Three-dimensional electrostatic spinning receiving device

Abstract

The utility model relates to a three-dimensional electrostatic spinning receiving device which comprises a hemispherical stainless steel shell, a needle rod assembly, a base, a connecting rod, a fixing bolt and a motor. The base is connected with the connecting rod, the connecting rod is connected with the fixing bolt, the motor is connected to one side of the fixing bolt, the hemispherical stainless steel shell is rotationally connected to the other side of the fixing bolt, and the output end of the motor penetrates through the fixing bolt to be connected with the outer wall of the hemispherical stainless steel shell. The needle rod assembly is arranged on the inner wall of the hemispherical stainless steel shell, and an opening of the hemispherical stainless steel shell is right opposite to the spinneret opening. The three-dimensional electrostatic spinning receiving device provided by the utility model aims to overcome the existing defects, is matched with conventional electrostatic spinning equipment for use, is simple and convenient to mount, and can be used for efficiently preparing a three-dimensional fiber bracket with a stable structure.

Description

Technical Field

[0001] The utility model relates to a three-dimensional electrospinning receiving device. Background Art

[0002] Electrospinning refers to the process of diverging polymer droplets into fibers under the action of a strong electric field and finally accumulating to form a fiber scaffold. The macroscopic structure of the electrospun scaffold mainly depends on the receiving device. Currently, the receiving devices are mainly flat plates or rollers, on which the electric field distribution is uniform, resulting in the fibers being tightly stacked layer by layer, and finally obtaining a two-dimensional film-like material with a dense structure and a low porosity. However, tissue engineering scaffolds such as skin scaffolds need to have a three-dimensional porous structure, which can not only play a filling role but also promote tissue infiltration. Moreover, the curvature of the fibers is beneficial to the adhesion and migration of specific cells, and the pore structure formed by the fiber accumulation is relatively stable. Therefore, the three-dimensional fiber scaffold has broad application prospects in the field of tissue engineering.

[0003] For the preparation of three-dimensional fiber scaffolds, one method is to extend the spinning time to increase the thickness of the fiber membrane, or perform post-treatment on the fiber membrane, such as salting out and foaming. Another method is to design a new type of electrospinning device, adjust the structural dimensions of the spinneret, and build multiple syringes to prepare porous three-dimensional fiber scaffolds. However, although extending the spinning time does increase the thickness of the fiber membrane, the fiber stacking is still tight, and the subsequent treatment is time-consuming and laborious. Designing a new spinning device greatly increases the cost.

[0004] Therefore, a three-dimensional electrospinning receiving device is proposed to solve the above problems. Content of the Utility Model

[0005] The purpose of the utility model is to provide a three-dimensional electrospinning receiving device to overcome the existing defects. When used in conjunction with a conventional electrospinning device, it is easy to install and can efficiently prepare a three-dimensional fiber scaffold with a stable structure.

[0006] The technical solution to achieve the above purpose is: a three-dimensional electrospinning receiving device, including a hemispherical stainless-steel shell, a needle rod assembly, a base, a connecting rod, a fixing bolt, and a motor; the connecting rod is connected to the base, the fixing bolt is connected to the connecting rod, the motor is connected to one side of the fixing bolt, the hemispherical stainless-steel shell is rotatably connected to the other side of the fixing bolt, the output end of the motor passes through the fixing bolt and is connected to the outer wall of the hemispherical stainless-steel shell, the needle rod assembly is arranged on the inner wall of the hemispherical stainless-steel shell, and the opening of the hemispherical stainless-steel shell faces the spinneret.

[0007] Preferably, the needle rod assembly includes a plurality of first stainless steel needles and an insulating layer. The insulating layer is disposed inside the hemispherical stainless steel housing. The plurality of first stainless steel needles are evenly arranged on the insulating layer, and the bottoms of the plurality of first stainless steel needles are in contact with the inner wall of the hemispherical stainless steel housing. The hemispherical stainless steel housing is electrically connected to the negative electrode of the electrospinning machine.

[0008] Preferably, the needle rod assembly includes a plurality of second stainless steel needles and a conductive wire. The plurality of second stainless steel needles are evenly arranged on the hemispherical stainless steel housing and penetrate through the hemispherical stainless steel housing. The ends of the plurality of second stainless steel needles located on the outer side wall of the hemispherical stainless steel housing are connected by the conductive wire, and the other end of the conductive wire is electrically connected to the negative electrode of the electrospinning machine.

[0009] Preferably, the insulating layer is made of polypropylene.

[0010] Preferably, the lengths of the plurality of first stainless steel needles are different, and they gradually become shorter in the direction close to the spinneret.

[0011] Preferably, the lengths of the plurality of second stainless steel needles are different, and they gradually become shorter in the direction close to the spinneret.

[0012] The beneficial effects of the present utility model are as follows: In this three-dimensional electrospinning receiving device, by providing a hemispherical stainless steel housing, a needle rod assembly, a base, a connecting rod, a fixing bolt, and a motor; the base is connected to the connecting rod, the connecting rod is connected to the fixing bolt, the motor is connected to one side of the fixing bolt, the hemispherical stainless steel housing is rotatably connected to the other side of the fixing bolt, the output end of the motor penetrates through the fixing bolt and is connected to the outer wall of the hemispherical stainless steel housing, the needle rod assembly is disposed on the inner wall of the hemispherical stainless steel housing, and the opening of the hemispherical stainless steel housing faces the spinneret. Starting from the perspective of the electrospinning receiving device, a device specifically designed for the preparation of three-dimensional fiber scaffolds is designed, which can be used in conjunction with conventional electrospinning equipment, is easy to install, and can efficiently prepare three-dimensional fiber scaffolds with stable structures. Description of the Drawings

[0013] Figure 1 is a schematic diagram of the first embodiment of the three-dimensional electrospinning receiving device of the present utility model;

[0014] Figure 2 is a schematic diagram of the second embodiment of the three-dimensional electrospinning receiving device of the present utility model.

[0015] In the figure: 2, hemispherical stainless steel housing; 3, insulating layer; 4, first stainless steel needle; 5, base; 6, connecting rod; 7, fixing bolt; 8, motor; 9, spinneret; 10, second stainless steel needle; 11, conductive wire. Detailed Embodiments

[0016] The technical solution of the present utility model will be clearly and completely described below in conjunction with the accompanying drawings. In the description of the present utility model, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0017] The present utility model will be further described below in conjunction with the accompanying drawings.

[0018] Embodiment 1

[0019] As Figure 1 shown, the three-dimensional electrospinning receiving device includes a hemispherical stainless steel shell 2, a needle rod assembly, a base 5, a connecting rod 6, a fixing bolt 7 and a motor 8; the connecting rod 6 is connected to the base 5, the fixing bolt 7 is connected to the connecting rod 6, the motor 8 is connected to one side of the fixing bolt 7, the hemispherical stainless steel shell 2 is rotatably connected to the other side of the fixing bolt 7, the output end of the motor 8 penetrates through the fixing bolt 7 and is connected to the outer wall of the hemispherical stainless steel shell 2, the needle rod assembly is arranged on the inner wall of the hemispherical stainless steel shell 2, and the opening of the hemispherical stainless steel shell 2 faces the spinneret 9. The hemispherical stainless steel shell 2 is simultaneously connected to the motor 8 and can rotate around the axis at a certain speed under the control of the motor 8.

[0020] Specifically, the diameter of the hemispherical stainless steel shell 2 is 100-200 mm.

[0021] Specifically, the needle rod assembly includes a plurality of first stainless steel needles 4 and an insulating layer 3. The insulating layer 3 is arranged inside the hemispherical stainless steel shell 2. The plurality of first stainless steel needles 4 are evenly arranged on the insulating layer 3, and the bottoms of the plurality of first stainless steel needles 4 are in contact with the inner wall of the hemispherical stainless steel shell 2; the hemispherical stainless steel shell 2 is electrically connected to the negative electrode of the electrospinning machine. The distance between the plurality of first stainless steel needles 4 is 10-30 mm. The length of the stainless steel needles is 2-20 mm, and the lengths of the stainless steel needles at different positions are different, and gradually become shorter towards the direction close to the spinneret.

[0022] Specifically, the insulating layer 3 is made of polypropylene.

[0023] Specifically, the lengths of the plurality of first stainless steel needles 4 are different, and gradually become shorter towards the direction close to the spinneret 9.

[0024] Specifically, the receiving component is a hollow hemisphere, on which the first stainless steel needles 4 are arranged. This design enables the fibers emitted from the positive electrode to accumulate into a three-dimensional scaffold in the three-dimensional space formed by the hemispherical stainless steel shell 2.

[0025] During use, first install the three-dimensional electrospinning receiving device to ensure that the center of the receiving component is directly opposite the spinneret 9. Then install the first stainless steel needles 4. The special arrangement of the first stainless steel needles 4 allows the fibers emitted from the spinneret 9 to gradually accumulate from the bottom of the receiving component and finally form a three-dimensional fiber scaffold similar to a cotton ball. After installing the receiving device, a three-dimensional loose and structurally stable fiber scaffold can be prepared according to the conventional electrospinning procedure.

[0026] The process of preparing the three-dimensional fiber scaffold is as follows: First, install the three-dimensional electrospinning receiving device to ensure that the center of the receiving component is directly opposite the spinneret 9. Then install the first stainless steel needles 4. The spacing of the first stainless steel needles 4 is 20 mm, and the length of the first stainless steel needle 4 farthest from the spinneret is 15 mm. Towards the direction closer to the spinneret, the length of the stainless steel needles decreases by 2 mm in turn. Subsequently, connect the motor 8 to the power supply and connect the hemispherical stainless steel shell 2 to the negative electrode of the electrospinning machine. Finally, prepare the three-dimensional fiber scaffold according to the conventional electrospinning procedure.

[0027] Example 2

[0028] As Figure 1 shown, the needle rod assembly includes multiple second stainless steel needles 10 and conductive wires 11. The multiple second stainless steel needles 10 are evenly arranged on the hemispherical stainless steel shell 2 and penetrate through the hemispherical stainless steel shell 2. The ends of the multiple second stainless steel needles 10 located on the outer side wall of the hemispherical stainless steel shell 2 are connected by the conductive wires 11, and the other end of the conductive wire 11 is electrically connected to the negative electrode of the electrospinning machine. The multiple second stainless steel needles 10 are of different lengths and gradually become shorter in the direction closer to the spinneret 9.

[0029] Specifically, the process of preparing the three-dimensional fiber scaffold is as follows: First, install the three-dimensional electrospinning receiving device to ensure that the center of the receiving component is directly opposite the spinneret 9. Then install the second stainless steel needles 10. The spacing of the second stainless steel needles 10 is 20 mm, and the length of the second stainless steel needle 10 farthest from the spinneret is 15 mm. Towards the direction closer to the spinneret, the length of the stainless steel needles decreases by 2 mm in turn. Subsequently, connect the motor 8 to the power supply and connect one end of the conductive wire 11 to the ends of the multiple second stainless steel needles 10, and the terminal is connected to the negative electrode of the electrospinning machine. Finally, prepare the three-dimensional fiber scaffold according to the conventional electrospinning procedure.

[0030] Specifically, the three-dimensional fiber scaffold prepared by the three-dimensional electrospinning receiving device has a loose three-dimensional structure. After being placed on a plane for 24 hours, no deformation distinguishable by the naked eye occurred. The porosity and pore size distribution of the scaffold were tested, and the porosity was 86%, and the average pore size was 126 μm. If ultimately used for tissue repair, the stable three-dimensional structure of the scaffold enables it to play a filling role, and the high porosity and macroporous structure can promote tissue infiltration, and it is expected to be used as a tissue engineering scaffold.

[0031] This three-dimensional electrospinning receiving device, starting from the perspective of the electrospinning receiving device, designs a device specifically for the preparation of three-dimensional fiber scaffolds. It can be used in conjunction with conventional electrospinning equipment, is easy to install, and can efficiently prepare three-dimensional fiber scaffolds with stable structures.

[0032] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A three-dimensional electrospinning receiving device, characterized in that: The invention comprises a hemispherical stainless steel shell (2), a needle bar assembly, a base (5), a connecting rod (6), a fixing bolt (7) and a motor (8); the base (5) is connected to the connecting rod (6), the connecting rod (6) is connected to the fixing bolt (7), the motor (8) is connected to one side of the fixing bolt (7), the hemispherical stainless steel shell (2) is rotatably connected to the other side of the fixing bolt (7), the output end of the motor (8) passes through the fixing bolt (7) and is connected to the outer wall of the hemispherical stainless steel shell (2), the needle bar assembly is arranged on the inner wall of the hemispherical stainless steel shell (2), and the opening of the hemispherical stainless steel shell (2) is directly opposite to the spinneret (9).

2. The three-dimensional electrospinning receiving device according to claim 1, characterized in that: The needle bar assembly comprises a plurality of first stainless steel needles (4) and an insulating layer (3); the insulating layer (3) is arranged inside the hemispherical stainless steel shell (2); the plurality of first stainless steel needles (4) are evenly arranged on the insulating layer (3), and the bottoms of the plurality of first stainless steel needles (4) are in contact with the inner wall of the hemispherical stainless steel shell (2); the hemispherical stainless steel shell (2) is electrically connected to the negative electrode of the electrospinning machine.

3. The three-dimensional electrospinning receiving device according to claim 1, characterized in that: The needle bar assembly comprises a plurality of second stainless steel needles (10) and a conductive wire (11); the plurality of second stainless steel needles (10) are evenly arranged on a hemispherical stainless steel shell (2) and penetrate the hemispherical stainless steel shell (2); the ends of the plurality of second stainless steel needles (10) located on the outer wall of the hemispherical stainless steel shell (2) are connected via the conductive wire (11); and the other end of the conductive wire (11) is electrically connected to a negative electrode of an electrospinning machine.

4. The three-dimensional electrospinning receiving device according to claim 2, characterized in that: The insulating layer (3) is made of polypropylene.

5. The three-dimensional electrospinning receiving device according to claim 2, characterized in that: The plurality of first stainless steel needles (4) are of different lengths, and gradually become shorter towards the spinneret (9).

6. The three-dimensional electrospinning receiving device according to claim 3, characterized in that: The plurality of second stainless steel needles (10) are of different lengths, and gradually become shorter towards the spinneret (9).

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