Magnet support for immunity analyzer

Abstract

The magnet support for the immunoassay analyzer comprises an arc-shaped magnet and a base, the magnet is connected above the base, the magnet support further comprises an adjusting mechanism, the adjusting mechanism can adjust the magnet to move along a path S and determine the relative position, and the path S passes through the circle center and the midpoint of the magnet. By utilizing the magnet bracket provided by the utility model, the distance between the magnet and the reaction cup can be conveniently adjusted, so that the magnetic flux can be adjusted, the adjustment of the magnetic flux is uniformly changed due to the adjustment path of the magnet, and the reaction cup always keeps the same distance with the magnet in the rotating process.

Description

Technical Field

[0001] The utility model relates to the technical field of immunoassay analyzers in medical equipment, in particular to a magnet bracket for immunoassay analyzers. Background Art

[0002] Chemiluminescent immunoassays, also known as chemiluminescent immunoassays (CLIA), are immunoassays that directly label antigens or antibodies with a chemiluminescent reagent. A chemiluminescent immunoassay instrument consists of two components: an immunoreaction system and a chemiluminescent analysis system. The immunoreaction system directly labels the antigen (in chemiluminescent immunoassays) or antibody (in immunochemiluminescent assays) with a luminescent substance (which generates an excited intermediate upon excitation by the reagent), or involves an enzyme acting on a luminescent substrate.

[0003] In an immunoassay analyzer, when cleaning the reaction cup, it is necessary to use a magnetic field to adsorb the magnetic bead reagent in the reaction cup, and then allow the magnetic bead reagent to be adsorbed to the inner wall of the reaction cup. At this time, when the cleaning probe is inserted into the reaction cup for cleaning, the magnetic bead reagent can be prevented from being sucked away. In the incubation and cleaning tray of the immunoassay analyzer, multiple reaction cups are arranged in a circular shape on a rotatable tray. As the tray rotates, the reaction cups also rotate. At this time, a magnetic device is set on the side wall or bottom of the incubation and cleaning tray near the rotation track of the reaction cup. When the reaction cup rotates to the vicinity of the magnetic device, the magnetic bead reagent in the reaction cup can be adsorbed to its tube wall under the action of the magnetic field. In order to make the adsorption process as fast and thorough as possible during the adsorption process, it is necessary to adjust the magnetic flux of the magnetic device to a certain extent.

[0004] A search revealed that there are technical solutions for magnetic devices in immunoassay analyzers in the prior art, such as the utility model patent publication document with publication number "CN203764601U" and titled "A Magnetic Microsphere Cleaning Device for Fully Automatic Chemiluminescence Immunoassay." This document discloses a magnetic microsphere cleaning device for a fully automatic chemiluminescence immunoassay, comprising: an outer ring with a plurality of reaction cups arranged at intervals around it, in which magnetic microspheres for adsorbing samples to be tested are placed; an inner ring coaxially arranged on the inner side of the outer ring and having a permanent magnet on one side; a dislocation mechanism; an electromagnet located on one side of the outer ring, the electromagnet opposing at least one of the plurality of reaction cups on the outer ring; a cleaning element located above the outer ring and opposing at least one of the plurality of reaction cups on the outer ring; and a controller for controlling the on / off power supply and dislocation mechanism of the electromagnet. In the technical solution disclosed in this comparative document, the source of the magnetic field is an electromagnet, which can be controlled in a timely manner. However, the present application intends to use a permanent magnet and control the magnetic flux by adjusting the distance between the permanent magnet and the reaction cup. The two concepts are different but both can theoretically achieve corresponding technical effects.

[0005] A utility model patent publication with publication number "CN220215260U" and titled "Immunoanalyzer and Its Magnetic Separation Structure" discloses an immunoassay analyzer and its magnetic separation structure. The magnetic separation structure includes a first magnet unit and a second magnet unit. The second magnet unit is arranged along the periphery of the first magnet unit, forming a channel between the first magnet unit and the second magnet unit for the reaction cup to pass through. The first magnet unit includes at least two layers of inner magnets, both of which are arranged radially with opposite magnetic poles on the outer ring. The second magnet unit includes at least two layers of outer magnets, both of which are arranged radially with opposite magnetic poles on the inner ring. This reference document differs from the aforementioned reference documents in that it proposes a solution using permanent magnets as the source of the magnetic field, but does not propose a corresponding design solution for its adjustment mechanism.

[0006] Therefore, it is of great significance to propose a magnet bracket for an immunoassay analyzer in the art for adjusting the magnetic flux of an adsorption reaction cup. Utility Model Content

[0007] In response to the shortcomings of the existing technology, the present invention provides a magnet bracket for an immunoassay analyzer, comprising an arc-shaped magnet and a base, wherein the magnet is connected above the base, and further comprising an adjustment mechanism, wherein the adjustment mechanism can adjust the magnet to move along a path S and determine the relative position, wherein the path S passes through the center and midpoint of the magnet.

[0008] Furthermore, it also includes an arc-shaped connecting plate, with waist holes opened at both ends of the connecting plate, and the waist line L of the waist hole is parallel to the path S; threaded holes are opened at both ends of the base to match the position of the waist hole; the magnet is adsorbed on the lower surface of the connecting plate, and a bolt passes through the waist hole and then connects the magnet to the top of the base through the threaded hole, and the base is a non-magnetic body.

[0009] Furthermore, a receiving groove matching the magnet is provided on the base.

[0010] Furthermore, the lower surface of the connecting plate is also vertically connected to the baffle, and the curvature of the baffle matches the magnet.

[0011] Alternatively, the upper half of the base is magnetic and the lower half is non-magnetic, the magnet is adsorbed on the upper surface of the base, and waist holes 2 are opened at both ends of the base, and the waist line L of the waist hole 2 is parallel to the path S.

[0012] Alternatively, it also includes an arc-shaped connecting plate, the magnet is adsorbed on the lower surface of the connecting plate, and there are protrusions on the lower surfaces of both ends of the connecting plate. Both ends of the base have grooves that match the protrusions, the depth of the groove is greater than the protrusion, and the extension direction of the groove is parallel to the path S; a second threaded hole is provided on the protrusion, and the rear end face of the second bolt passing through the second threaded hole can contact the groove.

[0013] Alternatively, it also includes an arc-shaped connecting plate, with several circular holes opened at both ends of the connecting plate, and the center connection path S of the circular holes is parallel; threaded holes matching the circular holes are opened at both ends of the base; the magnet is adsorbed on the lower surface of the connecting plate, and the bolt passes through the circular hole and then connects the magnet to the top of the base through the threaded hole, and the base is a non-magnetic conductive body.

[0014] Compared with the prior art, the technical solution of the present application has the following beneficial effects: using the magnet bracket proposed in the present invention, the distance between the magnet and the reaction cup can be easily adjusted, thereby adjusting the magnetic flux, and the adjustment path of the magnet makes the adjustment of the magnetic flux change evenly, and the reaction cup always maintains the same distance from the magnet during rotation. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 : Schematic diagram of the overall structure of the magnet bracket provided in Example 1 of the present utility model;

[0016] Figure 2 : Schematic diagram of the dispersed structure of the magnet bracket provided in Example 1 of the present utility model;

[0017] Figure 3 : A top view of the magnet bracket provided in Example 1 of the present invention;

[0018] Figure 4 : Schematic diagram of the overall structure of the magnet bracket provided in Example 2 of the present utility model;

[0019] Figure 5 : A cross-sectional view of the connecting plate and one end of the base in the magnet bracket provided in the third embodiment of the present invention;

[0020] Figure 6 : Top view of the magnet bracket provided in Example 4 of the present invention. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0022] A magnet bracket for an immunoassay analyzer includes an arc-shaped magnet 1 and a base 2. The magnet 1 is connected above the base 2 and also includes an adjustment mechanism. The adjustment mechanism can adjust the movement of the magnet 1 along a path S and determine the relative position. The path S passes through the center and midpoint of the magnet 1.

[0023] The above is the basic structural design of the magnet holder. Under the adjustment of the adjustment mechanism, the magnet 1 can be ensured to move along path S. Once any position on this path is determined, since the reaction cup also moves in a circular motion about the center of the arc-shaped magnet 1, the distance between the reaction cup and magnet 1 after passing near the magnet 1 during the adjustment process is consistent, so that the reaction cup can be subjected to a consistent adsorption force during the rotation process. Obviously, the arc-shaped design of the magnet 1 is inevitable, but the base 2 as a support device does not necessarily need to be designed as an arc. However, in this embodiment, the same arc-shaped design is preferably used to save more space during installation.

[0024] Example 1: Figures 1 to 3 shown.

[0025] It also includes an arc-shaped connecting plate 3, with waist holes 4 formed at both ends of the connecting plate 3, and the waist line L of the waist hole 4 is parallel to the path S; threaded holes 5 are formed at both ends of the base 2 to match the position of the waist hole 4; the magnet 1 is adsorbed on the lower surface of the connecting plate 3, and a bolt 6 passes through the waist hole 4 and then connects the magnet 1 to the top of the base 2 through the threaded hole 5, and the base 2 is a non-magnetic conductive body.

[0026] In this embodiment, magnet 1 is fixed to the lower surface of connecting plate 3 using its own magnetism. Since base 2 is non-magnetic, there is no magnetic force between magnet 1 and base 2 to constrain their position. When the position of magnet 1 needs to be adjusted, bolt 1 (6) can be loosened and connecting plate 3 can be pushed. Since the opening direction of waist hole 1 (4) is limited, the movement path of connecting plate 3 is strictly limited to path S, ensuring that the distance between magnet 1 and the cuvette during rotation is consistent during the position adjustment process. After determining the position of magnet 1, bolt 1 (6) can be re-tightened.

[0027] In a more preferred embodiment, the base 2 is provided with a receiving groove 21 that matches the magnet 1. The arrangement of the receiving groove 21 allows the magnet 1 to be embedded in the upper surface of the base 2, with its ends blocked by the receiving groove 21. Since the base 2 is a non-magnetic material, the outward magnetic field at both ends of the magnet can be isolated.

[0028] In a more preferred embodiment, the lower surface of the connecting plate 3 is also perpendicularly connected to a baffle 31, the curvature of which matches the magnet 1. In this embodiment, the baffle 31 can be magnetically conductive, so that the magnet 1 is simultaneously attracted to the baffle 31 and the inner surface of the connecting plate 3, securing it more securely. Alternatively, it can be non-magnetic, in which case the baffle 31 does not secure the magnet 1 but instead acts as a magnetic field shield, isolating the magnetic field outside the magnet 1.

[0029] Example 2: Figure 4 shown.

[0030] The upper half of the base 2 is magnetic and the lower half is non-magnetic. The magnet 1 is adsorbed on the upper surface of the base 2. The two ends of the base 2 are provided with waist holes 7. The waist line L of the waist hole 7 is parallel to the path S.

[0031] Different from Example 1, the design of the connecting plate 3 is omitted in this embodiment. The base 2 is directly used as the part for fixing the magnet 1. The structure of the waist hole 2 7 and the waist hole 1 4 on the connecting plate 3 in Example 1 is consistent, except that the two ends of the base 2 in this embodiment need to cooperate with bolts and external components that support the base 2 to achieve the overall position adjustment of the base 2 and the magnet 1. In this embodiment, the upper half of the base 2 is magnetic and the lower half is non-magnetic, and the base 2 can be moved more conveniently when it is installed on the external component after carrying the magnet 1. The external component can be the bottom surface of the incubation and cleaning tray that accommodates the reaction cup.

[0032] Example 3: Figure 5 shown.

[0033] It includes an arc-shaped connecting plate 3, a magnet 1 is adsorbed on the lower surface of the connecting plate 3, and the lower surfaces of both ends of the connecting plate 3 have protrusions 32. The two ends of the base 2 have grooves 22 that match the protrusions 32. The depth of the groove 22 is greater than that of the protrusion 32, and the extension direction of the groove 22 is parallel to the path S; a second threaded hole 321 is opened on the protrusion 32, and the rear end surface of the second bolt 322 passing through the second threaded hole 321 can contact the groove 22.

[0034] This embodiment differs from the first embodiment in that the adjustment mechanism utilizes a projection 32 and a groove 22 in place of the first waist hole 4. Since the groove 22 extends parallel to the path S, the adjustment process for magnet 1 can achieve the same technical effect as in the first embodiment. To adjust, simply loosen bolt 2 322, determine the position of magnet 1, and then tighten bolt 2 322 until it contacts and tightens against the bottom surface of groove 22, thereby securing magnet 1 in place.

[0035] Example 4: Figure 6 shown.

[0036] It includes an arc-shaped connecting plate 3, with several circular holes 41 formed at both ends of the connecting plate 3, and the center connection path S of the circular holes 41 is parallel; threaded holes 5 are formed at both ends of the base 2 to match the circular holes 41; the magnet 1 is adsorbed on the lower surface of the connecting plate 3, and a bolt 6 passes through the circular hole 41 and then connects the magnet 1 to the top of the base 2 through the threaded hole 5, and the base 2 is a non-magnetic conductive body.

[0037] In Examples 1 to 3, the position adjustment of the magnet 1 is continuously adjustable, so that the magnetic flux between the magnet 1 and the reaction cup can be adjusted more accurately. However, in some cases, continuous adjustment is not required, but the position of the magnet 1 needs to be determined to a number of precise positions. After the accurate position is determined, the specific magnetic flux at the position can be obtained by detection. When it is necessary to adjust to the magnetic flux, it is only necessary to adjust the position of the magnet 1 to the determined position. Although this adjustment method is not continuously adjustable, it is very convenient to adjust the magnet 1 to the position of the required magnetic flux. Obviously, the independent circular hole 41 corresponds to the corresponding specific adjustment position. The number of single-end circular holes 41 can be determined based on the width of the connecting plate 3 and the specific adjustment gear of the magnetic flux. In this example, it is determined to be three single-end. In this embodiment, the position adjustment of the magnet 1 is determined to be a three-gear adjustment. When making specific adjustments, it is only necessary to completely loosen the bolt 6, push the connecting plate 3 so that the circular hole 41 of the corresponding gear corresponds to the threaded hole 5, and then tighten the bolt 6.

[0038] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply the existence of any such actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article, or device comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or device. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of other identical elements in the process, method, article, or device comprising the element.

[0039] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A magnet holder for an immunoassay analyzer, characterized in that: The invention comprises an arc-shaped magnet (1) and a base (2), wherein the magnet (1) is connected above the base (2), and further comprises an adjustment mechanism, wherein the adjustment mechanism can adjust the magnet (1) to move along a path S and determine the relative position, wherein the path S passes through the center and midpoint of the magnet (1).

2. The magnet holder for an immune analyzer according to claim 1, wherein: The invention also includes an arc-shaped connecting plate (3), with waist holes (4) formed at both ends of the connecting plate (3), and a waist line L of the waist hole (4) being parallel to the path S; a threaded hole (5) matching the position of the waist hole (4) is formed at both ends of the base (2); a magnet (1) is adsorbed on the lower surface of the connecting plate (3), and a bolt (6) passes through the waist hole (4) and then connects the magnet (1) to the top of the base (2) through the threaded hole (5), wherein the base (2) is a non-magnetic conductive body.

3. The magnet holder for an immune analyzer according to claim 2, wherein: The base (2) is provided with a receiving groove (21) that matches the magnet (1).

4. The magnet holder for an immune analyzer according to claim 3, wherein: The lower surface of the connecting plate (3) is also vertically connected to the baffle (31), and the curvature of the baffle (31) matches that of the magnet (1).

5. The magnet holder for an immune analyzer according to claim 1, wherein: The upper half of the base (2) is magnetic and the lower half is non-magnetic. The magnet (1) is adsorbed on the upper surface of the base (2). Two waist holes (7) are provided at both ends of the base (2). The waist line L of the second waist hole (7) is parallel to the path S.

6. The magnet holder for an immune analyzer according to claim 1, wherein: The invention also includes an arc-shaped connecting plate (3), wherein the magnet (1) is adsorbed on the lower surface of the connecting plate (3), and the lower surfaces of both ends of the connecting plate (3) have protrusions (32). Both ends of the base (2) have grooves (22) matching the protrusions (32), the depth of the grooves (22) is greater than that of the protrusions (32), and the extending direction of the grooves (22) is parallel to the path S; the protrusion (32) is provided with a second threaded hole (321) passing through the second threaded hole (321), and the rear end surface of the second bolt (322) passing through the second threaded hole (321) can contact the groove (22).

7. The magnet holder for an immune analyzer according to claim 1, wherein: The invention also includes an arc-shaped connecting plate (3), wherein a plurality of circular holes (41) are provided at both ends of the connecting plate (3), and the center-line path S of the circular holes (41) is parallel; threaded holes (5) matching the circular holes (41) are provided at both ends of the base (2); the magnet (1) is adsorbed on the lower surface of the connecting plate (3), and a bolt (6) passes through the circular hole (41) and then connects the magnet (1) to the top of the base (2) through the threaded hole (5), wherein the base (2) is a non-magnetic conductive body.

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