Antibody protein purification device

Abstract

The utility model discloses an antibody protein purification device which comprises a base and a vertical rod fixedly arranged on the base, a sliding sleeve capable of sliding up and down along the vertical rod is arranged on the vertical rod, a connecting seat is arranged on the sliding sleeve, a supporting disc is arranged on the connecting seat, and an automatic clamping mechanism is arranged on the supporting disc. The automatic clamping mechanism comprises a positioning sleeve, the positioning sleeve is arranged on the supporting disc, and clamping structures for automatically fixing the purification test tubes with different diameters are annularly and uniformly arranged in the positioning sleeve; the clamping structure comprises an inclined clamping plate, a rotating shaft is arranged at one end of the clamping plate, a mounting frame is arranged on the inner wall of the positioning sleeve, the rotating shaft is connected with the mounting frame through a torsional spring, and the rotating shaft can rotate relative to the mounting frame. According to the purification test tube fixing device, purification test tubes with different diameters can be quickly fixed, and the purification test tubes can be fixed in an auxiliary manner, so that the purification test tubes are prevented from slipping off and being damaged during installation.

Description

Technical Field

[0001] The utility model belongs to the technical field of biological experiments, and particularly relates to an antibody protein purification device. Background Technique

[0002] At present, in the field of biological experiments, proteins need to be prepared for the diagnosis of various body indicators and the treatment of various diseases. Since a large number of different candidate proteins need to be screened and tested during the R & D process to determine the best protein, relevant proteins need to be purified. To meet the actual application requirements, a purification device is used to complete the high-throughput purification of proteins.

[0003] Due to the different specifications of purification test tubes, with different diameters and lengths, the current purification devices (such as a new type of protein antibody purification device with the authorization announcement number CN218665851U) cannot quickly clamp and fix purification test tubes with different diameters at one time during use. The clamping and fixing operation of purification test tubes is cumbersome. At the same time, during the clamping process of purification test tubes, purification test tubes with different specifications cannot be carried, and it is easy for the purification test tubes to slip and be damaged during clamping, affecting the smooth progress of purification. Therefore, we propose to develop a new antibody protein purification device. Summary of the Invention

[0004] The purpose of the utility model is to provide an antibody protein purification device to solve the problems raised in the above background technique. Due to the different specifications of purification test tubes, with different diameters and lengths, the current purification devices cannot quickly clamp and fix purification test tubes with different diameters at one time during use. The clamping and fixing operation of purification test tubes is cumbersome. At the same time, during the clamping process of purification test tubes, purification test tubes with different specifications cannot be carried, and it is easy for the purification test tubes to slip and be damaged during clamping, affecting the progress of purification.

[0005] To achieve the above purpose, the utility model provides the following technical solutions:

[0006] An antibody protein purification device, including a base and a vertical rod fixedly arranged on the base. Among them,

[0007] A sliding sleeve that can slide up and down along the vertical rod is arranged on the vertical rod. A connecting seat is arranged on the sliding sleeve. A support plate is arranged on the connecting seat. An automatic clamping mechanism is arranged on the support plate.

[0008] The automatic clamping mechanism includes a positioning sleeve which is arranged on a support disk, and a clamping structure for automatically fixing purification test tubes with different diameters is evenly arranged in a circular shape inside the positioning sleeve; the clamping structure includes a clamping plate which is inclined, one end of the clamping plate is provided with a rotating shaft, an installation frame is arranged on the inner wall of the positioning sleeve, the rotating shaft is connected with the installation frame through a torsion spring, and the rotating shaft can rotate relative to the installation frame;

[0009] A bearing mechanism for supporting purification test tubes with different lengths is further arranged on the connecting seat.

[0010] In one embodiment, an arc-shaped clamping part is arranged at one end of the clamping plate, and the arc-shaped clamping part and the clamping plate are of an integrally formed structure and can be closely attached to purification test tubes with different specifications.

[0011] In one embodiment, an anti-slip rubber pad is inlaid on one side of the arc-shaped clamping part, which increases the friction between the arc-shaped clamping part and the purification test tube and further improves the stability of clamping the purification test tube.

[0012] In one embodiment, the bearing mechanism includes a bearing disk corresponding to the support disk, and the bearing disk is arranged on a bearing seat; an adjusting rod is arranged on the bearing seat, an adjusting opening is arranged on the connecting seat, one end of the adjusting rod is movably arranged on the adjusting opening, and a self-locking structure for locking the height of the adjusting rod is arranged on the connecting seat, so that the height of the bearing disk can be adjusted to facilitate the bearing of purification test tubes with different lengths.

[0013] In one embodiment, the self-locking structure includes an adjusting rack which is arranged on the adjusting rod, a transverse installation hole is further arranged on the adjusting opening, a locking rod is further arranged in the transverse installation hole, a clamping pin is arranged at one end of the locking rod, and the clamping pin is clamped in the corresponding tooth of the adjusting rack, so that the position of the adjusting rod can be automatically locked to facilitate the rapid adjustment of the height of the bearing disk.

[0014] In one embodiment, a return spring is sleeved on the locking rod, and the return spring is used for resetting the locking rod.

[0015] In one embodiment, a test tube positioning groove corresponding to the positioning sleeve is further arranged on the bearing disk to facilitate the positioning of the bottom of the purification test tube.

[0016] In one embodiment, a positioning bolt is further arranged on the sliding sleeve, and one end of the positioning bolt abuts against the vertical rod, so that the position of the sliding sleeve can be locked to facilitate the adjustment of the height of the support disk.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] (1)The utility model can quickly fix purification test tubes with different diameters, change the original cumbersome situation of fixing purification test tubes, and improve the purification efficiency.

[0019] (2)When installing purification test tubes with different lengths, the utility model can assist the purification test tubes to prevent the situation of slipping and breaking during the installation of the purification test tubes. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 is a schematic structural diagram of the utility model.

[0021] Figure 2 is a schematic semi-sectional structural diagram of the automatic clamping mechanism in the utility model.

[0022] Figure 3 is Figure 2 an enlarged structural diagram of part A in

[0023] Figure 4 is a schematic structural diagram of the clamping plate in the utility model.

[0024] Figure 5 is a schematic structural diagram of the bearing mechanism in the utility model.

[0025] Figure 6 is a schematic semi-sectional structural diagram of the connecting seat in the utility model.

[0026] Figure 7 is Figure 6 an enlarged structural diagram of part B in DETAILED DESCRIPTION OF THE EMBODIMENTS

[0027] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments in the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0028] Please refer to Figures 1-3 , the present utility model provides an antibody protein purification device, including an automatic clamping mechanism 1, the automatic clamping mechanism 1 is arranged on a support plate 2, the support plate 2 is arranged on a connecting seat 8, the connecting seat 8 is arranged on a sliding sleeve 7, the sliding sleeve 7 is movably arranged on a vertical rod 5, and the vertical rod 5 is set on a base 4.

[0029] The automatic clamping mechanism 1 includes a positioning sleeve 11 which is arranged on the support disk 2. A clamping structure for automatically fixing purification test tubes with different diameters is evenly arranged in a ring shape inside the positioning sleeve 11. The clamping structure includes a clamping plate 12 arranged obliquely. One end of the clamping plate 12 is provided with a rotating shaft 13. The rotating shaft 13 is rotatably arranged on the mounting frame 14, and the rotating shaft 13 is connected to the mounting frame 14 through a torsion spring 15. The mounting frame 14 is arranged on the inner wall of the positioning sleeve 11.

[0030] When installing the purification test tube, insert the purification test tube into the positioning sleeve 11 and push the purification test tube downward. After the top of the purification test tube fits with multiple groups of clamping plates 12, as the purification test tube moves, multiple groups of clamping plates 12 can be simultaneously pushed to unfold. The multiple groups of clamping plates 12 drive the rotating shaft 13 to rotate in the mounting frame 14. The rotation of the rotating shaft 13 can drive the torsion spring 15 to rotate. When the purification test tube is completely clamped into the positioning sleeve 11, the torsion spring 15 rebounds to drive the clamping plate 12 to rotate back, so that the clamping plate 12 can be closely attached to the surface of the purification test tube, quickly fixing the purification test tube. Through the unfolding and automatic reset of multiple groups of clamping plates 12, purification test tubes with different diameters can be clamped and fixed.

[0031] Please refer to Figure 4 , one end of the clamping plate 12 is provided with an arc-shaped clamping part 16. The arc-shaped clamping part 16 and the clamping plate 12 are of an integrally formed structure and can be closely attached to purification test tubes of different specifications. An anti-slip rubber pad 17 is inlaid on one side of the arc-shaped clamping part 16, increasing the friction between the arc-shaped clamping part 16 and the purification test tube, and further improving the stability of clamping the purification test tube.

[0032] In one embodiment, please refer to Figures 5-7, a bearing mechanism 3 for supporting purification test tubes of different lengths is provided on the connecting seat 8. The bearing mechanism 3 includes a bearing disc 301 corresponding to the support disc 2. The bearing disc 301 is arranged on the bearing seat 303. An adjusting rod 306 is arranged on the bearing seat 303. The adjusting rod 306 is movably arranged in the adjusting opening 307. The adjusting opening 307 is arranged on the connecting seat 8. A self-locking structure for locking the height of the adjusting rod 306 is provided on the connecting seat 8, which can adjust the height of the bearing disc 301 to facilitate the bearing of purification test tubes of different lengths. The self-locking structure includes an adjusting rack 304 arranged on the adjusting rod 306. A transverse mounting hole 310 is also provided on the adjusting opening 307. A locking rod 308 is also arranged in the transverse mounting hole 310. A latch 309 is arranged at one end of the locking rod 308. The latch 309 is clamped in the corresponding tooth of the adjusting rack 304, which can automatically lock the position of the adjusting rod 306 to facilitate the rapid adjustment of the height of the bearing disc 301. A return spring 311 is sleeved on the locking rod 308. One end of the return spring 311 is connected to the locking rod 308, and the other end is connected to the transverse mounting hole 310. Through the elastic force of the return spring 311, the locking rod 308 can be reset and moved.

[0033] When installing purification test tubes of different lengths, according to the length of the purification test tube, adjust the height of the bearing disc 301. Push the bearing disc 301 upward. The bearing disc 301 drives the adjusting rod 306 to move upward in the adjusting opening 307. The adjusting rod 306 drives the adjusting rack 304 to move upward. The upward movement of the adjusting rack 304 drives the latch 309 to move. The movement of the latch 309 drives the locking rod 308 to move in the transverse mounting groove. The movement of the locking rod 308 compresses the return spring 311. When the bottom of the bearing disc 301 fits with the bottom of the purification test tube, the bearing disc 301 can support the purification test tube. At the same time, the return spring 311 drives the locking rod 308 to reset and move. The locking rod 308 drives the latch 309 to reset and move, and clamps the latch 309 into the tooth of the corresponding adjusting rack 304 to position the adjusting rod 306. At the same time, the height of the bearing disc 301 is adjusted to meet the bearing of purification test tubes of different lengths and prevent damage caused by slipping during the installation process.

[0034] Furthermore, a limit plate 305 is also arranged at the end of the adjusting rod 306, which can prevent the adjusting rod 306 from moving out of the adjusting opening 307 and limit the movement stroke of the adjusting rod 306.

[0035] Furthermore, test tube positioning grooves 302 corresponding to the positioning sleeves 11 one by one are also provided on the bearing disc 301 to facilitate the positioning of the bottom of the purification test tube.

[0036] Further, the sliding sleeve 7 is also provided with a positioning bolt 6. One end of the positioning bolt 6 abuts against the vertical rod 5. When the sliding sleeve 7 is moved, the sliding sleeve 7 moves along the vertical rod 5. At the same time, the sliding sleeve 7 drives the support disc 2 to move. Then, the sliding sleeve 7 is fixed by the positioning bolt 6, and the position of the sliding sleeve 7 can be locked, which is convenient for adjusting the height of the support disc 2.

[0037] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An antibody protein purification device, characterized in that, It includes a base and a vertical rod fixedly arranged on the base. A sliding sleeve is arranged on the vertical rod and can slide up and down along the vertical rod. A connecting seat is arranged on the sliding sleeve, a support plate is arranged on the connecting seat, and an automatic clamping mechanism is arranged on the support plate. The automatic clamping mechanism includes a positioning sleeve arranged on the support plate. A clamping structure for automatically fixing purification test tubes of different diameters is evenly arranged in a ring shape in the positioning sleeve. The clamping structure includes a clamping plate arranged obliquely. One end of the clamping plate is provided with a rotating shaft. An installation frame is arranged on the inner wall of the positioning sleeve. The rotating shaft is connected to the installation frame through a torsion spring, and the rotating shaft can rotate relative to the installation frame. A bearing mechanism for supporting purification test tubes of different lengths is also arranged on the connecting seat.

2. The antibody protein purification device according to claim 1, characterized in that, An arc-shaped clamping portion is arranged at one end of the clamping plate, and the arc-shaped clamping portion and the clamping plate are integrally formed.

3. The antibody protein purification device according to claim 2, wherein, An anti-slip rubber pad is inlaid on one side of the arc-shaped clamping portion.

4. The antibody protein purification device according to claim 1, characterized in that, The bearing mechanism includes a bearing plate corresponding to the support plate, and the bearing plate is arranged on a bearing seat. An adjusting rod is arranged on the bearing seat, an adjusting opening is arranged on the connecting seat, one end of the adjusting rod is movably arranged in the adjusting opening, and a self-locking structure for locking the height of the adjusting rod is arranged on the connecting seat.

5. The antibody protein purification device according to claim 4, wherein The self-locking structure includes an adjusting rack arranged on the adjusting rod. A transverse installation hole is also arranged on the adjusting opening, and a locking rod is arranged in the transverse installation hole. A latch is arranged at one end of the locking rod, and the latch is clamped in the corresponding tooth of the adjusting rack.

6. The antibody protein purification device according to claim 5, wherein A return spring is sleeved on the locking rod, and the return spring is used for resetting the locking rod.

7. The antibody protein purification device according to claim 4, wherein: Tube positioning grooves corresponding to the positioning sleeves one by one are also arranged on the bearing plate.

8. The antibody protein purification device according to any one of claims 1-7, characterized in that, A positioning bolt is also arranged on the sliding sleeve, and one end of the positioning bolt abuts against the vertical rod.

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