Quantitative sampling device

Abstract

The utility model provides a quantitative sampling device, which comprises: a collection assembly, which comprises a flow guide member and an accommodating member, the flow guide member is connected with the accommodating member, the accommodating member is provided with an accommodating groove, and the flow guide member is used for guiding a sample into the accommodating groove; the measuring assembly comprises a first air bag, a second air bag and a dropper which are communicated with one another, one end of the dropper is connected with the second air bag, and the second air bag is connected with the first air bag; wherein the first air bag is extruded, so that air pressure difference is generated between the second air bag and the dropper and the outside, the sample in the containing groove is quantitatively sucked, the second air bag is used for storing the sample exceeding the range of the dropper, and the first air bag is extruded again, so that the sample in the dropper drips out. The quantitative sampling device provided by the utility model is convenient and rapid in sampling and accurate in quantification, and convenient operation can be realized through integration.

Description

Technical Field

[0001] This application belongs to the technical field of sampling devices, and more specifically, relates to a quantitative sampling device. Background Art

[0002] Saliva is an important human body fluid, mainly composed of liquids secreted by glands such as salivary glands. Water in saliva accounts for about 99%, and other components include organic and inorganic substances. Among them, organic substances mainly include mucin, globulin, amino acids, urea, uric acid, salivary amylase, and lysozyme, and inorganic substances include sodium, potassium, calcium, thiocyanate, chlorine, ammonia, etc. It is reported that saliva contains more than 700 substances, and changes in each substance may indicate the occurrence of certain diseases. Since saliva is closely related to the oral cavity, respiratory, digestive, and endocrine systems, and the components of capillaries and interstitial fluid can penetrate into the salivary glands, saliva is expected to be used as a biomarker for various diseases. Currently, clinical products such as AIDS virus test kits, drug test kits, and oral disease test kits based on saliva detection have been developed. Conducting quantitative diagnosis of human-related diseases based on saliva has important scientific significance and clinical value.

[0003] However, currently, most existing products such as test kits for saliva-based diagnosis adopt qualitative methods and cannot perform quantitative sampling judgment. There is still a lack of quantitative products at the product level. This is mainly because the content of related substances in saliva is relatively low, there are many interfering factors, and it is difficult to perform quantitative sampling. If accurate and low-cost quantification of saliva samples cannot be achieved, the detection will face more uncertainties. Summary of the Utility Model

[0004] The purpose of the embodiments of this application is to provide a quantitative sampling device to solve the technical problem that accurate and low-cost quantification of saliva samples cannot be achieved currently.

[0005] To achieve the above purpose, the embodiments of this application provide a quantitative sampling device, including:

[0006] A collection component, including a diversion member and a receiving member. The diversion member is connected to the receiving member. The receiving member has a receiving groove, and the diversion member is used to divert the sample into the receiving groove;

[0007] A measuring component, including a first airbag, a second airbag, and a dropper that are connected to each other. One end of the dropper is connected to the second airbag, and the second airbag is connected to the first airbag;

[0008] Wherein, by squeezing the first airbag, a pressure difference is generated between the second airbag and the dropper and the outside to quantitatively suck the sample in the receiving groove. The second airbag is used to store the sample exceeding the range of the dropper. Squeezing the first airbag again causes the sample in the dropper to drip out.

[0009] In some embodiments, the first airbag and the second airbag are arranged vertically, and the first airbag is located above the second airbag.

[0010] In some embodiments, the dropper is connected to one end of the second airbag close to the first airbag.

[0011] In some embodiments, the dropper includes:

[0012] A quantitative part, which is arranged vertically, and the end of the quantitative part is a sampling port;

[0013] A connecting part, which has a first port and a second port. The first port is connected to one end of the second airbag close to the first airbag, and the second port is connected to one end of the quantitative part far from the sampling port;

[0014] Wherein, the height of the first port is lower than that of the second port.

[0015] In some embodiments, before sampling, the quantitative part is used as a stirring rod to defoam and homogenize the sample in the receiving tank.

[0016] In some embodiments, a connecting pipe is further provided between the first airbag and the second airbag to enable the first airbag and the second airbag to be connected in an interval.

[0017] In some embodiments, the volume of the second airbag is larger than that of the dropper.

[0018] In some embodiments, the volume of the first airbag is not less than that of the second airbag.

[0019] In some embodiments, an opening is provided at one end of the diversion member far from the receiving tank, and the diversion member is arranged in a horn shape.

[0020] In some embodiments, the diversion member has a guiding inclined surface, and the guiding inclined surface is arranged in a ring shape and is inclined.

[0021] In some embodiments, the diversion member is further provided with a diversion groove, and the diversion groove is used to divert the sample into the receiving tank.

[0022] In some embodiments, the outer surface of the dropper is provided with scales.

[0023] In some embodiments, the volume of the dropper is a preset value, and the range of the preset value is 1 μl to 100 μl.

[0024] In some embodiments, the diversion member and the receiving member are integrally formed, and the dropper, the first airbag and the second airbag are integrally formed.

[0025] The quantitative sampling device provided by the embodiment of the present application is designed with a whole saliva collection component and a saliva quantification measuring component (which can also be used for saliva titration and sample addition, and for saliva defoaming and uniform mixing). The sampling is convenient and fast, and the convenient operation can be realized through integration. Compared with the traditional saliva sampling devices and methods, the embodiment of the present application has systematically designed the four links of saliva collection, homogenization, quantification and titration, and simultaneously solved the disadvantages of inconvenient saliva collection, unevenness, inability to mix, inability to quantify and complex operation in the above four links, providing a new solution for the integration of scientific saliva sample collection, uniform processing, quantitative sampling and titration operation. Moreover, this quantitative sampling device does not need to contact the oral cavity, and has better safety and reliability. Description of the Drawings

[0026] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0027] Figure 1 It is a schematic three-dimensional structure diagram of the quantitative sampling device provided by the embodiment of the present application;

[0028] Figure 2 It is a schematic plan structure diagram of the quantitative sampling device provided by the embodiment of the present application;

[0029] Figure 3 It is a schematic structure diagram of the measuring component provided by the embodiment of the present application;

[0030] Figure 4 It is a schematic structure diagram of the collection component provided by the embodiment of the present application.

[0031] Among them, the description of the reference numerals:

[0032] 10. Collection component; 11. Accommodating member; 110. Accommodating groove; 12. Diversion member; 120. Opening; 121. Guiding inclined surface;

[0033] 20. Measuring component; 21. First airbag; 22. Second airbag; 23. Dropper; 24. Connecting pipe; 231. Quantitative part; 232. Connecting part; 2321. First port; 2322. Second port. Detailed Embodiments

[0034] In the following description, for purposes of illustration and not limitation, specific details such as specific system architectures, technologies, etc. are set forth in order to provide a thorough understanding of the embodiments of the present application. However, those skilled in the art should understand that the present application can also be implemented in other embodiments without these specific details. In other cases, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present application with unnecessary details.

[0035] It should also be understood that the term "and / or" as used in the specification and claims of the present application refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations.

[0036] It should be noted that when an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0037] It should be understood that the orientation or positional relationships indicated by the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. are based on the orientation or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation of the present application.

[0038] In addition, in the description of the specification and claims of the present application, the terms "first", "second", "third", etc. are only used for distinguishing descriptions and should not be construed as indicating or implying relative importance.

[0039] The reference to "one embodiment" or "some embodiments" etc. described in the specification of the present application means that a specific feature, structure, or characteristic described in connection with the embodiment is included in one or more embodiments of the present application. Thus, statements such as "in one embodiment", "in some embodiments", "in other some embodiments", "in still other embodiments", etc. that appear in different places in this specification do not necessarily all refer to the same embodiment, but mean "one or more but not all embodiments", unless otherwise specifically emphasized in another way. The terms "comprising", "including", "having" and their variants all mean "including but not limited to", unless otherwise specifically emphasized in another way. "Plurality" means two or more.

[0040] The quantitative sampling device provided by this application is used for samples that require quantitative analysis. The samples include, but are not limited to, human body fluids and other experimental samples. Specifically, they include saliva, sweat, urine, etc. In the embodiments of this application, saliva is taken as an example for illustration.

[0041] In the prior art, most products such as diagnostic kits based on saliva adopt qualitative methods and cannot perform quantitative sampling judgment. There is still a lack of quantitative products at the product level. This is mainly because the content of relevant substances in saliva is relatively low and there are many interfering factors, making it difficult to perform quantitative sampling. If accurate and low-cost quantification of saliva samples cannot be achieved, it will make the detection face more uncertainties. In addition, saliva sampling involves multiple links such as saliva collection, saliva defoaming / foaming and homogenization treatment, saliva sample quantification, and saliva sample titration. Most of the existing saliva sampling devices and methods only target one of these links, and it is easy to have defects in obtaining saliva samples, and it is difficult to take into account the multiple requirements of collection, homogenization, quantification, and titration. Specifically as follows: Saliva is a mixed liquid secreted by multiple glands. Generally, the requirement for the sampling link is to collect whole saliva samples, and there may be errors in the sample sources collected by different sampling devices. The saliva samples taken out from the human oral cavity generally contain bubbles and cannot be completely homogenized. Therefore, generally, the samples need to be defoamed and homogenized to reduce the self-differences of the samples. Generally, quantitative analysis is required for the detection of saliva substances. Therefore, quantitative treatment is also required for saliva samples. However, there are currently few quantitative devices and there are also certain problems with accuracy.

[0042] Embodiments of this application provide a quantitative sampling device, as Figures 1 to 4 shown, including a collection component 10 and a measurement component 20;

[0043] The collection component 10 includes a diversion member 12 and a containing member 11. The diversion member 12 is connected to the containing member 11. The containing member 11 has a containing groove 110. The diversion member 12 is used to divert the sample into the containing groove 110;

[0044] The measurement component 20 includes a first airbag 21, a second airbag 22 and a dropper 23 that are connected to each other. One end of the dropper 23 is connected to the second airbag 22, and the second airbag 22 is connected to the first airbag 21;

[0045] Wherein, by squeezing the first airbag 21, a pressure difference is generated between the second airbag 22 and the dropper 23 and the outside to quantitatively aspirate the sample in the containing groove 110. The second airbag 22 is used to store the sample exceeding the range of the dropper 23. Squeezing the first airbag 21 again causes the sample in the dropper 23 to drip out.

[0046] The collection component 10 of the quantitative sampling device provided by the embodiment of the present application includes a diversion member 12 and a receiving member 11. The saliva (or other samples) is diverted to the receiving groove 110 of the receiving member 11 through the diversion member 12 for storage. Before quantitative measurement and sample addition, a dropper 23 can be used to stir and mix the saliva in the receiving groove 110 to remove foam, make it evenly mixed, and facilitate subsequent quantitative measurement and sample addition; the first airbag 21, the second airbag 22 and the dropper 23 in the measurement component 20 effectively utilize the siphon principle. By squeezing the first airbag 21, the air in the second airbag 22 and the dropper 23 is discharged, creating an air pressure difference with the outside world. Then, one end of the dropper 23 is placed in the receiving groove 110 containing saliva, and the first airbag 21 is released. Under the action of the pressure difference, the saliva will be sucked into the dropper 23. If there is more saliva, the saliva exceeding the range of the dropper 23 will be sucked into the second airbag 22 for storage, thus realizing accurate quantitative measurement; when sample addition is required, the dropper 23 is moved to the corresponding container, and the first airbag 21 is squeezed again to completely discharge the sample in the dropper 23, realizing the titration sample addition operation.

[0047] In this way, the quantitative sampling device provided by the present application is convenient and fast for sampling, and can realize convenient operation through integration. Compared with traditional saliva sampling devices and methods, the embodiment of the present application has systematically designed the four links of saliva collection, homogenization, quantification and titration, and simultaneously solves the disadvantages of inconvenient collection, unevenness, inability to mix, inability to quantify and complex operation in the above four links, providing a new solution for the integration of scientific collection, uniform processing, quantitative sampling and titration sample addition operation of saliva samples.

[0048] In some embodiments of the present application, as Figures 1 to 3 shown, the first airbag 21 and the second airbag 22 are vertically arranged, and the first airbag 21 is located above the second airbag 22. With this arrangement, it is ensured that the sample exceeding the range of the dropper 23 will be stored in the second airbag 22 and will not enter the first airbag 21, so as not to affect quantitative measurement and sample addition.

[0049] In some embodiments of the present application, as Figures 1 to 3 shown, the dropper 23 is connected to the end of the second airbag 22 close to the first airbag 21. Thus, the second airbag 22 can store as much excess saliva as possible.

[0050] In some embodiments of the present application, as Figures 1 to 3 shown, the dropper 23 includes a quantitative part 231 and a connecting part 232;

[0051] The quantitative part 231 is vertically arranged, and the end of the quantitative part 231 is a sampling port;

[0052] The connecting portion 232 has a first port 2321 and a second port 2322. The first port 2321 is connected to one end of the second airbag 22 close to the first airbag 21, and the second port 2322 is connected to one end of the metering portion 231 away from the sampling port.

[0053] Wherein, the height of the first port 2321 is lower than that of the second port 2322.

[0054] In this way, when performing quantitative measurement, the excess saliva sample will enter the second airbag 22 through the connecting portion 232. The height of the first port 2321 is lower than that of the second port 2322, that is, the connecting portion 232 is inclined. Under the action of gravity, it can ensure that there is no sample in the connecting portion 232, thereby improving the accuracy of measurement and titration and sample addition.

[0055] In some embodiments of the present application, the outer surface of the dropper 23 is provided with scales. In some embodiments, the volume of the dropper 23 is a preset value, and the range of the preset value is 1 μl to 100 μl. In some embodiments, the range of the preset value can be any value within the range of 1 μl to 100 μl, such as 1 μl, 5 μl, 10 μl, 15 μl, 20 μl, 25 μl, 30 μl, 55 μl, 65 μl, 75 μl, 85 μl, 95 μl, 100 μl, etc. The dropper 23 can quantitatively absorb different volumes of saliva by using the siphon principle. The quantitative volume is composed of the length and equivalent diameter of the dropper 23. The equivalent diameter is defined as the maximum width of the cross-section, where the volume range is 1 μl - 100 μl, preferably 25 μl; the length range is 5 mm to 100 mm, preferably 25 mm. In application, the volume of the dropper 23 specifically refers to the volume of the metering portion 231, because the connecting portion 232 mainly plays a role of connection and vacuum, so as to achieve accurate measurement.

[0056] In some embodiments of the present application, before sampling, the metering portion 231 is used as a stirring rod to defoam and mix the sample in the receiving groove 110 evenly. In some embodiments, the saliva collected can also be defoamed and evenly mixed by directly shaking the bottom of the receiving member 11.

[0057] In some embodiments of the present application, as Figures 1 to 3 shown, a connecting pipe 24 is further provided between the first airbag 21 and the second airbag 22 to enable the first airbag 21 and the second airbag 22 to be connected in series at intervals. On the one hand, the presence of the connecting pipe 24 is beneficial to increasing the flow rate of the fluid generated in the first airbag 21, so that the air in the second airbag 22 and the dropper 23 can be quickly discharged, and rapid and convenient sampling can be carried out; on the other hand, the first airbag 21 and the second airbag 22 are also separated from each other and do not affect each other.

[0058] In some embodiments of the present application, the volume of the second airbag 22 is larger than that of the dropper 23; such a design is to be able to store samples exceeding the range of the dropper 23. In applications, the second airbag 22 can collect saliva exceeding the range of the dropper 23 and be used as a marker to check whether the quantitative aspiration of saliva is completed. The volume range of the second airbag 22 is 100 μl to 50 ml, preferably 5 ml.

[0059] In some embodiments of the present application, the volume of the first airbag 21 is not less than that of the second airbag 22. The first airbag 21 mainly provides the power for aspirating and releasing saliva. By pinching the first airbag 21, saliva can be collected from the saliva receiving groove 110 into the dropper 23 and the second airbag 22. The volume range of the first airbag 21 is 200 μl to 100 ml, preferably 10 ml. The volume range of the connecting tube 24 is 1 ml to 100 ml, preferably 10 ml; the height range is 5 mm - 100 mm, preferably 10 mm. It should be noted that by reasonably setting the volumes of the first airbag 21 and the second airbag 22, it is possible to avoid aspirating too much or too little saliva, thereby ensuring the quantitative measurement of saliva.

[0060] In some embodiments of the present application, such as Figure 1 , Figure 2 and Figure 4 , an opening 120 is provided at one end of the flow guide member 12 away from the receiving groove 110, and the flow guide member 12 is arranged in a trumpet shape. In some embodiments, the flow guide member 12 has a guiding inclined surface 121, and the guiding inclined surface 121 is arranged in a ring shape and is inclined. In this way, the saliva sample can be drained into the receiving groove 110 for convergence under the action of gravity, and the inclined surface setting reduces the flow rate of saliva and avoids the situation of insufficient sample volume caused by splashing. In some embodiments, a flow guide groove (not shown in the figure) is also provided on the flow guide member 12. In this way, the saliva can be further guided.

[0061] The saliva sample can flow naturally into the receiving groove 110 for convergence through the trumpet-shaped opening 120 by gravity. The trumpet-shaped opening 120 can be circular, oval, square or irregular in shape. Taking the circular shape as an example, the diameter is 5 mm to 50 mm, preferably 25 mm; the receiving member 11 can be circular, oval, square or irregular in shape. Taking the circular shape as an example, the diameter is 0.1 mm to 20 mm, preferably 5 mm; the height of the receiving groove 110 is 5 mm to 50 mm, preferably 10 mm. A groove protruding inward can be provided at the middle position on the inner side of the receiving groove 110, and its main purpose is to provide a channel for the saliva quantitative measurement assembly 20. To prevent saliva from flowing onto the surface of the saliva quantitative measurement assembly 20 during the process of flowing from the position of the trumpet-shaped opening 120 to the receiving groove 110, some guiding grooves are provided at the position where the inwardly protruding part contacts the saliva to guide the saliva into the receiving groove 110.

[0062] In a specific embodiment, the collection component 10 is composed of a disposable storage container. The upper end thereof is a diversion member 12 with a flared opening 120, which can directly collect saliva. The lower end is a receiving member 11 with a conical flat bottom shape, which can accumulate the saliva sample collected by the diversion member 12. The saliva sample can flow naturally from the diversion member 12 into the receiving groove 110 by gravity for convergence. The diversion member 12 is circular in shape with a diameter of 25 mm; the receiving member 11 is circular with a diameter of 5 mm; and the height of the storage container is 10 mm.

[0063] In some embodiments of the present application, the diversion member 12 and the receiving member 11 are integrally formed, and the dropper 23, the first airbag 21 and the second airbag 22 are integrally formed.

[0064] In application, the collection component 10 and the measuring component 20 can be prepared from ordinary polymer plastics by processes such as hot pressing. The raw materials are easy to obtain and the cost is low, which is suitable for mass production. Specifically, the dropper 23, the first airbag 21, the second airbag 22 and the connecting tube 24 are prepared from a disposable straw. In this way, the preparation cost is effectively reduced, and it is for single use, with higher accuracy and safety.

[0065] In the above embodiments, the descriptions of the respective embodiments have their own emphases. For parts not detailed or recorded in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0066] The above-described embodiments are only used to illustrate the technical solutions of the present application, and are not intended to limit the same; although the present application has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the various embodiments of the present application, and should all be included within the protection scope of the present application.

Claims

1. A quantitative sampling device, characterized in that: include: A collection component, comprising a flow guide and a receiving member, wherein the flow guide is connected to the receiving member, the receiving member has a receiving groove, and the flow guide is used to guide the sample into the receiving groove; A measuring component, comprising a first airbag, a second airbag and a dropper connected to each other, one end of the dropper is connected to the second airbag, and the second airbag is connected to the first airbag; By squeezing the first airbag, a pressure difference is generated between the second airbag and the dropper and the outside world to quantitatively absorb the sample in the holding tank. The second airbag is used to store samples exceeding the range of the dropper. The first airbag is squeezed again to make the sample in the dropper drip out.

2. The quantitative sampling device according to claim 1, characterized in that: The first airbag and the second airbag are vertically arranged, and the first airbag is located above the second airbag.

3. The quantitative sampling device according to claim 2, characterized in that: The dropper is connected to an end of the second airbag close to the first airbag.

4. The quantitative sampling device according to claim 1, characterized in that: The dropper comprises: A quantitative part, the quantitative part is vertically arranged, and the end of the quantitative part is a sampling port; A connecting portion having a first port and a second port, wherein the first port is connected to an end of the second airbag close to the first airbag, and the second port is connected to an end of the quantitative portion away from the sampling port; Wherein, the height of the first port is lower than that of the second port.

5. The quantitative sampling device according to claim 4, characterized in that: Before sampling, the quantitative part is used to act as a stirring rod to remove foam and mix the sample in the containing tank evenly.

6. The quantitative sampling device according to claim 1, characterized in that: A connecting pipe is further provided between the first airbag and the second airbag so as to make the first airbag and the second airbag communicate with each other.

7. The quantitative sampling device according to claim 1, characterized in that: The volume of the second air bag is greater than the volume of the dropper; And / or, the volume of the first airbag is not less than the volume of the second airbag.

8. The quantitative sampling device according to claim 1, characterized in that: An opening is provided at one end of the flow guide away from the accommodating groove, and the flow guide is arranged in a trumpet shape; And / or, the guide member has a guide slope, and the guide slope is arranged in a ring shape and is inclined; And / or, a guide groove is also provided on the guide member.

9. The quantitative sampling device according to any one of claims 1 to 8, characterized in that: The outer surface of the dropper is provided with scales; And / or, the volume of the dropper is a preset value, and the preset value ranges from 1 μl to 100 μl.

10. The quantitative sampling device according to any one of claims 1 to 8, characterized in that: The flow guide and the container are integrally formed, and the dropper, the first airbag and the second airbag are integrally formed.

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