Deoxidizing device and granulator for preparing powdery material molten solid dispersion

Abstract

The utility model relates to the technical field of granulation equipment for powdery material molten solid dispersions, in particular to a deoxygenization device for preparing powdery material molten solid dispersions and a granulator, the deoxygenization device comprises a material extrusion driving mechanism, a blanking pipe and a melting cavity, the melting cavity is communicated with a material port and an exhaust port, and the material port is communicated with the exhaust port. The discharging pipe is installed on the material port, a pipeline is installed on the discharging pipe, a pressure regulating valve set is arranged on the pipeline, and a filter is arranged on the exhaust port. According to the device, corresponding gas such as inert gas is controlled to be injected while materials are fed from the discharging pipe, the materials are pushed to the exhaust port through the material extrusion driving mechanism, mixed gas is discharged out of the materials, deoxygenization work in the pelletizing process can be efficiently achieved, the influence of oxygen on high-sensitivity materials is eliminated, and the quality of pelletized products is guaranteed.

Description

Technical Field

[0001] The utility model relates to a granulation device for a molten solid dispersion system of powdery materials, in particular to an oxygen removal device and a granulator for preparing a molten solid dispersion system of powdery materials. Background Art

[0002] Granulation is a process of agglomerating finer particles into coarser powder agglomerates to improve the fluidity of powders. Granulation is an operation of processing materials in the states of powders, molten liquids, aqueous solutions, etc. into granular materials with certain shapes and sizes. Almost all the preparation processes of solid preparations are inseparable from the granulation process. The granules produced may be the final products, such as granule agents; or they may be intermediate products, such as tablets.

[0003] In the existing granulation methods, high-temperature heat and pressure are used to melt and granulate powdery materials and lower-melting-point polymers, which belongs to a kind of solid dispersion preparation technology and can significantly improve solubility, and the process is simple and environmentally friendly. The usual high-temperature melting granulation production process utilizes the melting properties of materials under high temperature and high pressure, melts and extrudes the materials into shapes, and after passing through different die shapes, a cutting device cuts them into granular shapes. Extrusion molding mainly refers to a method in which the heated and melted materials are formed by the extrusion action of a screw or a plunger and are pushed through a die head by pressure. In the existing granulation equipment, for the oxygen contained in oxygen-sensitive materials, the method is to first extract the impurity gases in the sealed equipment and then fill a protective atmosphere. This method is relatively cumbersome in operation, affects the operation efficiency, and a large amount of oxygen will be introduced during the production process. Therefore, in the prior art, when manufacturing some drugs, raw materials, etc. that are highly sensitive to oxygen, the oxygen mixed in the powdery materials cannot be efficiently removed during the production process, which may cause the materials to oxidize, generate unacceptable impurities, resulting in a decrease in the purity of the materials, a decline in chemical properties, and seriously affect the product quality. Summary of the Utility Model

[0004] The purpose of the utility model is to overcome the problems in the prior art that the operation of removing oxygen in powdery materials during the preparation of a molten solid dispersion system of powdery materials is cumbersome and the effect is poor, resulting in oxidation of the materials and affecting the product quality. The utility model provides an oxygen removal device and a granulator for preparing a molten solid dispersion system of powdery materials.

[0005] The utility model provides an oxygen removal device for preparing a molten solid dispersion system of powdery materials, which comprises: a material extrusion driving mechanism, a feeding pipe and a melting cavity. The melting cavity is communicated with a material port and an exhaust port. The feeding pipe is installed on the material port. A pipeline is installed on the feeding pipe, and a pressure regulating valve group is arranged on the pipeline. A filter is arranged on the exhaust port.

[0006] The present utility model provides a deoxidation device for preparing a molten solid dispersion of powdery materials. Inert gas, nitrogen, or carbon dioxide is introduced into the space to be replaced through a pipeline, that is, into the feeding pipe of the present utility model. Based on the principle of gas diffusion, gas diffusion mainly depends on the pressure difference of the gas. By filling enough gas into the feeding pipe, the original oxygen in the powdery materials can be gradually displaced. This process is accompanied by a pressure change. The material extrusion driving mechanism pushes the powdery materials and the mixed gas to the exhaust port. Due to the pressure change, the gas and the oxygen in the materials are naturally released as a mixed gas after the materials are melted and discharged. Through the detection of the produced materials, there is a very small amount of mixed gas residue, but it has no impact on the product quality. Continuously introducing gas into the pipeline during the feeding process of the powdery materials can reduce the oxygen content. From the oxygen replacement tests and operation conditions of inert gas or nitrogen after the on-site hardware transformation, the system operates safely and stably. This solution can conveniently and quickly remove the oxygen in the powdery materials, meet the special production requirements for preparing the molten solid dispersion of the product, improve the production efficiency, and prevent highly sensitive materials from being oxidized.

[0007] Preferably, the pipeline, the feeding pipe, and the filter can be fixedly connected or detachably connected, such as connected in a quick chuck manner, etc., to facilitate disassembly, assembly, and cleaning.

[0008] Preferably, the material inlet and the feeding pipe can be detachably connected, and the exhaust port and the filter can be detachably connected, and bolt connection, standard chuck connection, etc. can be adopted.

[0009] Preferably, the feeding pipe is vertically installed, and the pipeline is obliquely connected to the wall of the feeding pipe. The oblique connection can slow down the flow rate change when the gas is injected into the feeding pipe. The oblique connection can effectively guide the gas so that the gas guiding direction is consistent with the material feeding direction, prevent the gas from affecting the normal feeding upward, and reduce the energy loss caused by suddenly changing the direction, improve the gas injection efficiency. The oblique connection can also reduce the impact of the gas on the inner wall of the pipeline, reduce wear and erosion.

[0010] Preferably, the pressure regulating valve group is installed on the pipeline. Through the pressure regulating valve group, the gas inlet flow rate and pressure can be controlled, and the pressure can be adjusted to keep the system within a safe range under the detected and indicated pressure values.

[0011] Preferably, the pipeline bends at the pressure regulating valve group, making the air inlet at the upper part of the pipeline vertically upward, which is convenient for maintenance and cleaning, optimizes the gas flow direction, and can improve safety when there is a risk of leakage.

[0012] Preferably, a cleaning port is provided at the top of the feeding pipe for convenient cleaning of the feeding pipe to ensure smoothness, prevent material blockage of the pipeline and excessive pressure, and extend the service life of the equipment.

[0013] Preferably, a material inlet is provided on the top side wall of the blanking pipe for conveying powdered materials into the blanking pipe, providing more sufficient space for blanking.

[0014] Preferably, the pipe is a seamless stainless steel pipe fitting, which has strong corrosion resistance and is not damaged during long-term use in material and drug production, extending the service life of the pipe. Moreover, seamless pipe fittings are stable and reliable under high pressure, reducing the risks of leakage and explosion.

[0015] Preferably, the extrusion driving mechanism includes an extrusion screw and a motor. Driven by the motor, the extrusion screw rotates to generate thrust and shear force to push the material forward and granulate.

[0016] Preferably, the extrusion element of the extrusion driving mechanism, i.e., the extrusion screw, can be a spiral die, a plunger, etc. The spiral die helps to uniformly mix the material, improving the consistency of product quality. The rotational propulsion effect can promote the melting of the material, enhancing production efficiency.

[0017] Preferably, a melting cavity is formed between the upper material heating body and the lower material heating body. Electric heating tubes are installed on both the upper material heating body and the lower material heating body to provide heat to heat the material above its melting point, melting the solid material to achieve the purpose of melt granulation.

[0018] Preferably, the upper material heating body can be lifted upward to open, facilitating the disassembly and installation of the extrusion screw in the cavity and cleaning the cavity.

[0019] Preferably, the distance between the exhaust port and the blanking pipe is set according to requirements during the design and manufacture of the equipment, so as to discharge the mixed gas at the initial stage of the melt granulation process, reducing the possibility of material oxidation in a high-temperature environment.

[0020] Preferably, a standard food-grade filter element is installed inside the filter for filtering the mixed gas and discharging it to the operation room. The filter can filter the waste gas, not only avoiding environmental pollution but also ensuring the health and safety of the workshop and personnel.

[0021] A granulator includes the granulator body and the deoxidation device for preparing a molten solid dispersion of a powdered material. By using this granulator, corresponding gases such as inert gases can be controlled to be injected while the material is fed from the blanking pipe, and the mixed gas can be discharged from the material by being pushed by the extrusion driving mechanism to the exhaust port, efficiently achieving the deoxidation work during the granulation process, eliminating the influence on highly sensitive materials, and ensuring the quality of the granulated product.

[0022] Preferably, the body of the granulator can be made of stainless steel to ensure its hygiene and durability.

[0023] Preferably, the granulator body may include a cooling system to cool the molten material during forming and control the operating temperature of the equipment.

[0024] Preferably, the granulator body may include a screening system for further processing the granules after granulation to further make the granule size more uniform.

[0025] Preferably, the granulator body may include an electrical control system, such as a control panel, sensors, switches, etc., for monitoring and controlling various parameters during the granulation process and making adjustments.

[0026] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0027] 1. The present utility model provides a deoxidation device for preparing a molten solid dispersion of powdery materials. By installing a pipeline on the feeding pipe and introducing a corresponding gas such as an inert gas to displace the oxygen in the materials, and pushing it to the exhaust station to discharge the mixed gas, the oxygen contained in the powdery materials is effectively removed, the influence of oxygen on highly sensitive materials is eliminated, and the quality of the products obtained by granulation is ensured.

[0028] 2. The present utility model provides a granulator. By installing a pipeline on the feeding pipe of the melting granulator and introducing a corresponding gas such as an inert gas to displace the oxygen in the materials, and pushing it to the exhaust station to discharge the mixed gas, the oxygen contained in the powdery materials is effectively removed, the influence of oxygen on highly sensitive materials is eliminated, and the quality of the products obtained by granulation is ensured. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 is a granulator according to the present utility model;

[0030] Figure 2 is a deoxidation device for preparing a molten solid dispersion of powdery materials according to the present utility model;

[0031] Markings in the figures:

[0032] 1 - Granulator body

[0033] 2 - Pipeline

[0034] 3 - Pressure regulating valve group

[0035] 4 - Extrusion driving mechanism

[0036] 5 - Exhaust port

[0037] 6 - Filter

[0038] 7 - Feeding pipe

[0039] 8 - Upper heating body for materials

[0040] 9 - Lower heating body for materials

[0041] 10 - Blanking pipe cleaning port

[0042] 11 - Material inlet

[0043] 12 - Material port Detailed implementation manners

[0044] The following further describes the present utility model in detail with reference to specific embodiments. However, this should not be construed as limiting the scope of the above - mentioned subject matter of the present utility model to the following embodiments. All technologies implemented based on the content of the present utility model belong to the scope of the present utility model.

[0045] In the description of the specific embodiments of the present utility model, without special explanation, the expression terms of the orientation or positional relationship indicated by "upper", "lower", "left", "right", "center", "inner", "outer", etc. are all based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship when the utility model product / device / equipment is commonly used. These terms of orientation or positional relationship are only for the convenience of describing the solution of the present utility model or simplifying the description in specific embodiments, facilitating technicians to quickly understand the solution, rather than indicating or implying that a specific device / component / element must have a specific orientation or be constructed and operated in a specific positional relationship. Therefore, it should not be construed as a limitation to the present utility model.

[0046] In addition, for terms such as "horizontal", "vertical", "hanging", "parallel", etc., it does not mean that the corresponding device / component / element is required to be absolutely horizontal or vertical or hanging or parallel, but can be slightly inclined or have a deviation. For example, "horizontal" only means that its direction is more horizontal relative to "vertical", and does not mean that the structure must be completely horizontal, but can be slightly inclined. Or, it can be simply understood that the corresponding device / component / element is arranged in the directions of "horizontal", "vertical", "hanging", "parallel", etc., and can have an error / deviation of ±10% relative to the corresponding direction setting, more preferably within ±8%, more preferably within ±6%, more preferably within ±5%, more preferably within ±4%. As long as the corresponding device / component / element is within the error / deviation range, it can still perform its function in the solution of the present utility model.

[0047] In addition, the expressions such as "first", "second", "third", etc. in the terms are only used to distinguish the description of the same or similar components, and should not be understood as emphasizing or implying the relative importance of specific components.

[0048] In addition, in the description of the embodiments of the present utility model, "several", "multiple", and "a number of" represent at least two. It can be any case such as 2, 3, 4, 5, 6, 7, 8, 9, etc., and even can be a case of more than 9.

[0049] In addition, in the description of the technical solutions of the present utility model, unless otherwise clearly specified / defined / restricted, where the terms "set", "installed", "connected", "coupled", "provided with", "laid", "arranged" appear, they should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection. It can be connection means commonly used in the art such as welding, riveting, bolting, threaded connection, etc. Such a connection can be a mechanical connection, an electrical connection, or a communication connection; it can be directly connected or indirectly connected through an intermediate medium, and can be the communication inside two components.

[0050] Embodiment 1

[0051] As Figure 1 , Figure 2 shown, Figure 2 is Figure 1 a partially enlarged view of the framed area of a deoxidizing device for preparing a molten solid dispersion of a powdery material, including an extrusion driving mechanism 4, a feeding pipe 7, and a melting cavity. The melting cavity is communicated with a material port 12 and an exhaust port 5. The feeding pipe 7 is installed on the material port 12. A pipe 2 is installed on the feeding pipe 7, and a pressure regulating valve group 3 is arranged on the pipe 2. A filter 6 is arranged on the exhaust port 5.

[0052] The improved device installs a blanking pipe 7 on the material inlet 5, adds a pipeline 2 injection interface on its side wall, and installs a pressure regulating valve group 3 on the pipeline 2. During the production of granulation, the powdery material is fed at a constant speed. The pipeline 2 transports clean inert gas, nitrogen or carbon dioxide, which is introduced into the space to be replaced, that is, the blanking pipe 7 of the present invention, through the pipeline 2 and the pressure regulating valve group 3, and is slowly injected under control and mixed with the material for melt granulation. Based on the principle of gas diffusion, gas diffusion mainly depends on the gas pressure difference. By filling enough gas in the closed space of the blanking pipe 7, the original oxygen in the powdery material can be gradually expelled. This process is accompanied by pressure changes. The extrusion driving mechanism 4 pushes the powdery material and the mixed gas to the exhaust port 5. Due to the pressure change, the mixed gas will be released and discharged. After being filtered by the filter 6 installed at the exhaust station, it is discharged to the operation room and then discharged to the atmospheric environment with the ventilation of the central air conditioner in the operation room, thus completing the deoxidation work of the powdery material during the melt granulation process. Judging from the oxygen quality replacement tests and operating conditions of inert gas or nitrogen after the on-site hardware transformation, the system operates safely and stably. For the test machine materials extruded at the normal production speed of the equipment, the residual oxygen content detection and control of the samples are all around 1% ± 0.05, which has reached the quality standard requirement that the oxygen content required for key drugs is lower than 2%.

[0053] In an optional embodiment, the pipeline 2 and the blanking pipe 7 can be fixedly connected or detachably connected, such as connected in a quick chuck manner, etc., to facilitate disassembly, installation and cleaning.

[0054] In an optional embodiment, the exhaust port 5 and the filter 6 can be detachably connected, and the material inlet 12 and the blanking pipe 7 can be detachably connected, such as bolt connection, standard chuck connection, etc., which is convenient for disassembly and installation.

[0055] In an optional embodiment, the blanking pipe 7 is installed vertically, and the pipeline 2 is obliquely connected to the wall of the blanking pipe 7. After on-site testing, the oblique intersection angle between the two bases is between 40° and 60°. It can slow down the flow rate change of the gas when it is injected into the blanking pipe 7. The oblique intersection connection can effectively guide the gas so that the gas guiding direction is consistent with the material blanking direction, prevent the gas from affecting the normal blanking upwards and reduce the energy loss caused by sudden direction change, improve the gas injection efficiency, and the oblique intersection connection can also reduce the impact of the fluid on the inner wall of the pipeline 2, reducing wear and erosion.

[0056] In an optional embodiment, the pressure regulating valve group 3 is installed on the pipeline 2. Through the pressure regulating valve group 3, the gas inlet flow rate and pressure can be controlled, and the pressure can be adjusted under the detected and indicated pressure values to keep the system within a safe range.

[0057] In an alternative embodiment, the pipe 2 can be bent at the pressure regulating valve group 3 so that the upper air inlet of the pipe 2 is vertically upward, and clean gas is transported to the pipe 2, which can optimize the gas flow direction and improve safety in case of leakage risk.

[0058] In an alternative embodiment, a cleaning port 10 for the blanking pipe can be provided at the top of the blanking pipe 7, which is convenient for cleaning the blanking pipe 7 to ensure smoothness, prevent excessive pressure caused by material blockage, and extend the service life of the equipment.

[0059] In an alternative embodiment, a material inlet 11 can be provided on the side wall of the top of the blanking pipe 7 for feeding materials into the blanking pipe 7.

[0060] In an alternative embodiment, the pipe 2 can be a pipe fitting with high rigid strength such as seamless stainless steel material, which has strong corrosion resistance and is not damaged during long-term use in material and medicine production, extending the life of the pipe 2. And seamless pipe fittings show stable and reliable performance under high pressure, reducing the risks of leakage and explosion.

[0061] In an alternative embodiment, the material extrusion driving mechanism 4 includes an extrusion screw and a motor. Under the drive of the motor, the shear force and thrust generated by the rotation of the extrusion screw push the material forward and granulate.

[0062] In an alternative embodiment, the extrusion screw can be a spiral die, a plunger or a pressure roller, etc. The spiral die helps to evenly mix the materials, improve the consistency of product quality, and the rotating propulsion function can promote the melting of the materials and improve production efficiency.

[0063] In an alternative embodiment, a melting cavity can be formed between the upper material heating body 8 and the lower material heating body 9. The upper material heating body 8 and the lower material heating body 9 can both be installed with electric heating tubes, heating plates and electrical control systems, etc., for providing heat to heat the material above its melting point to melt the solid material to achieve the purpose of melt granulation.

[0064] In an alternative embodiment, the upper material heating body 8 and the lower material heating body 9 can be made of 316 stainless steel material to meet the requirements of the GMP specification in the pharmaceutical industry, eliminate the quality risk of material pollution, and have the characteristics of high strength and corrosion resistance.

[0065] In an alternative embodiment, the lower material heating body 9 is fixed, and the upper material heating body 8 can be lifted upward to open, so as to facilitate the disassembly and installation of the extrusion screw in the cavity and clean the melting cavity.

[0066] In an alternative embodiment, the distance between the exhaust port 5 at the exhaust station and the blanking pipe 7 can be set as required during the design and manufacture of the equipment. In this embodiment, the distance is 120 mm. If necessary, it can be improved during manufacturing to discharge the mixed gas at the initial stage of the melting granulation process and reduce the possibility of material oxidation in a high-temperature environment.

[0067] In an alternative embodiment, the components for filtering gas inside the filter 6 can be a standard food-grade filter element, membrane filter, catalyst bed, etc. The filter 6 can filter the waste gas and discharge it to the operation room, not only avoiding environmental pollution but also ensuring the health and safety of the workshop and personnel.

[0068] Embodiment 2

[0069] This embodiment provides a granulator, as Figure 1 and Figure 2 shown, which includes a granulator body 1 and an oxygen removal device for preparing a molten solid dispersion of a powdery material as in Embodiment 1.

[0070] In an alternative embodiment, the body of the granulator body 1 can be made of stainless steel to ensure its hygiene and durability.

[0071] In an alternative embodiment, the granulator body 1 can include a cooling system to cool the molten material during molding and control the working temperature of the equipment.

[0072] In an alternative embodiment, the granulator body 1 can include a screening system for further processing the granules after granulation to further make the granule size more uniform.

[0073] In an alternative embodiment, the granulator body 1 can include an electrical control system, such as a control panel, sensors, switches, etc., for monitoring and controlling various parameters during the granulation process and making adjustments.

[0074] In an alternative embodiment, the granulator can be applicable to powdery materials, granular materials, paste materials, etc. that are sensitive to oxygen and need to be deoxygenated during the granulation process, and can effectively remove oxygen during the melting granulation production process.

[0075] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An oxygen removal device for preparing a molten solid dispersion of powdery materials, comprising: A material extrusion driving mechanism (4), a blanking pipe (7) and a melting cavity, characterized in that the melting cavity is communicated with a material inlet (12) and an exhaust port (5), the blanking pipe (7) is installed on the material inlet (12), a pipe (2) is installed on the blanking pipe (7), a pressure regulating valve group (3) is arranged on the pipe (2), and a filter (6) is arranged on the exhaust port (5).

2. The deoxidation device for preparing a molten solid dispersion of powdery materials according to claim 1, characterized in that, The blanking pipe (7) is vertically installed, and the pipe (2) is obliquely connected to the wall of the blanking pipe (7).

3. The deoxidation device for preparing a molten solid dispersion of powdery materials according to claim 2, characterized in that, The pipe (2) is bent at the pressure regulating valve group (3), and the air inlet at the upper part of the pipe (2) is vertically upward.

4. The deoxidation device for preparing a molten solid dispersion of powdery materials according to claim 3, characterized in that, A blanking pipe cleaning port (10) is arranged at the top of the blanking pipe (7).

5. The deoxygenation device for preparing a molten solid dispersion of powdery materials according to claim 4, characterized in that, A material feed inlet (11) is arranged on the side wall at the top of the blanking pipe (7).

6. The deoxygenation device for preparing the molten solid dispersion of powdery materials according to claim 1, characterized in that, The pipe (2) is a seamless stainless steel pipe fitting.

7. The deoxidation device for preparing a molten solid dispersion of powdery materials according to claim 1, wherein, The material extrusion driving mechanism (4) comprises an extrusion screw and a motor.

8. An oxygen removal device for preparing a molten solid dispersion of a powdery material according to any one of claims 1-7, characterized in that, It further comprises a material upper heating body (8) and a material lower heating body (9), the melting cavity is formed between the material upper heating body (8) and the material lower heating body (9), and electric heating pipes are installed on both the material upper heating body (8) and the material lower heating body (9).

9. The deoxidization device for preparing the molten solid dispersion of powdery materials according to claim 8, characterized in that, The material upper heating body (8) is openable, and the material lower heating body (9) is fixed.

10. A granulator, characterized in that, It includes a granulator body (1) and a deoxidation device for preparing a molten solid dispersion of a powdery material as described in any one of claims 1-9.

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