Chip platform

Abstract

The utility model provides a chip platform, and the chip platform comprises a chip carrying platform which is provided with at least one installation position; the pressing mechanism is movably connected to the chip carrying table; and the button mechanism is connected to the chip carrying table and has a first position state and a second position state, and when the button mechanism is in the first position state, the pressing mechanism is locked, so that the pressing mechanism presses the biochip in the at least one mounting position on the chip carrying table in a buckling manner, and when the button mechanism is in the second position state, the pressing mechanism presses the biochip in the at least one mounting position on the chip carrying table in a buckling manner. And when the button mechanism is in the second position state, the pressing mechanism is released, so that the pressing mechanism is separated from the biochip. According to the chip platform, the detection accuracy is improved, and the liquid leakage risk is reduced.

Description

Technical Field

[0001] The present application relates to optical detection technology, and in particular to a chip platform used in optical detection equipment. Background Art

[0002] An optical detection system includes a chip platform for carrying a biochip, which can be used to drive the biochip to move synchronously during optical scanning.

[0003] On the one hand, when the biochip is fixed to the chip platform, the spring force on the chip platform will cause the edge of the chip to bend and deform to a certain extent, resulting in warping of the chip edge. In severe cases, it can exceed the adjustment range of the optical detection system. This can easily cause the edge of the biochip to be out of focus when the optical detection system images the biochip, ultimately affecting the detection quality of the biochip edge.

[0004] On the other hand, biochips have liquid inlets and outlets on both sides. Because these inlets and outlets require springs to provide sealing force, the strength of this force significantly impacts the sealing effect. If the chip warps, this force can partially offset the sealing effect, weakening the seal and creating the risk of leakage. Utility Model Content

[0005] The present application provides a chip platform, comprising: a chip carrier, formed with at least one mounting position; a clamping mechanism, movably connected to the chip carrier; and a button mechanism, connected to the chip carrier, having a first position state and a second position state. When the button mechanism is in the first position state, the clamping mechanism is locked so that the clamping mechanism presses the biochip in the at least one mounting position onto the chip carrier. When the button mechanism is in the second position state, the clamping mechanism is released so that the clamping mechanism is separated from the biochip.

[0006] In at least one embodiment of the present application, the button mechanism includes: a fixed component forming a movable channel; and a movable component located in the movable channel, wherein the movable component can move in the movable channel to switch the button mechanism between the first position state and the second position state.

[0007] In at least one embodiment of the present application, the movable component includes a slider and an elastic member connected to the slider; the elastic member accumulates elastic potential energy when the button mechanism is in the second position state, and the elastic member drives the slider to move in the moving channel by releasing the elastic potential energy to reset the button mechanism from the second position state to the first position state.

[0008] In at least one embodiment of the present application, the fixed component is formed with a second opening, and the movable component further includes a column, one end of which is fixedly connected to the slider, and the other end is located in the second opening, and the slider can be controlled to move synchronously by moving the column.

[0009] In at least one embodiment of the present application, the fixing assembly includes an upper cover and a base, and the base is fixedly connected between the chip carrier and the upper cover; the upper cover and the base are buckled to form the movable channel together, and the second opening is opened in the upper cover.

[0010] In at least one embodiment of the present application, when the button mechanism is in the first position, the slider partially protrudes from the moving channel, and when the button mechanism is in the second position, the slider is completely accommodated in the moving channel.

[0011] In at least one embodiment of the present application, the clamping mechanism is formed with a first inclined surface, and the slider is formed with a second inclined surface; when the button mechanism is in the first position, the second inclined surface abuts against the first inclined surface to lock the clamping mechanism.

[0012] In at least one embodiment of the present application, the pressing mechanism is rotatably connected to the chip carrier, and the pressing mechanism rotates around an axis to press or release the biochip.

[0013] In at least one embodiment of the present application, the pressing mechanism includes a pressing frame. When the button mechanism is in the first position, the projection of the pressing frame on the chip carrier is located at an edge region of one of the mounting positions.

[0014] In at least one embodiment of the present application, the pressing mechanism and the button mechanism are connected to the same surface of the chip carrier.

[0015] The above-mentioned chip platform can control the clamping mechanism to clamp or loosen the biochip on the chip carrier by switching between the first position state and the second position state through the button mechanism. Therefore, it can effectively prevent the biochip from warping, avoid the edge of the biochip from being out of focus during imaging, and avoid leakage, which is beneficial to improving detection accuracy and reducing the risk of leakage. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a three-dimensional structural diagram of the chip platform according to an embodiment of the present application when pressing a biochip.

[0017] Figure 2 This is a three-dimensional structural diagram of the chip platform according to an embodiment of the present application when the biochip is released.

[0018] Figure 3 for Figure 1Exploded view of the button mechanism.

[0019] Figure 4 for Figure 1 A three-dimensional structural diagram of the middle pressing frame and button mechanism in one position.

[0020] Figure 5 for Figure 1 A three-dimensional structural diagram of the middle pressing frame and button mechanism in another position.

[0021] Description of main component symbols

[0022] Chip platform: 1; chip carrier: 10; surface: 11; mounting position: 111; pressing mechanism: 20; pressing frame: 21; first opening: 211; first inclined surface: 212; button mechanism: 30; fixing component: 31; moving channel: 311; upper cover: 312; base: 313; second opening: 314; movable component: 32; slider: 321; elastic member: 322; column: 323; second inclined surface: 324; base: 40; fine-tuning component: 50; adjusting member: 51; biochip: 2; chip body: 201; frame: 202.

[0023] The following specific implementation methods will further illustrate the present application in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0024] The present application provides a chip platform for use in an optical detection system. Examples of such optical detection systems include gene sequencers and optical microscopes. During operation of the optical detection system, the chip platform is used to support a biochip loaded with a biological sample. In at least one embodiment, the chip platform can also synchronously drive the biochip to achieve optical scanning. By clamping the biochip, the chip platform of the present application facilitates improved optical detection accuracy and reduced leakage risk during the optical detection process.

[0025] See also Figure 1 The chip platform 1 of the embodiment of the present application includes a chip carrier 10, a clamping mechanism 20, and a button mechanism 30. The clamping mechanism 20 and the button mechanism 30 are connected to the chip carrier 10. The button mechanism 30 can switch between different positions to control the clamping mechanism 20 to press the biochip 2 downward onto the chip carrier 10, or to release the biochip 2 on the chip carrier 10 to facilitate access to the biochip 2.

[0026] The chip carrier 10 has a carrying surface 11. A mounting position 111 is formed on the carrying surface 11. In the present embodiment, two mounting positions 111 are formed on the carrying surface 11 and are arranged in parallel and at intervals. The two mounting positions 111 are of the same shape and size and are respectively used to accommodate biochips 2 of the same shape and structure. In the present embodiment, the mounting position 111 is rectangular and is used to accommodate rectangular biochips 2, and the two mounting positions 111 are arranged side by side and at intervals in the short side direction. In other embodiments of the present application, the carrying surface 11 may be formed with fewer or more mounting positions 111, the mounting positions 111 may be of other shapes, and the arrangement of the mounting positions 111 may be different.

[0027] The clamping mechanism 20 is movably connected to the support surface 11. In this embodiment, one end of the clamping mechanism 20 is rotatably connected to the support surface 11. If a biochip 2 is positioned in the mounting position 111, the clamping mechanism 20 rotates so that the other end gradually approaches the support surface 11 of the chip carrier 10, gradually pressing the biochip 2. The clamping mechanism 20 rotates so that the other end gradually moves away from the support surface 11 of the chip carrier 10, gradually releasing the biochip 2.

[0028] In this embodiment, the chip platform 1 includes two independently arranged clamping mechanisms 20 for respectively clamping or releasing the two biochips 2. The two clamping mechanisms 20 have substantially the same structure and function. In other embodiments of the present application, the chip platform 1 may include fewer or more clamping mechanisms 20, as long as the number of clamping mechanisms 20 is the same as the number of mounting positions 111.

[0029] In this embodiment, each pressing mechanism 20 includes a pressing frame 21. Because both the biochip 2 and the mounting position 111 for loading the biochip 2 have rectangular planar structures, the pressing frame 21 also has a corresponding rectangular first opening 211. The long side of the rectangular first opening 211 is parallel to the long side of the mounting position 111, and the short side of the rectangular first opening 211 is also parallel to the short side of the mounting position 111. Figure 1 The figure shows the state of the compression frame 21 pressing against the biochip 2. When pressing against the biochip 2, the compression frame 21 presses against the edge of the biochip 2, leaving the central rectangular area of ​​the biochip 2 (i.e., the sample area for placing the biological sample) exposed relative to the first opening 211 of the compression frame 21 for optical detection.

[0030] Figure 2 The figure shows the state when the pressing frame 21 releases the biochip 2. The pressing frame 21 is directed away from the chip carrier 10 (i.e., Figure 2 When the biochip 2 is rotated (direction downward and upward), the biochip 2 can be released, and the biochip 2 can be easily taken out in this state.

[0031] In this embodiment, the chip platform 1 includes two separately arranged button mechanisms 30 to respectively control the two clamping mechanisms 20. In other embodiments of the present application, the chip platform 1 may include fewer or more button mechanisms 30, as long as the number of button mechanisms 30 is the same as that of the clamping mechanisms 20 and they correspond one to one.

[0032] See also Figure 3 In this embodiment, each button mechanism 30 includes a fixed component 31 and a movable component 32. The fixed component 31 is formed with a moving channel 311. The movable component 32 moves in the moving channel 311 to switch the button mechanism 30 between a first position state and a second position state. When the button mechanism 30 is in the first position state, it can clamp the pressing mechanism 20, so that the pressing mechanism 20 keeps clamping the biochip 2 (see Figure 1 When the button mechanism 30 is in the second position, the pressing mechanism 20 is released (see Figure 2 ), causing the pressing mechanism 20 to spring up to release the biochip 2.

[0033] Please also refer to Figure 2 and Figure 3 The fixing assembly 31 includes a top cover 312 and a base 313. The base 313 is fixedly connected between the top cover 312 and the chip carrier 10. In this embodiment, the base 313 is fixedly connected to the support surface 11. The top cover 312 and the base 313 are both formed with grooves on the opposite sides, so that when the top cover 312 and the base 313 are engaged, the above-mentioned movement channel 311 is formed.

[0034] Please refer to Figure 3 The movable component 32 includes a slider 321, an elastic member 322 and a column 323. The elastic member 322 and the column 323 are respectively fixedly connected to the slider 321. The slider 321 is at least partially located in the movable channel 311. The elastic member 322 is connected to the side of the slider 321 away from the clamping mechanism 20. In this embodiment, the elastic member 322 is a spring, which is at least partially located in the movable channel 311. The upper cover 312 is provided with a second opening 314 that passes through the upper cover 312. One end of the column 323 is connected to the slider 321 in the movable channel 311, and the other end protrudes out of the upper cover 312 from the second opening 314. That is, the slider 321 is located between the column 323 and the base 313. The column 323 is at least partially located in the movable channel 311.

[0035] In this embodiment, the opening area of ​​the second opening 314 is larger than the cross-sectional area of ​​the pillar 323, so that the pillar 323 can move in the second opening 314. By moving the pillar 323 in the second opening 314, the slider 321 can be moved synchronously in the moving channel 311. In this embodiment, the pillar 323 can move along the linear direction X in the second opening 314, and the slider 321 can move along the linear direction X in the moving channel 311. The linear direction X is parallel to the bearing surface 11 (see Figure 1 and Figure 2 ), and parallel to the mounting position 111 (see Figure 1 and Figure 2 ) in the direction of the long side.

[0036] Figure 4 The structure of the button mechanism 30 in the first position is shown. When the button mechanism 30 is in the first position, if the column 323 is moved in the direction away from the pressing frame 21 along the straight line direction X, the slider 321 can move in the direction away from the pressing frame 21 in the moving channel 311 (see FIG. Figure 3 ) moves in the interior, during which the elastic member 322 stores elastic potential energy.

[0037] See also Figure 5 When the column 323 is pushed to the limit position in the direction away from the pressing frame 21, the button mechanism 30 is in the second position. When the column 323 is released in the second position, the elastic member 322 releases the elastic potential energy to drive the slider 321 toward the pressing frame 21 until the elastic potential energy is released. At this time, the button mechanism 30 can be switched to the second position again. Figure 4 The first position state is shown.

[0038] That is, by moving the column 323, the button mechanism 30 can be switched from the first position to the second position. When the button mechanism 30 is in the second position, the column 323 is released, and the button mechanism 30 automatically returns to the first position. This allows for convenient switching of the button mechanism 30's position. Therefore, when the compression frame 21 is holding the biochip, to remove the biochip, one can first move the column 323 to release the compression frame 21, then release the column 323 to reset the button mechanism 30. At this point, the button mechanism is in the first position, and the compression frame 21 springs up, allowing the biochip to be removed.

[0039] Please refer to Figure 4 The pressing frame 21 is formed with a first inclined surface 212 at one end thereof facing the button mechanism 30, and the slider 321 is formed with a second inclined surface 324 at one end thereof facing the pressing frame 21. When the button mechanism 30 is in the first position, the slider 321 moves from the moving channel 311 (see FIG. Figure 3 ) Extend.

[0040] When the button mechanism 30 is in the first position and the pressing frame 21 pops up, if you want to press the biochip, you can press the pressing frame 21 down. After pressing the pressing frame 21 down so that it contacts the slider 321, if you continue to press the pressing frame 21 down, the slider 321 will be squeezed and completely retracted into the movable channel 311, causing the button mechanism 30 to switch to the second position. Continuing to press the pressing frame 21 down, when the first inclined surface 212 of the pressing frame 21 is lower than the position of the second inclined surface 324 of the slider 321, the slider 321 is no longer subjected to the squeezing force and partially pops out of the movable channel 311, causing the button mechanism 30 to switch to the first position. At this time, the first inclined surface 212 and the second inclined surface 324 abut against each other, and the pressing frame 21 is locked by the slider 321, and remains pressed against the edge area of ​​the biochip 2.

[0041] Please refer to Figure 2 In this embodiment, each clamping mechanism 20 and its corresponding button mechanism 30 are respectively arranged at two opposite sides of the bearing surface 11, and the corresponding clamping mechanisms 20 and button mechanisms 30 are respectively arranged at two short sides of the installation position 111.

[0042] The chip platform 1 of the embodiment of the present application also includes a base 40 and a fine-tuning assembly 50. The chip carrier 10 is fixedly connected to the base 40 via the fine-tuning assembly 50. The fine-tuning assembly 50 includes three adjustment members 51. In this embodiment, the bearing surface 11 is rectangular, wherein two adjustment members 51 are respectively located at two adjacent corners of the chip carrier 10, and another adjustment member 51 is located at the center of the bearing surface 11. By twisting the three adjustment members 51, the distance between the chip carrier 10 and the base 40 can be adjusted, and thus the three adjustment members 51 are used to jointly achieve leveling of the bearing surface 11.

[0043] In this embodiment, the chip carrier 10 secures the biochip 2 to the mounting position 111 by suction, creating negative pressure. The biochip 2 also includes a chip body 201 and a frame 202 formed around the chip body 201. The frame 202 is made of plastic and serves to protect the chip body 201 and assist in positioning the chip. When the compression frame 21 presses against the biochip 2, it directly contacts the frame 202 without contacting the chip body 201.

[0044] The chip platform 1 of the embodiment of the present application can control the clamping mechanism 20 to clamp or release the biochip 2 on the chip carrier 10 by switching the button mechanism 30 between the first position and the second position. The clamping mechanism 20 clamps the edge region of the biochip 2, leaving the center region of the biochip 2 exposed relative to the clamping mechanism 20. Therefore, while ensuring normal optical scanning of the biochip 2, it can also effectively prevent the edge of the biochip 2 from warping, preventing the edge of the biochip 2 from being out of focus during imaging and preventing leakage. In other words, the chip platform 1 of the embodiment of the present application is conducive to improving the accuracy of optical detection and reducing the risk of leakage.

[0045] Those skilled in the art should recognize that the above embodiments are only used to illustrate the present application and are not used to limit the present application. As long as they are within the spirit of the present application, appropriate changes and modifications to the above embodiments are within the scope of protection claimed in the present application.

Claims

1. A chip platform, characterized in that: include: The chip carrier is formed with at least one mounting position; A pressing mechanism, movably connected to the chip carrier; as well as A button mechanism is connected to the chip carrier and has a first position state and a second position state. When the button mechanism is in the first position state, the clamping mechanism is locked so that the clamping mechanism presses the biochip in the at least one mounting position onto the chip carrier. When the button mechanism is in the second position state, the clamping mechanism is released so that the clamping mechanism is separated from the biochip.

2. The chip platform according to claim 1, wherein: The button mechanism comprises: a fixed assembly forming a moving channel; and A movable component is located in the moving channel, and the movable component can move in the moving channel to switch the button mechanism between the first position state and the second position state.

3. The chip platform according to claim 2, wherein: The movable assembly includes a slider and an elastic member connected to the slider; The elastic member accumulates elastic potential energy when the button mechanism is in the second position state, and the elastic member drives the slider to move in the moving channel by releasing the elastic potential energy, so as to reset the button mechanism from the second position state to the first position state.

4. The chip platform according to claim 3, wherein: The fixed component is formed with a second opening, and the movable component further includes a column, one end of which is fixedly connected to the slider, and the other end is located in the second opening. The slider can be controlled to move synchronously by toggling the column.

5. The chip platform according to claim 4, wherein: The fixing assembly includes an upper cover and a base, and the base is fixedly connected between the chip carrier and the upper cover; The upper cover and the base are buckled together to form the moving channel, and the second opening is opened on the upper cover.

6. The chip platform according to claim 3, wherein: When the button mechanism is in the first position, the slider partially protrudes out of the moving channel. When the button mechanism is in the second position, the slider is completely accommodated in the moving channel.

7. The chip platform according to claim 6, wherein: The pressing mechanism is formed with a first inclined surface, and the sliding block is formed with a second inclined surface; When the button mechanism is in the first position, the second inclined surface abuts against the first inclined surface to lock the pressing mechanism.

8. The chip platform according to any one of claims 1 to 7, wherein: The pressing mechanism is rotatably connected to the chip carrier, and the pressing mechanism rotates around an axis to press or release the biochip.

9. The chip platform according to any one of claims 1 to 7, wherein: The pressing mechanism includes a pressing frame. When the button mechanism is in the first position, a projection of the pressing frame on the chip carrier is located at an edge region of one of the mounting positions.

10. The chip platform according to any one of claims 1 to 7, wherein: The pressing mechanism and the button mechanism are connected to the same surface of the chip carrier.

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