Heparin sodium concentration enzymolysis equipment

Abstract

The utility model relates to the field of heparin sodium processing, in particular to heparin sodium concentration and enzymolysis equipment, which comprises a tank body, a heparin sodium concentration and enzymolysis device, a heparin sodium concentration and enzymolysis device and a heparin sodium concentration and enzymolysis device, the enzymolysis mixing mechanism is arranged in the tank body, the surface of the enzymolysis mixing mechanism extends to the upper end of the tank body, and the motor is mounted at the upper end of the enzymolysis mixing mechanism; wherein the enzymolysis mixing mechanism comprises a mixing assembly arranged in the tank body, and the upper end of the mixing assembly is fixedly connected with an output shaft of a motor; according to the device, agglomerated heparin raw powder can be scattered under the action of the scattering assembly, the agglomerated raw material is scattered and guided through the arc-shaped shifting plate, and the raw material can be quickly guided into the tank body through the round hole in cooperation with the elastic brush and the shifting needle, so that the agglomerated heparin raw powder is quickly scattered and guided into the tank body; furthermore, the enzymolysis effect of the heparin raw powder is guaranteed, and the working efficiency of heparin sodium preparation is kept.

Description

Technical Field

[0001] The utility model relates to the field of heparin sodium processing, and particularly to a heparin sodium concentration enzymolysis device. Background Technique

[0002] Heparin sodium is an important anticoagulant drug, and its active ingredient is heparin, which is an anionic glycosaminoglycan sulfate and widely exists on the surface of main cells; heparin sodium mainly exerts an anticoagulant effect by binding to antithrombin III (AT-III) and enhancing the inhibitory effect of the latter on activated coagulation factors II, IX, X, XI, and XII.

[0003] The concentration enzymolysis of heparin sodium is an important link in the production process of heparin sodium. Enzymolysis is a process of hydrolyzing heparin crude powder with specific enzymes, aiming to release heparin from its complex with proteins to obtain heparin sodium. Among them, heparin crude powder is a complex polysaccharide compound extracted from animal tissues (such as porcine intestinal mucosa) and has a strong anticoagulant effect. Due to the presence of a large number of hydrophilic groups such as sulfate groups and uronic acid in its molecular structure, heparin crude powder has a certain solubility in water.

[0004] The heparin crude powder may undergo changes in its molecular structure under the action of enzymes during preparation or storage, and then form lumps. After retrieving the prior art "an enzymolysis extraction device for heparin sodium processing" with the publication number "CN213357602U", the device is simple to disassemble and assemble, which is convenient for staff to carry out rapid assembly and maintenance work. However, enzymolysis of agglomerated heparin crude powder will reduce the enzymolysis effect and affect the working efficiency of heparin sodium preparation.

[0005] Therefore, a heparin sodium concentration enzymolysis device is proposed to solve the above problems. Content of the Utility Model

[0006] The purpose of the utility model is to provide a heparin sodium concentration enzymolysis device to solve the above problems, and improve the problem that enzymolysis of agglomerated heparin crude powder will reduce the enzymolysis effect and affect the working efficiency of heparin sodium preparation.

[0007] The present utility model realizes the above object through the following technical solutions. A heparin sodium concentration enzymolysis device includes: a tank body, and a motor is arranged at the upper end of the tank body; an enzymolysis mixing mechanism, the enzymolysis mixing mechanism is arranged inside the tank body, the surface of the enzymolysis mixing mechanism extends to the upper end of the tank body, and the motor is installed at the upper end of the enzymolysis mixing mechanism; wherein, the enzymolysis mixing mechanism includes a mixing component arranged inside the tank body, the upper end of the mixing component is fixedly connected with the output shaft of the motor, a dispersing component is installed on the surface of the mixing component, the dispersing component is arranged at the upper end of the tank body, the motor is installed at the upper end of the dispersing component, and a feed inlet is embeddedly installed on the surface of the dispersing component.

[0008] Preferably, the dispersing component includes a top cavity installed at the upper end of the tank body, the motor is fixedly connected to the upper end of the top cavity, a plurality of round holes are opened at the lower end of the top cavity, and the plurality of round holes are annularly distributed along the lower end of the top cavity. A plurality of elastic brushes are fixedly connected to the inner top wall of the top cavity. An arc-shaped baffle installed on the surface of the mixing component is arranged inside the top cavity. The heparin crude powder is injected into the inside of the top cavity through the feed inlet. At this time, the driving motor drives the mixing component to rotate. At this time, the raw materials inside the top cavity are stirred by the arc-shaped baffle, so that the agglomerated raw materials are gradually dispersed. At the same time, the dispersed raw materials move towards the round holes under the action of the arc of the lower tube surface and finally enter the inside of the tank body through the round holes for mixing and processing. When the elastic brush is stirred by the arc-shaped baffle and returns to its original position, it assists in dispersing the agglomerated heparin crude powder.

[0009] Preferably, the mixing component includes a rotating shaft rotatably connected to the inner bottom wall of the tank body. The upper end of the rotating shaft penetrates through the top cavity and is fixedly connected to the output shaft of the motor. Stirring rods are fixedly connected to the surface of the rotating shaft near the inner bottom wall of the tank body. A plurality of blade plates are fixedly connected to the surface of the rotating shaft, and the plurality of blade plates are annularly distributed. An arc-shaped top fixedly connected to the surface of the rotating shaft is arranged at the upper end of the blade plate. Among them, the rotating shaft rotates driven by the motor, and at the same time, the raw materials inside the tank body are mixed by the stirring rods, and the blade plates will be driven to rotate synchronously.

[0010] Preferably, the lower end of the arc-shaped baffle is in contact with the inner bottom wall of the top cavity. A connecting plate is fixedly connected to the concave surface of the arc-shaped baffle. A vertical rod is fixedly connected to the lower end of the connecting plate, and a contact rubber block is fixedly connected to the lower end of the vertical rod. Among them, a notch is arranged at the position of the arc-shaped baffle above the round hole, so that the raw materials remain above the round hole through the notch, which is convenient for the raw materials to enter the tank body.

[0011] Preferably, the inner wall of the circular hole is fixedly connected to a soft rubber positioning seat, and the inner wall of the soft rubber positioning seat is clamped with a dial pin, and the upper and lower ends of the dial pin both penetrate to the outside of the circular hole, and the lower end of the interference rubber block contacts the surface of the adjacent dial pin. When the raw material is located above the circular hole and enters the inside of the circular hole, if accumulation occurs inside the circular hole, the interference rubber block triggers the dial pin to reduce the accumulation of material inside the circular hole, and the material of the soft rubber positioning seat is made of soft rubber material, which itself has a certain elasticity.

[0012] Preferably, the outer edge of the blade is fixedly connected to a lower tube, the longitudinal cross-section of the lower tube is conical, the upper end of the lower tube is fixedly connected to an upper tube, the longitudinal cross-section of the upper tube is rectangular, and the lower tube cooperates with the blade to guide the liquid fused inside the tank body to the upper tube and spray it below the arc-shaped top through the upper tube.

[0013] Preferably, a plurality of swinging rubber plates are fixedly connected to the lower end of the arc-shaped top, and the swinging rubber plates are arc-shaped. The swinging rubber plates are located above the upper tube, and the liquid sprayed toward the arc-shaped top is swung toward the inner wall of the tank through the plurality of swinging rubber plates, and the swung liquid contacts the raw material falling from the circular hole.

[0014] The beneficial effects of the utility model are:

[0015] 1. The above-mentioned heparin sodium concentrated enzymatic hydrolysis equipment can break up the clumped heparin raw powder under the action of the breaking up component. The device uses a curved plate to break up and guide the clumped raw material. The elastic brush and the moving needle allow the raw material to pass through the circular hole and be guided into the tank body quickly, so that the clumped heparin raw powder is quickly broken up and guided into the tank body, thereby ensuring the enzymatic hydrolysis effect of the heparin raw powder and maintaining the efficiency of heparin sodium preparation.

[0016] 2. By setting up a mixing component, the drug powder in the enzymatic hydrolysis process can be mixed under the action of the mixing component. The device has multiple swinging rubber plates that swing the liquid sprayed onto the arc-shaped top toward the inner wall of the tank. The swung liquid contacts the raw materials falling from the circular hole, so that the drug powder can form a preliminary fusion effect before contacting the liquid, thereby improving the stability of the fusion during the enzymatic hydrolysis process. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a structural diagram of the utility model;

[0018] Figure 2 This is a schematic diagram of the internal structure of the tank body of the present utility model;

[0019] Figure 3 This is a schematic diagram of the elastic brush distribution of the present utility model;

[0020] Figure 4 This is a schematic diagram of the connection between the vertical rod and the friction rubber block of the utility model;

[0021] Figure 5 This is an exploded cross-sectional view of the circular hole of the utility model;

[0022] Figure 6 This is a schematic diagram of the local structure of the mixing component of the present invention.

[0023] In the figure: 1. Tank body; 2. Motor; 3. Enzymatic hydrolysis and mixing mechanism; 31. Breaking up component; 311. Top cavity; 312. Round hole; 313. Elastic brush; 314. Arc-shaped dial plate; 315. Connecting plate; 316. Vertical rod; 317. Resistance rubber block; 318. Soft rubber positioning seat; 319. Dial needle; 32. Mixing component; 321. Rotating shaft; 322. Stirring rod; 323. Arc-shaped top; 324. Blade; 325. Lower tube; 326. Upper tube; 327. Swinging rubber plate; 33. Feed inlet. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0025] When implementing: Figure 1-6 As shown, a sodium heparin concentration and enzymatic hydrolysis device comprises: a tank body 1, a motor 2 is provided at the upper end of the tank body 1; an enzymatic hydrolysis and mixing mechanism 3, the enzymatic hydrolysis and mixing mechanism 3 is arranged inside the tank body 1, the surface of the enzymatic hydrolysis and mixing mechanism 3 extends to the upper end of the tank body 1, and the motor 2 is installed at the upper end of the enzymatic hydrolysis and mixing mechanism 3; wherein, the enzymatic hydrolysis and mixing mechanism 3 comprises a mixing assembly 32 arranged inside the tank body 1, the upper end of the mixing assembly 32 is fixedly connected to the output shaft of the motor 2, a breaking assembly 31 is installed on the surface of the mixing assembly 32, the breaking assembly 31 is arranged at the upper end of the tank body 1, the motor 2 is installed at the upper end of the breaking assembly 31, and a feed port 33 is embedded in the surface of the breaking assembly 31;

[0026] like Figures 1-5As shown, the breaking up component 31 includes a top chamber 311 installed at the upper end of the tank body 1, the motor 2 is fixedly connected to the upper end of the top chamber 311, the lower end of the top chamber 311 is provided with a plurality of circular holes 312, and the plurality of circular holes 312 are distributed in a ring shape along the lower end of the top chamber 311, and the inner top wall of the top chamber 311 is fixedly connected with a plurality of elastic brushes 313, and the top chamber 311 is provided with an arc-shaped paddle 314 installed on the surface of the mixing component 32, and the lower end of the arc-shaped paddle 314 is aligned with the upper end of the top chamber 311. The inner bottom wall is in contact, the inner concave surface of the arc-shaped dial plate 314 is fixedly connected to the connecting plate 315, the lower end of the connecting plate 315 is fixedly connected to the vertical rod 316, the lower end of the vertical rod 316 is fixedly connected to the interference rubber block 317, the inner wall of the circular hole 312 is fixedly connected to the soft rubber positioning seat 318, the inner wall of the soft rubber positioning seat 318 is clamped with a dial pin 319, the upper and lower ends of the dial pin 319 both pass through the outside of the circular hole 312, and the lower end of the interference rubber block 317 contacts the surface of the adjacent dial pin 319;

[0027] The feed port 33 injects raw heparin powder into the top chamber 311. The drive motor 2 then drives the mixing assembly 32 to rotate. The curved paddle 314 stirs the raw material inside the top chamber 311, gradually breaking up any clumped raw material. Simultaneously, the scattered raw material, influenced by the curvature of the lower tube 325, moves toward the circular hole 312, ultimately passing through the circular hole 312 and guiding it into the tank body 1 for mixing. The elastic brush 313, moved by the curved paddle 314 and reset, assists in breaking up the clumped raw heparin powder. The curved paddle 314 has a notch above the circular hole 312, allowing the raw material to remain above the circular hole 312 through the notch, facilitating its entry into the tank body 1. When the raw material is located above the circular hole 312 and enters the circular hole 312, if accumulation occurs inside the circular hole 312, the friction rubber block 317 triggers the shifting pin 319 to reduce the accumulation of the material inside the circular hole 312. The soft rubber positioning seat 318 is made of soft rubber material, which has a certain degree of elasticity.

[0028] like Figure 1 、 Figure 2 、 Figure 3 and Figure 6As shown, the mixing assembly 32 includes a rotating shaft 321 rotatably connected to the inner bottom wall of the tank body 1, the upper end of the rotating shaft 321 passes through the top cavity 311 and is fixedly connected to the output shaft of the motor 2, the surface of the rotating shaft 321 close to the inner bottom wall of the tank body 1 is fixedly connected to a stirring rod 322, the surface of the rotating shaft 321 is fixedly connected to a plurality of blades 324, the plurality of blades 324 are distributed in a ring shape, the upper end of the blade 324 is provided with an arc-shaped top 323 fixedly connected to the surface of the rotating shaft 321, the outer edge of the blade 324 is fixedly connected to a lower tube 325, the longitudinal cross-section of the lower tube 325 is conical, the upper end of the lower tube 325 is fixedly connected to an upper tube 326, the longitudinal cross-section of the upper tube 326 is rectangular, the lower end of the arc-shaped top 323 is fixedly connected to a plurality of swinging rubber plates 327, the swinging rubber plates 327 are arc-shaped, and the swinging rubber plates 327 are located above the upper tube 326;

[0029] Driven by motor 2, shaft 321 rotates, mixing the ingredients within tank 1 via agitator 322 and simultaneously driving blades 324 to rotate. Lower tube 325, in conjunction with blades 324, guides the fused liquid within tank 1 toward upper tube 326, where it is ejected below curved top 323. Multiple swinging rubber plates 327 swing the liquid toward curved top 323 toward the inner wall of tank 1, where it comes into contact with the ingredients that have fallen from circular hole 312.

[0030] When the utility model is in use, the raw heparin powder is injected into the top cavity 311, the driving motor 2 drives the rotating shaft 321 to rotate, the rotating shaft 321 rotates under the drive of the motor 2, the stirring rod 322 mixes the raw materials inside the tank body 1, and synchronously drives the blade 324 to follow the synchronous rotation, the arc-shaped paddle 314 pokes the raw materials inside the top cavity 311, and the arc-shaped paddle 314 is provided with a notch above the circular hole 312, and the raw materials are kept above the circular hole 312 through the notch, and the raw materials are kept in the position of After passing above the circular hole 312, it enters the circular hole 312 and triggers the dial pin 319 by resisting the rubber block 317, thereby reducing the accumulation of materials inside the circular hole 312. The lower tube 325 cooperates with the blade 324 to guide the fused liquid inside the tank body 1 to the upper tube 326. The upper tube 326 sprays out from the bottom of the curved top 323. The swinging rubber plate 327 swings the liquid sprayed toward the curved top 323 toward the inner wall of the tank body 1, and the swung liquid comes into contact with the raw materials dropped from the circular hole 312.

[0031] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A heparin sodium concentration and enzymatic hydrolysis device, characterized in that, include: A tank body (1), wherein a motor (2) is provided at the upper end of the tank body (1); An enzymatic hydrolysis and mixing mechanism (3), wherein the enzymatic hydrolysis and mixing mechanism (3) is arranged inside the tank body (1), the surface of the enzymatic hydrolysis and mixing mechanism (3) extends to the upper end of the tank body (1), and the motor (2) is installed at the upper end of the enzymatic hydrolysis and mixing mechanism (3); The enzymatic hydrolysis mixing mechanism (3) includes a mixing assembly (32) arranged inside the tank body (1), the upper end of the mixing assembly (32) is fixedly connected to the output shaft of the motor (2), a breaking up assembly (31) is installed on the surface of the mixing assembly (32), the breaking up assembly (31) is arranged at the upper end of the tank body (1), the motor (2) is installed at the upper end of the breaking up assembly (31), and a feed port (33) is embedded and installed on the surface of the breaking up assembly (31).

2. The heparin sodium concentration enzymatic hydrolysis device according to claim 1, wherein: The breaking up assembly (31) comprises a top chamber (311) mounted on the upper end of the tank body (1); the motor (2) is fixedly connected to the upper end of the top chamber (311); a plurality of circular holes (312) are provided at the lower end of the top chamber (311); the plurality of circular holes (312) are distributed in a ring shape along the lower end of the top chamber (311); a plurality of elastic brushes (313) are fixedly connected to the inner top wall of the top chamber (311); and an arc-shaped paddle (314) mounted on the surface of the mixing assembly (32) is provided inside the top chamber (311).

3. A heparin sodium concentration enzymatic hydrolysis device according to claim 2, characterized in that: The mixing assembly (32) comprises a rotating shaft (321) rotatably connected to the inner bottom wall of the tank body (1); the upper end of the rotating shaft (321) passes through the top cavity (311) and is fixedly connected to the output shaft of the motor (2); a stirring rod (322) is fixedly connected to the surface of the rotating shaft (321) close to the inner bottom wall of the tank body (1); a plurality of blades (324) are fixedly connected to the surface of the rotating shaft (321); the plurality of blades (324) are distributed in a ring shape, and the upper ends of the blades (324) are provided with arc-shaped tops (323) fixedly connected to the surface of the rotating shaft (321).

4. A heparin sodium concentration enzymatic hydrolysis device according to claim 2, characterized in that: The lower end of the arc-shaped shifting plate (314) contacts the inner bottom wall of the top cavity (311); the inner concave surface of the arc-shaped shifting plate (314) is fixedly connected to a connecting plate (315); the lower end of the connecting plate (315) is fixedly connected to a vertical rod (316); and the lower end of the vertical rod (316) is fixedly connected to a resisting rubber block (317).

5. A heparin sodium concentration enzymatic hydrolysis device according to claim 4, characterized in that: The inner wall of the circular hole (312) is fixedly connected to a soft rubber positioning seat (318), and the inner wall of the soft rubber positioning seat (318) is clamped with a shifting pin (319), and the upper and lower ends of the shifting pin (319) are both inserted into the outside of the circular hole (312), and the lower end of the abutting rubber block (317) contacts the surface of the adjacent shifting pin (319).

6. The heparin sodium concentration enzymatic hydrolysis equipment according to claim 3, characterized in that: The outer edge of the blade (324) is fixedly connected to a lower tube (325), the longitudinal section of the lower tube (325) is conical, and the upper end of the lower tube (325) is fixedly connected to an upper tube (326), the longitudinal section of the upper tube (326) is rectangular.

7. The heparin sodium concentration and enzymatic hydrolysis equipment according to claim 6, characterized in that: A lower end of the arc-shaped top (323) is fixedly connected with a plurality of swinging rubber plates (327). The swinging rubber plates (327) are arc-shaped, and the swinging rubber plates (327) are located above the upper pipe (326).

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