Fibronectin purification device

Abstract

The utility model discloses a fibronectin purification device which comprises a sterile box, a filter box and a plurality of filter assemblies, and the filter box is arranged in the sterile box; the multiple filter assemblies are arranged in the filter box, each filter assembly comprises a supporting box, a filter membrane, a sliding control frame, a control rod and two membrane pressing mechanisms, and the supporting box is arranged in the filter box; the filtering membrane is arranged on the supporting box; the sliding control frame is slidably arranged in the supporting box. One end of the control rod is connected with the sliding control frame, and the other end of the control rod extends out of the filter box; the two film pressing mechanisms are arranged on the two sides of the supporting box correspondingly. One end of the membrane pressing mechanism penetrates through the supporting box and abuts against the sliding control frame, and the other end of the membrane pressing mechanism abuts against the filtering membrane in a pressing mode. Therefore, the filter membrane is simple in mounting mode and convenient to operate, so that the mounting efficiency of the filter membrane is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of fibronectin processing, in particular to a fibronectin purification device. Background Art

[0002] Fibronectin is an extracellular matrix protein that is primarily involved in cell attachment, migration, and tissue repair. The purpose of filtration purification is to remove impurities and other proteins from the sample to obtain high-purity fibronectin, ensuring accuracy and effectiveness in research or applications. Currently, the purification process of fibronectin solutions typically involves filtration through multiple membranes.

[0003] In the process of installing the filter membrane of the existing fibronectin purification device, it is necessary to manually lift the film pressing plate on one side, place one side of the filter membrane under the film pressing plate, loosen the film pressing plate to flatten and fix one side of the filter membrane, then lift the film pressing plate on the other side, place the other side of the filter membrane under the film pressing plate, and flatten and fix the filter membrane on the other side to complete the installation of the filter membrane. However, the setting of multiple filter membranes for fibronectin makes the installation method of the above-mentioned filter membranes more cumbersome, thereby affecting the installation efficiency of the filter membrane. Utility Model Content

[0004] The utility model aims to solve one of the technical problems in the related art at least to a certain extent.

[0005] Therefore, the purpose of the present invention is to provide a fibronectin purification device, which has a simple installation method for the filter membrane and is convenient to operate, thereby improving the installation efficiency of the filter membrane.

[0006] To achieve the above-mentioned purpose, the utility model proposes a fibronectin purification device, comprising a sterile box, a filter box and multiple filter components, wherein the filter box is arranged in the sterile box; multiple filter components are respectively arranged in the filter box, and the filter component includes a support box, a filter membrane, a sliding control frame, a control rod and two film pressing mechanisms, wherein the support box is arranged in the filter box; the filter membrane is arranged on the support box; the sliding control frame is slidably arranged in the support box; one end of the control rod is connected to the sliding control frame, and the other end of the control rod extends to the outside of the filter box; the two film pressing mechanisms are respectively arranged on both sides of the support box; one end of the film pressing mechanism passes through the support box and abuts against the sliding control frame, and the other end of the film pressing mechanism is pressed and abutted against the filter membrane.

[0007] The utility model provides a fibronectin purification device, and the installation method of the filter membrane is simple and the operation is convenient, thereby improving the installation efficiency of the filter membrane.

[0008] In addition, the fibronectin purification device proposed in the present application may also have the following additional technical features:

[0009] Specifically, the sliding control frame includes a push plate, two drive plates and a first spring, wherein the push plate is slidably arranged in the support box; the two drive plates are respectively arranged on both sides of the push plate and are respectively slidably connected to the support box; a height block is provided on the drive plate, and one end of the film pressing mechanism is in sliding contact with the height block; the first spring is provided in the support box, one end of the first spring is connected to the push plate, and the other end of the first spring is connected to the support box.

[0010] Specifically, the film pressing mechanism includes a limit box, an abutment block, a second spring, a connecting rod and a film pressing piece, wherein the bottom of the limit box is open and is covered on the support box; the abutment block is slidably arranged in the limit box, and one end of the abutment block passes through the support box and is slidably abutted against the height block; the second spring is arranged in the limit box, one end of the second spring is connected to the limit box, and the other end of the second spring is connected to the abutment block; one end of the connecting rod is connected to the abutment block through a sliding hole opened on the limit box, and the other end of the connecting rod is connected to the film pressing piece; the film pressing piece is pressed and abutted against the filter membrane.

[0011] Specifically, a roller is provided at the bottom of the abutment block, and the roller is in sliding abutment with the height block.

[0012] Specifically, the control rod includes a rotating rod and a connecting block, wherein one end of the connecting block is connected to the push plate, and the other end of the connecting block extends to the outside of the filter box; the rotating rod is rotatably set at the other end of the connecting block, and a clamping block is provided on the rotating rod, and the clamping block is rotatably clamped with the support box.

[0013] Additional aspects and advantages of the present invention will be given in part in the following description and in part will become apparent from the following description or learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which:

[0015] Figure 1 This is a schematic structural diagram of a fibronectin purification device according to one embodiment of the present invention;

[0016] Figure 2 This is a schematic structural diagram of a filter assembly according to an embodiment of the present invention;

[0017] Figure 3 This is a structural diagram of a support box without a filter membrane installed in one embodiment of the present invention;

[0018] Figure 4 A cross-sectional view of a support box according to an embodiment of the present invention;

[0019] Figure 5This is a structural diagram of a sliding control frame and a control rod according to an embodiment of the present invention;

[0020] Figure 6 This is a structural schematic diagram of a film pressing mechanism according to an embodiment of the present invention.

[0021] As shown in the figure: 1. Sterile box; 2. Filter box; 3. Filter assembly; 30. Support box; 31. Filter membrane; 32. Slide control frame; 320. Push plate; 321. Drive plate; 3210. Height block; 322. First spring; 33. Control rod; 330. Rotating rod; 3300. Clamping block; 331. Connecting block; 34. Film pressing mechanism; 340. Limit box; 3400. Slide hole; 341. Abutment block; 3410. Roller; 342. Second spring; 343. Connecting rod; 344. Film pressing sheet. DETAILED DESCRIPTION

[0022] The following describes in detail embodiments of the present invention, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention. On the contrary, the embodiments of the present invention include all variations, modifications, and equivalents that fall within the spirit and scope of the appended claims.

[0023] The fibronectin purification device according to an embodiment of the present invention will be described below with reference to the accompanying drawings.

[0024] like Figures 1-6 As shown, the fibronectin purification device according to the embodiment of the present invention may include a sterile box 1 , a filter box 2 and a plurality of filter components 3 .

[0025] The filter box 2 is arranged in the sterile box 1 .

[0026] It should be noted that the sterile box 1 described in this embodiment is provided with a box door, so as to facilitate the installation of the filter box 2.

[0027] A plurality of filter assemblies 3 are respectively arranged in the filter box 2 . The filter assemblies 3 may include a support box 30 , a filter membrane 31 , a slide control frame 32 , a control rod 33 and two film pressing mechanisms 34 .

[0028] It should be noted that the multiple filter assemblies 3 described in this embodiment are detachably arranged on the filter box 2, so as to facilitate the replacement of the filter membrane 31.

[0029] The support box 30 is arranged in the filter box 2 .

[0030] It should be noted that the support box 30 described in this embodiment is in the shape of a "mouth", that is, the middle part of the support box 30 is a through hole, so that after the filter membrane 31 is installed in the support box 30, the fibronectin solution can be filtered through the through hole for purification operation.

[0031] The filter membrane 31 is arranged on the support box 30 .

[0032] It should be noted that the filter membranes 31 on the multiple filter components 3 described in this embodiment are of the same size, but the pore sizes of the filter holes on the filter membranes 31 are different. The multiple filter components 3 are arranged in sequence from top to bottom according to the size of the filter pores, thereby ensuring the filtering and purification effect of fibronectin.

[0033] The sliding control frame 32 is slidably disposed in the support box 30 .

[0034] It is understandable that by sliding the slide control frame 32 in the support box 30 , the film pressing assembly can be lifted up, so that a gap is generated between one end of the film pressing assembly and the support box 30 , thereby facilitating the installation of the filter membrane 31 .

[0035] One end of the control rod 33 is connected to the sliding control frame 32, and the other end of the control rod 33 extends to the outside of the filter box 2. The two film pressing mechanisms 34 are respectively arranged on both sides of the support box 30. One end of the film pressing mechanism 34 passes through the support box 30 and abuts against the sliding control frame 32, and the other end of the film pressing mechanism 34 presses and abuts against the filter membrane 31.

[0036] It can be understood that, through the setting of the control rod 33, the relevant staff only needs to press the control rod 33 to lift the two film pressing mechanisms 34 in the film pressing assembly, and install the two sides of the filter membrane 31 under the two film pressing mechanisms 34 respectively. By loosening the control rod 33, the filter membrane 31 can be limited and clamped. The operation is simple, which improves the installation efficiency of the filter membrane 31.

[0037] When the filter membrane 31 is installed, the staff can press the control rod 33 to push the sliding frame 32 to slide in the support box 30. When the sliding frame 32 slides in the support box 30, the staff can drive the two film pressing mechanisms 34 abutting against the sliding frame 32 to move upward, so that a gap is generated between one end of the film pressing mechanism 34 and the support box 30. The staff can place the two sides of the filter membrane 31 under the two film pressing mechanisms 34 respectively. After the placement is completed, the control rod 33 returns to its initial position, driving the sliding frame 32 to return to its initial position and making the two film pressing mechanisms 34 return to their initial position (the initial position of the film pressing mechanism 34 is that one end of the film pressing mechanism 34 abuts against the support box 30), thereby limiting and tightening the two sides of the filter membrane 31.

[0038] After the multiple filter components 3 are installed, the fibronectin solution enters the filter box 2 from the feed pipe (not shown in the figure) provided on the filter box 2 and is filtered by the multiple filter components 3 to achieve filtration and purification of the fibronectin.

[0039] In one embodiment of the present invention, Figure 2-Figure 5 As shown, the slide control frame 32 may include a push plate 320 , two drive plates 321 and a first spring 322 .

[0040] Among them, the push plate 320 is slidably set in the support box 30, and the two driving plates 321 are respectively set on both sides of the push plate 320 and are respectively slidably connected to the support box 30. A height block 3210 is set on the driving plate 321, and one end of the film pressing mechanism 34 slides and abuts against the height block 3210. The first spring 322 is set in the support box 30, one end of the first spring 322 is connected to the push plate 320, and the other end of the first spring 322 is connected to the support box 30.

[0041] It can be understood that, through the provision of the first spring 322, the relevant personnel can release the control rod 33 after pressing the control rod 33 and completing the relevant operation. The first spring 322 will push the push plate 320 by pressing the control rod 33, and after squeezing the elastic deformation generated by the first spring 322, it will restore the elastic deformation and push the push plate 320 to return to its initial position, and push the control rod 33 to its initial position, thereby eliminating the need for relevant personnel to manually pull back the control rod 33, thereby improving the installation efficiency of the filter membrane 31.

[0042] It can be understood that by setting the height block 3210 on the driving plate 321, one end of the film pressing mechanism 34 can slide from the sliding control frame 32 to the height block 3210, so that the movement of the driving plate 321 can control the rise and fall of the film pressing mechanism 34.

[0043] In one embodiment of the present invention, Figure 2-Figure 6 As shown, the film pressing mechanism 34 may include a limit box 340 , an abutment block 341 , a second spring 342 , a connecting rod 343 and a film pressing sheet 344 .

[0044] Among them, the bottom of the limit box 340 is open and is covered on the support box 30, the abutment block 341 is slidably set in the limit box 340, and one end of the abutment block 341 passes through the support box 30 and slides and abuts against the height block 3210, the second spring 342 is set in the limit box 340, one end of the second spring 342 is connected to the limit box 340, and the other end of the second spring 342 is connected to the abutment block 341, one end of the connecting rod 343 is connected to the abutment block 341 through the sliding hole 3400 opened on the limit box 340, and the other end of the connecting rod 343 is connected to the pressing film 344, and the pressing film 344 is pressed and abutted against the filter membrane 31.

[0045] It can be understood that, by providing the second spring 342 , it is possible to ensure that the membrane pressing piece 344 is continuously pressed against the filter membrane 31 .

[0046] In one embodiment of the present invention, Figure 2-Figure 6 As shown, a roller shaft 3410 is provided at the bottom of the abutment block 341 , and the roller shaft 3410 is in sliding abutment with the height block 3210 .

[0047] It can be understood that, by disposing the roller shaft 3410 , the sliding friction between the abutment block 341 and the height block 3210 and the driving plate 321 can be reduced.

[0048] In one embodiment of the present invention, Figure 2-Figure 5 As shown, the control lever 33 may include a rotating lever 330 and a connecting block 331 .

[0049] One end of the connecting block 331 is connected to the push plate 320, and the other end of the connecting block 331 extends to the outside of the filter box 2;

[0050] The rotating rod 330 is rotatably disposed at the other end of the connecting block 331 . A clamping block 3300 is disposed on the rotating rod 330 . The clamping block 3300 is rotatably clamped with the supporting box 30 .

[0051] It should be noted that the filter box 2 and the support box 30 described in this embodiment are respectively provided with through holes through which the clamping block 3300 can pass, and after the clamping block 3300 is pressed into the support box 30, when the first spring 322 pushes the push plate 320, the clamping block 3300 can be clamped on the support box 30 by rotating the rotating rod 330, so that the operator does not need to continuously press the control lever 33, thereby improving the use effect of the device.

[0052] Specifically, during the actual operation, the relevant staff opens the sterile box 1, installs the filter box 2 in the sterile box 1, and installs multiple filter components 3 in the filter box 2 in turn. When the filter membrane 31 is installed, the relevant staff presses the control rod 33, and the control rod 33 pushes the sliding control frame 32 to slide in the support box 30, and pushes multiple height blocks 3210 to abut against the corresponding abutment blocks 341, so that the abutment blocks 341 move upward. When the abutment blocks 341 move upward, they drive the connecting rod 343 and the film pressing plate to move upward, thereby creating a gap between the film pressing plate and the support box 30. The relevant staff places the two sides of the filter membrane 31 respectively under the film pressing plate. After the placement is completed, the control rod 33 returns to its initial position, drives the sliding control frame 32 to return to its initial position, and makes the two film pressing mechanisms 34 return to their initial positions, thereby limiting and tightening the two sides of the filter membrane 31.

[0053] After the multiple filter components 3 are installed, the fibronectin solution enters the filter box 2 from the feed pipe provided on the filter box 2 and is filtered by the multiple filter components 3 to achieve filtration and purification of the fibronectin.

[0054] In summary, in the fibronectin purification device of the embodiment of the present invention, the installation method of the filter membrane is simple and the operation is convenient, thereby improving the installation efficiency of the filter membrane.

[0055] In this specification, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of technical features indicated. Therefore, a feature specified as "first" or "second" may explicitly or implicitly include at least one of such features. In the description of this utility model, "plurality" means at least two, for example, two, three, etc., unless otherwise specifically defined.

[0056] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and features of different embodiments or examples without contradiction.

[0057] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are illustrative and cannot be understood as limitations on the present invention. Ordinary technicians in this field can change, modify, replace and deform the above embodiments within the scope of the present invention.

Claims

1. A fibronectin purification device, characterized in that: It includes a sterile box, a filter box and multiple filter components, among which, The filter box is arranged in the sterile box; The plurality of filter assemblies are respectively arranged in the filter box, and the filter assembly includes a support box, a filter membrane, a slide control frame, a control rod and two film pressing mechanisms, wherein: The support box is arranged in the filter box; The filter membrane is arranged on the support box; The sliding control frame is slidably arranged in the supporting box; One end of the control rod is connected to the sliding control frame, and the other end of the control rod extends to the outside of the filter box; The two film pressing mechanisms are respectively arranged on both sides of the support box; One end of the film pressing mechanism passes through the support box and abuts against the slide control frame, and the other end of the film pressing mechanism presses and abuts against the filter membrane.

2. The fibronectin purification device according to claim 1, characterized in that: The slide control frame includes a push plate, two drive plates and a first spring, wherein: The push plate is slidably arranged in the support box; The two driving plates are respectively arranged on both sides of the push plate and are respectively slidably connected to the support box; The driving plate is provided with a height block, and one end of the film pressing mechanism is in sliding contact with the height block; The first spring is arranged in the support box, one end of the first spring is connected to the push plate, and the other end of the first spring is connected to the support box.

3. The fibronectin purification device according to claim 2, characterized in that: The film pressing mechanism includes a limit box, an abutment block, a second spring, a connecting rod and a film pressing sheet, wherein: The bottom of the limit box is open and is covered on the support box; The abutment block is slidably arranged in the limit box, and one end of the abutment block passes through the support box and slidably abuts against the height block; The second spring is arranged in the limit box, one end of the second spring is connected to the limit box, and the other end of the second spring is connected to the abutment block; One end of the connecting rod is connected to the abutment block through a sliding hole provided on the limit box, and the other end of the connecting rod is connected to the film pressing sheet; The membrane pressing sheet is pressed and abutted against the filter membrane.

4. The fibronectin purification device according to claim 3, characterized in that: A roller is provided at the bottom of the abutment block, and the roller is in sliding abutment with the height block.

5. The fibronectin purification device according to claim 4, characterized in that: The control rod includes a rotating rod and a connecting block, wherein, One end of the connecting block is connected to the push plate, and the other end of the connecting block extends to the outside of the filter box; The rotating rod is rotatably arranged at the other end of the connecting block. A clamping block is arranged on the rotating rod, and the clamping block is rotatably clamped with the supporting box.

Images