Ionization sample introduction platform device for mass spectrometer

Abstract

The utility model discloses an ionization sample injection platform device for a mass spectrometer. The ionization sample injection platform device comprises a base, and a rotary sample frame, a swing arm grabbing mechanism, a turnover sample injection port mechanism and a high-voltage applying mechanism which are arranged on the base, the rotary sample frame is used for loading a plurality of to-be-tested samples; a sample to be detected is arranged in the suction head; the swing arm grabbing mechanism is used for taking and placing a to-be-tested sample through lifting and rotating actions of an electric gripper; the overturning sample inlet mechanism is arranged at the detection port of the mass spectrometer and is used for controlling the to-be-detected sample to execute an overturning action, so that the to-be-detected sample is aligned with the tip part of the detection port of the mass spectrometer; the high-voltage electricity applying mechanism is used for releasing high-voltage electricity to the tip end of the suction head. The ionization sample introduction platform device structure for the mass spectrometer enters a field, and the detection efficiency can be remarkably improved.

Description

Technical Field

[0001] The utility model relates to an ionization injection platform device for a mass spectrometer. Background Art

[0002] Currently, mass spectrometers are frequently used to: Detect components in biological samples, such as proteins, amino acids, and nucleic acids; Detect harmful substances in environmental samples such as air, water, and soil; Detect pesticide residues and additives in food; and Detect biomarkers to assist in disease diagnosis and treatment. As an important supplement and alternative to mass spectrometer experiments, ionization experiments are often more suitable for rapid sample analysis and on-site testing, improving experimental results and the accuracy of data analysis. Currently, the most common ionization experiment method in laboratories is for the experimenter to manually generate a high-voltage electric field to treat the object to be tested. This method is cumbersome and inefficient, and manual errors can easily lead to poor experimental results and inaccurate data.

[0003] Therefore, it is necessary to design a new type of ionization injection platform device for mass spectrometer. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide an ionization sampling platform device for a mass spectrometer. The ionization sampling platform device for a mass spectrometer has multiple detection positions and can achieve efficient detection.

[0005] The technical solutions of the utility model are as follows:

[0006] An ionization injection platform device for a mass spectrometer comprises a base and a rotating sample rack arranged on the base, a swing arm grasping mechanism, a flip injection port mechanism and a high voltage electricity applying mechanism;

[0007] The rotating sample rack is used to load a plurality of samples to be tested; the samples to be tested are placed in the pipette tip;

[0008] The swing arm gripping mechanism is used to pick up and place the sample to be tested by lifting and rotating the electric gripper; the flip injection port mechanism is set at the mass spectrometer detection port and is used to control the sample to be tested to perform a flip action so that the sample to be tested is aligned with the tip of the mass spectrometer detection port;

[0009] The high-voltage electricity applying mechanism is used to release high-voltage electricity to the tip of the suction head.

[0010] The rotating sample rack comprises a driving mechanism and a disc; the disc has an outer ring and an inner ring placement position; the driving mechanism drives the disc to rotate through a first motor and a synchronous belt transmission unit.

[0011] The swing arm grabbing mechanism includes a swing arm, a swing arm bracket support plate, a swing arm shaft, a swing arm rotation drive mechanism,

[0012] Swing arm lifting drive mechanism and electric gripper;

[0013] The swing arm rotation drive mechanism includes a second motor and a synchronous belt transmission unit, which is used to drive the swing arm to rotate (i.e. swing);

[0014] The swing arm lifting drive mechanism includes a third motor, a Z-axis guide column and a synchronous belt transmission unit, which is used to drive the swing arm to lift;

[0015] The swing arm shaft is a swing arm shaft with a spline; the lower end of the swing arm shaft is arranged in the lower bearing seat; the upper end of the swing arm shaft is connected to the swing arm, and the middle part of the swing arm shaft is inserted into the spline bearing seat on the swing arm bracket support plate; the swing arm bracket support plate is fixed on the base;

[0016] The electric gripper is arranged at the end of the swing arm.

[0017] The flipping injection port mechanism comprises a fourth motor and a tip flipping block capable of accommodating the tip. The fourth motor and the tip flipping block are both arranged on a flipping mechanism fixing plate fixed on the base.

[0018] The high voltage electricity applying mechanism includes a high voltage electrical connector, a conductive spring and an insulating block;

[0019] The high-voltage power application mechanism is arranged at the flip injection port mechanism; the high-voltage electrical connector is fixed on the high-voltage connector fixing plate on the base, and the high-voltage electrical connector is connected to the conductive spring piece through a wire; the insulating block is arranged on the flip mechanism fixing plate of the flip injection port mechanism; the conductive spring piece is fixed on the insulating block.

[0020] Beneficial effects:

[0021] The ionization injection platform device for a mass spectrometer of the utility model has the following characteristics:

[0022] 1. Except for the manual handling of the tip and its placement on the sample rack, the entire testing process is completed automatically by the mechanism, which greatly saves manual operation procedures and time costs.

[0023] 2. The instrument has higher intelligence and accuracy than manual operation, effectively avoiding errors that may be caused by manual operation.

[0024] 3. Applying high voltage electricity is safe and convenient, avoiding the possible risk of discharge.

[0025] In summary, the ionization sampling platform device of the present invention has a compact structure, a high degree of automation, and high detection efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the overall structure of an ionization injection platform device for a mass spectrometer;

[0027] Figure 2 1 is a schematic structural diagram of a rotating sample rack (top view);

[0028] Figure 3 1 is a schematic structural diagram of a rotating sample rack (stereoscopic diagram);

[0029] Figure 4 2 is a schematic structural diagram of a rotating sample rack (front view);

[0030] Figure 5 It is a structural diagram of the swing arm grasping mechanism;

[0031] Figure 6 1 is a schematic structural diagram of a flip injection port mechanism;

[0032] Figure 7 It is a structural schematic diagram of the high voltage power application mechanism.

[0033] Explanation of the reference numbers: 1-base, 2-rotating sample holder, 3-swing arm grabbing mechanism, 4-flipping injection port mechanism, 5-high voltage application mechanism;

[0034] 21-disc, 22-first motor; 23-suction head;

[0035] 31 - swing arm, 32 - swing arm bracket support plate, 33 - swing arm shaft, 34 - electric gripper, 35 - second motor, 36 - third motor; 37 - Z-axis support plate, 38 - lower side bearing seat; 39 - spline bearing seat;

[0036] 41 - the third motor, 42 - the suction head flip block; 43 - the flip mechanism fixing plate;

[0037] 51 - high voltage connector fixing plate, 52 - high voltage electrical connector, 53 - conductive spring, 54 - insulating block. DETAILED DESCRIPTION

[0038] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments:

[0039] Example 1: Figure 1-7 This utility model provides an ionization injection platform device for a mass spectrometer. It is a new type of automatic injection ionization platform for ionization experiments, mainly used to facilitate experimenters to better conduct ionization experiments. The ionization platform mainly consists of a rotating sample holder, a swing arm grasping mechanism, a flip injection port mechanism, and a high-voltage application mechanism.

[0040] As shown in Figures 2 - 7, the rotating sample rack includes a sample rack and a synchronous belt drive mechanism below it. The stepping motor, i.e., the first motor 22, drives the upper sample rack (i.e., the disk 21) to rotate to the specified grasping station through the synchronous belt drive. The grasping stations are mainly divided into an inner - ring grasping station and an outer - ring grasping station. The swing - arm grasping mechanism mainly consists of a swing arm 31 with a spline (also known as a spline swing arm) and an electric gripper 34. The swing arm can achieve up - and - down movement and rotational movement along the z - axis driven by the third motor. The gripper is fixed on the upper swing arm, and through the movement of the spline swing arm to the grasping and placing positions, the picking and placing of the sample to be measured are realized. The flipping sampling - port mechanism mainly consists of a support plate (i.e., the flipping - mechanism fixing plate 43), a suction - tip flipping block 42, and a flipping motor (i.e., the fourth motor 41). The high - voltage application mechanism mainly includes components such as a high - voltage terminal 52, a high - voltage wire, and a conductive elastic sheet 53.

[0041] The following is a detailed description with reference to the drawings:

[0042] Figure 2 The component shown is a rotating sample rack. The upper and lower plates of the sample rack are connected by threaded columns. The sample rack is used to place the samples to be measured. Here, the sample specifically refers to the processed tip head. The tip of the tip head is placed downward on the sample rack. The placement positions on the sample rack are divided into an inner ring and an outer ring, and the placement quantities are 18 and 8 respectively. The sample rack is connected to the lower synchronous pulley through a rotating bearing seat. The rotating bearing seat is fixed on the support plate that serves as the entire component. The synchronous pulley is connected by a synchronous belt and is driven by the left - hand drive motor to rotate the sample rack to the specified station, thus facilitating the gripper to grasp the tip head.

[0043] As Figure 3 -5, the z - axis support plate 37 is fixed on the side of the bottom plate (i.e., the base 1). The swing - arm support plate is vertically assembled on the z - axis support plate. The spline bearing seat of the swing arm is fixed in the circular groove at the front end of the swing - arm support plate. A synchronous pulley is assembled below the bearing seat, and the rotation function is achieved through the synchronous - belt pulley drive driven by the right - hand motor. Due to the nature of the spline itself, the spline shaft can move up and down in the spline seat to achieve the up - and - down movement function along the z - axis. The bearing seat below the spline shaft is connected to the z - axis belt, and the motor - driven belt can drive the entire spline shaft to move up and down. The upper end of the spline shaft is assembled with a gripper - fixing crossbeam. The length of the crossbeam is the radius of the rotational movement of the swing arm. The gripper is fixed at the end of the crossbeam. The gripper is designed like a pair of scissors and is driven up and down by a small motor above to open or clamp the lower jaws, realizing the function of grasping and placing the tip head.

[0044] Figure 6The component shown is the flipping sampling port mechanism. The support plate of the flipping mechanism is directly fixed on the instrument base plate. The flipping block is directly fixed on the stepping motor shaft. The rotation of the motor drives the flipping block to make a rotational movement. The motor fixing plate is assembled at the rear side of the support plate. The mounting holes of the motor fixing plate are oblong holes, which facilitate the horizontal adjustment of the positions of the motor and the flipping block. When the tip is grabbed by the gripper from the sample rack to the flipping position, the motor drives the tip in the flipping block to move to the horizontal position. At this time, the tip of the tip is concentric with the tip of the mass spectrometer detection port.

[0045] Figure 7 The component shown is the high-voltage application mechanism. The high-voltage connector is fixed on the right side of the base plate. There is a high-voltage wire connecting the high-voltage connector to the conductive elastic sheet. The conductive elastic sheet is fixed on the insulating block. The conductive elastic sheet is cut from a thin stainless steel strip with good elasticity and processed into an arc shape. When the tip moves to the horizontal position, the conductive elastic sheet is lifted by the tip. Due to the good elasticity of the conductive elastic sheet, it can be in close contact with the tip of the tip without affecting the levelness of the tip. At this time, when the high voltage is turned on, the high voltage can be released to the tip of the tip. The sample at the tip of the tip enters the sampling port of the mass spectrometer after ionization, and the instrument outputs the detection result. After the detection is completed, the flipping block rotates the tip to the vertical direction, and it is grabbed by the gripper and enters the waste area through the waste tip pipeline.

[0046] Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. An ionization injection platform device for a mass spectrometer, characterized in that, It includes a base and a rotating sample rack, a swing arm grasping mechanism, a flipping sampling port mechanism, and a high-voltage application mechanism arranged on the base; The rotating sample rack is used to load multiple samples to be tested; the samples to be tested are placed in pipette tips; The swing arm grasping mechanism is used to pick up and place the samples to be tested through the lifting and rotating actions of the electric gripper; The flipping sampling port mechanism is arranged at the detection port of the mass spectrometer and is used to control the flipping action of the sample to be tested so that the sample to be tested is aligned with the tip of the detection port of the mass spectrometer; The high-voltage application mechanism is used to release high voltage to the tip of the pipette tip.

2. The ionization injection platform device for a mass spectrometer according to claim 1, characterized in that, The rotating sample rack includes a driving mechanism and a disc; the disc has an outer ring and an inner ring placement position; the driving mechanism drives the disc to rotate through a first motor and a synchronous belt drive unit.

3. The ionization injection platform device for a mass spectrometer according to claim 1, characterized in that, The swing arm grasping mechanism includes a swing arm, a swing arm support plate, a swing arm rotating shaft, a swing arm rotation driving mechanism, a swing arm lifting driving mechanism, and an electric gripper; The swing arm rotation driving mechanism includes a second motor and a synchronous belt drive unit for driving the swing arm to rotate; The swing arm lifting driving mechanism includes a third motor, a Z-axis guide post, and a synchronous belt drive unit for driving the swing arm to lift; the swing arm rotating shaft is a splined swing arm rotating shaft; the lower end of the swing arm rotating shaft is arranged in the lower bearing seat; the upper end of the swing arm rotating shaft is connected to the swing arm, and the middle part of the swing arm rotating shaft is inserted into the spline bearing seat on the swing arm support plate; the swing arm support plate is fixed on the base; The electric gripper is arranged at the end of the swing arm.

4. The ionization injection platform device for a mass spectrometer according to claim 1, characterized in that, The flipping sampling port mechanism includes a fourth motor and a pipette tip flipping block capable of accommodating the pipette tip, and both the fourth motor and the pipette tip flipping block are arranged on the flipping mechanism fixing plate fixed on the base.

5. The ionization injection platform device for a mass spectrometer according to any one of claims 1-4, characterized in that, The high-voltage application mechanism includes a high-voltage connector, a conductive elastic sheet, and an insulating block; The high-voltage application mechanism is arranged at the flipping sampling port mechanism; the high-voltage connector is fixed on the high-voltage connector fixing plate on the base, and the high-voltage connector is connected to the conductive elastic sheet through a wire; the insulating block is arranged on the flipping mechanism fixing plate of the flipping sampling port mechanism; the conductive elastic sheet is fixed on the insulating block.

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