Microscopic detection instrument for cell factory

Abstract

The utility model relates to a microscopic detection instrument for a cell factory. The microscopic detection instrument comprises a rack, a cell factory clamp, an imaging component and a moving assembly, the rack is provided with a containing cavity and two penetrating openings. The cell factory clamp is arranged on the rack; the imaging assembly comprises a light source and a microscopic camera, and the light source and the microscopic camera have original positions and working positions; the moving assembly is arranged in the containing cavity and comprises a first moving device and two second moving devices, the two second moving devices are both arranged on the first moving device, and the light sources and the microscopic cameras are arranged on the second moving devices in a one-to-one correspondence mode. Through driving of the first moving device, the light source and the microscopic camera can cover the cell factory units one by one, the cell culture amount can be increased, and the detection efficiency can be improved. Through driving of the second moving device, the light source and the microscopic camera can be retracted into the accommodating cavity when detection is not needed, so that a dustproof effect can be achieved, and the light source and the microscopic camera can be prevented from being damaged due to unintentional collision.

Description

Technical Field

[0001] The utility model relates to the technical field of bioengineering, in particular to a cell factory microscopic detection instrument. Background Art

[0002] With the continuous development and advancement of biotechnology, cell factories have gradually become a hot topic in the fields of cell therapy, biomedicine, and biopharmaceuticals. In order to be able to detect parameters such as cell viability, proliferation, and morphological changes in real time, cell factory microscopic detection instruments have emerged.

[0003] Related existing technologies, the cell factory microscopic detection instrument includes a carrier, a cell factory unit, a light source and a microscopic camera, the cell factory unit is arranged on the carrier, the light source and the microscopic camera are fixed on the carrier, and the light source and the microscopic camera are facing the cell factory unit.

[0004] However, the fixed connection between the light source and the microscope camera makes them immobile, which limits the number of layers and total number of cell factory units in the cell factory. This makes it difficult to culture and test cells in large quantities, and only allows for small amounts of cells to be cultured and tested. Utility Model Content

[0005] Based on the above description, the utility model provides a cell factory microscopic detection instrument, which aims to solve the problem that the existing light source and microscopic camera cannot be moved, making it difficult to achieve large-scale cell culture and detection.

[0006] The technical solution of the utility model to solve the above technical problems is as follows:

[0007] A cell factory microscopic detection instrument, comprising:

[0008] A frame having an accommodating cavity and two through-holes, both of which are connected to the accommodating cavity, and the two through-holes are spaced apart along a first direction;

[0009] A cell factory clamp is provided on the frame and is used to clamp the cell factory;

[0010] An imaging assembly, comprising a light source and a microscopic camera, wherein the light source and the microscopic camera are spaced apart along a first direction, and the light source and the microscopic camera have an original position and a working position;

[0011] A moving assembly is provided in the accommodating cavity, and the moving assembly includes a first moving device and two second moving devices. The two second moving devices are arranged at intervals along the first direction, and the two second moving devices are both provided on the first moving device. The light source and the microscope camera are provided on the second moving device in a one-to-one correspondence. The first moving device is used to drive the light source and the microscope camera to move along the second direction, and the second moving device is used to drive the light source and the microscope camera to switch between the original position and the working position.

[0012] On the basis of the above technical solution, the present invention can also be improved as follows.

[0013] Furthermore, the rack is provided with a flip door corresponding to each of the openings.

[0014] Furthermore, the frame is provided with at least two pairs of support members.

[0015] Furthermore, the frame is provided with shutters.

[0016] Furthermore, the first moving device includes a first driving mechanism, a supporting assembly and a third connecting plate, the first driving mechanism includes a second connecting plate and a first linear motion assembly, the first linear motion assembly is arranged on the second connecting plate, the supporting assembly includes a third connecting plate and at least one second sliding member, at least one second sliding member is arranged on the third connecting plate, and the third connecting plate is connected to the first linear motion assembly and the second sliding member.

[0017] Furthermore, the second moving device includes a moving plate, a mounting frame, a second driving member and a third sliding member, the mounting frame is arranged at one end of the moving plate close to the through-hole, and the second driving member and the third sliding member are both connected to the third connecting plate and the moving plate.

[0018] Furthermore, the second moving device includes a shell, the shell is connected to the third connecting plate, the moving plate, the second driving member and the third sliding member are all located in the shell, and an opening for the moving plate to move is opened on the shell.

[0019] Furthermore, the moving assembly includes two third moving devices, both of which are arranged on the side of the third connecting plate away from the first driving mechanism, and the two third moving devices are arranged at intervals along the first direction. The third moving device includes a second linear motion component and a connecting frame, and the connecting frame is arranged on the second linear motion component. The second driving member and the third sliding member are both connected to the connecting frame and the moving plate, and the shell is connected to the connecting frame.

[0020] Furthermore, the first linear motion assembly and the second linear motion assembly include a first driving member and at least one pair of first sliding members, and each pair of first sliding members is axisymmetric about the central axis of the first driving member.

[0021] Compared with the prior art, the technical solution of this application has the following beneficial technical effects:

[0022] (1) This application uses a first moving device to drive the light source and the microscope camera to cover each cell factory unit one by one, which can not only increase the cell culture volume but also improve the detection efficiency. When driven by a second moving device, the light source and the microscope camera can be retracted into the accommodating chamber when no detection is required, which can not only play a dust-proof role but also prevent the light source and the microscope camera from being damaged by accidental collision.

[0023] (2) The present application is driven by a third moving device, so that the light source and the microscope camera move toward or away from each other along a third direction, thereby being able to adjust the distance between the light source and the microscope camera to adapt to the number of layers of the cell factory, thereby ensuring accurate detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a general assembly diagram of a cell factory microscopic detection instrument provided in an embodiment of the present utility model;

[0025] Figure 2 This is a schematic structural diagram of a frame in an embodiment of the present utility model;

[0026] Figure 3 This is a schematic structural diagram of the moving assembly in an embodiment of the present utility model;

[0027] Figure 4 This is a structural diagram of the first driving mechanism in an embodiment of the present utility model;

[0028] Figure 5 This is a schematic structural diagram of the support assembly in an embodiment of the present utility model;

[0029] Figure 6 This is a schematic structural diagram of a second mobile device from one perspective in an embodiment of the present utility model;

[0030] Figure 7 This is a structural diagram of the second mobile device in another perspective in an embodiment of the present utility model;

[0031] Figure 8 Schematic diagram of the structure of the third moving device in the embodiment of the present utility model.

[0032] In the accompanying drawings, the components represented by the reference numerals are as follows:

[0033] 10. Frame; 11. Through-hole; 12. Flip-up door; 13. Support; 14. Shutter;

[0034] 20. Cell factory fixture;

[0035] 30. Imaging component; 31. Light source; 32. Microscope camera;

[0036] 40. Moving assembly; 41. First moving device; 411. First driving mechanism; 4111. First connecting plate; 4112. First linear motion component; 41121. First driving member; 411211. First driving motor; 411212. Transmission part; 411213. Connecting part; 41122. First sliding member; 412. Supporting assembly; 4121. Second connecting plate; 4122. Second sliding member; 413. Third connecting plate; 42. Second moving device; 421. Moving plate; 422. Mounting frame; 423. Second driving member; 424. Third sliding member; 425. Housing; 43. Third moving device; 431. Second linear motion component; 4311. Second driving motor; 4312. Screw rod; 4313. Nut seat; 432. Connecting frame. DETAILED DESCRIPTION

[0037] To facilitate understanding of the present application, the present application will be described more fully below with reference to the accompanying drawings. The accompanying drawings provide embodiments of the present application. However, the present application may be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to make the disclosure of the present application more thorough and comprehensive.

[0038] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application pertains. The terms used herein in the specification of this application are for the purpose of describing specific embodiments only and are not intended to limit this application.

[0039] It will be understood that spatial relational terms such as "under," "beneath," "below," "under," "above," "above," etc., may be used herein to describe the relationship of an element or feature shown in the figures to other elements or features. It will be understood that in addition to the orientations shown in the figures, spatial relational terms also include different orientations of the device in use and operation. For example, if the device in the drawings is turned over, the element or feature described as "under" or "beneath" or "beneath" the other elements will be oriented as "above" the other elements or features. Thus, the exemplary terms "under" and "under" may include both upper and lower orientations. In addition, the device may also include alternative orientations (e.g., rotated 90 degrees or other orientations), and the spatial descriptors used herein are interpreted accordingly.

[0040] When used herein, the singular forms "a", "an", and "the" may also include the plural forms, unless the context clearly indicates otherwise. It should also be understood that the terms "include / comprise" or "have" and the like specify the presence of stated features, integers, steps, operations, components, parts, or combinations thereof, but do not preclude the possibility of the presence or addition of one or more other features, integers, steps, operations, components, parts, or combinations thereof.

[0041] Refer to the attached Figures 1 to 8 As shown, the utility model provides a technical solution: a cell factory microscopic detection instrument, including a frame 10, a cell factory fixture 20, an imaging component 30 and a moving assembly 40; the frame 10 has a receiving cavity and two through-holes 11, both of which are connected to the receiving cavity, and the two through-holes 11 are spaced apart along a first direction; the cell factory fixture 20 is provided on the frame 10, and the cell factory fixture 20 is used to clamp the cell factory; the imaging component 30 includes a light source 31 and a microscopic camera 32, and the light source 31 and the microscopic camera 32 are spaced apart along the first direction. It has an original position and a working position; the moving assembly 40 is arranged in the accommodating cavity, and the moving assembly 40 includes a first moving device 41 and two second moving devices 42, the two second moving devices 42 are arranged at intervals along the first direction, and the two second moving devices 42 are both arranged on the first moving device 41, the light source 31 and the microscope camera 32 are arranged on the second moving device 42 in a one-to-one correspondence, the first moving device 41 is used to drive the light source 31 and the microscope camera 32 to move along the second direction, and the second moving device 42 is used to drive the light source 31 and the microscope camera 32 to switch between the original position and the working position.

[0042] The specific structure of the cell factory fixture 20 is described in the utility model patent No. CN219430013U, and therefore will not be described in detail here.

[0043] It should be noted that the light source 31 and the microscope camera 32 are in their original positions when they are in the accommodating cavity; and they are in their working positions when they are opposite to the cell factory.

[0044] For example, the light source 31 can be an LED lamp, etc. The cell factory fixture 20 can hold M cell factory units; each cell factory unit can be an N-layer cell factory, for example, N∈[1,40]. The light source 31 and the microscope camera 32 can be positioned either above or below the microscope camera 32.

[0045] According to this embodiment, during detection, the second moving device 42 drives the light source 31 and the micro camera 32 to move along the third direction, moving the light source 31 and the micro camera 32 through the opening 11 to the working position. At the same time, the first moving device 41 drives the light source 31 and the micro camera 32 to move along the second direction, aligning the light source 31 and the micro camera 32 with each cell factory unit, and the light source 31 and the micro camera 32 cooperate to detect the cells in the cell factory. In this way, driven by the first moving device 41, the light source 31 and the micro camera 32 can cover each cell factory unit one by one, which can increase the cell culture volume and improve the detection efficiency. Driven by the second moving device 42, the light source 31 and the micro camera 32 can be recovered to the accommodating chamber when no detection is needed, which can not only play a dust-proof role, but also prevent the light source 31 and the micro camera 32 from being accidentally hit and damaged.

[0046] Refer to the attached Figures 1-2 As shown, in some embodiments, the rack 10 is provided with a flip door 12 corresponding to each through opening 11 .

[0047] According to this embodiment, when the light source 31 and the microscope camera 32 are not required for detection, after the cell factory fixture 20 is removed, the flip door 12 can be used to close the opening 11, thereby preventing dust from entering the accommodating cavity.

[0048] Refer to the attached Figures 1-2 As shown, in some embodiments, at least two pairs of support members 13 are provided on the frame 10 .

[0049] Exemplarily, at least two pairs of support members 13 may be located at the bottom of the frame 10, or the two pairs of support members 13 may be foot-brake type universal wheels or Forma wheels.

[0050] In the present invention, the support member 13 is a Forma wheel.

[0051] According to this embodiment, the support member 13 not only plays a supporting role, but also facilitates the movement of the frame 10 .

[0052] Refer to the attached Figures 1-2 As shown, in some embodiments, the frame 10 is provided with shutters 14 .

[0053] According to this embodiment, the shutters 14 can play a role in both heat dissipation and dust prevention.

[0054] Refer to the attached Figures 3-5As shown, in some embodiments, the first moving device 41 includes a first driving mechanism 411, a support assembly 412 and a third connecting plate 413, the first driving mechanism 411 includes a second connecting plate 4121 and a first linear motion assembly 4112, the first linear motion assembly 4112 is arranged on the second connecting plate 4121, the support assembly 412 includes a third connecting plate 413 and at least one second sliding member 4122, at least one second sliding member 4122 is arranged on the third connecting plate 413, and the third connecting plate 413 is connected to the first linear motion assembly 4112 and the second sliding member 4122.

[0055] For example, the first linear motion assembly 4112 can be a linear module, etc. Alternatively, the first linear motion assembly 4112 includes a first driving member 41121 and at least one pair of first sliding members 41122, each pair of first sliding members 41122 being axisymmetric about the central axis of the first driving member 41121. For example, the first driving member 41121 can be a pneumatic cylinder, a hydraulic cylinder, an electric push rod, or an electric cylinder, etc. Alternatively, the first drive member 41121 may include a first drive motor 411211, two transmission parts 411212, and a connecting part 411213, wherein one transmission part 411212 is provided at the output end of the first drive motor 411211, the two transmission parts 411212 are spaced apart along the second direction, and the connecting part 411213 is connected to the two transmission parts 411212; the transmission parts 411212 may be gears or synchronous wheels, and the connecting part 411213 may be a chain or a synchronous toothed belt; when the transmission parts 411212 are gears, the connecting part 411213 is a chain; when the transmission parts 411212 are synchronous wheels, the connecting part 411213 is a synchronous toothed belt. Alternatively, the first drive member 41121 may include a third drive motor, a screw rod 4312, or a nut seat 4313, one end of the screw rod 4312 is connected to the third drive motor, and the nut seat 4313 is threadedly engaged with the screw rod 4312. The first sliding member 41122 and the second sliding member 4122 may include a guide rail and a slider. Alternatively, the first sliding member 41122 and the second sliding member 4122 may include an optical axis and a linear bearing.

[0056] In the present invention, the first driving member 41121 of the first linear motion assembly 4112 includes a first driving motor 411211 , two transmission parts 411212 and a connecting part 411213 .

[0057] According to this embodiment, the first linear motion component 4112 drives the third connecting plate 413 to move along the second direction, which can drive the two second moving devices 42, the light source 31 and the microscope camera 32 to move along the second direction, so that the light source 31 and the microscope camera 32 correspond to each cell factory unit.

[0058] Refer to the attached Figure 3 and 6As shown in Figures 1-7, in some embodiments, the second moving device 42 includes a moving plate 421, a mounting bracket 422, a second driving member 423, and a third sliding member 424. The mounting bracket 422 is disposed at one end of the moving plate 421 near the through-opening 11. The second driving member 423 and the third sliding member 424 are both connected to the third connecting plate 413 and the moving plate 421.

[0059] Exemplarily, the second driving member 423 may be a pneumatic cylinder, a hydraulic cylinder, an electric push rod, or an electric cylinder. Alternatively, the second driving member 423 may include a second driving motor 4311, a gear, and a rack, wherein the gear is sleeved on the output end of the second driving motor 4311, and the rack is mounted on the movable plate 421, meshing with the gear. The third sliding member 424 may include a guide rail and a slider. Alternatively, the first sliding member 41122 and the second sliding member 4122 may include an optical axis and a linear bearing.

[0060] According to this embodiment, the second linear motion assembly 431 provides power to move the movable plate 421 along the third direction, thereby enabling the light source 31 and the microscope camera 32 to switch between the original position and the working position.

[0061] Refer to the attached Figure 3 As shown, in some embodiments, the second moving device 42 includes a shell 425, which is connected to the third connecting plate 413, and the moving plate 421, the second driving member 423 and the third sliding member 424 are all located in the shell 425, and an opening is provided on the shell 425 for moving the moving plate 421.

[0062] According to this embodiment, the housing 425 protects the movable plate 421 , the second driving member 423 and the third sliding member 424 to reduce dust accumulation.

[0063] Refer to the attached Figure 3 and 8 As shown, in some embodiments, the moving assembly 40 includes two third moving devices 43, and the two third moving devices 43 are both located on the side of the third connecting plate 413 away from the first driving mechanism 411. The two third moving devices 43 are spaced apart along the first direction, and the third moving device 43 includes a second linear motion component 431 and a connecting frame 432. The connecting frame 432 is located on the second linear motion component 431, and the second driving member 423 and the third sliding member 424 are both connected to the connecting frame 432 and the moving plate 421, and the shell 425 is connected to the connecting frame 432.

[0064] For example, the second linear motion assembly 431 may be a linear module, etc. Alternatively, the second linear motion assembly 431 includes a first driving member 41121 and at least one pair of first sliding members 41122, each pair of first sliding members 41122 being axisymmetric about the central axis of the first driving member 41121. For example, the first driving member 41121 may be a pneumatic cylinder, a hydraulic cylinder, an electric push rod, or an electric cylinder, etc. Alternatively, the first drive member 41121 may include a first drive motor 411211, two transmission parts 411212, and a connecting part 411213, wherein one transmission part 411212 is provided at the output end of the first drive motor 411211, the two transmission parts 411212 are spaced apart along the second direction, and the connecting part 411213 is connected to the two transmission parts 411212; the transmission parts 411212 may be gears or synchronous wheels, and the connecting part 411213 may be a chain or a synchronous toothed belt; when the transmission parts 411212 are gears, the connecting part 411213 is a chain; when the transmission parts 411212 are synchronous wheels, the connecting part 411213 is a synchronous toothed belt. Alternatively, the first drive member 41121 may include a third drive motor, a screw rod 4312, or a nut seat 4313, one end of the screw rod 4312 is connected to the third drive motor, and the nut seat 4313 is threadedly engaged with the screw rod 4312. The first sliding member 41122 and the second sliding member 4122 may include a guide rail and a slider. Alternatively, the first sliding member 41122 and the second sliding member 4122 may include an optical axis and a linear bearing.

[0065] In the present utility model, the first driving member 41121 of a second linear motion component 431 includes a first driving motor 411211, two transmission parts 411212 and a connecting part 411213, and the first driving member 41121 of another second linear motion component 431 includes a first driving motor 411211, two transmission parts 411212 and a connecting part 411213.

[0066] According to this embodiment, the second linear motion component 431 provides power so that the light source 31 and the microscope camera 32 move toward or away from each other along the third direction, thereby being able to adjust the distance between the light source 31 and the microscope camera 32 to adapt to the number of layers of the cell factory, thereby ensuring accurate detection results.

[0067] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A cell factory microscopic detection instrument, characterized in that: include: A frame (10) having a receiving cavity and two through-holes (11), wherein the two through-holes (11) are both communicated with the receiving cavity, and the two through-holes (11) are spaced apart along a first direction; A cell factory clamp (20) is provided on the frame (10), and the cell factory clamp (20) is used to clamp the cell factory; An imaging assembly (30) includes a light source (31) and a microscopic camera (32), wherein the light source (31) and the microscopic camera (32) are spaced apart along a first direction, and the light source (31) and the microscopic camera (32) have an original position and a working position; A moving assembly (40) is provided in the accommodating cavity. The moving assembly (40) includes a first moving device (41) and two second moving devices (42). The two second moving devices (42) are spaced apart along the first direction. The two second moving devices (42) are both provided on the first moving device (41). The light source (31) and the microscope camera (32) are provided on the second moving device (42) in a one-to-one correspondence. The first moving device (41) is used to drive the light source (31) and the microscope camera (32) to move along the second direction. The second moving device (42) is used to drive the light source (31) and the microscope camera (32) to switch between the original position and the working position.

2. The cell factory microscopic detection instrument according to claim 1, characterized in that: The frame (10) is provided with a flip door (12) corresponding to each of the through openings (11).

3. The cell factory microscopic detection instrument according to claim 1, characterized in that: At least two pairs of support members (13) are provided on the frame (10).

4. The cell factory microscopic detection instrument according to claim 1, characterized in that: The frame (10) is provided with a shutter (14).

5. The cell factory microscopic detection instrument according to any one of claims 1 to 4, characterized in that: The first moving device (41) includes a first driving mechanism (411), a supporting assembly (412) and a third connecting plate (413); the first driving mechanism (411) includes a first connecting plate (4111) and a first linear motion assembly (4112); the first linear motion assembly (4112) is arranged on the first connecting plate (4111); the supporting assembly (412) includes a second connecting plate (4121) and at least one second sliding member (4122); at least one second sliding member (4122) is arranged on the third connecting plate (413); and the third connecting plate (413) is connected to the first linear motion assembly (4112) and the second sliding member (4122).

6. The cell factory microscopic detection instrument according to claim 5, characterized in that: The second moving device (42) includes a moving plate (421), a mounting frame (422), a second driving member (423) and a third sliding member (424); the mounting frame (422) is arranged at one end of the moving plate (421) close to the through-hole (11); the second driving member (423) and the third sliding member (424) are both connected to the third connecting plate (413) and the moving plate (421).

7. The cell factory microscopic detection instrument according to claim 6, characterized in that: The second moving device (42) includes a shell (425), the shell (425) is connected to the third connecting plate (413), the moving plate (421), the second driving member (423) and the third sliding member (424) are all located in the shell (425), and the shell (425) is provided with an opening for the movement of the moving plate (421).

8. The cell factory microscopic detection instrument according to claim 7, characterized in that: The moving assembly (40) includes two third moving devices (43), both of which are arranged on a side of the third connecting plate (413) away from the first driving mechanism (411), and the two third moving devices (43) are arranged at intervals along the first direction. The third moving device (43) includes a second linear motion component (431) and a connecting frame (432), the connecting frame (432) is arranged on the second linear motion component (431), the second driving member (423) and the third sliding member (424) are both connected to the connecting frame (432) and the moving plate (421), and the housing (425) is connected to the connecting frame (432).

9. The cell factory microscopic detection instrument according to claim 8, characterized in that: The first linear motion assembly (4112) and the second linear motion assembly (431) include a first driving member (41121) and at least one pair of first sliding members (41122), and each pair of first sliding members (41122) is axially symmetrical about the central axis of the first driving member (41121).

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