Sample processing system

Abstract

The utility model relates to a sample processing system. The sample treatment system comprises a filter sleeve column, a cover opening and closing module, an overturning module, a centrifugal transfer module, a filter module and a carrying mechanism, the cover opening and closing module is used for configuring the filter sleeve column for an opening of a test tube loaded with a sample; the overturning module is used for overturning the test tube provided with the filter sleeve column; the centrifugal transfer module is used for centrifuging the overturned sample in the filter sleeve column; the filtering module is used for filtering a sample in the filtering sleeve column; and the carrying mechanism is used for carrying the test tubes and / or the filter sleeve columns among the cover opening and closing module, the overturning module, the centrifugal transfer module and the filter module. According to the scheme provided by the invention, the filtering efficiency can be improved, sample residues in the test tube are reduced, and sample waste is reduced.

Description

Technical Field

[0001] This application relates to the technical field of automated equipment, and particularly to a sample processing system. Background Art

[0002] In biochemical experiments, after the sample undergoes pretreatment operations such as dissolution, extraction, and preparation, post-treatment operations such as filtration, detection, and analysis of the prepared sample are often required. In practical applications, the prepared sample is generally stored in a test tube. When filtering the sample, it is necessary to first suck the sample out of the test tube and then transfer it into the filter column used in the filtering device for filtration. Such an operation not only has low filtration efficiency, but also it is very difficult to completely transfer the sample, and part of the sample will remain in the test tube, resulting in sample waste. Utility Model Content

[0003] To solve or partially solve the problems existing in the related art, this application provides a sample processing system, which can improve the filtration efficiency and reduce sample waste.

[0004] In the first aspect of this application, a sample processing system is provided, which includes a filter sleeve column, a switch cover module, a flipping module, a centrifugal transfer module, a filtering module, and a handling mechanism; the switch cover module is used to configure the filter sleeve column for the opening of the test tube loaded with the sample; the flipping module is used to flip the test tube configured with the filter sleeve column; the centrifugal transfer module is used to centrifuge the sample in the flipped filter sleeve column; the filtering module is used to filter the sample in the filter sleeve column; the handling mechanism is used to handle the test tube and / or the filter sleeve column between the switch cover module, the flipping module, the centrifugal transfer module, and the filtering module.

[0005] Further, the sample processing system further includes a first liquid adding module, and the first liquid adding module is used to add a first target liquid into the test tube loaded with the sample;

[0006] The first liquid adding module includes a liquid adding needle, a mounting seat, a liquid adding moving mechanism, a first control valve, and a first driving pump; the mounting seat is respectively connected to the liquid adding moving mechanism and the liquid adding needle, and the liquid adding moving mechanism is used to drive the mounting seat to move so as to drive the liquid adding needle to move; the first control valve is respectively communicated with the solvent bottle, the liquid adding needle, and the first driving pump, and the liquid adding needle is used to inject the first target liquid in the solvent bottle into the test tube loaded with the sample; the handling mechanism is used to transfer the test tube with the liquid adding completed to the switch cover module.

[0007] Further, the sample processing system further includes a mixing module, and the mixing module is used to mix the test tube loaded with the sample and the first target liquid;

[0008] The mixing module includes an oscillation mechanism and an oscillation clamping mechanism. The oscillation clamping mechanism is connected to the oscillation mechanism. The oscillation clamping mechanism is used to clamp a test tube, and the oscillation mechanism is used to drive the oscillation clamping mechanism to vibrate, so as to drive the test tube to shake; the handling mechanism is used to transfer the test tube equipped with the filter sleeve column to the mixing module, and after mixing is completed, transfer it to the flipping module.

[0009] Further, the sample processing system further includes a nitrogen blowing module, and the nitrogen blowing module is used to perform nitrogen blowing treatment on the sample in the test tube;

[0010] The nitrogen blowing module includes a first lifting mechanism, a nitrogen blowing needle, a connecting seat, a first translation mechanism, a bracket and a heating component. The nitrogen blowing needle is fixedly arranged on the connecting seat. The connecting seat is provided with an air passage, and the air passage communicates with the nitrogen blowing needle and a nitrogen source respectively; the first lifting mechanism is connected to the connecting seat, and the first lifting mechanism is used to drive the connecting seat to lift, so as to drive the nitrogen blowing needle to lift; the bracket is arranged on the first translation mechanism and is located below the nitrogen blowing needle. The bracket is used to place the test tube, and the first translation mechanism is used to drive the bracket to approach or move away from the nitrogen blowing needle; the heating component is arranged on the first translation mechanism, and the heating component is used to heat the test tube on the bracket.

[0011] Further, the handling mechanism includes a first moving mechanism, a second moving mechanism, a third moving mechanism and a handling clamping component; the second moving mechanism is arranged on the first moving mechanism, and the first moving mechanism is used to drive the second moving mechanism to move along a first direction; the third moving mechanism is arranged on the second moving mechanism, and the second moving mechanism is used to drive the third moving mechanism to move along a second direction; the handling clamping component is arranged on the third moving mechanism, and the third moving mechanism is used to drive the handling clamping component to move along a third direction; wherein, the first direction, the second direction and the third direction are perpendicular to each other in pairs, and the handling clamping component is used to clamp the test tube and / or the filter sleeve column.

[0012] Further, the handling clamping component includes at least two clamping jaws arranged at intervals along the length direction of the third moving mechanism. At least one of the clamping jaws is fixedly connected to the third moving mechanism in the length direction of the third moving mechanism, and the remaining clamping jaws are movably connected to the third moving mechanism in the length direction of the third moving mechanism.

[0013] Further, the switch cover module includes a bottle cap clamping mechanism and a bottle body clamping mechanism located below the bottle cap clamping mechanism. The bottle body clamping mechanism is used to clamp the test tube, and the bottle cap clamping mechanism is used to clamp the bottle cap or the filter sleeve column;

[0014] The bottle cap clamping mechanism includes a lifting assembly, a rotating assembly, and a first clamping member. The lifting assembly is connected to the rotating assembly, the rotating assembly is connected to the first clamping member. The first clamping member is used for clamping the bottle cap or the filter sleeve column. The rotating assembly is used to drive the first clamping member to rotate. The lifting assembly is used to drive the rotating assembly to lift or lower, so that the first clamping member approaches or moves away from the test tube.

[0015] The bottle body clamping mechanism includes a translation assembly, a support base, a second clamping member, and a sleeve column placement position. The support base is arranged on the translation assembly. The second clamping member and the sleeve column placement position are arranged on the support base. The second clamping member is used for clamping the test tube. The sleeve column placement position is used for placing the filter sleeve column. The translation assembly is used to drive the second clamping member or the sleeve column placement position to move below the first clamping member. The first clamping member is used for clamping the filter sleeve column and configuring the filter sleeve column at the opening of the test tube.

[0016] Further, the centrifugal transfer module includes a horizontal rotor, a plurality of hanging baskets, and a centrifugal rotation mechanism. The centrifugal rotation mechanism is connected to the horizontal rotor. The centrifugal rotation mechanism is used to drive the horizontal rotor to rotate. A plurality of the hanging baskets are evenly arranged on the horizontal rotor. The hanging baskets are used for placing test tubes.

[0017] The horizontal rotor includes a square base plate and two support rods arranged at each vertex angle of the base plate. The two support rods at each vertex angle extend outward along two sides of the base plate. The hanging basket is arranged between two parallel support rods at adjacent vertex angles, or the hanging basket is arranged between the two support rods at any vertex angle.

[0018] Further, the sample processing system further includes a barcode scanning module. The barcode scanning module includes a barcode scanner, a test tube holder, and a barcode scanning rotation mechanism. The test tube holder is used for placing test tubes. The barcode scanning rotation mechanism is connected to the test tube holder. The barcode scanning rotation mechanism is used to drive the test tube holder to rotate. The barcode scanner is used for scanning test tubes.

[0019] Further, the test tube holder includes a first test tube holder and a second test tube holder. The barcode scanning rotation mechanism includes a drive motor, a first gear, and a second gear. The first test tube holder is fixedly connected to the first gear. The second test tube holder is fixedly connected to the second gear. The first gear meshes with the second gear. The drive motor is drivingly connected to the first gear or the second gear. The drive motor is used to drive the first gear or the second gear to rotate, so as to drive the first test tube holder and the second test tube holder to rotate; or

[0020] The code scanning and rotating mechanism includes a driving motor, a first synchronous pulley, a second synchronous pulley and a synchronous belt. The first test tube seat is fixedly connected to the first synchronous pulley, the second test tube seat is fixedly connected to the second synchronous pulley, the synchronous belt is wound around the first synchronous pulley and the second synchronous pulley, the driving motor is drivingly connected to the first synchronous pulley or the second synchronous pulley, and the driving motor is used to drive the first synchronous pulley or the second synchronous pulley to rotate, so as to drive the first test tube seat and the second test tube seat to rotate.

[0021] Further, the sample processing system further includes a loading and unloading module, and the loading and unloading module is used to place test tubes and / or filter column sleeves;

[0022] The loading and unloading module is provided with a plurality of material placement positions, and each material placement position is provided with a positioning mechanism and / or a sensing mechanism. The positioning mechanism is used to position the tray carrying the test tube and / or the filter column sleeve, and the sensing mechanism is used to sense the usage state of the material placement position; the positioning mechanism includes at least one of a positioning pin, a limiting bar, and a magnetic attracting member.

[0023] Further, the filter column sleeve includes a first tube body, a second tube body and a connecting member. The first tube body is communicated with the second tube body. One end of the first tube body away from the second tube body is provided with a first opening, and one end of the second tube body away from the first tube body is provided with a second opening; the connecting member is arranged at one end of the first tube body close to the first opening, and the connecting member is used to connect the first tube body and the test tube loading the sample, and a liquid flow channel for communicating the first tube body and the test tube is arranged in the connecting member;

[0024] Wherein, the inner diameter of the first tube body is larger than the inner diameter of the second tube body.

[0025] Further, the liquid flow channel includes a first liquid flow channel and a second liquid flow channel which are communicated with each other. The first liquid flow channel is on the side close to the test tube, and the second liquid flow channel is on the side close to the first tube body; the inner diameter of the first liquid flow channel is larger than the inner diameter of the second liquid flow channel;

[0026] The axes of the first liquid flow channel, the second liquid flow channel, the first tube body and the second tube body are all collinear.

[0027] Further, the connecting member is in interference fit with the test tube; or

[0028] Internal threads are provided on the inner wall of one end of the connecting member connected to the test tube, external threads are provided on the outer wall of the test tube close to the opening, and the internal threads are in threaded connection with the external threads so that the filter column sleeve is configured at the opening of the test tube.

[0029] Further, the filter sleeve column further includes a plug, which is detachably connected to one end of the second tube body away from the first tube body, and the plug is used to block the second opening before filtration.

[0030] Further, the filter sleeve column further includes a filter element, which is arranged in the first tube body and near one end of the second tube body, and the filter element is used to filter the sample in the first tube body.

[0031] Further, the filter module includes a support frame and a filter module group, and the filter module group is arranged on the support frame; wherein, the filter module group includes a filter clamping jaw assembly and a pressure regulating mechanism;

[0032] The filter clamping jaw assembly includes a first driving mechanism and a filter clamping jaw which is drivingly connected to the first driving mechanism. The first driving mechanism is arranged on the support frame, and the first driving mechanism is used to drive the filter clamping jaw to clamp the filter sleeve column;

[0033] The pressure regulating mechanism is used to communicate with the filter sleeve column and adjust the air pressure in the filter sleeve column so as to filter the sample in the filter sleeve column.

[0034] Further, the filter module group further includes an adapter, which is arranged on the support frame and above the filter clamping jaw. One end of the adapter is connected to the pressure regulating mechanism, and the other end of the adapter is used for sealing connection with the filter sleeve column;

[0035] The adapter has a first channel, and the first channel is used to communicate the filter sleeve column with the pressure regulating mechanism.

[0036] Further, the pressure regulating mechanism includes a positive pressure component and a pressure relief component; one end of the pressure relief component is communicated with the first channel, and the other end is communicated with the atmospheric environment. The pressure relief component is used to relieve the pressure of the filter sleeve column when the adapter is connected to the filter sleeve column; one end of the positive pressure component is communicated with the first channel, and the other end is communicated with a gas source. The positive pressure component is used to pressurize the filter sleeve column.

[0037] Further, the pressure regulating mechanism further includes a negative pressure component, which is communicated with the first channel, and the negative pressure component is used to form a negative pressure in the filter sleeve column.

[0038] Further, the filter module group further includes a second liquid adding module. One end of the second liquid adding module is communicated with a solvent bottle, and the other end is communicated with the adapter. The second liquid adding module is used to convey a second target liquid into the filter sleeve column;

[0039] The adapter also has a second channel, and the second channel is used to communicate the filter sleeve column with the second liquid adding module.

[0040] Further, the filtering module further includes a second lifting mechanism disposed on the support frame. The filtering module is drivingly connected to the second lifting mechanism, and the second lifting mechanism is configured to drive the filtering module to lift; and / or

[0041] The filtering module further includes a third lifting mechanism disposed on the support frame. The adapter is drivingly connected to the third lifting mechanism, and the third lifting mechanism is configured to drive the adapter to approach or move away from the filtering jaw.

[0042] Further, the filtering module further includes a base and a placement rack located on the base. The placement rack is provided with at least one first placement position for placing a liquid collection bottle;

[0043] The filtering module further includes a second translation mechanism and / or a third translation mechanism. The base is disposed on the second translation mechanism, and the second translation mechanism is configured to drive the base to move along a fourth direction so that the liquid collection bottle on the placement rack approaches or moves away from the filtering jaw; the third translation mechanism is disposed on the support frame and connected to the filtering module, and the third translation mechanism is configured to drive the filtering module to move along a fifth direction so that the filtering jaw approaches or moves away from the liquid collection bottle; wherein, the fourth direction is parallel or perpendicular to the fifth direction.

[0044] Further, the filtering module further includes a fixed clamping assembly disposed on the base;

[0045] The fixed clamping assembly includes a second driving mechanism and a fixed jaw drivingly connected to the second driving mechanism. The second driving mechanism is configured to drive the fixed jaw to clamp the filtering sleeve column, and the fixed jaw cooperates with the filtering jaw or the handling mechanism to separate the test tube and the connecting member from the first tube body.

[0046] Further, the filtering sleeve column further includes a plug detachably connected to an end of the second tube body away from the first tube body, and the plug is configured to block the second opening before filtering;

[0047] The filtering module further includes a unloading member located below the filtering jaw, and the unloading member is configured to separate the plug from the second tube body.

[0048] Further, the placement rack is further provided with at least one second placement position for placing a filter head; after the unloading member removes the plug, the filtering jaw drives the filtering sleeve column to pick up the filter head.

[0049] Further, the filtering module further includes a recycling component disposed on the base, and the unloading member is located above the recycling component;

[0050] The filtering module further includes a detector disposed on the base, and the detector is used to detect whether the filtering sleeve column picks up the filter head.

[0051] Further, the sample processing system further includes a marking machine, and the marking machine is used to code the liquid collection bottle and / or the test tube.

[0052] The technical solution provided by the present application may include the following beneficial effects: By setting the switch cover module to configure the filtering sleeve column for the test tube, and then flipping the test tube configured with the filtering sleeve column through the flipping module, the process of sucking the sample from the test tube and then transferring it into the filtering sleeve column is reduced, and the filtering efficiency is improved; By centrifuging the sample through the centrifugal transfer module, all the samples in the test tube enter the filtering sleeve column, reducing the residue of the sample in the test tube and avoiding sample waste; By filtering the sample in the filtering sleeve column through the filtering module, the automation of the filtering operation is realized, which not only reduces the workload of the experimental personnel, but also improves the filtering efficiency.

[0053] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the present application. Description of the Drawings

[0054] By describing the exemplary embodiments of the present application in more detail in conjunction with the drawings, the above and other objects, features, and advantages of the present application will become more obvious. Among them, in the exemplary embodiments of the present application, the same reference numerals generally represent the same components.

[0055] Figure 1 is a schematic structural diagram of the sample processing system shown in the embodiment of the present application;

[0056] Figure 2 is a schematic structural diagram of the switch cover module shown in the embodiment of the present application;

[0057] Figure 3 is a schematic structural diagram of the flipping module shown in the embodiment of the present application;

[0058] Figure 4 is a schematic structural diagram of the centrifugal transfer module shown in the embodiment of the present application;

[0059] Figure 5 is a schematic structural diagram of the first liquid addition module shown in the embodiment of the present application;

[0060] Figure 6 is a schematic structural diagram of the mixing module shown in the embodiment of the present application;

[0061] Figure 7 It is a schematic structural diagram of the nitrogen blowing module shown in the embodiments of the present application;

[0062] Figure 8 It is a schematic structural diagram of the handling mechanism shown in the embodiments of the present application;

[0063] Figure 9 It is a schematic structural diagram of the handling and clamping assembly shown in the embodiments of the present application;

[0064] Figure 10 It is a schematic structural diagram of the barcode scanning module shown in the embodiments of the present application;

[0065] Figure 11 It is a schematic structural diagram of the filter sleeve column after removing the connecting piece shown in the embodiments of the present application;

[0066] Figure 12 It is a cross-sectional view of the filter sleeve column after removing the connecting piece shown in the embodiments of the present application;

[0067] Figure 13 It is a schematic connection diagram of the filter sleeve column and the test tube shown in the embodiments of the present application;

[0068] Figure 14 is Figure 13 cross-sectional view;

[0069] Figure 15 It is a schematic structural diagram of the filter module shown in the embodiments of the present application;

[0070] Figure 16 It is a schematic structural diagram of the filter module group shown in the embodiments of the present application;

[0071] Figure 17 It is a schematic structural diagram of the placement rack shown in the embodiments of the present application;

[0072] Figure 18 It is a structural block diagram of the pressure regulating mechanism shown in the embodiments of the present application;

[0073] Figure 19 It is a schematic plan view of the sample processing system shown in the embodiments of the present application.

[0074] Reference numerals: filter sleeve column 1; first tube body 11; first opening 111; second tube body 12; second opening 121; connecting piece 13; first liquid flow channel 131; second liquid flow channel 132; plug 14; switch cover module 2; base 21; bottle cap recycling part 211; bottle cap clamping mechanism 22; lifting assembly 221; rotating assembly 222; first clamping piece 223; bottle body clamping mechanism 23; translation assembly 231; support seat 232; second clamping piece 233; sleeve column placement position 234; flipping module 3; flipping motor 31; flipping clamping piece 32; centrifugal transfer module 4; horizontal rotor 41; substrate 411; support rod 412; hanging basket 42; filtering module 5; support frame 51; filtering module group 52; first driving mechanism 521; filtering gripper 522; adapter 523; third lifting mechanism 524; first switching valve 525; second switching valve 526; proportional valve 527; digital display meter 529; second lifting mechanism 53; base 54; placement rack 55; first placement position 551; second placement position 552; second translation mechanism 56; third translation mechanism 57; fixed clamping assembly 58; second driving mechanism 581; fixed gripper 582; recycling assembly 59; consumable recycling box 591; waste liquid pool 592; buffer box 593; unloading part 501; detector 502; liquid collection bottle 503; filter head 504; handling mechanism 6; first moving mechanism 61; second moving mechanism 62; third moving mechanism 63; handling clamping assembly 64; mounting plate 641; adjustment mechanism 65; base frame 66; first liquid adding module 7; liquid adding needle 71; mounting seat 72; liquid adding moving mechanism 73; cleaning pool 74; mixing module 8; oscillating mechanism 81; oscillating clamping mechanism 82; mixing support 83; mixing guide rail 831; nitrogen blowing module 9; first lifting mechanism 91; nitrogen blowing needle 92; connecting seat 93; first translation mechanism 94; bracket 95; heating assembly 96; air extraction pipeline 97; scanning code module 10; scanning code gun 101; first test tube seat 102; second test tube seat 103; driving motor 104; first gear 105; second gear 106; test tube 100; loading and unloading module 200; marking machine 300; workbench 400; transfer module 500; robotic arm 600; material rack 700; atmospheric environment 800. Detailed implementation manners

[0075] The embodiments of the present application will be described in more detail below with reference to the accompanying drawings. Although the embodiments of the present application are shown in the drawings, it should be understood that the present application can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided to make the present application more thorough and complete, and to be able to fully convey the scope of the present application to those skilled in the art.

[0076] It should be understood that although the terms "first", "second", "third", etc. may be used in this application to describe various pieces of information, such information should not be limited to these terms. These terms are only used to distinguish information of the same type from each other. For example, without departing from the scope of this application, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of this application, the meaning of "a plurality" is two or more unless otherwise specifically defined.

[0077] In the description of this application, it should be understood that the orientation or positional relationship indicated by the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing this application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation of this application.

[0078] Unless otherwise clearly defined and limited, the terms "mounted", "connected", "connected to", "fixed", etc. should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or integrated; it may be a mechanical connection or an electrical connection; it may be directly connected or indirectly connected through an intermediate medium, and it may be the communication inside two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0079] In view of the above problems, an embodiment of this application provides a sample processing system, which can improve the filtration efficiency and reduce sample waste.

[0080] The technical solutions of the embodiments of this application will be described in detail below with reference to the drawings.

[0081] See Figure 1 and Figure 19, the sample processing system includes a filter sleeve column 1, a switch cover module 2, a flipping module 3, a centrifugal transfer module 4, a filtering module 5, and a handling mechanism 6. The switch cover module 2 is used to configure the filter sleeve column 1 at the opening of the test tube 100 loaded with the sample. In one embodiment, in order to facilitate the configuration of the filter sleeve column 1 at the opening of the test tube 100, the switch cover module 2 can store several filter sleeve columns 1; in another embodiment, a storage rack can be configured near the switch cover module 2, and the storage rack is used to store the filter sleeve columns 1. When it is necessary to configure the filter sleeve column 1 at the opening of the test tube 100, the filter sleeve column 1 is transferred from the storage rack to the switch cover module 2. It can be understood that if the test tube 100 is initially equipped with a test tube cap, the switch cover module 2 first opens the cap of the test tube 100 and then configures the filter sleeve column 1. One or more switch cover modules 2 can be provided. When multiple switch cover modules 2 are provided, the filter sleeve column 1 can be configured for multiple test tubes 100 simultaneously, thereby improving the experimental throughput. Among them, the switch cover module 2, the flipping module 3, the centrifugal transfer module 4, and the filtering module 5 can be arranged on the workbench 400.

[0082] See Figure 1 , Figure 3 and Figure 19 , the flipping module 3 is used to flip the test tube 100 configured with the filter sleeve column 1. The flipping module 3 includes a flipping motor 31 and a flipping clamping member 32. The flipping motor 31 is connected to the flipping clamping member 32. The flipping motor 31 can drive the flipping clamping member 32 to rotate 180 degrees, and the flipping clamping member 32 can clamp and fix the test tube 100. Before the filter sleeve column 1 is configured on the test tube 100, the opening of the test tube 100 faces upward and the sample is at the bottom of the test tube 100. When the filter sleeve column 1 is configured on the test tube 100, the filter sleeve column 1 is installed at the top of the test tube 100, and the handling mechanism 6 sends the test tube 100 configured with the filter sleeve column 1 to the flipping module 3. The flipping module 3 flips the test tube 100 configured with the filter sleeve column 1 by 180 degrees, so that the filter sleeve column 1 is below the test tube 100, and at this time the sample in the test tube 100 falls into the filter sleeve column 1. In one example, the flipping clamping member 32 includes two clamping rods arranged in parallel. Both clamping rods are drivingly connected to the flipping motor 31, and the flipping motor 31 can also drive the two clamping rods to approach or separate from each other to clamp or release the test tube 100. Clamping grooves are provided on one side of the two clamping rods facing each other, and the clamping grooves of the two clamping rods cooperate with each other to clamp the test tube 100. Among them, the clamping groove can be in the shape of an arc, V-shaped, U-shaped, etc., and is not limited here. Multiple clamping grooves can be provided on each clamping rod, which can realize clamping and flipping of multiple test tubes 100 simultaneously, thereby improving the experimental throughput.

[0083] See Figure 1 and Figure 4, the centrifugal transfer module 4 is used to centrifuge the sample in the inverted filter sleeve column 1. The filtration module 5 is used to filter the sample in the filter sleeve column 1. That is, after the sample in the filter sleeve column 1 is centrifuged, it is then filtered by the filtration module 5. The handling mechanism 6 can transfer the test tube 100 or the filter sleeve column 1 between the switch cover module 2, the flipping module 3, the centrifugal transfer module 4 and the filtration module 5, or can also transfer the test tube 100 configured with the filter sleeve column 1 between the switch cover module 2, the flipping module 3, the centrifugal transfer module 4 and the filtration module 5. After the switch cover module 2 configures the filter sleeve column 1 for the test tube 100, the handling mechanism 6 can transfer the test tube 100 configured with the filter sleeve column 1 to the flipping module 3, and the flipping module 3 then flips the test tube 100 configured with the filter sleeve column 1 up and down, so that the sample in the test tube 100 enters the filter sleeve column 1; the handling mechanism 6 then transfers the flipped test tube 100 and the filter sleeve column 1 to the centrifugal transfer module 4, and the centrifugal transfer module 4 centrifuges the sample in the filter sleeve column 1 to make the sample in the test tube 100 transfer to the filter sleeve column 1 as much as possible, reducing the residue of the sample in the test tube 100; the handling mechanism 6 then transfers the centrifuged filter sleeve column 1 and the test tube 100 to the filtration module 5, and the filtration module 5 removes the test tube 100 on the filter sleeve column 1 and then filters the sample in the filter sleeve column 1.

[0084] In this application, by setting the switch cover module 2 to configure the filter sleeve column 1 for the test tube 100, and then flipping the test tube 100 configured with the filter sleeve column 1 through the flipping module 3, the process of sucking out the sample from the test tube 100 and then transferring it into the filter sleeve column 1 is reduced, improving the filtration efficiency; by centrifuging the sample through the centrifugal transfer module 4, all the sample in the test tube 100 enters the filter sleeve column 1, reducing the residue of the sample in the test tube 100 and avoiding sample waste; by filtering the sample in the filter sleeve column 1 through the filtration module 5, the automation of the filtration operation is realized, which not only reduces the workload of the experimental personnel, but also improves the filtration efficiency.

[0085] See Figure 1 and Figure 5, in some embodiments, the sample processing system further includes a first liquid addition module 7. The first liquid addition module 7 is used to add a first target liquid into a test tube 100 loaded with a sample. The first liquid addition module 7 includes a liquid addition needle 71, a mounting seat 72, a liquid addition moving mechanism 73, a first control valve, and a first drive pump. The mounting seat 72 is respectively connected to the liquid addition moving mechanism 73 and the liquid addition needle 71. Specifically, the mounting seat 72 is fixedly connected to the liquid addition needle 71, and the mounting seat 72 is drivingly connected to the liquid addition moving mechanism 73. The liquid addition moving mechanism 73 drives the mounting seat 72 to move, so as to drive the liquid addition needle 71 to move. The liquid addition moving mechanism 73 can drive the liquid addition needle 71 to move between different test tubes 100, so that the needle opening of the liquid addition needle 71 is aligned with the openings of different test tubes 100. It can be understood that multiple liquid addition needles 71 can be provided. The multiple liquid addition needles 71 can be synchronously driven by the liquid addition moving mechanism 73 to move (for example, multiple liquid addition needles 71 are evenly installed on the same mounting seat 72), or the multiple liquid addition needles 71 can be respectively driven by the liquid addition moving mechanism 73 to move (for example, each liquid addition needle 71 is arranged on a different mounting seat 72, and each mounting seat 72 is independently driven by the liquid addition moving mechanism 73 to move). By providing multiple liquid addition needles 71, multiple test tubes 100 can be liquid-added simultaneously, which can improve the experimental throughput.

[0086] The first control valve is respectively connected to a solvent bottle, the liquid addition needle 71, and the first drive pump. The first control valve has multiple interfaces. The first control valve can be connected to multiple solvent bottles containing different target liquids through the multiple interfaces. The liquid addition needle 71 is used to inject the first target liquid in the solvent bottle into the test tube 100 loaded with a sample. When the liquid addition needle 71 needs to add the first target liquid to the test tube 100 loaded with a sample, under the action of the first drive pump, the first target liquid in the solvent bottle flows from the solvent bottle to the first control valve, then from the first control valve to the liquid addition needle 71, and finally is injected into the test tube 100 loaded with a sample from the liquid addition needle 71. After the first liquid addition module 7 adds the first target liquid to the test tube 100 loaded with a sample, the handling mechanism 6 can transfer the test tube 100 with the liquid addition completed to the switch cover module 2, and the switch cover module 2 configures the filter sleeve column 1 on the test tube 100 with the liquid addition completed. The first target liquid can be prepared according to experimental requirements and is not limited herein. The first control valve can be an electromagnetic valve or an electric valve, etc. Preferably, the first control valve is a multi-channel electromagnetic valve (such as a three-way electromagnetic valve, a six-way electromagnetic valve, etc.). The first drive pump can be an electric reciprocating pump (such as a plunger pump, a diaphragm pump, a piston pump, etc.) or a steam reciprocating pump. Preferably, the first drive pump is a plunger pump.

[0087] In some of these embodiments, the first liquid addition module 7 can be a pipette gun, which realizes the function of adding the target liquid by sucking the first target liquid from the solvent bottle and then spitting it into the test tube 100 loaded with a sample.

[0088] SeeFigure 1 and Figure 5 The sample processing system further includes a liquid adding and cleaning assembly. The liquid adding and cleaning assembly includes a cleaning pool 74, a second control valve, a second driving pump, and a waste liquid bottle. The second control valve is respectively communicated with the cleaning pool 74, the second driving pump, and the waste liquid bottle. In one example, after the liquid adding needle 71 injects the solvent in the first solvent bottle into the test tube 100, if it is necessary to inject the solvent in the second solvent bottle, in order to avoid the first solvent remaining in the liquid adding needle 71 and the pipeline from contaminating the second solvent, it is necessary to first clean the liquid adding needle 71 and the pipeline with the solvent in the second solvent bottle. Specifically, the liquid adding moving mechanism 73 first moves the liquid adding needle 71 to the cleaning pool 74. The solvent in the second solvent bottle flows to the first control valve under the action of the first driving pump, then flows from the first control valve to the liquid adding needle 71, and finally is injected into the cleaning pool 74 from the liquid adding needle 71, that is, the inner wall of the liquid adding needle 71 and the pipeline are cleaned. The cleaning pool 74 also has the function of storing liquid. When enough solvent in the second solvent bottle flows out, the outer wall of the liquid adding needle 71 can be cleaned. The cleaning pool 74 can discharge the liquid in the cleaning pool 74 to the waste liquid bottle by using the second control valve and the second driving pump. If it is not necessary to clean the outer wall of the liquid adding needle 71, the cleaning pool 74 can also be directly communicated with the waste liquid bottle. The liquid discharged from the liquid adding needle 71 falls into the cleaning pool 74, and the cleaning pool 74 directly discharges the liquid to the waste liquid bottle. Among them, the structures of the second control valve and the first control valve can be the same or similar, and the structures of the second driving pump and the first driving pump can be the same or similar.

[0089] See Figure 1 and Figure 6 The sample processing system further includes a mixing module 8. The mixing module 8 is used to mix the test tube 100 loaded with the sample and the first target liquid, so that the sample is dissolved in the first target liquid. In some embodiments, the mixing module 8 includes an oscillating mechanism 81 and an oscillating clamping mechanism 82. The oscillating clamping mechanism 82 is connected to the oscillating mechanism 81. The oscillating clamping mechanism 82 is used to clamp the test tube 100, and the oscillating mechanism 81 is used to drive the oscillating clamping mechanism 82 to vibrate, so as to drive the test tube 100 to shake. Specifically, the oscillating mechanism 81 can drive the oscillating clamping mechanism 82 to vibrate vertically and / or horizontally.

[0090] In one example, the mixing module 8 includes a mixing support 83, on which there is a mixing guide rail 831 extending in the vertical direction; the oscillation mechanism 81 can be driven by a motor or a cylinder, preferably, the oscillation mechanism 81 is a voice coil motor, which is fixed on the mixing support 83; the oscillation clamping mechanism 82 is installed on the mixing guide rail 831 and is drivingly connected to the output end of the voice coil motor, and the oscillation clamping mechanism 82 can move up and down along the mixing guide rail 831. The oscillation clamping mechanism 82 includes a driving member and mixing jaws connected to the driving member, and the driving member can be driven by a motor or a cylinder; the mixing jaws can include two clamping blocks, and a plurality of clamping grooves can be provided on each clamping block. The driving member drives the two clamping blocks to approach each other, so that the clamping grooves on the two clamping blocks cooperate with each other to be able to clamp a plurality of test tubes 100 at the same time, so as to improve the experimental throughput. After the mixing jaws clamp the test tube 100, the voice coil motor drives the mixing jaws to move up and down repeatedly, and the test tube 100 moves up and down repeatedly accordingly, so as to realize the mixing of the sample and the first target liquid in the test tube 100.

[0091] In some of these embodiments, the mixing module 8 can be a mechanical stirring module or an electromagnetic stirring module. When it is a mechanical stirring module, the stirring rod extends into the test tube 100 to mechanically stir the sample in the test tube 100, so as to make the sample and the first target liquid evenly stirred. When it is an electromagnetic stirring module, a stir bar is placed in the test tube 100, and the stir bar is driven by a magnet to rotate to perform electromagnetic stirring on the sample in the test tube 100. The structures of the mechanical stirring module and the electromagnetic stirring module are not limited, and can be implemented by using relevant existing technologies.

[0092] After the first liquid adding module 7 adds liquid to the test tube 100 loaded with the sample, the handling mechanism 6 transfers the test tube 100 with the liquid added to the switch cover module 2, the switch cover module 2 configures the filter sleeve column 1 on the test tube 100, and the handling mechanism 6 then transfers the test tube 100 with the filter sleeve column 1 configured to the mixing module 8. After mixing is completed, the mixed test tube 100 and the filter sleeve column 1 are transferred to the flipping module 3.

[0093] See Figure 1 and Figure 7, in some embodiments, in order to meet specific experimental requirements to control the sample concentration, the sample can be concentrated. To this end, the sample processing system may further include a nitrogen blowing module 9, and the nitrogen blowing module 9 is used to perform nitrogen blowing treatment on the sample in the test tube 100. The nitrogen blowing module 9 includes a first lifting mechanism 91, a nitrogen blowing needle 92, a connecting seat 93, a first translation mechanism 94, a bracket 95 and a heating component 96. The nitrogen blowing needle 92 is fixedly arranged on the connecting seat 93, and the connecting seat 93 is provided with an air duct, and the air duct communicates with the nitrogen blowing needle 92 and the nitrogen source respectively. The nitrogen source can transport nitrogen to the nitrogen blowing needle 92 through the air duct. Among them, the nitrogen source can be an external nitrogen cylinder or a nitrogen tank in the nitrogen blowing module 9. The first lifting mechanism 91 is connected to the connecting seat 93, and the first lifting mechanism 91 is used to drive the connecting seat 93 to lift, so as to drive the nitrogen blowing needle 92 to lift. The connecting seat 93 and the first lifting mechanism 91 can be fixedly connected by screws, or can be quickly replaced by pneumatic or magnetic attraction methods, which are not limited here. The first lifting mechanism 91 can be a cylinder, a linear motor or a screw slide table module, etc. A flow stabilizer plate and a confluence plate can be arranged inside the connecting seat 93, so that nitrogen can enter each nitrogen blowing needle 92 connected to the connecting seat 93 evenly. The bracket 95 is arranged on the first translation mechanism 94, and the bracket 95 is located below the nitrogen blowing needle 92. The bracket 95 is used to place the test tube 100, and the nitrogen blowing needle 92 can blow nitrogen on the test tube 100 in the bracket 95. The first translation mechanism 94 is used to drive the bracket 95 to approach or move away from the nitrogen blowing needle 92. The heating component 96 is arranged on the first translation mechanism 94, and the heating component 96 is used to heat the test tube 100 on the bracket 95, so as to evaporate the water in the sample and concentrate the sample. Cooperating with the nitrogen blowing needle 92 to blow nitrogen on the sample can further improve the concentration effect of the sample. Among them, the heating component 96 can be a heating film attached to the bottom and / or side of the bracket 95, or a heating rod arranged inside the bracket 95, or a water bath heating, etc., which are not limited here. An exhaust duct 97 can be arranged near the bracket 95, and the exhaust duct 97 is connected to an exhaust device, which can timely suck away the volatile substances generated in the test tube 100 to ensure the safety of the experiment. In order to improve the experimental throughput, a plurality of nitrogen blowing modules 9 can be set.

[0094] In one example, the handling mechanism 6 can first transfer the test tube 100 to the nitrogen blowing module 9 for nitrogen blowing, and then the handling mechanism 6 transfers the nitrogen blown test tube 100 to the first liquid adding module 7, and adds the first target liquid into the nitrogen blown and concentrated test tube 100 through the first liquid adding module 7. In another example, the handling mechanism 6 can first transfer the test tube 100 to the nitrogen blowing module 9 for nitrogen blowing. After the sample in the test tube 100 is concentrated to a certain concentration, the handling mechanism 6 directly transfers the test tube 100 to the switch cover module 2 for configuring the filter column 1.

[0095] It can be understood that, in order to save system space and make the structure more compact, the first liquid addition module 7 and the nitrogen blowing module 9 can be arranged adjacent to each other front and back. The first translation mechanism 94 and the bracket 95 are located below the liquid addition needle 71. The first translation mechanism 94 can drive the bracket 95 to move back and forth below the nitrogen blowing needle 92 and the liquid addition needle 71.

[0096] Refer to Figure 1 and Figure 8 , the handling mechanism 6 includes a first moving mechanism 61, a second moving mechanism 62, a third moving mechanism 63 and a handling clamping assembly 64. The second moving mechanism 62 is arranged on the first moving mechanism 61, and the first moving mechanism 61 is used to drive the second moving mechanism 62 to move along the first direction. The third moving mechanism 63 is arranged on the second moving mechanism 62, and the second moving mechanism 62 is used to drive the third moving mechanism 63 to move along the second direction. The first moving mechanism 61, the second moving mechanism 62, and the third moving mechanism 63 can adopt a lead screw slide module, a linear motor or a cylinder, etc. The handling clamping assembly 64 is arranged on the third moving mechanism 63, and the third moving mechanism 63 is used to drive the handling clamping assembly 64 to move along the third direction. Among them, the first direction, the second direction, and the third direction are perpendicular to each other in pairs, and the handling clamping assembly 64 is used to clamp the test tube 100 and / or the filter sleeve column 1. Preferably, the first direction is the x-axis direction, the second direction is the y-axis direction, and the third direction is the z-axis direction. By using the handling mechanism 6 to handle the test tube 100 and / or the filter sleeve column 1, the test tube 100 and / or the filter sleeve column 1 can be moved in multiple directions, which is convenient for the transfer of the test tube 100 and / or the filter sleeve column 1 between the switch cover module 2, the flipping module 3, the centrifugal transfer module 4, the filtering module 5, the first liquid addition module 7, the mixing module 8, and the nitrogen blowing module 9.

[0097] In some embodiments, the handling mechanism 6 further includes a base frame 66, and the first moving mechanism 61 is installed on the base frame 66, and the base frame 66 can be fixed on the workbench 400. In some embodiments, the sample processing system further includes an outer cover, and the outer cover is arranged on the workbench 400 and surrounds the switch cover module 2, the flipping module 3, the centrifugal transfer module 4, and the filtering module 5. The outer cover can protect the switch cover module 2, the flipping module 3, the centrifugal transfer module 4, and the filtering module 5 to form an independent experimental space. The first moving mechanism 61 can be directly installed on the outer cover, such as being arranged on the top plate of the outer cover. An interaction door is provided on the outer cover to facilitate the interaction between the sample processing system and the outside world. An observation window can also be provided on the outer cover to facilitate the experimenter to view the experimental dynamics.

[0098] It can be understood that the handling mechanism 6 can also be a multi-degree-of-freedom manipulator with a handling clamping assembly 64, which is not limited herein.

[0099] Refer to Figure 1 , Figure 8 and Figure 9, in some embodiments, the handling and clamping assembly 64 includes at least two jaws arranged at intervals along the length direction of the third moving mechanism 63 (such as the x-axis direction shown in Figure 8 ). At least one of the jaws is fixedly connected to the third moving mechanism 63 in the length direction of the third moving mechanism 63, and the remaining jaws are movably connected to the third moving mechanism 63 in the length direction of the third moving mechanism 63. The distance between the jaws can be adaptively adjusted according to the size of the test tube 100. Specifically, the distance between two adjacent jaws can be adjusted by a lead screw and slide table module, a linear motor, a cylinder, etc.

[0100] In one example, the handling and clamping assembly 64 further includes a mounting plate 641 and an adjustment mechanism 65. Among them, the mounting plate 641 is drivingly connected to the third moving mechanism 63 and is driven by the third moving mechanism 63 to move up and down. The adjustment mechanism 65 is fixed on the mounting plate 641. There are at least two jaws, at least one of the jaws is fixed to the mounting plate 641, and the remaining jaws are drivingly connected to the adjustment mechanism 65. The adjustment mechanism 65 can drive the jaws to move in the length direction of the third moving mechanism 63. For example, there are two jaws, one jaw is fixedly connected to the mounting plate 641, and the other jaw is drivingly connected to the adjustment mechanism 65. The distance between the two jaws can be adjusted by the adjustment mechanism 65. The adjustment mechanism 65 can be a lead screw and slide table module or a cylinder, etc. By arranging multiple jaws on the third moving mechanism 63, it is convenient for the handling and clamping assembly 64 to move multiple test tubes 100 and / or filter sleeve columns 1 at the same time, improving the working efficiency of the sample processing system.

[0101] See Figure 1 and Figure 2 , in some embodiments, the switch cover module 2 includes a base 21, a bottle cap clamping mechanism 22 and a bottle body clamping mechanism 23 located below the bottle cap clamping mechanism 22. The bottle cap clamping mechanism 22 and the bottle cap clamping mechanism 22 are installed on the base 21. Optionally, the base 21 may further be provided with a bottle cap recycling member 211 for recycling the bottle caps removed from the test tubes 100. The bottle body clamping mechanism 23 is used to clamp the test tube 100, and the bottle cap clamping mechanism 22 is used to clamp the bottle cap or the filter sleeve column 1. In order to ensure that the samples in the test tubes 100 are not affected by oxidation or volatilization, before installing the filter sleeve column 1 on the test tube 100 or before blowing nitrogen into the filter sleeve column 1, a bottle cap is installed at the opening of the test tube 100 to block the opening of the test tube 100, thereby protecting the samples in the test tube 100 and ensuring the correctness of the detection data. When it is necessary to blow nitrogen into the samples in the test tubes 100 or configure the filter sleeve column 1, the bottle cap on the test tube 100 is separated from the test tube 100 by the bottle cap clamping mechanism 22.

[0102] See Figure 1 and Figure 2, the bottle cap clamping mechanism 22 includes a lifting assembly 221, a rotating assembly 222, and a first clamping member 223. The first clamping member 223 is located above the bottle cap recycling member 211. The lifting assembly 221 is connected to the rotating assembly 222. The lifting assembly 221 can be a lead screw slide module, a linear motor, or a cylinder. The rotating assembly 222 is connected to the first clamping member 223. The first clamping member 223 is used to clamp the bottle cap or the filter sleeve column 1. The rotating assembly 222 is used to drive the first clamping member 223 to rotate. The lifting assembly 221 is used to drive the rotating assembly 222 to lift and lower, so that the first clamping member 223 approaches or moves away from the test tube 100.

[0103] See Figure 1 and Figure 2 , the bottle body clamping mechanism 23 includes a translation assembly 231, a support base 232, a second clamping member 233, and a sleeve column placement position 234. The translation assembly 231 can be a lead screw slide module, a linear motor, or a cylinder, etc. The support base 232 is arranged on the translation assembly 231. The second clamping member 233 and the sleeve column placement position 234 are arranged on the support base 232. The second clamping member 233 is used to clamp the test tube 100. The sleeve column placement position 234 is used to place the filter sleeve column 1. The sleeve column placement position 234 is provided with a convex block whose shape matches the opening shape of the filter sleeve column 1. The filter sleeve column 1 can be inserted downward with the opening on the convex block. The translation assembly 231 is used to drive the second clamping member 233 or the sleeve column placement position 234 to move below the first clamping member 223. The first clamping member 223 is used to clamp the filter sleeve column 1 and configure the filter sleeve column 1 at the opening of the test tube 100.

[0104] See Figure 1 and Figure 2 , when it is necessary to separate the bottle cap from the test tube 100, the handling mechanism 6 places the test tube 100 with the bottle cap on the second clamping member 233. The second clamping member 233 clamps and fixes the test tube 100. The translation assembly 231 moves the support base 232, so that the second clamping member 233 moves below the first clamping member 223. The lifting assembly 221 drives the rotating assembly 222 and the first clamping member 223 to descend, so that the first clamping member 223 can clamp and fix the bottle cap. The rotating assembly 222 then drives the first clamping member 223 to rotate. The lifting assembly 221 slowly rises along with the rotation of the rotating assembly 222, so that the bottle cap is separated from the test tube 100. The translation assembly 231 drives the test tube 100 away from the first clamping member 223, so that the bottle cap recycling member 211 can be aligned with the first clamping member 223 above. The first clamping member 223 releases the bottle cap, and the bottle cap falls into the bottle cap recycling member 211.

[0105] See Figure 1 and Figure 2, when it is necessary to configure the filter sleeve column 1 on the test tube 100, the handling mechanism 6 places the test tube 100 on the second clamping member 233. The second clamping member 233 clamps and fixes the test tube 100. The translation assembly 231 moves the support seat 232 so that the sleeve column placement position 234 is below the first clamping member 223. The lifting assembly 221 drives the rotating assembly 222 and the first clamping member 223 to descend, so that the first clamping member 223 can clamp the filter sleeve column 1. After the first clamping member 223 clamps the filter sleeve column 1, it rises. The translation assembly 231 moves the support seat 232 so that the second clamping member 233 moves to below the first clamping member 223. The lifting assembly 221 drives the rotating assembly 222 and the first clamping member 223 to descend, so that the filter sleeve column 1 is docked with the opening of the test tube 100. Among them, when the filter sleeve column 1 and the test tube 100 are in interference fit, the lifting assembly 221 drives the filter sleeve column 1 to descend so that the filter sleeve column 1 can be inserted on the test tube 100 for docking; when the filter sleeve column 1 and the test tube 100 are screwed together, the lifting assembly 221 drives the filter sleeve column 1 to descend, and the rotating assembly 222 drives the filter sleeve column 1 to rotate, so that the filter sleeve column 1 is screwed together with the test tube 100.

[0106] It can be understood that the switch cover module 2 can also adopt other existing implementation methods. For example, it can be changed to rotate the bottle body clamping mechanism 23 to tighten or loosen the bottle cap or the filter sleeve column 1, or it can be changed to rotate the bottle cap clamping mechanism 22 and the bottle body clamping mechanism 23 simultaneously to tighten or loosen the bottle cap or the filter sleeve column 1. This is not limited here.

[0107] See Figure 1 and Figure 4, the centrifugal transfer module 4 includes a horizontal rotor 41, a plurality of hanging baskets 42 and a centrifugal rotation mechanism. The centrifugal rotation mechanism is connected to the horizontal rotor 41 and is used to drive the horizontal rotor 41 to rotate. The plurality of hanging baskets 42 are evenly arranged on the horizontal rotor 41, and the hanging baskets 42 are used to place the test tubes 100. The centrifugal rotation mechanism can drive the horizontal rotor 41 to rotate, thereby driving the hanging baskets 42 to rotate, so that the test tubes 100 in the hanging baskets 42 perform centrifugal motion. The horizontal rotor 41 includes a square base plate 411 and two support rods 412 arranged at each vertex of the base plate 411. The centrifugal rotation mechanism is fixedly connected to the base plate 411, and the two support rods 412 at each vertex extend outward along two sides of the base plate 411. In some embodiments, the hanging basket 42 can be arranged between two parallel support rods 412 at adjacent vertices. In some embodiments, the hanging basket 42 can be arranged between the two support rods 412 at any vertex. The support rods 412 can increase the distance between the test tubes 100 in the hanging baskets 42 and the centrifugal rotation mechanism, improving the centrifugation effect of the samples in the test tubes 100. Among them, the base plate 411 can be square or rectangular, and the two support rods 412 at any vertex are perpendicular to each other. Each hanging basket 42 can hold at least one test tube 100, and the centrifugal transfer module 4 can perform centrifugation on multiple test tubes 100 at the same time, improving the experimental throughput.

[0108] See Figure 1 and Figure 10 , before the test tube 100 is placed on the workbench 400, an identification can be manually pasted on the outer side of the test tube 100 or marked by the marking machine 300. The identification can be a character code, a two-dimensional code or a bar code, etc., so as to serve as the identity information of the test tube 100. The sample processing system further includes a code scanning module 10. The code scanning module 10 includes a code scanning gun 101, a test tube holder and a code scanning rotation mechanism. The test tube holder is used to place the test tube 100. The code scanning rotation mechanism is connected to the test tube holder and is used to drive the test tube holder to rotate. The code scanning gun 101 is used to scan the test tube 100. When it is necessary to identify the identity information of the test tube 100, the test tube holder can be driven to rotate by the code scanning rotation mechanism with the code scanning gun 101 stationary, so that the test tube holder rotates self, and the code scanning gun 101 can scan the information on the outer side of the test tube 100, thereby identifying the identity information of the test tube 100.

[0109] See Figure 1 and Figure 10, the test tube holder includes a first test tube holder 102 and a second test tube holder 103. The first test tube holder 102 can hold at least one test tube 100, and the second test tube holder 103 can hold at least one test tube 100. In some embodiments, the code scanning and rotating mechanism includes a driving motor 104, a first gear 105 and a second gear 106. The first test tube holder 102 is fixedly connected to the first gear 105, the second test tube holder 103 is fixedly connected to the second gear 106, the first gear 105 meshes with the second gear 106, and the driving motor 104 is drivingly connected to the first gear 105 or the second gear 106. The driving motor 104 is used to drive the first gear 105 or the second gear 106 to rotate, so as to drive the first test tube holder 102 and the second test tube holder 103 to rotate, so that the test tubes 100 in the first test tube holder 102 and the test tubes 100 in the second test tube holder 103 can rotate, and the barcode scanner 101 can scan the identifiers on the outer side surfaces of the test tubes 100. In some embodiments, the code scanning and rotating mechanism includes a driving motor 104, a first synchronous pulley, a second synchronous pulley and a synchronous belt. The first test tube holder 102 is fixedly connected to the first synchronous pulley, the second test tube holder 103 is fixedly connected to the second synchronous pulley, the synchronous belt is wound around the first synchronous pulley and the second synchronous pulley, and the driving motor 104 is drivingly connected to the first synchronous pulley or the second synchronous pulley. The driving motor 104 is used to drive the first synchronous pulley or the second synchronous pulley to rotate, so as to drive the first test tube holder 102 and the second test tube holder 103 to rotate, so that the test tubes 100 in the first test tube holder 102 and the test tubes 100 in the second test tube holder 103 can rotate, and the barcode scanner 101 can scan the identifiers on the outer side surfaces of the test tubes 100. Among them, there can be two barcode scanners 101, and one barcode scanner 101 is provided corresponding to one test tube holder. The barcode scanner 101 can also be used to scan the liquid collection bottle 503. Correspondingly, the test tube holder can also be used to place the liquid collection bottle 503.

[0110] See Figure 1, the sample processing system further includes a loading and unloading module 200. The loading and unloading module 200 is used to place the test tube 100 and / or the filter column 1. The test tube 100 can be temporarily placed in the loading and unloading module 200 before or after adding the sample. The filter column 1 can also be placed in the loading and unloading module 200 before being equipped to the switch cover module 2. The loading and unloading module 200 is provided with a plurality of material placement positions, and each material placement position is provided with a positioning mechanism and / or a sensing mechanism. The positioning mechanism is used to position the tray carrying the test tube 100 and / or the filter column 1 to ensure that the test tube 100 and the filter column 1 can be stably stored in the material placement position. The positioning mechanism can include, but is not limited to, at least one of a positioning pin, a positioning bump, a positioning groove, a limiting strip, a magnetic member (such as a permanent magnet, an electromagnet, etc.). The sensing mechanism is used to sense the usage state of the material placement position, such as whether there is a vacant position on the material placement position, and whether the test tube 100 or the filter column 1 is on the material placement position. Optionally, the loading and unloading module 200 can also be used to place the liquid collection bottle 503, and the liquid collection bottle 503 is used to collect the filtrate obtained by filtering through the filtering module 5.

[0111] See Figures 11 - 14 , the filter column 1 includes a first tube body 11, a second tube body 12 and a connecting member 13. The first tube body 11 is communicated with the second tube body 12. Both the first tube body 11 and the second tube body 12 have inner cavities, and the inner cavities of the two are communicated. One end of the first tube body 11 away from the second tube body 12 is provided with a first opening 111, and one end of the second tube body 12 away from the first tube body 11 is provided with a second opening 121; the connecting member 13 is arranged at one end of the first tube body 11 close to the first opening 111, and the connecting member 13 is used to connect the first tube body 11 with the test tube 100 loaded with the sample. A liquid flow channel for communicating the first tube body 11 and the test tube 100 is arranged in the connecting member 13. The inner diameter of the first tube body 11 is larger than the inner diameter of the second tube body 12, which is convenient for the first tube body 11 to hold more liquid samples. The smaller inner diameter of the second tube body 12 can limit the flow rate of the liquid sample when flowing out from the second opening 121. This filter column 1 can be used by arranging a filter element in the inner cavity and / or connecting a filter head 504 at the second opening 121.

[0112] See Figures 11 - 14, the liquid flow channel includes a first liquid flow channel 131 and a second liquid flow channel 132 that are connected and communicate with each other. The first liquid flow channel 131 is on the side close to the test tube 100, and the second liquid flow channel 132 is on the side close to the first tube body 11. The inner diameter of the first liquid flow channel 131 is larger than that of the second liquid flow channel 132, and the connection between the first liquid flow channel 131 and the second liquid flow channel 132 is smoothly transition-connected, so that a diversion surface is formed at the connection of the two liquid flow channels, facilitating the more rapid inflow of the liquid sample in the test tube 100 into the first tube body 11. The axes of the first liquid flow channel 131, the second liquid flow channel 132, the first tube body 11, and the second tube body 12 are all collinear. With such a setting, it is convenient for the liquid sample to transition from the test tube 100 to the filter sleeve column 1 without obstruction.

[0113] See Figures 11 - 14 , in some embodiments, the connector 13 is in interference fit with the test tube 100. When the switch cover module 2 configures the test tube 100 and the filter sleeve column 1, the first clamping member 223 can clamp the filter sleeve column 1 and press down to insert the filter sleeve column 1 onto the test tube 100.

[0114] In some embodiments, the inner wall of one end of the connector 13 connected to the test tube 100 is provided with internal threads, and the outer wall of the test tube 100 near the opening is provided with external threads. The internal threads and the external threads are in mating connection so that the filter sleeve column 1 is configured at the opening of the test tube 100. When the first clamping member 223 clamps the filter sleeve column 1 and docks it with the test tube 100, the rotating assembly 222 needs to drive the filter sleeve column 1 to rotate so that the filter sleeve column 1 is screwed and fixed to the test tube 100.

[0115] Among them, the connection between the connector 13 and the first tube body 11 can be an interference fit or a threaded connection, which is not limited herein. Preferably, one end of the connector 13 is in threaded connection with the test tube 100, and the other end is in interference fit with the first tube body 11.

[0116] See Figures 11 - 14 , the filter sleeve column 1 further includes a plug 14. The plug 14 is detachably connected to one end of the second tube body 12 away from the first tube body 11. The plug 14 is used to block the second opening 121 before filtration to prevent the liquid sample in the inner cavity from flowing out of the second opening 121 in advance. Specifically, the plug 14 can be screwed to the second tube body 12 through threads, the plug 14 can also be fixed to the second tube body 12 through interference fit, and the plug 14 can also be magnetically adsorbed to the second tube body 12, which is not limited herein. When the flipping module 3 flips the test tube 100 configured with the filter sleeve column 1, the filter sleeve column 1 is located below the test tube 100, and the second opening 121 faces downward. When it is necessary to discharge the sample in the filter sleeve column 1, the plug 14 can be removed from the second opening 121, and the sample can be discharged from the second opening 121.

[0117] In some embodiments, the filter sleeve column 1 further includes a filter element, which is located in the first tube body 11 and is arranged near one end of the second tube body 12. The filter element is used to filter the sample in the first tube body 11. With such an arrangement, the filtration of the liquid sample can be completed by the built-in filter element, without the need for an external filter head 504 to occupy additional space, and the operation of the external filter head 504 can be eliminated to simplify the process flow. Among them, the specific structure and composition of the filter element are not limited. For example, the filter element can be composed of diatomaceous earth or silica gel, etc.

[0118] See Figure 15 and Figure 16 , the filtration module 5 includes a support frame 51 and a filtration module 52, and the filtration module 52 is arranged on the support frame 51; wherein, the filtration module 52 includes a filter jaw assembly and a pressure regulating mechanism. The filter jaw assembly includes a first driving mechanism 521 and a filter jaw 522 that is drivingly connected to the first driving mechanism 521. The first driving mechanism 521 is arranged on the support frame 51, and the first driving mechanism 521 is used to drive the filter jaw 522 to clamp the filter sleeve column 1. The pressure regulating mechanism is used to connect the filter sleeve column 1 and regulate the air pressure in the filter sleeve column 1 to filter the sample in the filter sleeve column 1.

[0119] Specifically, after the connecting piece 13 of the filter sleeve column 1 together with the test tube 100 is removed from the first tube body 11, the filter jaw 522 clamps the filter sleeve column 1, and the pressure regulating mechanism can be docked and communicated with the first opening 111 to facilitate regulating the air pressure in the filter sleeve column 1 to filter the sample in the filter sleeve column 1. When it is necessary to filter the liquid sample in the filter sleeve column 1, a filter element can be arranged inside the filter sleeve column 1 and / or a filter head 504 can be arranged outside. The pressure regulating mechanism regulates the air pressure in the filter sleeve column 1, so that the liquid sample in the filter sleeve column 1 passes through the filter element inside the filter sleeve column 1 and / or the filter head 504 outside under the action of the air pressure, thereby realizing the filtration of the sample in the filter sleeve column 1.

[0120] In the embodiment of the present application, the specific structure of the first driving mechanism 521 is not limited. For example, the first driving mechanism 521 can be a driving mechanism such as a motor or a cylinder. The filtering gripper 522 can be two or more clamping blocks, and each clamping block has a clamping surface for clamping the filtering sleeve column 1. The clamping surface can be a plane, a curved surface, or a combination of a plane and a plane, a plane and a curved surface, a curved surface and a curved surface, etc., which is not limited herein. An elastic member (such as a rubber pad, a silica gel pad, etc.) and / or an anti-slip member (such as granular, toothed, etc.) can also be provided on the clamping surface. By providing the elastic member, the rigid collision between the filtering gripper 522 and the filtering sleeve column 1 can be avoided, which plays a protective role for the filtering sleeve column 1; by providing the anti-slip member, the friction between the filtering gripper 522 and the filtering sleeve column 1 can be increased, avoiding the dropping of the filtering sleeve column 1. The first driving mechanism 521 is connected to each clamping block of the filtering gripper 522 to drive each clamping block to approach or separate from each other. The support frame 51 supports the filtering module 52. The support frame 51 can be a flat plate or a gantry, etc., which is not limited herein.

[0121] The filtering module 5 clamps the filtering sleeve column 1 by setting the filtering gripper 522. When it is necessary to filter the liquid sample in the filtering sleeve column 1, the air pressure in the filtering sleeve column 1 is adjusted through the pressure regulating mechanism, so that the liquid sample in its inner cavity can be filtered through the internal filter element in the tube body and / or the external filter head 504, realizing the automation of the filtering operation, which not only reduces the workload of the experimental personnel, but also improves the filtering efficiency. In addition, it also avoids the direct contact of the experimental personnel with the liquid sample, ensuring the health and safety of the experimental personnel.

[0122] The filtering module 52 further includes an adapter 523. The adapter 523 is arranged on the support frame 51 and above the filtering gripper 522. One end of the adapter 523 is connected to the pressure regulating mechanism, and the other end of the adapter 523 is used for sealing connection with the filtering sleeve column 1. The adapter 523 has a first channel for connecting the filtering sleeve column 1 and the pressure regulating mechanism. Among them, the first channel is opened through the opposite ends of the adapter 523. One end of the first channel is connected to the pressure regulating mechanism, and the other end is connected to the filtering sleeve column 1. The adapter 523 and the filtering sleeve column 1 can be sealedly connected by means of elastic abutment, interference connection, etc. When the filtering gripper 522 clamps the filtering sleeve column 1, in order to ensure that the pressure regulating mechanism can adjust the air pressure in the filtering sleeve column 1, the adapter 523 can be docked with the first opening 111 of the filtering sleeve column 1 to make the adapter 523 and the filtering sleeve column 1 sealedly connected. When the pressure regulating mechanism adjusts the air pressure in the filtering sleeve column 1, the gas will not leak from the first opening 111.

[0123] In some embodiments, the pressure regulating mechanism includes a positive pressure component. One end of the positive pressure component is communicated with the first channel, and the other end is communicated with a gas source. The positive pressure component is used to pressurize the filter sleeve column 1. By pressurizing the filter sleeve column 1 through the positive pressure component, the air pressure in the filter sleeve column 1 is increased, so that the liquid sample in the filter sleeve column 1 can flow out under the action of pressure. Among them, the gas source communicated with the positive pressure component can be an inert gas such as nitrogen or helium that does not react with the liquid sample.

[0124] In some embodiments, the pressure regulating mechanism further includes a pressure relief component. One end of the pressure relief component is communicated with the first channel, and the other end is communicated with the atmospheric environment. The pressure relief component is used to relieve the pressure of the filter sleeve column 1 when the adapter 523 is connected to the filter sleeve column 1. Specifically, during the docking process of the adapter 523 and the filter sleeve column 1, the adapter 523 gradually extends into the filter sleeve column 1, compressing the gas in the inner cavity of the filter sleeve column 1 and increasing the air pressure in the inner cavity. To prevent the liquid sample from flowing out in advance before the filtration preparation is completed due to the increase in the inner cavity air pressure, the pressure relief component is opened while the adapter 523 and the filter sleeve column 1 are docking. By relieving the pressure of the inner cavity through the pressure relief component, the air pressure in the inner cavity is always at the level of the external environmental air pressure when the adapter 523 and the filter sleeve column 1 are docking.

[0125] In some embodiments, the pressure regulating mechanism further includes a negative pressure component. The negative pressure component is communicated with the first channel and is used to create a negative pressure in the filter sleeve column 1. When the adapter 523 is connected to the filter sleeve column 1, the pressure relief component keeps the air pressure in the inner cavity at the level of the external environmental air pressure. After the adapter 523 is completely and tightly connected to the filter sleeve column 1, the pressure relief component is closed and the negative pressure component is opened, and the negative pressure component creates a negative pressure in the inner cavity.

[0126] In an example, when the plug 14 is not provided in the filter sleeve column 1, after the negative pressure component creates a negative pressure in the inner cavity, the gas in the external environment can enter the inner cavity from the second opening 121, and the gas pushes the liquid in the inner cavity upward, causing the liquid in the inner cavity to rise. At this time, by creating a negative pressure through the negative pressure component, it is possible to prevent the liquid sample in the inner cavity from flowing out of the filter sleeve column 1 in advance due to the action of gravity. When the liquid rises to an appropriate height or the filtration preparation is completed, the negative pressure component is closed, and the positive pressure component is started to pressurize the inner cavity. The liquid in the inner cavity flows out of the filter sleeve column 1 under the action of air pressure to realize the filtration operation of the liquid in the filter sleeve column 1.

[0127] In another example, when a plug 14 is provided at the end of the filter sleeve column 1, by providing a negative pressure assembly to create a negative pressure in the inner cavity before unloading the plug 14, it is possible to prevent the liquid in the inner cavity from splashing or dripping when unloading the plug 14, avoiding waste of liquid samples and contamination of the experimental environment. After the plug 14 is unloaded, the negative pressure assembly is closed, and the positive pressure assembly is activated to pressurize the inner cavity, and the liquid in the inner cavity flows out of the filter sleeve column 1 under the action of air pressure to achieve the filtration operation of the liquid in the filter sleeve column 1.

[0128] Among them, the negative pressure assembly may include a vacuum generator, a diaphragm pump or a piston pump. Further, the negative pressure assembly may further include a pressure regulating valve and a throttle valve, which are used in cooperation with the vacuum generator, the diaphragm pump or the piston pump. The pressure value in the filter sleeve column 1 can be adjusted through the pressure regulating valve, and the gas flow rate can be adjusted through the throttle valve. In one example, the negative pressure assembly includes a vacuum generator, a pressure regulating valve and a throttle valve connected in sequence, wherein the throttle valve is connected to the first channel of the adapter 523. It can be understood that the connection sequence of the pressure regulating valve and the throttle valve can be reversed.

[0129] See Figure 18 , in some embodiments, the pressure relief assembly includes a first switching valve 525. One end of the first switching valve 525 is communicated with the first channel, and the other end of the first switching valve 525 is communicated with the atmospheric environment 800. During the docking process of the adapter 523 and the filter sleeve column 1, the first switching valve 525 is opened, and the gas in the filter sleeve column 1 will flow through the first channel to the first switching valve 525 due to being squeezed, and then be discharged from the first switching valve 525 to the atmospheric environment 800 to make the air pressure in the filter sleeve column 1 and the atmospheric pressure balanced. When the docking of the adapter 523 and the filter sleeve column 1 is completed, the first switching valve 525 is closed. Among them, the first switching valve 525 can be an electromagnetic valve, a ball valve, a butterfly valve, a gate valve, a globe valve, etc., which is not limited herein. The pressure regulating mechanism further includes a digital display 529, which is communicated with the first channel, and the digital display 529 is used to display the air pressure in the filter sleeve column 1, facilitating the experimenter to timely and intuitively understand the air pressure in the filter sleeve column 1.

[0130] See Figure 18, in some embodiments, the positive pressure assembly includes a second switching valve 526 and a proportional valve 527. One end of the second switching valve 526 is communicated with the first channel, the other end of the second switching valve 526 is communicated with one end of the proportional valve 27, and the other end of the proportional valve 527 is communicated with a nitrogen output source 528. When it is necessary for the positive pressure assembly to pressurize the inner cavity, the second switching valve 526 is opened, the proportional valve 527 is opened, and the nitrogen output source 528 passes a certain amount of nitrogen into the inner cavity through the proportional valve 527 and the second switching valve 526, so that the air pressure in the inner cavity becomes larger, and then the liquid in the inner cavity is extruded out of the filter sleeve column 1. Among them, the proportional valve 527 can be a flow proportional valve, which can adjust the nitrogen flow rate passing through according to the volume of the filter sleeve column 1, save nitrogen and reduce costs while ensuring that the liquid in the inner cavity can be flushed out. The proportional valve 527 can also be a pneumatic proportional valve, which can control the air pressure input into the filter sleeve column 1, so as to adjust the flow rate of the liquid during filtration. The second switching valve 526 is the same as or similar to the first switching valve 525, and can also be an electromagnetic valve, a ball valve, a butterfly valve, a gate valve, a globe valve, etc., which is not limited here.

[0131] The filtration module 52 further includes a second liquid adding module. One end of the second liquid adding module is communicated with the solvent bottle, the other end of the second liquid adding module is communicated with the adapter 523, and the second liquid adding module is used to convey a second target liquid into the filter sleeve column 1. The adapter 523 further has a second channel for communicating the filter sleeve column 1 with the second liquid adding mechanism, and the second channel and the first channel are independent of each other.

[0132] In one example, when using the second liquid adding module to convey other liquids into the filter sleeve column 1, the filter gripper 522 grips the filter sleeve column 1. After the adapter 523 is successfully docked with the filter sleeve column 1, the second liquid adding module is started to inject the liquid into the filter sleeve column 1. Then, the negative pressure assembly is started to form a negative pressure in the filter sleeve column 1, the plug 14 is unloaded, and then the positive pressure assembly is started to filter the liquid sample in the filter sleeve column 1.

[0133] In another example, if it is necessary to filter the liquid sample in the filter sleeve column 1 multiple times to avoid residue of the liquid sample, after one filtration is completed, a specified liquid can be injected into the filter sleeve column 1 by using the second liquid adding module, and the filtration can be performed again, and so on until the filtration is completed.

[0134] Among them, the specific structure of the second liquid adding module is not limited, and a common liquid adding mechanism on the current market can be adopted. The structure of the second liquid adding module can be the same as or similar to that of the first liquid adding module 7. In one example, the second liquid adding module and the first liquid adding module 7 can be the same module. In one example, the negative pressure component and the second liquid adding module can be the same module, and a plunger pump is used to directly suck negative pressure or liquid. In another example, the negative pressure component, the second liquid adding module, and the first liquid adding module 7 can be the same module. In all of the above three cases, both the system structure can be simplified and the equipment cost can be reduced.

[0135] The filtering module 5 further includes a second lifting mechanism 53. The second lifting mechanism 53 is arranged on the support frame 51. The filtering module 52 is drivingly connected to the second lifting mechanism 53. The second lifting mechanism 53 is used to drive the filtering module 52 to lift, so as to ensure that the filtering jaw 522 can approach or move away from the liquid collecting bottle 503, so that when the filtering jaw 522 drives the filtering sleeve column 1 to approach the liquid collecting bottle 503, the filtered liquid can accurately flow into the liquid collecting bottle 503. The specific structure of the second lifting mechanism 53 is not limited. For example, the second lifting mechanism 53 can be a combination of a screw motor and a guiding member (such as a guide rail, a guide rod, etc.).

[0136] The filtering module 52 further includes a third lifting mechanism 524. The third lifting mechanism 524 is arranged on the support frame 51. The adapter 523 is drivingly connected to the third lifting mechanism 524. The third lifting mechanism 524 is used to drive the adapter 523 to approach or move away from the filtering jaw 522. Specifically, the third lifting mechanism 524 can drive the adapter 523 to lift above the filtering jaw 522, so that after the adapter 523 approaches the filtering jaw 522, it can be combined with the filtering sleeve column 1 on the filtering jaw 522. Among them, the specific structure of the third lifting mechanism 524 is not limited. For example, the third lifting mechanism 524 can be a combination of a screw motor and a guiding member (such as a guide rail, a guide rod, etc.).

[0137] See Figures 15 - 17 , the filtering module 5 further includes a base 54 and a placement rack 55 located on the base 54. The placement rack 55 is provided with at least one first placement position 551. The first placement position 551 is used to place the liquid collecting bottle 503, and the liquid collecting bottle 503 is used to receive the filtered liquid.

[0138] The filtering module 5 further includes a second translation mechanism 56 and / or a third translation mechanism 57. The base 54 is disposed on the second translation mechanism 56, and the second translation mechanism 56 is configured to drive the base 54 to move in a fourth direction, so that the liquid collection bottle 503 on the placement rack 55 approaches or moves away from the filtering jaw 522. The second translation mechanism 56 may be disposed on the support frame 51 or the workbench 400. When the base 54 moves in the fourth direction, the placement rack 55 also moves in the fourth direction, and the liquid collection bottle 503 also moves in the fourth direction, so that the second translation mechanism 56 can control the liquid collection bottle 503 on the placement rack 55 to approach or move away from the filtering jaw 522.

[0139] See Figure 15 and Figure 16 , the third translation mechanism 57 is disposed on the support frame 51 and connected to the filtering module 52. The third translation mechanism 57 is configured to drive the filtering module 52 to move in a fifth direction, so that the filtering jaw 522 approaches or moves away from the liquid collection bottle 503. Wherein, the fourth direction and the fifth direction are parallel or perpendicular. Wherein, when the filtering module 5 includes the second translation mechanism 56 and the third translation mechanism 57, the fourth direction and the fifth direction are parallel or perpendicular. When the fourth direction and the fifth direction are perpendicular, the fourth direction may be Figure 1 the y-axis direction shown, and the fifth direction may be Figure 1 the x-axis direction shown. The third lifting mechanism 524 drives the adapter 523 to move in the Figure 1 z-axis direction shown, and the second lifting mechanism 53 drives the filtering module 52 to also move in the z-axis direction. When the fourth direction and the fifth direction are parallel, both the fourth direction and the fifth direction may be the x-axis direction, or both the fourth direction and the fifth direction may be the y-axis direction. The structures of the second translation mechanism 56 and the third translation mechanism 57 may be the same or similar, and their specific structures are not limited. For example, both the second translation mechanism 56 and the third translation mechanism 57 are a combination of a screw motor and a guiding member (such as a guide rail, a guide rod, etc.).

[0140] The filtering module 5 further includes a fixed clamping assembly 58. The fixed clamping assembly 58 is disposed on the base 54. When the base 54 moves in the fourth direction, the fixed clamping assembly 58 also moves in the fourth direction accordingly. The fixed clamping assembly 58 includes a second driving mechanism 581 and a fixed jaw 582 drivingly connected to the second driving mechanism 581. The second driving mechanism 581 can drive the fixed jaw 582 to close or open, so that the fixed jaw 582 can clamp and fix the filter sleeve column 1, or release the filter sleeve column 1 being clamped. The specific structure of the second driving mechanism 581 is not limited. For example, the second driving mechanism 581 can be a driving mechanism such as a motor or a cylinder. Among them, the filter sleeve column 1 can be moved to the fixed jaw 582 by the handling mechanism 6, and the fixed jaw 582 clamps the filter sleeve column 1. The fixed clamping assembly 58 cooperating with the second translation mechanism 56 can send the filter sleeve column 1 to the filter jaw 522. The structure of the fixed jaw 582 can be the same as or similar to that of the filter jaw 522, which is not limited herein. In one example, when it is inconvenient for the filter jaw 522 to directly clamp the filter sleeve column 1, by setting the fixed clamping assembly 58, the filter sleeve column 1 can be first fixed at the fixed jaw 582, and then the filter jaw 522 clamps the filter sleeve column 1. In another example, the fixed jaw 582 cooperates with the filter jaw 522 or the handling mechanism 6 to separate the test tube 100 and the connector 13 from the first tube body 11, and then the filter jaw 522 clamps the filter sleeve column 1.

[0141] It can be understood that it can be achieved by the cooperation of the fixed jaw 582 with the filter jaw 522 or the handling mechanism 6 to separate the test tube 100 and the connector 13 from the first tube body 11, or it can also be achieved by using the switch cover module 2 to separate the test tube 100 and the connector 13 from the first tube body 11, which is not limited herein.

[0142] The filtering module 5 further includes an unloading member 501. The unloading member 501 is located below the filter jaw 522. The unloading member 501 is used to separate the plug 14 from the second tube body 12. If the plug 14 and the second tube body 12 are screwed together, the unloading member 501 clamps or holds the plug 14 fixed, the filter jaw 522 clamps the first tube body 11, and the filter jaw 522 drives the first tube body 11 to rotate or the unloading member 501 drives the plug 14 to rotate to separate the plug 14 from the second tube body 12. If the plug 14 and the second tube body 12 are fixed by interference fit or magnetic attraction, the unloading member 501 clamps or holds the plug 14 fixed, the filter jaw 522 clamps and fixes the first tube body 11, and the filter jaw 522 drives the first tube body 11 to rise or the unloading member 501 drives the plug 14 to descend to separate the plug 14 from the second tube body 12.

[0143] It is understandable that the filter sleeve column 1 can be provided with both a filter element and a plug 14, or only a filter element or a plug 14. When only the plug 14 is provided, the filter sleeve column 1 can be used in combination with the filter head 504. In addition, when the filter sleeve column 1 is provided with a filter element, it can also be used in combination with the filter head 504 to improve the filtering effect.

[0144] The placement rack 55 is further provided with at least one second placement position 552 for placing the filter head 504. After the unloading member 501 unloads the plug 14, the filter gripper 522 drives the filter sleeve column 1 to pick up the filter head 504. When no filter element is provided in the first tube body 11, after unloading the plug 14, the placement rack 55 is moved below the filter gripper 522 so that the second opening 121 is aligned with one of the filter heads 504. The second lifting mechanism 53 drives the filter gripper 522 to descend, and the filter sleeve column 1 on the filter gripper 522 descends accordingly until the bottom end of the second tube body 12 is stuck on the filter head 504, fixing the second tube body 12 and the filter head 504 together. Then, the second lifting mechanism 53 drives the filter sleeve column 1 and the filter head 504 to rise, moves the liquid collection bottle 503 below the filter head 504 or moves the filter head 504 above the liquid collection bottle 503, and the positive pressure assembly pressurizes the inner cavity so that the liquid sample in the inner cavity passes through the filter head 504 and falls into the liquid collection bottle 503. Among them, the arrangement positions of the first placement position 551 and the second placement position 552 are not limited, and both can be arranged in an array. The first placement position 551 and the second placement position 552 can be arranged in a cross pattern, so that the placement rack 55 has uniform load bearing; the first placement position 551 and the second placement position 552 can also be arranged in different regions. For example, the first placement position 551 is arranged on the left side of the placement rack 55, and the second placement position 552 is arranged on the right side of the placement rack 55, which is convenient for taking and placing materials.

[0145] The filter module 5 further includes a recycling assembly 59. The recycling assembly 59 is provided on the base 54 and moves with the movement of the base 54. The unloading member 501 is located above the recycling assembly 59, facilitating the directly falling of the unloaded plug 14 into the recycling assembly 59. The second translation mechanism 56 can drive the recycling assembly 59 to move below the filter gripper 522. The recycling assembly 59 can include, but is not limited to, a consumable recycling box 591, a waste liquid pool 592, a buffer box 593, etc. Among them, the consumable recycling box 591 is used to recycle experimental consumables such as test tubes 100, connectors 13, filter sleeve columns 1, filter heads 504, and plugs 14. The waste liquid pool 592 is used for the second liquid adding module to drain waste liquid. For example, the waste liquid for cleaning the pipeline when replacing the solvent is discharged to the waste liquid pool 592 through the adapter 523. The buffer box 593 is used to temporarily store the faulty filter sleeve column 1. For example, when the filter sleeve column 1 is blocked and cannot filter normally, by temporarily storing the faulty filter sleeve column 1, the experimental personnel can timely handle the fault or remove the liquid sample inside, avoiding waste of the liquid sample.

[0146] The filtration module 5 also includes a detector 502, which is arranged on the base 54. The detector 502 is used to detect whether the filter sleeve 1 has pierced the filter head 504. When it is necessary to filter the liquid sample in the filter sleeve 1, the unloader 501 separates the plug 14 from the second tube body 12, and the filter clamp 522 drives the filter sleeve 1 to pierce the filter head 504. Then, the detector 502 is used to detect whether the filter sleeve 1 has successfully pierced the filter head 504. If the filter sleeve 1 correctly pierces the filter head 504, the pressure regulating mechanism pressurizes the inner cavity so that the liquid sample in the inner cavity passes through the filter head 504 and falls into the liquid collection bottle 503; if the filter sleeve 1 does not pierce the filter head 504 or the filter head 504 is pierced crookedly, the filter head 504 is re-pierced or an alarm is issued to notify the experimenter to handle it. Among them, the detector 502 can include but is not limited to sensors (such as laser sensors, infrared sensors, etc.), cameras, etc.

[0147] In some embodiments, as Figure 15 and 16 As shown, there can be multiple filter modules 52, and the multiple filter modules 52 are arranged in a horizontal direction (such as Figure 1 The filter modules 52 are arranged in intervals on the support frame 51 (in the x-axis direction shown). Each filter module 52 can filter the sample within a filter cartridge 1. Multiple filter modules 52 can filter multiple filter cartridges 1 simultaneously, greatly increasing experimental throughput and further improving filtration efficiency. Furthermore, multiple fixed clamping assemblies 58 can be provided, and multiple fixed clamping jaws 582 can cooperate with multiple filter clamping jaws 522 to achieve synchronous transfer of multiple filter cartridges 1.

[0148] See also Figure 1 and Figure 19 To shorten the interaction time between functional modules and improve experimental efficiency, the lid opening and closing module 2, nitrogen blowing module 9, first liquid adding module 7, mixing module 8, flipping module 3, centrifugal transfer module 4, loading and unloading module 200, code scanning module 10, and filtration module 5 are arranged in sequence around the handling module 6. The loading and unloading module 200 is located near the interactive door on the outer cover to facilitate material interaction with the outside world.

[0149] See also Figure 1 The sample processing system further includes a marking machine 300, which can code the liquid collection bottle 503 and / or the test tube 100. The marking machine 300 can use laser marking to print a logo on the side of the liquid collection bottle 503 or the test tube 100. The specific structure of the marking machine 300 is not limited and can be referred to in the related art.

[0150] See also Figure 1, in some embodiments, the sample processing system further includes a transfer module 500, a robotic arm 600, and a material rack 700. The material rack 700 can store the liquid collection bottle 503 and / or the test tube 100. The robotic arm 600 is used to grasp the liquid collection bottle 503 or the test tube 100. The robotic arm 600 can grasp the liquid collection bottle 503 or the test tube 100 on the material rack 700 and move it to the labeling machine 300. Then, the labeling machine 300 prints an identifier on the liquid collection bottle 503 or the test tube 100. After that, the robotic arm 600 grasps the labeled liquid collection bottle 503 or test tube 100 and moves it to the transfer module 500. The transfer module 500 transports the labeled liquid collection bottle 503 or test tube 100 to the handling mechanism 6, and the handling mechanism 6 transports the labeled liquid collection bottle 503 or test tube 100 to the loading and unloading module 200 for storage.

[0151] In some embodiments, the sample processing system further includes a mobile robot for picking up and placing materials on the loading and unloading module 200, such as placing materials like the test tube 100, the filter sleeve column 1, the liquid collection bottle 503, the filter head 504, etc., or picking up the liquid collection bottle 503 containing the filtrate. By setting up the mobile robot, a fully automated process for the experiment can be achieved, reducing manual interference.

[0152] The solutions of the present application have been described in detail above with reference to the accompanying drawings. In the above embodiments, the descriptions of the various embodiments have their own emphases. For parts not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments. Those skilled in the art should also be aware that the actions and modules involved in the specification are not necessarily essential to the present application. Additionally, it can be understood that the steps in the method embodiments of the present application can be adjusted, combined, and deleted according to actual needs, and the modules in the device embodiments of the present application can be combined, divided, and deleted according to actual needs.

[0153] The various embodiments of the present application have been described above. The above description is exemplary and not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations are obvious to those of ordinary skill in the art in the technical field without departing from the scope and spirit of the described embodiments. The selection of the terms used herein is intended to best explain the principles of the embodiments, practical applications, or improvements to the technologies in the market, or to enable other ordinary skilled persons in the technical field to understand the disclosed embodiments.

Claims

1. A sample processing system, characterized in that, Comprising: Filter sleeve column; Switch cover module, which is used to configure the filter sleeve column for the opening of the test tube loaded with samples; Flipping module, which is used to flip the test tube configured with the filter sleeve column; Centrifugal transfer module, which is used to centrifuge the samples in the filter sleeve column after flipping; Filter module, which is used to filter the samples in the filter sleeve column; Handling mechanism, which is used to handle test tubes and / or the filter sleeve column between the switch cover module, the flipping module, the centrifugal transfer module and the filter module.

2. The sample processing system according to claim 1, wherein: The sample processing system further includes a first liquid adding module, which is used to add a first target liquid into the test tube loaded with samples; The first liquid adding module includes a liquid adding needle, a mounting seat, a liquid adding moving mechanism, a first control valve and a first driving pump; the mounting seat is respectively connected to the liquid adding moving mechanism and the liquid adding needle, and the liquid adding moving mechanism is used to drive the mounting seat to move so as to drive the liquid adding needle to move; the first control valve is respectively communicated with a solvent bottle, the liquid adding needle and the first driving pump, and the liquid adding needle is used to inject the first target liquid in the solvent bottle into the test tube loaded with samples; the handling mechanism is used to transfer the test tube after liquid adding is completed to the switch cover module.

3. The sample processing system according to claim 2, wherein: The sample processing system further includes a mixing module, which is used to mix the test tube loaded with samples and the first target liquid; The mixing module includes an oscillation mechanism and an oscillation clamping mechanism, the oscillation clamping mechanism is connected to the oscillation mechanism, the oscillation clamping mechanism is used to clamp the test tube, and the oscillation mechanism is used to drive the oscillation clamping mechanism to vibrate so as to drive the test tube to shake; the handling mechanism is used to transfer the test tube configured with the filter sleeve column to the mixing module, and after mixing is completed, transfer it to the flipping module.

4. The sample processing system according to claim 2, wherein: The sample processing system further includes a nitrogen blowing module, which is used to perform nitrogen blowing treatment on the samples in the test tube; The nitrogen blowing module includes a first lifting mechanism, a nitrogen blowing needle, a connecting seat, a first translation mechanism, a bracket and a heating component, the nitrogen blowing needle is fixedly arranged on the connecting seat, the connecting seat is provided with an air duct, and the air duct is respectively communicated with the nitrogen blowing needle and a nitrogen source; the first lifting mechanism is connected to the connecting seat, and the first lifting mechanism is used to drive the connecting seat to lift so as to drive the nitrogen blowing needle to lift; the bracket is arranged on the first translation mechanism and is located below the nitrogen blowing needle, and the bracket is used to place the test tube, and the first translation mechanism is used to drive the bracket to approach or move away from the nitrogen blowing needle; the heating component is arranged on the first translation mechanism, and the heating component is used to heat the test tube on the bracket.

5. The sample processing system according to claim 1, wherein: The handling mechanism includes a first moving mechanism, a second moving mechanism, a third moving mechanism, and a handling and clamping assembly; the second moving mechanism is disposed on the first moving mechanism, and the first moving mechanism is configured to drive the second moving mechanism to move along a first direction; the third moving mechanism is disposed on the second moving mechanism, and the second moving mechanism is configured to drive the third moving mechanism to move along a second direction; the handling and clamping assembly is disposed on the third moving mechanism, and the third moving mechanism is configured to drive the handling and clamping assembly to move along a third direction; wherein, the first direction, the second direction, and the third direction are perpendicular to each other pairwise, and the handling and clamping assembly is used for clamping test tubes and / or filter sleeve columns.

6. The sample processing system according to claim 5, wherein: The handling and clamping assembly includes at least two jaws arranged at intervals along the length direction of the third moving mechanism, wherein at least one of the jaws is fixedly connected to the third moving mechanism in the length direction of the third moving mechanism, and the remaining jaws are movably connected to the third moving mechanism in the length direction of the third moving mechanism.

7. The sample processing system according to claim 1, wherein: The switch cover module includes a bottle cap clamping mechanism and a bottle body clamping mechanism located below the bottle cap clamping mechanism. The bottle body clamping mechanism is used for clamping test tubes, and the bottle cap clamping mechanism is used for clamping bottle caps or filter sleeve columns. The bottle cap clamping mechanism includes a lifting assembly, a rotating assembly, and a first clamping member. The lifting assembly is connected to the rotating assembly, the rotating assembly is connected to the first clamping member, the first clamping member is used for clamping bottle caps or filter sleeve columns, the rotating assembly is used for driving the first clamping member to rotate, and the lifting assembly is used for driving the rotating assembly to lift and lower, so that the first clamping member approaches or moves away from the test tube. The bottle body clamping mechanism includes a translation assembly, a support base, a second clamping member, and a sleeve column placement position. The support base is disposed on the translation assembly, the second clamping member and the sleeve column placement position are disposed on the support base. The second clamping member is used for clamping test tubes, the sleeve column placement position is used for placing the filter sleeve columns, the translation assembly is used for driving the second clamping member or the sleeve column placement position to move below the first clamping member, and the first clamping member is used for clamping the filter sleeve column and disposing the filter sleeve column at the opening of the test tube.

8. The sample processing system according to claim 1, wherein: The centrifugal transfer module includes a horizontal rotor, a plurality of hanging baskets, and a centrifugal rotation mechanism; the centrifugal rotation mechanism is connected to the horizontal rotor, the centrifugal rotation mechanism is used for driving the horizontal rotor to rotate, and the plurality of hanging baskets are uniformly disposed on the horizontal rotor, and the hanging baskets are used for placing test tubes. The horizontal rotor includes a square base plate and two support rods provided at each vertex of the base plate. The two support rods at each vertex extend outward along two sides of the base plate. The hanging basket is disposed between two parallel support rods at adjacent vertices, or the hanging basket is disposed between two support rods at any vertex.

9. The sample processing system according to claim 1, characterized in that: The sample processing system further includes a barcode scanning module, which includes a barcode scanner, a test tube holder, and a barcode scanning rotation mechanism; the test tube holder is used for placing test tubes, the barcode scanning rotation mechanism is connected to the test tube holder, and the barcode scanning rotation mechanism is used to drive the test tube holder to rotate, and the barcode scanner is used to scan the test tubes.

10. The sample processing system according to claim 9, wherein: The test tube holder includes a first test tube holder and a second test tube holder; the barcode scanning rotation mechanism includes a driving motor, a first gear, and a second gear. The first test tube holder is fixedly connected to the first gear, the second test tube holder is fixedly connected to the second gear, the first gear meshes with the second gear, and the driving motor is drivingly connected to the first gear or the second gear. The driving motor is used to drive the first gear or the second gear to rotate, so as to drive the first test tube holder and the second test tube holder to rotate; or The barcode scanning rotation mechanism includes a driving motor, a first synchronous pulley, a second synchronous pulley, and a synchronous belt. The first test tube holder is fixedly connected to the first synchronous pulley, the second test tube holder is fixedly connected to the second synchronous pulley, the synchronous belt is wound around the first synchronous pulley and the second synchronous pulley, and the driving motor is drivingly connected to the first synchronous pulley or the second synchronous pulley. The driving motor is used to drive the first synchronous pulley or the second synchronous pulley to rotate, so as to drive the first test tube holder and the second test tube holder to rotate.

11. The sample processing system according to claim 1, wherein: The sample processing system further includes a loading and unloading module, which is used for placing test tubes and / or filter sleeve columns; The loading and unloading module is provided with a plurality of material placement positions, and each material placement position is provided with a positioning mechanism and / or a sensing mechanism. The positioning mechanism is used to position the tray carrying the test tube and / or the filter sleeve column, and the sensing mechanism is used to sense the usage state of the material placement position; the positioning mechanism includes at least one of a positioning pin, a limiting bar, and a magnetic part.

12. The sample processing system according to any one of claims 1-11, characterized in that: The filter sleeve column includes a first tube body, a second tube body, and a connecting piece. The first tube body is communicated with the second tube body. One end of the first tube body away from the second tube body is provided with a first opening, and one end of the second tube body away from the first tube body is provided with a second opening; the connecting piece is arranged at one end of the first tube body close to the first opening, and the connecting piece is used to connect the first tube body and the test tube loaded with the sample. A liquid flow channel for communicating the first tube body and the test tube is arranged in the connecting piece; Wherein, the inner diameter of the first tube body is larger than the inner diameter of the second tube body.

13. The sample processing system according to claim 12, wherein: The liquid flow channel includes a first liquid flow channel and a second liquid flow channel that are communicated. The first liquid flow channel is close to the test tube side, and the second liquid flow channel is close to the first tube body side; the inner diameter of the first liquid flow channel is larger than the inner diameter of the second liquid flow channel; The axes of the first liquid flow channel, the second liquid flow channel, the first tube body, and the second tube body are all collinear.

14. The sample processing system according to claim 12, wherein: The connecting piece is in interference fit with the test tube; or The inner wall of one end of the connecting piece connected to the test tube is provided with internal threads, and the outer wall of the test tube near the opening is provided with external threads. The internal threads are in mating connection with the external threads so that the filter sleeve column is arranged at the opening of the test tube.

15. The sample processing system according to claim 12, characterized in that: The filter sleeve column further includes a plug, which is detachably connected to one end of the second tube body away from the first tube body. The plug is used to block the second opening before filtration.

16. The sample processing system according to claim 12, wherein: The filter sleeve column further includes a filter element, which is arranged inside the first tube body and near one end of the second tube body. The filter element is used to filter the sample inside the first tube body.

17. The sample processing system according to claim 12, wherein: The filter module includes a support frame and a filter module group. The filter module group is arranged on the support frame. Among them, the filter module group includes a filter clamping jaw assembly and a pressure regulating mechanism. The filter clamping jaw assembly includes a first driving mechanism and a filter clamping jaw that is drivingly connected to the first driving mechanism. The first driving mechanism is arranged on the support frame, and the first driving mechanism is used to drive the filter clamping jaw to clamp the filter sleeve column. The pressure regulating mechanism is used to communicate with the filter sleeve column and adjust the air pressure inside the filter sleeve column to filter the sample inside the filter sleeve column.

18. The sample processing system according to claim 17, wherein: The filter module group further includes an adapter, which is arranged on the support frame and above the filter clamping jaw. One end of the adapter is connected to the pressure regulating mechanism, and the other end of the adapter is used for sealing connection with the filter sleeve column. The adapter has a first channel, and the first channel is used to communicate the filter sleeve column with the pressure regulating mechanism.

19. The sample processing system according to claim 18, wherein: The pressure regulating mechanism includes a positive pressure component and a pressure relief component. One end of the pressure relief component is communicated with the first channel, and the other end is communicated with the atmospheric environment. The pressure relief component is used to relieve the pressure of the filter sleeve column when the adapter is connected to the filter sleeve column. One end of the positive pressure component is communicated with the first channel, and the other end is communicated with a gas source. The positive pressure component is used to pressurize the inside of the filter sleeve column.

20. The sample processing system according to claim 19, wherein: The pressure regulating mechanism further includes a negative pressure component, which is communicated with the first channel. The negative pressure component is used to create a negative pressure inside the filter sleeve column.

21. The sample processing system according to claim 18, wherein: The filter module group further includes a second liquid adding module. One end of the second liquid adding module is communicated with a solvent bottle, and the other end is communicated with the adapter. The second liquid adding module is used to transport a second target liquid into the filter sleeve column. The adapter further has a second channel, and the second channel is used to communicate the filter sleeve column with the second liquid adding module.

22. The sample processing system according to claim 18, wherein: The filter module further includes a second lifting mechanism, which is arranged on the support frame. The filter module group is drivingly connected to the second lifting mechanism, and the second lifting mechanism is used to drive the filter module group to lift and lower. and / or The filter module group further includes a third lifting mechanism, which is arranged on the support frame. The adapter is drivingly connected to the third lifting mechanism, and the third lifting mechanism is used to drive the adapter to approach or move away from the filter clamping jaw.

23. The sample processing system according to claim 17, wherein: The filter module further includes a base and a placement rack located on the base. The placement rack is provided with at least one first placement position, and the first placement position is used to place a liquid collection bottle. The filtering module further includes a second translation mechanism and / or a third translation mechanism. The base is disposed on the second translation mechanism, and the second translation mechanism is configured to drive the base to move in a fourth direction so that the liquid collection bottle on the placement rack approaches or moves away from the filtering gripper. The third translation mechanism is disposed on the support frame and connected to the filtering module, and the third translation mechanism is configured to drive the filtering module to move in a fifth direction so that the filtering gripper approaches or moves away from the liquid collection bottle. Wherein, the fourth direction is parallel or perpendicular to the fifth direction.

24. The sample processing system according to claim 23, wherein: The filtering module further includes a fixed clamping assembly disposed on the base; The fixed clamping assembly includes a second driving mechanism and a fixed gripper drivingly connected to the second driving mechanism. The second driving mechanism is configured to drive the fixed gripper to clamp the filtering sleeve column, and the fixed gripper cooperates with the filtering gripper or the handling mechanism to separate the test tube and the connecting member from the first tube body.

25. The sample processing system according to claim 23, wherein: The filtering sleeve column further includes a plug detachably connected to an end of the second tube body remote from the first tube body, and the plug is configured to block the second opening before filtering; The filtering module further includes an unloading member located below the filtering gripper, and the unloading member is configured to separate the plug from the second tube body.

26. The sample processing system according to claim 25, wherein: The placement rack is further provided with at least one second placement position for placing a filter head. After the unloading member removes the plug, the filtering gripper drives the filtering sleeve column to pick up the filter head.

27. The sample processing system according to claim 26, wherein: The filtering module further includes a recovery assembly disposed on the base, and the unloading member is located above the recovery assembly; The filtering module further includes a detector disposed on the base, and the detector is configured to detect whether the filtering sleeve column picks up a filter head.

28. The sample processing system according to claim 23, wherein: The sample processing system further includes a marking machine for coding the liquid collection bottle and / or the test tube.

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