Chemiluminescence detection sample incubation detection platform

Abstract

The utility model discloses a chemiluminescence detection sample incubation detection platform. The device comprises a base, a sliding table, a reagent mounting frame and a transverse movement driving assembly. The sliding table is connected to the base in a sliding mode and driven by the transverse movement driving assembly. A reagent mounting rack is fixed at the top of the sliding table; the reagent mounting rack is provided with one or more reagent mounting grooves. A reagent strip limiting structure is arranged in the reagent mounting groove. The reagent strip limiting structure comprises a locking structure and an end limiting step. The end part limiting step is arranged at the end part of the bottom surface of the reagent mounting groove; the locking structure comprises a locking plunger and an elastic piece. The reagent mounting groove is designed to be of a transverse insertion type structure, and the end limiting step and the locking structure with the telescopic plunger are arranged on the reagent mounting groove, so that the position of a reagent strip can be restrained in all directions, and smooth chemiluminescence detection is ensured. Meanwhile, the telescopic plunger can make a sound when the reagent strip is inserted in place, and feedback is provided for workers.

Description

Technical Field

[0001] The utility model belongs to the technical field of sample detection, and in particular relates to a chemiluminescence detection sample incubation detection platform. Background Art

[0002] Single-dose chemiluminescence signature testing differs from traditional tube-based chemiluminescence testing solutions that use large-format bottles of reagents. Its reagents are individually packaged, and all necessary reagents and consumables are integrated into a single-dose reagent strip. Furthermore, single-dose chemiluminescence devices lack a fluidic system and require no maintenance, making them suitable for use in traditional point-of-care (POCT) scenarios while also expanding the scope of testable items.

[0003] Most existing single-person chemiluminescence detection instruments use a disc structure, and the position of the reagent strip is switched by the rotation of the disc. Its structure is less compact and the overall size of the instrument is larger. In addition, the positioning structure of the reagent strip in existing single-person chemiluminescence detection instruments is not effective, making it difficult to fully constrain the position of the reagent strip during the detection process. Summary of the Invention

[0004] The purpose of the utility model is to provide a chemiluminescence detection sample incubation detection platform.

[0005] The present invention provides a chemiluminescence detection sample incubation and detection platform, comprising a base, a slide, a reagent mounting rack, and a transverse drive assembly. The slide is slidably connected to the base and driven by the transverse drive assembly. A reagent mounting rack is fixed to the top of the slide; the reagent mounting rack is provided with one or more reagent mounting slots.

[0006] The reagent installation slot is provided with a reagent strip limiting structure. The reagent strip limiting structure includes a locking structure and an end limiting step. The end limiting step is provided at the end of the bottom surface of the reagent installation slot and is used to provide a limit for the reagent strip along the sliding direction of the slide. The locking structure includes a locking plunger and an elastic member. The elastic member is used to apply elastic force to the locking plunger, so that the locking plunger presses against the latching hole on the inserted reagent strip, completing the limiting constraint of the reagent strip.

[0007] Preferably, the slide also includes a guide rail and a guide rod. The guide rail and guide rod are parallel to each other and are fixed to the base. One side of the slide bottom is slidably connected to the guide rail via a slider. The other side of the slide bottom is slidably connected to the guide rod via a linear bearing.

[0008] Preferably, the transverse drive assembly includes a rail plate, a motor, and a roller. The rail plate is fixed to the base; the roller is rotatably connected to the slide, and the outer circumference is in rolling connection with the rail plate; the motor is fixed to the slide, and the output shaft is coaxially fixed to the roller.

[0009] Preferably, the apparatus further comprises a tip box; a tip box positioning groove is formed on the top surface of the slide. The tip box is placed in the tip box positioning groove. The end stop step in the reagent installation groove is located at the end of the reagent installation groove facing away from the tip box positioning groove.

[0010] Preferably, the tip box is provided with one or more rows of tip storage holes. Each row of tip storage holes includes tip storage holes corresponding one-to-one to each reagent installation slot. The corresponding tip storage holes are aligned with the reagent installation slots along the sliding direction of the slide.

[0011] Preferably, the multiple reagent installation slots on the reagent installation rack are arranged in sequence, and the arrangement direction is perpendicular to the sliding direction of the slide.

[0012] Preferably, the tops of the two side surfaces of the reagent installation slot are provided with limiting ridges; the limiting ridges are used to prevent the reagent strip in the reagent installation slot from moving upward.

[0013] Preferably, a limit installation hole is provided on the bottom surface of the reagent installation tank, and the locking structure is installed in the limit installation hole.

[0014] Preferably, the top of the locking plunger is spherical.

[0015] Preferably, the apparatus further comprises a heating assembly which is installed inside the reagent mounting rack or on the top of the slide for heating the reagent strip.

[0016] The beneficial effects of the utility model are:

[0017] 1. This utility model utilizes a horizontal insertion slot for the reagent strip, equipped with end-stop steps and a locking mechanism featuring a retractable plunger. This fully constrains the position of the reagent strip, ensuring smooth chemiluminescence testing. The retractable plunger also emits an audible sound when the strip is fully inserted, providing feedback to the operator and preventing the risk of the strip not being fully inserted.

[0018] 2. The present invention provides linear guidance for the reagent mounting rack through the coordinated guidance of guide rails and guide rods. At the same time, multiple reagent mounting slots are arranged side by side on the linearly movable reagent mounting rack, resulting in a highly compact structure, which helps to reduce the overall size of the chemiluminescence detection instrument and lower equipment costs.

[0019] 3. The tip box in this invention is placed in the tip box positioning groove on the top surface of the slide and can be removed at any time. This design not only facilitates the installation of tips, but also prevents the tip box from blocking the reagent strip from being inserted horizontally into the reagent installation slot, allowing the tip box to be tightly arranged on the side of the reagent installation rack. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0021] Figure 2 Schematic diagram of the relative positions of the reagent mounting rack, slide and transverse drive assembly in the present invention;

[0022] Figure 3 This is the first structural diagram of the pipetting module in the utility model;

[0023] Figure 4 This is the second structural diagram of the pipetting module in the present invention;

[0024] Figure markings: 1. Guide rail; 2. Guide rod; 3. Slide; 4. Reagent mounting rack; 4-1. Reagent mounting slot; 4-1-1. Limiting ridge; 4-2. Locking structure; 4-3. End limiting step; 5. Tip box; 5-1. Tip storage hole; 6. Transverse drive assembly; 6. Track plate; 7. Motor; 8. Roller; 9. Reagent strip; 10. Detection tube. DETAILED DESCRIPTION

[0025] The present invention will be further described below with reference to the accompanying drawings.

[0026] like Figure 1 As shown, a chemiluminescent sample incubation detection platform includes a base (not shown), guide rails 1, guide rods 2, a slide 3, a reagent mounting rack 4, a tip box 5, a heating assembly, and a transverse drive assembly. The mutually parallel guide rails 1 and guide rods 2 are fixed to the base and provide guidance and support for the slide 3 and reagent mounting rack 4. One side of the bottom of the slide 3 is slidably connected to the guide rail 1 via a slider. The other side of the bottom of the slide 3 is slidably connected to the guide rod 2 via a linear bearing.

[0027] like Figure 1 and Figure 2 As shown, the traverse drive assembly, used to drive the slide 3 back and forth, includes a track 6, a motor 7, and rollers 8. Track 6 is fixed to the base; rollers 8 are rotatably connected to the slide 3, with their outer circumferences rollingly connected to track 6. Motor 7 is fixed to the slide 3, with its output shaft coaxially fixed to rollers 8. The rotation of rollers 8 drives the slide 3 along track 6.

[0028] like Figure 3 and Figure 4As shown, a reagent mounting rack 4 is fixed on the top of the slide 3 and is provided with a tip box positioning groove. The tip box 5 is placed in the tip box positioning groove. The tip box positioning groove is used to provide horizontal limitation for the tip box 5. The tip box 5 is located on one side of the reagent mounting rack 4. The reagent mounting rack 4 is provided with a plurality of reagent mounting grooves 4-1 arranged in sequence along a direction perpendicular to the axis of the guide rod 2. Adjacent reagent mounting grooves 4-1 are separated by partitions. The reagent mounting groove 4-1 adopts a slot structure. The tops of both sides of the reagent mounting groove 4-1 are provided with limiting ridges 4-1-1; the limiting ridges 4-1-1 are used to constrain the reagent strip 9 in the reagent mounting groove 4-1 to prevent the reagent strip 9 from jumping up and down.

[0029] In this embodiment, the reagent strip 9 is installed in the reagent installation slot 4 - 1 by inserting the reagent strip 9 from the end of the reagent installation slot 4 - 1 close to the positioning groove of the tip box to the limit position.

[0030] The tip box 5 is provided with one or more rows of tip storage holes 5-1. Each row of tip storage holes 5-1 includes a plurality of tip storage holes 5-1 corresponding to each reagent installation slot 4-1. The corresponding tip storage holes 5-1 are aligned with the reagent installation slot 4-1 along the axis of the guide rod 2.

[0031] During its movement, the slide 3 can be stopped at any position along the straight line, facilitating the completion of reactions and detection tasks with the pipette and luminescence detection sensor in the chemiluminescence instrument. Furthermore, the parallel multi-channel design of the reagent mounting rack 4 allows for simultaneous testing of multiple reagent strips 9, improving testing efficiency and reducing the overall size of the instrument.

[0032] like Figure 3 and Figure 4 As shown, each reagent installation slot 4-1 is equipped with a reagent strip retaining structure for accurately positioning the reagent strip 9. The reagent strip retaining structure includes a locking structure 4-2 and an end retaining step 4-3. The end retaining step 4-3 is located at the end of the bottom surface of the reagent installation slot 4-1 facing away from the tip box 5. It is used to cooperate with the bottom of the end surface of the reagent strip 9 to determine the position of the reagent strip 9 along the length of the reagent installation slot 4-1.

[0033] The bottom surface of the reagent installation slot 4-1 defines a limit mounting hole. A locking structure 4-2 is mounted within the limit mounting hole and comprises a locking plunger and an elastic member. The elastic member is positioned between the bottom surface of the limit mounting hole and the locking plunger, providing an upward spring force to the locking plunger. The top of the locking plunger (specifically, the portion protruding from the limit mounting hole) is spherical.

[0034] The reagent strip 9, which is compatible with the chemiluminescent sample incubation and detection platform provided in this embodiment, has a snap-in hole at its bottom. The position of the snap-in hole at the bottom of the reagent strip 9 matches the position of the locking structure 4-2. When the reagent strip 9 is inserted into the reagent installation slot 4-1, the top of the locking plunger engages the snap-in hole of the reagent strip 9, constraining the position of the reagent strip 9 in the reagent installation slot 4-1 during the incubation, reaction, and detection processes.

[0035] The heating component is installed inside the reagent mounting rack 4 or on the top of the slide 3, and is used to heat the reagent strip 9. In this embodiment, the heating component adopts a heating plate.

[0036] In this embodiment, the test strip 9 and the test tube 10, which ultimately performs sample testing, are separate components. A mounting hole for the test tube 10 is provided at the end of the test strip 9. The test tube 10 is supported at the top of the mounting hole in the test strip 9 by a circular ridge on the top of its outer side. The test tube 10 is inserted into the mounting hole after the test strip 9 is fully inserted. At this point, the end stop step on the reagent mounting slot 4-1 is located between the bottom of the test strip 9 and the bottom of the test tube 10.

[0037] The working principle of this embodiment is as follows:

[0038] First, the traverse drive assembly drives the slide 3 to move to the reagent strip installation position; the user takes out the tip box 5 and inserts the TIP tips 8 into each hole of the tip box 5.

[0039] Next, the reagent strip 9, containing the sample liquid to be tested, is pushed into the reagent mounting slot 4-1 in the reagent mounting rack 4. When fully inserted, the top of the locking plunger in the reagent mounting slot 4-1 engages the retaining hole of the reagent strip 9 with a click, confirming that the reagent strip 9 is fully inserted and mitigating the risk of the reagent strip 9 not being fully inserted. The tip box 5 containing the TIP tips 8 is then placed onto the slide 3.

[0040] Finally, the heating component heats and incubates the reagent strip 9; the transverse drive component drives the slide 3 to move to the chemiluminescence detection position, and cooperates with the corresponding pipette gun and luminescence detection sensor to react and detect the sample.

Claims

1. A chemiluminescence detection sample incubation detection platform, comprising a base, a slide (3), a reagent mounting frame (4) and a transverse drive assembly; characterized in that: The slide (3) is slidably connected to the base and driven by a transverse drive assembly; a reagent mounting rack (4) is fixed on the top of the slide (3); the reagent mounting rack (4) is provided with one or more reagent mounting slots (4-1); A reagent strip limiting structure is provided in the reagent installation groove (4-1); the reagent strip limiting structure comprises a locking structure (4-2) and an end limiting step (4-3); the end limiting step (4-3) is arranged at the end of the bottom surface of the reagent installation groove (4-1); the locking structure (4-2) comprises a locking plunger and an elastic member; the elastic member is used to apply elastic force to the locking plunger.

2. The chemiluminescence detection sample incubation detection platform according to claim 1, characterized in that: The slide (3) further comprises a guide rail (1) and a guide rod (2); the guide rail (1) and the guide rod (2) being parallel to each other are fixed on the base; one side of the bottom of the slide (3) is slidably connected to the guide rail (1) via a slider; and the other side of the bottom of the slide (3) is slidably connected to the guide rod (2) via a linear bearing.

3. The chemiluminescence detection sample incubation detection platform according to claim 1, characterized in that: The transverse drive assembly comprises a rail plate (6), a motor (7) and a roller (8); the rail plate (6) is fixed on the base; the roller (8) is rotatably connected to the slide (3), and the outer circumference is rollingly connected to the rail plate (6); the motor (7) is fixed on the slide (3), and the output shaft is coaxially fixed with the roller (8).

4. The chemiluminescence detection sample incubation detection platform according to claim 1, characterized in that: It also includes a tip box (5); a tip box positioning groove is provided on the top surface of the slide (3); the tip box (5) is placed in the tip box positioning groove; and the end limiting step (4-3) in the reagent installation groove (4-1) is located at the end of the reagent installation groove (4-1) away from the tip box positioning groove.

5. The chemiluminescence detection sample incubation detection platform according to claim 4, characterized in that: The tip box (5) is provided with one or more rows of tip storage holes (5-1); each row of tip storage holes (5-1) includes tip storage holes (5-1) corresponding to each reagent installation groove (4-1); the corresponding tip storage holes (5-1) and the reagent installation groove (4-1) are aligned along the sliding direction of the slide (3).

6. The chemiluminescence detection sample incubation detection platform according to claim 1, characterized in that: The multiple reagent installation slots (4-1) on the reagent installation rack (4) are arranged in sequence, and the arrangement direction is perpendicular to the sliding direction of the slide (3).

7. The chemiluminescence detection sample incubation detection platform according to claim 1, characterized in that: The tops of both sides of the reagent installation groove (4-1) are provided with limiting protrusions (4-1-1).

8. The chemiluminescence detection sample incubation detection platform according to claim 1, characterized in that: A limited installation hole is provided on the bottom surface of the reagent installation slot (4-1); and the locking structure (4-2) is installed in the limited installation hole.

9. The chemiluminescence detection sample incubation detection platform according to claim 1, characterized in that: The top of the locking plunger is spherical.

10. The chemiluminescence detection sample incubation detection platform according to claim 1, characterized in that: It also includes a heating component; the heating component is installed inside the reagent mounting rack (4) or on the top of the slide (3) and is used to heat the reagent strip (9).

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