Column oven and ion chromatograph

Abstract

The utility model provides a column oven and an ion chromatograph, the column oven comprises a constant temperature mechanism, the constant temperature mechanism comprises a heat conduction block, a preheating pipe and a circuit board, the preheating pipe is arranged on the heat conduction block, the circuit board is connected with the heat conduction block and used for covering at least part of the structure of the preheating pipe, and the circuit board is used for providing energy required by heating temperature control for the heat conduction block; and the chromatographic column is connected to the preheating pipe. The preheating pipe and the circuit board are both connected to the heat conduction block, the circuit board provides energy required by heating and temperature control, and then the energy is conducted to the preheating pipe through the heat conduction block, so that the leacheate is preheated in advance, meanwhile, the chromatographic column can be in a constant environment temperature, the stability of the chromatographic column can be accurately and stably controlled, the sensitivity of the chromatographic column can be improved, and the detection accuracy is improved. The separation degree of spectrum peaks is improved, the separation rate is increased, the analysis time is shortened, and the accuracy and reproducibility of analysis results are ensured.

Description

Technical Field

[0001] The present application relates to the technical field of ion chromatographs, and more particularly, to an oven and an ion chromatograph. Background Art

[0002] Ion chromatography is a liquid chromatography method for analyzing anions and cations, and conductivity detection has become the most important detection method in ion chromatography due to its wide linear range, good selectivity, simple structure, and easy automatic operation.

[0003] In related technologies, as a temperature control instrument for an ion chromatograph, the temperature control of the oven is one of the key factors that need to be controlled during the development and conversion of chromatographic methods. Summary of the Utility Model

[0004] The purpose of the present application is to provide an oven and an ion chromatograph that can preheat the eluent in advance and keep the chromatographic column in a constant temperature environment.

[0005] In a first aspect, an embodiment of the present application provides an oven, including: a constant temperature mechanism, including a heat conducting block, a preheating tube, and a circuit board, the preheating tube is disposed on the heat conducting block, and the circuit board is connected to the heat conducting block to cover at least a part of the structure of the preheating tube, wherein the circuit board is used to provide the energy required for heating and temperature control to the heat conducting block; a chromatographic column, which is connected to the preheating tube.

[0006] In the above implementation process, both the preheating tube and the circuit board are connected to the heat conducting block. After the circuit board provides the energy required for heating and temperature control, it is conducted to the preheating tube by the heat conducting block, realizing the preheating of the eluent in advance. At the same time, the chromatographic column can also be in a constant ambient temperature, which can accurately and stably control the stability of the chromatographic column, is beneficial to improving the sensitivity of the chromatographic column, improving the resolution of chromatographic peaks, accelerating the separation rate, shortening the analysis time, and ensuring the accuracy and reproducibility of the analysis results.

[0007] In some embodiments, the heat conducting block is provided with a preheating groove in a first direction, the preheating groove is located on a side of the heat conducting block close to the circuit board, and the preheating groove is configured to accommodate the preheating tube.

[0008] In the above implementation process, the preheating groove of the heat conducting block can be used to accommodate the preheating tube, realizing the limitation of the preheating tube. And through this preheating tube, the eluent can be preheated in advance, so that the chromatographic column is in a constant temperature environment, and at the same time, it plays a buffering role, reduces pressure fluctuations, and reduces the impact on the chromatographic column.

[0009] In some embodiments, the circuit board includes a heating resistor, a temperature-controlled switch, a thermistor and a PCB board, the heating resistor, the temperature-controlled switch and the thermistor are connected to the PCB board, the heating resistor is configured in the inner cavity of the thermally conductive block, and the temperature-controlled switch and the thermistor are located on a side of the PCB board close to the thermally conductive block.

[0010] In the above implementation process, the heating resistor is used to evenly provide the energy required for heating and temperature control, and the thermistor is used as a temperature probe to conveniently measure the temperature inside the heat conductive block. The temperature control switch and the thermistor work together to control the start and stop of the heating resistor to prevent exceeding the high temperature upper limit.

[0011] In some embodiments, the column oven further comprises a filler, and the filler is filled in a gap formed between the preheating tube and the circuit board and the heat conductive block after the circuit board is connected to the heat conductive block.

[0012] In the above implementation process, the filler is filled in the gap formed by the heat conductive block, which can conduct heat and preheat the eluent in advance so that the chromatographic column is in a constant temperature environment, and at the same time fix the preheating tube.

[0013] In some embodiments, the column oven further comprises a heat conducting member, and the heat conducting member is provided in plurality, and the temperature control switch and the heating resistor are both attached with the heat conducting member, and the heat conducting member is located in the inner cavity of the heat conducting block, so as to fill the fitting gap formed between the temperature control switch and the heat conducting block and between the heating resistor and the heat conducting block, thereby increasing the heat conducting efficiency.

[0014] In some embodiments, a mounting groove is disposed on a side of the heat conducting block away from the circuit board, and the mounting groove is configured to accommodate the chromatographic column. The mounting groove can not only fix the chromatographic column, but also can be used to adapt to chromatographic columns of different specifications and thicknesses, which is conducive to improving the compactness of the overall structure, thereby improving space utilization.

[0015] In some embodiments, the column oven further comprises a housing mechanism, wherein the housing mechanism is provided with a receiving cavity, and the receiving cavity is configured to receive the constant temperature mechanism and the chromatographic column.

[0016] In the above-mentioned implementation process, after the shell mechanism accommodates the constant temperature mechanism and the chromatographic column, the constant temperature mechanism provides the energy required for heating and temperature control, preheats the eluent in advance, and the shell mechanism can be heat-insulated, so that the chromatographic column is in a constant temperature environment, and the stability of the chromatographic column can be accurately and stably controlled, which is beneficial to improving the sensitivity of the chromatographic column, improving the separation of spectral peaks, accelerating the separation rate, shortening the analysis time, and ensuring the accuracy and reproducibility of the analysis results.

[0017] In some embodiments, the housing mechanism includes a bottom case, a front cover, and a heat insulation member. The front cover is connected to the bottom case, and the heat insulation member is disposed on the bottom case.

[0018] In the above implementation process, the heat insulation member is located inside the bottom case. The heat insulation mechanism and the chromatographic column are installed in the accommodation cavity formed by the bottom case and the front cover. The heat insulation member can play a role in preventing heat dissipation, enabling the chromatographic column to be in a constant temperature environment, accurately and stably controlling the stability of the chromatographic column, facilitating improving the sensitivity of the chromatographic column, improving the resolution of spectral peaks, accelerating the separation rate, shortening the analysis time, and ensuring the accuracy and reproducibility of the analysis results.

[0019] In some embodiments, the bottom case is provided with a partition wall along a first direction to divide the bottom case into two chambers, and each chamber is provided with the constant temperature mechanism and the chromatographic column.

[0020] In the above implementation process, the constant temperature mechanism and the chromatographic column are arranged in the chamber, and the adjacent two chambers are separated by the partition wall, which can prevent the heat of the two chambers from colluding, and each part is temperature-controlled separately without mutual influence.

[0021] In a second aspect, the present application also provides an ion chromatograph, including the column oven as described in any one of the above.

[0022] Since the ion chromatograph provided in the second aspect includes the column oven, the ion chromatograph has all the technical effects of the column oven, which will not be elaborated herein.

[0023] Other features and advantages of the present application will be described in the subsequent specification, or some features and advantages can be inferred from the specification or determined without doubt, or can be known by implementing the above technologies of the present application.

[0024] To make the above objects, features, and advantages of the present application more obvious and understandable, the following specific preferred embodiments are given in conjunction with the accompanying drawings and are described in detail as follows. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] To more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings required to be used in the embodiments of the present application. It should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can be obtained based on these drawings without creative efforts.

[0026] Figure 1 It is a schematic structural diagram of the column oven provided by the embodiment of the present application;

[0027] Figure 2 It is an exploded view of the column oven provided by the embodiment of the present application;

[0028] Figure 3 Schematic structural diagram of the heat conduction block of the column oven provided by the embodiment of the present application;

[0029] Figure 4 Schematic structural diagram of the circuit board of the column oven provided by the embodiment of the present application;

[0030] Figure 5 Schematic structural diagram of the bottom shell of the column oven provided by the embodiment of the present application;

[0031] Figure 6 Schematic structural diagram of the chromatographic column with a memory function provided by the embodiment of the present application;

[0032] Figure 7 Explosion schematic diagram of the chromatographic column with a memory function provided by the embodiment of the present application;

[0033] Figure 8 Cross-sectional view of the chromatographic column with a memory function provided by the embodiment of the present application;

[0034] Figure 9 Schematic structural diagram of the chromatographic column with an identification function provided by the embodiment of the present application;

[0035] Figure 10 Explosion schematic diagram of the chromatographic column with an identification function provided by the embodiment of the present application;

[0036] Figure 11 Cross-sectional view of the chromatographic column with an identification function provided by the embodiment of the present application;

[0037] Figure 12 Schematic principle diagram of the chromatographic column with an identification function provided by the embodiment of the present application.

[0038] Reference numerals: 100, constant temperature mechanism; 101, heat conduction block; 1011, preheating tank; 1012, temperature control hole; 1013, heating tank; 1014, installation groove; 102, preheating tube; 103, circuit board; 1031, heating resistor; 1032, temperature control switch; 1033, thermistor; 1034, PCB board; 1035, terminal; 200, chromatographic column; 300, heat conducting member; 400, housing mechanism; 401, bottom shell; 4011, pipe outlet groove; 4012, partition wall; 4013, chamber; 402, front cover; 403, heat insulation member; 404, transparent window; 500, pressing plate; 600, screw; 700, memory mechanism; 701, fixed seat; 702, pressing plate; 703, memory chip; 704, waterproof joint; 705, first colloid; 800, identification mechanism; 801, connecting seat; 802, connecting plate; 803, identification resistor; 804, identification joint; 805, second colloid. Detailed implementation manners

[0039] The following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. The components of the embodiments of the present application usually described and shown in the accompanying drawings here can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the accompanying drawings is not intended to limit the scope of the present application to be protected, but only represents the selected embodiments of the present application. All other embodiments obtained by those skilled in the art based on the embodiments of the present application without creative efforts belong to the scope of protection of the present application.

[0040] In the present application, the orientation or positional relationship indicated by terms such as "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", etc. is based on the orientation or positional relationship shown in the accompanying drawings. These terms are mainly used to better describe the present application and its embodiments, and are not used to limit that the indicated devices, elements or components must have a specific orientation, or be constructed and operated in a specific orientation.

[0041] Moreover, in addition to being able to represent the orientation or positional relationship, some of the above terms may also be used to represent other meanings. For example, the term "upper" may also be used to represent a certain attachment relationship or connection relationship in some cases. For those of ordinary skill in the art, the specific meanings of these terms in the present application can be understood according to specific circumstances.

[0042] In addition, the terms "mounted", "arranged", "provided with", "connected", "linked" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection, or a point connection; it can be directly connected, or indirectly connected through an intermediate medium, or there is internal communication between two devices, elements or components. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0043] In addition, the terms "first", "second", etc. are mainly used to distinguish different devices, elements or components (the specific types and structures may be the same or different), and are not used to indicate or imply the relative importance and quantity of the indicated devices, elements or components. Unless otherwise stated, the meaning of "a plurality" is two or more. Embodiment

[0044] Ion chromatography is a type of high-performance liquid chromatography, so it is also known as high-performance ion chromatography or modern ion chromatography. The main difference from traditional ion exchange chromatography columns is that the resin has a very high cross-linking degree and a low exchange capacity. The injection volume is very small, and when using a piston pump to deliver the eluent, on-line automatic continuous conductivity detection of the eluent is usually carried out. Separating and determining common anions is the specialty of ion chromatographs. When a sample is injected, the determination results of 7 common ions can be obtained within about 20 minutes, which cannot be achieved by other analytical methods. For the determination of cations, ion chromatography does not show superiority compared with AAS and ICP methods.

[0045] Ion chromatography is mainly used for the analysis of environmental samples, including anions and cations in surface water, drinking water, rainwater, domestic sewage and industrial wastewater, acid deposition and atmospheric particulate matter, etc., and the analysis of trace impurities in water and reagents related to the microelectronics industry.

[0046] The column oven is a temperature control instrument used in the analysis of liquid chromatographs to keep the temperature of the chromatographic column constant. It can accurately and stably control the stability of the chromatographic analysis column, which is beneficial to improving the sensitivity of the chromatographic column, improving the separation degree of chromatographic peaks, accelerating the separation rate, shortening the analysis time, and ensuring the accuracy and reproducibility of the analysis results.

[0047] The separation temperature will affect the retention time, selectivity and peak shape. Temperature is one of the key factors that need to be controlled during the development and conversion of chromatographic methods. In the prior art, the flow path pressure is prone to fluctuations, which affects the life of the chromatographic column, and the temperature is unstable, which affects the measurement accuracy.

[0048] As Figures 1-5 shown, in a first aspect, an embodiment of the present application provides a column oven, including: a constant temperature mechanism 100, including a heat conduction block 101, a preheating tube 102 and a circuit board 103. The preheating tube 102 is arranged on the heat conduction block 101, and the circuit board 103 is connected to the heat conduction block 101 to cover at least part of the structure of the preheating tube 102, wherein the circuit board 103 is used to provide the energy required for heating and temperature control to the heat conduction block 101; a chromatographic column 200, which is connected to the preheating tube 102.

[0049] Exemplarily, the chromatographic column 200 uses an ion exchanger with ion exchange groups on the surface as the stationary phase. Negatively charged exchange groups (such as sulfonic acid groups and carboxylic acid groups) can be used for the separation of cations; positively charged exchange groups (such as quaternary ammonium salts) can be used for the separation of anions; different ions have different interaction forces with the exchange groups and different retention times in the resin, so they are separated from each other.

[0050] One end of the preheating tube 102 is connected to the chromatographic column 200 through a PEEK joint, and the other end is connected to other external accessories. For example, the other end of the preheating tube 102 is connected to an in-line filter of an ion chromatograph.

[0051] As Figures 6-8 shown, a memory mechanism 700 can be provided on the chromatographic column 200. The memory 700 has a memory function and can assist customers in accurately calculating the service life of the chromatographic column 200. The memory mechanism 700 includes a fixing component, a memory chip 703, and a waterproof connector 704. The fixing component includes a fixing base 701 and a pressing plate 702. The fixing base 701 is connected to the pressing plate 702 by screws and fixed on the chromatographic column 200. It can adjust the starting time and be compatible with different models of chromatographic columns 200 in a detachable manner. The memory chip 703 is welded to the waterproof connector 704, and the memory chip 703 is inserted into the fixing component, and then sealed with a specific first colloid 705 to prevent the eluent from contacting and corroding the memory chip 703. One end of the waterproof connector 704 facing away from the memory chip 703 is used to connect to the circuit board of the ion chromatograph, so that after each startup and operation, the computer automatically accumulates the usage time, and at the same time, the computer displays that the chromatographic column 200 is online, preventing the situation of no chromatographic column and invalid operation of the ion chromatograph. It should be noted that the position where the memory chip is installed on the chromatographic column through the fixing component is not specifically limited and can be adjusted according to actual situations.

[0052] As Figures 9-12 shown, an identification mechanism 800 can also be provided on the chromatographic column 200. Through the identification mechanism 800, the model of the chromatographic column 200 and whether the chromatographic column 200 is online can be automatically identified. Specifically, the identification mechanism 800 includes a connection component, an identification resistor 803, and an identification connector 804. The connection component includes a connection base 801 and a connection plate 802. The connection base 801 is connected to the connection plate 802 by screws and fixed on the chromatographic column 200. The identification resistor 803 is welded to the identification connector 804, and the identification resistor 803 is inserted into the connection component, and then sealed with a specific second colloid 805 to prevent the eluent from contacting and corroding the identification resistor 803. One end of the identification connector 804 facing away from the identification resistor 803 is used to connect to the circuit board of the ion chromatograph. The ion chromatograph and the computer read the voltage value of the voltage division of the identification resistor 803, and the ion chromatograph and the computer display the specification model of the chromatographic column 200 and whether the chromatographic column is online, preventing the situation of incorrect use of the chromatographic column 200 and invalid operation of the ion chromatograph without a chromatographic column.

[0053] The ion chromatograph and the computer terminal preset different voltage values for different models of chromatographic columns. For example, when the voltage value is 0.455V, it shows a chromatographic column of specification model A.

[0054] For example, voltage VCC = 5V, resistance Ra (i.e., identification resistance 803) = 10KΩ, resistance Rb = 1KΩ, voltage detection V = VCC * Rb / (Ra + Rb) = 0.455V

[0055] At this time, the ion chromatograph and the computer terminal display a chromatographic column of specification model A.

[0056] The ion chromatograph and the computer terminal preset different voltage values for different models of chromatographic columns. For example, when the voltage value is 1.667V, it shows a chromatographic column of specification model B.

[0057] For example, voltage VCC = 5V, resistance Ra = 10KΩ, resistance Rb = 5KΩ, voltage detection V = VCC * Rb / (Ra + Rb) = 1.667V

[0058] At this time, the ion chromatograph and the computer terminal display a chromatographic column of specification model B.

[0059] The ion chromatograph and the computer terminal preset different voltage values for different models of chromatographic columns. For example, when the voltage value is 5V, it shows that no chromatographic column is installed.

[0060] For example, if no chromatographic column is installed, then resistance Rb is infinite, and voltage detection V = VCC * Rb / (Ra + Rb) = 5V

[0061] At this time, the ion chromatograph and the computer terminal display that no chromatographic column is installed; by adding resistors with different resistance values to generate different voltages, different voltages are preset at the ion chromatograph and the computer terminal to represent different models, and the factory preset models are automatically identified.

[0062] In the above implementation process, the preheating tube 102 and the circuit board 103 are both connected to the heat conducting block 101. After the circuit board 103 provides the energy required for heating and temperature control, it is conducted to the preheating tube 102 by the heat conducting block 101 to realize the preheating of the eluent in advance. At the same time, the chromatographic column 200 can also be in a constant ambient temperature, which can accurately and stably control the stability of the chromatographic column 200, is beneficial to improving the sensitivity of the chromatographic column 200, improving the resolution of the chromatographic peaks, accelerating the separation rate, shortening the analysis time, and ensuring the accuracy and reproducibility of the analysis results.

[0063] Such as Figures 1-3As shown, the heat conduction block 101 is provided with a preheating groove 1011 along a first direction, which includes but is not limited to the up-down direction. The preheating groove 1011 is located on the side of the heat conduction block 101 close to the circuit board 103. The preheating groove 1011 is configured to be open, and the opening direction of the preheating groove 1011 faces the circuit board 103, and the preheating groove 1011 is configured to accommodate the preheating tube 102.

[0064] In the above implementation process, the preheating groove 1011 of the heat conduction block 101 can be used to accommodate the preheating tube 102 to realize the limitation of the preheating tube 102. And through the preheating tube 102, the eluent can be preheated in advance, so that the chromatographic column 200 is in a constant temperature environment, and at the same time, it plays a buffering role, reduces the pressure fluctuation, and reduces the impact on the chromatographic column 200.

[0065] As Figure 4 shown, the circuit board 103 includes a heating resistor 1031, a temperature control switch 1032, a thermistor 1033 and a PCB board 1034. The heating resistor 1031, the temperature control switch 1032 and the thermistor 1033 are connected to the PCB board 1034. The heating resistor 1031 is disposed in the inner cavity of the heat conduction block 101. For example, the heat conduction block 101 is provided with a heating groove 1013, and the heating groove 1013 is configured to accommodate the heating resistor 1031. The temperature control switch 1032 and the thermistor 1033 are located on the side of the PCB board 1034 close to the heat conduction block 101.

[0066] Exemplarily, the heating resistor 1031 is a heat source. The heating resistor 1031 includes but is not limited to four. The four heating resistors 1031 are spaced apart on the PCB board 1034, and the four heating resistors 1031 jointly provide energy to form a multi-point heat source, which can provide energy more evenly.

[0067] It can be understood that compared with a customized silicone heating sheet, the heating resistor 1031 does not need to be customized, is convenient to purchase and install, can be adjusted flexibly, and has strong high-temperature and aging resistance.

[0068] The heat conducting block 101 is configured with a temperature control hole 1012, and the thermistor 1033 is inserted into the temperature control hole 1012. The thermistor 1033 includes but is not limited to an NTC resistor. The number of the thermistors 1033 includes but is not limited to three. The three thermistors 1033 are respectively located at the upper, middle and lower parts of the heat conducting block 101. The thermistor 1033 located in the middle penetrates the heat conducting block 101 but does not protrude from the heat conducting block 101, while the thermistors 1033 located at the upper and lower parts do not penetrate the heat conducting block 101, which is convenient for measuring the temperature inside the heat conducting block 101, forming multi-point measurement to achieve accurate temperature measurement.

[0069] Certainly, the circuit board 103 further includes a terminal 1035. The terminal 1035 is arranged on the PCB board 1034. After the column oven is installed on the ion chromatograph, one end of a wire is conveniently inserted into the terminal 1035, and the other end of the wire is connected to the circuit board of the ion chromatograph. Different temperatures are set through the computer terminal to realize system temperature control.

[0070] In the above implementation process, the heating resistor 1031 is used to uniformly provide the energy required for heating temperature control, and the thermistor 1033 is used as a temperature probe to conveniently measure the temperature inside the heat conducting block 101. The temperature control switch 1032 and the thermistor 1033 act together to control the start and stop of the heating resistor 1031 to prevent exceeding the high temperature limit.

[0071] In some embodiments, the column oven further includes a filler. The filler is a high heat conducting material. The filler is filled in the gap formed between the preheating tube 102 and the heat conducting block 101 after the circuit board 103 is connected to the heat conducting block 101. Before use, the filler is in a highly fluid liquid state, and after potting and drying, it becomes a high-strength solid state to fix the preheating tube 102.

[0072] In the above implementation process, the filler is filled in the gap formed by the heat conducting block 101. It can not only conduct heat to preheat the eluent in advance, so that the chromatographic column 200 is in a constant temperature environment, but also fix the preheating tube 102.

[0073] Such as Figure 2As shown, the column oven further includes a heat conductive member 300, which includes but is not limited to a heat conductive silicone sheet, and the heat conductive member 300 is configured in plurality, and the temperature control switch 1032 and the heating resistor 1031 are both attached with the heat conductive member 300 and fastened with screws 600, and the heat conductive member 300 is located in the inner cavity of the heat conductive block 101, for example, the heat conductive member 300 is located in the heating groove 1013 of the heat conductive block 101. The fitting gaps formed by the temperature control switch 1032 and the heat conductive block 101 and the heating resistor 1031 and the heat conductive block 101 can be filled, thereby increasing the heat conduction efficiency.

[0074] like Figures 1-2 As shown, a mounting groove 1014 is disposed on a side of the heat conductive block 101 away from the circuit board 103, and the mounting groove 1014 is configured to accommodate the chromatographic column 200. Exemplarily, the column oven further comprises a pressing plate 500, and the pressing plate 500 is disposed on a side of the heat conductive block 101 close to the chromatographic column 200, so that when the chromatographic column 200 is installed in the mounting groove 1014, the pressing plate 500 is fixed to the heat conductive block 101, thereby fixing the chromatographic column 200, wherein the mounting groove 1014 includes but is not limited to a semicircular notch, and chromatographic columns 200 of different specifications can be used.

[0075] The mounting groove 1014 can not only fix the chromatographic column 200 , but also can be used to adapt to chromatographic columns 200 of different specifications and thicknesses, which is beneficial to improving the compactness of the overall structure and thus improving space utilization.

[0076] In some embodiments, the column oven further includes a housing mechanism 400 , wherein the housing mechanism 400 is provided with a receiving cavity, and the receiving cavity is configured to receive the constant temperature mechanism 100 and the chromatographic column 200 .

[0077] In the above-mentioned implementation process, after the shell mechanism 400 accommodates the constant temperature mechanism 100 and the chromatographic column 200, the constant temperature mechanism 100 provides the energy required for heating and temperature control, and preheats the eluent in advance. At the same time, the shell mechanism 400 can be insulated, so that the chromatographic column 200 is in a constant temperature environment, and the stability of the chromatographic column 200 can be accurately and stably controlled, which is beneficial to improving the sensitivity of the chromatographic column 200, improving the separation of spectral peaks, accelerating the separation rate, shortening the analysis time, and ensuring the accuracy and reproducibility of the analysis results.

[0078] like Figures 1-2As shown, the housing mechanism 400 includes a bottom case 401, a front cover 402, and a heat-insulating member 403. The front cover 402 is connected to the bottom case 401, and the heat-insulating member 403 is disposed on the bottom case 401. The heat-insulating member 403 includes but is not limited to heat-insulating cotton, and the heat-insulating cotton has an adhesive backing and can be directly pasted on the bottom case 401.

[0079] Exemplarily, the bottom case 401 is an integrally formed part made of a material with a low thermal conductivity coefficient, which can reduce heat dissipation. A pipe outlet groove 4011 can be configured at the bottom of the bottom case 401. The pipe outlet groove 4011 can be used as both the inlet and outlet of the eluent pipeline and as a liquid leakage hole. The front cover 402 is provided with a notch, and the notch position is bonded through a transparent window 404 to form a whole, and it is possible to observe whether the joint of the chromatographic column 200 leaks water through the transparent window 404 at any time.

[0080] In the above implementation process, the heat-insulating member 403 is located inside the bottom case 401. The heat-insulating mechanism and the chromatographic column 200 are installed in the accommodation cavity formed by the bottom case 401 and the front cover 402. The heat-insulating member 403 can play a role in preventing heat dissipation, so that the chromatographic column 200 is in a constant temperature environment, and the stability of the chromatographic column 200 can be accurately and stably controlled, which is beneficial to improving the sensitivity of the chromatographic column 200, improving the resolution of chromatographic peaks, accelerating the separation rate, shortening the analysis time, and ensuring the accuracy and reproducibility of the analysis results.

[0081] In some embodiments, the bottom case 401 is provided with a partition wall 4012 along a first direction to divide the bottom case 401 into two chambers 4013, and each chamber 4013 is provided with the constant temperature mechanism 100 and the chromatographic column 200. It can be understood that by providing the partition wall 4012 inside the bottom case 401, the interior of the bottom case 401 is divided into two chambers 4013 distributed left and right. The two chambers 4013 can be used for a dual-channel ion chromatograph or a single-channel one, and a spare column can be placed in one of the chambers 4013.

[0082] In the above implementation process, the constant temperature mechanism 100 and the chromatographic column 200 are provided in the chamber 4013, and the adjacent two chambers 4013 are separated by the partition wall 4012, which can prevent the heat of the two chambers 4013 from colluding, and each part is temperature-controlled separately without mutual influence.

[0083] In a second aspect, the present application further provides an ion chromatograph, including the column oven as described above.

[0084] The working process of the ion chromatograph is as follows: The infusion pump transports the mobile phase to the analysis system at a stable flow rate (or pressure). Before the chromatographic column, the sample is introduced through an injector. The mobile phase carries the sample into the chromatographic column, where each component is separated and then flows to the conductivity detector successively with the mobile phase. For suppressed ion chromatography, an additional suppression system is added before the conductivity detector. That is, another high-pressure infusion pump transports the regeneration liquid to the suppressor. In the suppressor, the background conductivity of the mobile phase is reduced, and then the effluent is introduced into the conductivity detector. The detected signal is sent to the data system for recording, processing, or storage.

[0085] Since the ion chromatograph provided in the second aspect includes an oven, the ion chromatograph has all the technical effects of the oven, which will not be elaborated here.

[0086] In all embodiments of the present application, "large" and "small" are relative, "many" and "few" are relative, and "upper" and "lower" are relative. For the expression of such relative terms, the embodiments of the present application will not elaborate further.

[0087] It should be understood that the phrases "in this embodiment", "in the embodiments of the present application", or "as an optional implementation manner" mentioned throughout the specification mean that the specific features, structures, or characteristics related to the embodiment are included in at least one embodiment of the present application. Therefore, the phrases "in this embodiment", "in the embodiments of the present application", or "as an optional implementation manner" that appear throughout the specification do not necessarily refer to the same embodiment. In addition, these specific features, structures, or characteristics can be combined in one or more embodiments in any suitable manner. Those skilled in the art should also be aware that the embodiments described in the specification are all optional embodiments, and the actions and modules involved are not necessarily essential to the present application.

[0088] In various embodiments of the present application, it should be understood that the magnitudes of the serial numbers of the above processes do not necessarily mean the inevitable sequence of execution. The execution sequence of each process should be determined by its function and internal logic, and should not constitute any limitation to the implementation process of the embodiments of the present application.

[0089] The above is only the specific implementation manner of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present application, and all should be covered by the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A column oven, characterized in that, include: The constant temperature mechanism comprises a heat conducting block, a preheating tube and a circuit board, wherein the preheating tube is arranged on the heat conducting block, and the circuit board is connected to the heat conducting block to cover at least a part of the structure of the preheating tube, wherein the circuit board is used to provide the heat conducting block with energy required for heating and temperature control; A chromatographic column is connected to the preheated tube.

2. The column oven according to claim 1, wherein The heat conducting block is provided with a preheating groove along a first direction. The preheating groove is located on a side of the heat conducting block close to the circuit board, and the preheating groove is configured to accommodate the preheating tube.

3. The column oven according to claim 2, characterized in that, The circuit board includes a heating resistor, a temperature-controlled switch, a thermistor and a PCB board. The heating resistor, the temperature-controlled switch and the thermistor are connected to the PCB board. The heating resistor is configured in the inner cavity of the heat-conducting block. The temperature-controlled switch and the thermistor are located on a side of the PCB board close to the heat-conducting block.

4. The column oven according to claim 3, characterized in that, The column oven further comprises a filler, and the filler is filled in a gap formed between the preheating tube and the circuit board and the heat-conducting block after the circuit board is connected to the heat-conducting block.

5. The column oven according to claim 3, characterized in that, The column temperature box also includes a heat conductive member, and a plurality of heat conductive members are configured. The temperature control switch and the heating resistor are both attached with the heat conductive member, and the heat conductive member is located in the inner cavity of the heat conductive block.

6. The column oven according to claim 1, wherein A mounting groove is arranged on a side of the heat conducting block facing away from the circuit board, and the mounting groove is configured to accommodate the chromatographic column.

7. The column oven according to any one of claims 1 to 6, characterized in that, The column oven further comprises a housing mechanism, wherein the housing mechanism is provided with a containing cavity, and the containing cavity is configured to contain the constant temperature mechanism and the chromatographic column.

8. The column oven according to claim 7, characterized in that, The housing structure comprises a bottom shell, a front cover and a heat-insulating component. The front cover is connected to the bottom shell, and the heat-insulating component is arranged on the bottom shell.

9. The column oven according to claim 8, wherein, The bottom shell is provided with a partition wall along a first direction to separate the bottom shell into two chambers, and each of the chambers is provided with the constant temperature mechanism and the chromatographic column.

10. An ion chromatograph, characterized in that, Comprising a column oven as described in any one of claims 1 to 9.

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