Detection device for serum sample

Abstract

The utility model discloses a detection device for a serum sample, which comprises a sample detection box, the surface of the sample detection box is rotatably connected with a sealing door, an auxiliary mechanism is arranged in the sample detection box, and the utility model relates to the technical field of serum detection devices. According to the detection device for the serum sample, a PLC is fixedly connected to the interior and exterior of the sample detection box, movement of piston rods of two air cylinders in the sample detection box is controlled through the PLC, then accurate dropping of a reagent in a test tube can be achieved through programming, and a slidable driving block is arranged in the sample detection box, so that accurate dropping of the reagent in the test tube is achieved. The driving block moves downwards to drive the sealing block to anticlockwise rotate by 90 degrees, so that the cover in the sealing block can be accurately contacted with a test tube opening in the test tube box and is directly contacted with a test tube under the action of rotating force, the test tube is primarily sealed, and the influence of the external environment on the reaction of serum and a reagent after the sample detection box is opened is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of serum detection devices, and specifically relates to a detection device for serum samples. Background Technique

[0002] Brain aneurysms are pathological focal dilations of the cerebrovascular system, most commonly found at the bifurcations of large intracranial arteries. According to statistics, the global adult incidence rate is about 2%-6%. The average age of patients with aneurysmal subarachnoid hemorrhage is 55 years old, and its lethality and disability rate are high; the inflammatory response is an important part of the occurrence, development, and rupture of brain aneurysms, and proteins, antibodies, metabolic molecules, etc. in the serum will all change accordingly.

[0003] According to the patent document with the retrieval announcement number CN218782283U, a detection device for serum samples for detecting PTX resistance in tumor patients is disclosed, including a box body. A control component is installed at the lower end inside the box body, and a support platform is slidably connected inside the box body through the control component. The utility model adopts the above structure. By putting the serum sample and the required reagents into the dropping module, and placing the reagent kit on the support platform, then starting the air purification module to purify the air in the box body, avoiding the air in the box body containing harmful substances from affecting the detection result of the serum sample. Subsequently, the position of the dropping module can be adjusted through the moving component, the position of the support platform can be adjusted through the control component, and the position of the support platform can be stabilized through the sliding component, so that the position of the reagent kit can be adjusted through the support platform to facilitate dropping the serum sample and the reagents into the reagent kit, not only avoiding the influence of external environmental factors on the detection result, but also making the detection work of PTX resistance cleaner and more hygienic.

[0004] However, when implementing the above technical solutions, there are the following problems: The above solutions can ensure that the detection work is cleaner and more hygienic by purifying the air and maintaining airtightness. However, in the above device, it is difficult to seal the sample tube after the reagent is dropped into the serum sample, and it is necessary to open the outer box body of the device for sealing operations, resulting in unpurified air flowing into the inside of the box body and the sample tube, which will also be affected by external environmental factors on the detection structure. Moreover, during the detection process of serum samples for brain aneurysm markers screened by phage display and high-throughput second-generation sequencing technology, reagents need to be dropped multiple times and placed in a magnetic rotator in a 4°C cold storage for mixing, and sealing needs to be performed multiple times, making it difficult to ensure that external factors do not affect the detection result. Therefore, the utility model provides a detection device for serum samples. Content of the Utility Model

[0005] In response to the shortcomings of the existing technology, the utility model provides a detection device for serum samples, which solves the problem that after the serum sample detection device adds reagents, the sample tube is not directly sealed inside the box. The experiment of detecting cerebral aneurysm markers requires multiple drops, so it is difficult to ensure that external environmental factors do not affect the test results by removing the seal multiple times.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solutions: a serum sample detection device, comprising a sample detection box, the surface of the sample detection box is rotatably connected to a sealing door, the interior of the sample detection box is provided with an auxiliary mechanism, the auxiliary mechanism is used to assist in the dripping of reagents inside the sample detection box and the sealing of test tubes, the auxiliary mechanism includes a sealing block rotatably connected to the interior of the sample detection box, the surface of the sample detection box is fixedly connected to a PLC controller, the interior of the sample detection box is fixedly connected to a cylinder, an air purifier and a limit spring, the interior of the sample detection box is slidably connected to a dropper module and a test tube box via a cylinder, and the interior of the sample detection box is slidably connected to An operating block and a clamping rod are connected, and a placement groove is provided on the surface of the sealing block and the test tube box. A contact block is slidably connected to the inside of the placement groove, and a contact spring is fixedly connected between the contact block and the placement groove. The inside of the sealing block is slidably connected to the elastic rod through a moving component, and the inside of the sealing block is fixedly connected to a rotating rod. The inside of the sample detection box is slidably connected to the driving block, and the surface of the driving block is fixedly connected to the driving rod. The inside of the sample detection box is rotatably connected to the driving column, and a driving component is provided between the driving rod and the driving column. The inside of the sample detection box is rotatably connected to the transfer block through a synchronization component and the driving column, and the inside of the sample detection box is rotatably connected to the reversing block through a reversing component and the transfer block.

[0007] Preferably, the sliding assembly includes a sliding shaft fixed on the surfaces of the operating block and the clamping rod, and a sliding groove is provided inside the sample detection box.

[0008] Preferably, the moving assembly includes a moving shaft fixed on the surface of the elastic rod, a moving groove is provided inside the sealing block, and a moving spring is fixedly connected to the opposite side of the moving shaft and the moving groove.

[0009] Preferably, the driving assembly includes a driving shaft fixed to the surface of the driving rod, and a driving groove is provided inside the driving column.

[0010] Preferably, the synchronization assembly includes synchronization wheels fixed on the surfaces of the driving column and the transfer block, and a synchronization belt is connected between the synchronization wheels.

[0011] Preferably, the reversing assembly comprises transfer bevel teeth fixed on the surface of the transfer block, and the surface of the reversing block is fixedly connected with the reversing bevel teeth.

[0012] Beneficial effects

[0013] The utility model provides a detection device for serum samples. Compared with the prior art, it has the following

[0014] Beneficial effects:

[0015] (1). For the detection device for serum samples, by fixedly connecting a PLC controller inside and outside the sample detection box, controlling the movement of the piston rods of two cylinders inside the sample detection box through the PLC controller, the accurate dropping of reagents into the test tube can be achieved through programming. And a slidable driving block is arranged inside the sample detection box. The downward movement of the driving block can drive the sealing block to rotate counterclockwise by 90 degrees. Then, the cover in the sealing block can accurately contact the opening of the test tube inside the test tube box and directly contact the test tube under the action of the rotating force, realizing the preliminary sealing of the test tube and avoiding the influence of the external environment on the reaction between the serum and the reagent after the sample detection box is opened.

[0016] (2). For the detection device for serum samples, by opening a sliding groove inside the sample detection box, restricting the sliding direction and distance of the operating block and the clamping rod through the sliding groove, the operation of the position of the sealing block and the sealing of this area can be quickly realized through the operating block and the clamping rod. And a synchronous component and a commutation component are arranged inside the sample detection box. Then, the rotation of the driving column at the bottom of the sample detection box can be converted into the rotation of the middle rotating rod, realizing the rotation of the upper components driven by the movement. Then, the sealing block can rotate after the test tube box moves to a suitable position, effectively ensuring the sealing of the test tube port. Description of the drawings

[0017] Figure 1 is the front structural view of the utility model;

[0018] Figure 2 is the front structural view of the test tube box of the utility model;

[0019] Figure 3 is of the utility model Figure 2 partial enlarged structural view of A in;

[0020] Figure 4 is the left structural view of the rotating rod of the utility model.

[0021] In the figure: 1 - sample detection box, 2 - sealing door, 3 - auxiliary mechanism, 31 - sealing block, 32 - PLC controller, 33 - sliding assembly, 331 - sliding shaft, 332 - sliding groove, 34 - moving assembly, 341 - moving shaft, 342 - moving groove, 343 - moving spring, 35 - driving assembly, 351 - driving shaft, 352 - driving groove, 36 - synchronization assembly, 361 - synchronization pulley, 362 - synchronization belt, 37 - commutation assembly, 371 - transfer bevel gear, 372 - commutation bevel gear, 38 - cylinder, 39 - air purifier, 310 - limiting spring, 311 - dropping agent module, 312 - test tube box, 313 - operating block, 314 - clamping rod, 315 - placing groove, 316 - contact block, 317 - contact spring, 318 - elastic rod, 319 - rotating rod, 320 - driving block, 321 - driving rod, 322 - driving column, 323 - transfer block, 324 - commutation block. Specific implementation manners

[0022] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts shall fall within the protection scope of the present invention.

[0023] Please refer to Figures 1-4 , the present invention provides two technical solutions:

[0024] Embodiment 1

[0025] A detection device for serum samples, comprising a sample detection box 1, a sealing door 2 is rotatably connected to the surface of the sample detection box 1, an auxiliary mechanism 3 is arranged inside the sample detection box 1, and the auxiliary mechanism 3 is used to assist in realizing the dropping of reagents inside the sample detection box 1 and the sealing of test tubes. The auxiliary mechanism 3 includes a sealing block 31 rotatably connected to the inside of the sample detection box 1. A PLC controller 32 is fixedly connected to the surface of the sample detection box 1. An air cylinder 38, an air purifier 39 and a limit spring 310 are fixedly connected to the inside of the sample detection box 1. The air valve of the air cylinder 38 is electrically connected to the output end of the PLC controller 32. The air purifier 39 refers to a product that can adsorb, decompose or convert various air pollutants and effectively improve air cleanliness. A dropping agent module 311 and a test tube box 312 are slidably connected to the inside of the sample detection box 1 through the air cylinder 38. The structure of the dropping agent module 311 is the same as that of the dropping agent module in the reference patent solution and can drop reagents downward. An operating block 313 and a clamping rod 314 are slidably connected to the inside of the sample detection box 1 through a sliding component 33. Placing grooves 315 are formed on the surfaces of the sealing block 31 and the test tube box 312. A contact block 316 is slidably connected to the inside of the placing groove 315. A contact spring 317 is fixedly connected between the contact block 316 and the placing groove 315. A resilient rod 318 is slidably connected to the inside of the sealing block 31 through a moving component 34. Adjacent resilient rods 318 are located on different vertical planes and will not intersect during movement. A rotating rod 319 is fixedly connected to the inside of the sealing block 31. A driving block 320 is slidably connected to the inside of the sample detection box 1. A driving rod 321 is fixedly connected to the surface of the driving block 320. One end of the driving rod 321 is in contact with one end of the limit spring 310. A driving column 322 is rotatably connected to the inside of the sample detection box 1. A driving component 35 is arranged between the driving rod 321 and the driving column 322, and the driving component 35 is used to realize the rotation of the driving column 322. A transfer block 323 is rotatably connected to the inside of the sample detection box 1 through a synchronization component 36 and the driving column 322. A reversing block 324 is rotatably connected to the inside of the sample detection box 1 through a reversing component 37 and the transfer block 323. A synchronization component 36 is also arranged between the reversing block 324 and the rotating rod 319. A PLC controller 32 is fixedly connected inside and outside the sample detection box 1. By controlling the movement of the piston rods of the two air cylinders 38 inside the sample detection box 1 through the PLC controller 32, the precise dropping of reagents into the test tubes can be realized through programming. And a slidable driving block 320 is arranged inside the sample detection box 1. The downward movement of the driving block 320 can drive the sealing block 31 to rotate counterclockwise by 90 degrees. Then the cover in the sealing block 31 can precisely contact the opening of the test tube inside the test tube box 312 and directly contact the test tube under the action of the rotating force, realizing the preliminary sealing of the test tube and avoiding the influence of the external environment on the reaction between the serum and the reagents after the sample detection box 1 is opened.

[0026] Embodiment Two

[0027] The main differences from Example 1 are:

[0028] A detection device for serum samples, wherein the sliding assembly 33 includes a sliding shaft 331 fixed on the surface of the operating block 313 and the card rod 314, a sliding groove 332 is provided inside the sample detection box 1, and the surface of the sliding shaft 331 is slidably connected to the inner surface of the sliding groove 332, the moving assembly 34 includes a moving shaft 341 fixed on the surface of the elastic rod 318, a moving groove 342 is provided inside the sealing block 31, a moving spring 343 is fixedly connected to the opposite side of the moving shaft 341 and the moving groove 342, the surface of the moving shaft 341 is slidably connected to the inner surface of the moving groove 342, the driving assembly 35 includes a driving shaft 351 fixed on the surface of the driving rod 321, a driving groove 352 is provided inside the driving column 322, the surface of the driving shaft 351 is slidably connected to the inner surface of the driving groove 352, the driving groove 352 is arc-shaped and has a rotation angle of 90 degrees, and the synchronization assembly 36 includes a synchronization member fixed on the surface of the driving column 322 and the transfer block 323. A synchronous belt 362 is connected between the step wheel 361 and the synchronous wheel 361. The reversing assembly 37 includes a transfer bevel gear 371 fixed to the surface of the transfer block 323. The surface of the reversing block 324 is fixedly connected to the reversing bevel gear 372. The surface of the transfer bevel gear 371 meshes with the surface of the reversing bevel gear 372. A sliding groove 332 is provided inside the sample testing box 1. The sliding groove 332 limits the sliding direction and distance of the operating block 313 and the locking rod 314. The operating block 313 and the locking rod 314 can quickly achieve the operation of the position of the sealing block 31 and the sealing of the area. In addition, the synchronization assembly 36 and the reversing assembly 37 are provided inside the sample testing box 1, so that the rotation of the driving column 322 at the bottom of the sample testing box 1 can be converted into the rotation of the middle rotating rod 319, so that the upper component can be driven by the movement. Then, the sealing block 31 can rotate after the test tube box 312 moves to the appropriate position, which can effectively ensure that the test tube port is sealed.

[0029] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0030] During operation, first place the serum to be tested inside the test tube box 312, place a suitable lid in the placement groove 315 inside the sealing block 31, then pull out the clamping rod 314 outward, slide the operation block 313 downward, and rotate the sealing block 31 to seal the sample detection box 1. Start the air purifier 39. After a period of time, control the cylinder 38 to drive the dropper module 311 and the test tube box 312 to move through the PLC controller 32. The test tube box 312 continuously moves to the right, and the dropper module 311 drops the reagent into the corresponding sample test tubes. When all the samples inside the test tube box 312 have been dropped with the reagent, the cylinder 38 controls the dropper module 311 to move upward. After the dropper module 311 moves upward, move the test tube box 312 to the right again. At this time, it will drive the drive block 320 to move downward. The movement of the drive block 320 will drive the drive column 322 to rotate 90 degrees inside the sample detection box 1 through the drive rod 321. The rotation of the drive column 322 will drive the rotation rod 319 to rotate through the synchronization component 36 and the commutation component 37. Furthermore, the sealing block 31 rotates above the test tube box 312, the test tube contacts the elastic rod 318, and the downward movement of the sealing block 31 will cause the elastic rod 318 to move to both sides, and the lid moves to one end of the test tube for preliminary sealing. When taking out the test tube after stopping the reagent dropping, the lid can be pressed or rotated to stably fix the lid and the test tube, and then the next experiment can be carried out.

[0031] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variation thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.

[0032] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A detection device for serum samples, comprising a sample detection box (1), characterized in that: A sealing door (2) is rotatably connected to the surface of the sample detection box (1). An auxiliary mechanism (3) is arranged inside the sample detection box (1), and the auxiliary mechanism (3) is used to assist in the dropping of reagents inside the sample detection box (1) and the sealing of test tubes. The auxiliary mechanism (3) includes a sealing block (31) rotatably connected to the inside of the sample detection box (1). A PLC controller (32) is fixedly connected to the surface of the sample detection box (1). An air cylinder (38), an air purifier (39), and a limit spring (310) are fixedly connected to the inside of the sample detection box (1). A dropping agent module (311) and a test tube box (312) are slidably connected to the inside of the sample detection box (1) through the air cylinder (38). An operation block (313) and a clamping rod (314) are slidably connected to the inside of the sample detection box (1) through a sliding component (33). Placing grooves (315) are formed on the surfaces of the sealing block (31) and the test tube box (312). A contact block (316) is slidably connected to the inside of the placing groove (315). A contact spring (317) is fixedly connected between the contact block (316) and the placing groove (315). A resilient rod (318) is slidably connected to the inside of the sealing block (31) through a moving component (34). A rotating rod (319) is fixedly connected to the inside of the sealing block (31). A driving block (320) is slidably connected to the inside of the sample detection box (1). A driving rod (321) is fixedly connected to the surface of the driving block (320). A driving column (322) is rotatably connected to the inside of the sample detection box (1). A driving component (35) is arranged between the driving rod (321) and the driving column (322). A transfer block (323) is rotatably connected to the inside of the sample detection box (1) through a synchronization component (36) and the driving column (322). A reversing block (324) is rotatably connected to the inside of the sample detection box (1) through a reversing component (37) and the transfer block (323).

2. The detection device for a serum sample according to claim 1, wherein: The sliding component (33) includes sliding shafts (331) fixed to the surfaces of the operation block (313) and the clamping rod (314). A sliding groove (332) is formed inside the sample detection box (1).

3. The detection device for a serum sample according to claim 1, characterized in that: The moving component (34) includes a moving shaft (341) fixed to the surface of the resilient rod (318). A moving groove (342) is formed inside the sealing block (31). A moving spring (343) is fixedly connected to the opposite sides of the moving shaft (341) and the moving groove (342).

4. The detection device for serum samples according to claim 1, wherein: The driving component (35) includes a driving shaft (351) fixed to the surface of the driving rod (321). A driving groove (352) is formed inside the driving column (322).

5. The detection device for a serum sample according to claim 1, wherein: The synchronization component (36) includes synchronizing wheels (361) fixed to the surfaces of the driving column (322) and the transfer block (323). A timing belt (362) is connected in transmission between the synchronizing wheels (361).

6. The detection device for serum samples according to claim 1, wherein: The commutation assembly (37) includes a commutation bevel gear (371) fixed to the surface of the transfer block (323), and a commutation bevel gear (372) is fixedly connected to the surface of the commutation block (324).

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