Colloidal gold immunochromatography analyzer

Abstract

The colloidal gold immunochromatography analyzer provided by the utility model is used for detecting a colloidal gold immune layer reagent strip and comprises an outer shell, a fixed clamping piece, a detection assembly and a movable piece, and a detection opening for inserting the colloidal gold immune layer reagent strip is formed in the end part of the outer shell; the fixed clamping piece is fixed in the outer shell and is provided with an elastic clamping strip which is clamped with the part, inserted into the detection opening, of the colloidal gold immune layer reagent strip; the detection assembly is fixed on the fixed clamping piece and corresponds to the part, inserted into the detection opening, of the colloidal gold immune layer reagent strip; the movable piece is embedded in the outer shell in a sliding manner; the first position is in contact with the detection assembly and triggers the detection assembly to work, and the second position abuts against the elastic clamping strip and enables the elastic clamping strip to be separated from the colloidal gold immune layer reagent strip in a clamping mode. According to the utility model, the detection process is convenient and fast, additional operation is not needed, the learning cost of users is reduced, and the detection success rate is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of colloidal gold immunochromatographic analysis, in particular to a colloidal gold immunochromatographic analyzer. Background Art

[0002] Colloidal gold immunochromatography technology is a rapid detection technology that has emerged in recent years. It is a detection technology that often uses colloidal gold, latex particles, magnetic beads, fluorescein, etc. as tracer markers for antigen-antibody heterologous immune reactions. The principle is to use the strip-shaped fiber chromatography material of the inherent detection line as the stationary phase and the sample to be detected as the mobile phase. When the sample to be detected is dropped onto the test strip, the sample to be detected undergoes chromatographic movement through capillary action. When it moves to the detection line, the antigen in the sample combines with the specific antibody and is retained. The concentration of the conjugate is proportional to the concentration of the antibody in the sample. The higher the concentration, the darker the color. Analyzing its color value can complete this specific detection process.

[0003] Colloidal gold immunochromatographic analyzer is a device for detecting based on colloidal gold immunochromatographic technology. The colloidal gold immunochromatographic analyzer in the prior art, such as the colloidal gold immunochromatographic analyzer disclosed in the authorization announcement number CN212111438U, comprises a base, an analysis chamber is fixedly provided at one end of the top of the base, a colloidal gold analyzer is installed at the top of the analysis chamber, a lighting lamp is installed on the top side wall of the analysis chamber on the outside of the colloidal gold analyzer through a fixing piece, a display screen is provided on the top of the analysis chamber, and the display screen is electrically connected to the colloidal gold analyzer, a disinfection chamber is provided on one side of the analysis chamber at the top of the base, and the top of the disinfection chamber is connected by a fixing piece. Several ultraviolet lamps are evenly installed on the fixing parts. A mounting plate is fixedly provided on the top end of the base away from the analysis chamber. A screw is movably provided between the bottom end of the interior of the analysis chamber and the mounting plate through a rotating shaft. A motor is installed on the bottom end of one side outside the analysis chamber through a mounting seat. The output shaft end of the motor is connected to the rotating shaft where the screw is located through a coupling. Slide rods are fixedly provided on both sides of the screw between the bottom end of the interior of the analysis chamber and the mounting plate. A bearing frame is movably provided on the outer side of one end of the screw and the slide rod through a threaded hole and a mounting hole below the colloidal gold analyzer.

[0004] However, there are the following problems: the colloidal gold immunochromatographic analyzer is large in size, complex in structure, requires a fixed place of use, and has poor portability. Utility Model Content

[0005] In view of this, it is necessary to provide a colloidal gold immunochromatographic analyzer to achieve portable detection.

[0006] A colloidal gold immunochromatographic analyzer for detecting a colloidal gold immunochromatographic layer reagent strip, comprising:

[0007] An outer housing with a detection port at one end for inserting a colloidal gold immunoassay strip;

[0008] A fixed clamping member fixed inside the outer housing, having an elastic clamping strip that forms a clamping connection with a part of the colloidal gold immunoassay strip inserted into the detection port;

[0009] A detection component fixed on the fixed clamping member and corresponding to a part of the colloidal gold immunoassay strip inserted into the detection port, and

[0010] A movable member slidably embedded on the outer housing, having a first position in contact with the detection component to trigger the detection component to work and a second position in contact with the elastic clamping strip to disengage the elastic clamping strip from the clamping connection with the colloidal gold immunoassay strip.

[0011] Optionally, the detection component includes a circuit board, a detection sensor, a color recognition sensor, a detection switch, an LED lamp, and a controller. The circuit board is fixed on the fixed clamping member, and the detection sensor, the color recognition sensor, the detection switch, the LED lamp, and the controller are fixed on the circuit board. The controller is electrically connected to the detection sensor, the color recognition sensor, the detection switch, and the LED lamp. The detection sensor, the color recognition sensor, and the LED lamp correspond to a part of the colloidal gold immunoassay strip inserted into the detection port; the detection switch corresponds to the first position.

[0012] Optionally, the detection component further includes a display screen fixed on the circuit board and electrically connected to the controller.

[0013] Optionally, a through hole is provided at a position of the outer housing corresponding to the display screen, and a transparent protective lens is covered on the through hole.

[0014] Optionally, the fixed clamping member includes a pair of elastic clamping strips and a fixing main body. A fixing groove is provided on one surface of the fixing main body. The pair of elastic clamping strips are fixed on the other surface of the fixing main body and enclose with the fixing main body to form a sliding groove corresponding to the detection port. The circuit board is fixed in the fixing groove, and a plurality of through holes corresponding to the detection sensor, the color recognition sensor, and the LED lamp and communicating with the sliding groove are provided on the bottom surface of the fixing groove.

[0015] Optionally, one end of the elastic clamping strip is fixed to the fixing main body, and the other end is a free end. A convex block is provided at the end of the elastic clamping strip away from the fixing main body, and the convex block corresponds to and matches a notch on the colloidal gold immunoassay strip.

[0016] Optionally, the movable member includes a sliding block and an abutting piece. The sliding block is slidably connected to the fixed main body. The abutting piece is disposed in the sliding groove and is movably connected to the sliding block. The abutting piece has an abutting surface that abuts against the colloidal gold immunochromatographic reagent strip.

[0017] Optionally, a wedge block is provided on the outer surface of the sliding block. The wedge block has an inclined surface that abuts against the free end of the elastic clamping strip.

[0018] Optionally, an operation hole is formed in the outer housing corresponding to the position of the sliding block. A push button is provided on the sliding block and extends to the outside of the outer housing through the operation hole.

[0019] Optionally, the movable member further includes a spring. One end of the spring is fixed to the sliding block, and the other end is fixed to the abutting piece. When the colloidal gold immunochromatographic reagent strip pushes the abutting piece to move to the first position, the spring is in a compressed state.

[0020] The beneficial effects of the present invention are as follows:

[0021] The present invention provides a colloidal gold immunochromatographic analyzer, which has a relatively simple structure. By using the method of inserting and clamping and releasing the clamping during the pushing-out process, while ensuring the stable fixation of the reagent strip during the detection process, the detection process can be made convenient and fast, without additional operations, reducing the learning cost of the users and improving the detection success rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0023] Figure 1 It is a schematic structural diagram of the colloidal gold immunochromatographic analyzer of the present invention;

[0024] Figure 2 It is a schematic structural diagram of the colloidal gold immunochromatographic analyzer of the present invention from another angle;

[0025] Figure 3 It is a schematic internal structural diagram of the colloidal gold immunochromatographic analyzer of the present invention;

[0026] Figure 4 It is a schematic internal structural diagram of the colloidal gold immunochromatographic analyzer of the present invention from another angle;

[0027] Figure 5This is a schematic cross-sectional structure diagram of the colloidal gold immunochromatographic analyzer of the present utility model;

[0028] Figure 6 is Figure 5 a schematic structural diagram of the fixed clamping member in;

[0029] Figure 7 is Figure 5 a schematic structural diagram of the detection component in;

[0030] Where: 1 - outer housing, 11 - detection port, 12 - through hole, 13 - transparent protective lens, 14 - operation hole, 2 - detection component, 21 - circuit board, 22 - detection sensor, 23 - color recognition sensor, 24 - detection switch, 25 - LED light, 26 - display screen, 3 - fixed clamping member, 31 - elastic clamping strip, 32 - fixed main body, 321 - fixed groove, 322 - sliding groove, 323 - through hole, 4 - movable part, 41 - sliding block, 411 - wedge block, 412 - push button, 42 - abutting piece, 43 - spring. Specific embodiments

[0031] The following will specifically describe the preferred embodiments of the present utility model in conjunction with the accompanying drawings. The accompanying drawings form a part of this application and are used together with the embodiments of the present utility model to explain the principle of the present utility model, and are not used to limit the scope of the present utility model.

[0032] As Figures 1-7 shown, an embodiment of the present utility model provides a colloidal gold immunochromatographic analyzer for detecting a colloidal gold immunochromatographic reagent strip, including: an outer housing 1, a detection component 2, a fixed clamping member 3, and a movable part 4. The end of the outer housing 1 is provided with a detection port 11 for inserting the colloidal gold immunochromatographic reagent strip. The fixed clamping member 3 is fixed inside the outer housing 1 and has an elastic clamping strip 31 that forms a clamping connection with a part of the colloidal gold immunochromatographic reagent strip inserted into the detection port. The detection component 2 is fixed on the fixed clamping member 3 and corresponds to a part of the colloidal gold immunochromatographic reagent strip inserted into the detection port 11. The movable part 4 is slidably embedded on the outer housing 1 and has a first position where it contacts the detection component 2 and triggers the detection component 2 to work, and a second position where it abuts against the elastic clamping strip 31 to disengage the elastic clamping strip 31 from the colloidal gold immunochromatographic reagent strip. The movable part 4 is pushed by the colloidal gold immunochromatographic reagent strip to move to the first position or is pushed by an external force to the second position.

[0033] The present utility model provides a colloidal gold immunochromatographic analyzer with a relatively simple structure. By using the method of inserting and clamping and releasing the clamping during the pushing-out process, while ensuring the stable fixation of the reagent strip during the detection process, it can make the detection process convenient and fast, without additional operations, reduce the learning cost of the user, and improve the detection success rate.

[0034] Further, the outer surface of the outer housing 1 is transitioned by an arc surface, which is convenient for the operator to hold.

[0035] Further, the detection component 2 includes a circuit board 21, a detection sensor 22, a color recognition sensor 23, a detection switch 24, an LED lamp 25 and a controller. The circuit board 21 is fixed on the fixed clamping member 3. The detection sensor 22, the color recognition sensor 23, the detection switch 24, the LED lamp 25 and the controller are fixed on the circuit board 21. The controller is electrically connected to the detection sensor 22, the color recognition sensor 23, the detection switch 24 and the LED lamp 25. The detection sensor 22, the color recognition sensor 23 and the LED lamp 25 correspond to the part of the colloidal gold immunoassay strip inserted into the detection port 11; the detection switch 24 corresponds to the first position. When the moving member 4 is pushed by the colloidal gold immunoassay strip and moves to the first position, the moving member 4 contacts the detection switch 24, triggering the detection switch 24 to make the detection sensor 22, the color recognition sensor 23, the LED lamp 25 and the controller work; the LED lamp 25 irradiates the colloidal gold immunoassay strip. When the light source irradiates the detection line and the quality control line that have reacted with the sample, part of the light is absorbed, and the remaining unabsorbed light source is reflected onto the detection sensor 22 and the color recognition sensor 23. The detection sensor 22 detects the light source intensity, and the color recognition sensor 23 detects the color of the reflected light, converts the optical signal into an electrical signal, and transmits it to the controller. The absorbance of the detection line and the quality control line changes with the concentration of the gold-labeled conjugate. Therefore, the strength of the electrical signal converted by the detection sensor 22 also changes with the concentration of the gold-labeled conjugate. The controller stores and converts the collected signals into corresponding results; the color recognition sensor 23 judges the type of test strip by color (there are two colors covered on the test strip, corresponding to two detection items). The controller receives the signal recognized by the color recognition sensor 23, retrieves the calculation method corresponding to the item, and then calculates the corresponding result according to the strength of the electrical signal converted by the detection sensor 22 and the retrieved calculation method.

[0036] Further, the detection component 2 further includes a display screen 26. The display screen 26 is fixed on the circuit board 21 and is electrically connected to the controller for displaying the result calculated by the controller.

[0037] Further, a through hole 12 is formed at the position of the outer housing 1 corresponding to the display screen 26, and the through hole 12 is covered with a transparent protective lens 13.

[0038] Furthermore, the fixed clamping member 3 includes a pair of elastic clips 31 and a fixed body 32, a fixed groove 321 is provided on one side of the fixed body 32, a pair of the elastic clips 31 are fixed on the other side of the fixed body 32 and are combined with the fixed body 32 to form a sliding groove 322 corresponding to the detection port, the circuit board 21 is fixed in the fixed groove 321, and a plurality of through holes 323 corresponding to the detection sensor 22, the color recognition sensor 23, and the LED light 25 and connected to the sliding groove 322 are provided on the bottom surface of the fixed groove 321.

[0039] Furthermore, one end of the elastic clip 31 is fixed to the fixed body 32 and the other end is a free end. A bump 311 is provided on the end of the elastic clip 31 away from the fixed body 32, and the bump 311 corresponds to the notch on the colloidal gold immune layer reagent strip.

[0040] Furthermore, the movable part 4 includes a sliding block 41 and an abutment piece 42. The sliding block 41 is slidably connected to the fixed body 32. The abutment piece 42 is arranged in the sliding groove 322 and is movably connected to the sliding block 41. The abutment piece 42 has an abutment surface that abuts against the colloidal gold immune layer reagent strip. When the sliding block 41 and the abutment piece 42 are pushed to the first position by the colloidal gold immune layer reagent strip, the abutment piece 42 contacts the detection switch 24 and triggers the detection switch 24; when an external force pushes the sliding block 41 and the abutment piece 42 to slide to the second position, the sliding block 41 contacts the elastic clip 31 and pushes the elastic clip 31 to disengage from the colloidal gold immune layer reagent strip.

[0041] Furthermore, a wedge-shaped block 411 is provided on the outer surface of the sliding block 41, and the wedge-shaped block 411 has an inclined surface that abuts the free end of the elastic clip 31. When the sliding block 41 slides to the second position, the wedge-shaped block 411 contacts the free end of the elastic clip 31 and gradually expands the elastic clip 31, disengaging the elastic clip 31 from the colloidal gold immunoassay strip.

[0042] Furthermore, an operating hole 14 is formed in the outer shell 1 at a position corresponding to the sliding block 41 , and a push button 412 is provided on the sliding block 41 and extends to the outside of the outer shell 1 through the operating hole 14 .

[0043] Furthermore, the movable member 4 further includes a spring 43, one end of which is fixed to the sliding block 41, and the other end is fixed to the abutment piece 42. When the colloidal gold immune layer reagent strip pushes the abutment piece 42 to move toward the first position, the spring 43 is in a compressed state. When the sliding block 41 pushes the elastic clamping strip 31 to disengage the colloidal gold immune layer reagent strip, the abutment piece 42, under the action of the spring 43, pushes the colloidal gold immune layer reagent strip out of the detection port 11, thereby facilitating the removal of the colloidal gold immune layer reagent strip.

[0044] When in use, first insert the colloidal gold immune layer reagent strip to be tested from the detection port 11, the colloidal gold immune layer reagent strip contacts the abutment sheet 42, push the sliding block 41 and the abutment sheet 42 to slide to the first position, the abutment sheet 42 contacts the detection switch 24, triggering the detection switch 24; making the detection sensor 22, the color recognition sensor 23, the LED light 25 and the controller work; the LED light 25 illuminates the colloidal gold immune layer reagent strip, and when the light source is irradiated onto the detection line and the quality control line that have reacted with the sample, part of the light is absorbed, and the remaining unabsorbed light source is reflected to the On the detection sensor 22 and the color recognition sensor 23, the detection sensor 22 detects the intensity of the light source, and the color recognition sensor 23 detects the color of the reflected light, converts the light signal into an electrical signal, and transmits it to the controller. The absorbance of the detection line and the quality control line changes with the concentration of the gold label conjugate. Therefore, the strength of the electrical signal converted by the detection sensor 22 will also change with the concentration of the gold label conjugate. The controller stores the collected signal and converts it into a corresponding result; the color recognition sensor 23 determines the type of test strip by color (the test strip cover has two colors, corresponding to two detection items). The controller receives the signal recognized by the color recognition sensor 23, calls the calculation method of the corresponding item, and then calculates the corresponding result according to the strength of the electrical signal converted by the detection sensor 22 and the called calculation method; the display screen 26 displays the detection result; after the detection is completed, a thrust is applied to the push button 412 to push the sliding block 41 to slide to the second position, and the wedge block 411 contacts the free end of the elastic clip 31 and gradually stretches the elastic clip 31 to disengage the elastic clip 31 from the colloidal gold immune layer reagent strip. Under the action of the spring 43, the contact piece 42 pushes the colloidal gold immune layer reagent strip to pop out of the detection port 11, making it easy to remove the colloidal gold immune layer reagent strip.

[0045] The beneficial effects of the utility model are:

[0046] The utility model provides a colloidal gold immunochromatographic analyzer, which has a relatively simple structure. By adopting the methods of inserting and clamping and releasing the clamping during the pushing-out process, while ensuring the stable fixation of the reagent strip during the detection process, it can make the detection process convenient and fast, without additional operations, reduce the learning cost of the users, and improve the detection success rate.

[0047] The above are only the preferred specific embodiments of the present utility model, but the protection scope of the present utility model is not limited thereto. Any changes or substitutions that can be easily thought of by those skilled in the art within the technical scope disclosed by the present utility model should be covered within the protection scope of the present utility model.

Claims

1. A colloidal gold immunochromatographic analyzer for detecting colloidal gold immunochromatographic layer reagent strips, characterized in that: It includes: The outer shell has a detection port at the end for inserting the colloidal gold immune layer reagent strip; A fixed clamping member is fixed in the outer shell and has an elastic clamping strip that forms a clamping connection with the portion of the colloidal gold immune layer reagent strip inserted into the detection port; A detection component is fixed on the fixed clamp and corresponds to the portion of the colloidal gold immune layer reagent strip inserted into the detection port, and The movable part is slidably embedded in the outer shell and has a first position for contacting the detection component to trigger the detection component to work and a second position for abutting the elastic clip to disengage the elastic clip from the colloidal gold immune layer reagent strip.

2. The colloidal gold immunochromatographic analyzer according to claim 1, wherein The detection component includes a circuit board, a detection sensor, a color recognition sensor, a detection switch, an LED light and a controller. The circuit board is fixed on the fixed clamping part. The detection sensor, the color recognition sensor, the detection switch, the LED light and the controller are fixed on the circuit board. The controller is electrically connected to the detection sensor, the color recognition sensor, the detection switch and the LED light. The detection sensor, the color recognition sensor and the LED light correspond to the part of the colloidal gold immune layer reagent strip inserted into the detection port; the detection switch corresponds to the first position.

3. The colloidal gold immunochromatographic analyzer according to claim 2, wherein The detection component further includes a display screen, which is fixed on the circuit board and electrically connected to the controller.

4. The colloidal gold immunochromatographic analyzer according to claim 3, wherein A through hole is formed in the outer shell at a position corresponding to the display screen, and the through hole is covered with a transparent protective lens.

5. The colloidal gold immunochromatographic analyzer according to claim 2, wherein The fixed clamping component includes a pair of elastic clips and a fixed body, a fixed groove is provided on one side of the fixed body, a pair of elastic clips are fixed on the other side of the fixed body and are combined with the fixed body to form a sliding groove corresponding to the detection port, the circuit board is fixed in the fixed groove, and a plurality of through holes corresponding to the detection sensor, the color recognition sensor, and the LED light and connected to the sliding groove are provided on the bottom surface of the fixed groove.

6. The colloidal gold immunochromatographic analyzer according to claim 5, wherein One end of the elastic clip is fixed to the fixed body, and the other end is a free end. A bump is provided on the end of the elastic clip away from the fixed body, and the bump matches the notch on the colloidal gold immune layer reagent strip.

7. The colloidal gold immunochromatographic analyzer according to claim 6, wherein The movable part includes a sliding block and an abutment piece. The sliding block is slidably connected to the fixed body. The abutment piece is arranged in the sliding groove and movably connected to the sliding block. The abutment piece has an abutment surface abutting against the colloidal gold immune layer reagent strip.

8. The colloidal gold immunochromatographic analyzer according to claim 7, wherein A wedge block is provided on the outer surface of the sliding block, and the wedge block has an inclined surface abutting against the free end of the elastic clip.

9. The colloidal gold immunochromatographic analyzer according to claim 7, wherein: An operating hole is provided on the outer shell at a position corresponding to the sliding block, and a push button is provided on the sliding block and extends to the outside of the outer shell through the operating hole.

10. The colloidal gold immunochromatographic analyzer according to claim 7, wherein: The movable part further comprises a spring, one end of the spring is fixed to the sliding block, and the other end is fixed to the abutment sheet. When the colloidal gold immune layer reagent strip pushes the abutment sheet to move toward the first position, the spring is in a compressed state.

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