Multi-channel multi-joint detection POCT full-automatic chemiluminescence equipment

Abstract

The multi-channel multi-joint inspection POCT full-automatic chemiluminescence equipment comprises a mounting frame, a plurality of POCT light sources and a plurality of POCT light sources, the reaction bin assembly is loaded with a multi-joint detection reagent strip, the multi-joint detection reagent strip is used for detecting at least two markers, and the multi-joint detection reagent strip comprises a liquid sealing area, a public liquid area and a special liquid area of the liquid sealing area; the multi-channel multi-joint detection parallel pretreatment device comprises at least two rows of magnetic rods, each row of magnetic rods comprises at least two magnetic rods, and the at least two rows of magnetic rods are used for transferring magnetic particles in adjacent hole sites of a multi-joint detection reagent strip in a liquid sealing area; the film breaking assembly is used for breaking the sealing film of the public liquid area; the reaction bin assembly is used for moving the multi-joint detection reagent strip to the PMT assembly, and the PMT assembly is used for carrying out luminescence value detection on the detection position of the multi-joint detection reagent strip. According to the utility model, multi-channel parallel processing and multi-joint detection are realized at the same time, the analysis efficiency of equipment is ensured, and efficient detection of multiple detection items can be realized while the size of the equipment is controlled.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to a multi-channel multi-detection POCT fully automatic chemiluminescence device. Background Art

[0002] Chemiluminescent immunoassay (CLIA), a rapidly developing non-radioactive immunoassay technology, has become a key area of ​​immunology. It utilizes chemiluminescent signals to directly measure immune responses. Chemiluminescent equipment utilizing CLIA offers advantages such as high sensitivity, good repeatability, high accuracy, good specificity, and a wide linear range.

[0003] POCT (Point-Of-Care Testing) is a testing method that conducts clinical testing immediately at the sampling site, eliminating the complex processing procedures of specimens in laboratory testing and quickly obtaining test results. It has the characteristics of instrument programming, simple operation and fast reporting of results.

[0004] At present, by applying chemiluminescence immunoassay technology to POCT products, a multi-channel, multi-detection POCT fully automatic chemiluminescence device has been manufactured. This device has the advantages of instant detection and rapid acquisition of diagnostic results, and has been rapidly and widely promoted in the in vitro diagnostic industry.

[0005] A multi-channel, multi-test, fully automated chemiluminescence device for point-of-care testing typically includes a reaction chamber module and a multi-channel parallel pre-processing module. The reaction chamber module holds reagent strips containing various reagents and moves the strips to the multi-channel parallel pre-processing module for processing, such as breaking the film seals on the reagent wells and transferring magnetic particles. The length of the reagent strip is affected by the number of test items. As the number of test items increases, the number of reagents in the strip also needs to increase, which in turn increases the strip's length.

[0006] When the device is used for detection and analysis of multiple projects, the distance that the reaction chamber module needs to move with the reagent strip in the device will increase before the reagent strip can be moved to the multi-channel parallel pre-processing module for corresponding processing. If a longer distance is required to enable the multi-channel parallel pre-processing device to break the sealing film on the reagent strip, the size of the device will increase, which is not conducive to the miniaturization of the device and will also prolong the time for detection and obtaining diagnostic results.

[0007] In addition, the current multi-channel parallel pre-processing module can only transfer magnetic particles in one well on the reagent strip at a time. If magnetic particles in multiple wells need to be transferred, multiple operations are required, which increases the risk of cross-interference and prolongs the transfer time of the magnetic particles. Moreover, since it takes a long time to transfer magnetic particles multiple times, the analysis efficiency of the equipment is affected. Utility Model Content

[0008] An embodiment of the present utility model provides a multi-channel, multi-detection POCT fully automatic chemiluminescence device, which aims to solve the technical problems of how to control the device volume and ensure the device detection speed when the reagent strip grows to adapt to multiple detection needs, and the existing multi-channel parallel pre-processing module requires multiple operations when transferring magnetic particles in multiple wells, resulting in an increased risk of cross-interference, prolonged transfer time of magnetic particles and affected analysis efficiency of the device.

[0009] The embodiment of the present invention is implemented as follows: a multi-channel multi-detection POCT fully automatic chemiluminescence device, comprising:

[0010] Install the frame;

[0011] a reaction chamber assembly disposed on the mounting frame and configured to load a multiple-test reagent strip, the reaction chamber assembly being reciprocally movable along the length of the mounting frame; the multiple-test reagent strip being configured to detect at least two markers; the multiple-test reagent strip comprising a liquid sealing area, the liquid sealing area comprising a common liquid area and a dedicated liquid area distributed along the length of the multiple-test reagent strip;

[0012] A multi-channel multi-test parallel pre-processing device is provided on the mounting frame, the multi-channel multi-test parallel pre-processing device comprising at least two rows of magnetic bars arranged side by side along the movement direction of the reaction chamber assembly, each row of the magnetic bars having at least two magnetic bars, the at least two rows of the magnetic bars being used to transfer magnetic particles in adjacent wells of the multi-test reagent strip into the liquid sealing area;

[0013] a membrane breaking assembly provided on the mounting frame and located at the rear end of the multi-channel multi-inspection parallel pre-processing device, the membrane breaking assembly being used to break the sealing film of the common liquid area; and

[0014] The PMT component is provided on the mounting frame and located at the rear end of the membrane rupturing component. The reaction chamber component is used to move the multi-detection reagent strip to the PMT component. The PMT component is used to detect the luminescence value of the detection position of the multi-detection reagent strip.

[0015] Furthermore, the multi-channel multi-joint detection parallel pre-processing device includes:

[0016] a gantry provided on the bottom plate of the mounting frame, wherein a first driving element is provided on the top of the gantry;

[0017] a sample extraction mechanism disposed on the gantry, the sample extraction mechanism being in driving connection with the first driving element and capable of rising and falling under the drive of the first driving element to aspirate and discharge the sample on the multiple test strip; and

[0018] A sample pre-processing mechanism is provided on the gantry, the sample pre-processing mechanism is in transmission connection with the first driving element and can be raised and lowered under the drive of the first driving element, and at least two rows of magnetic bars are provided on the sample pre-processing mechanism.

[0019] Furthermore, the sample pre-processing mechanism includes:

[0020] A first mounting frame provided on the gantry and in transmission connection with the first driving element, wherein the first driving element can drive the first mounting frame to rise and fall;

[0021] a second driving element disposed on the first mounting bracket; and

[0022] A pre-processing component is arranged on the first mounting frame and is transmission-connected to the second driving element, at least two rows of magnetic rods are arranged on the pre-processing component and are transmission-connected to the second driving element, and the second driving element can drive at least two rows of magnetic rods to rise and fall to transfer magnetic particles.

[0023] Furthermore, the pre-processing component includes:

[0024] A magnetic bar device is provided on the first mounting frame, wherein a plurality of movable through holes are formed in the magnetic bar device, and a plurality of first loading heads for loading disposable magnetic separation sleeves are provided at the bottom of the magnetic bar device, wherein the plurality of first loading heads are in one-to-one communication with the plurality of movable through holes;

[0025] a first push plate disposed above the magnetic bar device, the first push plate being in driving connection with the second driving element; and

[0026] There are multiple connecting rods arranged on the first push plate, and at least two rows of magnetic bars are arranged one by one on the free ends of the multiple connecting rods. The second driving element can drive the first push plate to drive the magnetic bars to rise and fall in the corresponding movable through holes so as to be separated from or pass through the first loading head.

[0027] Furthermore, the magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly distributed along the width direction of the first push plate;

[0028] There are multiple magnetic bars in each row, and the multiple magnetic bars in each row are evenly distributed along the length direction of the first push plate.

[0029] Furthermore, the sample extraction mechanism includes:

[0030] A second mounting frame provided on the gantry and in transmission connection with the first driving element, wherein the first driving element can drive the second mounting frame to rise and fall;

[0031] a third driving element disposed on the second mounting bracket; and

[0032] An extraction component is arranged on the second mounting frame and is transmission-connected to the third driving element. The third driving element can drive the extraction component to rise and fall to aspirate and discharge samples.

[0033] Furthermore, the extraction component includes:

[0034] An injection device is provided on the second mounting frame, wherein a plurality of injection cavities are formed in the injection device, and a plurality of second loading heads for loading tip heads are provided at the bottom of the injection device, wherein the plurality of second loading heads are in one-to-one communication with the plurality of injection cavities;

[0035] a second push plate disposed above the injection device, the second push plate being in transmission connection with the third driving element; and

[0036] A plurality of piston rods are provided on the second push plate, and the piston rods are movably and sealedly connected to the syringe cavity. The third driving element can drive the second push plate to drive the piston rods to move up and down in the syringe cavity to perform a suction and exhalation action.

[0037] Furthermore, the sample extraction mechanism further includes:

[0038] A push rod is lifted and lowered through the injection device, wherein the top end of the push rod is spaced apart from the second push plate;

[0039] an elastic element sleeved on the push rod in the injection device, wherein the elastic element is simultaneously extended or compressed when the push rod is raised or lowered relative to the injection device; and

[0040] A separation plate is provided at the bottom of the injection device, the second loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the second loading head.

[0041] Furthermore, the plurality of syringe cavities are evenly spaced along the length direction of the injection device, the plurality of second loading heads are evenly spaced along the length direction of the injection device, and the plurality of piston rods are evenly spaced along the length direction of the second push plate.

[0042] Furthermore, the sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism, and the first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

[0043] Furthermore, a movable space is provided on the gantry, a transmission shaft of the first driving element passes through the movable space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the movable space when the transmission shaft moves;

[0044] A first connecting portion is provided on a side of the first mounting frame facing the gantry, and a second connecting portion is provided on a side of the second mounting frame facing the gantry. Both the first connecting portion and the second connecting portion are connected to the transmission plate.

[0045] Furthermore, a first slide is provided on a side of the first mounting frame facing the gantry, a first slide rail is provided on a side of the gantry facing the first mounting frame, the first slide rail extends along the height direction of the gantry, and the first slide is slidably connected to the first slide rail;

[0046] A second slide is provided on the side of the second mounting frame facing the gantry frame, and a second slide rail is provided on the side of the gantry frame facing the second mounting frame. The second slide rail extends along the height direction of the gantry frame, and the second slide is slidably connected to the second slide rail.

[0047] Furthermore, a first sensing member is provided on one side of the top of the first mounting frame, and a first detector is provided on one side of the top of the gantry frame, and the first sensing member can generate or disconnect induction with the first detector as the first mounting frame rises and falls;

[0048] A second induction member is provided on one side of the top of the second mounting frame, and a second detector is provided on one side of the top of the gantry frame. The second induction member can generate or disconnect induction with the second detector as the second mounting frame rises and falls.

[0049] Furthermore, the reaction chamber assembly includes:

[0050] A guide rail provided on the bottom plate of the mounting frame;

[0051] A reaction chamber body is provided on the guide rail, wherein a guide block is provided at the bottom of the reaction chamber body and is slidably connected to the guide rail. The reaction chamber body is provided with a plurality of evenly spaced receiving grooves for loading the multi-test reagent strips, and the receiving grooves extend along the length direction of the reaction chamber body;

[0052] a fourth driving element disposed on the bottom plate of the mounting frame and located at the rear end of the guide rail, wherein a first driving pulley is disposed on a transmission shaft of the fourth driving element;

[0053] a mounting base provided on the bottom plate of the mounting frame and located at the front end of the guide rail, wherein the mounting base is provided with a first driven pulley, and the first driving pulley is connected to the first driven pulley via a belt; and

[0054] A first synchronous belt pressure plate is provided on one side of the reaction chamber body, and the first synchronous belt pressure plate is connected to a belt.

[0055] Furthermore, the PMT assembly includes:

[0056] a mounting bracket provided on the bottom plate of the mounting frame;

[0057] a third mounting bracket provided on the mounting bracket;

[0058] a fourth mounting bracket provided at the bottom of the third mounting bracket;

[0059] A PMT module provided on the fourth mounting frame;

[0060] A fifth driving element is provided on the top of the third mounting frame and is transmission-connected to the fourth mounting frame, wherein the fifth driving element can drive the fourth mounting frame to move up and down to drive the PMT module to move up and down;

[0061] a sixth driving element and a second driven pulley respectively provided on both sides of the top of the mounting bracket, wherein a second driving pulley is provided on the transmission shaft of the sixth driving element, and the second driving pulley is connected to the second driven pulley via a belt; and

[0062] A second synchronous belt pressure plate is arranged on the third mounting frame, and the second synchronous belt pressure plate is connected to the belt.

[0063] Furthermore, the membrane rupturing component includes:

[0064] a seventh driving element disposed on the top of the mounting bracket;

[0065] a fifth mounting bracket provided on the mounting bracket and located below the seventh driving element, the fifth mounting bracket being in driving connection with the seventh driving element and capable of being raised and lowered by the seventh driving element; and

[0066] A plurality of membrane breaking heads are provided at the bottom of the fifth mounting frame, and the plurality of membrane breaking heads are evenly distributed along the length direction of the fifth mounting frame.

[0067] Furthermore, the multiple test reagent strip includes:

[0068] a reagent strip body, wherein the liquid sealing area is provided on the reagent strip body;

[0069] a handle provided at one end of the test strip body; and

[0070] A sample well, a tip, at least two disposable magnetic separation sleeves, the dedicated liquid area, and the common liquid area are arranged on the test strip body in sequence from the handle to the other end of the test strip body;

[0071] The dedicated liquid area includes at least two magnetic particle labeled ligands and at least two enzyme labeled ligands, and the public liquid area includes a cleaning liquid and a luminescent substrate liquid.

[0072] In an embodiment of the present invention, the multi-channel multi-joint detection parallel pre-processing device includes at least two rows of magnetic rods for transferring magnetic particles, and each row has at least two magnetic rods, that is, the multi-channel multi-joint detection parallel pre-processing device can simultaneously transfer the magnetic particles in at least two adjacent reagent wells on a single multi-joint detection reagent strip, and transfer the magnetic particles in adjacent reagent wells of at least two multi-joint detection reagent strips arranged in parallel, thereby realizing the analysis and detection of at least two markers, realizing multi-joint detection while realizing multi-channel parallel processing, reducing the risk of cross infection, shortening the time for transferring magnetic particles, and ensuring the analysis efficiency of the equipment.

[0073] Moreover, based on the structure of the equipment and combined with the special design of the multi-test reagent strip, the operation of breaking the sealing film of the multi-test reagent strip does not need to be completely performed by the multi-channel multi-test parallel pre-treatment device, but the sealing film of the common liquid area can be broken by the membrane breaking component at the rear end. The reaction chamber component does not need to move the multi-test reagent strip for a long distance to achieve targeted membrane breaking, thereby reducing the repeated and long-distance movement of the reaction chamber component and the repeated membrane breaking work of the multi-channel multi-test parallel pre-treatment device. It can achieve efficient detection of multiple detection items while controlling the volume of the multi-channel multi-test POCT fully automatic chemiluminescence equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0074] Figure 1 This is a three-dimensional schematic diagram of a multi-channel multi-detection POCT fully automatic chemiluminescence device according to an embodiment of the present invention;

[0075] Figure 2 This is another perspective schematic diagram of a multi-channel multi-detection POCT fully automatic chemiluminescence device that is part of an embodiment of the present invention;

[0076] Figure 3 This is another perspective schematic diagram of a multi-channel multi-detection POCT fully automatic chemiluminescence device that is part of an embodiment of the present invention;

[0077] Figure 4 This is a schematic structural diagram of a multiple-test reagent strip according to an embodiment of the present invention;

[0078] Figure 5 1 is a cross-sectional schematic diagram of a multiple test reagent strip according to an embodiment of the present invention;

[0079] Figure 6 This is a three-dimensional schematic diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0080] Figure 7 This is another three-dimensional schematic diagram of the multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0081] Figure 8 This is a three-dimensional disassembled schematic diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present utility model;

[0082] Figure 9 This is a schematic structural diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0083] Figure 10 It is a three-dimensional schematic diagram of the gantry frame of the embodiment of the utility model;

[0084] Figure 11 This is another perspective schematic diagram of the gantry frame according to an embodiment of the present utility model;

[0085] Figure 12 It is a three-dimensional schematic diagram of a sample pre-processing mechanism according to an embodiment of the present utility model;

[0086] Figure 13 It is a three-dimensional schematic diagram of the sample extraction mechanism of an embodiment of the utility model;

[0087] Figure 14 This is a three-dimensional schematic diagram of the reaction chamber body of an embodiment of the present utility model;

[0088] Figure 15 This is a three-dimensional schematic diagram of the membrane breaking component and the PMT component of an embodiment of the present utility model;

[0089] Figure 16 It is a three-dimensional schematic diagram of the PMT assembly of an embodiment of the present utility model.

[0090] Description of main component symbols:

[0091] Multi-channel multi-detection POCT fully automatic chemiluminescence equipment-100;

[0092] Mounting frame - 10;

[0093] Multiple test reagent strip-20; reagent strip body-21; liquid sealing area-211; dedicated liquid area-2111; common liquid area-2112; handle-22; sample well-23; tip-24; disposable magnetic separation sleeve-25;

[0094] Reaction chamber assembly 30; guide rail 31; reaction chamber body 32; accommodating groove 33; fourth driving element 34; mounting seat 35; first driven pulley 36;

[0095] Multi-channel, multi-joint-test, parallel pre-processing device-40; gantry-41; first drive element-411; movable space-412; transmission plate-413; first slide rail-414; second slide rail-415; sample extraction mechanism-42; second mounting frame-421; second slide-4211; third drive element-422; extraction assembly-423; injection device-4231; second loading head-4232; second push plate-4233; piston rod-4234; push rod-4235; elastic element-4236; separation plate-4237; sample pre-processing mechanism-43; first mounting frame-431; first slide-4311; second drive element-432; pre-processing assembly-433; magnetic rod-4331; magnetic rod device-4332; first loading head-4333; first push plate-4334; connecting rod-4335;

[0096] Membrane rupture assembly-50; seventh drive element-51; fifth mounting frame-52; membrane rupture head-53;

[0097] PMT assembly-60; mounting bracket-61; third mounting bracket-62; fourth mounting bracket-63; PMT module-64; fifth drive element-65; sixth drive element-66; second driven pulley-67; second synchronous belt pressure plate-68. DETAILED DESCRIPTION

[0098] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. Examples of the embodiments are shown in the accompanying drawings, in which the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and are not to be construed as limiting the present invention. In addition, it should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0099] In the description of the present invention, it should be understood that the orientation or positional relationship indicated in the description of the direction and positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0100] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the described features. In the description of this utility model, "plurality" means two or more, unless otherwise specifically defined.

[0101] The disclosure below provides many different embodiments or examples for realizing different structures of the present invention. In order to simplify the disclosure of the present invention, the components and settings of specific examples are described below. Of course, they are merely examples and are not intended to limit the present invention. In addition, the present invention may repeat reference numbers and / or reference letters in different examples. Such repetition is for the purpose of simplicity and clarity and does not in itself indicate the relationship between the various embodiments and / or settings discussed. In addition, the present invention provides examples of various specific processes and materials, but a person of ordinary skill in the art will appreciate the application of other processes and / or the use of other materials.

[0102] See also Figures 1 to 7 and Figure 12 The multi-channel multi-detection POCT fully automatic chemiluminescence device 100 of the embodiment of the present invention includes:

[0103] Mounting frame 10;

[0104] A reaction chamber assembly 30 is provided on the mounting frame 10 and is used to load the multiple test reagent strip 20. The reaction chamber assembly 30 can reciprocate along the length of the mounting frame 10. The multiple test reagent strip 20 is used to detect at least two markers. The multiple test reagent strip 20 includes a liquid sealing area 211. The liquid sealing area 211 includes a common liquid area 2112 and a dedicated liquid area 2111 distributed along the length of the multiple test reagent strip 20.

[0105] A multi-channel, multi-test parallel pre-processing device 40 is provided on the mounting frame 10 and above the reaction chamber assembly 30. The multi-channel, multi-test parallel pre-processing device 40 includes at least two rows of magnetic bars 4331 arranged side by side along the movement direction of the reaction chamber assembly 30. Each row of magnetic bars 4331 has at least two magnetic bars. The at least two rows of magnetic bars 4331 are used to transfer magnetic particles in adjacent wells of the multi-test reagent strip 20 into the liquid sealing area 211.

[0106] A membrane rupturing assembly 50 is provided on the mounting frame 10 and is located at the rear end of the multi-channel multi-inspection parallel pre-processing device 40. The membrane rupturing assembly 50 is used to rupture the sealing film of the common liquid area 2112; and

[0107] The PMT assembly 60 is provided on the mounting frame 10 and is located at the rear end of the membrane rupturing assembly 50 and above the reaction chamber assembly 30. The reaction chamber assembly 30 is used to move the multi-detection reagent strip 20 to the PMT assembly 60. The PMT assembly 60 is used to detect the luminescence value of the detection position of the multi-detection reagent strip 20.

[0108] In the multi-channel multi-test POCT fully automatic chemiluminescence device 100 of the embodiment of the present utility model, the multi-channel multi-test parallel pre-processing device 40 includes at least two rows of magnetic rods 4331 for transferring magnetic particles, and there are at least two magnetic rods 4331 in each row, that is, the multi-channel multi-test parallel pre-processing device 40 can simultaneously transfer the magnetic particles in at least two adjacent reagent wells on a single multi-test reagent strip 20, and transfer the magnetic particles in adjacent reagent wells of at least two multi-test reagent strips 20 arranged in parallel, thereby realizing the analysis and detection of at least two markers, realizing multi-test while realizing multi-channel parallel processing, reducing the risk of cross infection, shortening the time for transferring magnetic particles, and ensuring the analysis efficiency of the equipment.

[0109] Moreover, based on the structure of the equipment and combined with the special design of the multi-test reagent strip 20, the operation of breaking the sealing film of the multi-test reagent strip 20 does not need to be completely performed by the multi-channel multi-test parallel pre-processing device 40, but can be performed by the membrane breaking component 50 at the rear end to break the sealing film of the common liquid area 2112. The reaction chamber component 30 does not need to move the multi-test reagent strip 20 for a long distance to achieve targeted membrane breaking, thereby reducing the repeated and long-distance movement of the reaction chamber component 20 and the repeated membrane breaking work of the multi-channel multi-test parallel pre-processing device 40. While controlling the volume of the multi-channel multi-test POCT fully automatic chemiluminescence device 100, efficient detection of multiple detection items can be achieved.

[0110] Specifically, the multi-channel multi-test POCT fully automatic chemiluminescence device 100 of the embodiment of the present invention is roughly rectangular in shape, and the mounting frame 10 is the basic structure of the multi-channel multi-test POCT fully automatic chemiluminescence device 100. The mounting frame 10 may include a base plate, multiple side plates and a top plate arranged on the base plate, etc. The mounting frame 10 surrounded by the above-mentioned base plate, multiple side plates and top plate is also roughly rectangular in shape.

[0111] The mounting frame 10 is used to carry and install the above-mentioned reaction chamber assembly 30, multi-channel multi-inspection parallel pre-processing device 40, membrane rupture assembly 50 and PMT assembly 60 and other components. The above-mentioned reaction chamber assembly 30, multi-channel multi-inspection parallel pre-processing device 40, membrane rupture assembly 50 and PMT assembly 60 and other components are arranged in the space of the mounting frame 10. The mounting frame 10 provides stable support for the above-mentioned components and protects the above-mentioned components from interference from external impurities, water vapor, etc.

[0112] A plurality of parallel accommodating grooves 33 may be formed on the reaction chamber assembly 30, and the accommodating grooves 33 extend along the length direction of the reaction chamber assembly 30. The multi-test reagent strips 20 are loaded in the accommodating grooves 33. The plurality of accommodating grooves 33 may accommodate a plurality of multi-test reagent strips 20, that is, the reaction chamber assembly 30 may drive the plurality of multi-test reagent strips 20 to move in the multi-channel multi-test POCT fully automatic chemiluminescence device 100, thereby enabling the multi-channel multi-test POCT fully automatic chemiluminescence device 100 to perform multi-channel detection and analysis on a plurality of test strips in sequence.

[0113] See also Figure 4 and Figure 5 Furthermore, the multiple test reagent strip 20 includes:

[0114] The reagent strip body 21, the liquid sealing area 211 is provided on the reagent strip body 21;

[0115] a handle 22 provided at one end of the test strip body 21; and

[0116] The sample well 23, the tip 24, at least two disposable magnetic separation sleeves 25, the dedicated liquid area 2111 and the common liquid area 2112 are arranged on the test strip body 21 in sequence from the handle 22 to the other end of the test strip body 21;

[0117] The dedicated liquid area 2111 includes at least two magnetic particle labeled ligands and at least two enzyme labeled ligands, and the public liquid area 2112 includes a cleaning solution and a luminescent substrate solution.

[0118] In the embodiment of the present invention, the multiple-test reagent strip 20 is a disposable consumable that can be directly discarded after use. The multiple-test reagent strip 20 is generally in the shape of an elongated strip, and a handle 22 may be provided at one end. The handle 22 may be provided with anti-slip grooves to increase the friction between the multiple-test reagent strip 20 and the operator's fingers, making it easier for the operator to grip it firmly.

[0119] From one end of the handle 22 toward the other end of the multi-test reagent strip 20, there are sequentially provided a sample well 23, a tip well, at least two disposable magnetic separation sleeve wells, at least two magnetically labeled ligand wells, at least two enzyme-labeled ligand wells, multiple wash solution wells, and multiple substrate reading wells (i.e., the aforementioned detection positions). The magnetically labeled ligand wells and the enzyme-labeled ligand wells form a dedicated liquid area 2111, the wash solution wells and the substrate reading wells form a shared liquid area 2112, and the dedicated liquid area 2111 and the shared liquid area 2112 form a liquid sealing area 211.

[0120] The sample well 23 is used to add a blood sample. The tip well is provided with a tip 24. The disposable magnetic separation sleeve well is provided with a disposable magnetic separation sleeve 25. The magnetically labeled ligand well contains a magnetically labeled ligand, and the enzyme-labeled ligand well contains an enzyme-labeled ligand. Ligands include, but are not limited to, haptens, antigens, monoclonal antibodies, polyclonal antibodies, and nucleic acid ligands. The cleaning solution well contains a cleaning solution, and the substrate reading well contains a substrate reading. The number of rows of magnetic rods 4331 is equal to the number of disposable magnetic separation sleeve wells, magnetically labeled ligand wells, enzyme-labeled ligand wells, and substrate reading wells.

[0121] In addition, after the corresponding reagents are encapsulated in the corresponding holes of the multiple test strip 20, the surface of the multiple test strip 20 can be heat-sealed with a film to prevent the reagents in each hole from leaking or being contaminated, and also facilitate the storage and transportation of the multiple test strip 20.

[0122] The tip 24 is a hollow structure with a sharp end and a perforation, allowing it to be used to transfer samples or reagents and to remove the film seals at each well. The disposable magnetic separation sleeve 25 is used for adsorption, mixing, cleaning, and transferring magnetic particles. The cleaning solution well is used to clean the magnetic particles. The substrate reading well is used to perform the chemiluminescence reaction and read the luminescence value.

[0123] In an embodiment of the present invention, the dedicated liquid area 2111 can be understood as components directly related to the detection items (such as magnetic bead-labeled ligands, enzyme-labeled ligands and pretreatment liquids, etc.), where the ligands include haptens, antigens, antibodies and nucleic acid probes, etc., and the common liquid area 2112 can be understood as components that can be shared between detection items (such as cleaning liquid and luminescent liquid, etc.).

[0124] In the common liquid area 2112, even if the membrane breaking component 50 is contaminated with liquid in one hole during the previous membrane breaking process and then contaminates the liquid into other holes, it will not have a significant impact on the detection results. Therefore, the embodiment of the present invention designs the membrane breaking component 50 to specifically break the sealing film of the common liquid area 2112, reduce the membrane breaking work of the multi-channel multi-inspection parallel pre-treatment device 40, shorten the moving distance of the reaction chamber component 30, control the equipment volume and improve the multi-project analysis efficiency of the equipment.

[0125] Since the reaction chamber assembly 30 is arranged on the bottom plate of the mounting frame 10, the PMT assembly 60 can be arranged above the bottom plate through a bracket or other structure, that is, the PMT assembly 60 is located relatively above the reaction chamber assembly 30. To ensure that the PMT assembly 60 can detect the luminescence values ​​of all the multi-test reagent strips 20 in the reaction chamber assembly 30, the PMT assembly 60 can move up, down, left and right in the mounting frame 10, that is, it can move in the vertical direction and the horizontal direction (the width direction of the mounting frame 10), thereby approaching or moving away from the multi-test reagent strip 20 and moving back and forth between multiple multi-test reagent strips 20.

[0126] Similarly, the multi-channel multi-test parallel pre-processing device 40 can also be arranged above the bottom plate through a bracket or other structure, that is, the multi-channel multi-test parallel pre-processing device 40 is located relatively above the reaction chamber assembly 30. In order to ensure that the multi-channel multi-test parallel pre-processing device 40 can pre-process all the multi-test reagent strips 20 in the reaction chamber assembly 30, the multi-channel multi-test parallel pre-processing device 40 can also move up and down in the installation frame 10, that is, it can move in the vertical direction, thereby approaching and moving away from the multi-test reagent strip 20 to transfer samples or reagents, break the sealing film on the hole position of the multi-test reagent strip 20, and adsorb, mix, wash and transfer magnetic particles, etc.

[0127] In an embodiment of the present invention, the multi-channel multi-test parallel pre-processing device 40 may include a two-part structure, one part of the structure is used to combine with the tip head 24 to transfer samples or reagents and break the sealing film of each hole, and the other part of the structure is used to combine with the disposable magnetic separation sleeve 25 to adsorb, mix, clean and transfer magnetic particles.

[0128] See also Figures 6 to 13 Furthermore, the multi-channel multi-joint inspection parallel pre-processing device 40 includes:

[0129] A gantry 41 is provided on the bottom plate of the mounting frame 10 , and a first driving element 411 is provided on the top of the gantry 41 ;

[0130] A sample extraction mechanism 42 is provided on the gantry 41 and is in driving connection with the first driving element 411. The sample extraction mechanism 42 can be raised and lowered by the first driving element 411 to aspirate and discharge the sample on the multiple test strip 20.

[0131] A sample pre-processing mechanism 43 is provided on the gantry 41 . The sample pre-processing mechanism 43 is in transmission connection with the first driving element 411 and can be raised and lowered under the drive of the first driving element 411 . At least two rows of magnetic rods 4331 are provided on the sample pre-processing mechanism 43 to transfer the magnetic particles on the multi-test reagent strip 20 .

[0132] Specifically, the gantry 41 can be made of metal materials, such as stainless steel, iron, aluminum, and various alloys, which have high strength and can extend the service life of the multi-channel pre-processing device 40. The gantry 41 spans the width of the mounting frame 10, allowing the sample extraction mechanism 42 and the sample pre-processing mechanism 43 to span above the reaction chamber assembly 30 to achieve multi-channel parallel pre-processing.

[0133] In an embodiment of the present utility model, the first driving element 411 can be a screw motor. The screw motor has high movement precision and is more accurate and stable in position adjustment. The first driving element 411 provided at the top of the gantry 41 drives the sample extraction mechanism 42 and the sample pre-processing mechanism 43 to rise and fall on the gantry 41, so that the sample extraction mechanism 42 and the sample pre-processing mechanism 43 are close to or away from the multi-test reagent strip 20, so that the sample extraction mechanism 42 cooperates with the tip head 24 on the multi-test reagent strip 20 to achieve functions such as membrane breaking, sample transfer or reagent transfer, and the sample pre-processing mechanism 43 cooperates with the disposable magnetic separation sleeve 25 on the multi-test reagent strip 20 to achieve adsorption, mixing, cleaning and transfer of magnetic particles.

[0134] In addition, the sample pre-processing mechanism 43 and the sample extraction mechanism 42 are located on opposite sides of the gantry 41 , for example, the sample pre-processing mechanism 43 is located on one side of the gantry 41 close to the PMT assembly 60 , and the sample extraction mechanism 42 is located on the other side of the gantry 41 .

[0135] In this way, it is possible to avoid arranging the sample pretreatment mechanism 43 and the sample extraction mechanism 42 on the same side of the gantry 41, which would cause the space on one side of the gantry 41 to be crowded and the load to be heavy, resulting in inconvenient operation and unstable structure of the gantry 41. In addition, the sample extraction mechanism 42 and the sample pretreatment mechanism 43 can be made to correspond to reagent holes with different functions on the multi-test reagent strip 20 respectively. For example, the front section of the multi-test reagent strip 20 requires more participation of the sample extraction mechanism 42, while the second half requires more participation of the sample pretreatment mechanism 43. This can further improve the pre-processing speed of the multi-channel multi-test parallel pre-processing device 40 on the multi-test reagent strip 20.

[0136] See also Figures 6 to 12 Furthermore, the sample pre-processing mechanism 43 includes:

[0137] A first mounting frame 431 is provided on the gantry 41 and is in transmission connection with the first driving element 411. The first driving element 411 can drive the first mounting frame 431 to move up and down;

[0138] a second driving element 432 disposed on the first mounting bracket 431; and

[0139] The pre-processing assembly 433 is mounted on the first mounting frame 431 and is in transmission connection with the second driving element 432 . The second driving element 432 can drive the pre-processing assembly 433 to move in a vertical direction to transfer the magnetic particles.

[0140] Specifically, the first drive element 411 can drive the first mounting frame 431 to rise and fall, thereby driving the sample pre-processing mechanism 43 to rise and fall, thereby performing corresponding treatments such as transferring magnetic particles on the multi-test reagent strip 20. The first mounting frame 431 can be roughly L-shaped, comprising two parts, such as a horizontal extension plate and a vertical extension plate. The second drive element 432 can be mounted on the horizontal extension plate to ensure a stable installation, thereby providing stable power for the raising and lowering of the pre-processing assembly 433.

[0141] The pre-processing component 433 is arranged on the vertical extension plate, and the second driving element 432 can be a screw motor. The screw motor has high movement accuracy and is more accurate and stable in position adjustment. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the pre-processing component 433. The transmission connection between the two can be a threaded connection, which can ensure the stability of the connection between the two. At the same time, the second driving element 432 can make the pre-processing component 433 move smoothly and accurately in the vertical direction through threaded drive, thereby smoothly and accurately adsorbing the magnetic particles and then transferring the magnetic particles.

[0142] Furthermore, in order to ensure that the pre-processing component 433 is smoothly raised and lowered on the first mounting frame 431, a slide rail extending in the vertical direction can be set on the first mounting frame 431, and a slider adapted to the slide rail can be set on the first push plate 4334. The stable movement of the pre-processing component 433 on the first mounting frame 431 is achieved through the cooperation of the slide rail and the slider.

[0143] In addition, a first detector (e.g., a photoelectric switch) can be disposed on one side of the top of the gantry 41, and a first sensing element (e.g., a baffle) can be disposed on one side of the top of the first mounting bracket 431. The first sensing element can be inductively coupled to or decoupled from the first detector as the first mounting bracket 431 is raised or lowered. When the first mounting bracket 431 drives the first sensing element to the first detector, decoupling the sensing element, indicating that the sample pre-treatment mechanism 43 has reached the desired height, the power supply to the first drive element 411 can be disconnected, preventing overload and damage to the first drive element 411 and conserving power.

[0144] Furthermore, a first slide 4311 may be provided on the side of the first mounting frame 431 facing the gantry 41 , and a first slide rail 414 extending along the height direction of the gantry 41 may be provided on the side of the gantry 41 facing the first mounting frame 431 , and the first slide 4311 is slidably connected to the first slide rail 414 .

[0145] The first slide 4311 and the first slide rail 414 are provided in two sets, which are respectively arranged on the left and right sides of the gantry 41 and the first mounting frame 431. Through the cooperation of the two sets of the first slide 4311 and the first slide rail 414, the first driving element 411 can drive the first mounting frame 431 to rise and fall smoothly on the gantry 41, thereby ensuring that the sample extraction mechanism 42 can rise and fall smoothly and accurately.

[0146] In an embodiment of the present utility model, the sample extraction mechanism 42 is opposite to the sample pre-processing mechanism 43 on the gantry 41, and the sample extraction mechanism 42 is located in front of the sample pre-processing mechanism 43. The first driving element 411, the second driving element 432 and the third driving element 422 are arranged linearly on the top of the gantry 41, so that the top structure of the multi-channel multi-inspection parallel pre-processing device 40 is regularly distributed, and the three driving elements are basically concentrated in the middle position of the gantry 41 when exerting force, so that the gantry 41 is evenly stressed and not prone to shaking or displacement.

[0147] See also Figure 9 and Figure 12 , further, the pre-processing component 433 includes:

[0148] A magnetic rod device 4332 is provided on the first mounting frame 431. A plurality of movable through holes are formed in the magnetic rod device 4332. A first loading head 4333 for loading the disposable magnetic separation sleeve 25 is provided at the bottom of the magnetic rod device 4332. The first loading head 4333 is connected to the movable through holes.

[0149] a first push plate 4334 disposed above the magnetic bar device 4332 , the first push plate 4334 being in driving connection with the second driving element 432 ; and

[0150] Multiple connecting rods 4335 are provided on the first pushing plate 4334, and at least two rows of magnetic bars 4331 are provided on the free ends of the multiple connecting rods 4335 in a one-to-one correspondence. The second driving element 432 can drive the first pushing plate 4334 to drive the magnetic bars 4331 to rise and fall in the corresponding movable through holes so as to be separated from or pass through the first loading head 4333.

[0151] Specifically, the magnetic bar device 4332 is roughly in the shape of a cuboid and is distributed along the width direction of the first mounting frame 431 , so that the movable through holes therein can be distributed in the width direction of the pre-processing component 433 to correspond to the location of the multi-test reagent strip 20 .

[0152] When the disposable magnetic separation sleeve 25 needs to be loaded, the first drive element 411 drives the first mounting frame 431 down to the first loading head 4333, where it contacts the disposable magnetic separation sleeve 25 for loading. An interference fit is created between the first mounting frame 431 and the first loading head 4333, ensuring the stability of the disposable magnetic separation sleeve 25 when loaded, while also facilitating separation. The first loading head 4333 is connected to the movable through-hole, thereby connecting the movable through-hole to the disposable magnetic separation sleeve 25. The second drive element 432 drives the connecting rod 4335, driving the magnetic rod 4331 through the first loading head 4333 and extending into the disposable magnetic separation sleeve 25. The magnetic particles can then be attracted by the disposable magnetic separation sleeve 25.

[0153] When the disposable magnetic separation sleeve 25 needs to be separated, the second driving element 432 is controlled to drive the magnetic rod 4331 downward until it contacts the bottom end of the disposable magnetic separation sleeve 25, thereby removing the disposable magnetic separation sleeve 25 from the first loading head 4333. When the second driving element 432 drives the connecting rod 4335 to separate the magnetic rod 4331 from the first loading head 4333 and separate the disposable magnetic separation sleeve 25, the magnetic field generated by the magnetic rod 4331 disappears, and the magnetic particles are separated from the disposable magnetic separation sleeve 25 and transferred.

[0154] Based on the design of at least two rows of magnetic rods 4331 in the pre-treatment component 433, the pre-treatment component 433 can be loaded with at least two rows of disposable magnetic separation sleeves 25 at a time, and the magnetic particles in at least two reagent wells can be transferred at a time through at least two rows of disposable magnetic separation sleeves 25. This not only improves the transfer speed of the magnetic particles to ensure the analysis efficiency of the equipment, but also realizes the multi-detection function of the equipment.

[0155] In addition, based on the transfer of magnetic particles, the pre-treatment component 433 combined with the disposable magnetic separation sleeve 25 can also be used to transfer the magnetic particles to the reagent for reaction mixing, or to separate the magnetic particles in the reaction solution into the cleaning solution, or to transfer the magnetic particles to the substrate reading for reaction and complete luminescence detection.

[0156] The transmission shaft of the second driving element 432 extends downward through the top of the first mounting frame 431 and the first push plate 4334. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the first push plate 4334 can be fixed on the fixing piece. When the transmission shaft of the second driving element 432 moves, the first push plate 4334 can be driven to rise and fall through the fixing piece to realize the lifting and lowering of the magnetic rod 4331.

[0157] Alternatively, a screw hole can be directly set on the first push plate 4334, and a thread can be set on the transmission shaft of the second driving element 432. The transmission shaft is threadedly connected to the first push plate 4334 (screw hole). In this way, the stability of the connection between the two can be guaranteed, and the second driving element 432 can also drive the first push plate 4334 to rise and fall smoothly through threaded driving.

[0158] See also Figure 9 and Figure 12 Furthermore, the magnetic rods 4331 are arranged in multiple rows, and the multiple rows of magnetic rods 4331 are evenly spaced along the width direction of the first push plate 4334. The number of rows of magnetic rods 4331 is equal to the number of substrate reading holes to achieve the detection of multiple items, that is, to achieve multi-item detection.

[0159] There are multiple magnetic bars 4331 in each row, and the multiple magnetic bars 4331 in each row are evenly spaced along the length direction of the first push plate 4334. The number of magnetic bars 4331 in each row is equal to the number of multi-test reagent strips 20, thereby realizing multi-channel parallel processing of multiple multi-test reagent strips 20.

[0160] In an embodiment of the present invention, there are three rows of magnetic rods 4331, which can realize the detection of three items. The space occupied by the three rows of magnetic rods 4331 is not too large, and three items of detection can be realized. It can realize multi-detection while controlling the volume of the multi-channel multi-detection POCT fully automatic chemiluminescence device 100.

[0161] Of course, in other embodiments, the magnetic bars 4331 can also be arranged in 2 rows, 4 rows, or even more rows to enable detection of different numbers of items.

[0162] The sample pre-processing mechanism 43 of this embodiment of the utility model can reciprocate magnetic attraction by driving the magnetic rod 4331 upward and downward via the second drive element 432, thereby achieving higher efficiency in magnetic separation. The multi-channel parallel separation process further enhances the efficiency of magnetic particle separation and transfer. Furthermore, the reciprocating motion of the disposable magnetic separation sleeve 25, achieved by the second drive element 432, can also achieve mixing of the reaction solution and resuspension of the cleaning solution.

[0163] Exemplarily, the process of transferring magnetic particles by the sample pre-processing mechanism 43 is roughly as follows:

[0164] After the sample is injected into the corresponding reagent hole of the multi-test reagent strip 20, the reaction chamber assembly 30 drives the multi-test reagent strip 20 to move to the corresponding position, so that the sample pre-treatment mechanism 43 is located directly above the disposable magnetic rod 4331 set. At this time, the first driving element 411 drives the first mounting frame 431 to descend to a certain height until the disposable magnetic rod 4331 set is loaded on the first loading head 4333. The first driving element 411 drives the first mounting frame 431 to rise, and the disposable magnetic rod 4331 set is driven by the first loading head 4333 to rise to a certain height.

[0165] Afterwards, the reaction chamber assembly 30 moves until the sample pre-treatment assembly 433 loaded with the disposable magnetic rod 4331 set moves to the top of the corresponding hole position of the multi-detection reagent strip 20, and the second driving element 432 drives the magnetic rod 4331 to descend until the magnetic rod 4331 contacts the bottom of the disposable magnetic separation sleeve 25. At this time, the first driving element 411 drives the first mounting bracket 431 to descend to a certain height, so that the disposable magnetic rod 4331 set extends into the liquid containing magnetic particles (such as the magnetic labeled ligand above) until the disposable magnetic rod 4331 set contacts the bottom of the magnetic labeled ligand hole, so that the magnetic particles are gradually adsorbed to the end of the disposable magnetic separation sleeve 25. The adsorption of the magnetic particles can be fully completed by slowly lifting and lowering multiple times.

[0166] After the adsorption of the magnetic particles is completed, the first driving element 411 is controlled to drive the first mounting bracket 431 to rise. At this time, all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve 25. The reaction chamber assembly 30 is controlled to move until the disposable magnetic separation sleeve 25 is located above the cleaning liquid. The first driving element 411 drives the first mounting bracket 431 to descend until the disposable magnetic separation sleeve 25 extends into the cleaning liquid. Afterwards, the second driving element 432 drives the magnetic rod 4331 to rise from the disposable magnetic separation sleeve 25, causing the magnetic field to disappear. The magnetic particles are separated from the outer wall of the disposable magnetic separation sleeve 25 and fall off, entering the cleaning liquid.

[0167] To accelerate the separation of the magnetic particles, the first drive element 411 can repeatedly raise and lower the first mounting frame 431 at different frequencies, causing the magnetic particles to repeatedly move in the cleaning solution, thereby ensuring that the magnetic particles and the cleaning solution are fully mixed and suspended. After the magnetic particles are completely separated from the outer wall of the disposable magnetic separation sleeve 25, the first drive element 411 drives the first mounting frame 431 to rise to its initial height, completing the separation, cleaning, and mixing operations. If multiple magnetic separation and cleaning operations are required, the above steps can be repeated.

[0168] Similarly, if it is necessary to transfer the magnetic particles to other hole positions, just control the first driving element 411 to drive the first mounting bracket 431 to descend until the disposable magnetic separation sleeve 25 extends to the bottom of the corresponding liquid surface, and then control the second driving element 432 to drive the magnetic rod 4331 to descend until it contacts the bottom end of the disposable magnetic separation sleeve 25, so that all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve 25, and control the first driving element 411 to drive the first mounting bracket 431 to rise.

[0169] Afterwards, the reaction chamber assembly 30 is controlled to move until the disposable magnetic separation sleeve 25 adsorbed with magnetic particles moves to the top of the target hole, and then the first driving element 411 is controlled to drive the first mounting bracket 431 to descend until the disposable magnetic separation sleeve 25 extends into the target liquid. At this time, the second driving element 432 is controlled to drive the magnetic rod 4331 to rise so that the magnetic field disappears, and the magnetic particles can be gradually separated into the target liquid. The first driving element 411 can be controlled to repeatedly drive the first mounting bracket 431 to rise and fall, so that the disposable magnetic separation sleeve 25 repeatedly moves in the target liquid to accelerate the separation of the magnetic particles.

[0170] See also Figures 6 to 11 and Figure 13 Furthermore, the sample extraction mechanism 42 includes:

[0171] A second mounting frame 421 is provided on the gantry 41 and is in transmission connection with the first driving element 411. The first driving element 411 can drive the second mounting frame 421 to move up and down;

[0172] a third driving element 422 disposed on the second mounting bracket 421; and

[0173] The extraction component 423 is mounted on the second mounting frame 421 and is in transmission connection with the third driving element 422 . The third driving element 422 can drive the extraction component 423 to move up and down to aspirate and discharge samples.

[0174] Specifically, the first drive element 411 can drive the second mounting frame 421 to rise and fall, thereby driving the sample extraction mechanism 42 to rise and fall, thereby performing corresponding processing such as aspirating and discharging samples from the multi-test reagent strip 20. The second mounting frame 421 can be roughly L-shaped, comprising a two-part structure, such as a horizontal extension plate and a vertical extension plate. The third drive element 422 can be mounted on the horizontal extension plate to ensure a stable installation, thereby providing stable power for the lifting and lowering of the extraction assembly 423.

[0175] The extraction component 423 is arranged on the vertical extension plate, and the third driving element 422 can be a screw motor. The screw motor has high movement accuracy and is more accurate and stable in position adjustment. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the extraction component 423. The transmission connection between the two can be a threaded connection, which can ensure the stability of the connection between the two. At the same time, the third driving element 422 can make the extraction component 423 move smoothly and accurately in the vertical direction through threaded driving, so as to smoothly and accurately aspirate the sample after contacting the sample.

[0176] In addition, a second detector (such as a photoelectric switch) can be set on one side of the top of the gantry 41, and a second sensing element (such as a baffle) can be set on one side of the top of the second mounting bracket 421. The second sensing element can generate or disconnect sensing with the second detector as the second mounting bracket 421 rises and falls.

[0177] When the second mounting bracket 421 drives the second sensing element to move to the second detector to disconnect the sensing element, it indicates that the sample extraction mechanism 42 has moved to the set height. At this time, the power supply to the first driving element 411 can be disconnected to prevent the first driving element 411 from being overloaded and damaged, thereby saving power consumption.

[0178] Furthermore, a second slide 4211 may be provided on the side of the second mounting frame 421 facing the gantry 41 , and a second slide rail 415 extending along the height direction of the gantry 41 may be provided on the side of the gantry 41 facing the second mounting frame 421 , and the second slide 4211 is slidably connected to the second slide rail 415 .

[0179] The second slides 4211 and second rails 415 are provided in two sets, one on each side of the gantry 41 and the other on the left and right sides of the second mounting frame 421. The cooperation of the two sets of second slides 4211 and second rails 415 ensures that the first drive element 411 drives the second mounting frame 421 to rise and fall smoothly on the gantry 41, thereby ensuring smooth and accurate lifting of the sample extraction mechanism 42.

[0180] See also Figure 13 , further, the extraction component 423 includes:

[0181] An injection device 4231 is mounted on the second mounting frame 421. A plurality of injection cavities are formed in the injection device 4231. A plurality of second loading heads 4232 for loading the tip heads 24 are provided at the bottom of the injection device 4231. The plurality of second loading heads 4232 are in one-to-one communication with the plurality of injection cavities.

[0182] a second push plate 4233 disposed above the injection device 4231 , the second push plate 4233 being in driving connection with the third driving element 422 ; and

[0183] Multiple piston rods 4234 are provided on the second push plate 4233. The piston rods 4234 are movably and sealedly connected to the syringe cavity. The third driving element 422 can drive the second push plate 4233 to drive the piston rods 4234 to rise and fall in the syringe cavity to perform suction and exhalation actions.

[0184] Specifically, the injection device 4231 is generally rectangular and extends along the width of the second mounting frame 421, thereby allowing the syringe cavity therein to be distributed across the width of the extraction assembly 423 to correspond to the location of the multi-test reagent strip 20. The injection device 4231 also has a certain height to ensure that the syringe cavity is sufficiently large, allowing the piston rod 4234 to generate sufficient suction and discharge force when moving within the syringe cavity.

[0185] The second loading head 4232 and the tip 24 form an interference fit, ensuring the stability of the tip 24 when mounted on the second loading head 4232. When the first drive element 411 drives the second mounting bracket 421 to lower the extraction assembly 423, the tip 24 mounted on the second loading head 4232 can break the corresponding sealing film on the multi-test reagent strip 20. The second loading head 4232 is connected to the syringe cavity, connecting the syringe cavity to the tip 24. When the piston rod 4234 is pushed up and down in the syringe cavity, the sample can be aspirated and discharged through the tip 24.

[0186] The transmission shaft of the third driving element 422 extends downward through the top of the second mounting bracket 421 and the second push plate 4233. A fixing piece threadedly connected to the transmission shaft can be provided on the transmission shaft, and the second push plate 4233 can be fixed to the fixing piece. When the transmission shaft of the third driving element 422 moves, the fixing piece can be used to drive the second push plate 4233 to move up and down, thereby realizing the lifting and lowering of the piston rod 4234.

[0187] Alternatively, a screw hole can be set on the second push plate 4233, and a thread can be set on the transmission shaft of the third driving element 422. The transmission shaft is threadedly connected to the second push plate 4233. This can ensure the stability of the connection between the two, and the third driving element 422 can also drive the second push plate 4233 to rise and fall by thread driving.

[0188] In this embodiment, the end of the piston rod 4234 in the syringe cavity can be sealed with the syringe cavity by a sealing ring (such as a rubber ring or plastic ring). When the piston rod 4234 is driven upward by the second push plate 4233 and rises in the syringe cavity, negative pressure is generated in the syringe cavity, causing the tip 24 to absorb the sample. When the piston rod 4234 is pushed downward by the second push plate 4233 and descends in the syringe cavity, positive pressure is generated in the syringe cavity, causing the tip 24 to discharge the sample.

[0189] Furthermore, to ensure that the second push plate 4233 smoothly drives the piston rod 4234 up and down, a vertically extending slide rail is provided on the injection device 4231, and a slider adapted to the slide rail is provided on the second push plate 4233. The cooperation between the slide rail and the slider ensures stable movement of the second push plate 4233 relative to the second mounting frame 421, thereby ensuring stable driving of the piston rod 4234. The slide rail and the slider are provided in two sets, one on the left and one on the right side of the sample extraction mechanism 42, further ensuring smooth raising and lowering of the second push plate 4233.

[0190] Furthermore, a photoelectric switch can be set on the top of the second mounting bracket 421, and a baffle can be set on the corresponding side of the second push plate 4233. When the second push plate 4233 drives the baffle to move to the photoelectric switch so that the photoelectric switch disconnects the sensing, it indicates that the second push plate 4233 has moved to the set height, that is, the piston rod 4234 has been reset. At this time, the power supply of the third driving element 422 can be disconnected to prevent the third driving element 422 from being overloaded and damaged.

[0191] Please combine Figure 9 and Figure 13 In an embodiment of the present invention, multiple syringe cavities are evenly spaced along the length direction of the injection device 4231; multiple second loading heads 4232 are evenly spaced along the length direction of the injection device 4231; multiple piston rods 4234 are evenly spaced along the length direction of the second push plate 4233; that is, multiple piston rods 4234, multiple syringe cavities and multiple piston rods 4234 correspond one to one, thereby realizing multi-channel parallel processing of multiple multi-test reagent strips 20.

[0192] Please continue reading Figure 13 Furthermore, the sample extraction mechanism 42 further includes:

[0193] A push rod 4235 is liftably disposed through the injection device 4231 , with the top end of the push rod 4235 spaced apart from the second push plate 4233 ;

[0194] The elastic element 4236 is sleeved on the push rod 4235 located in the injection device 4231, and the elastic element 4236 is simultaneously stretched or compressed when the push rod 4235 is raised or lowered relative to the injection device 4231; and

[0195] A separation plate 4237 is provided at the bottom of the injection device 4231 , and the second loading head 4232 passes through the separation plate 4237 . The bottom end of the push rod 4235 is connected to the separation plate 4237 , and the push rod 4235 can drive the separation plate 4237 to rise and fall relative to the second loading head 4232 .

[0196] In an embodiment of the present invention, a through hole is provided on the separation plate 4237, the size of which is smaller than the size of the connection between the tip head 24 and the second loading head 4232. Therefore, the tip head 24 loaded on the second loading head 4232 can be removed by setting the separation plate 4237.

[0197] Specifically, since the top end of the push rod 4235 is spaced from the second push plate 4233, when the second push plate 4233 is pushed down a certain height by the third driving element 422 to contact the top end of the push rod 4235, the second push plate 4233 pushes the push rod 4235 to descend in the injection device 4231, thereby pushing the separation plate 4237 located at the bottom of the injection device 4231 to descend and collide with the tip head 24, so as to push the tip head 24 to separate from the second loading head 4232.

[0198] After the tip 24 is separated, the third driving element 422 stops driving, and the elastic element 4236 expands, exerting an upward force on the push rod 4235, thereby resetting the separation plate 4237. The compression of the elastic element 4236 provides a certain buffer for the descent of the push rod 4235, preventing the push rod 4235 from descending too quickly and causing damage to the tip 24, or preventing the tip 24 from pressing against the multi-test test strip 20 and causing the multi-test test strip 20 to shift or shake.

[0199] In an embodiment of the present invention, there are two push rods 4235 and elastic elements 4236, which are respectively arranged on both sides of the injection device 4231 to ensure that the push rod 4235 pushes the separation plate 4237 smoothly, thereby ensuring the separation effect of the tip head 24, and ensuring that the elastic element 4236 smoothly resets the separation plate 4237.

[0200] Exemplarily, the process of the sample extraction mechanism 42 aspirating and discharging the sample (and transferring / mixing the reagent) is roughly as follows:

[0201] The reaction chamber assembly 30 drives the multiple test reagent strip 20 to move to the corresponding position, and the first driving element 411 drives the second mounting frame 421 to descend until the second loading head 4232 cooperates with the tip head 24 on the multiple test reagent strip 20 and is fixed.

[0202] After the tip 24 is loaded, the reaction chamber assembly 30 drives the multi-test reagent strip 20 to move until the tip 24 moves above the sample well 23. Simultaneously, the third drive element 422 first drives the piston rod 4234 down a certain height or to the lowest point within the syringe chamber. The first drive element 411 then drives the second mounting bracket 421 down a certain height until the tip of the tip 24 enters the sample. The third drive element 422 then drives the piston rod 4234 up to aspirate the sample through the tip 24. The first drive element 411 then drives the second mounting bracket 421 up, freeing the tip 24 from the sample liquid surface. The reaction chamber assembly 30 then drives the multi-test reagent strip 20 to move until the tip 24, now loaded with the sample, moves directly above the target well.

[0203] The first drive element 411 drives the second mounting frame 421 downward, driving the sample-laden tip 24 down until its tip extends below the reagent liquid level. The third drive element 422 drives the piston rod 4234 downward to inject the sample from the tip 24 into the reagent. The first drive element 411 then drives the second mounting frame 421 upward until the tip 24 is separated from the reagent. The third drive element 422 then drives the piston rod 4234 upward to its original position, completing the sample aspiration and transfer process. The tip 24 is then retracted into the tip hole.

[0204] The reagent transfer process is the same as the sample transfer process and will not be described in detail here.

[0205] If multiple pipetting operations are required, the tip 24 can be repeatedly loaded and the aspiration and injection operations can be repeated. Furthermore, the sample extraction mechanism 42 can also be used to mix the reagents. By controlling the third drive element 422 to repeatedly raise and lower the piston rod 4234 within the syringe cavity, the tip 24 can be repeatedly aspirated and discharged below the reagent liquid level, thereby fully mixing the reagents or samples to be reacted.

[0206] See also Figure 8 、 Figure 10 and Figure 11 Furthermore, a movable space 412 is provided on the gantry 41, and the transmission shaft of the first driving element 411 passes through the movable space 412. A transmission plate 413 is sleeved on the transmission shaft, and a thread is provided on the transmission shaft, and a screw hole is provided on the transmission plate 413. Therefore, when the transmission shaft moves, the transmission plate 413 can be synchronously raised and lowered in the movable space 412 through thread transmission.

[0207] In addition, a first connecting portion is provided on the side of the first mounting frame 431 facing the gantry 41, and the first connecting portion is formed by a vertical extension plate of the first mounting frame 431 extending toward the gantry 41. A second connecting portion is provided on the side of the second mounting frame 421 facing the gantry 41, and the second extension portion is formed by a vertical extension plate of the second mounting frame 421 extending toward the gantry 41. The first connecting portion and the second connecting portion are both connected to the transmission plate 413 by fasteners (such as screws). Therefore, when the transmission plate 413 is raised and lowered along with the transmission shaft of the first driving element 411, the second mounting frame 421 and the first mounting frame 431 can be driven to rise and fall, thereby realizing the lifting and lowering of the sample extraction mechanism 42 and the sample pre-processing mechanism 43 on the gantry 41.

[0208] See also Figure 2 、 Figure 3 and Figure 14 Furthermore, the reaction chamber assembly 30 includes:

[0209] A guide rail 31 provided on the bottom plate of the mounting frame 10;

[0210] A reaction chamber body 32 is mounted on the guide rail 31. A guide block is provided at the bottom of the reaction chamber body 32 for slidingly connecting to the guide rail 31. The reaction chamber body 32 is provided with a plurality of evenly spaced receiving slots 33 for loading the multi-test reagent strips 20. The receiving slots 33 extend along the length of the reaction chamber body 32.

[0211] A fourth drive element 34 is provided on the bottom plate of the mounting frame 10 and at the rear end of the guide rail 31, and a first driving pulley is provided on the transmission shaft of the fourth drive element 34;

[0212] A mounting base 35 is provided on the bottom plate of the mounting frame 10 and at the front end of the guide rail 31. The mounting base 35 is provided with a first driven pulley 36. The first driving pulley is connected to the first driven pulley 36 via a belt.

[0213] A first synchronous belt pressure plate is provided on one side of the reaction chamber body 32 , and the first synchronous belt pressure plate is connected to the belt.

[0214] Specifically, the guide rail 31 extends along the length direction of the mounting frame 10. Through the sliding connection between the guide rail 31 and the guide block, the reaction chamber assembly 30 can move smoothly along the length direction of the mounting frame 10. The shape of the accommodating groove 33 is adapted to the shape of the multi-test reagent strip 20, so that the multi-test reagent strip 20 can be stably loaded on the reaction chamber assembly 30, maintaining stability during the movement and pre-processing process, avoiding deviation and shaking, and preventing reagents from leaking from the multi-test reagent strip 20.

[0215] The fourth driving element 34 is located at the rear end of the mounting frame 10, and the mounting seat 35 is located at the front end of the mounting frame 10, so that the connection between the two can cover the length direction of the mounting frame 10, so that the moving distance of the reaction chamber assembly 30 in the mounting frame 10 can be long enough to better cooperate with the movement of the multi-channel multi-inspection parallel pre-processing device 40.

[0216] The transmission structure composed of the first driving pulley, the belt, the first synchronous belt pressure plate and the first driven pulley 36 has high transmission efficiency, simple structure and sufficient power. Combined with the setting of the guide rail 31, it can ensure that the reaction chamber assembly 30 moves stably and quickly in the installation frame 10, thereby improving the movement efficiency of the reaction assembly.

[0217] Furthermore, a photoelectric switch for detecting the position of the reaction chamber body 32 in real time may be provided on the bottom plate of the mounting frame 10, and a baffle may be provided on the reaction chamber body 32. When the reaction chamber body 32 drives the baffle to move to the corresponding position, the baffle reaches the photoelectric switch and causes the photoelectric switch to disconnect the sensing, indicating that the reaction chamber assembly 30 has reached the set position. At this time, the power supply of the fourth drive element 34 can be disconnected to avoid overload and failure caused by continuous operation of the fourth drive element 34, and also save power consumption.

[0218] In addition, a heating module is provided at the bottom of the reaction chamber body 32. The heating temperature of the heating module can be kept constant at human body temperature, i.e., 37°C. The temperature inside the reaction chamber body 32 is kept constant within a preset value range, thereby ensuring that the reagents in the multi-detection reagent strip 20 meet the temperature conditions for chemiluminescence determination.

[0219] See also Figure 2 、 Figure 15 and Figure 16 , further, the PMT assembly 60 includes:

[0220] A mounting bracket 61 provided on the bottom plate of the mounting frame 10;

[0221] a third mounting bracket 62 provided on the mounting bracket 61;

[0222] a fourth mounting bracket 63 provided at the bottom of the third mounting bracket 62;

[0223] A PMT module 64 is mounted on a fourth mounting bracket 63;

[0224] A fifth driving element 65 is provided on the top of the third mounting frame 62 and is in transmission connection with the fourth mounting frame 63. The fifth driving element 65 can drive the fourth mounting frame 63 to move up and down, thereby driving the PMT module 64 to move up and down;

[0225] A sixth driving element 66 and a second driven pulley 67 are respectively provided on both sides of the top of the mounting bracket 61. The transmission shaft of the sixth driving element 66 is provided with a second driving pulley, and the second driving pulley is connected to the second driven pulley 67 via a belt; and

[0226] The second synchronous belt pressure plate 68 is provided on the third mounting bracket 62 and is connected to the belt.

[0227] In this embodiment of the present invention, the structure of the mounting bracket 61 can be similar to that of the gantry 41, also spanning the width of the mounting frame 10, thereby enabling the PMT module 64 to move above the reaction chamber assembly 30 to perform chemiluminescence detection. Furthermore, the mounting bracket 61 can be made of a metal material, such as stainless steel, iron, aluminum, or various alloys, which provides high strength and can extend the service life of the PMT assembly 60.

[0228] The third mounting bracket 62 is used to mount the fifth drive element 65, providing stable support for the fifth drive element 65 and ensuring its stable position atop the mounting bracket 61. The fourth mounting bracket 63 is used to mount the PMT module 64. It is in driving connection with the fifth drive element 65, enabling the PMT module 64 to move up and down under the drive of the fifth drive element 65. The third mounting bracket 62 is connected to a belt drive, driving the fourth mounting bracket 63 and the PMT module 64 mounted thereon horizontally. The fifth drive element 65 and the sixth drive element 66 are coupled to enable the PMT module 64 to move up, down, left, and right on the mounting bracket 61.

[0229] In an embodiment of the present utility model, the fifth driving element 65 can be a screw motor, which drives the fourth mounting bracket 63 to rise and fall through the fifth driving element 65 arranged on the top of the mounting bracket 61, thereby driving the PMT module 64 to rise and fall, so that the PMT component 60 can be close to or away from the multi-detection reagent strip 20, and the screw motor has high movement accuracy, and the position adjustment of the PMT module 64 is more accurate and stable, so that the PMT component 60 can accurately and stably detect the luminescence value of the detection position on the multi-detection reagent strip 20.

[0230] The sixth driving element 66 can be a stepper motor, which is located on one side of the top of the mounting bracket 61 (such as the right side), and the second driven pulley 67 is located on the other side of the top of the mounting bracket 61 (such as the left side), so that the connection between the two can cover the length direction of the mounting bracket 61, so that the movement of the PMT module 64 on the mounting bracket 61 can cover the width range of the mounting frame 10.

[0231] The transmission structure composed of the second driving pulley, the belt, the second synchronous belt pressure plate 68 and the second driven pulley 67 has high transmission efficiency, simple structure, sufficient power, and the belt can increase the moving speed of the PMT module 64 and thus improve the detection efficiency, so that the PMT assembly 60 can quickly move and switch between the various multi-detection reagent strips 20 in the reaction chamber assembly 30 to perform luminescence value detection respectively.

[0232] See also Figure 2 、 Figure 15 and Figure 16 Furthermore, the membrane rupturing component 50 includes:

[0233] a seventh driving element 51 disposed on top of the mounting bracket 61;

[0234] a fifth mounting frame 52 disposed on the mounting bracket 61 and located below the seventh driving element 51 , the fifth mounting frame 52 being in driving connection with the seventh driving element 51 and being capable of being raised and lowered by the seventh driving element 51 ; and

[0235] A plurality of membrane breaking heads 53 are provided at the bottom of the fifth mounting frame 52 , and the plurality of membrane breaking heads 53 are evenly spaced along the length direction of the fifth mounting frame 52 .

[0236] In this embodiment of the present invention, the membrane rupture assembly 50 and the PMT assembly 60 share a mounting bracket 61, which improves the utilization of the mounting bracket 61, controls the internal volume of the device, and promotes device miniaturization. The membrane rupture assembly 50 is located on the side of the mounting bracket 61 closest to the multi-channel, multi-test parallel pre-processing device 40. This position, closer to the multi-test reagent strip 20, shortens the travel distance of the multi-test reagent strip 20, allows for faster membrane rupture of the common liquid region 2112, and improves the device's analysis efficiency.

[0237] The seventh drive element 51 can be a screw motor. The seventh drive element 51, located at the top of the mounting bracket 61, drives the fifth mounting bracket 52 up and down, thereby driving the membrane rupturing head 53 up and down. This allows the membrane rupturing head 53 to move closer to or further away from the multi-test reagent strip 20. The sharp end of the membrane rupturing head 53 can then be used to rupture the sealing film and switch the ruptured film between different reagent wells. Furthermore, the high precision of the screw motor allows for more accurate and stable position adjustment of the membrane rupturing head 53, enabling the membrane rupturing head 53 to accurately and stably rupture the sealing film of the common liquid area 2112, avoiding pressure on the multi-test reagent strip 20 and causing shaking and misalignment.

[0238] The number of membrane rupturing heads 53 is equal to the number of multi-test reagent strips 20, allowing for simultaneous rupturing of all multi-test reagent strips 20, thereby increasing processing speed and, consequently, the analytical efficiency of the device. Furthermore, the membrane rupturing heads 53 can be arranged in multiple rows, for example, with the number of rows being equal to the number of reagent wells in the common liquid area 2112. In this manner, the membrane rupturing assembly 50 only requires a single operation to rupture all the sealing films of the common liquid area 2112, thereby improving membrane rupturing efficiency and, consequently, the analytical efficiency of the device.

[0239] In an embodiment of the present utility model, the transmission shaft of the seventh driving element 51 extends downward through the top of the fifth mounting bracket 52. A fixing piece threadedly connected to the transmission shaft can be provided on the transmission shaft, and the fifth mounting bracket 52 can be fixed on the fixing piece. When the transmission shaft of the seventh driving element 51 moves, the fifth mounting bracket 52 can be driven to rise and fall through the fixing piece to realize the lifting and lowering of the membrane rupturing head 53.

[0240] Alternatively, a screw hole may be directly provided on the fifth mounting bracket 52, and a thread may be provided on the transmission shaft of the seventh driving element 51, so that the transmission shaft is threadedly connected to the fifth mounting bracket 52 (screw hole). This ensures the stability of the connection between the two, and the seventh driving element 51 can also drive the fifth mounting bracket 52 to rise and fall smoothly by threaded driving.

[0241] In an embodiment of the present invention, the membrane breaking head 53 and the fifth mounting bracket 52 can be detachably arranged. For example, the membrane breaking head 53 is mounted on the fifth mounting bracket 52 by screws, which not only ensures the stability of the membrane breaking head 53 on the fifth mounting bracket 52, but also facilitates disassembly and assembly, and is also convenient for replacement when the membrane breaking head 53 is damaged.

[0242] Furthermore, to ensure that the seventh drive element 51 smoothly drives the fifth mounting frame 52 to move upward and downward, a vertically extending slide rail can be provided on the mounting bracket 61, and a slider compatible with the slide rail can be provided on the fifth mounting bracket 52. The cooperation between the slide rail and the slider enables stable movement of the fifth mounting frame 52 relative to the mounting bracket 61. The slide rail and the slider are provided in two sets, one on the left and one on the right, further ensuring smooth raising and lowering of the fifth mounting frame 52.

[0243] Furthermore, a photoelectric switch can be provided on the top of the mounting bracket 61, and a baffle can be provided on the corresponding side of the fifth mounting bracket 52. When the fifth mounting bracket 52 drives the baffle to move to the photoelectric switch so that the photoelectric switch disconnects the sensing, it indicates that the fifth mounting bracket 52 has moved to the set height and reset. At this time, the power supply of the seventh driving element 51 can be disconnected, thereby avoiding overload and damage of the seventh driving element 51 and saving power consumption.

[0244] Furthermore, the multi-channel multi-detection POCT fully automatic chemiluminescence device 100 may also include components such as a control module, an electrical module, a display module, an image acquisition module, a heat dissipation module and an alarm module. The control module is electrically connected to the electrical module, the display module, the image acquisition module, the heat dissipation module and the alarm module, and the electrical module is also electrically connected to the display module, the image acquisition module, the heat dissipation module and the alarm module.

[0245] Exemplarily, the electrical module can be used to provide power support for the entire device, and the control module is used to control the operation of the device, such as controlling the opening and closing of each driving element, the opening and closing of the heating module, the display of the display module, and the image acquisition and image conversion of the image acquisition module. The display module can be used to display the operating parameters of the device and data such as project analysis results. The image acquisition module can be used to shoot and monitor the pre-processing work of the multi-channel multi-inspection parallel pre-processing device 40. When an abnormal operation is monitored, the control module can control the alarm module (such as sound and light alarm, display alarm, etc.) to issue a corresponding warning. The heat dissipation module is used to dissipate heat for the equipment to avoid overheating and affecting normal operation.

[0246] Components such as the control module, electrical module, display module, image acquisition module, heat dissipation module, and alarm module do not relate to the practical aspects of the present invention and are therefore not described in detail here. Their connection relationships and basic functions are simply explained. If any ambiguity remains, those skilled in the art are referred to the related art for the structure, location, and function of components such as control modules, electrical modules, display modules, image acquisition modules, heat dissipation modules, and alarm modules.

[0247] In this specification, references to terms such as "Example 1" and "Example 2" indicate that specific features, structures, materials, or characteristics described in conjunction with an embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of these terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0248] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A multi-channel multi-detection POCT fully automatic chemiluminescence device, characterized in that: include: Install the frame; a reaction chamber assembly disposed on the mounting frame and configured to load a multiple-test reagent strip, the reaction chamber assembly being reciprocally movable along the length of the mounting frame; the multiple-test reagent strip being configured to detect at least two markers; the multiple-test reagent strip comprising a liquid sealing area, the liquid sealing area comprising a common liquid area and a dedicated liquid area distributed along the length of the multiple-test reagent strip; A multi-channel multi-test parallel pre-processing device is provided on the mounting frame, the multi-channel multi-test parallel pre-processing device comprising at least two rows of magnetic bars arranged side by side along the movement direction of the reaction chamber assembly, each row of the magnetic bars having at least two magnetic bars, the at least two rows of the magnetic bars being used to transfer magnetic particles in adjacent wells of the multi-test reagent strip into the liquid sealing area; a membrane breaking assembly provided on the mounting frame and located at the rear end of the multi-channel multi-inspection parallel pre-processing device, the membrane breaking assembly being used to break the sealing film of the common liquid area; and The PMT component is provided on the mounting frame and located at the rear end of the membrane rupturing component. The reaction chamber component is used to move the multi-detection reagent strip to the PMT component. The PMT component is used to detect the luminescence value of the detection position of the multi-detection reagent strip.

2. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The multi-channel multi-joint detection parallel pre-processing device comprises: a gantry provided on the bottom plate of the mounting frame, wherein a first driving element is provided on the top of the gantry; a sample extraction mechanism disposed on the gantry, the sample extraction mechanism being in driving connection with the first driving element and capable of rising and falling under the drive of the first driving element to aspirate and discharge the sample on the multiple test strip; and A sample pre-processing mechanism is provided on the gantry, the sample pre-processing mechanism is in transmission connection with the first driving element and can be raised and lowered under the drive of the first driving element, and at least two rows of magnetic bars are provided on the sample pre-processing mechanism.

3. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 2, characterized in that: The sample pre-processing mechanism includes: A first mounting frame provided on the gantry and in transmission connection with the first driving element, wherein the first driving element can drive the first mounting frame to rise and fall; a second driving element disposed on the first mounting bracket; and A pre-processing component is arranged on the first mounting frame and is transmission-connected to the second driving element, at least two rows of magnetic rods are arranged on the pre-processing component and are transmission-connected to the second driving element, and the second driving element can drive at least two rows of magnetic rods to rise and fall to transfer magnetic particles.

4. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 3, characterized in that: The pre-processing component includes: A magnetic bar device is provided on the first mounting frame, wherein a plurality of movable through holes are formed in the magnetic bar device, and a plurality of first loading heads for loading disposable magnetic separation sleeves are provided at the bottom of the magnetic bar device, wherein the plurality of first loading heads are in one-to-one communication with the plurality of movable through holes; a first push plate disposed above the magnetic bar device, the first push plate being in driving connection with the second driving element; and There are multiple connecting rods arranged on the first push plate, and at least two rows of magnetic bars are arranged one by one on the free ends of the multiple connecting rods. The second driving element can drive the first push plate to drive the magnetic bars to rise and fall in the corresponding movable through holes so as to be separated from or pass through the first loading head.

5. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 4, characterized in that: The magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly distributed along the width direction of the first push plate; There are multiple magnetic bars in each row, and the multiple magnetic bars in each row are evenly distributed along the length direction of the first push plate.

6. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 3, characterized in that: The sample extraction mechanism includes: A second mounting frame provided on the gantry and in transmission connection with the first driving element, wherein the first driving element can drive the second mounting frame to rise and fall; a third driving element disposed on the second mounting bracket; and An extraction component is arranged on the second mounting frame and is transmission-connected to the third driving element. The third driving element can drive the extraction component to rise and fall to aspirate and discharge samples.

7. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The extraction component includes: An injection device is provided on the second mounting frame, wherein a plurality of injection cavities are formed in the injection device, and a plurality of second loading heads for loading tip heads are provided at the bottom of the injection device, wherein the plurality of second loading heads are in one-to-one communication with the plurality of injection cavities; a second push plate disposed above the injection device, the second push plate being in transmission connection with the third driving element; and A plurality of piston rods are provided on the second push plate, and the piston rods are movably and sealedly connected to the syringe cavity. The third driving element can drive the second push plate to drive the piston rods to move up and down in the syringe cavity to perform a suction and exhalation action.

8. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 7, characterized in that: The sample extraction mechanism further includes: A push rod is lifted and lowered through the injection device, wherein the top end of the push rod is spaced apart from the second push plate; an elastic element sleeved on the push rod in the injection device, wherein the elastic element is simultaneously extended or compressed when the push rod is raised or lowered relative to the injection device; and A separation plate is provided at the bottom of the injection device, the second loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the second loading head.

9. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 7, characterized in that: The plurality of syringe cavities are evenly distributed along the length direction of the injection device, the plurality of second loading heads are evenly distributed along the length direction of the injection device, and the plurality of piston rods are evenly distributed along the length direction of the second push plate.

10. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The sample extraction mechanism is opposite to the sample pre-processing mechanism and is located in front of the sample pre-processing mechanism. The first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

11. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The gantry is provided with an activity space, the transmission shaft of the first driving element passes through the activity space, and a transmission plate is sleeved on the transmission shaft. When the transmission shaft moves, the transmission plate can be raised and lowered in the activity space; A first connecting portion is provided on a side of the first mounting frame facing the gantry, and a second connecting portion is provided on a side of the second mounting frame facing the gantry. Both the first connecting portion and the second connecting portion are connected to the transmission plate.

12. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: A first slide is provided on a side of the first mounting frame facing the gantry frame, and a first slide rail is provided on a side of the gantry frame facing the first mounting frame. The first slide rail extends along the height direction of the gantry frame, and the first slide is slidably connected to the first slide rail. A second slide is provided on the side of the second mounting frame facing the gantry frame, and a second slide rail is provided on the side of the gantry frame facing the second mounting frame. The second slide rail extends along the height direction of the gantry frame, and the second slide is slidably connected to the second slide rail.

13. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 6, characterized in that: A first sensing member is provided on one side of the top of the first mounting frame, and a first detector is provided on one side of the top of the gantry frame. The first sensing member can generate or disconnect induction with the first detector as the first mounting frame rises or falls; A second induction member is provided on one side of the top of the second mounting frame, and a second detector is provided on one side of the top of the gantry frame. The second induction member can generate or disconnect induction with the second detector as the second mounting frame rises and falls.

14. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The reaction chamber assembly comprises: A guide rail provided on the bottom plate of the mounting frame; A reaction chamber body is provided on the guide rail, wherein a guide block is provided at the bottom of the reaction chamber body and is slidably connected to the guide rail. The reaction chamber body is provided with a plurality of evenly spaced receiving grooves for loading the multi-test reagent strips, and the receiving grooves extend along the length direction of the reaction chamber body; a fourth driving element disposed on the bottom plate of the mounting frame and located at the rear end of the guide rail, wherein a first driving pulley is disposed on a transmission shaft of the fourth driving element; a mounting base provided on the bottom plate of the mounting frame and located at the front end of the guide rail, wherein the mounting base is provided with a first driven pulley, and the first driving pulley is connected to the first driven pulley via a belt; and A first synchronous belt pressure plate is provided on one side of the reaction chamber body, and the first synchronous belt pressure plate is connected to a belt.

15. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The PMT assembly includes: a mounting bracket provided on the bottom plate of the mounting frame; a third mounting bracket provided on the mounting bracket; a fourth mounting bracket provided at the bottom of the third mounting bracket; A PMT module provided on the fourth mounting frame; A fifth driving element is provided on the top of the third mounting frame and is transmission-connected to the fourth mounting frame, wherein the fifth driving element can drive the fourth mounting frame to move up and down to drive the PMT module to move up and down; a sixth driving element and a second driven pulley respectively provided on both sides of the top of the mounting bracket, wherein a second driving pulley is provided on the transmission shaft of the sixth driving element, and the second driving pulley is connected to the second driven pulley via a belt; and A second synchronous belt pressure plate is arranged on the third mounting frame, and the second synchronous belt pressure plate is connected to the belt.

16. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 15, characterized in that: The membrane rupture component comprises: a seventh driving element disposed on the top of the mounting bracket; a fifth mounting bracket provided on the mounting bracket and located below the seventh driving element, the fifth mounting bracket being in driving connection with the seventh driving element and capable of being raised and lowered by the seventh driving element; and A plurality of membrane breaking heads are provided at the bottom of the fifth mounting frame, and the plurality of membrane breaking heads are evenly distributed along the length direction of the fifth mounting frame.

17. The multi-channel multi-detection POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The multiple detection reagent strip comprises: a reagent strip body, wherein the liquid sealing area is provided on the reagent strip body; a handle provided at one end of the test strip body; and A sample well, a tip, at least two disposable magnetic separation sleeves, the dedicated liquid area, and the common liquid area are arranged on the test strip body in sequence from the handle to the other end of the test strip body; The dedicated liquid area includes at least two magnetic particle labeled ligands and at least two enzyme labeled ligands, and the public liquid area includes a cleaning liquid and a luminescent substrate liquid.

Images