Filtering device for producing ritonavir intermediate BDH

Abstract

The utility model discloses a filter device for Ritonavir intermediate BDH production, which is characterized in that a flat plate is erected in a tank body along the diameter direction, a first through hole is formed in the center of the flat plate in a penetrating manner, a sliding cavity is formed in the flat plate along the length direction, and a push-pull plate is arranged in the sliding cavity of the flat plate in a sliding manner; a first through hole is formed in the upper surface of the flat plate, a second through hole is formed in the end, close to the push-pull rod, of the push-pull plate, a conical sieve plate is arranged at the position, located at the first through hole, of the upper surface of the flat plate, and a filter residue discharging pipe is arranged at the position, located at the first through hole, of the lower surface of the flat plate. The push-pull plate is matched with the first through hole of the flat plate through the second through hole to realize deslagging, the filter plate or any assembly does not need to be taken out during deslagging, the convenience is greatly improved, the conical sieve plate is adopted for filtering, compared with a traditional plane filter plate structure, blockage is not prone to occurring, the flow speed is hardly affected on the premise that filter residues are not stacked, and therefore the production efficiency is guaranteed.

Description

Technical Field

[0001] The utility model relates to the technical field of filtering equipment, in particular to a filtering device for the production of ritonavir intermediate BDH. Background Technique

[0002] (2S, 3S, 5S)-5-(tert-butoxycarbonyl)amino-2-amino-3-hydroxy-1,6-diphenylhexane, abbreviated as BDH, is a white to off-white powder, insoluble in water, soluble in methanol, slightly soluble in acetonitrile, and is mainly used as an intermediate for the anti-AIDS drug ritonavir.

[0003] In the production process, after performing Grignard reaction, condensation reaction, addition reaction and two subsequent reactions, the fifth intermediate is prepared. Finally, the fifth intermediate is subjected to reduction reaction, end point detection with methanol, palladium carbon and ammonium formate, and then filtered. After filtration, vacuum desolvation, dissolution, alkali washing, salt washing, water washing, pulping, crystallization and drying are carried out to obtain ritonavir intermediate BDH.

[0004] Among them, the traditional filtering device is generally a flat filter screen structure. During filtration, the filter residue adheres to the filter screen. The contact point between the mixed liquid and the filter screen for the first time when flowing down is generally the same point, and the filter residue also blocks at this point first, resulting in the mixed liquid flowing outward along the filter residue first, and then passing through the unblocked part of the filter screen, thereby reducing the flow rate, and further reducing the overall processing efficiency. Moreover, for the existing flat filter screen, when cleaning, the filter plate generally needs to be taken out, which is not convenient enough. Therefore, an improved technology is urgently needed to solve this problem existing in the prior art. Content of the Utility Model

[0005] The purpose of the utility model is to provide a filtering device for the production of ritonavir intermediate BDH. A flat plate is arranged inside the tank body, and a push-pull plate is slidably arranged inside the flat plate. The push-pull plate cooperates with the first through hole of the flat plate through the second through hole to realize slag discharge. When cleaning the slag, there is no need to take out the filter plate or any components, and the convenience is greatly improved. Moreover, a conical sieve plate is used for filtration. Compared with the traditional flat filter plate structure, it is not easy to be blocked, and the flow rate is hardly affected on the premise of not being filled with filter residue, so as to ensure the production efficiency, so as to solve the problems put forward in the above background technique.

[0006] To achieve the above object, the present utility model provides the following technical solutions: A filtering device for the production of ritonavir intermediate BDH, comprising a tank body, an upper cover, a lower cover, a feed inlet, a discharge outlet, a flat plate, a hydraulic cylinder, a push-pull rod, a push-pull plate, a conical sieve plate, a filter residue discharge pipe and a filter residue discharge port. An upper cover is provided at the top of the tank body, a lower cover is provided at the bottom of the tank body, a feed inlet is provided at the top of the upper cover, a discharge outlet is provided at the bottom of the lower cover. A flat plate is arranged inside the tank body along the diameter direction, and a first through hole is penetrated at the central position of the flat plate. A sliding cavity is opened inside the flat plate along the length direction, and the sliding cavity is communicated with the first through hole. A hydraulic cylinder is installed on the outer surface of the tank body along the arrangement direction of the flat plate through a hydraulic cylinder seat. The piston rod of the hydraulic cylinder is connected to one end of the push-pull rod through a connecting member, and the other end of the push-pull rod is connected to the push-pull plate. The push-pull plate is slidably arranged in the sliding cavity of the flat plate. A second through hole is opened at one end of the push-pull plate close to the push-pull rod. A conical sieve plate is provided on the upper surface of the flat plate at the position of the first through hole, and a filter residue discharge pipe is provided on the lower surface of the flat plate at the position of the first through hole. A filter residue discharge port is provided on the side surface of the lower cover, and the end of the filter residue discharge pipe far from the flat plate is communicated with the filter residue discharge port.

[0007] Preferably, for a filtering device for the production of ritonavir intermediate BDH provided by the present utility model, wherein the conical sieve plate is densely provided with sieve holes, a reinforcing rubber ring is provided on the upper surface of the conical sieve plate, the outer diameter of the reinforcing rubber ring is the same as the inner diameter of the tank body, an inner hem is provided at the bottom of the conical sieve plate, and the inner hem is connected to the upper surface of the flat plate through bolts.

[0008] Preferably, for a filtering device for the production of ritonavir intermediate BDH provided by the present utility model, wherein exhaust holes are provided on both sides of the sliding cavity of the flat plate far from the hydraulic cylinder, and vertical plates are provided at both ends of the flat plate, and the vertical plates are connected to the inner wall of the tank body through bolts.

[0009] Preferably, for a filtering device for the production of ritonavir intermediate BDH provided by the present utility model, wherein a plurality of support seats are uniformly provided on the outer surface of the tank body.

[0010] Preferably, for a filtering device for the production of ritonavir intermediate BDH provided by the present utility model, wherein an observation window is further provided on the side wall of the tank body.

[0011] Compared with the prior art, the beneficial effects of the present utility model are:

[0012] (1) A flat plate is provided inside the tank body, a push-pull plate is slidably arranged inside the flat plate, and the push-pull plate cooperates with the first through hole of the flat plate through the second through hole to realize slag discharge. When cleaning the slag, there is no need to take out the filter plate or any components, greatly improving the convenience.

[0013] (2) The conical sieve plate is used for filtration. Compared with the traditional flat sieve plate structure, it is not easy to be blocked. Without being filled with filter residue, it hardly affects the flow rate, thus ensuring the production efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic cross-sectional structure diagram of the present utility model;

[0015] Figure 2 For the attached Figure 1 It is an enlarged structure diagram of the marked position A in the figure;

[0016] Figure 3 It is a schematic cross-sectional structure diagram of the present utility model at the flat plate;

[0017] Figure 4 It is a schematic structure diagram of the conical sieve plate;

[0018] Figure 5 It is a schematic appearance structure diagram of the present utility model.

[0019] In the figure: tank body 1, upper cover 2, lower cover 3, feed inlet 4, discharge outlet 5, flat plate 6, hydraulic cylinder 7, push-pull rod 8, push-pull plate 9, conical sieve plate 10, filter residue discharge pipe 11, filter residue discharge port 12, first through hole 13, sliding cavity 14, second through hole 15, sieve hole 16, reinforcing rubber ring 17, inner folded edge 18, exhaust hole 19, vertical plate 20, support seat 21, observation window 22. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0020] Next, the technical solutions of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present utility model;

[0021] It should be noted that in the description of the present utility model, it should be noted that the orientation or positional relationship indicated by the terms "inner", "outer", "upper", "lower", "both sides", "one end", "the other end", "left", "right", etc. is based on the orientation or positional relationship shown in the accompanying drawings. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present utility model.

[0022] Please refer to Figures 1-5, the utility model provides a technical solution: a filtering device for the production of ritonavir intermediate BDH, including a tank body 1, an upper cover 2, a lower cover 3, a feed inlet 4, a discharge outlet 5, a flat plate 6, a hydraulic cylinder 7, a push-pull rod 8, a push-pull plate 9, a conical sieve plate 10, a filter residue discharge pipe 11 and a filter residue discharge port 12. An upper cover 2 is arranged at the top end of the tank body 1, a lower cover 3 is arranged at the bottom end of the tank body 1, a feed inlet 4 is arranged at the top end of the upper cover 2, a discharge outlet 5 is arranged at the bottom of the lower cover 3. A flat plate 6 is arranged inside the tank body 1 along the diameter direction, and a first through hole 13 is formed through the center position of the flat plate 6. A sliding cavity 14 is formed inside the flat plate 6 along the length direction. Exhaust holes 19 are arranged on both sides of the end of the sliding cavity 14 of the flat plate 6 away from the hydraulic cylinder 7 to ensure the smoothness of the sliding of the push-pull plate 9. Vertical plates 20 are arranged at both ends of the flat plate 6, and the vertical plates 20 are connected to the inner wall of the tank body 1 through bolts to realize the connection and disassembly of the flat plate 6 and the tank body 1. The sliding cavity 14 is communicated with the first through hole 13. A hydraulic cylinder 7 is installed on the outer surface of the tank body 1 along the arrangement direction of the flat plate 6 through a hydraulic cylinder seat. The piston rod of the hydraulic cylinder 7 is connected to one end of the push-pull rod 8 through a connecting piece, and the other end of the push-pull rod 8 is connected to the push-pull plate 9. The push-pull plate 9 is slidably arranged in the sliding cavity 14 of the flat plate 6. A second through hole 15 is formed at one end of the push-pull plate 9 close to the push-pull rod 8. A conical sieve plate 10 is arranged on the upper surface of the flat plate 6 at the position of the first through hole 13. The conical sieve plate 10 is densely provided with sieve holes 16. A reinforcing rubber ring 17 is arranged on the upper surface of the conical sieve plate 10. Through the reinforcing rubber ring 17, the structural strength of the upper end of the conical sieve plate 10 is ensured, and at the same time, it is ensured that the mixed liquid will not flow down between the conical sieve plate 10 and the inner wall of the tank body 1. The outer diameter of the reinforcing rubber ring 17 is the same as the inner diameter of the tank body 1. An inner folded edge 18 is arranged at the bottom of the conical sieve plate 10, and the inner folded edge 18 is connected to the upper surface of the flat plate 6 through bolts to realize the connection with the flat plate 6. A filter residue discharge pipe 11 is arranged on the lower surface of the flat plate 6 at the position of the first through hole 13. A filter residue discharge port 12 is arranged on the side surface of the lower cover 3. One end of the filter residue discharge pipe 11 away from the flat plate 6 is communicated with the filter residue discharge port 12. A plurality of support seats 21 are uniformly arranged on the outer surface of the tank body 1 to realize the overall support. An observation window 22 is also arranged on the side wall of the tank body 1 to facilitate the observation of the inside of the tank body 1.

[0023] Installation method and working principle: First, install the filter residue discharge pipe 11 at the first through hole 13 on the lower surface of the flat plate 6. Then connect the bottom of the filter residue discharge pipe 11 to the filter residue discharge port 12 of the lower cover 3. Subsequently, insert the push-pull rod 8 and the push plate into the sliding cavity 14 of the flat plate 6. Connect the lower cover 3 to the tank body 1, and at the same time insert the flat plate 6 into the tank body 1 from the lower end. Then install both ends of the flat plate 6 on the inner wall of the tank body 1 through the cooperation of the vertical plates 20 and bolts. Next, pass the push-pull rod 8 through the corresponding position of the tank body 1, and then install the hydraulic cylinder 7 and the hydraulic cylinder seat on the outer surface of the tank body 1, and connect the push-pull rod 8 to the piston of the hydraulic cylinder 7 through a connecting piece. Finally, connect the bottom of the conical sieve plate 10 to the upper surface of the flat plate 6 through the inner hem 18 and bolts, and then install the upper cover 2 at the top of the tank body 1 to complete the installation. During use, perform a reduction reaction on the intermediate product, methanol, palladium-carbon, and ammonium formate that have undergone multiple processes. After end-point detection, enter the tank body 1 from the feed port 4. The mixed liquid after the reduction reaction falls on the conical sieve plate 10. Through the sieve holes 16 of the conical sieve plate 10, the mixed liquid flows down through the sieve holes 16 and flows out from the discharge port 5, and the filter residue remains inside the conical sieve plate 10. When clearing the filter residue, the hydraulic cylinder 7 drives the push-pull rod 8 and the push-pull plate 9 to push forward, so that the second through hole 15 of the push-pull plate 9 intersects with the first through hole 13 of the flat plate 6, and the filter residue is discharged from the filter residue discharge pipe 11 and the filter residue discharge port 12. Specifically, when discharging the residue, switch the filtering device to the water path and use the flushing of water to discharge the attached filter residue. The structure of the present utility model is reasonable. A flat plate 6 is arranged inside the tank body 1, and a push-pull plate 9 is slidably arranged inside the flat plate 6. The push-pull plate 9 cooperates with the first through hole 13 of the flat plate 6 through the second through hole 15 to realize residue discharge. When clearing the residue, there is no need to take out the filter plate or any components, which greatly improves the convenience. And a conical sieve plate 10 is used for filtering. Compared with the traditional flat filter plate structure, it is not easy to be blocked, and hardly affects the flow rate on the premise of not being filled with filter residue, thereby ensuring the production efficiency. The overall structure is simple and convenient for assembly and disassembly.

[0024] For those parts not detailed in the present utility model, they are all well-known technologies to those skilled in the art.

[0025] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solutions of the present utility model rather than to limit them. Although the present utility model has been described in detail with reference to the embodiments, those of ordinary skill in the art should understand that the technical solutions of the present utility model can be modified and equivalently replaced without departing from the spirit and scope of the technical solutions of the present utility model, and they should all be covered within the scope of the claims of the present utility model.

Claims

1. A filtering device for producing ritonavir intermediate BDH, characterized in that: The invention comprises a tank body (1), an upper cover (2), a lower cover (3), a feed port (4), a discharge port (5), a plate (6), a hydraulic cylinder (7), a push-pull rod (8), a push-pull plate (9), a conical sieve plate (10), a filter residue discharge pipe (11) and a filter residue discharge port (12), wherein the upper cover (2) is arranged at the top of the tank body (1), the lower cover (3) is arranged at the bottom of the tank body (1), the feed port (4) is arranged at the top of the upper cover (2), the discharge port (5) is arranged at the bottom of the lower cover (3), a plate (6) is arranged inside the tank body (1) along the diameter direction, a first through hole (13) is provided at the center position of the plate (6), a sliding cavity (14) is provided inside the plate (6) and along the length direction, the sliding cavity (14) is communicated with the first through hole (13), and the tank body (1) A hydraulic cylinder (7) is installed on the outer surface of the flat plate (6) through a hydraulic cylinder seat along the arrangement direction of the flat plate (6); the piston rod of the hydraulic cylinder (7) is connected to one end of a push-pull rod (8) through a connecting piece; the other end of the push-pull rod (8) is connected to a push-pull plate (9); the push-pull plate (9) is slidably arranged in a sliding cavity (14) of the flat plate (6); a second through hole (15) is provided at one end of the push-pull plate (9) close to the push-pull rod (8); a conical sieve plate (10) is provided on the upper surface of the flat plate (6) and located at the first through hole (13); a filter residue discharge pipe (11) is provided on the lower surface of the flat plate (6) and located at the first through hole (13); a filter residue discharge port (12) is provided on the side of the lower cover (3); and the filter residue discharge pipe (11) is connected to the filter residue discharge port (12) at one end away from the flat plate (6).

2. A filtration device for producing a ritonavir intermediate BDH according to claim 1, characterized in that: The conical sieve plate (10) is densely covered with sieve holes (16); a reinforcing rubber ring (17) is provided on the upper surface of the conical sieve plate (10); the outer diameter of the reinforcing rubber ring (17) is consistent with the inner diameter of the tank body (1); an inner folding edge (18) is provided at the bottom of the conical sieve plate (10); the inner folding edge (18) is connected to the upper surface of the flat plate (6) by bolts.

3. A filtration device for producing ritonavir intermediate BDH according to claim 1, characterized in that: Exhaust holes (19) are arranged on both sides of the sliding cavity (14) of the flat plate (6) away from one end of the hydraulic cylinder (7), and vertical plates (20) are arranged at both ends of the flat plate (6), and the vertical plates (20) are connected to the inner wall of the tank body (1) through bolts.

4. A filtration device for producing ritonavir intermediate BDH according to claim 1, characterized in that: A plurality of support seats (21) are evenly arranged on the outer surface of the tank body (1).

5. A filtration device for producing ritonavir intermediate BDH according to claim 1, characterized in that: The side wall of the tank body (1) is also provided with an observation window (22).

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