Atomizer for high matrix sample detection
By designing aerosol channels that first tapered and then expanded at the tip of the atomizer, the blockage problem in sample detection of high salt and particle content is solved, and more fine aerosol generation and sample detection sensitivity are achieved.
Patent Information
- Application Number
- CN202422040828.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-22
- Publication Date
- 2025-06-24
- Estimated Expiration
- 2034-08-22
AI Technical Summary
Existing concentric atomizers are prone to tip blockage in sample detection with high salt and particle content, resulting in unstable sample injection and affecting mass spectrometry analysis performance and reliability.
A nebulizer for high-matrix sample detection was designed, with aerosol channels formed inside the tip of the nebulizer, and through aerosol channel structure that tapered first and then expanded, ensuring that the gas and the sample fully function to form a finer aerosol, thereby reducing sample blockage.
It achieves finer aerosol production, reduces the risk of sample blockage, is suitable for high-matrix sample detection, and increases the sensitivity of sample detection by about twice.
Smart Images
Figure CN223010837U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of mass spectrometry analysis, in particular to an atomizer for detecting high matrix samples. Background Technique
[0002] In the field of mass spectrometry analysis, the sample introduction system is an important component. As an important part of the sample introduction system, the performance of the atomizer greatly affects the detection of samples. If the velocity of the gas at the outlet of the atomizer is higher than the speed of sound, it will help to generate finer aerosol, thereby improving the analysis performance of the mass spectrometry. In addition, if the inner wall of the atomizer is continuously wetted by a new solution, the atomizer is not easily blocked at the tip. However, the currently used concentric atomizer is often blocked due to high salt content and particles in the sample solution, etc., and stable sample introduction cannot be achieved, which greatly affects the performance and reliability of mass spectrometry analysis. Content of the Utility Model
[0003] To solve the above technical problems, the utility model designs an atomizer for detecting high matrix samples.
[0004] The utility model adopts the following technical scheme:
[0005] An atomizer for detecting high matrix samples, including an atomizer body, the atomizer body is composed of an external gas transmission tube and an internal sample transmission tube, a gas transmission channel is formed between the inside of the gas transmission tube and the sample transmission tube, an air inlet is arranged at the initial end of the gas transmission channel, and an air outlet is arranged at the end. A sample transmission channel is opened in the center of the sample transmission tube, a sample inlet is arranged at the initial end of the sample transmission channel, and a sample outlet is arranged at the end of the sample transmission channel. The air outlet is communicated with the sample outlet. An atomizer tip is arranged at the end of the gas transmission tube, an aerosol channel is formed inside the atomizer tip, and an aerosol outlet is arranged at the end of the atomizer tip. The aerosol channel extends from the end of the sample transmission channel to the aerosol outlet. In the aerosol channel, the gas and the sample fully act to form an aerosol.
[0006] Preferably, the aerosol channel first tapers and then expands, the length of the tapered section is 0.4 - 0.8 mm, the length of the expanded section is 3 - 5 mm, and the expansion angle of the expanded section is 20° - 60°.
[0007] Preferably, the clearance area between the inner diameter of the gas transmission channel and the outer diameter of the sample transmission tube at the place where the aerosol channel is flush with the end of the sample transmission channel is 0.015 - 0.064 mm 2 .
[0008] Preferably, the sample transmission channel tapers from the initial part to the end, and the diameter is 150 - 500 μm.
[0009] Preferably, the gas transmission channel is divided into two parts. One is the vertical part, which extends straight down perpendicular to the direction of the sample transmission channel and has a diameter of 1000 - 2500 μm. The other is the parallel part, which is parallel to the sample transmission channel and surrounds the sample transmission tube. It tapers near the tip of the nebulizer, and the parallel part of the gas transmission channel is concentric with the sample transmission channel.
[0010] Preferably, a support is provided between the gas transmission tube and the sample transmission tube.
[0011] Preferably, multiple groups of supports are axially arranged along the sample transmission direction, with the number of groups being 1 - 4. The number of supports in each group is 1 - 5, and the included angle between adjacent supports is 72° - 360°.
[0012] Preferably, an air inlet connection part is provided at the initial end of the gas transmission tube. The air inlet connection part is connected to the air inlet channel.
[0013] Preferably, a sample injection connection part is provided at the initial end of the sample transmission tube. The connection of the gas transmission channel of the vertical part of the gas transmission channel is as close as possible to the end of the sample injection connection part. The sample injection connection part is directly connected to the sample injection channel without dead volume.
[0014] Preferably, the nebulizer body is integrally formed by 3D printing.
[0015] The beneficial effects of the present utility model are as follows: In the present utility model, an aerosol channel is provided at the gas outlet of the gas transmission channel and the sample outlet of the sample transmission channel. After the aerosol channel first contracts and then expands, an accelerated aerosol is formed. This aerosol channel ensures the generation of a finer aerosol and can also reduce sample blockage, making it suitable for the detection of high - matrix samples; at the same time, the sample detection sensitivity is increased by about twice. Brief Description of the Drawings
[0016] Figure 1 It is a schematic structural diagram of the main view of the nebulizer of the present utility model;
[0017] Figure 2 It is a schematic cross - sectional structural diagram of the nebulizer of the present utility model;
[0018] Figure 3 It is a schematic structural diagram of the right view of the mass spectrometry nebulizer of the present utility model;
[0019] Figure 4 It is a comparison effect diagram of the present utility model and a commercial nebulizer;
[0020] Figure 5 It is a diagram of the actual sample test results of the present utility model and a commercial nebulizer;
[0021] In the figure: 10, gas transmission tube; 11, gas transmission channel; 12, air inlet; 13, air outlet; 14, air inlet connection part; 20, sample transmission tube; 21, sample transmission channel; 22, sample injection port; 23, sample outlet; 24, tapered section of the sample transmission channel; 25, sample injection connection part; 30, atomizer tip; 31, aerosol channel; 32, tapered section; 33, expansion section; 40, support. Detailed implementation mode
[0022] The technical solution of the present utility model will be further specifically described below through specific embodiments in conjunction with the accompanying drawings:
[0023] Embodiment: As Figures 1 - 3 shown, an atomizer for detecting high-matrix samples includes an atomizer main body, which is composed of an external gas transmission tube 10 and an internal sample transmission tube 20. A gas transmission channel 11 is formed between the inside of the gas transmission tube and the sample transmission tube. A sample transmission channel 21 is provided in the center of the sample transmission tube. An atomizer tip 30 is provided at the end of the gas transmission tube. An aerosol channel 31 is formed inside the atomizer tip. An aerosol outlet is provided at the end of the atomizer tip. The aerosol channel extends from the end of the sample transmission channel to the aerosol outlet. Inside the aerosol channel, the gas and the sample fully act to form an aerosol.
[0024] The gas transmission channel includes two parts. One is the vertical part, which is straight down perpendicular to the direction of the sample transmission channel and has a diameter of 1000 - 2500 μm. The other is the parallel part, which is parallel to the sample transmission channel and surrounds the sample transmission tube, and tapers near the atomizer tip. The parallel part of the gas transmission channel is concentric with the sample transmission channel. An air inlet 12 is provided at the initial end of the gas transmission channel, and the air inlet is provided at the upper part of the vertical part. An air outlet 13 is provided at the end of the gas transmission channel.
[0025] An air inlet connection part 14 is provided at the initial end of the gas transmission tube. The air inlet connection part is connected to the air inlet channel. In this embodiment, the carrier gas flow rate is 0 - 1.2 L / min.
[0026] A sample injection port 22 is provided at the initial end of the sample transmission channel, and a sample outlet 23 is provided at the end of the sample transmission channel. The air outlet is communicated with the sample outlet.
[0027] A sample injection connection part 25 is provided at the initial end of the sample transmission tube. The sample injection connection part is connected to the mass spectrometry sample injection connecting tube. The sample enters the sample transmission channel through the connecting tube. The diameter of the sample injection port of the sample transmission channel is slightly larger than that of the sample outlet, and its diameter tapers from the tapered section 24 of the sample transmission channel, and the tapered distance matches the tapered section at the air outlet of the gas transmission channel.
[0028] Generally, the distance of the tapered section of the sample transmission channel is usually set to 0.1 - 2 mm, preferably 0.5 - 1 mm.
[0029] The aerosol channel first gradually contracts and then expands, the length of the gradually contracting section 32 is 0.4-0.8 mm, the length of the expanding section 33 is 3-5 mm, and the expansion angle of the expanding section is 20°-60°.
[0030] In this embodiment, the sample and gas are mixed at the starting position of the aerosol channel, and the aerosol channel first contracts and then expands to form an accelerated aerosol. This aerosol channel ensures the generation of finer aerosols and can also reduce sample clogging, which is suitable for high-matrix sample detection.
[0031] A support 40 is provided between the gas transmission tube and the sample transmission tube. The supports are provided in multiple groups axially along the sample transmission direction, the number of which is 1-4 groups, the number of supports in each group is 1-5, and the angle between adjacent supports is 72°-360°.
[0032] When the utility model is used, the injection connection part is connected to the mass spectrometer injection connection tube, the sample is transmitted through the sample transmission channel, the carrier gas is connected to the mass spectrometer carrier gas connection tube through the gas injection connection part, and is transmitted through the gas transmission channel. Under the action of the carrier gas, the sample forms an aerosol through the aerosol channel and is then ejected.
[0033] In this example, the high-matrix sample atomizer according to the preferred embodiment of the utility model was used to perform experimental operations.
[0034] This example uses an Agilent 8900 ICP-MS and a dual-channel nebulizer that comes standard with the instrument. By analyzing 10 ppb standard solutions containing different elements, standard curves of lead elements at different concentrations, and the test results of actual samples, the test results of the standard nebulizer and the high-matrix sample detection nebulizer of the utility model are compared to further verify the performance of the nebulizer of the utility model.
[0035] In this embodiment, the injection connection part is connected to the Agilent 8900 injection connection tube, and the peristaltic pump provided by the ICP-MS is used to inject the sample at a flow rate of 0.1 rps. The gas inlet connection part is connected to the carrier gas connection tube to introduce the carrier gas, and the sample is injected at the optimal flow rate of 1.1 L / min carrier gas flow rate of the standard nebulizer. Before each test, the parameters of the ICP-MS are tuned to the optimal parameters, and the content of 52Cr, 55Mn, 59Co, 75As, 85Rb, 88Sr, 133Cs, 206Pb, 207Pb, and 208Pb in the standard solutions containing 10ppb of different elements, standard curves of lead elements with different concentrations, and actual samples are measured under the tuned parameters.
[0036] The results of the 10 ppb standard solution are as follows: Figure 4As shown, the response values of the standard solutions of different elements of the atomizer in the present utility model are much higher than those of the standard atomizer. The results show that the sensitivity of the atomizer of the present utility model is better than that of the standard atomizer.
[0037] The determination results of the standard curves of lead elements with different concentrations and the lead element content in the actual samples are as Figure 5 shown. For the lead (Pb) element, the R 2 of the linear fitting of the standard curve is 0.9999, and the R2 of the linear fitting of the standard curve of the standard atomizer is 1. The t-test is performed on the measured values of the standard atomizer and the measured values of the atomizer in the present utility model for the element contents of 52Cr, 55Mn, 59Co, 75As, 85Rb, 88Sr, 133Cs, 206Pb, 207Pb, and 208Pb in the actual samples. The results show that P = 0.275, and there is a significant correlation between the two.
[0038] The above test results show that the atomizer in the present utility model can not only detect the elements in the standard solution with high sensitivity, but also stably detect samples with low to high concentrations, and it has been verified in the application of actual samples, indicating that the atomizer for detecting high-matrix samples proposed in the present utility model has good analytical performance and stability.
[0039] The above-described embodiments are only a preferred solution of the present utility model, and do not impose any form of limitation on the present utility model. There are other variants and modifications without exceeding the technical solutions recorded in the claims.
Claims
1. A nebulizer for high-matrix sample detection, comprising a nebulizer body, the nebulizer body consisting of an external gas transmission tube and an internal sample transmission tube, a gas transmission channel formed between the gas transmission tube and the sample transmission tube, an air inlet is arranged at the initial end of the gas transmission channel, and an air outlet is arranged at the end, a sample transmission channel is opened in the center of the sample transmission tube, an inlet is arranged at the initial end of the sample transmission channel, and an outlet is arranged at the end of the sample transmission channel, and the outlet is connected to the outlet, wherein the gas inlet is connected to the outlet, and the gas inlet ... and the gas inlet A nebulizer tip is arranged at the end of the gas transmission tube, an aerosol channel is formed inside the nebulizer tip, an aerosol outlet is arranged at the end of the nebulizer tip, the aerosol channel extends from the end of the sample transmission channel to the aerosol outlet, and in the aerosol channel, the gas and the sample fully react to form an aerosol.
2. The atomizer for high matrix sample detection according to claim 1, characterized in that: The aerosol channel first gradually contracts and then expands, the length of the gradually contracting section is 0.4-0.8 mm, the length of the expanding section is 3-5 mm, and the expansion angle of the expanding section is 20°-60°.
3. The atomizer for high matrix sample detection according to claim 1, characterized in that: The gap area between the inner diameter of the gas transmission channel and the outer diameter of the sample transmission tube at the point where the aerosol channel and the sample transmission channel are flush is 0.015-0.064 mm 2 .
4. The atomizer for high matrix sample detection according to claim 1, characterized in that: The sample transmission channel tapers from the initial part to the end, and has a diameter of 150-500 μm.
5. The atomizer for high matrix sample detection according to claim 1, characterized in that: The gas transmission channel is divided into two parts, one of which is a vertical part, which is perpendicular to the sample transmission channel and goes straight downward, with a diameter of 1000-2500 μm, and the other is a parallel part, which is parallel to the sample transmission channel and surrounds the sample transmission tube, and gradually shrinks near the tip of the nebulizer. The parallel part of the gas transmission channel is concentric with the sample transmission channel.
6. The atomizer for high matrix sample detection according to claim 1, characterized in that: A support is provided between the gas transmission tube and the sample transmission tube.
7. The atomizer for high matrix sample detection according to claim 6, characterized in that: The supports are arranged in multiple groups axially along the sample transmission direction, the number of which is 1-4 groups, the number of supports in each group is 1-5, and the angle between adjacent supports is 72°-360°.
8. The atomizer for high matrix sample detection according to claim 1, characterized in that: The initial end of the gas transmission pipe is provided with a gas inlet connection portion.
9. The atomizer for high matrix sample detection according to claim 1, characterized in that: The initial end of the sample transmission tube is provided with a sample injection connection portion.
10. The atomizer for high matrix sample detection according to claim 1, characterized in that: The atomizer body is integrally formed by 3D printing.