Microfluidic analyzer
By using a simplified cam drive structure in the hoisting mechanism of the microfluidic analyzer, the problems of complexity and high cost of the hoisting mechanism in the prior art are solved, and the effects of simple structure, high reliability and low cost are achieved.
Patent Information
- Application Number
- CN202421846846.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-31
- Publication Date
- 2025-07-01
- Estimated Expiration
- 2034-07-31
AI Technical Summary
The existing microfluidic analyzer has complex structure, low reliability and high cost.
A simplified hoisting mechanism is designed to directly drive the hoisting and pusher movement by providing the first and second tracks on the cam, reducing the number of components and structural complexity.
The structure simplification and reliability of the hoisting mechanism are achieved, reducing costs, and ensuring efficient operation of the equipment.
Smart Images
Figure CN223042744U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of medical devices, in particular to a microfluidic analyzer. Background Art
[0002] Microfluidic technology is a technology that uses microchannels to process and manipulate tiny fluids. It can integrate basic units such as sample preparation, reaction, separation, and detection in the fields of biology, chemistry, medicine, etc. onto a microfluidic analyzer at the micron scale, and automatically complete the entire analysis process through the microfluidic analyzer, which has a wide range of applications in the field of in vitro diagnosis.
[0003] A dilution liquid sac is preset inside the microfluidic disc, and a dilution liquid for diluting samples is loaded inside the dilution liquid sac. The cover plate of the microfluidic disc is provided with a puncture structure. The existing microfluidic analyzer is provided with a lifting mechanism, which lifts the dilution liquid sac inside the microfluidic disc to the puncture structure of the cover plate during the use of the microfluidic analyzer, and the puncture structure pierces the dilution liquid sac to release the dilution liquid.
[0004] The existing lifting mechanism of the microfluidic analyzer has a complex structure, low reliability, and high cost. Summary of the Utility Model
[0005] In view of this, the utility model provides a microfluidic analyzer.
[0006] The microfluidic analyzer provided in the first aspect of the utility model includes:
[0007] A microfluidic disc, including a disc body, a dilution liquid sac, and a cover plate. The disc body includes a first surface, and the first surface is provided with a microgroove structure and a receiving groove. The dilution liquid sac is received in the receiving groove. The cover plate is connected to the disc body and covers the first surface. A puncture structure is provided at a position on the side of the cover plate facing the dilution liquid sac and opposite to the dilution liquid sac. An opening communicating with the receiving groove is provided at the bottom wall of the receiving groove;
[0008] A rotary drive mechanism, including a turntable and a first driving member. The turntable is used to carry the microfluidic disc. The turntable is provided with a through hole. When the microfluidic disc is placed on the turntable, the through hole is opposite to the opening. The first driving member is used to drive the turntable to rotate;
[0009] The jacking mechanism includes a jacking rod assembly, a cam, and a second driving member. The jacking rod assembly includes a jacking rod, a clamping member, and a push rod. The clamping member is movably installed on the jacking rod in the radial direction. The push rod is movably inserted through the jacking rod. The push rod is used to drive the clamping member to extend out of the outer side of the jacking rod or retract into the interior of the jacking rod. The cam is provided with a first track and a second track. The bottom end of the jacking rod abuts against the first track. The bottom end of the push rod abuts against the second track. The second driving member is used to drive the cam to rotate, so as to drive the jacking rod to pass through the through hole and the opening hole to push the diluent sac towards the puncture structure, and drive the clamping member to extend out of the outer side of the jacking rod to be clamped on the bottom wall of the groove.
[0010] The microfluidic analyzer proposed in the second aspect of the present invention includes:
[0011] A rotation driving mechanism includes a turntable and a first driving member. The turntable is used to carry a microfluidic disk. The turntable is provided with a through hole. When the microfluidic disk is placed on the turntable, the through hole is opposite to the opening hole in the bottom wall of the accommodating groove of the microfluidic disk that accommodates the diluent sac. The first driving member is used to drive the turntable to rotate;
[0012] The jacking mechanism includes a jacking rod assembly, a cam, and a second driving member. The jacking rod assembly includes a jacking rod, a clamping member, and a push rod. The clamping member is movably installed on the jacking rod in the radial direction. The push rod is movably inserted through the jacking rod. The jacking rod is used to drive the clamping member to extend out of the outer side of the jacking rod or retract into the interior of the jacking rod. The cam is provided with a first track and a second track. The bottom end of the jacking rod abuts against the first track. The bottom end of the push rod abuts against the second track. The second driving member is used to drive the cam to rotate. The second driving member is used to drive the cam to rotate, so as to drive the jacking rod to pass through the through hole and the opening hole to push the diluent sac towards the puncture structure of the microfluidic disk, and drive the clamping member to extend out of the outer side of the jacking rod to be clamped on the bottom wall of the groove.
[0013] As can be seen from the above technical solutions, in the microfluidic analyzer proposed in the first aspect of the present invention, by providing a first track and a second track on the cam, the cam directly drives the jacking rod and the push rod to move through the first track and the second track. The jacking mechanism has few components and a simple structure, which can effectively reduce costs and has high operation reliability. Description of the Drawings
[0014] To more clearly illustrate the technical solutions of the embodiments of the present utility model, the following will briefly introduce the drawings required for use in the description of the embodiments. Obviously, the drawings in the following description are some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained according to these drawings.
[0015] Figure 1 is a schematic structural diagram of a microfluidic analyzer proposed in an embodiment of the present utility model;
[0016] Figure 2 is a schematic partial structural diagram of a microfluidic analyzer proposed in an embodiment of the present utility model;
[0017] Figure 3 is Figure 2 an exploded schematic diagram of the structure shown;
[0018] Figure 4 is an exploded schematic diagram of a microfluidic disc proposed in an embodiment of the present utility model;
[0019] Figure 5 is a schematic structural diagram of a disc body from a first perspective proposed in an embodiment of the present utility model;
[0020] Figure 6 is a schematic structural diagram of a disc body from a second perspective proposed in an embodiment of the present utility model;
[0021] Figure 7 is a schematic cross-sectional view of a lifting assembly proposed in an embodiment of the present utility model;
[0022] Figure 8 is a schematic structural diagram of a cam proposed in an embodiment of the present utility model;
[0023] Figure 9 is a schematic structural diagram of a turntable proposed in an embodiment of the present utility model. Detailed implementation manners
[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the drawings in the embodiments of the present utility model. Obviously, the described embodiments are some, but not all, of the embodiments of the present utility model. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present utility model.
[0025] As Figures 1 to 8 shown, an embodiment of the present utility model proposes a microfluidic analyzer 1000, and the proposed microfluidic analyzer 1000 includes a microfluidic disc 100, a rotation driving mechanism 200, and a lifting mechanism 300.
[0026] The microfluidic disk 100 includes a disk body 10, a diluent sac 20, and a cover plate 30. The disk body 10 includes a first surface A. The first surface A is provided with a microgroove structure 40 and a receiving groove E. The diluent sac 20 is received in the receiving groove E. The cover plate 30 is connected to the disk body 10 and covers the first surface A. A puncture structure 31 is provided at a position on the side of the cover plate 30 facing the diluent sac 20 and opposite to the diluent sac 20. An opening E2 communicating with the receiving groove E is provided on the bottom wall E1 of the receiving groove E.
[0027] The rotation driving mechanism 200 includes a turntable 50 and a first driving member 60. The turntable 50 is used to carry the microfluidic disk 100. The turntable 50 is provided with a through hole 51. When the microfluidic disk 100 is placed on the turntable 50, the through hole 51 is opposite to the opening E2. The first driving member 60 is used to drive the turntable 50 to rotate.
[0028] The lifting mechanism 300 includes a push rod assembly 70, a cam 80, and a second driving member 90. The push rod assembly 70 includes a push rod 71, a buckle member 72, and a push rod 73. The buckle member 72 is movably installed on the push rod 71 in the radial direction. The push rod 73 is movably inserted through the push rod 71. The push rod 73 is used to drive the buckle member 72 to extend out of the outside of the push rod 71 or retract into the inside of the push rod 71. The cam 80 is provided with a first track 81 and a second track 82. The bottom end of the push rod 71 abuts against the first track 81. The bottom end of the push rod 73 abuts against the second track 82. The second driving member 90 is used to drive the cam 80 to rotate, so as to drive the push rod 71 to pass through the through hole 51 and the opening E2 to push the diluent sac 20 towards the puncture structure 31, and to drive the buckle member 72 to extend out of the outside of the push rod 71 to be clamped on the bottom wall E1.
[0029] When the proposed microfluidic analyzer 1000 is in use, the microfluidic disk 100 is placed on the turntable 50. The second driving member 90 drives the cam 80 to rotate. The cam 80 drives the push rod 71 and the push rod 73 to rise. The buckle member 72 retracts into the inside of the push rod 71 under the drive of the push rod 73. The push rod 71 extends into the receiving groove E from the opening E2 on the bottom wall E1 of the receiving groove E of the microfluidic disk 100 under the drive of the cam 80. The push rod 71 pushes the diluent sac 20 towards the puncture structure 31 provided on the cover plate 30. The puncture structure 31 pierces the diluent sac 20, and the diluent inside the diluent sac 20 flows out. When the microfluidic disk 100 rotates, under the action of centrifugal force, the diluent flows to the microgroove structure 40 of the disk body 10 to be mixed with the sample liquid. The cam 80 continues to rotate, driving the push rod 71 and the push rod 73 to descend. The buckle member 72 extends out of the outside of the push rod 71 under the drive of the push rod 73. The push rod 71 descends until the buckle member 72 is clamped on the bottom wall E1 of the receiving groove E.
[0030] The microfluidic analyzer 1000 proposed in the embodiments of the present utility model directly drives the ejector rod 71 and the push rod 73 to move through the first track 81 and the second track 82 provided on the cam 80. The lifting mechanism 300 has few components and a simple structure, which can effectively reduce costs and has high operating reliability.
[0031] As Figure 7 shown, the snap member 72 can be but is not limited to a ball. The first driving member 60 and the second driving member 90 can be but is not limited to a motor.
[0032] As Figure 3 shown, in some embodiments, the turntable 50 can be the rotor of a motor, which can play a role in simplifying the structure. Of course, the turntable 50 is not limited to being set as the rotor of a motor. In some other embodiments, the turntable 50 can also be a separate component and is driven to rotate by a motor.
[0033] As Figure 5 and Figure 6 shown, in some embodiments, the microgroove structure 40 includes a sample quantification groove 41, a diluent quantification groove 42, a mixing groove 43, and a colorimetric groove 44. The sample quantification groove 41 and the diluent quantification groove 42 are communicated with the mixing groove 43 so that the sample liquid in the sample quantification groove 41 and the diluent in the diluent quantification groove 42 can flow into the mixing groove 43 for mixing. The mixing groove 43 is communicated with the colorimetric groove 44 so that the mixed liquid in the mixing groove 43 can flow into the colorimetric groove 44 for detection.
[0034] As Figure 5 and Figure 6 shown, in some embodiments, the microgroove structure 40 further includes a sample injection groove 45, a sample remaining groove 46, a diluent injection groove 47, and a diluent remaining groove 48. The sample injection groove 45 is used for injecting the sample liquid. Part of the sample liquid in the sample injection groove 45 flows into the sample quantification groove 41, and the excess sample liquid in the sample injection groove 45 flows into the sample remaining groove 46. The diluent injection groove 47 is used for injecting the diluent. Part of the diluent in the diluent injection groove 47 flows into the diluent quantification groove 42, and the excess diluent in the diluent injection groove 47 flows into the diluent remaining groove 48.
[0035] In some embodiments, a sample addition hole (not shown in the figure) is provided on the cover plate 20, and the sample liquid enters the sample injection groove 45 from the sample addition hole. For example, in some embodiments, a syringe or other tool can be used to inject the sample liquid into the sample injection groove 45 through the sample addition hole.
[0036] As Figure 5 and Figure 6As shown, in some embodiments, the micro-groove structure 40 further includes an arc-shaped flow channel 49. The arc-shaped flow channel 49 communicates with the mixing tank 43 and the colorimetric tank 44. The mixed liquid in the mixing tank 43 flows through the arc-shaped channel into the colorimetric tank 44.
[0037] As Figure 5 and Figure 6 shown, in some embodiments, the micro-groove structure 40 further includes a first capillary flow channel 40a, a second capillary flow channel 40b, and a third capillary flow channel 40c. The first capillary flow channel 40a is connected to the sample quantification tank 41 and the mixing tank 43. The sample liquid in the sample quantification tank 41 flows into the mixing tank 43 through the first capillary flow channel 40a. The second capillary flow channel 40b is connected to the diluent quantification tank 42 and the mixing tank 43. The diluent in the diluent quantification tank 42 flows into the mixing tank 43 through the second capillary flow channel 40b. The third capillary flow channel 40c is connected to the mixing tank 43 and the arc-shaped flow channel 49. After the sample liquid and the diluent are mixed in the mixing tank 43 to form a mixed liquid, the mixed liquid flows into the arc-shaped flow channel 49 through the third capillary flow channel 40c. This setting uses capillary force to drive the liquid flow, and finally forms a siphon effect, cooperating with the external centrifugal force to make the liquid flow into the corresponding tank to realize the quantification of the sample liquid, diluent, and mixed liquid.
[0038] As Figure 5 and Figure 6 shown, in some embodiments, the micro-groove structure 40 further includes a first air vent 40d. When the sample liquid flows into the sample quantification tank 41 and the sample surplus tank 46, the gas in the sample quantification tank 41 and the sample surplus tank 46 can be discharged in time from the first air vent 40d. When the diluent flows into the diluent quantification tank 42 and the diluent surplus tank 48, the gas in the diluent quantification tank 42 and the diluent surplus tank 48 can also be discharged in time from the first air vent 40d, avoiding the influence of the internal air pressure on the liquid inflow.
[0039] As Figure 5 and Figure 6 shown, in some embodiments, the micro-groove structure 40 further includes a second air vent 40e communicating with the mixing tank 43. When the sample liquid and the diluent enter the mixing tank 43, the gas in the mixing tank 43 is discharged in time from the second air vent 40e, avoiding the influence of the internal air pressure on the liquid inflow.
[0040] As Figure 5 and Figure 6 shown, in some embodiments, the micro-groove structure 40 further includes a third air vent 40f communicating with the sample injection tank 45. When the sample liquid flows into the sample injection tank 45, the gas in the sample injection tank 45 is discharged in time from the third air vent 40f, avoiding the influence of the internal air pressure on the liquid injection.
[0041] In some embodiments, the disc body 10 is a disc, and the center of the disc body 10 is the center of the disc.
[0042] As Figure 8 shown, in some embodiments, the strokes of the first track 81 and the second track 82 are different. The "different strokes of the first track 81 and the second track 82" is specifically characterized in that when the cam 80 rotates, the distances that the ejector rod 71 and the push rod 73 rise and fall are different.
[0043] As Figure 8 shown, in some embodiments, the cam 80 includes a first cam portion 83 and a second cam portion 84 stacked with the first cam portion 83. The outer peripheral surface of the first cam portion 83 is the first track 81, and the outer peripheral surface of the second cam portion 84 is the second track 82. At least one of the first cam portion 83 and the second cam portion 84 is eccentrically arranged. In this embodiment, it is easy to machine the first track 81 and the second track 82 with different strokes on the cam 80, reducing the manufacturing cost. It can be understood that by eccentrically arranging one of the first cam portion 83 and the second cam portion 84, it is easier to achieve the first track 81 and the second track 82 with different strokes.
[0044] As Figure 7 shown, in some embodiments, a mating hole 711 is provided on the outer sidewall of the ejector rod 71. The snap member 72 can be movably embedded in the mating hole 711. A mating groove 731 is provided on the outer sidewall of the push rod 73. The push rod 73 has a first position and a second position under the drive of the second track 82. In the first position, the outer sidewall of the push rod 73 is opposite to the mating hole 711, and the snap member 72 extends out of the outer side of the ejector rod 71 due to the abutment of the outer sidewall of the push rod 73. In the second position, the mating groove 731 is opposite to the mating hole 711, and the snap member 72 retracts into the interior of the ejector rod 71 and is embedded in the mating groove 731.
[0045] Specifically, the diameter of the opening E2 in the bottom wall E1 of the groove is adapted to the diameter of the ejector rod 71. Before the ejector rod 71 passes through the opening E2 in the bottom wall E1 of the groove, the push rod 73 moves to the second position, and the mating groove 731 is opposite to the mating hole 711. During the process of the ejector rod 71 passing through the opening E2 in the bottom wall E1 of the groove, the bottom wall E1 of the groove squeezes the snap member 72, causing the snap member 72 to retract into the interior of the ejector rod 71 and be embedded in the mating groove 731.
[0046] As Figure 3 shown, in some embodiments, the microfluidic analyzer 1000 further includes a tension member 400 for generating tension. When the snap member 72 extends out of the outer side of the ejector rod 71 and is clamped to the bottom wall E1 of the groove, the tension pulls the ejector rod 71 in the direction of the cam 80 to press the bottom wall E1 against the turntable 50. In this embodiment, the friction between the microfluidic disk 100 and the turntable 50 can be increased, so that the microfluidic disk 100 can rotate smoothly following the turntable 50.
[0047] AsFigure 3 As shown, in some embodiments, the tension member 400 includes a spring. An abutting portion is provided on the outer sidewall of the ejector rod 71. The spring is sleeved on the ejector rod 71. One end of the spring abuts against the rotary drive mechanism 200, and the other end of the spring abuts against the abutting portion. Of course, the tension member 400 is not limited to a spring and may be a spring sheet or other components capable of providing an elastic force. The spring may be, but is not limited to, a compression spring.
[0048] It should be noted that the tension member 400 is not limited to pulling the ejector rod 71 toward the cam 80 by the action of elastic force. For example, in some other embodiments, the tension member 400 may also pull the ejector rod 71 toward the cam 80 by means of magnetic force, which can be determined according to actual design requirements.
[0049] In some embodiments, the lifting mechanism 300 further includes a support member (not shown in the figure). The cam 80 is disposed between the second drive member 90 and the support member. The cam 80 is rotatably connected to the support member, and the support member is used to support the cam 80. The second drive member 90 may be, but is not limited to, a motor. In this embodiment, by providing the support member to support the cam 80, the force on the cam 80 can be balanced, enabling the cam 80 to rotate smoothly, and at the same time, the force on the second drive member 90 can be reduced.
[0050] As Figure 9 shown, in some embodiments, one side of the turntable 50 for supporting the microfluidic disk 100 includes a guiding surface 52 and a supporting surface 53. The supporting surface 53 is used to support the microfluidic disk 100. The guiding surface 52 surrounds the supporting surface 53, and the guiding surface 52 is inclined with respect to the rotation center line of the turntable 50. Among them, the guiding surface 52 is used to guide the microfluidic disk 100 during the process of moving the microfluidic disk 100 to the turntable 50, and lift the microfluidic disk 100 onto the supporting surface 53 of the turntable 50 during the guiding process.
[0051] As Figure 4 and Figure 9 shown, in some embodiments, a first positioning portion 101 is provided at the bottom of the microfluidic disk 100, and a second positioning portion 54 is provided on the supporting surface 53 of the turntable 50. The second positioning portion 54 is used to cooperate with the first positioning portion 101 to position and install the microfluidic disk 100 on the turntable 50. In this embodiment, through the positioning function of the first positioning portion 101 and the second positioning portion 54, when the microfluidic disk 100 is placed on the supporting surface 53 of the turntable 50, the opening E2 of the bottom wall E1 of the accommodating groove E of the microfluidic disk 100 can be accurately aligned with the through hole 51 of the turntable 50.
[0052] As Figure 4 and Figure 9As shown, in some embodiments, the first positioning portion 101 is an annular portion provided at the bottom of the microfluidic disk 100, and the second positioning portion 54 is an annular groove provided on the supporting surface 53 of the turntable 50.
[0053] As Figures 1 to 3 shown, in some embodiments, the microfluidic analyzer 1000 further includes a housing assembly 500 and a door assembly 600. The rotation driving mechanism 200 and the lifting mechanism 300 are disposed inside the housing assembly 500. The housing assembly 500 is provided with a window 510 communicating with the inside of the housing assembly 500. The door assembly 600 is slidably disposed at the window 510. The door assembly 600 is provided with a placement position 610 for placing the microfluidic disk 100. The door assembly 600 has an open position and a closed position. In the open position, the placement position 610 is exposed outside the housing assembly 500. In the closed position, the placement position 610 is located above the turntable 50.
[0054] During actual use, when it is necessary to place the microfluidic disk 100 into the microfluidic analyzer 1000, the user can manually pull out the door assembly 600 or click on the screen assembly of the microfluidic analyzer 1000, and the door assembly 600 automatically moves out of the housing assembly 500. Then the user places the microfluidic disk 100 at the placement position 610 of the door assembly 600, and then closes the door assembly 600. The microfluidic disk 100 is driven by the door assembly 600 to move onto the turntable 50.
[0055] As Figure 3 and Figure 4 shown, in some embodiments, the disk body 10 includes a disk portion 11 and a column portion 12 provided at the bottom of the disk portion 11. The door assembly 600 is provided with a disk placement opening 620 to form the placement position 610. When the microfluidic disk 100 is placed at the placement position 610, the column portion 12 is inserted into the disk placement opening 620. The diameter of the disk placement opening 620 is larger than the diameter of the column portion 12. Since the microfluidic disk 100 needs to rotate during the mixing process of the sample and the diluent, in this embodiment, by setting the diameter of the disk placement opening 620 to be larger than the diameter of the column portion 12, the microfluidic disk 100 will not contact the inner sidewall of the disk placement opening 620 when rotating, which can not only make the microfluidic disk 100 rotate smoothly, but also reduce the occurrence of noise and improve the user experience.
[0056] In one embodiment, the column portion 12 is the above-mentioned first positioning portion 101.
[0057] As Figure 6As shown, in some embodiments, the disc body 10 further includes a plurality of protruding portions 13. The plurality of protruding portions 13 are arranged at intervals around the opening E2 on the bottom wall E1 of the accommodating groove E. A recessed portion 14 for engaging with the buckle member 72 is formed between two adjacent protruding portions 13. In this embodiment, after the buckle member 72 easily falls into the recessed portion 14 between two adjacent protruding portions 13, during the rotation of the microfluidic disc 100 and the ejector rod 71 assembly 70, relative slippage between the microfluidic disc 100 and the ejector rod 71 assembly 70 can be avoided, the occurrence of noise can be reduced, and the user experience can be improved. Moreover, by arranging the recessed portion 14 on the bottom wall E1 of the accommodating groove E, in this way, during the downward movement of the ejector rod 71 assembly 70, it easily falls into the recessed portion 14 between two adjacent protruding portions 13.
[0058] In some embodiments, the cross-sectional profile of the protruding portion 13 is triangular. The inclined surface of the triangle has a guiding effect, which can guide the buckle member 72 to fall into the recessed portion 14 between two adjacent protruding portions 13.
[0059] As Figure 2 and Figure 3 As shown, in some embodiments, the microfluidic analyzer 1000 further includes a temperature control member 700. The temperature control member 700 is connected to the rotation driving mechanism 200. The temperature control member 700 and the rotation driving mechanism 200 enclose a processing chamber and an opening communicating with the processing chamber. The turntable 50 is located in the processing chamber, and the microfluidic disc 100 enters the processing chamber through the opening. The temperature control member 700 is used to perform heat preservation treatment on the microfluidic disc 100 to avoid the influence of temperature on the analysis result of the sample.
[0060] The specific usage process of the proposed microfluidic analyzer 1000 is as follows: The user opens the door assembly 600, places the microfluidic disc 100 on the placement position 610 of the door assembly 600, and then closes the door assembly 600. During the process of closing the door assembly 600, the microfluidic disc 100 is driven by the door assembly 600 to move to the guiding surface 52 of the turntable 50. Under the guidance of the guiding surface 52, the microfluidic disc 100 is lifted to the supporting surface 53 of the turntable 50. The annular portion at the bottom of the microfluidic disc 100 is embedded in the annular groove provided on the supporting surface 53 of the turntable 50, and the microfluidic disc 100 is installed in place on the turntable 50. Then, the second driving member 90 drives the cam 80 to rotate, and the cam 80 drives the ejector rod 71 and the push rod 73 to rise. The buckle member 72 is driven by the push rod 73 to retract into the interior of the ejector rod 71. The ejector rod 71 extends into the accommodation groove E through the opening E2 on the bottom wall E1 of the accommodation groove E of the microfluidic disc 100 under the drive of the cam 80. The ejector rod 71 pushes the dilution liquid sac 20 towards the puncture structure 31 provided on the cover plate 30, and the puncture structure 31 punctures the dilution liquid sac 20, and the dilution liquid inside the dilution liquid sac 20 flows out. The cam 80 continues to rotate, driving the ejector rod 71 and the push rod 73 to descend. The buckle member 72 is driven by the push rod 73 to extend outside the ejector rod 71, and the ejector rod 71 descends until the buckle member 72 is clamped on the bottom wall E1 of the accommodation groove E to press the bottom wall E1 against the turntable 50. Then, the first driving member 60 drives the turntable 50 to rotate, and the rotating turntable 50 drives the microfluidic disc 100 to rotate. Under the action of centrifugal force, the dilution liquid flows to the micro-groove structure 40 of the disc body 10 and mixes with the sample liquid. After the detection is completed, the cam 80 continues to rotate, driving the ejector rod 71 and the push rod 73 to descend. The buckle member 72 is driven by the push rod 73 to retract into the interior of the ejector rod 71. The ejector rod 71 descends and is pulled out from the opening E2 on the bottom wall E1 of the accommodation groove E of the microfluidic disc 100. The user opens the door assembly 600, and then the microfluidic disc 100 can be removed.
[0061] Such as Figures 1 to 9As shown in the figure, an embodiment of the present utility model also provides a microfluidic analyzer 1000. The provided microfluidic analyzer 1000 includes a rotation driving mechanism 200 and a lifting mechanism 300. The rotation driving mechanism 200 includes a turntable 50 and a first driving member 60. The turntable 50 is used to carry the microfluidic disk 100. The turntable 50 is provided with a through hole 51. When the microfluidic disk 100 is placed on the turntable 50, the through hole 51 is opposite to the opening E2 of the bottom wall E1 of the accommodating groove E that accommodates the dilution liquid sac 20 of the microfluidic disk 100. The first driving member 60 is used to drive the turntable 50 to rotate. The lifting mechanism 300 includes a ejector rod 71 assembly 70, a cam 80 and a second driving member 90. The ejector rod 71 assembly 70 includes an ejector rod 71, a snap member 72 and a push rod 73. The snap member 72 is movably installed on the ejector rod 71 in the radial direction. The push rod 73 is movably inserted through the ejector rod 71. The ejector rod 71 is used to drive the snap member 72 to extend outside the ejector rod 71 or retract inside the ejector rod 71. The cam 80 is provided with a first track 81 and a second track 82. The bottom end of the ejector rod 71 abuts against the first track 81. The bottom end of the push rod 73 abuts against the second track 82. The second driving member 90 is used to drive the cam 80 to rotate, so as to drive the ejector rod 71 to pass through the through hole 51 and the opening E2 to push the dilution liquid sac 20 towards the puncture structure 31 of the microfluidic disk 100, and drive the snap member 72 to extend outside the ejector rod 71 to be clamped on the bottom wall E1.
[0062] For the microfluidic analyzer 1000 provided in this embodiment, by providing the first track 81 and the second track 82 on the cam 80, the cam 80 directly drives the movement of the ejector rod 71 and the push rod 73 through the first track 81 and the second track 82. The components of the lifting mechanism 300 are few and the structure is simple, which can effectively reduce the cost and has high operation reliability.
[0063] For the structures, connection relationships, extended descriptions and beneficial effects of other components of the microfluidic analyzer 1000 provided in this embodiment, reference can be made to the above embodiments and will not be elaborated here.
[0064] The above is only the specific implementation manner of the present utility model, but the protection scope of the present utility model is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present utility model can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should all be covered within the protection scope of the present utility model. Therefore, the protection scope of the present utility model should be subject to the protection scope of the claims.
Claims
1. A microfluidic analyzer, characterized in that: include: A microfluidic disc comprises a disc body, a diluent capsule and a cover plate, wherein the disc body comprises a first surface, the first surface is provided with a microgroove structure and a receiving groove, the diluent capsule is received in the receiving groove, the cover plate is connected to the disc body and covers the first surface, a puncture structure is provided on a side of the cover plate facing the diluent capsule and opposite to the diluent capsule, and an opening communicating with the receiving groove is provided on the bottom wall of the receiving groove; A rotation drive mechanism, comprising a turntable and a first drive member, wherein the turntable is used to carry the microfluidic disk, the turntable is provided with a through hole, when the microfluidic disk is placed on the turntable, the through hole is opposite to the opening, and the first drive member is used to drive the turntable to rotate; The lifting mechanism comprises a push rod assembly, a cam and a second driving member, wherein the push rod assembly comprises a push rod, a buckle and a push rod, wherein the buckle can be movably mounted on the push rod in a radial direction, and the push rod can be movably penetrated through the push rod, and the push rod is used to drive the buckle to extend out of the outside of the push rod or retract into the inside of the push rod, and the cam is provided with a first track and a second track, and the bottom end of the push rod abuts against the first track, and the bottom end of the push rod abuts against the second track, and the second driving member is used to drive the cam to rotate, so as to drive the push rod to pass through the through hole and the opening to push the diluent capsule toward the puncture structure, and drive the buckle to extend out of the outside of the push rod to be clamped on the bottom wall of the groove.
2. The microfluidic analyzer according to claim 1, characterized in that: The first track and the second track have different travel distances.
3. The microfluidic analyzer according to claim 1, characterized in that: The cam includes a first cam portion and a second cam portion stacked with the first cam portion, the outer peripheral surface of the first cam portion is the first track, and the outer peripheral surface of the second cam portion is the second track; At least one of the first cam portion and the second cam portion is eccentrically disposed.
4. The microfluidic analyzer according to claim 1, characterized in that: The outer side wall of the push rod is provided with a matching hole, the buckle can be movably embedded in the matching hole, the outer side wall of the push rod is provided with a matching groove, and the push rod has a first position and a second position under the drive of the second track; In the first position, the outer side wall of the push rod is opposite to the matching hole, and the buckle extends out of the outer side of the push rod due to the abutment of the outer side wall of the push rod; In the second position, the matching groove is opposite to the matching hole, and the buckle is retracted into the interior of the ejector rod and embedded in the matching groove.
5. The microfluidic analyzer according to claim 1, characterized in that: The microfluidic analyzer also includes a pulling member for generating pulling force. When the locking member extends out of the outer side of the push rod and is clamped on the bottom wall of the groove, the pulling force pulls the push rod toward the cam to press the bottom wall of the groove against the turntable.
6. The microfluidic analyzer according to claim 5, characterized in that: The tension member comprises a spring, an outer side wall of the push rod is provided with an abutment portion, the spring is sleeved on the push rod, one end of the spring abuts against the rotation drive mechanism, and the other end of the spring abuts against the abutment portion.
7. The microfluidic analyzer according to claim 1, characterized in that: The lifting mechanism further includes a supporting member, the cam is disposed between the second driving member and the supporting member, the cam is rotatably connected to the supporting member, and the supporting member is used to support the cam.
8. The microfluidic analyzer according to claim 1, characterized in that: The side of the turntable used for supporting the microfluidic disk includes a guide surface and a support surface, the support surface is used for supporting the microfluidic disk, the guide surface surrounds the support surface, and the guide surface is inclined to the rotation center line of the turntable.
9. The microfluidic analyzer according to claim 8, characterized in that: The bottom of the microfluidic disk is provided with a first positioning portion, and the supporting surface of the turntable is provided with a second positioning portion, and the second positioning portion is used to cooperate with the first positioning portion to position the microfluidic disk and install it on the turntable.
10. The microfluidic analyzer according to claim 1, characterized in that: The microfluidic analyzer further comprises a housing component and a door component, the rotation drive mechanism and the lifting mechanism are arranged inside the housing component, the housing component is provided with a window communicating with the interior of the housing component, the door component can be pulled out and arranged at the window, and the door component is provided with a placement position for placing the microfluidic disc; The bin door assembly has an open position and a closed position. In the open position, the placement position is exposed from the shell assembly, and in the closed position, the placement position is located above the turntable.
11. The microfluidic analyzer according to claim 10, characterized in that: The disc body includes a disc portion and a column portion provided at the bottom of the disc portion, the door assembly is provided with a disc placement opening to form the placement position, and when the microfluidic disc is placed at the placement position, the column portion is embedded in the disc placement opening; The diameter of the disk placement opening is greater than the diameter of the column portion.
12. The microfluidic analyzer according to claim 1, characterized in that: The disc body further comprises a plurality of protrusions, which are arranged around the opening at intervals on the bottom wall of the accommodating groove, and a recessed portion for engaging with the buckle is formed between two adjacent protrusions.
13. The microfluidic analyzer according to claim 12, characterized in that: The cross-sectional profile of the protrusion is a triangle.
14. The microfluidic analyzer according to claim 1, characterized in that: The microfluidic analyzer also includes a temperature control unit, which is connected to the rotary drive mechanism. The temperature control unit and the rotary drive mechanism enclose a processing chamber and an opening connected to the processing chamber. The turntable is located in the processing chamber, and the microfluidic disc enters the processing chamber through the opening.
15. A microfluidic analyzer, characterized in that: include: The rotary drive mechanism comprises a turntable and a first drive member, wherein the turntable is used to carry the microfluidic disk, the turntable is provided with a through hole, when the microfluidic disk is placed on the turntable, the through hole is opposite to the opening of the bottom wall of the accommodating tank of the microfluidic disk accommodating the dilution liquid capsule, and the first drive member is used to drive the turntable to rotate; The lifting mechanism comprises a push rod assembly, a cam and a second driving member, wherein the push rod assembly comprises a push rod, a buckle and a push rod, wherein the buckle can be movably mounted on the push rod in a radial direction, and the push rod can be movably penetrated through the push rod, and the push rod is used to drive the buckle to extend out of the outside of the push rod or retract into the inside of the push rod, and the cam is provided with a first track and a second track, the bottom end of the push rod abuts against the first track, and the bottom end of the push rod abuts against the second track, and the second driving member is used to drive the cam to rotate, so as to drive the push rod to pass through the through hole and the opening to push the dilution liquid capsule toward the puncture structure of the microfluidic disc, and drive the buckle to extend out of the outside of the push rod to be clamped on the bottom wall of the groove.