Multi-purpose bioreactor aeration disc

Abstract

The utility model belongs to the technical field of biological stirring, and particularly discloses a multipurpose aeration disc of a bioreactor. The multi-purpose bioreactor aeration disc is of an annular structure, the inner annular surface of the aeration disc is used for penetrating through a shaft part and abutting against a second bearing, the aeration disc is provided with a first annular inner cavity and a second annular inner cavity which are mutually independent, the outer side wall of the first annular inner cavity is provided with a plurality of first aeration holes, and the outer side wall of the second annular inner cavity is provided with a plurality of second aeration holes. A plurality of second aeration holes are formed in the outer side wall of the second annular inner cavity, the first annular inner cavity is provided with a first air port, and the second annular inner cavity is provided with a second air port. The inner cavity and the outer cavity of the multi-purpose bioreactor aeration disc are both connected with the air source which can release clean air, the multi-purpose bioreactor aeration disc is located in the container when being integrally installed, the air supply pipe of the multi-purpose bioreactor aeration disc can also be arranged in the container, and the pipe body is connected with the multi-purpose bioreactor aeration disc from top to bottom.

Description

Technical Field

[0001] The utility model belongs to the technical field of biological stirring, and particularly relates to an aeration disk of a multi-purpose bioreactor. Background Art

[0002] Disposable bag-type bioreactors are widely used in the biochemical field, and a magnetic stirrer for a disposable bag-type bioreactor is a key device that is matched with the disposable bag-type bioreactor.

[0003] Most of the existing stirring mechanisms need to fix both ends of the stirring shaft, but this requires relatively high installation conditions for the container. The existing disposable bottom multi-layer stirrers generally need to fix both ends of the stirring shaft to ensure the stability of operation. This structure requires the top end of the stirring shaft to be fixed above the stirring bag, the stirring shaft needs to be relatively long, there are many parts in the stirring bag, and the precision requirements for the supporting container are also relatively high. At present, most aeration disks are components independent of the stirrer, with low integration, resulting in many parts in the stirring bag and a complex structure. Summary of the Utility Model

[0004] In order to solve the above problems, the utility model provides the following solutions:

[0005] The aeration disk of the multi-purpose bioreactor is of an annular structure, and its inner ring surface is used for passing through the shaft part and abutting against the second bearing. The aeration disk has

[0006] Mutually independent first annular inner cavity and second annular inner cavity. The outer side wall of the first annular inner cavity has a plurality of first air holes, the outer side wall of the second annular inner cavity has a plurality of second air holes, the first annular inner cavity has a first air port, and the second annular inner cavity has a second air port.

[0007] In some modes, the inner ring surface of the aeration disk has an inner ring limiting convex part, and the inner diameter of the inner ring limiting convex part is smaller than the outer diameter of the second bearing that abuts against it.

[0008] In some modes, the aeration disk has fixing holes penetrating through the disk body.

[0009] In some modes, the outer expansion elastic part of the welding disk passes through the fixing hole of the aeration disk and locks the aeration disk on the welding disk. At this time, the inner ring limiting convex part axially locks the second bearing in the second concave part at the end of the shaft sleeve.

[0010] In some modes, the inner diameter of the first air hole is smaller than that of the second air hole.

[0011] In some modes, the chamber volume of the first annular inner cavity is larger than that of the second annular inner cavity.

[0012] In some modes, the aeration disk includes a first flap and a second flap that are buckled with each other.

[0013] In some ways, the first air port runs through the second annular inner cavity horizontally.

[0014] In the multi-purpose bioreactor aeration disc of the present disclosure, both the inner and outer cavities are connected to an air source to release clean air. And since the multi-purpose bioreactor aeration disc is installed inside a container as a whole, its air supply pipe can also be arranged inside the container, and the pipe body is connected to the multi-purpose bioreactor aeration disc from top to bottom. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a three-dimensional view of the assembled state of the multi-purpose bioreactor aeration disc;

[0016] Figure 2 It is a sectional view of the assembled state of the multi-purpose bioreactor aeration disc;

[0017] Figure 3 、 4 It is an exploded view of the shaft part;

[0018] Figure 5 It is a three-dimensional view of the assembled state of the shaft part;

[0019] Figure 6 It is a sectional view of the aeration disc;

[0020] Figure 7 It is a connection state diagram of the shaft sleeve and the shaft body;

[0021] Figures 8 - 9 It is an assembly state diagram of the stirrer;

[0022] Figure 10 It is a diagram of the flow direction of bubbles and liquid after the aeration disc discharges air.

[0023] In the figure:

[0024] 100 Shaft part, 110 Shaft body, 120 Mounting seat, 121 Welding disc, 122 Moving component, 123 Second bearing, 124 First bearing, 125 Connecting clip, 126 Outer expanding elastic member, 200 Aeration disc, 210 First annular inner cavity, 211 First aeration hole, 212 First air port, 220 Second annular inner cavity, 221 Second aeration hole, 222 Second air port, 310 Driving component, 320 Flexible bag. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] The following further describes the present utility model with reference to the accompanying drawings.

[0026] The multi-purpose bioreactor aeration disc, as Figure 1 shown in, includes

[0027] a shaft part 100, having

[0028] Mounting base 120, the middle of its welding pad 121 is concaved to form a mounting cavity for placing one end of the shaft body 110, and the bottom of the mounting cavity is used to set the first bearing 124.

[0029] Shaft body 110, one end located in the mounting cavity has a responsive component 122 and the end of this end is sleeved with the first bearing 124. The shaft body 110 is also sleeved with a second bearing 123. The second bearing 123 is located outside the mounting cavity and is pressed and locked by the aeration disc 200. And

[0030] Aeration disc 200, which is of an annular structure. Its inner ring surface is used to abut against the second bearing 123. The aeration disc 200 has: mutually independent first annular inner cavity 210 and second annular inner cavity 220. The outer side wall of the first annular inner cavity 210 has a plurality of first air holes 211, and the outer side wall of the second annular inner cavity 220 has a plurality of second air holes 221. The first annular inner cavity 210 has a first air port 212, and the second annular inner cavity 220 has a second air port 222. The aeration disc 200 also has a fixing hole penetrating the disc body for passing through and connecting the clamping member 125.

[0031] As Figure 2 shown in, one end of the shaft body 110 is a shaft sleeve. The two ends of the shaft sleeve respectively have a first concave part and a second concave part. The first concave part is used to sleeve the first bearing 124, and the second concave part is used to sleeve the second bearing 123. And, there is a limiting convex part between the first concave part and the second concave part for restricting the first bearing 124 and the second bearing 123 from approaching, that is, by pressing the first bearing 124 and the second bearing 123 in the limiting convex part, the positioning of the first bearing 124 and the second bearing 123 is realized, and at the same time, the positioning of the shaft sleeve is also realized. By setting the first bearing 124 and the second bearing 123 for positioning at one end, it can be realized that the shaft can be fixed only by limiting at one end of the shaft body, so that the other end of the shaft part 100 does not need to be fixed to keep the shaft part in a working state well, reducing the requirements for the installation environment.

[0032] As Figure 7 shown in, the shaft body 110 and the shaft sleeve can be detachably connected. For example, a sleeve opening is provided at the end of the shaft sleeve, and then a fixing hole is opened on the side wall. Fixing holes are also provided on the side wall of the connecting end of the shaft body 110. The connecting end of the shaft body 110 is inserted into the sleeve opening of the shaft sleeve, and the fixing holes of the two are aligned. Finally, the locking pin 127 penetrates the fixing holes of the two to realize the limiting and locking of the two.

[0033] As Figure 3 、 4As shown in the figure, the inner ring surface of the aeration disc 200 has an inner ring limiting protrusion, and the inner ring limiting protrusion abuts against the upper end of the second bearing 123. The specific abutting manner between the limiting parts and the bearings is not particularly limited, as long as the normal rotation of the bearings can be maintained.

[0034] As Figures 1 - 3 shown in the figure, the welding disc 121 further has a connecting clip 125. The end of the connecting clip 125 has an outwardly expanding elastic member 126. After the outwardly expanding elastic member 126 passes through the fixing hole of the aeration disc 200, the aeration disc 200 is locked to the welding disc 121. At this time, the inner ring limiting protrusion axially locks the second bearing 123 to the second concave portion, that is, to prevent the second bearing 123 from moving along the shaft body. The welding disc 121 is generally located at the bottom of the reaction vessel. Thus, when the aeration disc 200 is installed, it is also located at the bottom of the vessel. At this time, the pipe body for supplying gas to the aeration disc 200 can be arranged from bottom to top, reducing the risk of air leakage. And the end of the gas supply pipe far from the aeration disc 200 is arranged at a higher position (especially above the liquid level in the vessel), so it is not easy to have backflow. Especially due to the existence of air pressure, even if liquid enters the aeration disc 200 and flows back into the gas supply pipe, because the air inlet position of the pipe body is higher, the liquid is not easy to flow out from the gas supply pipe.

[0035] As Figure 2 、 4 shown in the figure, when the outwardly expanding elastic member 126 locks the aeration disc 200, the shaft sleeve is locked between the second bearing 123 and the first bearing 124.

[0036] As Figure 5 shown in the figure, the other end of the shaft sleeve far from the moving component 122 is used to set the rotating shaft.

[0037] In practical applications, the outer edge of the welding disc 121 is used to connect the installation opening of the flexible bag 320, and it can also be combined with other containers. The specific situation is not strictly limited. The moving component 122 is a magnet, and it can rotate under the drive of the driving component 310, thereby driving the shaft part 100 to rotate for stirring operation.

[0038] As Figure 10 shown in the figure, the air holes are used to introduce clean air to provide oxygen for the cells in the stirring bag. At the same time, two kinds of air hole diameters are set to facilitate improving the uniformity of the dissolved oxygen of the liquid in various parts of the stirring bag. (The smaller and denser the bubbles are, the larger the relative contact area with the liquid is, and the dissolution oxygen rate can be increased. The floating rates of bubbles of different sizes are different. By setting different pore diameters, the bubble density difference in various parts of the stirring bag can be avoided). The inner diameter of the first air hole 211 is smaller than that of the second air hole 221; the chamber volume of the first annular inner cavity 210 is larger than that of the second annular inner cavity 220. The aeration disc 200 includes a first flap 201 and a second flap 202 that are buckled with each other. As Figure 6It is divided into two petals up and down. Among them, the first air port 212, which is the same as the first annular inner cavity 210, passes through the tube body from the second annular inner cavity 220. Its main purpose is to realize the ventilation of the first air port 212 and the second air port 222 on the premise of keeping the first annular inner cavity 210 and the second annular inner cavity 220 independent of each other.

[0039] Those skilled in the art can clearly understand that various modifications to the above embodiments can be made without departing from the overall spirit and concept of the present utility model. All of them fall within the protection scope of the present utility model. The protection scheme of the present utility model shall be subject to the claims attached to the present utility model.

Claims

1. Multi-purpose bioreactor aeration tray, characterized in that: It is an annular structure, the inner annular surface of which is used to pass through the shaft portion (100) and abut against the second bearing (123). The aeration plate (200) has A first annular inner cavity (210) and a second annular inner cavity (220) are independent of each other, the outer wall of the first annular inner cavity (210) has a plurality of first aeration holes (211), the outer wall of the second annular inner cavity (220) has a plurality of second aeration holes (221), the first annular inner cavity (210) has a first air port (212), and the second annular inner cavity (220) has a second air port (222).

2. The multi-purpose bioreactor aeration tray according to claim 1, characterized in that: The inner ring surface of the aeration disc (200) has an inner ring limiting convex portion, and the inner diameter of the inner ring limiting convex portion is smaller than the outer diameter of the second bearing (123) abutting against the inner ring limiting convex portion.

3. The multi-purpose bioreactor aeration tray according to claim 2, characterized in that: The aeration plate (200) has a fixing hole penetrating the plate body.

4. The multi-purpose bioreactor aeration tray according to claim 3, characterized in that: The outwardly expanded elastic member (126) of the welding disk (121) passes through the fixing hole of the aeration disk (200) to lock the aeration disk (200) on the welding disk (121), and at this time, the inner ring limiting protrusion axially locks the second bearing (123) on the second inner recess at the end of the sleeve.

5. The multi-purpose bioreactor aeration tray according to claim 1, characterized in that: The inner diameter of the first aeration hole (211) is smaller than that of the second aeration hole (221).

6. The multi-purpose bioreactor aeration tray according to claim 1, characterized in that: The chamber volume of the first annular inner chamber (210) is greater than the chamber volume of the second annular inner chamber (220).

7. The multi-purpose bioreactor aeration tray according to claim 1, characterized in that: The aeration plate (200) comprises a first petal (201) and a second petal (202) which are interlocked.

8. The multi-purpose bioreactor aeration tray according to claim 1, characterized in that: The first air port (212) transversely penetrates the second annular inner cavity (220).

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