Screw racking machine capable of cleaning and sterilizing on line

Abstract

The utility model discloses a screw racking machine capable of cleaning and sterilizing on line. The screw racking machine comprises a buffer tank mechanism, a powder feeding mechanism and a racking mechanism which are arranged on a supporting mechanism and are communicated in sequence, wherein a top tank opening of the buffer tank mechanism and a bottom discharging opening of the subpackaging mechanism are connected with a CIPSIP station through quick couplers respectively to form an online cleaning and online sterilization channel. According to the utility model, all that is needed is to connect the pipelines, the operation is automatically carried out according to a set process, and the CIPSIP operation is simple; all operations included in offline sterilization can be reduced, the time occupied by production is prolonged, and the operation time of cleaning and sterilization is greatly saved.

Description

Technical Field

[0001] The utility model relates to a screw filling machine, in particular to a screw filling machine capable of online cleaning and sterilization. Background Art

[0002] As a traditional filling device, the screw filling machine has been used until now due to its irreplaceable advantages (large filling range, low cost, and simple structure). The screw filling principle is to use the intermittent rotation of the screw. According to the metering requirements, by controlling the rotation speed of the screw, the drug powder is quantitatively filled into the vial. Its working process is roughly as follows: The sterile powder is loaded into the hopper, the screw in the filling head rotates, and the screw conveys the internal powder drug along the axis direction to the outlet of the filling mechanism, and then falls into the vial below the filling head.

[0003] After the screw filling machine completes a day's work, the components that directly or indirectly contact the drug powder, such as the filling screw, powder viewing cover, and funnel, need to be cleaned and sterilized for the next day's production. Due to the current technical deficiencies, this process can only be achieved by manual operation, that is, the so-called off-line sterilization and aseptic transfer. Off-line sterilization requires manual disassembly of components for cleaning, then placing them in the sterilization cabinet for a period of high-temperature sterilization, and after sterilization, they are aseptically transferred to the equipment and then manually aseptically installed. This off-line sterilization operation process is time-consuming and laborious, and the risk is very high. Summary of the Utility Model

[0004] The utility model provides a screw filling machine capable of online cleaning and sterilization to solve the technical problem that the traditional filling machine needs off-line sterilization. The new filling machine realizes the functions of online cleaning and online sterilization for the components in contact with the drug powder through a clever structure.

[0005] To achieve the above object, the utility model adopts the following technical solutions:

[0006] A screw filling machine capable of online cleaning and sterilization, comprising a buffer tank mechanism, a powder feeding mechanism, and a filling mechanism that are installed on a support mechanism and are connected in sequence; wherein, the top tank opening of the buffer tank mechanism and the bottom discharge port of the filling mechanism are respectively connected to an online cleaning and sterilization station through quick connectors to form an online cleaning and online sterilization path.

[0007] Preferably, the support mechanism includes a support shaft seat, a support large plate, and a support upper plate, wherein:

[0008] The support shaft seat is a columnar structure arranged vertically, and its upper end is rotatably connected to the middle of the support large plate through a bearing;

[0009] The support large plate is in a Z-shaped structure, and the buffer tank mechanism and the powder feeding mechanism are inclinedly installed at its lower end, and the driving component of the sub-packaging mechanism is installed at its higher end;

[0010] The support upper plate covers the higher end of the support large plate, and the motor housing of the sub-packaging mechanism is installed at its end.

[0011] Preferably, the buffer tank mechanism includes a buffer barrel, a buffer stirring paddle and a buffer driving component, wherein:

[0012] The lower end of the buffer barrel is detachably installed on the chuck seat of the powder feeding mechanism by a first clamp, and the buffer stirring paddle is vertically arranged therein;

[0013] The power shaft of the buffer driving component is hermetically connected to the inner hole of the chuck seat by a first special-shaped sealing ring, and is detachably connected to the lower end of the buffer stirring paddle.

[0014] More preferably, a buffer tank heat preservation interlayer is arranged outside the buffer barrel, a first liquid discharge joint is arranged at the lower end of the buffer tank heat preservation interlayer, and a first liquid inlet joint is arranged at the upper end;

[0015] A powder stirring flange is coaxially sleeved outside the power shaft of the buffer driving component, and the upper and lower ends of the powder stirring flange are respectively detachably connected to the top of the buffer driving component and the bottom of the chuck seat.

[0016] Preferably, the powder feeding mechanism includes a chuck seat, a powder feeding driving component, a powder feeding flange, a powder feeding pipe and a powder feeding screw, wherein:

[0017] A first installation hole is vertically opened in the middle of the chuck seat, a second installation hole inclined downward towards the sub-packaging mechanism is horizontally opened at one side end, and a buffer bottom groove connecting the first installation hole and the second installation hole is arranged at the top;

[0018] The powder feeding driving component is fixedly installed at one end of the chuck seat through the powder feeding flange, and a second special-shaped sealing ring is arranged between it and the powder feeding flange;

[0019] The powder feeding flange is coaxially sleeved outside the power shaft of the powder feeding driving component, and a first sealing ring is arranged between it and the chuck seat;

[0020] The powder feeding pipe is inclinedly arranged, a second sealing ring is arranged between one end of it and the outlet of the second installation hole, a third sealing ring is arranged between the other end and the sub-packaging mechanism, and a powder feeding heat preservation interlayer is arranged on the outer periphery of the powder feeding pipe;

[0021] The powder feeding screw is arranged in the second mounting hole and the powder feeding pipe which are coaxially arranged. Its front end is shaft-connected to the power shaft of the powder feeding driving component, and its rear end extends to the feeding port above the sub-packaging mechanism.

[0022] Preferably, the second mounting hole, the powder feeding pipe and the powder feeding screw in the chuck base are coaxially arranged and inclined downward, and the inclination angle relative to the horizontal plane is 3-10°.

[0023] Preferably, the bottom of the chuck base is a plane and the top is an inclined plane. The sub-packaging mechanism is vertically installed on its top, and the inclination angle of its top inclined plane is 3-10°.

[0024] Preferably, the sub-packaging mechanism includes a feeding cylinder, a middle material cylinder, a discharging cylinder, a screw sleeve, a sub-packaging screw and a sub-packaging driving component which are coaxially arranged, where:

[0025] The feeding cylinder, the middle material cylinder and the discharging cylinder are detachably connected in sequence from top to bottom. The top end of the feeding cylinder is fixedly installed at the bottom of the higher end of the supporting plate of the supporting mechanism, and an opening communicating with the powder feeding pipe is arranged on its side wall;

[0026] The upper end of the screw sleeve is shaft-connected to the power shaft of the sub-packaging driving component installed on the supporting plate, and its lower end is fixedly connected to the upper end of the sub-packaging screw located in the discharging cylinder;

[0027] The sub-packaging driving component is installed downward on the bearing seat through a powder feeding flange sleeved outside its power shaft, and the lower end of the bearing seat is fixedly installed in the through hole at the end of the supporting plate through a seat sleeve.

[0028] Preferably, the sub-packaging mechanism further includes a sub-packaging stirring paddle, a sub-packaging stirring shaft, a sub-packaging sleeve, a secondary stirring gear, a main stirring gear and a stirring driving component, where:

[0029] There is at least one sub-packaging stirring paddle, which is located outside the screw sleeve and / or the sub-packaging screw, and is fixedly connected to the lower end of the sub-packaging stirring shaft, and at least one sub-packaging stirring paddle extends downward to one side of the sub-packaging screw;

[0030] The inner cavity of the sub-packaging stirring shaft is coaxially provided with the screw sleeve, and its lower end inner wall and the screw sleeve are sealed and connected through a needle roller bearing and a third special-shaped sealing ring;

[0031] The lower end of the sub-packaging sleeve is connected to the upper end of the sub-packaging stirring shaft, and the outer wall of its upper end and the inner wall of the upper end of the feeding cylinder are sealed and connected through a fourth special-shaped sealing ring, and the top end is connected to the secondary stirring gear;

[0032] The auxiliary stirring gear is rotatably installed at the lower end of the bearing seat through a bearing, and is connected to the power shaft of the stirring drive component through the main stirring gear arranged on one side.

[0033] Preferably, the sub-packaging mechanism further includes a pressure balance hose and a diaphragm valve, wherein:

[0034] The lower end of the pressure balance hose is connected to the inner cavity of the lower end of the blanking cylinder through a first quick connector, the upper end is connected to the inner cavity of the feeding cylinder through a second quick connector, and the diaphragm valve is installed thereon.

[0035] Adopting the above technical solutions, the utility model has the following technical effects compared with the prior art:

[0036] The screw filling machine of the utility model that can be cleaned and sterilized online only needs to connect the pipelines well and automatically carry out according to the set process, and the CIPSIP operation is simple; it can reduce all operations included in off-line sterilization, increase the time occupied by production, and greatly save the operation time of cleaning and sterilization; moreover, the improved screw filling machine can better implement the aseptic operation process and reduce the risks brought by off-line sterilization. Description of the Drawings

[0037] Figure 1 is a schematic three-dimensional structure diagram of a screw filling machine of the utility model that can be cleaned and sterilized online Figure 1 ;

[0038] Figure 2 is a schematic three-dimensional structure diagram of a screw filling machine of the utility model that can be cleaned and sterilized online Figure 2 ;

[0039] Figure 3 is a schematic side view structure diagram of a screw filling machine of the utility model that can be cleaned and sterilized online;

[0040] Figure 4 is a schematic front view structure diagram of a screw filling machine of the utility model that can be cleaned and sterilized online;

[0041] Figure 5 is a schematic horizontal cross-sectional structure diagram of a screw filling machine of the utility model that can be cleaned and sterilized online;

[0042] Figure 6 is a schematic enlarged partial structure diagram of part A in a screw filling machine of the utility model that can be cleaned and sterilized online;

[0043] Figure 7 is a schematic enlarged partial structure diagram of part B in a screw filling machine of the utility model that can be cleaned and sterilized online;

[0044] Figure 8Schematic diagram of the partial enlarged structure of part C in a screw powder filling machine with online cleaning and sterilization function according to the present utility model;

[0045] Figure 9 Schematic diagram of the longitudinal sectional structure at the A-A position in a screw powder filling machine with online cleaning and sterilization function according to the present utility model;

[0046] Figure 10 Schematic diagram of the partial enlarged structure of part D in a screw powder filling machine with online cleaning and sterilization function according to the present utility model;

[0047] Figure 11 Schematic diagram of the partial side sectional structure of a screw powder filling with CIP and SIP functions according to the present utility model;

[0048] Figure 12 Schematic diagram of the process flow of a screw powder filling with CIP and SIP functions according to the present utility model. Detailed implementation manners

[0049] The present utility model will be introduced in detail and specifically through specific embodiments below to better understand the present utility model. However, the following embodiments do not limit the scope of the present utility model.

[0050] In some embodiments, as Figure 1 , Figure 2 , Figure 3 and Figure 4 shown, a screw powder filling machine with online cleaning and sterilization function is provided. The screw powder filling machine mainly includes a support mechanism 100, a buffer tank mechanism 200, a powder feeding mechanism 300, a powder filling mechanism 400 installed at the left and right ends of the support mechanism 100, and a supporting online cleaning and sterilization station 500. The front and rear ends of the powder feeding mechanism 300 are respectively communicated with the buffer tank mechanism 200 and the powder filling mechanism 400 to form a powder feeding path. The online cleaning and sterilization station 500 is respectively communicated with the top tank opening of the buffer tank mechanism 200 and the bottom discharge port of the powder filling mechanism 400 through quick connectors to form an online cleaning and online sterilization path, which is mainly used to realize CIP and SIP functions after being connected to the equipment through pipelines.

[0051] The online cleaning and sterilization station, namely the CIP / SIP station, is a CIP (Clean In Place, online cleaning) / SIP (Sanitizing In Place, online sterilization) device commonly used in the pharmaceutical production industry. CIP and SIP devices are used to clean and disinfect equipment during the production process. CIP and SIP devices are widely used in food enterprises with a high degree of mechanization such as beverages, liquid milk, and yogurt, as well as in the pharmaceutical industry.

[0052] To solve the technical problem that traditional powder filling machines require off-line sterilization, the improved screw powder filling machine achieves the functions of on-line cleaning and on-line sterilization for the components in contact with the powder through a clever structure. The specific solution is that special-shaped sealing rings that can be hermetically isolated from the powder delivery path are installed on the power shafts of the driving components in the buffer tank mechanism 200, the powder feeding mechanism 300, and the powder filling mechanism 400, and the special-shaped sealing rings are made of modified PTFE material.

[0053] During CIPSIP operation, the top tank opening of the buffer tank mechanism 200 and the bottom discharge port of the powder filling mechanism 400 are respectively connected to the on-line cleaning and sterilization station through quick connectors by manual operation, and then cleaning and sterilization are carried out. The whole process is strictly carried out in accordance with GMP. After completion, the connecting pipes are removed, and this process is carried out under the protection of Class A laminar flow. The setting of the special-shaped sealing ring can effectively separate the raw material powder from the inside of various drives, thus ensuring the safety and sterility of drug production; at the same time, it can also effectively isolate the cleaning medium, steam, etc. from the inside of the drive.

[0054] In some of the embodiments, such as Figure 1 、 Figure 2 、 Figure 3 、 Figure 4 and Figure 5 shown, the support mechanism 100 serves as the installation platform of the new screw powder filling machine, and it is mainly assembled integrally by a support shaft seat 101, a support large plate 102, and a support upper plate 103. According to requirements, the support shaft seat 101, the support large plate 102, and the support upper plate 103 are made of stainless steel or aluminum alloy.

[0055] Specifically, the support shaft seat 101 is a columnar structure arranged vertically. The upper end thereof is rotatably connected to the middle part of the support large plate 102 through a bearing, and the lower end is detachably installed on the equipment platform by bolts. The rotation of the support large plate 102 on the support shaft seat 101 can be flexibly controlled through the bearing, so as to realize the adjustment of the powder filling mechanism 400 in different angular directions, and then meet the purpose of multi-station powder filling.

[0056] To facilitate the installation of the buffer tank mechanism 200, the powder feeding mechanism 300, and the powder filling mechanism 400, the support large plate 102 is designed as an overall Z-shaped structure. The buffer tank mechanism 200 and the powder feeding mechanism 300 are inclinedly installed at its lower end, and the driving components of the powder filling mechanism 400 are installed at its higher end. The powder in the buffer tank mechanism 200 is transported from a high position to the powder filling mechanism 400 located at a low position.

[0057] In addition, the support upper plate 103 is detachably covered on the higher end of the support large plate 102 by a plurality of screws to form a power accommodating space between the support large plate 102 and the support upper plate 103, and the main power components of the powder filling mechanism 400 are installed in this power accommodating space.

[0058] Moreover, in order to avoid the driving component at the top of the powder dispensing mechanism 400, a mounting hole is provided at the outer end of the supporting upper plate 103, and the motor housing 422 of the powder dispensing mechanism 400 is installed in the mounting hole to realize the installation and fixation of the motor housing 422.

[0059] In some of the embodiments, such as Figure 5 , Figure 9 and Figure 10 shown, the buffer tank mechanism 200 mainly includes a buffer barrel 201, a buffer stirring paddle 202 and a buffer driving component 203. The buffer barrel 201 is a hollow cylindrical structure with openings at both the upper and lower ends, and quick connectors are provided at both the upper and lower ends thereof, and is coaxially arranged with the buffer stirring paddle 202 therein.

[0060] The lower opening of the buffer barrel 201 is in a reduced shape, and it is detachably installed on the chuck seat 301 of the powder feeding mechanism 300 by a first clamp 206, and a sealing ring is provided at the connection between the two. Moreover, the buffer stirring paddle 202 vertically arranged in its inner cavity is shaft-connected to the power shaft of the buffer driving component 203 below. The buffer driving component 203 adopts a servo motor, and by starting the buffer driving component 203, the buffer stirring paddle 202 can be synchronously driven to rotate, thereby achieving the purpose of stirring and discharging the powder in the buffer barrel 201.

[0061] In order to effectively separate the raw material powder in the buffer barrel 201 from the buffer driving component 203 below, a first special-shaped sealing ring 205 is respectively used at the upper and lower ends of the power shaft of the buffer driving component 203 to be hermetically connected to the inner hole of the chuck seat 301 and the motor housing, so as to prevent the powder from entering the buffer driving component 203 from the buffer barrel 201, thereby ensuring the safety and sterility of drug production. At the same time, when performing the CIPSIP function, the setting of the first special-shaped sealing ring 205 can also effectively isolate the cleaning medium and steam from the inside of the drive.

[0062] As a preferred embodiment, as Figure 5 and Figure 9 shown, in order to ensure the stability of the high-temperature steam temperature during CIPSIP operation, a buffer tank heat preservation interlayer 207 is provided outside the buffer barrel 201. A first drain joint 208 is provided at the lower end of the buffer tank heat preservation interlayer 207, and a first liquid inlet joint 209 is provided at the upper end. High-temperature circulating water is passed through the buffer tank heat preservation interlayer 207 through the first drain joint 208 and the first liquid inlet joint 209 to prevent the heat of the high-temperature steam from dissipating.

[0063] To install and fix the buffer driving component 203, a powder stirring flange 204 is coaxially sleeved outside the power shaft of the buffer driving component 203, and the upper and lower ends of the powder stirring flange 204 are respectively detachably connected to the top of the buffer driving component 203 and the bottom of the chuck seat 301.

[0064] When the buffer tank mechanism 200 is in use, the bagged raw material powder is poured into the buffer hopper 201 under the protection of the Class A laminar flow until the appropriate powder level is reached. The buffer tank mechanism 200 is equipped with a minimum powder level detection sensor 210. When the powder level reaches the lowest position, the control system will prompt the feeding operation. The buffer stirring paddle 202 in the buffer hopper 201 rotates slowly to assist in powder feeding, and the stirring speed is adjustable according to the characteristics of the powder.

[0065] In some of the embodiments, such as Figure 5 , Figure 6 , Figure 9 and Figure 10 shown, the powder feeding mechanism 300 mainly includes a chuck seat 301, a powder feeding driving component 302, a powder feeding flange 303, a powder feeding pipe 304 and a powder feeding screw 305. The powder feeding driving component 302 slowly pushes the raw material powder forward through the powder feeding screw 305 into the powder cup of the sub-packaging mechanism 400, and its purpose is to transport the raw medicine in the buffer tank mechanism 200 to the sub-packaging mechanism 400 for sub-packaging.

[0066] Specifically, to facilitate the installation of the buffer tank mechanism 200 and the powder feeding mechanism 300, a chuck seat 301 with a specific structural design is adopted. A first installation hole 3011 is vertically opened in the middle of the chuck seat 301 for installing the power shaft on the buffer tank mechanism 200. A second installation hole 3032 is horizontally opened on the chuck seat 301 on one side of the first installation hole 3011 and is arranged obliquely downward towards the sub-packaging mechanism 400 for installing the power shaft of the powder feeding driving component 302, that is, the powder feeding screw 305.

[0067] At the same time, to facilitate the installation of the buffer hopper 201, a buffer bottom groove 3013 connecting the first installation hole 3011 and the second installation hole 3012 is provided at the top of the chuck seat 301, that is, the first installation hole 3011 and the second installation hole 3012 are located at the bottom of the buffer bottom groove 3013, facilitating the installation of the buffer driving component 203 and the powder feeding screw 305.

[0068] A second special-shaped sealing ring 306 is provided between the powder feeding driving component 302 and the powder feeding flange 303. The second special-shaped sealing ring 306 is made of modified PTFE material and is used to separate the raw material powder in the buffer barrel 201 from the powder feeding driving component 302 on one side, preventing the medicinal powder from entering the powder feeding driving component 302 from the buffer barrel 201, thereby ensuring the safety and sterility of drug production. At the same time, when performing the CIPSIP function, the setting of the second special-shaped sealing ring 306 can also effectively isolate the cleaning medium, steam, etc. from the inside of the powder feeding driving component 302, thus ensuring the stable operation of the powder feeding driving component 302.

[0069] For the quick installation and fixation of the powder feeding driving component 302, the powder feeding driving component 302 is fixedly installed at one end of the chuck seat 301 through the powder feeding flange 303, and the powder feeding flange 303 is coaxially sleeved outside the power shaft of the powder feeding driving component 302, and a first sealing ring 307 is provided between it and the chuck seat 301. The first sealing ring 307 is made of modified PTFE material.

[0070] To improve the powder feeding efficiency, the powder feeding pipe 304 and the powder feeding screw 305 arranged therein are inclined. A second sealing ring 308 is provided between one end of the powder feeding pipe 304 and the outlet of the second installation hole 3012, and a third sealing ring 309 is provided between the other end of the powder feeding pipe 304 and the sub-packaging mechanism 400.

[0071] At the same time, to ensure the stability of the high-temperature steam temperature during CIPSIP operation, a powder feeding heat preservation interlayer 310 is provided on the outer periphery of the powder feeding pipe 304; a second liquid discharge joint 311 is provided at the lower end of the powder feeding heat preservation interlayer 310, and a second liquid inlet joint 312 is provided at the higher end thereof. High-temperature circulating water is passed through the powder feeding heat preservation interlayer 310 through the second liquid discharge joint 311 and the second liquid inlet joint 312 to prevent the heat dissipation of the high-temperature steam.

[0072] From Figure 5 and Figure 7 it can be seen that the powder feeding screw 305 is arranged in the coaxially arranged second installation hole 3032 and powder feeding pipe 304. Its front end is axially connected to the power shaft of the powder feeding driving component 302, and the rear end extends to the feed port above the sub-packaging mechanism 400. The powder feeding driving component 302 can synchronously drive the powder feeding screw 305 serving as the power shaft to rotate, so as to convey the raw material powder in the buffer barrel 201 to the downstream sub-packaging mechanism 400 through the powder feeding pipe 304, realizing the feeding of the raw material powder.

[0073] In addition, as some of the preferred embodiments, the second mounting hole 3012, the powder feeding pipe 304 and the powder feeding screw 305 in the chuck base 301 are coaxially arranged and inclined downward, and the inclination angle relative to the horizontal plane is 3-10°, preferably 4°. Correspondingly, the chuck base 301 adopts an inclined block structure, the bottom of which is a plane and the top is an inclined surface. The dispensing mechanism 400 is vertically installed on the top of the chuck base 301, and the inclination angle of the inclined surface at the top of the chuck base 301 is 3-10°, preferably 4°.

[0074] In some of the embodiments, such as Figure 2 , Figure 5 , Figure 7 , Figure 8 and Figure 10 shown, the dispensing mechanism 400 mainly includes a feeding cylinder 401, a middle material cylinder 402, a discharging cylinder 403, a screw sleeve 404, a dispensing screw 405 and a dispensing driving component 414 which are coaxially arranged. A powder level sensor 413 is installed on the material cylinder at the lower part of the dispensing mechanism 400. When it is detected that the powder level reaches the lowest level, the control system will make the powder feeding screw 305 rotate to realize the function of automatic feeding.

[0075] The feeding cylinder 401, the middle material cylinder 402 and the discharging cylinder 403 are detachably connected together by a clamp from top to bottom, and they are all made of stainless steel or aluminum alloy. The top end of the feeding cylinder 401 is fixedly installed at the bottom of the higher end of the support plate 102 of the support mechanism 100, and a side opening communicating with the powder feeding pipe 304 is provided on the side wall of the feeding cylinder 401.

[0076] To realize the transmission connection between the dispensing driving component 414 and the lower dispensing screw 405, a screw sleeve 404 is arranged between them. The upper end of the screw sleeve 404 is axially connected to the power shaft of the dispensing driving component 414 installed on the support plate 102, and the lower end of the screw sleeve 404 is fixedly connected to the upper end of the dispensing screw 405 located in the discharging cylinder 403. When the dispensing driving component 414 is started, the lower dispensing screw 405 can be synchronously driven to rotate through the screw sleeve 404, and then the purpose of discharging and dispensing is realized.

[0077] In addition, to facilitate the installation and fixation of the dispensing driving component 414, the dispensing driving component 414 is installed downward on the bearing seat 416 through a powder feeding flange 415 sleeved on the outside of its power shaft, and the lower end of the bearing seat 416 is fixedly installed in the through hole at the end of the support plate 102 through a seat sleeve 417.

[0078] In some of the embodiments, to improve the dispensing efficiency, such as Figure 5 , Figure 7 and Figure 8As shown, the sub-packaging mechanism 400 further includes a stirring and mixing mechanism composed of a sub-packaging stirring paddle 406, a sub-packaging stirring shaft 407, a sub-packaging sleeve 410, a secondary stirring gear 419, a main stirring gear 420, and a stirring drive component 421. The stirring and mixing mechanism is used to stir the powder during the sub-packaging process to accelerate the feeding speed.

[0079] There is at least one sub-packaging stirring paddle 406, which is located outside the screw adapter 404 and / or the sub-packaging screw 405, and is fixedly connected to the lower end of the sub-packaging stirring shaft 407. The sub-packaging stirring paddle 406 is synchronously driven by the sub-packaging stirring shaft 407 to perform stirring. As Figure 5 and Figure 8 shown, there are two sub-packaging stirring paddles 406, which are arranged facing and upward respectively.

[0080] According to needs, one of the sub-packaging stirring paddles 406 extends downward to a position on one side of the sub-packaging screw 405 to stir and mix the powder outside the sub-packaging screw 405, thereby accelerating the sub-packaging efficiency of the sub-packaging screw 405. As Figure 5 and Figure 8 shown, the downwardly arranged sub-packaging stirring paddle 406 adopts a specific structural design. Its upper end is in a vertically arranged Z-shaped structure, the lower end is provided with a semi-circular spiral blade plate, and a number of stirring bars are arranged at intervals at the bottom of the blade plate to improve the feeding rate.

[0081] In addition, the screw adapter 404 is coaxially arranged in the inner cavity of the sub-packaging stirring shaft 407, and the inner wall of its lower end is hermetically connected to the screw adapter 404 through a needle roller bearing 408 and a third special-shaped sealing ring 409. The third special-shaped sealing ring 409 is made of modified PTFE material, which is used to separate the raw material powder in the sub-packaging mechanism 400 from the upper sub-packaging drive component 414, and prevent the powder from entering the sub-packaging drive component 414, so as to ensure the safety and sterility of drug production. At the same time, when the CIPSIP function is executed, the setting of the third special-shaped sealing ring 409 can also effectively isolate the cleaning medium and steam from the inside of the sub-packaging drive component 414, so as to ensure the stable operation of the sub-packaging drive component 414.

[0082] Similarly, the lower end of the dispensing sleeve 410 is connected to the upper end of the dispensing and stirring shaft 407, and the outer wall of its upper end is hermetically connected to the inner wall of the upper end of the feeding cylinder 401 through a fourth special-shaped sealing ring 418. The fourth special-shaped sealing ring 418 is made of modified PTFE material and is used to separate the raw material powder in the dispensing mechanism 400 from the upper dispensing drive component 414 and the stirring drive component 421, preventing the medicine powder from entering the dispensing drive component 414 and the stirring drive component 421 from the dispensing drive component 414, thus ensuring the safety and sterility of drug production. At the same time, when performing the CIPSIP function, the setting of the fourth special-shaped sealing ring 418 can also effectively isolate the cleaning medium, steam, etc. from the inside of the dispensing drive component 414, thus ensuring the stable operation of the dispensing drive component 414 and the stirring drive component 421.

[0083] The transmission of the stirring and mixing mechanism is as follows. The secondary stirring gear 419 is rotatably installed at the lower end of the bearing seat 416 through a bearing, and its power shaft of the stirring drive component 421 is connected through the main stirring gear 420 provided on one side. When the stirring drive component 421 is started, through the meshing between the main stirring gear 420 and the secondary stirring gear 419, the dispensing stirring paddle 406 can be synchronously driven to stir through the dispensing sleeve 410 and the dispensing and stirring shaft 407.

[0084] In some of the embodiments, since the powder storage space in the lower cavity of the entire dispensing mechanism 400 is airtight, as the powder becomes less and less, the internal pressure will decrease, which affects the smooth dispensing of the medicine powder. Therefore, to solve this problem and balance the pressure difference between the cavity where the material is located and the external environment, as Figure 1 , Figure 3 , Figure 4 and Figure 11 shown, a pressure balance hose 423 is provided as a bypass pipe on one side of the lower cavity of the dispensing mechanism 400.

[0085] Specifically, the lower end of the pressure balance hose 423 is connected to the inner cavity of the lower end of the blanking cylinder 403 through a first quick-connect fitting 424, and the upper end is connected to the inner cavity of the feeding cylinder 401 through a second quick-connect fitting 425, and the diaphragm valve 426 is installed thereon to balance the internal and external pressures of the cavity.

[0086] This screw powder dispenser has the functions of online cleaning and online sterilization. Sealing rings made of modified PTFE are installed on the power shafts of the buffer tank component drive, the dispensing drive, and the powder feeding drive. These sealing rings can effectively separate the raw material powder from the inside of various drives, thus ensuring the safety and sterility of drug production. During CIPSIP operation, these sealing rings can also effectively isolate the cleaning medium, steam, etc. from the inside of the drives.

[0087] When performing the CIPSIP function, manually connect the pipelines of the on-line cleaning and sterilization station 500 to the quick-connect joints at the buffer tank mechanism 200 and the filling mechanism 400, and then carry out cleaning and sterilization. The whole process is strictly carried out in accordance with GMP. After completion, remove the connecting pipelines. This process is carried out under the protection of Class A laminar flow.

[0088] Specifically, as Figure 12 shown, the technological process of on-line cleaning and on-line sterilization of this screw filling machine capable of on-line cleaning and sterilization is as follows: After production is completed, all components in contact with materials are not disassembled. Manually connect the pipelines of the on-line cleaning and sterilization station 500 to the quick-connect joints at the buffer tank mechanism 200 and the filling mechanism 400, and then carry out the on-line cleaning and on-line sterilization procedures. The whole process is strictly carried out in accordance with GMP. After completion, remove the connecting pipelines. This process is carried out under the protection of Class A laminar flow.

[0089] The quick-connect joint with spray cleaning function connected to the L1 pipeline is compatible with connecting the L2 steam pipeline. The L6 pipeline is used to discharge waste liquid, waste gas, etc. generated during CIPSIP. When performing CIP, in order to make the cleaning more thorough, each drive motor runs synchronously to make the cleaning medium form a turbulent flow, clean all corners inside, and avoid the generation of cleaning dead corners. When performing SIP, the L1 pipeline is closed and the L2 is opened. At the same time, in order to ensure the stability of the high-temperature steam temperature of 121 degrees Celsius, high-temperature circulating water is passed through each insulation layer to prevent the heat dissipation of the high-temperature steam.

[0090] The specific embodiments of the present invention have been described in detail above, but they are only used as examples. The present invention is not limited to the specific embodiments described above. For those skilled in the art, any equivalent modifications and substitutions made to the present invention are also within the scope of the present invention. Therefore, all equivalent transformations and modifications made without departing from the spirit and scope of the present invention should be covered within the scope of the present invention.

Claims

1. A screw filling machine capable of online cleaning and sterilization, characterized in that, It includes a buffer tank mechanism, a powder feeding mechanism, and a sub-packaging mechanism that are installed on a support mechanism and are connected in sequence; among them, the top tank opening of the buffer tank mechanism and the bottom discharge port of the sub-packaging mechanism are respectively connected to an in-line cleaning and sterilization station through quick-connect joints to form an in-line cleaning and in-line sterilization path.

2. The screw powder filling machine capable of being cleaned and sterilized online according to claim 1, wherein The support mechanism includes a support shaft seat, a support large plate, and a support upper plate, where: The support shaft seat is a columnar structure arranged vertically, and its upper end is rotatably connected to the middle of the support large plate through a bearing; The support large plate is a Z-shaped structure, and the buffer tank mechanism and the powder feeding mechanism are inclinedly installed at its lower end, and the driving component of the sub-packaging mechanism is installed at its higher end; The support upper plate covers the higher end of the support large plate, and the motor housing of the sub-packaging mechanism is installed at its end.

3. The screw type powder filling machine capable of online cleaning and sterilization according to claim 1, wherein, The buffer tank mechanism includes a buffer bucket, a buffer stirring paddle, and a buffer driving component, where: The lower end of the buffer bucket is detachably installed on the chuck seat of the powder feeding mechanism by a first clamp, and the buffer stirring paddle is vertically arranged inside it; The power shaft of the buffer driving component is hermetically connected to the inner hole of the chuck seat through a first special-shaped sealing ring, and is detachably connected to the lower end of the buffer stirring paddle.

4. The screw powder filling machine capable of online cleaning and sterilization according to claim 3, wherein, A buffer tank heat preservation interlayer is arranged outside the buffer bucket, a first liquid discharge joint is arranged at the lower end of the buffer tank heat preservation interlayer, and a first liquid inlet joint is arranged at the upper end; A powder stirring flange is coaxially sleeved outside the power shaft of the buffer driving component, and the upper and lower ends of the powder stirring flange are respectively detachably connected to the top of the buffer driving component and the bottom of the chuck seat.

5. The screw powder filling machine capable of being cleaned and sterilized online according to claim 1, wherein The powder feeding mechanism includes a chuck seat, a powder feeding driving component, a powder feeding flange, a powder feeding pipe, and a powder feeding screw, where: A first installation hole is vertically opened in the middle of the chuck seat, a second installation hole inclined downward toward the sub-packaging mechanism is horizontally opened at one side end, and a buffer bottom groove connecting the first installation hole and the second installation hole is arranged at the top; The powder feeding driving component is fixedly installed at one end of the chuck seat through the powder feeding flange, and a second special-shaped sealing ring is arranged between it and the powder feeding flange; The powder feeding flange is coaxially sleeved outside the power shaft of the powder feeding driving component, and a first sealing ring is arranged between it and the chuck seat; The powder feeding pipe is arranged obliquely, a second sealing ring is arranged between one end of it and the outlet of the second installation hole, a third sealing ring is arranged between the other end and the sub-packaging mechanism, and a powder feeding heat preservation interlayer is arranged on the outer periphery of the powder feeding pipe; The powder feeding screw is arranged in the coaxially arranged second installation hole and the powder feeding pipe, its front end is axially connected to the power shaft of the powder feeding driving component, and its rear end extends to the feeding port at the upper part of the sub-packaging mechanism.

6. The screw powder filling machine capable of being cleaned and sterilized online according to claim 5, wherein The second installation hole, the powder feeding pipe, and the powder feeding screw in the chuck seat are coaxially arranged and inclined downward, and the inclination angle relative to the horizontal plane is 3-10°.

7. The screw type powder filling machine capable of online cleaning and sterilization according to claim 5, characterized in that, The bottom of the chuck seat is flat and the top is inclined, the sub-packaging mechanism is vertically installed on its top, and the inclination angle of the top inclined surface is 3-10°.

8. The screw powder filling machine capable of being cleaned and sterilized online according to claim 1, wherein, The sub-packaging mechanism includes a feeding cylinder, a middle material cylinder, a discharging cylinder, a screw connecting sleeve, a sub-packaging screw, and a sub-packaging driving component that are coaxially arranged, where: The upper feeding cylinder, the middle feeding cylinder, and the lower feeding cylinder are detachably connected in sequence from top to bottom. The top end of the upper feeding cylinder is fixedly installed at the bottom of the higher end of the support plate of the support mechanism, and an opening communicating with the powder feeding pipe is provided on its side wall; The upper end of the screw sleeve is axially connected to the power shaft of the dispensing drive component installed on the support plate, and its lower end is fixedly connected to the upper end of the dispensing screw located in the lower feeding cylinder; The dispensing drive component is installed downward on the bearing seat through the powder feeding flange sleeved outside its power shaft, and the lower end of the bearing seat is fixedly installed in the through hole at the end of the support plate through the seat sleeve.

9. The screw powder filling machine capable of being cleaned and sterilized online according to claim 8, wherein, The dispensing mechanism further includes a dispensing stirring paddle, a dispensing stirring shaft, a dispensing sleeve, a secondary stirring gear, a primary stirring gear, and a stirring drive component, where: There is at least one dispensing stirring paddle, which is located outside the screw sleeve and / or the dispensing screw, and is fixedly connected to the lower end of the dispensing stirring shaft, and at least one dispensing stirring paddle extends downward to one side of the dispensing screw; The inner cavity of the dispensing stirring shaft is coaxially provided with the screw sleeve, and the inner wall of its lower end is hermetically connected to the screw sleeve through a needle bearing and a third special-shaped sealing ring; The lower end of the dispensing sleeve is connected to the upper end of the dispensing stirring shaft, and the outer wall of its upper end is hermetically connected to the inner wall of the upper end of the upper feeding cylinder through a fourth special-shaped sealing ring, and the top end is connected to the secondary stirring gear; The secondary stirring gear is rotatably installed at the lower end of the bearing seat through a bearing, and is connected to the power shaft of the stirring drive component through the primary stirring gear provided on one side.

10. The screw powder filling machine capable of being cleaned and sterilized online according to claim 1, wherein, The dispensing mechanism further includes a pressure balance hose and a diaphragm valve, where: The lower end of the pressure balance hose communicates with the inner cavity of the lower end of the lower feeding cylinder through a first quick connector, the upper end communicates with the inner cavity of the upper feeding cylinder through a second quick connector, and the diaphragm valve is installed on it.

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