod 10 can be adjusted to expand and contract vertically through the adjustment nut 7, thereby realizing the height adjustment of the mixing tank 2.

[0055] Mounting brackets 9 are respectively and obliquely fixed to both sides of the height adjustment rod 10. The bottoms of multiple mounting brackets 9 are respectively fixed at the four top corners of the rectangular base, and the balance adjustment member is arranged at the bottom of the rectangular base.

[0056] During the specific operation process, adjust the four leveling feet 8 to make the rectangular base parallel to the ground, so that the mixing tank 2 is also in a horizontal position. Then rotate the height adjustment handwheel 6, and the height adjustment rod 10 can be contracted up and down, thereby adjusting the position height of the mixing tank 2.

[0057] In this embodiment, the mixing tank 2 is placed inside the inner cavity of the aseptic isolator, which is a device used in high-cleanliness requirement fields such as biopharmaceuticals, microbial culture, and cell culture. It can provide a sterile environment to prevent the microspheres and excipients from being contaminated by external microorganisms.

[0058] Obviously, those skilled in the art can make various changes and modifications to the present utility model without departing from the spirit and scope of the present utility model. Thus, if these modifications and variations of the present utility model fall within the scope of the claims of the present utility model and its equivalent technologies, the present utility model is also intended to include these changes and modifications.

Claims

1. A quantitative mixing device for drug-loaded microspheres, characterized in that: include: Mixing tank, discharge valve, sterile rotating device, feeding device and counting device; The tank cover of the mixing tank is provided with a feed port, and the feed port is connected to the feed device; The bottom of the mixing tank is provided with the discharge valve; The aseptic rotating device and the counting device are respectively arranged on the side walls of the tank body of the mixing tank.

2. The drug-loaded microsphere quantitative mixing device according to claim 1, characterized in that: Also includes: Height adjustment lever and height adjustment hand wheel; The height adjustment hand wheel is arranged on one side of the height adjustment rod; The height adjustment rod is fixed to the sterile rotating device.

3. The quantitative mixing device for drug-loaded microspheres according to claim 2, characterized in that: Also included are a balance adjuster, mounting bracket, and rectangular base; A mounting bracket is respectively fixed obliquely on both sides of the height adjustment rod, and the bottoms of the plurality of mounting brackets are respectively fixed at the four top corners of the rectangular base; The balance adjustment member is arranged at the bottom of the rectangular base.

4. The drug-loaded microsphere quantitative mixing device according to claim 3, characterized in that: The balance adjustment member is a leveling foot; The leveling feet are respectively arranged at the four top corners of the rectangular base.

5. The quantitative mixing device for drug-loaded microspheres according to claim 1, characterized in that: Also includes: An exhaust nozzle is arranged on the tank cover of the mixing tank.

6. The drug-loaded microsphere quantitative mixing device according to claim 1, characterized in that: The feeding device comprises a feeding valve and a sterile feeding pipeline; The feeding valve is arranged on the sterile feeding pipeline; One end of the sterile feeding pipeline is connected to the feeding port, and the other end is connected to the feeding control device.

7. The quantitative mixing device for drug-loaded microspheres according to claim 6, characterized in that: The feeding device also includes a PID proportional control valve and a front-end switching valve; The PID proportional control valve and the front-end switching valve are respectively arranged on the sterile feeding pipeline.

8. The drug-loaded microsphere quantitative mixing device according to claim 1, characterized in that: The sterile rotating device comprises a sterile rotating bearing, a sterile rotating shaft and a crank; The sterile rotating shaft is connected to the crank handle via a flange, and the sterile rotating bearing is sleeved outside the sterile rotating shaft; The crank handle is welded to the side wall of the mixing tank body.

9. The drug-loaded microsphere quantitative mixing device according to claim 1, characterized in that: The counting device comprises: a counter and a counter fixing frame; The counter fixing frame is fixed on the side wall of the mixing tank body; The counter is mounted on the counter fixing frame.

10. The drug-loaded microsphere quantitative mixing device according to claim 1, characterized in that: The drug-loaded microsphere quantitative mixing device is arranged in the cavity of the sterile isolator.

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