Liquid processing apparatus and detection analysis system

Abstract

The utility model discloses a liquid treatment device and a detection analysis system, the liquid treatment device comprises a pipetting assembly, a sample collecting assembly, a moving assembly, a connecting assembly and at least one liquid pump, the pipetting assembly is connected with the moving assembly, the connecting assembly is respectively connected with the pipetting assembly and the moving assembly, and the liquid pump is connected with the sample collecting assembly. The pipetting assembly moves to the position where the sample collecting assembly is located through the moving assembly, and the pipetting assembly is connected with at least one liquid pump; the pipetting assembly comprises at least one pipeline, the at least one pipeline is located in the connecting assembly, and the pipetting assembly and the at least one liquid pump are connected through the at least one pipeline penetrating through the interior of the connecting assembly. According to the embodiment of the utility model, batch pipetting processing can be realized through automatic interaction, and the pipetting stability and efficiency are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of automated liquid handling, and particularly relates to a liquid handling device and a detection and analysis system. Background Art

[0002] In the research and detection of laboratories in the fields of biology, chemistry, pharmacy, medicine, etc., a large number of accurate pipetting operations are often required, that is, various different samples and liquid reagents are transferred to the equipment for analysis or testing in accurate volumes. The traditional pipetting method is to use a pipette (such as a dropper, a Pasteur pipette, a micropipette, etc.) to suck the liquid (source liquid) to be transferred from the source container, and then release the liquid into the target container. The traditional pipetting method requires manual operation and can only handle the situation with fewer transfer times. For multiple liquid transfers, it is prone to large human errors, affecting accuracy, and has low efficiency. At the same time, the experimental process may have an adverse impact on human health. Summary of the Utility Model

[0003] In view of the above problems of the prior art, the utility model discloses a liquid handling device and a detection and analysis system, which can realize batch pipetting processing through automated interaction, and improve the pipetting stability and efficiency. The technical scheme disclosed by the utility model is as follows:

[0004] According to one aspect of the embodiments disclosed by the utility model, a liquid handling device is provided, which includes a pipetting component, a sample collection component, a moving component, a connecting component, and at least one liquid pump. The pipetting component is connected to the moving component, the connecting component is respectively connected to the pipetting component and the moving component, the pipetting component is moved to the position where the sample collection component is located through the moving component, and the pipetting component is connected to the at least one liquid pump;

[0005] The pipetting component includes at least one pipeline, the at least one pipeline is located inside the connecting component, and the pipetting component is connected to the at least one liquid pump through the at least one pipeline passing through the inside of the connecting component.

[0006] Optionally, the liquid handling device further includes a first fixing component, and both the moving component and the connecting component are arranged on the first fixing component;

[0007] The moving component includes a moving member and a driving component, the driving component is arranged on the first fixing component, and the moving member is slidably connected to the driving component.

[0008] Optionally, the connecting component includes a first connecting piece and a second connecting piece, the first fixing component includes a first fixing bracket and a second fixing bracket, and the pipetting component further includes a bearing structure;

[0009] One end of the first connecting member is connected to the first fixing bracket, the other ends of the first connecting member and the second connecting member are both connected to the second fixing bracket, and one end of the second connecting member is connected to the bearing structure.

[0010] Optionally, the pipetting assembly includes at least one pipette tube, each pipette tube is arranged on the bearing structure, each pipette tube corresponds to a pipeline, each pipette tube is connected to the at least one liquid pump through the corresponding pipeline, and between each pipette tube and the at least one liquid pump, it is connected through the corresponding pipeline passing through the inside of the first connecting member and the second connecting member.

[0011] Optionally, the moving member includes a first moving member and a second moving member, the driving assembly includes a first driving member and a second driving member, the first fixing assembly includes a first fixing bracket and a second fixing bracket, and the pipetting assembly further includes a bearing structure;

[0012] The first driving member is connected to the first fixing bracket, the second driving member is connected to the second fixing bracket, the second fixing bracket is connected to the first moving member, and the second moving member is connected to the bearing structure;

[0013] The first driving member is slidably connected to the first moving member, and the second driving member is slidably connected to the second moving member.

[0014] Optionally, an induction member is arranged on the moving member, and at least two induction limiting structures are arranged on the driving assembly, and the at least two induction limiting structures include a first induction limiting structure and a second induction limiting structure;

[0015] When the induction member is located at the first induction limiting structure, the moving member is located at the lower limit moving position, and the pipetting assembly is located above the waste liquid collection assembly; when the induction member is located at the second induction limiting structure, the moving member is located at the upper limit moving position.

[0016] Optionally, the liquid processing device further includes a second fixing assembly, the second fixing assembly includes at least one fixing structure, each pipeline corresponds to a fixing structure, and each pipeline passes through the corresponding fixing structure.

[0017] Optionally, the liquid processing device further includes a waste liquid collection assembly and a base, the sample collection assembly and the waste liquid collection assembly are both arranged on the base, and the pipetting assembly is respectively moved to the positions where the sample collection assembly and the waste liquid collection assembly are located through the moving assembly;

[0018] The waste liquid collection component includes a waste liquid collection main body and a waste liquid collection channel. An opening corresponding to the waste liquid collection channel is provided on the base. The waste liquid collection channel passes through the opening, and the waste liquid collection main body is connected to the waste liquid collection channel.

[0019] Optionally, the liquid processing device further includes a measuring mechanism, a base, and a housing. The measuring mechanism and the housing are both fixedly arranged on the base.

[0020] The sample collection component includes a collection container and a receiving groove. The collection container is placed in the receiving groove. The collection container passes through the housing and is placed in the receiving groove. The receiving groove is fixedly connected to the measuring mechanism, and both the receiving groove and the measuring mechanism are located inside the housing.

[0021] According to another aspect of the disclosed embodiments of the present invention, a detection and analysis system is provided, including the liquid processing device described in any one of the above.

[0022] The technical solutions provided by the disclosed embodiments of the present invention at least bring the following beneficial effects:

[0023] The liquid processing device provided by the present invention includes a liquid transfer component, a sample collection component, a moving component, a connecting component, and at least one liquid pump. The liquid transfer component is connected to the moving component, and the connecting component is respectively connected to the liquid transfer component and the moving component. The liquid transfer component is moved to the position where the sample collection component is located through the moving component, and the liquid transfer component is connected to at least one liquid pump; the liquid transfer component includes at least one pipeline, and at least one pipeline is located inside the connecting component. The liquid transfer component and at least one liquid pump are connected through at least one pipeline passing through the inside of the connecting component, so as to realize batch processing of liquid transfer through automated interaction, improve the liquid transfer efficiency; and realize automated control of the liquid transfer operation in a pumping manner through the liquid pump, accurately control the liquid transfer volume, improve the stability and accuracy, and effectively avoid the health threat to experimental personnel at the same time.

[0024] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the present disclosure. Description of the Drawings

[0025] The drawings here are incorporated into the specification and constitute a part of this specification, showing the embodiments that conform to the disclosure of the present application, and are used together with the specification to explain the principles of the present disclosure, and do not constitute an improper limitation to the disclosure of the present application.

[0026] Figure 1 It is a schematic diagram of a liquid processing device provided by an embodiment of the present application from the perspective of the sample collection component side;

[0027] Figure 2It is a schematic diagram of a liquid handling device provided by an embodiment of the present application from the perspective of the first connection member;

[0028] Figure 3 It is a schematic diagram of a liquid handling device provided by an embodiment of the present application from the perspective of the second connection member;

[0029] Figure 4 It is a schematic diagram of the structure of a moving component provided by an embodiment of the present application;

[0030] Figure 5 It is a schematic diagram of a sensing member and a sensing limit structure provided by an embodiment of the present application;

[0031] Figure 6 It is a schematic diagram of the structure of a waste liquid collection component provided by an embodiment of the present application;

[0032] Figure 7 It is a schematic diagram of the structure of a sample collection component provided by an embodiment of the present application;

[0033] Among them, the corresponding reference numerals in the figure are: 1 - pipetting assembly; 11 - pipette; 111 - pipette body; 112 - pipette tip; 12 - carrying structure; 2 - sample collection component; 21 - collection container; 22 - receiving groove; 3 - moving component; 31 - moving member; 311 - first moving member; 312 - second moving member; 313 - first sensing member; 314 - second sensing member; 315 - first sensing limit structure; 316 - second sensing limit structure; 32 - driving component; 321 - first driving member; 322 - second driving member; 33 - first fixing component; 331 - first fixing bracket; 332 - second fixing bracket; 4 - connection component; 41 - first connection member; 42 - second connection member; 5 - second fixing component; 6 - waste liquid collection component; 61 - waste liquid collection main body; 62 - waste liquid collection channel; 7 - measuring mechanism; 8 - leveling component; 81 - leveling structure; 9 - base; 10 - housing; A - one end of the first connection member; B - the other end of the first connection member; C - the other end of the second connection member; D - one end of the second connection member. Detailed implementation manners

[0034] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present application without creative efforts shall fall within the protection scope of the present application.

[0035] It should be noted that the "one embodiment" or "embodiment" referred to in the specification of the embodiments of the present application means specific features, structures or characteristics that can be included in at least one implementation manner of the present application. It should be understood that in the specification, claims and the above-mentioned drawings of the embodiments of the present application, the orientation or positional relationship indicated by terms such as "upper", "lower", "top", "bottom", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, so it cannot be understood as a limitation to the present application. The terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of such features. Moreover, the terms "first", "second", etc. are used to distinguish similar objects and do not necessarily have to be used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged under appropriate circumstances so that the embodiments of the present application described here can be implemented in an order other than those illustrated or described here. In addition, in the description of this embodiment, unless otherwise specified, the meaning of "a plurality" is two or more. In addition, the terms "comprising" and "having" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system or product that includes a series of steps or units does not necessarily have to be limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or are inherent to these processes, methods, products or devices.

[0036] In order to make the purpose, technical solutions and advantages of the disclosure of the embodiments of the present application clearer and more understandable, the following further details the embodiments of the present application in conjunction with the drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the embodiments of the present application and are not used to limit the embodiments of the present application.

[0037] In scenarios where pipetting of test tube specimens is required in biological laboratories, medical laboratories, chemical laboratories, and other laboratories, when conducting biochemical analysis tests or experiments, laboratory personnel generally complete the aspiration and dispensing of samples or reagents by manually operating pipettes. However, a sterile environment is required during the inspection process in the laboratory, and frequent manual operations are likely to cause contamination; laboratory personnel need to replace pipettes that support different volume ranges to separately perform pipetting operations on small-volume and large-volume liquids, and the pipetting workload is extremely large, resulting in low work efficiency; at the same time, when performing pipetting operations on different solutions, it is usually necessary to frequently clean or replace pipette tips, increasing the consumable cost and easily causing secondary cross-contamination. To solve the above problems, the present utility model proposes a liquid handling device that can automatically control pipetting operations, meet high-throughput requirements, achieve batch pipetting processing, improve pipetting stability and efficiency, effectively avoid cross-contamination at the same time, and reduce the consumable cost.

[0038] The following will combine the attached Figures 1-7 to introduce the technical solutions in the embodiments of this application.

[0039] Please refer to Figures 1-7 A liquid handling device provided in an embodiment of this application includes a pipetting assembly 1, a sample collection assembly 2, a moving assembly 3, a connection assembly 4, and at least one liquid pump (not shown). The pipetting assembly 1 is connected to the moving assembly 3, the connection assembly 4 is respectively connected to the pipetting assembly 1 and the moving assembly 3, the pipetting assembly 1 is moved to the position where the sample collection assembly 2 is located through the moving assembly 3, and the pipetting assembly 1 is connected to at least one liquid pump; the pipetting assembly 1 includes at least one pipeline (not shown), at least one pipeline is located inside the connection assembly 4, and the pipetting assembly 1 is connected to at least one liquid pump through at least one pipeline passing through the inside of the connection assembly 4.

[0040] Specifically, the connection assembly 4 contains a hollow structure inside, and the above pipeline can pass through the inside of the connection assembly 4. The moving assembly 3 can drive the pipetting assembly 1 to move in the horizontal direction (X-axis and Y-axis directions) so that the pipetting assembly 1 moves to the position where the sample collection assembly 2 is located.

[0041] Optionally, the pipetting assembly 1 includes at least one pipette 11. Each pipette 11 corresponds to one pipeline, and each pipette 11 is connected to at least one liquid pump through the corresponding pipeline. Each pipette 11 is connected to at least one liquid pump through the corresponding pipeline passing through the inside of the moving assembly 4. Specifically, the pipeline can be set according to actual application requirements, for example, it can be a soft rubber tube.

[0042] Specifically, the pipette 11 includes a pipette main body 111 and a pipette tip 112. The pipette main body 111 and the pipette tip 112 are detachably connected, and the pipette tip 112 can be a capillary tube or a tubular structure with a nozzle.

[0043] Optionally, the above liquid handling device further includes a liquid storage assembly (not shown), which is connected to at least one liquid pump and is used to store the sample liquid and cleaning liquid provided to the pipette 11. Specifically, the liquid storage assembly may include at least one liquid storage tank, and the liquids in any two liquid storage tanks may be the same or different, and any one pipette 11 may be used to aspirate the same or different liquids.

[0044] In an optional embodiment, the liquid handling device further includes a first fixing assembly 33, and the moving assembly 3 and the connecting assembly 4 are both arranged on the first fixing assembly 33; the moving assembly 3 includes a moving member 31 and a driving assembly 32, the driving assembly 32 is arranged on the first fixing assembly 33, and the moving member 31 is slidably connected to the driving assembly 32.

[0045] Optionally, as Figures 1-3 shown, the above connecting assembly 4 includes a first connecting member 41 and a second connecting member 42, the first fixing assembly 33 includes a first fixing bracket 331 and a second fixing bracket 332, and the pipetting assembly 1 further includes a carrying structure 12; one end A of the first connecting member 41 is connected to the first fixing bracket 331, the other end B of the first connecting member 41 and the other end C of the second connecting member 42 are both connected to the second fixing bracket 332, and one end D of the second connecting member 42 is connected to the carrying structure 12.

[0046] In a specific embodiment, one end A of the first connecting member 41 is fixedly arranged on the first fixing bracket 331, one end C of the second connecting member 42 is fixedly arranged on the second fixing bracket 332, one end B of the first connecting member 41 moves with the first moving member 311, and one end D of the second connecting member 42 moves with the second moving member 312. Specifically, the first connecting member 41 and the second connecting member 42 may be drag chains, and the specific structures of the first connecting member 41 and the second connecting member 42 may be set according to actual application requirements, for example, they may be set as C-shaped structures.

[0047] Specifically, each pipette 11 is arranged on the carrying structure 12, the carrying structure 12 is provided with openings corresponding to each pipette 11, and each pipette 11 is fixedly arranged in the corresponding opening. Each pipette 11 is connected to at least one liquid pump through corresponding pipelines passing through the interiors of the first connecting member 41 and the second connecting member 42.

[0048] Optionally, as Figure 4As shown in the figure, the moving member 31 includes a first moving member 311 and a second moving member 312, the driving assembly 32 includes a first driving member 321 and a second driving member 322, and the first fixing assembly 33 includes a first fixing bracket 331 and a second fixing bracket 332; the first driving member 321 is connected to the first fixing bracket 331, the second driving member 322 is connected to the second fixing bracket 332, the second fixing bracket 331 is connected to the first moving member 311, and the second moving member 312 is connected to the bearing structure 12; the first driving member 321 is slidably connected to the first moving member 311, and the second driving member 322 is slidably connected to the second moving member 312. The above liquid handling device further includes a base 9, and the sample collection assembly 2 and the first fixing bracket 331 are arranged on the base 9.

[0049] In a specific embodiment, the first driving member 321 includes a first driving motor and a first output structure, the second driving member 322 includes a second driving motor and a second output structure, the first output structure is fixedly arranged on the first fixing bracket 331, the second output structure is fixedly arranged on the second fixing bracket 332, the first moving member 311 is slidably connected to the first output structure, the second moving member 312 is slidably connected to the second output structure, a chute corresponding to the first moving member 311 is arranged on the first output structure, and a chute corresponding to the second moving member 312 is arranged on the second output structure. Specifically, the first output structure and the second output structure are square column structures, and the first output structure and the second output structure are vertically arranged.

[0050] Specifically, the first driving motor drives the first output structure, drives the first moving member 311 to horizontally move along the corresponding chute, thereby driving the second fixing bracket 332 fixedly connected to the first moving member 311, and the second connecting member 42, the second driving member 322, the second moving member 312 and the pipetting assembly 1 connected to the second fixing bracket 332 to move together. At the same time, one end B of the first connecting member 41 is connected to the second fixing bracket 332, one end A of the first connecting member 41 is fixedly immovable on the first fixing bracket 331, and one end B of the first connecting member 41 moves synchronously with the second fixing bracket 332; based on a similar setting, the second driving motor drives the second moving member 312 to horizontally move along the corresponding chute in the direction of the second output structure, drives the pipetting assembly 1 to move synchronously. At the same time, one end D of the second connecting member 42 is connected to the pipetting assembly 1, and during the movement of the pipetting assembly 1, one end D of the second connecting member 42 moves synchronously with the pipetting assembly 1, and one end C of the second connecting member 42 is fixedly arranged on the second fixing bracket 332 without moving.

[0051] Optionally, the moving assembly 3 can be provided with a driving structure in the vertical direction (Z-axis direction) and a corresponding moving member according to actual application requirements, so that the pipetting assembly moves in the vertical direction.

[0052] Optionally, asFigure 5 As shown, the liquid handling device further includes a waste liquid collection assembly 6. An induction member is provided on the moving member 31, and at least two induction limit structures are provided on the driving assembly 32. The at least two induction limit structures include a first induction limit structure 315 and a second induction limit structure 316. When the induction member is at the first induction limit structure 315, the moving member 31 is at the lower limit moving position, and the liquid transfer assembly 1 is above the waste liquid collection assembly 2. When the induction member is at the second induction limit structure 316, the moving member 31 is at the upper limit moving position.

[0053] In a specific embodiment, a first induction member 313 is provided on the first moving member 311, a second induction member 314 is provided on the second moving member 312, and at least two induction limit structures are respectively provided on the first driving member 321 and the second driving member 322. The at least two induction limit structures include a first induction limit structure 315 and a second induction limit structure 316. The first induction limit structure 315 is provided at one end close to the connection between the first driving member 321 and the second driving member 322, and the second induction limit structure 316 is provided at one end far from the connection between the first driving member 321 and the second driving member 322. When the first induction member 313 and the second induction member 314 are at the corresponding first induction limit structure 315, the first moving member 311 is at the first lower limit moving position, the second moving member 312 is at the second lower limit moving position, and the liquid transfer assembly 1 is above the waste liquid collection assembly 2, that is, the preset initial position. When the first induction member 313 and the second induction member 314 are at the corresponding second induction limit structure 316, the first moving member 311 is at the first upper limit moving position, and the second moving member 312 is at the second upper limit moving position. The waste liquid collection assembly 6 is provided on the base 9.

[0054] In the embodiments of this specification, by the cooperation of the induction member and the induction limit structure, it can be recognized whether the induction member is at the induction limit structure, and the upper and lower limit positions where the first moving member 311 and the second moving member 312 can move are controlled. When two induction limit structures are respectively provided on the first driving member 321 and the second driving member 322, the two induction limit structures are respectively located at both ends of the first driving member 321 and the second driving member 322. When the induction members on the first moving member 311 and the second moving member 312 are both at the corresponding first induction limit structure 315 (that is, at the induction limit structure close to the connection end of the first driving member 321 and the second driving member 322), the liquid transfer assembly 1 can be above the waste liquid collection assembly 6, and the second induction limit structure 316 can be used to limit the maximum position where the first moving member 311 and the second moving member 312 can move.

[0055] Optionally, as Figure 6As shown, the pipetting assembly 1 is moved to the positions where the sample collection assembly 2 and the waste liquid collection assembly 6 are located respectively through the moving assembly 3; the waste liquid collection assembly 6 includes a waste liquid collection main body 61 and a waste liquid collection channel 62. An opening corresponding to the waste liquid collection channel 62 is provided on the base 9, and the waste liquid collection channel 62 passes through the opening, and the waste liquid collection main body 61 and the waste liquid collection channel 62 are connected.

[0056] Specifically, the specific structure of the waste liquid collection main body 61 can be set according to actual application requirements. For example, the waste liquid collection main body 61 can have a funnel-shaped structure, and a control valve can also be provided at one end of the waste liquid collection channel 62 located below the base 9. The waste liquid collection assembly 6 can be used to collect the residual liquid in the pipette 11 after the pipette 11 discharges the liquid, so as to avoid dripping on other positions such as the base 9 and causing pollution; the waste liquid collection assembly 6 can also be used to collect the cleaning liquid in the pipette 11 after cleaning the pipette 11. Correspondingly, at least one liquid storage tank is loaded with cleaning liquid. During the cleaning process of the pipetting assembly 1, under the action of the liquid pump, the cleaning liquid in the liquid storage tank enters the pipette 11 through the pipeline, is moved to the upper part of the position where the waste liquid collection assembly 6 is located through the moving assembly 3, discharges the cleaning liquid in the pipette 11, and is recycled along with the waste liquid collection assembly 6.

[0057] In the embodiment of the present specification, through the above settings, automatic cleaning of the liquid pump, pipeline and pipette 11 can be realized, and then the next pipetting process can be carried out, avoiding cross-contamination and reducing the cost of consumable replacement at the same time. The cleaning process can be repeated multiple times to improve the cleaning effect.

[0058] Optionally, the above liquid processing device further includes a second fixing assembly 5. The second fixing assembly 5 includes at least one fixing structure, and each pipeline corresponds to a fixing structure, and each pipeline passes through the corresponding fixing structure.

[0059] Specifically, each of the above pipelines is connected from the corresponding liquid pump to a corresponding fixing structure, and then enters the interior of the first connecting member 41 from one end A of the first connecting member 41, exits from one end B of the first connecting member 41, then enters the interior of the second connecting member 42 from one end C of the second connecting member 42, exits from one end D of the second connecting member 42, and then is connected to the corresponding pipette 11. Through the first connecting member 41 and the second connecting member 42, the routing area of the pipeline can be effectively fixed, avoiding occupying too much space in the vertical direction, and at the same time, the pipeline can be protected and the mutual winding and influence between multiple pipelines can be avoided.

[0060] Specifically, each fixing structure passes through the base 9. Openings corresponding to each fixing rod structure can be provided on the base 9, and each fixing structure is fixedly arranged in the openings; alternatively, multiple fixing structures can be installed on a mounting plate with corresponding openings, and an opening corresponding to the mounting plate is provided on the base 9, and the mounting plate with the fixing structures installed is arranged at the opening.

[0061] Optionally, as Figure 7 shown, the above liquid processing device further includes a measuring mechanism 7 and a housing 10. The measuring mechanism 7 and the housing 10 are both fixedly arranged on the base 9; the sample collection assembly 2 includes a collection container 21 and a receiving groove 22. The collection container 21 is placed in the receiving groove 22. The collection container 21 passes through the housing 10 and is placed in the receiving groove 22. The receiving groove 22 is fixedly connected to the measuring mechanism 7, and both the receiving groove 22 and the measuring mechanism 7 are located inside the housing 10.

[0062] Specifically, the measuring mechanism 7 can be a precision electronic scale to automatically weigh the liquid collected in the collection container 21 to ensure the accuracy of pipetting; at the same time, an outer cover (i.e., the above-mentioned housing 10) is configured for the precision electronic scale to reduce the influence of external environmental changes on the precision electronic scale and ensure the stability of pipetting data measurement.

[0063] Specifically, an opening corresponding to the collection container 21 is provided at the top of the housing 10. A protection structure can be provided at the opening, and the collection container 21 is arranged in the protection structure. The side of the protection structure in contact with the collection container 21 can be correspondingly set according to the size of collection containers 21 of different specifications. The collection container 21 can be configured with one or more specifications. For example, the specification of the collection container 21 can be configured as 8 ml, 40 ml, etc. to meet the experimental requirements of multi-specification reactions. The size of the receiving groove 22 can be correspondingly set according to the specification of the collection container 21.

[0064] Optionally, the above liquid processing device further includes a leveling component 8. The leveling component 8 is fixedly arranged on the base 9; the leveling component 8 includes at least one leveling structure 81, and at least one leveling structure 81 is evenly distributed at the edge of the base 9. Specifically, by setting the leveling structure 81, the base is adjusted to a horizontal state to achieve the horizontal placement of the liquid processing device and reduce the influence of measurement errors caused by inclination.

[0065] Optionally, the above liquid processing device further includes a control mechanism (not shown). The control mechanism is electrically connected to the pipetting component 1, the sample collection component 2, the moving component 3, and at least one liquid pump respectively. Optionally, the control mechanism is electrically connected to the measuring mechanism 7.

[0066] Specifically, the control mechanism is the control center of the liquid processing device, which is used to send working instructions to corresponding components in a timely manner respectively to achieve the coordinated control work among the components. For example, the control mechanism can adopt one or more of PLC programmable controllers, micro-control computers, computer control software, etc. Exemplarily, the control mechanism can be a PLC programmable controller, or other control mechanisms that can implement the above-mentioned logic control, which is not specifically limited herein. It should be noted that the above control logic can be realized by using the basic functions of existing control mechanisms.

[0067] The following describes the pipetting and cleaning processes based on the above liquid processing device, including:

[0068] The liquid processing device is leveled through a plurality of leveling structures 81 to ensure that the device is in a horizontal state during daily operation.

[0069] When performing a pipetting operation, under the driving action of the first driving member 321 and the second driving member 322, the pipette 11 is moved from the initial origin position to above the corresponding collection container 21 through the first moving member 311 and the second moving member 312. Then, based on the power provided by the liquid pump, the required liquid is pumped from the liquid storage tank into the corresponding pipette 11 through a pipeline, and the liquid in the pipette 11 is released into the corresponding specification collection container 21. The precision electronic scale weighs in real time, and when the weight reaches the preset threshold, the pipetting operation stops.

[0070] When performing a cleaning operation, under the driving action of the first driving member 321 and the second driving member 322, the pipette 11 is moved to above the corresponding waste liquid collection assembly 6 through the first moving member 311 and the second moving member 312. Then, based on the power provided by the liquid pump, the cleaning liquid is pumped from the liquid storage tank into the corresponding pipette 11 through a pipeline, and the cleaning liquid in the pipette 11 is discharged into the waste liquid collection main body 61 and recycled along the waste liquid collection channel 62. One cleaning is completed, and the cleaning process can be repeated multiple times.

[0071] The embodiment of the present application further provides a detection and analysis system, including the above liquid processing device.

[0072] Specifically, the above liquid processing device can be used in related detection and analysis systems in the fields of chemistry, biology, and medicine, etc.

[0073] As can be seen from the technical solutions provided in the embodiments of this specification above, the liquid handling device in this specification includes a pipetting assembly, a sample collection assembly, a moving assembly, a connecting assembly, and at least one liquid pump. The pipetting assembly is connected to the moving assembly, and the connecting assembly is respectively connected to the pipetting assembly and the moving assembly. The pipetting assembly is moved to the position where the sample collection assembly is located through the moving assembly, and the pipetting assembly is connected to at least one liquid pump; the pipetting assembly includes at least one pipeline, and at least one pipeline is located inside the connecting assembly. The pipetting assembly and at least one liquid pump are connected through at least one pipeline passing through the inside of the connecting assembly, so as to realize batch pipetting processing through automated interaction, improve the pipetting efficiency; and realize automated control of the pipetting operation in a pumping-in manner through the liquid pump, accurately control the pipetting volume, improve the stability and accuracy, and effectively avoid the health threat to the experimental personnel.

[0074] The embodiments in this specification are all described in a progressive manner. The same or similar parts among the embodiments can be referred to each other, and the key points of each embodiment are the differences from other embodiments. In particular, for the device embodiments, since they are basically similar to the method embodiments, the description is relatively simple, and the relevant parts can be referred to the description of the method embodiments.

[0075] After considering the specification and practicing the utility model disclosed herein, those skilled in the art will readily think of other embodiments of the utility model. The utility model aims to cover any variations, uses, or adaptations of the utility model disclosed, which follow the general principles of the utility model disclosed and include the common general knowledge or conventional technical means in the technical field not disclosed in the utility model. The specification and embodiments are only regarded as exemplary, and the true scope and spirit of the utility model are pointed out by the following claims.

[0076] It should be understood that the disclosure of the utility model is not limited to the precise structures already described and shown in the drawings, and various modifications and changes can be made without departing from its scope. The scope of the disclosure of the utility model is only limited by the appended claims.

Claims

1. A liquid handling device, characterized in that, Comprising a pipetting assembly (1), a sample collection assembly (2), a moving assembly (3), a connecting assembly (4) and at least one liquid pump, the pipetting assembly (1) is connected to the moving assembly (3), the connecting assembly (4) is respectively connected to the pipetting assembly (1) and the moving assembly (3), the pipetting assembly (1) is moved to the position where the sample collection assembly (2) is located through the moving assembly (3), and the pipetting assembly (1) is connected to the at least one liquid pump; The pipetting assembly (1) includes at least one pipeline, the at least one pipeline is located inside the connecting assembly (4), and the pipetting assembly (1) is connected to the at least one liquid pump through the at least one pipeline passing through the inside of the connecting assembly (4).

2. The liquid processing apparatus according to claim 1, characterized in that, The liquid processing device further includes a first fixing assembly (33), and both the moving assembly (3) and the connecting assembly (4) are arranged on the first fixing assembly (33); The moving assembly (3) includes a moving member (31) and a driving assembly (32), the driving assembly (32) is arranged on the first fixing assembly (33), and the moving member (31) is slidably connected to the driving assembly (32).

3. The liquid processing apparatus according to claim 2, wherein The connecting assembly (4) includes a first connecting member (41) and a second connecting member (42), the first fixing assembly (33) includes a first fixing bracket (331) and a second fixing bracket (332), and the pipetting assembly (1) further includes a carrying structure (12); One end (A) of the first connecting member (41) is connected to the first fixing bracket (331), the other end (B) of the first connecting member (41) and the other end (C) of the second connecting member (42) are both connected to the second fixing bracket (332), and one end (D) of the second connecting member (42) is connected to the carrying structure (12).

4. The liquid processing apparatus according to claim 3, characterized in that The pipetting assembly (1) includes at least one pipette (11), each pipette (11) is arranged on the carrying structure (12), each pipette (11) corresponds to one pipeline, each pipette (11) is connected to the at least one liquid pump through the corresponding pipeline, and between each pipette (11) and the at least one liquid pump, it is connected through the corresponding pipeline passing through the inside of the first connecting member (41) and the second connecting member (42).

5. The liquid processing apparatus according to claim 2, wherein The moving member (31) includes a first moving member (311) and a second moving member (312), the driving assembly (32) includes a first driving member (321) and a second driving member (322), the first fixing assembly (33) includes a first fixing bracket (331) and a second fixing bracket (332), and the pipetting assembly (1) further includes a carrying structure (12); The first driving member (321) is connected to the first fixing bracket (331), the second driving member (322) is connected to the second fixing bracket (332), the second fixing bracket (332) is connected to the first moving member (311), and the second moving member (312) is connected to the carrying structure (12); The first driving member (321) is slidably connected to the first moving member (311), and the second driving member (322) is slidably connected to the second moving member (312).

6. The liquid processing apparatus according to claim 2, characterized in that, The liquid processing device further includes a waste liquid collection assembly (6). An induction member is provided on the moving member (31), and at least two induction limit structures are provided on the driving assembly (32). The at least two induction limit structures include a first induction limit structure (315) and a second induction limit structure (316); When the induction member is located at the first induction limit structure (315), the moving member (31) is located at the lower limit moving position, and the liquid transfer assembly (1) is located above the waste liquid collection assembly (6); when the induction member is located at the second induction limit structure (316), the moving member (31) is located at the upper limit moving position.

7. The liquid processing apparatus according to claim 1, wherein, The liquid processing device further includes a second fixing assembly (5). The second fixing assembly (5) includes at least one fixing structure, and each pipeline corresponds to one fixing structure, and each pipeline passes through the corresponding fixing structure.

8. The liquid processing apparatus according to any one of claims 1 to 7, characterized in that, The liquid processing device further includes a waste liquid collection assembly (6) and a base (9). The sample collection assembly (2) and the waste liquid collection assembly (6) are both provided on the base (9), and the liquid transfer assembly (1) is moved to the positions where the sample collection assembly (2) and the waste liquid collection assembly (6) are located respectively through the moving assembly (3); The waste liquid collection assembly (6) includes a waste liquid collection main body (61) and a waste liquid collection channel (62). An opening corresponding to the waste liquid collection channel (62) is provided on the base (9), the waste liquid collection channel (62) passes through the opening, and the waste liquid collection main body (61) is connected to the waste liquid collection channel (62).

9. The liquid treatment device according to any one of claims 1 to 7, characterized in that, The liquid processing device further includes a measuring mechanism (7), a base (9) and a housing (10). The measuring mechanism (7) and the housing (10) are both fixedly provided on the base (9); The sample collection assembly (2) includes a collection container (21) and a receiving groove (22). The collection container (21) is placed in the receiving groove (22). The collection container (21) passes through the housing (10) and is placed in the receiving groove (22). The receiving groove (22) is fixedly connected to the measuring mechanism (7), and the receiving groove (22) and the measuring mechanism (7) are both located inside the housing (10).

10. A detection and analysis system, characterized in that, Including the liquid processing device according to any one of claims 1 to 9.

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