Multi-layer fine filtration device for producing human interferon alpha2b injection

Abstract

The utility model discloses a multi-layer fine filtration device for producing a human interferon alpha2b injection. The fine filtering device comprises a fine filtering tank and a cleaning structure, the cleaning structure is arranged on the outer wall of the fine filtration tank and is provided with a water pipe welded at one end of the liquid inlet pipe and used for conveying pure water into the fine filtration tank; and the cleaning structure further comprises a filtrate pipe welded on the outer wall of the fine filtration tank for discharging filtrate to remove impurities. According to the utility model, the first valve of the stock solution pipe is closed, the water pipe is used for conveying pure water from the solution inlet pipe to wash impurities, the third valve is opened to quickly discharge filtrate with impurities inside from the filtrate pipe, and the residual pure water inside after cleaning can be quickly discharged to a water tank below the fine filtering tank by opening the third valve; therefore, impurity filtrate is cleaned in a pure water cleaning mode, contact with the outside is avoided in the cleaning process, the probability that the interior of the tank body is polluted by bacteria is reduced, manual cleaning is replaced, and the cleaning effect and the cleaning speed are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of biopreparation production, in particular to a multi-layer fine filtration device for the production of human interferon α2b injection. Background Technique

[0002] Human interferon α2B injection is a biopreparation, usually used to treat viral infections or diseases related to the immune system. Human interferon is a protein produced by human cells, which can help the body fight viral infections and regulate the function of the immune system. When producing human interferon α2b injection, multiple steps are required to obtain it. Generally, the following steps are needed: cell culture, cell harvest, purification, concentration and pH adjustment, sterilization and filtration, filling and packaging, quality control and batch release to obtain a qualified injection;

[0003] Currently, after adjusting the pH value of the purified product, it is necessary to further fine-filter the primary product to ensure that residual microorganisms, large impurities and suspended matters in the injection can be removed, and the purity of the injection is improved. A multi-layer fine filtration device with microporous filtration, deep filtration and surface filtration is used to fine-filter the primary product.

[0004] After long-term use of the filter layer inside the multi-layer fine filtration device for filtration, more impurities will accumulate and remain inside, affecting the filtration effect. Therefore, it is necessary to manually open the tank body of the device to take out the filter layer for cleaning and impurity removal before use. The manual cleaning efficiency is low, affecting the efficiency of the fine filtration process of the injection. During this process, when the tank body is opened, it will come into contact with the external environment and the cleaning personnel, increasing the probability of bacterial contamination inside the tank body, and thus affecting the quality of the produced injection. Therefore, a multi-layer fine filtration device that does not need to open the tank body for efficient cleaning is required for use. Content of the Utility Model

[0005] The purpose of the utility model is to provide a multi-layer fine filtration device for the production of human interferon α2b injection, so as to solve the problems put forward in the above background technique.

[0006] To achieve the above purpose, the utility model provides the following technical scheme: A multi-layer fine filtration device for the production of human interferon α2b injection, comprising: a fine filtration tank and a cleaning structure; the cleaning structure is arranged on the outer wall of the fine filtration tank, and the cleaning structure has a water pipe welded to one end of the liquid inlet pipe to convey pure water into the fine filtration tank; the cleaning structure also includes a filtrate pipe welded to the outer wall of the fine filtration tank to discharge filtrate for impurity removal.

[0007] By adopting the above technical solution, through the transformation of the main body of the fine filtration tank, pure water can be transported from the water pipe into the liquid inlet pipe, so that the pure water enters the fine filtration tank, and the filtrate impurities in the fine filtration tank are discharged from the filtrate pipe, realizing the process of quickly cleaning the internal impurities instead of manual operation, making the cleaning process not in contact with the outside world, reducing the probability of being contaminated by bacteria in the tank body, and thus improving the quality of the produced injection solution.

[0008] Preferably, the cleaning structure includes a liquid inlet pipe welded to the bottom of the fine filtration tank, a stock solution pipe welded to one end of the liquid inlet pipe, a water pipe welded to one end of the liquid inlet pipe, a first valve provided on the main bodies of the stock solution pipe and the water pipe, a second valve provided at the bottom end of the liquid inlet pipe, a filtrate pipe welded to the outer wall of the fine filtration tank, and a third valve provided at one end of the filtrate pipe.

[0009] By adopting the above technical solution, by closing the first valve of the stock solution pipe, pure water is transported from the water pipe through the liquid inlet pipe to wash the impurities, the third valve is opened to quickly discharge the filtrate with impurities inside from the filtrate pipe, and the remaining pure water inside after cleaning can be quickly discharged to the water tank below the fine filtration tank by opening the second valve, so as to realize the function of cleaning the impurity filtrate by using pure water for cleaning, replacing manual cleaning and improving the sanitary conditions and cleaning speed.

[0010] Preferably, a drying structure is provided at the bottom of the fine filtration tank. The drying structure includes a hot air blower bolted to the bottom end of the fine filtration tank, a hot air pipe inserted into the air outlet of the hot air blower, and a fourth valve provided on the main body of the hot air pipe. One end of the hot air pipe is welded to the outer wall of the fine filtration tank and is connected to the inside.

[0011] By adopting the above technical solution, the hot air blower can transport hot air from the hot air pipe with the fourth valve opened into the fine filtration tank to dry the remaining pure water in the tank body, so that the fine filtration tank maintains a dry and clean state for filtering the subsequent injection solution, reducing the influence of the remaining pure water inside on the quality of the produced injection solution.

[0012] Preferably, a tower buckle is provided on the outer wall of the top of the fine filtration tank, a tank cover is connected to the top of the fine filtration tank, the buckle ring of the tower buckle is pressed on the chuck on the outer wall of the tank cover, and a liquid outlet pipe is welded to the top of the tank cover.

[0013] By adopting the above technical solution, by using the tower buckle on the top of the fine filtration tank, the tank cover can be clamped and sealed by the tower buckle, so that a closed space is formed inside, the filtered injection solution is discharged from the liquid outlet pipe and collected to enter the next process, and when the internal filtration structure needs to be replaced, it can be opened for replacement, improving the convenience during the maintenance of the device.

[0014] Preferably, the drying structure further includes an exhaust pipe welded to the top of the tank cover and a sealing cover threadedly connected to the top of the exhaust pipe.

[0015] By adopting the above technical solution, a sealing cover threadedly connected to an exhaust pipe is installed on the top of the tank cover. When a hot air blower is used for drying, the sealing cover is opened and the exhaust pipe is used for exhaust, so that a channel for air flow to flow outward is formed inside. Under the action of wind force and temperature, the evaporation of residual pure water inside can be increased, thereby achieving the effect of quickly drying the inner wall of the fine filter tank.

[0016] Preferably, three filter layers are arranged inside the fine filter tank, and three side tubes extend from one side of the outer wall of the filtrate tube and are welded to the outer wall of the fine filter tank, and the position where the three side tubes are connected to the fine filter tank is below each filter layer.

[0017] By adopting the above technical scheme, by using three layers of filter layers with different filtering methods to perform multiple fine filtration of the injection liquid, the filtration effect can be improved and the quality of the injection liquid produced can be improved. At the same time, three groups of side tubes extending from one side of the filtrate tube are arranged below the filter layer. When pure water is continuously transported to clean internal impurities, the pure water discharge point is close to the discharge port, which will make the water flow speed below the filter layer faster, and the cleaning effect of adsorbed impurities can be improved.

[0018] Preferably, the main body shape of the liquid inlet pipe is a transverse T-shape, and the second valve is located on the liquid inlet pipe in a vertical direction.

[0019] By adopting the above technical solution and designing the main shape of the liquid inlet pipe, the horizontal pipeline is used to transport the injection concentrate and pure water, and the vertical pipeline is used to quickly discharge the pure water remaining after the fine filter tank is cleaned and to discharge the pure water in the horizontal pipeline, thereby reducing the impact of internal pure water residue on the quality of the produced injection.

[0020] Compared with the prior art, the beneficial effects of the utility model are:

[0021] (1) By closing the first valve of the raw liquid pipe, pure water is transported from the liquid inlet pipe to flush impurities, and the third valve is opened to quickly discharge the filtrate with impurities from the filtrate pipe. After cleaning, the remaining pure water inside can be quickly discharged to the sink below the fine filter tank by opening the third valve, thereby achieving the effect of cleaning the impurity filtrate by pure water cleaning, so that the cleaning process does not contact the outside world, reducing the probability of bacterial contamination in the tank, and replacing manual cleaning to improve the cleaning effect and cleaning speed;

[0022] (2) The hot air can be delivered to the fine filter tank from the hot air pipe with the fourth valve opened by the hot air blower. After the sealing cover is opened, the exhaust pipe is used to exhaust the air, so that a channel for air to flow outward is formed inside. Under the action of wind force and temperature, the evaporation of the residual pure water inside can be increased, so as to achieve the effect of quickly drying the inner wall of the fine filter tank, so that the fine filter tank can be kept in a dry and clean state for filtering the injection liquid later, and the influence of the residual pure water inside on the quality of the injection liquid production can be reduced. Brief Description of the Drawings

[0023] Figure 1 This is a schematic diagram of the overall structure of the device of the present utility model;

[0024] Figure 2 This is a sectional view of the overall structure of the device of the present utility model;

[0025] Figure 3 This is a schematic diagram of the drying structure of the present utility model;

[0026] Figure 4 This is a schematic diagram of the tank cover structure of the present utility model;

[0027] Figure 5 This is a sectional view of the filter layer and the filtrate pipe structure of the present utility model.

[0028] In the figure: 1, fine filter tank; 2, cleaning structure; 201, liquid inlet pipe; 202, stock solution pipe; 203, water pipe; 204, first valve; 205, second valve; 206, filtrate pipe; 207, third valve; 3, drying structure; 301, hot air blower; 302, hot air pipe; 303, fourth valve; 304, exhaust pipe; 305, sealing cover; 4, filter layer; 5, tank cover; 6, tower buckle. Detailed Description of the Embodiments

[0029] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0030] The following is a further detailed description of the present utility model in conjunction with the attached Figures 1-5 to further illustrate the present utility model.

[0031] Embodiment 1

[0032] Please refer to Figures 1 to 5, an embodiment provided by the present utility model: a multi-layer fine filtration device for the production of human interferon α2b injection, comprising: a fine filtration tank 1 and a cleaning structure 2. The cleaning structure 2 is arranged on the outer wall of the fine filtration tank 1. The cleaning structure 2 has a water pipe 203 welded to one end of the liquid inlet pipe 201 to convey pure water into the fine filtration tank 1. Pure water can be conveyed into the liquid inlet pipe 201 from the water pipe 203, so that the pure water enters the fine filtration tank 1 to clean impurities. The cleaning structure 2 further includes a filtrate pipe 206 welded to the outer wall of the fine filtration tank 1 to discharge filtrate for impurity removal. The pure water conveyed into the interior carries impurities and is discharged from the filtrate pipe 206, which can form a channel for the flow of pure water, and the flowing pure water continuously carries impurities out until it is cleaned up, realizing the process of quickly cleaning internal impurities instead of manual work, making the cleaning process not in contact with the outside world, reducing the probability of being contaminated by bacteria in the tank body, and thus improving the quality of the produced injection.

[0033] Embodiment Two

[0034] Please refer to Figure 2 and Figure 3 , the cleaning structure 2 includes a liquid inlet pipe 201 welded to the bottom of the fine filtration tank 1, a stock solution pipe 202 welded to one end of the liquid inlet pipe 201, a water pipe 203 originally welded to one end of the liquid inlet pipe 201. One end of the liquid inlet pipe 201 is welded to the bottom of the fine filtration tank 1. The stock solution pipe 202 and the water pipe 203 at the other end can be used to convey the injection stock solution and pure water into the interior. First valves 204 are arranged on the main bodies of the stock solution pipe 202 and the water pipe 203. The same first valves 204 are installed on the main bodies of the stock solution pipe 202 and the water pipe 203, and the first valves 204 at different positions can be closed for operation during filtration and cleaning. A second valve 205 is arranged at the bottom end of the liquid inlet pipe 201. After the device is cleaned, the remaining pure water in the fine filtration tank 1 can be quickly discharged into the water tank below the fine filtration tank 1 by opening the second valve 205. A filtrate pipe 206 is welded to the outer wall of the fine filtration tank 1 and a third valve 207 is arranged at one end of the filtrate pipe 206. By opening the third valve 207, the filtrate with impurities inside can be quickly discharged from the filtrate pipe 206, achieving the formation of a channel for the flow of pure water, and the flowing pure water can carry away impurities for cleaning. A drying structure 3 is arranged at the bottom of the fine filtration tank 1;

[0035] Please refer to Figure 3 and Figure 4, the drying structure 3 includes a hot air blower 301 bolted to the bottom end of the fine filter tank 1. The hot air blower 301 is an existing structure that uses the blown hot air to dry the fine filter tank 1. The model of the hot air blower 301 can be RH-X22-0215. A hot air pipe 302 plugged into the air outlet of the hot air blower 301 and a fourth valve 303 provided on the main body of the hot air pipe 302. The installation of the fourth valve 303 is to close the passage of the hot air pipe 302 and open it when ventilation is required, to prevent the raw liquid from flowing into the hot air pipe 302 during filtration and damaging the hot air blower 301. One end of the hot air pipe 302 is welded to the outer wall of the fine filter tank 1 and is in communication with the inside. The above structure can dry the inside of the fine filter tank 1, so that the filtered injection liquid is in a dry and clean state, reducing the influence of the remaining pure water inside on the quality of the produced injection liquid. A tower buckle 6 is provided on the outer wall of the top of the fine filter tank 1. A tank cover 5 is connected to the top of the fine filter tank 1. The buckle of the tower buckle 6 is pressed against the chuck on the outer wall of the tank cover 5. A liquid outlet pipe 7 is welded to the top of the tank cover 5. By using the tower buckle 6 at the top of the fine filter tank 1, the tank cover 5 can be clamped and sealed, forming a closed space inside. The filtered injection liquid is discharged from the liquid outlet pipe 7 and collected for the next process. When the internal filtering structure needs to be replaced, it can be opened for replacement, improving the convenience of device maintenance.

[0036] Embodiment Three

[0037] Please refer to Figures 1 to 5, the drying structure 3 further includes an exhaust pipe 304 welded to the top of the tank cover 5 and a sealing cover 305 threadedly connected to the top of the exhaust pipe 304. By installing a sealing cover 305 threadedly connected to the exhaust pipe 304 on the top of the tank cover 5, when using the hot air blower 301 for drying, the sealing cover 305 is opened and the exhaust pipe 304 is used for exhausting, so as to form a channel for the internal airflow to flow outwards. Under the action of wind force and temperature, the evaporation of the remaining pure water inside can be improved, achieving the effect of quickly drying the inner wall of the fine filter tank 1. There are three filter layers 4 arranged inside the fine filter tank 1. On one side of the outer wall of the filtrate pipe 206, there are three side pipes extending out and welded to the outer wall of the fine filter tank 1, and the positions where the three side pipes are connected to the fine filter tank 1 are below each filter layer 4. By using the filter layer 4 with three different filtering methods to perform multiple fine filtrations on the injection solution, the filtering effect can be improved, and the quality of the produced injection solution can be improved. At the same time, the three side pipes extending from one side of the filtrate pipe 206 are arranged below the filter layer 4. When continuously transporting pure water to clean the internal impurities, the pure water discharge point is close to the discharge port, which will make the water flow rate below the filter layer 4 faster, and the cleaning effect on the adsorbed impurities can be improved. The main shape of the liquid inlet pipe 201 is a horizontal T shape, and the second valve 205 is located on the vertical liquid inlet pipe 201. Through the design of the main shape of the liquid inlet pipe 201, the horizontal pipe is used to transport the injection solution stock solution and pure water, and the vertical direction is used to quickly discharge the remaining pure water in the fine filter tank 1 after cleaning and discharge the pure water in the horizontal pipe, reducing the influence of the remaining pure water inside on the quality of the produced injection solution.

[0038] Working principle: When cleaning impurities, the first valve 204 of the stock solution pipe 202 is closed, the first valve 204 of the water pipe 203 and the three third valves 207 are opened, and pure water is transported from the water pipe 203 to the liquid inlet pipe 201 and enters the fine filter tank 1. After the pure water enters, the internal mixed filtrate will be discharged from the filtrate pipe 206, forming a pure water flow channel. When the pure water flows, it will carry the impurities and the remaining injection solution out together. After transporting pure water for a period of time, the internal impurities will be taken away completely, leaving only a small amount of pure water at the bottom of the tank. At this time, the second valve 205 is opened to discharge the pure water. Then, the first valve 204 and the third valve 207 are closed, and the fourth valve 303 is opened. The hot air blower 301 of the drying structure 3 is used to blow hot air towards the fine filter tank 1 for drying.

[0039] For those skilled in the art, it is obvious that the present utility model is not limited to the details of the above exemplary embodiments, and without departing from the spirit or basic characteristics of the present utility model, the present utility model can be implemented in other specific forms.

Claims

1. A multi-layer fine filtration device for the production of human interferon α2b injection, characterized in that: include: Fine filter tank (1); A cleaning structure (2), the cleaning structure (2) being arranged on the outer wall of the fine filter tank (1), the cleaning structure (2) comprising a water pipe (203) welded to one end of the liquid inlet pipe (201) for conveying pure water into the fine filter tank (1); The cleaning structure (2) also includes a filtrate pipe (206) welded to the outer wall of the fine filter tank (1) for discharging the filtrate to remove impurities; The cleaning structure (2) comprises a liquid inlet pipe (201) welded to the bottom of the fine filter tank (1), a raw liquid pipe (202) welded to one end of the liquid inlet pipe (201), a water pipe (203) welded to one end of the liquid inlet pipe (201), a first valve (204) arranged on the raw liquid pipe (202) and the main body of the water pipe (203), a second valve (205) arranged at the bottom end of the liquid inlet pipe (201), a filtrate pipe (206) welded to the outer wall of the fine filter tank (1), and a third valve (207) arranged at one end of the filtrate pipe (206).

2. The multi-layer fine filtration device for producing human interferon α2b injection according to claim 1, characterized in that: A drying structure (3) is provided at the bottom of the fine filter tank (1), the drying structure (3) comprising a hot air blower (301) connected to the bottom end of the fine filter tank (1) by bolts, a hot air pipe (302) plugged into the air outlet of the hot air blower (301), and a fourth valve (303) provided on the main body of the hot air pipe (302), one end of the hot air pipe (302) being welded to the outer wall of the fine filter tank (1) and communicating with the interior.

3. The multi-layer fine filtration device for producing human interferon α2b injection according to claim 2, characterized in that: The top outer wall of the fine filter tank (1) is provided with a tower buckle (6), the top cover of the fine filter tank (1) is connected to a tank cover (5), the buckle ring of the tower buckle (6) is crimped onto a clamping head on the outer wall of the tank cover (5), and a liquid outlet pipe (7) is welded to the top of the tank cover (5).

4. A multi-layer fine filtration device for producing human interferon α2b injection according to claim 2 or 3, characterized in that: The drying structure (3) further comprises an exhaust pipe (304) welded to the top of the tank cover (5) and a sealing cover (305) threadedly connected to the top of the exhaust pipe (304).

5. The multi-layer fine filtration device for producing human interferon α2b injection according to claim 1, characterized in that: The fine filter tank (1) is provided with three filter layers (4) inside, and three side tubes extend from one side of the outer wall of the filtrate tube (206) and are welded to the outer wall of the fine filter tank (1), and the position where the three side tubes are connected to the fine filter tank (1) is below each filter layer (4).

6. The multi-layer fine filtration device for producing human interferon α2b injection according to claim 1, characterized in that: The main body of the liquid inlet pipe (201) is in a transverse T-shape, and the second valve (205) is located on the liquid inlet pipe (201) in a vertical direction.

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