Reagent collector

Abstract

The utility model provides a reagent collector. The reagent collector comprises a bracket; the rotary collecting table comprises a driving part arranged at the bottom of the bracket and a reagent disc arranged at the output end of the driving part and positioned above the driving part; the sample injector is arranged above the rotary collection table and comprises a sample injection needle, a first sensor, a sample injection part for fixing the sample injection needle and the first sensor, and a sliding part which drives the sample injection part to move up and down and is mounted above the bracket; wherein the reagent disc is provided with a plurality of clamping grooves which are uniformly distributed in the circumferential direction, reagent bottles are placed in the clamping grooves, and the sample injection needles enter and exit from the reagent bottles to collect reagents; the first sensor comprises a transmitting sensor and a receiving sensor which are respectively fixed on two sides which are spatially isolated from the sample injection needle, are positioned on the same vertical section and are used for detecting the height of a reagent in the reagent bottle. According to the technical scheme, a full-automatic operation technology is adopted, and the problems of inaccurate sampling amount and low working efficiency are effectively solved.

Description

Technical Field

[0001] This application relates to the field of reagent collection, and specifically to a reagent collector. Background Art

[0002] A microreactor is a micro-pipeline reactor based on continuous flow, used to replace traditional reactors. Because it uses a small amount of reagent in use and has high data requirements, more precise technical operations are required in reagent collection.

[0003] The existing reagent collection devices have fixed structures and single performances, unable to meet automation and precision, resulting in inaccurate sampling amounts and inaccurate sample test values, low work efficiency, and poor equipment flexibility. Therefore, there is an urgent need for a new type of reagent collector to meet market development. Utility Model Content

[0004] To solve the above-mentioned technical problems, this application provides a reagent collector, which adopts a fully automatic operation technology and effectively solves the problems of inaccurate sampling amount and low work efficiency.

[0005] This application provides a reagent collector, including: a bracket; a rotary collection table, including a driving part arranged at the bottom of the bracket and a reagent tray arranged at the output end of the driving part and above the driving part; a sampler arranged above the rotary collection table, including a sampling needle, a first sensor, a sampling part for fixing the sampling needle and the first sensor, and a sliding part for driving the sampling part to move up and down and installed above the bracket; wherein, the reagent tray is provided with a plurality of card slots evenly distributed along the circumferential direction, reagent bottles are placed in the card slots, and the sampling needle enters and exits the reagent bottles to collect reagents; the first sensor includes a transmitting sensor and a receiving sensor, which are respectively fixed on two sides spatially isolated from the sampling needle and in the same vertical section to detect the height of the reagent in the reagent bottle.

[0006] Furthermore, the driving part, the sliding part and the first sensor are electrically connected to a controller, and the controller receives the data of the first sensor and controls the start and stop of the driving part and the sliding part.

[0007] Furthermore, the driving part includes a first motor, a synchronous belt, a synchronous belt pulley and a rotating rod. Among them, the first motor is fixed at the bottom of the bracket; the synchronous belt is installed between the output end of the first motor and the synchronous belt pulley; one end of the rotating rod is fixedly installed at the center of the circle of the synchronous belt pulley, and the other end is fixedly installed at the center of the bottom of the reagent tray. As the synchronous belt rotates, it drives the sliding of the reagent tray; the controller controls the start and stop of the first motor.

[0008] Further, the driving part is also provided with a positioning assistor, which is installed on the rotating rod to assist the start and stop of the rotating rod. Among them, the positioning assistor includes a positioning piece fixedly installed in the middle of the rotating rod and a positioning switch that cooperates with the positioning piece to control the positioning piece to stop rotating; the controller is communicatively connected to the positioning switch to control the closing and opening of the positioning switch.

[0009] Further, a waste liquid tray coaxial with the reagent tray is also provided at the bottom of the reagent tray to collect the waste liquid overflowing from the reagent bottle.

[0010] Further, the sliding part includes a second motor, a slider installed at the output end of the second motor, a linear slide rail that cooperates with the slider, and a mounting base plate on which the linear slide rail is installed. Among them, the mounting base plate is fixedly installed on the bracket; the linear slide rail is arranged along the movement direction of the sampling needle; one side of the slider is fixedly installed with a sampling part; the controller controls the start of the second motor.

[0011] Further, the sliding part is also provided with a positioning arm fixed at the end of the linear slide rail and a second sensor communicatively connected to the controller. Among them, the positioning arm is provided with a first through hole for the sampling needle to enter and exit; the second sensor is fixed to the positioning arm and located outside the first through hole, and is in the same vertical section as the sampling needle to determine the position of the reagent bottle.

[0012] Further, the sampling part includes a support plate, a fixing part installed on the support plate, and extension arms provided at both ends of the support plate. Among them, the support plate is arranged perpendicular to the movement direction of the sampling part, one end is fixedly connected to the slider and is provided with a second through hole; the fixing part is a hollow tube that cooperates with the second through hole to position the sampling needle; the end of the extension arm is fixed to the support plate and is perpendicular to the support plate.

[0013] Further, the emission sensor and the reception sensor are respectively fixed at the other end of the extension arm and are in the same vertical section as the sampling needle.

[0014] The technical solution of the present application realizes the automation of the equipment through the control of the controller, realizes the precise control of the sampling volume with the sensitive detection of the sensor, and cooperates with the design of the reagent tray to realize the collection of a large number of samples at one time, improves the work efficiency, reduces the replacement error of the reagent bottle, and improves the equipment utilization rate.

[0015] It should be understood that the content described in the application content part is not intended to limit the key or important features of the embodiments of the present application, nor is it used to limit the scope of the present application. Other features of the present application will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Combined with the drawings and referring to the following detailed description, the above and other features, advantages and aspects of the embodiments of the present application will become more obvious. In the drawings, the same or similar reference numerals represent the same or similar elements, where:

[0017] Figure 1 is the front view of the structure of the reagent collector of this embodiment;

[0018] Figure 2 is the structural diagram of the sampler of the reagent collector of this embodiment;

[0019] Figure 3 is the detection schematic diagram of the first sensor of the reagent collector of this embodiment;

[0020] Among them, Figures 1-3 the corresponding relationship between the reference numerals and the component names in

[0021] 100 Rotating collection table, 110 Reagent bottle, 120 Reagent tray, 130 First motor, 140 Synchronous belt, 150 Synchronous belt pulley, 160 Rotating rod, 170 Positioning piece, 180 Positioning switch, 190 Waste liquid tray;

[0022] 200 Sampler, 210 Sampling needle, 220 Second motor, 230 Slide block, 240 Linear slide rail, 250 Installation base plate, 260 Second sensor, 270 Support plate, 271 Extension arm, 280 Fixing part, 290 First sensor;

[0023] 300 Bracket. Detailed implementation manners

[0024] To make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are some, but not all, of the embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present application without creative efforts shall fall within the protection scope of the present application.

[0025] In addition, the term "and / or" in this article is only a relationship describing associated objects, indicating that three relationships may exist. For example, A and / or B may represent: A exists alone, A and B exist simultaneously, and B exists alone. In addition, the character " / " in this article generally represents an "or" relationship between the associated objects before and after.

[0026] Next, refer to Figure 1A reagent collector provided by the present application is described as follows, including: a bracket 300; a rotary collection table 100, including a driving part arranged at the bottom of the bracket 300 and a reagent tray 120 arranged at the output end of the driving part and above the driving part; a sampler 200, arranged above the rotary collection table 100, including a sampling needle 210, a first sensor 290, a sampling part for fixing the sampling needle 210 and the first sensor 290, and a sliding part for driving the sampling part to move up and down and installed above the bracket; wherein, the reagent tray 120 is provided with a plurality of card slots evenly distributed along the circumferential direction, reagent bottles 110 are placed in the card slots, and the sampling needle 210 enters and exits the reagent bottles 110 to collect reagents; the first sensor 290 includes a transmitting sensor and a receiving sensor, which are respectively fixed on two sides spatially isolated from the sampling needle 210 and in the same vertical section to detect the height of the reagent in the reagent bottle 110. Through the setting of the up-and-down structure, the traveling distance of the device is reduced, the structure is more compact, which is suitable for the use of micro-devices. At the same time, a controller is added to realize automation and ensure the accuracy of the collection volume.

[0027] In the above embodiment, the reagent tray 120 is provided with card slots evenly distributed along the circumferential direction, and the reagent bottles 110 are placed and fixed in the card slots. The setting of the card slots can be designed according to the size of the reagent bottles, and reagent trays with different areas can be selected. Multiple circles of card slots are concentrically arranged on the reagent tray to increase the collection volume at one time. Fixed silica gel is arranged in the card slots to fix the reagent bottles elastically.

[0028] In the above example, the driving part, the sliding part and the first sensor 290 are electrically connected to the controller. The controller receives the data of the first sensor 290 and controls the start and stop of the driving part and the sliding part. The automation of the device is realized, and the addition of the sensor increases the accuracy of the device.

[0029] In the above embodiment, the driving part includes a first motor 130, a synchronous belt 140, a synchronous belt pulley 150 and a rotating rod 160. Among them, the first motor 130 is fixed at the bottom of the bracket 300; the synchronous belt 140 is installed between the output end of the first motor 130 and the synchronous belt pulley 150; one end of the rotating rod 160 is fixedly installed at the center of the circle of the synchronous belt pulley 150, and the other end is fixedly installed at the center of the bottom of the reagent tray 120. As the synchronous belt 140 rotates, it drives the sliding of the reagent tray 120; the controller controls the start and stop of the first motor 130. The synchronous belt 140 connects the first motor 130 and the rotating rod 160, changing the direction of force transmission, making its structure more compact, reducing the transmission distance, and thus increasing the accuracy of the device. At the same time, in order to increase the versatility and flexibility of the device, the reagent tray 120 is detachably installed on the rotating rod 160, and different-sized reagent trays 120 and reagent bottles 110 are replaced according to reagent requirements.

[0030] In the above embodiment, the driving part is further provided with a positioning assistor, which is installed on the rotating rod 160 to assist the start and stop of the rotating rod 160. Among them, the positioning assistor includes a positioning piece 170 fixedly installed in the middle of the rotating rod 160, and a positioning switch 180 that cooperates with the positioning piece 170 to control the positioning piece 170 to stop rotating; the controller is communicatively connected to the positioning switch 180 to control the closing and opening of the positioning switch 180. The positioning piece 170 uses a photoelectric switch positioning piece, and the positioning switch 180 uses a photoelectric switch, and the two are used in combination. The setting of the positioning assistor, one is to assist the stop of the reagent tray 120, and the other is to avoid the shaking caused by the buffer after the first motor 130 stops, so as to accurately control the position of the reagent tray 120.

[0031] In the above embodiment, a waste liquid tray 190 coaxial with the reagent tray 120 is further provided at the bottom of the reagent tray 120 to collect the waste liquid overflowing from the reagent bottle 110. The waste liquid tray 190 can be fixed to the bottom of the reagent tray 120, or as Figure 1 shown, a bracket is provided on the equipment base to fix the waste liquid tray 190. Its function is to prevent the reagent from dripping during the movement of the sampling needle 210, or to prevent the overflow of the reagent bottle 110 in case of equipment failure, causing pollution to the equipment at the bottom of the reagent tray 120.

[0032] In the above embodiment, as Figure 2 shown, the sliding part includes a second motor 220, a slider 230 installed at the output end of the second motor 220, a linear slide rail 240 that cooperates with the slider 230, and a mounting base plate 250 for installing the linear slide rail 240. Among them, the mounting base plate 250 is fixedly installed on the bracket 300; the linear slide rail 240 is arranged along the movement direction of the sampling needle 210; one side of the slider 230 is fixedly installed with a sampling part; the controller controls the second motor 220 to start. The sliding part is integrally installed on the equipment bracket 300 through the mounting base plate 250 to increase the stability of the equipment.

[0033] In the above embodiment, the sliding part is further provided with a positioning arm 241 fixed to the end of the linear slide rail 240 and a second sensor 260 communicatively connected to the controller. Among them, the positioning arm 241 is provided with a first through hole for the sampling needle 210 to enter and exit; the second sensor 260 is fixed to the positioning arm 241 and located outside the first through hole, and is in the same vertical section as the sampling needle 210, and is used to determine the position of the reagent bottle 110. As Figure 1 shown, the second sensor 260 uses a reflective NPN normally open photoelectric sensor, which is fixed to the positioning arm 241 through a mounting plate and is located below the extension surface at the bottom of the positioning arm 241, and is used to track the bottle mouth of the reagent bottle 110, and can simultaneously determine the position of the reagent bottle 110, and feedback the signal to the controller, so as to accurately control the rotation of the reagent tray 120, ensure that the bottle mouth of the reagent bottle 110 is aligned with the first through hole, and make the sampling needle 210 accurately enter.

[0034] In the above embodiment, the sample injection part includes a support plate 270, a fixing part 280 mounted on the support plate 270, and extension arms 271 provided at both ends of the support plate 270. Among them, the support plate 270 is arranged perpendicular to the movement direction of the sample injection part, one end is fixedly connected to the slider 230 and is provided with a second through hole; the fixing part 280 is a hollow tube and is matched with the second through hole to position the position of the sample injection needle 210; the end of the extension arm 271 is fixed to the support plate 270 and is arranged perpendicular to the support plate 270. The fixing part 280 can also be set into other shapes as long as it can fix the sample injection needle 210, which increases the stability of the sample injection needle 210 and is also for the convenience of replacing the sample injection needle 210.

[0035] In the above embodiment, the first sensor 290 includes a transmitting sensor and a receiving sensor, which are respectively fixed at the other end of the extension arm 271 and are in the same vertical section as the sample injection needle 210 to detect the height of the reagent liquid level in the reagent bottle 110. The transmitting sensor and the receiving sensor are selected as photoelectric sensors. During the detection process, as Figure 3 shown, they are on both sides of the reagent bottle 110, constantly monitoring the liquid inside the reagent bottle 110, and precisely controlling the collection amount of the reagent through the height of the liquid level. Fixing the first sensor 290 on the sample injection part so that it moves simultaneously with the sample injection needle 210 avoids the problem of data delay control when they are separately arranged and increases the precision of the equipment.

[0036] In this embodiment, the second sensor 290 uses a combination of a transmitting sensor and a receiving sensor. The working principle is as follows: The transmitting sensor emits a photoelectric signal, which is projected through the reagent bottle onto the receiving sensor to achieve the transmission of the photoelectric signal. Specifically, the transmitting sensor emits light that penetrates the reagent bottle. Due to the different refractive indices of light for different materials, the different sizes of the reagent bottles, and the different distances for the light signal to enter and exit the reagent bottle, the final transmission path of the light signal will change. Therefore, it is necessary to adjust the position of the receiving sensor according to reagent bottles of different materials and different sizes to ensure that the receiving sensor can receive the light signal. During use, the position where the light signal enters the reagent bottle is set as the preset reagent height. When the reagent reaches this position, due to the addition of the liquid, the refraction of light changes, forcing the receiving sensor to be unable to receive the signal, and thus feeding back the signal to the controller to stop the sample injection. This design can ensure that the sampling needle always remains above the reagent liquid level, avoiding reagent contamination caused by the sampling needle being immersed in the reagent, and increasing the accuracy of detection. At the same time, it solves the error caused by using a single sensor. Whether it is a weight sensor or a laser sensor, they both need to sense the weight or emit a signal and then feed back the signal to the controller, and it takes twice as long to control the start and stop of the sample injection. By using a combination of a transmitting sensor and a receiving sensor, the receiving sensor can transmit the feedback signal to the controller at the same time as the transmitting sensor emits the light signal to control the stop of the sample injection. This design is more suitable for microreactors or devices with extremely low sampling volumes, so as to accurately obtain the collection amount of trace detection reagents.

[0037] In the above embodiment, it is necessary to calibrate the second sensor 290 according to the material of the reagent bottle and the liquid level height of the reagent to ensure that the receiving sensor can receive the signal from the transmitting sensor and continuously feed back the signal to the controller. During the process of reagent collection, when the reagent reaches the predetermined height, due to the refraction effect of the liquid level, the receiving route of the sensing signal is changed, causing the receiving sensor to be unable to receive the signal. At this time, a signal is sent to the controller to stop the sample injection. This design can accurately control the amount of reagent.

[0038] When using the reagent collector of the present application, the sampling needle and the reagent tray can be replaced at any time according to the experimental needs and the needs of the reagent sample, improving the flexibility of the equipment and the operation efficiency. At the same time, the structural design is carried out to increase the stability of the equipment, reduce the movement path, increase the precision of the equipment, and make it more suitable for the use of micro-devices. At the same time, automated control is adopted to reduce the influence of the outside world on the reaction and ensure the accuracy of the data. The combined use of the receiving sensor and the transmitting sensor is more suitable for microreactors or devices with extremely low sampling volumes, so as to accurately obtain the collection amount of trace detection reagents.

[0039] In the description of the specification of this application, terms such as "connection", "installation", "fixation", etc. should be understood in a broad sense. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection or an indirect connection through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0040] In the description of the specification of this application, the descriptions of terms such as "one embodiment", "some embodiments", etc. mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of this application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or instance. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0041] The above is only the preferred embodiment of this application and is not used to limit this application. For those skilled in the art, this application can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the application shall be included within the protection scope of this application.

Claims

1. A reagent collector, characterized in that: include: Bracket; A rotating collection platform, comprising a driving part arranged at the bottom of the support, and a reagent disk arranged at the output end of the driving part and located above the driving part; The sample injector is arranged above the rotating collection platform, and comprises a sample injection needle, a first sensor, a sample injection part for fixing the sample injection needle and the first sensor, and a sliding part for driving the sample injection part to move up and down and installed above the bracket; wherein, The reagent disk is provided with a plurality of slots evenly distributed along the circumference, the reagent bottles are placed in the slots, and the injection needle enters and exits the reagent bottle to collect the reagent; The first sensor comprises a transmitting sensor and a receiving sensor, which are respectively fixed on two sides isolated from the injection needle space and are located in the same vertical section to detect the height of the reagent in the reagent bottle.

2. The reagent collector according to claim 1, characterized in that: The driving part, the sliding part and the first sensor are electrically connected to a controller, and the controller receives data from the first sensor to control the start and stop of the driving part and the sliding part.

3. The reagent collector according to claim 2, characterized in that: The driving unit includes a first motor, a synchronous belt, a synchronous pulley and a rotating rod, wherein: The first motor is fixed to the bottom of the bracket; The synchronous belt is installed between the output end of the first motor and the synchronous belt pulley; One end of the rotating rod is fixedly mounted at the center of the synchronous belt wheel, and the other end is fixedly mounted at the center of the bottom of the reagent tray, and as the synchronous belt rotates, the reagent tray is driven to slide; The controller controls the start and stop of the first motor.

4. The reagent collector according to claim 3, characterized in that: The driving unit is also provided with a positioning assistant, which is installed on the rotating rod to assist the start and stop of the rotating rod, wherein: The positioning assistant comprises a positioning piece whose middle part is fixedly mounted on the rotating rod, and a positioning switch which cooperates with the positioning piece to control the positioning piece to stop rotating; The controller is in communication connection with the positioning switch to control the closing and opening of the positioning switch.

5. The reagent collector according to claim 1, characterized in that: A waste liquid tray coaxially arranged with the reagent tray is also provided at the bottom of the reagent tray to collect waste liquid overflowing from the reagent bottle.

6. The reagent collector according to claim 2, characterized in that: The sliding part includes a second motor, a slider installed at the output end of the second motor, a linear slide rail matched with the slider, and a mounting base plate for mounting the linear slide rail, wherein: The mounting base plate is fixedly mounted on the bracket; The linear slide rail is arranged along the moving direction of the injection needle; The sample injection part is fixedly mounted on one side of the slide block; The controller controls the turning on of the second motor.

7. The reagent collector according to claim 6, characterized in that: The sliding part is also provided with a positioning arm fixed to the end of the linear slide rail and a second sensor connected to the controller in communication, wherein: The positioning arm is provided with a first through hole for the injection needle to enter and exit; The second sensor is fixed to the positioning arm and is located outside the first through hole, and is in the same vertical section as the injection needle, and is used to determine the position of the reagent bottle.

8. The reagent collector according to claim 6, characterized in that: The sample injection part includes a support plate, a fixing part installed on the support plate, and extension arms arranged at both ends of the support plate, wherein: The support plate is arranged perpendicular to the movement direction of the sample injection part, one end of which is fixedly connected to the slider and is provided with a second through hole; The fixing part is in a hollow tubular shape and cooperates with the second through hole to locate the injection needle; The end of the extension arm is fixed to the support plate and is arranged perpendicular to the support plate.

9. The reagent collector according to claim 8, characterized in that: The transmitting sensor and the receiving sensor are respectively fixed to the other end of the extension arm and are in the same vertical section as the injection needle.

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