Ultrafiltration cup and ultrafiltration system
By setting the return port under the side wall of the cup body in the ultrafiltration cup and close to the flow guide, the problems of droplet splashing and protein components are solved, and the liquid flows smoothly and discharges quickly are achieved, improving the effect of material liquid treatment.
Patent Information
- Application Number
- CN202422133862.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-31
- Publication Date
- 2025-07-18
- Estimated Expiration
- 2034-08-31
AI Technical Summary
The existing ultrafiltration cups are prone to splashing droplets, protein components inactivation and bubbles during the rehydration and reflux process, resulting in a decrease in the processing efficiency of the liquid.
The return port is arranged on the side wall of the cup body, located below the liquid replenishment port, and close to the flow guide. The liquid flows along the inner wall of the cup body to reduce impact, and the return liquid is quickly discharged to avoid deposition.
It reduces droplet splash and bubble generation, protects protein components activity, and improves the processing efficiency of the feed liquid and dialysis efficiency.
Smart Images
Figure CN223112790U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of filtration, in particular to an ultrafiltration cup and an ultrafiltration system. Background Art
[0002] The ultrafiltration system generally includes an ultrafiltration cup connected between a front-end container and an ultrafiltration membrane package, and the ultrafiltration cup is generally used for circulating feed liquid.
[0003] The existing ultrafiltration cup generally includes a cup body and a cup cover, wherein the cup body includes a cup body, a flow guide and a support, and the cup cover is installed at the open top of the cup body. The flow guide is arranged between the cup body and the support, and the cup body and the flow guide form a fluid channel interconnected with each other.
[0004] Usually, there are three joints on the cup cover, which are used to balance the internal and external air pressure, replenishment and downstream liquid circulation reflux. That is to say, the replenishment and downstream liquid circulation reflux are injected vertically downward from the cup cover, and the replenishment and reflux liquid will impact the liquid in the cup body during the process of direct vertical downward injection, forming droplets splashing, and the violent flow impact and impact will also cause the protein components in the feed liquid to be inactivated and generate a large number of bubbles.
[0005] In view of the above problems, the location of the refill port or reflux port of the ultrafiltration cup needs to be improved to solve the problems of droplet splashing, protein component inactivation and bubbles generated during the refill process of the ultrafiltration cup or the process of downstream liquid circulating back to the ultrafiltration cup. Utility Model Content
[0006] In order to overcome the shortcomings of the prior art, the utility model provides an ultrafiltration cup and an ultrafiltration system, which sets the reflux port on the side wall of the cup body and is located below the liquid infusion port, so as to reduce the splashing of droplets, inactivation of liquid protein and generation of bubbles caused by the violent flow impact of the liquid.
[0007] The technical solution adopted by the utility model to solve its technical problems is:
[0008] An ultrafiltration cup, comprising:
[0009] The cup body at least comprises a cup body, a guide portion formed at the bottom of the cup body, and a drainage area formed at one end of the guide portion away from the cup body, wherein a side wall of the drainage area is provided with an outlet;
[0010] A cup cover is detachably and sealedly arranged on the top of the cup body;
[0011] The cup body or the cup cover has a liquid replenishing port located above the outlet;
[0012] The side wall of the cup body is provided with at least one reflux port for communicating the outside and the inside of the cup body, and the reflux port is closer to the diversion part than the liquid supplement port.
[0013] In the present utility model, the reflux port is arranged on the side wall of the cup body. Compared with the prior art in which the reflux port is arranged on the cup cover, arranging the reflux port on the side wall of the cup body enables the reflux liquid to flow downward along the inner wall of the cup body after entering the cup body. The inner wall of the cup body plays a role in guiding the flow. Under the guiding action of the inner wall of the cup body, the liquid will not impact the liquid in the cup to form liquid droplets splashing, and the flow impact of the liquid is alleviated, the liquid flow rate is smoother, preventing the occurrence of violent flow impact or collision of the liquid, thereby reducing the possibility of inactivation of the protein component in the feed liquid. At the same time, the small liquid impact force can also reduce the generation of bubbles.
[0014] The reflux port is closer to the diversion part than the liquid supplement port, that is, the reflux port is located below the liquid supplement port. First, the solid content of the reflux liquid injected into the cup from the reflux port is higher than that of the feed liquid transported through the liquid supplement port. It is easy to form further deposition when staying in the cup body for a long time, resulting in an increase in the solid content of the bottom material and an increase in the liquid inlet pressure. When the downstream of the ultrafiltration cup is a dialysis operation, the deposition of the bottom material will also lead to a reduction in dialysis efficiency and even cause the feed liquid to be stratified. By setting the reflux port closer to the diversion part, it is beneficial for the reflux liquid to be discharged through the outlet faster, shortening the residence time of the reflux liquid in the cup body and preventing deposition; secondly, setting the reflux port below the liquid supplement port enables the reflux liquid to directly mix with the liquid in the cup body after entering the cup body, or to merge into the liquid in the cup body at an acute angle to the horizontal plane in a short time and mix with the liquid in the cup body. The flow impact and collision of the liquid basically no longer occur, preventing liquid droplets from splashing and reducing the possibility of bubble generation, and better protecting the activity of the protein component.
[0015] Further, the height of the cup body is H, and the axial distance between the reflux port and the bottom of the cup body is not greater than 1 / 2H.
[0016] In the actual application scenario, the liquid level in the cup generally is above half of the height of the cup body. Therefore, by setting the reflux port at half of the height of the cup body or below half of the height, after the reflux liquid is injected into the cup from the reflux port, it directly mixes with the liquid in the cup body, and even does not require the reflux liquid to flow downward along the inner wall of the cup body. The flow impact and collision of the liquid are directly absorbed by the liquid in the cup body, and no bubbles are generated, and the activity of the protein component is better protected.
[0017] Further, the reflux port is located at the bottom of the cup body and is adjacent to the starting end of the diversion part.
[0018] With such a setting, the lowest point of the liquid level at the reflux port is adjacent to the maximum inner diameter of the diversion part. Since the concentration of the reflux liquid flowing into the reflux port is relatively higher, that is, the solid content of this liquid is higher, the reflux liquid staying in the cup body for a long time is likely to form further deposition, resulting in an increase in the solid content of the bottom material and an increase in the pressure of the incoming liquid. In addition, when the downstream of the ultrafiltration cup is a dialysis operation, the deposition of the material in the cup body will lead to a decrease in dialysis efficiency and even cause stratification of the feed liquid. Therefore, the reflux port is located at the bottom of the cup body main body and adjacent to the diversion part, enabling the reflux liquid flowing into the reflux port to be discharged again more quickly, avoiding the deposition of the bottom material, preventing the stratification of the feed liquid, and reducing the incoming liquid pressure. At the same time, the reflux port is located at the bottom of the cup body main body. Even when the volume of the liquid in the cup body is very small, the reflux liquid can flow along the inner wall of the diversion part and mix with the liquid in the cup body in a short time, achieving the purpose of reducing the impact of fluid flow, avoiding the splashing of liquid droplets, preventing the generation of bubbles, and better protecting the activity of the protein component.
[0019] Further, the reflux port includes a first reflux port located at the bottom of the cup body main body and a second reflux port located at half of the height of the cup body main body.
[0020] With such a setting, the reflux liquid is divided into two streams and is respectively transported into the cup body from the first reflux port and the second reflux port. While achieving the effect of the reflux port being at the bottom of the cup body, the flow rates of the two reflux liquids are lower respectively, the impact force of the reflux liquid flow is dispersed, and the flow impact and collision of the liquid basically no longer occur, and the activity of the protein component is better protected.
[0021] Further, the central axis of the reflux port and the central axis of the outlet are located in the same axial plane.
[0022] When the reflux port and the outlet are on the same side of the same axial plane, the distance between the reflux port and the outlet is relatively close, the flow distance of the reflux liquid between the reflux port and the outlet is the shortest, and the reflux liquid can be quickly discharged outwards again, avoiding the deposition of the feed liquid, preventing the stratification of the feed liquid, and improving the dialysis efficiency. When the reflux port and the outlet are on the opposite sides of the same axial plane, the liquid injected into the reflux port does not need to turn and directly flows towards the outlet direction, which is conducive to the quick re - discharge of the reflux liquid.
[0023] Further, a maximum volume indication part of the cup body is provided on the side wall of the cup body main body, and the liquid supplement port is located on the side wall of the cup body main body, and its central axis is not lower than the maximum volume indication part.
[0024] In most actual application scenarios, the liquid in the cup body is maintained at or near the height of the maximum volume indicating portion, and the central axis of the liquid replenishing port is higher than the maximum volume indicating portion. This can not only prevent the liquid in the cup body from being sucked back into the front liquid container, but also enable the liquid input from the liquid replenishing port to quickly mix with the liquid in the cup body. The flow impact and collision of the liquid basically no longer occur, preventing liquid droplets from splashing and reducing the possibility of bubble generation, and better protecting the activity of the protein component.
[0025] Further, the guiding portion is conical, and its inner diameter gradually decreases from the bottom end of the cup body main body to the liquid discharge area, and the inclination angle of its side wall is 7-12°.
[0026] If the α angle is less than 7°, the inclination angle of the guiding portion is too small. When aggregates are formed in the liquid in the cup body, the aggregates cannot quickly enter the liquid discharge area through the guiding portion and may even stay in the guiding portion. The guiding portion cannot play a good guiding role, which is not conducive to the smooth discharge of the liquid through the outlet; if the α angle is greater than 12°, the inclination angle of the guiding portion is too large, resulting in relatively intense fluid flow impact when the liquid flows from the guiding portion to the liquid discharge area, which in turn causes the protein component in the liquid to be inactivated, and it is also easy to generate a large number of bubbles. Moreover, the inner diameter of the liquid discharge area is relatively large. When too much liquid accumulates in the liquid discharge area, the liquid in the liquid discharge area cannot be fully stirred by the magnetic stirring rotor, and there is also a risk of local deposition, which has an adverse impact on the discharge of the liquid through the outlet; furthermore, when the α angle is greater than 12°, the larger inner diameter of the liquid discharge area leads to an increase in its volume. At this time, it is necessary to increase the magnetic stirring force to evenly disperse the liquid. Once the stirring force is too large, it is easy to cause the inactivation of the liquid protein, and the activity of the protein component cannot be protected.
[0027] Further, the volume of the liquid discharge area is 1-3% of the maximum volume of the cup body; and / or, the axial distance between the lowest part of the outlet and the bottom wall of the liquid discharge area is not greater than 1 mm.
[0028] Since the protein component in the liquid is easily inactivated, if the volume of the liquid discharge area is greater than 3% of the maximum volume of the cup body, the volume of the liquid discharge area is too large, resulting in an increased possibility of inactivation of the protein component because too much liquid in the cup body is in a stirred state. Moreover, when there is more liquid in the liquid discharge area, it is necessary to increase the magnetic stirring force to evenly disperse the liquid. Once the stirring force is too large, it is easy to cause the inactivation of the liquid protein, and the activity of the protein component cannot be protected; in addition, when the volume of the liquid discharge area is not greater than 3% of the maximum volume of the cup body, it can also reduce the residue of the liquid;
[0029] If the volume of the discharge area is less than 1% of the maximum volume of the cup body, the volume of the discharge area is too small, the feed liquid stays in the discharge area for too short a time, and the feed liquid in the cup body may be discharged from the outlet without being stirred, which is not conducive to the effective treatment of the feed liquid by the ultrafiltration membrane package; in addition, the small volume of the discharge area will cause inconvenience in its processing and manufacturing, especially it is difficult to form an outlet on the side wall of the discharge area; in addition, the volume of the discharge area is too small, and its built-in magnetic stirring rotor may form excessive stirring force, which is also likely to increase the possibility of protein component inactivation;
[0030] Within the above ratio range, the stirring force in the discharge area is relatively mild, the possibility of inactivation of protein components is reduced, and it can ensure that the liquid at the bottom of the cup body does not settle.
[0031] The axial spacing between the lowest point of the outlet and the bottom wall of the discharge area is less than or equal to 1 mm. At this time, the processing difficulty of the outlet is reduced, which facilitates the manufacture of the cup body and can avoid the accumulation of liquid in the discharge area to the greatest extent, discharge the liquid as much as possible, and reduce the residual liquid in the discharge area.
[0032] Furthermore, the cup cover is also provided with an air pressure balancing port for balancing the air pressure inside and outside the cup body; and / or, the cup cover is provided with a liquid replenishing joint, which has a hose connecting portion extending toward the inner side of the cup body.
[0033] The air pressure balance port is used to balance the internal and external air pressure of the cup body to avoid too low pressure in the cup body and ensure that the material and liquid in the cup body can be discharged smoothly; a liquid replenishment joint is arranged on the cup cover, and the hose connection part formed by it can be connected to the hose, and the hose can be inserted below the liquid surface in the cup body. For working conditions with relatively large liquid replenishment flow, the liquid replenishment is directly mixed with the liquid in the cup body through the liquid replenishment joint and the hose, and the fluid impact is absorbed by the liquid, which can effectively prevent droplet splashing, reduce the possibility of inactivation of protein components, and avoid the generation of bubbles. Moreover, since the liquid replenishment flow is large, the risk of back suction of the material and liquid in the cup body can be eliminated.
[0034] Furthermore, the drainage area is provided with a mounting bottom at one end away from the cup body, which includes a pair of fan-shaped seat bodies with an outer diameter not less than the outer diameter of the cup body, and an assembly portion extending radially outward from the outer wall of each fan-shaped seat body. The pair of fan-shaped seat bodies are radially opposite to each other and staggered circumferentially with the outlet.
[0035] Such an arrangement will not affect the connection operation between the outlet and the external pipe, avoid interference between the external pipe and the fan-shaped seat, and ensure the stability of the cup body placement.
[0036] The utility model also discloses an ultrafiltration system, comprising:
[0037] An ultrafiltration cup as described above;
[0038] A container is connected to the liquid replenishing port of an ultrafiltration cup through a first pipeline and is used for storing the liquid to be processed;
[0039] An ultrafiltration membrane module is connected to the outlet and the reflux port of the ultrafiltration cup through a second pipeline and a third pipeline respectively, and is used for processing the liquid output from the ultrafiltration cup. The liquid before the membrane of the ultrafiltration membrane module returns to the ultrafiltration cup through the third pipeline.
[0040] During the liquid processing of the above ultrafiltration system, the liquid in the container is injected into the cup body through the first pipeline and the liquid replenishing port. The liquid in the cup body is transported to the ultrafiltration membrane module through the outlet and the second pipeline. Among them, the liquid before the membrane returns to the cup body through the third pipeline and the reflux port. Since the reflux port is arranged on the side wall of the cup body main body and is closer to the diversion part than the liquid replenishing port, when the reflux liquid is injected, there will be no violent impact of the liquid, the possibility of liquid droplet splashing is reduced, the possibility of inactivation of the protein component in the liquid is reduced, and the generation of bubbles is reduced.
[0041] The beneficial effects of the present utility model are as follows: The reflux port is arranged on the side wall of the cup body main body, so that after the reflux liquid enters the cup body, it can flow downward along the inner wall of the cup body main body. The inner wall of the cup body main body plays a role in guiding the flow. The liquid will not impact the liquid in the cup body to form liquid droplet splashing, and the flow impact of the liquid is alleviated, the liquid flow rate is smoother, preventing the occurrence of violent flow impact or collision of the liquid, thereby reducing the possibility of inactivation of the protein component in the liquid. At the same time, the small liquid impact force can also reduce the generation of bubbles; The reflux port is arranged below the liquid replenishing port, which is beneficial for the reflux liquid to be discharged through the outlet faster, shortening the time for the reflux liquid to stay in the cup body and preventing deposition; Secondly, setting the reflux port below the liquid replenishing port enables the reflux liquid to directly mix with the liquid in the cup body after entering the cup body, or to flow into the liquid in the cup body at an acute angle to the horizontal plane within a short time and mix with the liquid in the cup body quickly. The flow impact and collision of the liquid basically no longer occur, preventing liquid droplet splashing and reducing the possibility of bubble generation, and better protecting the activity of the protein component.
[0042] In an actual application scenario, the liquid level in the cup body is generally above half of the height of the cup body proper. Therefore, when the reflux port is set at half of the height of the cup body proper or below half of the height, after the reflux liquid is injected into the cup body through the reflux port, it directly mixes with the liquid in the cup body. Even without the reflux liquid flowing down along the inner wall of the cup body, the impact and collision of the liquid flow are directly absorbed by the liquid in the cup body, and no bubbles are generated, so the activity of the protein component is better protected. The reflux port is located at the bottom of the cup body proper and adjacent to the diversion part, so that the reflux liquid flowing in through the reflux port can be discharged again more quickly, avoiding the deposition of bottom materials, preventing the layering of the liquid material, and reducing the inlet liquid pressure. At the same time, even when the volume of the liquid in the cup body is very small, the reflux liquid can flow along the inner wall of the diversion part and mix with the liquid in the cup body in a short time, achieving the purpose of reducing the impact of fluid flow, avoiding liquid droplet splashing, preventing bubble generation, and better protecting the activity of the protein component. BRIEF DESCRIPTION OF THE DRAWINGS
[0043] Figure 1 is the front view of the cup body proper of the ultrafiltration cup in the present invention Figure 1 , at this time, the reflux port is located below the liquid supplement port and above half of the height of the cup body proper.
[0044] Figure 2 is the front view of the cup body proper of the ultrafiltration cup in the present invention Figure 2 , at this time, the reflux port is located below the liquid supplement port and below half of the height of the cup body proper.
[0045] Figure 3 is the front view of the cup body proper of the ultrafiltration cup in the present invention Figure 3 , at this time, the reflux port includes a first reflux port and a second reflux port.
[0046] Figure 4 is the front view of the cup body proper of the ultrafiltration cup in the present invention Figure 4 , at this time, the reflux port is located at the bottom of the cup body proper.
[0047] Figure 5 is the bottom view of the ultrafiltration cup in the present invention.
[0048] Figure 6 is Figure 5 the A-A cross-sectional view in
[0049] Figure 7 is the cross-sectional view of the cup cover in the present invention, at this time, the cup cover is only provided with an air pressure balance port.
[0050] Figure 8 is the front view of the cup cover in the present invention, at this time, the cup cover is provided with an air pressure balance port and a liquid supplement joint.
[0051] Figure 9 isFigure 8 Cross-sectional view of the medium cup lid.
[0052] Figure 10 This is a simplified diagram of the ultrafiltration system in the present invention, and the cup cover of the ultrafiltration cup is not shown.
[0053] Among them, 1-cup body, 11-cup body, 12-guiding part, 13-drainage area, 14-maximum volume indicator, 15-mounting seat, 151-fan-shaped seat, 152-assembly part, 2-outlet, 3-cup cover, 31-air pressure balance port, 32-liquid replenishment connector, 321-hose connecting part, 4-liquid replenishment port, 5-reflux port, 51-first reflux port, 52-second reflux port, 6-container, 71-first pipeline, 72-second pipeline, 73-third pipeline, 8-ultrafiltration membrane package. DETAILED DESCRIPTION
[0054] In order to enable those skilled in the art to better understand the solution of the utility model, the following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the utility model.
[0055] An ultrafiltration cup includes a cup body 1 with an open top, and a cup cover 3 detachably and sealedly arranged on the top of the cup body 1. The cup body 1 at least includes a cup body 11 in a hollow cylindrical shape, a flow guide 12 formed at the bottom of the cup body 11, and a drainage area 13 formed at one end of the flow guide 12 away from the cup body 11, and the side wall of the drainage area 13 is provided with an outlet 2 for discharging liquid in the cup body 1.
[0056] The cup body 11 and / or the cup cover 3 have a liquid replenishment port 4, which is located above the outlet 2. Generally speaking, during the filtering process, the liquid level in the cup body 1 should be kept at a certain height as much as possible. When part of the liquid is discharged to the outside through the outlet 2, it is necessary to replenish the cup body 1 with liquid from the outside. The function of the liquid replenishment port 4 is to connect the liquid container through a pipeline, so that the liquid in the liquid container is transported to the cup body 1 through the peristaltic pump and the liquid replenishment port 4, ensuring that the liquid level in the cup body 1 remains basically unchanged.
[0057] The side wall of the cup body 11 is provided with at least one reflux port 5, which is used to connect the outside and the inside of the cup body 11. Specifically, the function of the reflux port 5 is that the liquid discharged from the outlet 2 of the cup 1 enters the ultrafiltration membrane module 8, and the feed liquid before the membrane then circulates back to the cup 1 from the reflux port 5. The reflux liquid and the feed liquid in the cup 1 are then discharged to the ultrafiltration membrane module 8 through the outlet 2 together, so that the reflux liquid can be processed by the ultrafiltration membrane module 8 again. This reflux port 5 is closer to the diversion part 12 than the liquid supplement port 4. In other words, the reflux port 5 is located below the liquid supplement port 4.
[0058] Here, the position of the reflux port 5 on the cup body 11 is not specifically limited for now. The main limitation is that the reflux port 5 is arranged below the position of the liquid supplement port 4 on the side wall of the cup body 11, that is, the reflux port 5 can be arranged at a position more than half of the height of the side wall of the cup body 11. For example, Figure 1 as shown, the reflux port 5 can also be arranged at a position less than half of the height of the side wall of the cup body 11, such as Figure 2 shown.
[0059] Compared with the prior art in which the reflux port is arranged on the cup lid, setting the reflux port 5 on the side wall of the cup body 11 enables the reflux liquid to flow downward along the inner wall of the cup body 11 after entering the cup 1. The inner wall of the cup body 11 plays a role in guiding the flow. Compared with the liquid directly injected into the cup 1 from the cup lid 3, under the guiding action of the inner wall of the cup body 11, the liquid will not impact the liquid in the cup 1 to form liquid droplet splashing, and the flow impact of the liquid is alleviated, the liquid flow rate is smoother, preventing the occurrence of violent flow impact or collision of the liquid, thereby reducing the possibility of inactivation of the protein component in the feed liquid. At the same time, the small liquid impact force can also reduce the generation of bubbles.
[0060] Moreover, the reflux port 5 is arranged below the liquid supplement port 4. First of all, the solid content of the reflux liquid injected from the reflux port 5 is higher than that of the feed liquid conveyed through the liquid supplement port 4. It is easy to form further deposition when staying in the cup 1 for a long time, resulting in an increase in the solid content of the bottom material, increasing the inlet liquid pressure. When the downstream of the ultrafiltration cup is a dialysis operation, the deposition of the bottom material will also lead to a reduction in dialysis efficiency and even cause the feed liquid to be stratified. By setting the reflux port 5 closer to the diversion part 12, it is beneficial for the reflux liquid to be discharged through the outlet 2 faster, shortening the time for the reflux liquid to stay in the cup 1 and preventing the occurrence of deposition.
[0061] Secondly, generally speaking, the liquid level in the cup body 1 is slightly lower than the liquid replenishing port 4. The liquid return port 5 is arranged below the liquid replenishing port 4, so that after the returned liquid enters the cup body 1, it can directly mix with the liquid in the cup body 1, or flow into the liquid in the cup body at an acute angle to the horizontal plane within a short time and mix with the liquid in the cup body 1. The impact and collision of the liquid flow basically no longer occur, preventing liquid droplets from splashing and reducing the possibility of bubble generation, and better protecting the activity of the protein component.
[0062] Specifically, defining the height of the cup body main body 11 as H, the axial distance between the liquid return port 5 and the bottom of the cup body main body 11 is not greater than 1 / 2H. In other words, the liquid return port 5 is located at or below half of the height of the cup body main body 11, as Figure 2 shown, at this time the liquid return port 5 is located below half of the height of the cup body main body 11.
[0063] In the actual application scenario, the liquid level in the cup body 1 is generally above half of the height of the cup body main body 11. Therefore, by arranging the liquid return port 5 at or below half of the height of the cup body main body 11, after the returned liquid is injected into the cup body 1 through the liquid return port 5, it directly mixes with the liquid in the cup body 1, and even does not require the returned liquid to flow down along the inner wall of the cup body 1. The impact and collision of the liquid flow are directly absorbed by the liquid in the cup body 1, and no bubbles are generated, and the activity of the protein component is better protected.
[0064] More specifically, the liquid return port 5 is located at the bottom of the cup body main body 11 and is adjacent to the starting end of the guiding part 12. In this embodiment, the guiding part 12 is conical, and its inner diameter gradually decreases from the bottom of the cup body main body 11 to the liquid discharge area 13. In other words, the inner diameter of the guiding part 12 gradually decreases from top to bottom, and a liquid discharge area 13 is arranged downstream of the guiding part 12. A magnetic stirring rotor can be placed in the liquid discharge area 13 to stir the liquid in the liquid discharge area 13 to avoid sedimentation of the liquid, so that the liquid in the liquid discharge area 13 can be smoothly discharged through the outlet 2.
[0065] Such as Figure 4 、 Figure 6As shown, the reflux port 5 is arranged at the bottom of the cup body 11 and the starting end of the diversion part 12, that is, the lowest liquid level of the reflux port 5 is adjacent to the maximum inner diameter of the diversion part 12. Since the concentration of the reflux liquid flowing into the reflux port 5 is relatively higher, that is, the solid content of this liquid is higher, the reflux liquid staying in the cup body 1 for a long time is likely to form further deposition, resulting in an increase in the solid content of the bottom material, increasing the pressure of the incoming liquid. In addition, when the downstream of the ultrafiltration cup is a dialysis operation, the deposition of the material in the cup body 1 will lead to a reduction in dialysis efficiency and even cause the liquid material to stratify. Therefore, the reflux port 5 is located at the bottom of the cup body 11 and adjacent to the diversion part 12, so that the reflux liquid flowing into the reflux port 5 can be discharged again more quickly, avoiding the deposition of the bottom material, preventing the liquid material from stratifying, and reducing the incoming liquid pressure. At the same time, the reflux port 5 is located at the bottom of the cup body 11. Even if the volume of the liquid in the cup body 1 is very small, the reflux liquid can flow along the inner wall of the diversion part 12 and be mixed with the liquid in the cup body 1 in a short time, achieving the purpose of reducing the impact of fluid flow, avoiding liquid droplet splashing, and preventing the generation of bubbles, and better protecting the activity of the protein component.
[0066] Furthermore, in most cases, the liquid level height in the cup body 1 is above the diversion part 12. The reflux port 5 is arranged at the bottom of the cup body 11 and the starting end of the diversion part 12, that is, the lowest part of the reflux port 5 is flush with the starting end of the diversion part 12. Exactly speaking, the lowest part of the reflux port 5 is flush with the liquid level height in the cup body 1, or the lowest part of the reflux port 5 is below the liquid level height in the cup body 1, so that the liquid injected from the reflux port 5 can be directly mixed with the liquid in the cup body 1, there is no situation of liquid droplet splashing, the impact and collision of the liquid flow are absorbed by the liquid in the cup body 1, the activity of the protein component is better protected, and no foaming will occur.
[0067] The inclination angle of the side wall of the diversion part 12 is 7 - 12°, that is Figure 6The α angle in it is 7 - 12°. If the α angle is less than 7°, the inclination angle of the diversion part 12 is too small. When the liquid in the cup body 1 forms aggregates, the aggregates cannot quickly enter the liquid discharge area 13 through the diversion part 12 and may even stay in the diversion part 12. The diversion part 12 cannot play a good guiding role, which is not conducive to the smooth discharge of the liquid through the outlet 2. If the α angle is greater than 12°, the inclination angle of the diversion part 12 is too large, resulting in a relatively violent fluid flow impact when the liquid flows from the diversion part 12 to the liquid discharge area 13. As a result, the protein components in the liquid are inactivated, and a large number of bubbles are also easily generated. Moreover, the inner diameter of the liquid discharge area 13 is relatively large. When too much liquid accumulates in the liquid discharge area 13, the liquid in the liquid discharge area 13 cannot be fully stirred by the magnetic stirring rotor, and there is also a risk of local deposition, which has an adverse effect on the discharge of the liquid through the outlet 2. Furthermore, when the α angle is greater than 12°, the larger inner diameter of the liquid discharge area 13 leads to an increase in its volume. At this time, it is necessary to increase the magnetic stirring force to evenly disperse the liquid. Once the stirring force is too large, it is easy to cause the inactivation of the liquid protein, and the activity of the protein components cannot be protected.
[0068] In this embodiment, the volume of the liquid discharge area 13 is 1 - 3% of the maximum volume of the cup body 1. Since the protein components in the liquid are easily inactivated, if the volume of the liquid discharge area 13 is greater than 3% of the maximum volume of the cup body 1, the volume of the liquid discharge area 13 is too large, resulting in an increased possibility of inactivation of the protein components because too much liquid in the cup body 1 is in a stirred state. Moreover, when there is more liquid in the liquid discharge area 13, it is necessary to increase the magnetic stirring force to evenly disperse the liquid. Once the stirring force is too large, it is easy to cause the inactivation of the liquid protein, and the activity of the protein components cannot be protected. In addition, when the volume of the liquid discharge area 13 is not greater than 3% of the maximum volume of the cup body 1, the residue of the liquid can also be reduced.
[0069] If the volume of the liquid discharge area 13 is less than 1% of the maximum volume of the cup body 1, the volume of the liquid discharge area 13 is too small, and the residence time of the liquid in the liquid discharge area 13 is too short. It is possible that the liquid in the cup body 1 is discharged through the outlet without being stirred, which is not conducive to the effective treatment of the liquid by the ultrafiltration membrane package 8. In addition, too small a volume of the liquid discharge area 13 will cause inconvenience in its processing and manufacturing, especially it is difficult to form the outlet 2 on the side wall of the liquid discharge area 13. Furthermore, when the volume of the liquid discharge area 13 is too small, the magnetic stirring rotor installed in it may form a stirring with too large a stirring force, and at this time, the possibility of inactivation of the protein components is also easily increased. Within the above proportional range, the stirring force in the liquid discharge area 13 is relatively gentle, the possibility of inactivation of the protein components is reduced, and it can ensure that the liquid at the bottom of the cup body 1 does not deposit, avoid too short a residence time of the liquid in the liquid discharge area 13, ensure the effective treatment of the liquid, and facilitate the processing and manufacturing of the cup body 1.
[0070] The axial distance between the lowest point of the outlet 2 and the bottom wall of the liquid discharge area 13 is not greater than 1 mm, that is Figure 6where h ≤ 1 mm, at this time the processing difficulty of the outlet 2 is reduced, which is convenient for the manufacture of the cup body 1, and can maximally avoid the accumulation of the liquid material in the liquid discharge area 13, discharge the liquid material as much as possible, and reduce the residue of the liquid material in the liquid discharge area 13.
[0071] In the above solution, the number of the return ports 5 is one, but the number of the return ports 5 is not limited to only one. For example, Figure 3 as shown, it may include a first return port 51 at the bottom of the cup body 11 and a second return port 52 at half of the height of the cup body 11. At this time, the returned liquid is divided into two streams and respectively transported into the cup body 1 from the first return port 51 and the second return port 52. While achieving the effect that the return port 5 is located at the bottom of the cup body 1, the flow velocity of each of the two returned liquid streams is lower, the impact force of the flowing returned liquid is dispersed, and the flow impact and collision of the liquid basically no longer occur, so that the activity of the protein component is better protected. Of course, the number of the return ports 5 may also be three or more, and specific limitations are not made.
[0072] The central axis of the return port 5 and the central axis of the outlet 2 are located in the same axial plane. The above includes that the return port 5 and the outlet 2 are located on the same side of the axial plane, and also includes that the two are located on the opposite sides of the axial plane.
[0073] In this embodiment, the two are located on the same side of the axial plane, so that the flow distance of the returned liquid between the return port 5 and the outlet 2 is the shortest, the returned liquid can be quickly discharged outwards again, avoiding the deposition of the liquid material, preventing the stratification of the liquid material, and improving the dialysis efficiency.
[0074] When the return port 5 and the outlet 2 are located on the opposite sides of the axial plane, the liquid injected into the return port 5 does not need to turn and directly flows towards the outlet 2, which is beneficial to the quick discharge of the returned liquid again.
[0075] In the above structure, the liquid supplement port 4 may be provided on the cup body 11 or on the cup cover 3. In this embodiment, the liquid supplement port 4 is located on the side wall of the cup body 11, and the central axis of the liquid supplement port 4 is not lower than the maximum volume indicating part 14. Specifically, the side wall of the cup body 11 is provided with the maximum volume indicating part 14 of the cup body 1. For example, Figure 4 as shown, the maximum volume indicating part 14 of the cup body 1 is 1000 mL, which is located on the horizontal plane where L1 is located, the central axis of the liquid supplement port 4 is located on the horizontal plane where L2 is located, and L2 is above L1.
[0076] In most actual application scenarios, the liquid level in the cup body 1 is maintained at or near the height of the maximum volume indicating portion 14. The central axis of the liquid replenishing port 4 is higher than the maximum volume indicating portion 14, which can not only prevent the liquid in the cup body 1 from being sucked back into the front liquid container, but also enable the liquid input from the liquid replenishing port 4 to quickly mix with the liquid in the cup body 1. The flow impact and collision of the liquid basically no longer occur, preventing liquid droplets from splashing and reducing the possibility of bubble generation, and better protecting the activity of the protein component.
[0077] In another embodiment, the liquid replenishing port is located on the cup lid 3. As Figure 8 , Figure 9 shown, specifically, a liquid replenishing joint 32 is formed on the cup lid 3. The liquid replenishing joint 32 has a hose connecting portion 321 extending towards the inside of the cup body main body 11. At this time, a hose can be connected to the hose connecting portion 321, and the hose is inserted below the liquid level in the cup body 1. For working conditions with a relatively large liquid replenishing flow rate, using the liquid replenishing joint 32 on the above-mentioned cup lid 3, the replenished liquid directly mixes with the liquid in the cup body 1 through the liquid replenishing joint 32 and the hose, and the fluid impact is absorbed by the liquid, which can effectively prevent liquid droplets from splashing, reduce the possibility of protein component inactivation, and avoid bubble generation. Moreover, due to the large liquid replenishing flow rate, the risk of backflow of the liquid in the cup body 1 can be eliminated.
[0078] As Figures 7 - 9 shown, a pneumatic balance port 31 is also provided at the center of the cup lid 3, which communicates the inside of the cup body 1 with the outside air and is used to balance the internal and external air pressures of the cup body 1 to ensure that the liquid in the cup body 1 can be discharged smoothly.
[0079] One end of the liquid discharge area 13 away from the cup body main body 11 is provided with a mounting base 15. In other words, the cup lid 3, the cup body main body 11, the diversion portion 12, the liquid discharge area 13 and the mounting base 15 are arranged in sequence from top to bottom. As Figure 5 shown, the mounting base 15 includes a pair of sector-shaped seat bodies 151 with an outer diameter not less than the outer diameter of the cup body main body 11, and an assembly portion 152 extending radially outward from the outer wall of each sector-shaped seat body 151. The pair of sector-shaped seat bodies 151 are arranged radially opposite to each other and are circumferentially staggered with the outlet 2. Specifically, the pair of sector-shaped seat bodies 151 are symmetrically arranged with respect to the vertical plane of the cup body 1 passing through the outlet 2, so as not to affect the connection between the outlet 2 and the external pipeline, avoid interference between the external pipeline and the sector-shaped seat bodies 151, and also ensure the stability of the placement of the cup body 1.
[0080] As Figure 10As shown in the figure, an ultrafiltration system includes the above-mentioned ultrafiltration cup, a container 6, and an ultrafiltration membrane module 8. The container 6 is located upstream of the ultrafiltration cup and is connected to the liquid supplement port 4 of the ultrafiltration cup through a first pipeline 71 for storing the liquid to be processed. And a peristaltic pump is connected to the first pipeline 71. The ultrafiltration membrane module 8 is located downstream of the ultrafiltration cup and is connected to the outlet 2 of the ultrafiltration cup through a second pipeline 72. And a peristaltic pump is connected to the second pipeline 72. The ultrafiltration membrane module 8 is connected to the reflux port 5 of the ultrafiltration cup through a third pipeline 73 for processing the liquid output from the ultrafiltration cup, specifically for concentrating or dialyzing the liquid. And the liquid in front of the membrane of the ultrafiltration membrane module 8 returns to the ultrafiltration cup through the third pipeline 73.
[0081] The use process of the ultrafiltration system is that the liquid is transported from the container 6 to the ultrafiltration cup. Specifically, the end of the first pipeline 71 is connected to the liquid supplement port 4 of the ultrafiltration cup. The liquid volume in the cup body 1 is observed by using the indicating part. Generally speaking, the liquid level of the liquid in the cup body 1 remains at the maximum volume indicating part 14. The liquid after passing through the cup body 1 is output from the outlet 2 and is transported to the ultrafiltration membrane module 8 through the second pipeline 72. The liquid in front of the membrane returns to the reflux port 5 through the third pipeline 73, and then circulates back to the cup body 1 from the reflux port 5. The reflux liquid is mixed with the liquid in the cup body 1 and then is discharged to the ultrafiltration membrane module 8 through the outlet 2 and the second pipeline 72 together, so that the reflux liquid can be processed by the ultrafiltration membrane module 8 again to meet the processing requirements of the liquid.
[0082] Among them, the ultrafiltration membrane module 8 is generally used for concentrating or dialyzing the liquid. For example, if the liquid is only processed by the ultrafiltration membrane module once, the concentration requirement may not be met. Therefore, the liquid in front of the membrane needs to return to the ultrafiltration cup and be concentrated by the ultrafiltration membrane module again, and even more times of reflux may be required.
[0083] The above specific embodiments are used to explain and illustrate the present invention, rather than to limit the present invention. Any modification and change made within the spirit and scope of the claims of the present invention fall within the protection scope of the present invention.
Claims
1. An ultrafiltration cup, characterized in that, Comprising: A cup body, at least including a cup body main body, a diversion part formed at the bottom of the cup body main body, and a liquid discharge area formed at one end of the diversion part away from the cup body main body, wherein an outlet is provided on the side wall of the liquid discharge area; A cup lid, detachably and sealingly arranged on the top of the cup body; The cup body main body or the cup lid has a liquid supplement port located above the outlet; At least one reflux port is provided on the side wall of the cup body main body, which is used to connect the outside and the inside of the cup body main body, and the reflux port is closer to the diversion part than the liquid supplement port.
2. The ultrafiltration cup according to claim 1, wherein: The height of the cup body main body is H, and the axial distance between the reflux port and the bottom of the cup body main body is not greater than 1 / 2H.
3. The ultrafiltration cup according to claim 1 or 2, characterized in that: The reflux port is located at the bottom of the cup body main body and is adjacent to the starting end of the diversion part.
4. The ultrafiltration cup according to claim 1 or 2, characterized in that: The reflux port includes a first reflux port located at the bottom of the cup body main body and a second reflux port located at half of the height of the cup body main body.
5. The ultrafiltration cup according to claim 1 or 2, characterized in that: The central axis of the reflux port and the central axis of the outlet are located in the same axial plane.
6. The ultrafiltration cup according to claim 1, wherein: A maximum volume indicating part of the cup is provided on the side wall of the cup body main body, and the liquid supplement port is located on the side wall of the cup body main body, and its central axis is not lower than the maximum volume indicating part.
7. The ultrafiltration cup according to claim 1, characterized in that: The diversion part is conical, and its inner diameter gradually decreases from the bottom end of the cup body main body to the liquid discharge area, and the inclination angle of its side wall is 7-12°.
8. The ultrafiltration cup according to claim 1 or 7, characterized in that: The volume of the liquid discharge area is 1-3% of the maximum volume of the cup; and / or, the axial distance between the lowest part of the outlet and the bottom wall of the liquid discharge area is not greater than 1 mm.
9. The ultrafiltration cup according to claim 1, characterized in that: The cup lid is also provided with a pressure balance port for balancing the air pressure inside and outside the cup; and / or, the cup lid is provided with a liquid supplement joint, and the liquid supplement joint has a hose connection part extending towards the inside of the cup body main body.
10. The ultrafiltration cup according to claim 1, wherein: An installation base is provided at one end of the liquid discharge area away from the cup body main body, which includes a pair of sector-shaped seat bodies with an outer diameter not less than the outer diameter of the cup body main body, and an assembly part extending radially outwards along the outer wall of each sector-shaped seat body. The pair of sector-shaped seat bodies are arranged radially opposite to each other and are circumferentially offset from the outlet.
11. An ultrafiltration system, characterized in that, Comprising: The ultrafiltration cup according to any one of claims 1-10; A container, connected to the liquid supplement port of the ultrafiltration cup through a first pipeline, for storing the liquid to be processed; An ultrafiltration membrane package, connected to the outlet and the reflux port of the ultrafiltration cup through a second pipeline and a third pipeline respectively, for processing the liquid output from the ultrafiltration cup, and the liquid before the membrane of the ultrafiltration membrane package returns to the ultrafiltration cup through the third pipeline.