Device for reducing caking of clinical cell injection

Abstract

The utility model discloses a device for reducing clotting of clinical cell injection, which comprises a base, an object carrying plate and a protective cover, an adapter is placed on the upper surface of the object carrying plate, the protective cover is covered above the object carrying plate, a sliding plate is slidably connected in the protective cover, the lower surface of the sliding plate is slidably connected with a plurality of pressing plates through first springs, and the lower surface of the sliding plate is provided with a plurality of second springs. According to the utility model, through the design of the replaceable adapter, the device can be flexibly adapted to bagged or bottled cell injections with different specifications and shapes, so that the application range is greatly widened, special equipment does not need to be customized for each container, the use cost is reduced, and the universality and flexibility of the equipment are improved; the stability of the cell injection in the uniform shaking process is achieved through the synergistic effect of the protective cover, the fixing plate, the pressing plate and other assemblies, meanwhile, the pressing handle is ingeniously combined with the clamping rod and the clamping groove, the whole fixing and unlocking process is simple and rapid, an operator can conveniently and rapidly complete equipment mounting and dismounting, and the working efficiency is improved.

Description

Technical Field

[0001] The utility model relates to a device for reducing agglomeration of clinical cell injection, belonging to the technical field of cell mixing. Background Technique

[0002] At present, the clinical treatment research of mesenchymal stem cell preparations has developed rapidly globally. Especially, breakthrough progress has been made in immune system diseases, graft-versus-host disease, osteoarticular diseases, etc. And it has a positive therapeutic effect on many refractory diseases, providing new treatment ideas for many diseases with single and scarce treatment means. Clinically, the packaging of mesenchymal stem cell injection is usually divided into two categories: bagged and bottled. Different packaging methods have obvious differences in the clinical use and transportation of mesenchymal stem cell injection. However, no matter what packaging form, due to the action of gravity accumulation, a large number of cells will gather together, greatly increasing the agglomeration rate of cells and increasing the challenge to safety during infusion.

[0003] Due to gravity, a large number of cells will deposit near the plastic sealing line at the bottom of the bag during the storage and transportation of bagged cells. The plastic sealing line of the bag itself may be uneven due to workmanship, which leads to uneven accumulation of cells, with more or fewer cells. During the process of shaking and mixing cells (usually manual mixing), the result of the liquid in the bag flushing the bottom cells is inconsistent, and there may be dead corners where some cells are difficult to be re-shaken into the cell suspension. If a long time is selected at this time and the mixing frequency is increased, it will directly lead to cell death. At the same time, if there are protein substances in the liquid in the bag, a large number of bubbles will be generated, and the rupture of the bubbles will also cause a large amount of damage to the cell membrane, resulting in cell death.

[0004] The volume of conventional bottled mesenchymal stem cell injection is less than that of bagged cell injection. Therefore, to ensure the number of cells input to clinical patients, the number of cells per unit volume of bottled cell injection is higher than that of bagged cell injection. This leads to a more serious cell agglomeration situation in bottled cell injection than in bagged cell injection. In addition, due to the long-term accumulation of cells interacting with each other, the interaction force between cells will greatly affect the biological activity of cells. If a mixing method such as flicking the bottle with fingers is used, such mechanical force will cause a large number of cells to die. Therefore, a more gentle method is needed to mix the highly concentrated cell injection without affecting the cell viability. Content of the Utility Model

[0005] The purpose of the utility model is to provide a device for reducing agglomeration of clinical cell injection to solve the problems put forward in the above background technique.

[0006] To achieve the above purpose, the utility model adopts the following technical scheme: a device for reducing agglomeration of clinical cell injection, including;

[0007] A base, on which a rotating ball is rotatably connected;

[0008] A load-bearing plate, fixed to the upper end of the rotating ball. An adapter is replaceably placed on the upper surface of the load-bearing plate, and an adapter cavity for placing bagged or bottled cells is provided on the adapter;

[0009] A protective cover, which covers the upper part of the load-bearing plate and is used to enclose the upper space of the load-bearing plate;

[0010] A sliding plate, which is slidably connected inside the protective cover. A plurality of pressing plates are slidably connected to the lower surface of the sliding plate through a first spring, and each pressing plate is arranged opposite to an adapter cavity;

[0011] A pressing handle, which is arranged at both ends of the upper surface of the protective cover. The lower end of the pressing handle penetrates through the side wall of the protective cover and is fixed to the side wall of the sliding plate. A second spring for elastically pressing the sliding plate against the inner top wall of the protective cover is sleeved on the pressing handle.

[0012] Preferably, ear plates are provided at both ends of the adapter, and fixing plates for crimping the ear plates are provided on the protective cover.

[0013] Preferably, a lifting plate driven by an electric push rod is arranged inside the base. The lifting plate is connected to an adjusting plate below the load-bearing plate through a top rod. The number of electric push rods is two, symmetrically connected to both sides of the lifting plate, and is used to adjust the inclination angle of the adjusting plate.

[0014] Preferably, a motor is fixedly installed on the base, and a cross bar is fixedly connected to the output shaft of the motor. The top rod is slidably sleeved at the end of the cross bar.

[0015] Preferably, balls are additionally provided at both ends of the top rod.

[0016] Preferably, a plurality of third springs for resetting the adjusting plate are provided between the adjusting plate and the base. A telescopic rod is provided inside the inner ring of each third spring, and both ends of the telescopic rod are connected to the side walls of the adjusting plate and the base through universal balls respectively.

[0017] Preferably, the number of the second springs on the pressing handle is two, which are respectively sleeved on the vertical rod of the pressing handle. The lower end of the second spring abuts against the side wall of the protective cover, and the upper end of the second spring abuts against the side wall of the pressing handle.

[0018] Preferably, a clinical cell injection device for reducing agglomeration further includes a clamping structure. The clamping structure includes a clamping rod arranged on the pressing handle and columns arranged at both ends of the load-bearing plate. The clamping rod is rotatably connected to the pressing handle through a torsion spring. A plurality of clamping grooves are provided on the side wall of the clamping rod, and clamping blocks matched with the clamping grooves are provided on the side wall of the column.

[0019] Compared with the prior art:

[0020] 1. Through the detachable adapter design, the utility model can flexibly adapt to cell injection solutions in bags or bottles of different specifications and shapes, greatly broadening the scope of use. There is no need to customize exclusive equipment for each type of container, reducing the usage cost and improving the versatility and flexibility of the equipment. The coordinated action of components such as the protective cover, fixed plate, and pressing plate realizes the stability of the cell injection solution during the shaking process. At the same time, the ingenious combination of the pressing handle, clamping rod, and clamping groove makes the entire fixing and unlocking process simple and fast, facilitating the operator to quickly complete the installation and disassembly of the equipment and improving work efficiency.

[0021] 2. The up-and-down movement of the lifting plate of the utility model realizes the tilting adjustment of the adjustment plate, thereby controlling the tilting amplitude and shaking force of the loading plate. When the lifting plate moves towards the adjustment plate, it pushes the ejector rod upward. The upward movement of the ejector rod causes the tilting angle of the adjustment plate to increase, resulting in an increase in the tilting amplitude of the loading plate. At this time, if the rotation speed of the motor is synchronously increased, the shaking force of the loading plate will be further enhanced, improving the shaking effect of the cell injection solution. On the contrary, when the lifting plate moves in the reverse direction, the ejector rod moves downward accordingly, the tilting angle of the adjustment plate decreases, and the tilting amplitude of the loading plate also decreases. At the same time, if the rotation speed of the motor is reduced, the shaking force of the loading plate will be weakened, thus realizing the flexible adjustment of the shaking amplitude and frequency of the cell injection solution to optimize the shaking effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 is a schematic structural diagram of the utility model;

[0023] Figure 2 is a cross-sectional view of the overall structure of the utility model;

[0024] Figure 3 is an exploded view of the loading plate and the protective cover of the utility model;

[0025] Figure 4 is a schematic structural diagram of the base, loading plate, rotating ball, and adjustment plate of the utility model;

[0026] Figure 5 is a schematic structural diagram of the protective cover and the fixed plate of the utility model;

[0027] Figure 6 is a cross-sectional view of the loading plate, adapter, protective cover, and fixed plate of the utility model.

[0028] In the figures:

[0029] 1. Base, 2. Loading plate, 3. Rotating ball, 4. Adjustment plate;

[0030] 5. Adapter, 501. Adaptation cavity, 502. Ear plate;

[0031] 6. Protective cover, 601. Fixed plate, 602. Slide plate, 7. First spring, 8. Pressing plate, 9. Pressing handle, 10. Second spring;

[0032] 11. Torsion spring, 12. Clamping rod, 1201. Card slot, 13. Column, 14. Clamping block;

[0033] 15. Motor, 16. Cross bar, 17. Electric push rod, 18. Lifting plate, 19. Jack rod, 20. Third spring, 21. Telescopic rod;

[0034] 22. Temperature control module, 23. Control module. Specific implementation mode

[0035] The following uses specific embodiments to illustrate the present invention, but it is not a limitation to the invention.

[0036] Embodiment 1

[0037] As Figures 1-6 shown, in this embodiment, a device for reducing agglomeration of a clinical cell injection solution is provided, including a base 1. Above the base 1, there is a carrier plate 2 for placing bagged or bottled cells. The upper surface of the carrier plate 2 is replaceably provided with an adapter 5. The adapter 5 is provided with an adaptation cavity 501 for placing bagged or bottled cells, and the adaptation cavity 501 is adapted to the bagged or bottled shape for containing the cell injection solution;

[0038] Above the carrier plate 2, there is a protective cover 6 for closing the upper part of the carrier plate 2;

[0039] Both ends of the adapter 5 are provided with ear plates 502, and on the protective cover 6, there is a fixed plate 601 for pressing and connecting the ear plates 502 to fix the adapter 5;

[0040] A slide plate 602 is slidably connected inside the protective cover 6. The lower surface of the slide plate 602 and directly above each adaptation cavity 501 is slidably connected with a pressing plate 8 through a first spring 7;

[0041] Both ends of the upper surface of the protective cover 6 are provided with U-shaped pressing handles 9. The pressing handles 9 penetrate through the side wall of the protective cover 6 and are fixed on the side wall of the slide plate 602. And two second springs 10 are sleeved on the pressing handle 9. Two second springs 10 are fixed on each pressing handle 9. The two second springs 10 are sleeved on the vertical rod of the pressing handle 9. The lower end of the second spring 10 abuts against the side wall of the protective cover 6, and the upper end of the second spring 10 abuts against the side wall of the pressing handle 9, so that the slide plate 602 is elastically pressed against the inner top wall of the protective cover 6 by the second spring 10;

[0042] A clamping rod 12 is rotatably connected to each pressing handle 9 through a torsion spring 11. A plurality of clamping grooves 1201 are evenly formed on the side wall of the clamping rod 12. A column 13 is provided at each end of the carrying plate 2. A clamping block 14 cooperating with the clamping groove 1201 is provided on the side wall of the column 13;

[0043] The placing process is as follows: Select a suitable adapter 5 and place it on the carrying plate 2. Then, put the bagged or bottled cell injection solution into the adaptation cavity 501. Then, cover the protective cover 6 on the carrying plate 2. At this time, the fixing plate 601 will press the ear plate 502. Then, press the pressing handle 9. The pressing handle 9 compresses the second spring 10 and slides downward. At the same time, the pressing handle 9 drives the sliding plate 602 to slide downward. During the sliding process, the pressing plate 8 moves towards the adaptation cavity 501. When the pressing plate 8 presses the upper surface of the bag or bottle body, the clamping block 14 is clamped inside the corresponding clamping groove 1201. At this time, the protective cover 6, the adapter 5, and the bag and bottle bodies containing the cell injection solution are fixed simultaneously, which is beneficial to the rapid installation of the equipment;

[0044] When the clamping rod 12 is rotated and the clamping block 14 is disengaged from the inside of the clamping groove 1201, the protective cover 6 can be removed from the carrying plate 2, which is convenient for removing the shaken cell injection solution and replacing the adapter 5;

[0045] As Figure 2 shown, a temperature control module 22 is further provided below the carrying plate 2. The temperature control module 22 can accurately control the temperature in the area above the carrying plate 2 to keep it within the optimal temperature range required by the cells, thereby ensuring the activity and stability of the cells.

[0046] Embodiment 2

[0047] As Figures 1-4 shown, in this embodiment, a rotating ball 3 is connected to the base 1. The upper end of the rotating ball 3 penetrates through the side wall of the base 1 and is fixed to the bottom of the carrying plate 2. The lower end of the rotating ball 3 is fixed with an adjusting disc 4. An elevating disc 18 is slidably connected to the inside of the base 1 and below the adjusting disc 4 through an electric push rod 17. A top rod 19 is provided between the elevating disc 18 and the adjusting disc 4. The number of electric push rods 17 can be set to two. The outputs of the two electric push rods 17 are symmetrically connected to both sides of the elevating disc 18. When the two electric push rods 17 run synchronously, the two electric push rods 17 drive the elevating disc 18 to move horizontally towards or away from the adjusting disc 4;

[0048] A motor 15 is fixedly installed on the base 1. A cross bar 16 is vertically and fixedly connected to the output shaft of the motor 15. The rotation axis of the cross bar 16 coincides with the center of the rotating ball 3. The top rod 19 is slidably sleeved at the end of the cross bar 16. When the motor 15 is started, the cross bar 16 drives the top rod 19 to rotate between the elevating disc 18 and the adjusting disc 4;

[0049] As the motor 15 drives the cross bar 16 to rotate, the cross bar 16 drives the ejector rod 19 to rotate in a circle between the adjusting disc 4 and the lifting disc 18, causing the adjusting disc 4 to shake. Since the adjusting disc 4, the rotating ball 3 and the loading plate 2 are integrated, the loading plate 2 shakes, so that the cells in the cell injection solution can be mixed evenly.

[0050] In order to reduce the friction between the two ends of the ejector rod 19 and the side walls of the lifting disc 18 and the adjusting disc 4, balls are added at both ends of the ejector rod 19, which can reduce the friction between the adjusting disc 4 and the lifting disc 18 and enable the ejector rod 19 to run more smoothly.

[0051] When the lifting disc 18 moves towards the adjusting disc 4, the lifting disc 18 pushes the ejector rod 19 to move upward. At this time, the ejector rod 19 moves upward, the inclination angle of the adjusting disc 4 increases, and the inclination amplitude of the loading plate 2 increases. At the same time, if

[0052] the rotation speed of the motor 15 is further increased, the shaking force of the loading plate 2 can be increased at this time; conversely, the ejector rod 19 moves downward, the inclination angle of the adjusting disc 4 decreases, and the inclination amplitude of the loading plate 2 decreases. At the same time, if the rotation speed of the motor 15 is further decreased, the shaking force of the loading plate 2 can be decreased at this time. The amplitude and frequency of the shaking of the cell injection solution can be effectively adjusted, improving the effect of cell shaking.

[0053] A plurality of third springs 20 for resetting the adjusting disc 4 are arranged between the upper end surface of the adjusting disc 4 and the base 1. When the ejector rod 19 pushes one side of the adjusting disc 4 upward, the third spring 20 on this side is compressed. At this time, the compressed third spring 20 can elastically press the adjusting disc 4 downward for resetting. An expansion rod 21 is arranged inside each third spring 20. Both ends of the expansion rod 21 are connected to the side walls of the adjusting disc 4 and the base 1 through universal balls respectively. The expansion rod 21 can limit the axial compression of the third spring 20. The expansibility of the expansion rod 21 and the universal balls arranged at both ends thereof can enable the expansion rod 21 to adapt to the relative deflection of the adjusting disc 4.

[0054] In addition, as Figure 1 shown, a control module 23 is arranged on the base 1. The control module 23 is provided with a display screen and a plurality of buttons. The plurality of buttons can be used to control the operation of the motor 15 and the electric push rod 17 (for example: starting or adjusting the rotation speed of the motor 15, starting and stopping the electric push rod 17, etc.). The display screen is used to display the data information during the shaking process (for example: the rotation speed information of the motor 15, etc.).

[0055] Finally, it should be noted that the above embodiments are only used to illustrate rather than limit the technical solutions of the present invention. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that the present invention can still be modified or equivalently replaced. Any modification or partial replacement without departing from the spirit and scope of the present invention shall be covered by the scope of the claims of the present invention.

Claims

1. A device for reducing agglomeration of clinical cell injection, characterized in that: include: A base (1) on which a rotatably connected rotating ball (3) is disposed; A carrier plate (2) is fixed to the upper end of the rotating ball (3), and an adapter (5) is replaceably placed on the upper surface of the carrier plate (2), and an adaptor cavity (501) for placing bagged or bottled cells is provided on the adapter (5); A protective cover (6), the protective cover (6) being arranged above the loading plate (2) and used for sealing the space above the loading plate (2); A slide plate (602), the slide plate (602) being slidably connected in the protective cover (6), and a plurality of pressing plates (8) being slidably connected to the lower surface of the slide plate (602) via a first spring (7), and each pressing plate (8) being arranged opposite to an adapting cavity (501); A pressing handle (9) is arranged at two ends of the upper surface of the protective cover (6), the lower end of the pressing handle (9) passes through the side wall of the protective cover (6) and is fixed on the side wall of the slide plate (602), and a second spring (10) is sleeved on the pressing handle (9) for pressing the slide plate (602) against the inner top wall of the protective cover (6).

2. A device for reducing agglomeration of clinical cell injection according to claim 1, characterized in that: Both ends of the adapter (5) are provided with ear plates (502), and the protective cover (6) is provided with a fixing plate (601) for crimping the ear plates (502).

3. A device for reducing agglomeration of clinical cell injection according to claim 1, characterized in that: The base (1) is provided with a lifting plate (18) driven by an electric push rod (17); the lifting plate (18) is connected to an adjustment plate (4) below the loading plate (2) via a push rod (19); there are two electric push rods (17) symmetrically connected to both sides of the lifting plate (18) for adjusting the inclination angle of the adjustment plate (4).

4. A device for reducing agglomeration of clinical cell injection according to claim 3, characterized in that: A motor (15) is fixedly mounted on the base (1), a crossbar (16) is fixedly connected to the output shaft of the motor (15), and the top rod (19) is slidably sleeved on the end of the crossbar (16).

5. A device for reducing agglomeration of clinical cell injection according to claim 3 or 4, characterized in that: Ball bearings are additionally provided at both ends of the push rod (19).

6. A device for reducing agglomeration of clinical cell injection according to claim 4, characterized in that: A plurality of third springs (20) for resetting the adjusting disk (4) are arranged between the adjusting disk (4) and the base (1); a telescopic rod (21) is arranged on the inner ring of each third spring (20); and two ends of the telescopic rod (21) are respectively connected to the side walls of the adjusting disk (4) and the base (1) through universal balls.

7. A device for reducing agglomeration of clinical cell injection according to claim 1, characterized in that: There are two second springs (10) on the pressing handle (9), which are respectively sleeved on the vertical rod of the pressing handle (9), the lower end of the second spring (10) abuts against the side wall of the protective cover (6), and the upper end of the second spring (10) abuts against the side wall of the pressing handle (9).

8. A device for reducing agglomeration of clinical cell injection according to claim 1, characterized in that: The invention also comprises a clamping structure, wherein the clamping structure comprises a clamping rod (12) arranged on the pressing handle (9) and columns (13) arranged at both ends of the loading plate (2); the clamping rod (12) is rotatably connected to the pressing handle (9) via a torsion spring (11); a side wall of the clamping rod (12) is provided with a plurality of clamping grooves (1201); and a side wall of the column (13) is provided with a clamping block (14) that cooperates with the clamping grooves (1201).

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