CircRNA (Ribonucleic Acid) stock solution encapsulating device

By designing a circRNA stock solution encapsulation device, the automated and continuous production of the circRNA stock solution encapsulation process is achieved, and the problems of inefficient efficiency and insufficient equipment applicability in the existing technology are solved, and the packaging quality and equipment applicability are improved.

CN223267085UActive Publication Date: 2025-08-26FUZHOU XINCHEN SUPPLY CHAIN TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202422766098.3
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-11-13
Publication Date
2025-08-26
Estimated Expiration
2034-11-13

AI Technical Summary

Technical Problem

The existing circRNA stock solution packaging process relies on manual operation, is inefficient and easily affects the packaging quality due to improper operation. The existing equipment cannot adapt to filling tubes of different sizes and types, limiting the flexibility and scope of application of the equipment.

Method used

A circuitRNA raw liquid encapsulation device is designed, including an electric rotating table, filling mechanism, ultrasonic tail sealing mechanism and feeding mechanism. The automatic assembly line is realized through the electric rotating table, the filling mechanism ensures accurate positioning, the ultrasonic tail sealing mechanism provides good sealing effect, and the cutting mechanism realizes automatic feeding, adapting to filling pipes of different sizes.

Benefits of technology

The automatic and continuous production of the circRNA stock solution packaging process is realized, which improves production efficiency, ensures packaging quality and equipment flexibility, reduces operating errors and contamination risks, and improves product stability and purity.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model relates to the technical field of circRNA (Ribonucleic Acid) stock solution packaging, and discloses a circRNA stock solution packaging device which comprises a packaging table, a filling mechanism, an ultrasonic tail sealing mechanism and a discharging mechanism, an electric rotating table on the packaging table is provided with a positioning seat for positioning and inserting four filling pipes; a filling nozzle on the filling mechanism is pushed by an air cylinder A to move downwards to extend into a filling pipe, two positioning plates on the filling mechanism clamp and position the filling pipe when the filling pipe is used for filling, and two tool heads on the ultrasonic tail sealing mechanism transmit ultrasonic vibration generated by an ultrasonic transducer to a pipe opening of the filling pipe. The two tool heads are pushed by the two-way air cylinder to apply proper pressure from the two sides of the filling pipe so as to seal the pipe opening of the filling pipe; a splayed clamping jaw on the discharging mechanism is pushed by an air cylinder B to clamp, fix or loosen the filling pipe, the whole circRNA stock solution encapsulating device can automatically conduct filling, end sealing and discharging, and automatic circRNA stock solution encapsulating operation is achieved.
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Description

Technical Field

[0001] The utility model belongs to the technical field of circRNA stock solution packaging, and specifically relates to a circRNA stock solution encapsulation device. Background Art

[0002] With the advancement of biotechnology, circRNA (circular RNA), as an emerging biomolecule, holds broad application prospects in medical research and treatment. The encapsulation of circRNA bulk solutions is a critical step in the production of circRNA products, and its quality is directly related to the safety and efficacy of the products. Traditional circRNA bulk solution encapsulation processes often rely on manual labor, which is not only inefficient but also prone to contamination and encapsulation quality issues due to improper operation.

[0003] The traditional packaging process involves manual intervention in the steps of loading, filling, sealing, and unloading, which are cumbersome and time-consuming, and cannot meet the needs of large-scale production. Problems such as inaccurate positioning, unstable filling, and loose sealing are prone to occur during manual operation, which can affect packaging quality and even lead to product scrapping. Due to the uncontrollable nature of manual operation, environmental contaminants can easily enter the filling tube, affecting the purity and activity of the circRNA stock solution. Existing packaging equipment is often unable to adapt to filling tubes of different sizes and types, limiting the equipment's flexibility and scope of application.

[0004] In view of this, we proposed a circRNA stock solution encapsulation device. Utility Model Content

[0005] The present invention aims to solve the technical problem that the circRNA stock solution encapsulation process in the above-mentioned prior art usually relies on manual operation, which is not only inefficient but also easily affects the encapsulation quality due to improper operation.

[0006] To achieve the above objectives, the present invention provides the following technical solutions:

[0007] A circRNA stock solution encapsulation device, comprising:

[0008] The encapsulation table is equipped with an electric rotating table. Four positioning seats for positioning and inserting the filling tubes of the circRNA stock solution are arranged in a circular and equidistant manner on the rotating disk of the electric rotating table;

[0009] Filling mechanism: The filling nozzle on the filling mechanism is pushed down by cylinder A and extends into the filling tube. The two positioning plates on the filling mechanism clamp and position the filling tube during filling. The positioning plates are driven up and down by the vertical servo linear module on the filling mechanism for height adjustment.

[0010] Ultrasonic sealing mechanism: The two tool heads on the ultrasonic sealing mechanism transmit the ultrasonic vibration generated by the ultrasonic transducer to the tube mouth of the filling tube. The two tool heads are pushed by the bidirectional cylinder to apply appropriate pressure from both sides of the filling tube to achieve the sealing of the filling tube mouth;

[0011] The unloading mechanism has an eight-shaped clamping jaw which is pushed by cylinder B to clamp or release the filling tube. The horizontal servo linear module on the unloading mechanism drives the eight-shaped clamping jaw to move and transfer the clamped filling tube to unload.

[0012] The electric rotary table enables the four filling tubes to be automatically positioned in sequence. Combined with the filling mechanism, it enables an automated, continuous production process, greatly improving production efficiency. The combination of the filling tubes and the positioning seat ensures precise positioning during the filling process, reduces filling errors, and improves the packaging quality of the product. The positioning plate is driven by a vertical servo linear module and can be adjusted in height to accommodate filling tubes of different sizes, enhancing the device's applicability and flexibility. Using an ultrasonic sealing machine, which provides excellent sealing results, the entire circRNA bulk solution encapsulation device can automatically perform filling, sealing, and unloading, achieving automated circRNA bulk solution encapsulation operations.

[0013] Preferably, the four positioning seats on the rotating disc are aligned with the loading station, filling station, tail sealing station, and unloading station respectively. The filling mechanism is aligned with the filling station, the ultrasonic tail sealing mechanism is aligned with the tail sealing station, and the unloading mechanism is aligned with the unloading station. This design clearly divides the functions of each station, allowing workers to clearly understand each step, thereby reducing the possibility of operational errors.

[0014] Preferably, a plurality of insertion holes for fitting the filling tube for positioning are arranged at equal distances on the positioning seat.

[0015] The design of the plug hole enables the filling tube to be aligned and positioned quickly and accurately, reducing adjustment time and improving production efficiency.

[0016] Preferably, the filling mechanism further comprises an upper mounting plate and a lower mounting plate fixed on the movable slide of the vertical servo linear module, and a lifting plate fixed to the end of the piston rod of the cylinder A and fixing the filling tube; the vertical servo linear module is fixed to the first bracket on one side of the packaging table;

[0017] The two positioning plates are pushed by two cylinders C fixed at the bottom of the lower mounting plate to move closer together to clamp the filling tube or away from each other to release the filling tube; the positioning plates are provided with concave grooves for clamping and positioning the filling tube; the lower mounting plate is provided with insertion holes A for the exposed filling tube to pass through.

[0018] The upper and lower mounting plates are precisely controlled by a vertical servo linear module's sliding slide, ensuring accurate alignment of the filling nozzle with the filling tube, improving filling accuracy. The two positioning plates, driven by cylinder C, move toward or away from each other, firmly clamping and releasing the filling tube, preventing displacement during the filling process.

[0019] Preferably, a guide rod is fixed between the upper mounting plate and the L-shaped support plate at the bottom of the lower mounting plate to cooperate with the lifting plate to slide and guide the lifting, and a through hole B is opened on the lower mounting plate to cooperate with the guide rod to penetrate, ensuring that the vertical movement of the lifting plate is more stable and accurate.

[0020] Preferably, the ultrasonic sealing mechanism also includes two mounting seats for fixing the two tool heads respectively, a mounting block arranged between the two mounting seats, and a cylinder D. The cylinder D is fixed on the second bracket on the top of the packaging table. The piston rod end of the cylinder D is fixedly connected to the mounting block. The bidirectional cylinder is embedded in the mounting block. The mounting block is provided with a guide groove for guiding the sliding in coordination with the guide blocks on the two mounting seats.

[0021] The setting of cylinder D enables the mounting block to precisely control the movement of the bidirectional cylinder, thereby ensuring that the ultrasonic tool head can apply appropriate pressure to seal the tail and improve the sealing quality.

[0022] Preferably, the unloading mechanism also includes a cylinder E, which is fixed to the horizontally movable base of the horizontal servo linear module. The end of the piston rod of cylinder E is fixedly connected to the rectangular mounting frame on which the splayed jaws are mounted. Cylinder B is mounted inside the rectangular mounting frame and pushes the splayed jaws to open or close. The horizontal servo linear module is fixed to the third bracket of the packaging table. The combination of cylinder E and the horizontal servo linear module enables automatic unloading of filling tubes, reducing the need for manual operation.

[0023] Compared with existing technologies, the technical effects and advantages of this utility model are as follows: By designing a motorized rotary table and automating each workstation, the circRNA bulk solution encapsulation device achieves automation and continuity of the encapsulation process, significantly improving production efficiency. The positioning base on the rotating disc clearly demarcates the loading, filling, sealing, and unloading stations, reducing the possibility of operational errors. The use of a plug-in hole and positioning plate design enables rapid and accurate positioning of the filling tube on the positioning base, reducing the risk of leakage and contamination.

[0024] Driven by a vertical servo linear module and with height adjustment of the positioning plate, the machine can adapt to filling tubes of different sizes, enhancing its applicability and flexibility. Ultrasonic sealing technology provides excellent sealing results and improves product quality.

[0025] In summary, the circRNA stock solution encapsulation device proposed above effectively solves the defects of the existing technology by integrating automation, precise control and high adaptability, improves production efficiency, ensures product quality, and provides a more reliable and efficient technical solution for the encapsulation of circRNA stock solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a structural diagram of the utility model;

[0027] Figure 2 This is a first perspective view of the filling mechanism of the present invention.

[0028] Figure 3 This is a second perspective view of the filling mechanism of the present invention;

[0029] Figure 4 This is a schematic structural diagram of the ultrasonic tail sealing mechanism of the utility model;

[0030] Figure 5 This is a structural diagram of the blanking mechanism of the utility model;

[0031] Figure 6 It is a structural schematic diagram of the positioning seat of the utility model.

[0032] Figure: 1, packaging table; 2, electric rotary table; 3, rotating disc; 4, filling tube; 5, positioning seat; 501, plug hole; 6, filling mechanism; 601, cylinder A; 602, filling nozzle; 603, positioning plate; 604, vertical servo linear module; 605, moving slide; 606, upper mounting plate; 607, lower mounting plate; 608, lifting plate; 609, cylinder C; 610, insertion hole A; 611, L-shaped support plate; 612, guide rod; 613, insertion hole B; 6 14. First bracket; 615. Concave groove; 7. Ultrasonic sealing mechanism; 701. Tool head; 702. Bidirectional cylinder; 703. Mounting seat; 704. Mounting block; 705. Cylinder D; 706. Second bracket; 707. Guide block; 708. Guide groove; 8. Unloading mechanism; 801. Figure-eight clamp; 802. Cylinder B; 803. Horizontal servo linear module; 804. Cylinder E; 805. Horizontal moving seat; 806. Rectangular mounting frame; 807. Third bracket. DETAILED DESCRIPTION

[0033] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0034] The following is combined with Figure 1-6 To further explain this application,

[0035] The present application embodiment discloses a circRNA stock solution encapsulation device, comprising an encapsulation station 1, a filling mechanism 6, an ultrasonic sealing mechanism 7, and a feeding mechanism 8;

[0036] The encapsulation table 1 is equipped with an electric rotating table 2. On the rotating disk 3 of the electric rotating table 2, four locating seats 5 for positioning and inserting filling tubes 4 for circRNA stock solution are arranged in a circular pattern at equal distances.

[0037] The four positioning seats 5 on the rotating disc 3 are respectively aligned with the loading station, filling station, tail sealing station and unloading station, the filling mechanism 6 is aligned with the filling station, the ultrasonic tail sealing mechanism 7 is aligned with the tail sealing station, and the unloading mechanism 8 is aligned with the unloading station. This design clearly divides the functions of each station, allowing staff to clearly understand each step, thereby reducing the possibility of operational errors. This layout helps to form an automated assembly line, with each station focusing on its specific task, improving overall production efficiency. Because the stations are fixed and highly automated, human intervention can be reduced and errors caused by improper operation can be reduced. The specialized operation of each station helps to ensure the packaging quality of the circRNA stock solution and reduce the risk of contamination and damage. The operator loads the filling tube 4 from the loading station and transfers it to the filling station under the action of the electric rotating table 2.

[0038] The positioning base 5 is provided with a number of equally spaced insertion holes 501 for aligning and positioning the filling tube 4. The design of the insertion holes 501 allows for quick and accurate alignment of the filling tube 4, reducing adjustment time and improving production efficiency. The insertion holes 501 ensure the stability of the filling tube 4 on the positioning base 5, preventing leakage or contamination caused by shaking during the filling process. The operator simply inserts the filling tube 4 into the corresponding insertion hole 501 to complete positioning, simplifying the operation and reducing difficulty.

[0039] The filling nozzle 602 on the filling mechanism 6 is pushed down by the cylinder A601 and extends into the filling tube 4. The two positioning plates 603 on the filling mechanism 6 clamp and position the filling tube 4 during filling. The positioning plates 603 are driven up and down by the vertical servo linear module 604 on the filling mechanism 6 for height adjustment.

[0040] The filling mechanism 6 also includes an upper mounting plate 606 and a lower mounting plate 607 fixed to the movable slide 605 of the vertical servo linear module 604, and a lifting plate 608 fixed to the end of the piston rod of the cylinder A601 and fixing the filling tube 4; the vertical servo linear module 604 is fixed to the first bracket 614 on one side of the packaging table 1;

[0041] The two positioning plates 603 are pushed relatively close to each other to clamp the filling tube 4 or pushed away from each other to loosen the filling tube 4 by two cylinders C609 fixed at the bottom of the lower mounting plate 607; the positioning plates 603 are provided with concave grooves 615 for clamping and positioning the filling tube 4; the lower mounting plate 607 is provided with insertion holes A610 for the exposed insertion of the filling tube 4.

[0042] The upper and lower mounting plates 606 and 607 are precisely controlled by the movable slide 605 of the vertical servo linear module 604, ensuring that the filling nozzle 602 is accurately aligned with the filling tube 4, thereby improving filling accuracy. The two positioning plates 603 are pushed toward or away from each other by the cylinder C609, enabling secure clamping and release of the filling tube 4 and preventing displacement of the filling tube 4 during the filling process. The concave groove 615 on the positioning plate 603 matches the shape of the filling tube 4, allowing the filling tube 4 to be quickly positioned and securely clamped, improving clamping efficiency. The insertion hole A610 on the lower mounting plate 607 corresponds to the exposed portion of the filling tube 4, helping the filling nozzle 602 to accurately align, insert, or remove from the filling tube 4, reducing operational errors.

[0043] A guide rod 612 is fixed between the upper mounting plate 606 and the L-shaped support plate 611 at the bottom of the lower mounting plate 607 to cooperate with the lifting plate 608 in sliding and guiding the lifting. The lower mounting plate 607 is provided with an insertion hole B613 for the guide rod 612 to penetrate. The setting of the guide rod 612 provides additional guiding and positioning functions to ensure that the vertical movement of the lifting plate 608 is more stable and precise. The guide rod 612 slides in the insertion hole B613, reducing friction and wear during movement, and improving the durability and maintenance cycle of the equipment. The sliding guiding effect of the guide rod 612 makes the lifting plate 608 smoother during movement, reduces impact and vibration during movement, and improves the stability and repeatability of the filling process. The optimization of the overall design enhances the reliability of the filling mechanism 6, reduces the probability of failure, and improves production efficiency and product quality.

[0044] During operation, the vertical servo linear module 604 is actuated, driving the upper mounting plate 606 and the lower mounting plate 607 to move downward, and the insertion hole A610 is movably inserted into the outside of the filling tube 4. The cylinder C609 is actuated, driving the two positioning plates 603 to move relatively close to position and clamp the filling tube 4 on the positioning seat 5. The cylinder A601 pushes the filling nozzle 602 to move downward and accurately align and insert it into the inner side of the filling tube 4 to start the filling operation. After the filling is completed, the vertical servo linear module 604 is actuated, driving the upper mounting plate 606 and the lower mounting plate 607 to move upward, and the cylinder C609 is actuated to drive the two positioning plates 603 away from the filling tube 4. The vertical servo linear module 604 is actuated, driving the upper mounting plate 606 and the lower mounting plate 607 to move upward, and the electric rotary table 2 drives the positioning seat 5 and the filling tube 4 to be transferred to the tail sealing station.

[0045] The two tool heads 701 on the ultrasonic sealing mechanism 7 transmit the ultrasonic vibration generated by the ultrasonic transducer to the tube mouth of the filling tube 4. The two-way cylinder 702 pushes the two tool heads 701 to apply appropriate pressure from both sides of the filling tube 4 to seal the tube mouth of the filling tube 4.

[0046] The ultrasonic sealing mechanism 7 also includes two mounting seats 703 for fixing the two tool heads 701 respectively, a mounting block 704 arranged between the two mounting seats 703, and a cylinder D705. The cylinder D705 is fixed on the second bracket 706 on the top of the packaging table 1. The end of the piston rod of the cylinder D705 is fixedly connected to the mounting block 704. The bidirectional cylinder 702 is embedded in the mounting block 704. The mounting block 704 is provided with a guide groove 708 for guiding the sliding in cooperation with the guide blocks 707 on the two mounting seats 703.

[0047] The configuration of cylinder D705 enables mounting block 704 to move upward or downward. During this downward movement, the movement of bidirectional cylinder 702 is precisely controlled, ensuring that the ultrasonic tool head 701 applies appropriate pressure for sealing, thereby improving sealing quality. After sealing is completed, cylinder D705 moves away from the filling tube. The guide block 707 between mounting blocks 703 and the guide groove 708 on mounting block 704 provide stable guidance, ensuring smooth movement of tool head 701 during the sealing process and reducing vibration. The embedded installation of bidirectional cylinder 702 enables faster sealing, improving sealing efficiency and shortening production cycles.

[0048] The eight-shaped clamping jaw 801 on the blanking mechanism 8 is pushed by the cylinder B802 to clamp or release the filling tube 4. The horizontal servo linear module 803 on the blanking mechanism 8 drives the eight-shaped clamping jaw 801 to move and transfer the clamped filling tube 4 to be blanked.

[0049] The unloading mechanism 8 also includes a cylinder E804, which is fixed on the horizontal movable seat 805 of the horizontal servo linear module 803. The end of the piston rod of the cylinder E804 is fixedly connected to the rectangular mounting frame 806 on which the figure-eight clamp 801 is installed. The cylinder B802 is installed on the inner side of the rectangular mounting frame 806 and pushes the figure-eight clamp 801 to expand or close. The horizontal servo linear module 803 is fixed on the third bracket 807 of the packaging table 1.

[0050] The combined use of the air cylinder E804 and the horizontal servo linear module 803 enables the automatic unloading of the filling tube 4, reducing the need for manual operation. The horizontal servo linear module 803 provides precise movement control, ensuring the accurate position of the filling tube 4 during the transmission process and reducing errors. The air cylinder B802 is installed on the inside of the rectangular mounting frame 806, which can push the eight-shaped clamping jaws 801 to expand or close. This design enables the clamping jaws to flexibly handle filling tubes 4 of different sizes. Automated unloading reduces direct contact between operators and equipment, improving production safety. The design of the entire unloading mechanism 8 is integrated with the overall structure of the packaging table 1, making the production process more compact and efficient, saving space, and improving overall production efficiency.

[0051] During operation, the horizontal servo linear module 803 drives the horizontal moving seat 805 and the cylinder E804 to move left and right, switching the figure eight clamp 801 to the unloading station or the unloading station. The unloading station can be aligned with the unloading conveyor line to facilitate the transportation of the filling tube 4 after unloading. The cylinder E804 drives the figure eight clamp 801 to rise or fall. When descending, it cooperates with the action of the cylinder B802 to drive the figure eight clamp 801 to close and clamp the filling tube 4. Then the cylinder E804 drives the figure eight clamp 801 to rise, and cooperates with the action of the cylinder E804 to drive the figure eight clamp 801 to move to the right to the unloading station. The figure eight clamp 801 releases the filling tube 4 and unloads the filling tube 4 onto the unloading conveyor line.

[0052] This circRNA bulk solution encapsulation device uses a positioning seat on the rotating disc to clearly define the loading, filling, sealing, and unloading workstations. This allows workers to clearly understand each step and reduce the possibility of operational errors. Each workstation focuses on a specific task, forming an automated production line and improving overall production efficiency. The high degree of automation reduces errors caused by human intervention and improper operation. Specialized operation helps ensure the encapsulation quality of the circRNA bulk solution and reduces the risk of contamination and damage. The socket 501 on the positioning seat simplifies the positioning of the filling tube and improves production efficiency. The socket 501 ensures the stability of the filling tube on the positioning seat, preventing leakage or contamination caused by shaking. Precise control of the upper mounting plate 606 and the lower mounting plate 607 ensures that the filling nozzle 602 is accurately aligned with the filling tube 4, improving filling accuracy. The combination of the electric rotating table 2 and the filling mechanism 6 realizes an automated and continuous production process, greatly improving production efficiency. The combination of the filling tube 4 and the positioning seat 5 ensures precise positioning during the filling process, reducing filling errors. The height adjustment of positioning plate 603 accommodates filling tubes of varying sizes, enhancing the device's adaptability and flexibility. The ultrasonic sealing machine provides excellent sealing, improving product quality. The entire circRNA stock solution encapsulation device enables automated filling, sealing, and unloading, achieving automated operation.

[0053] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A circRNA stock solution encapsulation device, characterized in that: include: An encapsulation table (1) is provided with an electric rotating table (2) mounted on the encapsulation table (1), and a rotating disk (3) of the electric rotating table (2) is provided with four positioning seats (5) for positioning and plugging filling tubes (4) for matching circRNA stock solution arranged at equal intervals in a circular pattern; A filling mechanism (6), wherein a filling nozzle (602) on the filling mechanism (6) is pushed downward by a cylinder A (601) to extend into the filling tube (4), and two positioning plates (603) on the filling mechanism (6) clamp and position the filling tube (4) when the filling tube (4) is filled, and the positioning plates (603) are driven to rise and fall by a vertical servo linear module (604) on the filling mechanism (6) to adjust the height; An ultrasonic tail sealing mechanism (7), wherein two tool heads (701) on the ultrasonic tail sealing mechanism (7) transmit ultrasonic vibrations generated by an ultrasonic transducer to the mouth of the filling tube (4), and a bidirectional cylinder (702) pushes the two tool heads (701) to apply appropriate pressure from both sides of the filling tube (4) to seal the mouth of the filling tube (4); The unloading mechanism (8) comprises an eight-shaped clamping claw (801) on the unloading mechanism (8) which is pushed by the cylinder B (802) to clamp or release the filling tube (4). The horizontal servo linear module (803) on the unloading mechanism (8) drives the eight-shaped clamping claw (801) to move and transfer the clamped filling tube (4) for unloading.

2. A circRNA stock solution encapsulation device according to claim 1, characterized in that: The four positioning seats (5) on the rotating disc (3) are respectively aligned with the loading station, the filling station, the tail sealing station and the unloading station, the filling mechanism (6) is aligned with the filling station, the ultrasonic tail sealing mechanism (7) is aligned with the tail sealing station, and the unloading mechanism (8) is aligned with the unloading station.

3. A circRNA stock solution encapsulation device according to claim 1, characterized in that: A plurality of insertion holes (501) for inserting and positioning the filling tube (4) are arranged at equal intervals on the positioning seat (5).

4. A circRNA stock solution encapsulation device according to claim 1, characterized in that: The filling mechanism (6) further comprises an upper mounting plate (606) and a lower mounting plate (607) fixed on a movable slide (605) of a vertical servo linear module (604), and a lifting plate (608) fixed to the end of a piston rod on the cylinder A (601) and fixing the filling tube (4); the vertical servo linear module (604) is fixed on a first bracket (614) on one side of the packaging table (1); The two positioning plates (603) are pushed by two cylinders C (609) fixed at the bottom of the lower mounting plate (607) to move closer to each other to clamp the filling tube (4) or away from each other to release the filling tube (4); the positioning plates (603) are provided with concave grooves (615) for clamping and positioning the filling tube (4); and the lower mounting plate (607) is provided with insertion holes A (610) for inserting the exposed filling tube (4).

5. A circRNA stock solution encapsulation device according to claim 4, characterized in that: A guide rod (612) is fixedly provided between the upper mounting plate (606) and the L-shaped support plate (611) at the bottom of the lower mounting plate (607) to cooperate with the lifting plate (608) for sliding and guiding the lifting. The lower mounting plate (607) is provided with an insertion hole B (613) for the guide rod (612) to penetrate.

6. A circRNA stock solution encapsulation device according to claim 1, characterized in that: The ultrasonic sealing mechanism (7) further comprises two mounting seats (703) for respectively fixing the two tool heads (701), a mounting block (704) provided between the two mounting seats (703), and a cylinder D (705). The cylinder D (705) is fixed on a second bracket (706) on the top of the packaging table (1). The end of the piston rod of the cylinder D (705) is fixedly connected to the mounting block (704). The bidirectional cylinder (702) is embedded in the mounting block (704). The mounting block (704) is provided with a guide groove (708) for guiding the sliding of the guide blocks (707) on the two mounting seats (703).

7. A circRNA stock solution encapsulation device according to claim 1, characterized in that: The unloading mechanism (8) further comprises a cylinder E (804), which is fixed on a horizontal movable seat (805) of a horizontal servo linear module (803), and a piston rod end of the cylinder E (804) is fixedly connected to a rectangular mounting frame (806) on which an eight-shaped clamping jaw (801) is mounted. The cylinder B (802) is mounted on the inner side of the rectangular mounting frame (806) and pushes the eight-shaped clamping jaw (801) to expand or close. The horizontal servo linear module (803) is fixed on a third bracket (807) of the packaging table (1).