Device for freezing, thawing and storing biopharmaceutical materials

Abstract

The utility model discloses a device for freezing, unfreezing and storing biopharmaceutical materials, and relates to the technical field of pharmaceutical production mechanical equipment, the device comprises a base and a box body fixedly connected to the top of the base, the cross section of the inner side wall of the box body is a regular octagon, and driving mechanisms are embedded in the four corners of the inner side wall of the box body; every two adjacent driving mechanisms are arranged in a staggered mode, and every two opposite driving mechanisms are arranged in a central symmetry mode with respect to the axis of the inner side wall of the box body; according to the refrigerator, the blades at the air outlets or the air inlets of the fans are driven to swing through the driving mechanism, so that air in the refrigerator body circulates, the multiple fans work synchronously under the cooperation of the first connecting rod and the second connecting rod, meanwhile, the air is spread to corners more easily, the freezing efficiency is improved, and the heat transfer speed is increased; and the operation time of the refrigeration equipment is relatively shortened, and energy consumption is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical production machinery and equipment, in particular to a device for freezing, thawing and storing biopharmaceutical materials. Background Art

[0002] Biopharmaceutical materials refer to the raw materials used in the biopharmaceutical process. These materials are usually derived from natural organisms or their derivatives, or they can be artificially synthesized through biotechnology. Biopharmaceutical materials play an important role in the biopharmaceutical industry and are the basis for the manufacture of biological drugs, including but not limited to microorganisms, human, animal, plant and marine organisms, genetically engineered products, etc.

[0003] Before pharmaceutical production, a large number of experiments are needed to determine whether such materials can be used to treat diseases, so these materials need to be preserved. According to the properties and requirements of biopharmaceutical materials, appropriate temperature and humidity need to be selected to store these materials. For example, some biological preparations need to be stored under refrigerated conditions of 2°C to 8°C, while others need to be stored at lower temperatures.

[0004] Most of the current storage methods use traditional low-temperature refrigerators and low-temperature cold storages to freeze biopharmaceutical materials. That is, containers containing biopharmaceutical materials are placed in low-temperature refrigerators and low-temperature cold storages for freezing. However, during freezing, the freezing speeds of materials located at different positions in the freezer are different. That is, the materials closer to the cold source will be frozen quickly, while the freezing time of materials farther away from the cold source will be relatively longer, which will lead to large differences in freezing time and uneven freezing degree of materials in the same batch.

[0005] In view of this, this application is hereby filed. Utility Model Content

[0006] The purpose of the present invention is to provide a device for freezing, thawing and storing biopharmaceutical materials to solve the problems raised in the above background technology.

[0007] In order to solve the above technical problems, the utility model provides a device for freezing, thawing and storing biopharmaceutical materials, comprising a base and a box body fixedly connected to the top of the base, the inner wall cross-section of the box body is a regular octagon, and the four corners of the inner wall of the box body are embedded with driving mechanisms, wherein two adjacent driving mechanisms are staggered, and the two opposite driving mechanisms are symmetrically arranged about the center axis of the inner wall of the box body, wherein the tops of the two driving mechanisms on the higher horizontal plane are fixedly connected with a connecting rod 1 with the same structure, and the tops of the two driving mechanisms on the lower horizontal plane are fixedly connected with a connecting rod 2 with the same structure, the connecting rod 1 and the connecting rod 2 have the same structure, the cross-section of the connecting rod 1 is an arc shape, the adjacent connecting rods 1 and 2 are horizontally staggered, the two ends of the side wall of the connecting rod 1 and the connecting rod 2 close to each other are fixedly connected with a vertical fixing plate, the outer arc wall of the fixing plate is tangent to the inner wall of the box, the outer wall of the fixing plate is fixedly connected with a horizontal slide, and the end of the bottom of the slide away from the fixing plate is fixedly connected with an electric telescopic rod, and the electric telescopic rod is located in the box body.

[0008] Furthermore, a horizontal storage slot is provided at each of the four corners of the inner wall of the box body, and two adjacent storage slots are vertically staggered. The driving mechanism includes a fixed frame fixedly connected to the opening of the storage slot, and a protective shell is fixedly connected to the outer wall of one side of the fixed frame. The protective shell is a hollow structure, and a vertical channel is provided at one end of the top of the protective shell near the opening of the storage slot. A rack rod is slidably connected in the channel, and a plurality of gears equally spaced along the vertical direction are meshed and connected on the side of the rack rod away from the opening of the storage slot, and the plurality of gears are all located in the protective shell.

[0009] Furthermore, the ends of several of the gears away from the protective shell are fixedly connected to the rotating shaft 1, the ends of the rotating shaft 1 away from the gear pass through the fixed frame, the end of the rotating shaft 1 away from the gear is fixedly connected to the blade, the end of the blade away from the rotating shaft 1 is rotatably connected to the inner wall of the fixed frame, the top of the rack rod is fixedly connected to a horizontally arranged fixing rod, the fixing rod is located outside the protective shell, wherein the fixing rods on the two fixing frames at a higher horizontal plane are fixedly connected to the connecting rod 1, and the fixing rods on the two fixing frames at a lower horizontal plane are fixedly connected to the connecting rod 2, and a fan is installed on the end of the fixing frame away from the opening of the storage slot 1.

[0010] Furthermore, a vertical limit column is fixedly connected to the top center of the base, and a plurality of vertical slide grooves 1 distributed in a circular array are provided on the outer arc wall of the limit column. A plurality of storage trays are slidably connected to the outer side of the limit column, and a vertical channel 2 is provided at the top center of the storage tray. A plurality of vertical sliding rods distributed in a circular array are fixedly connected to the inner arc wall of the channel 2, and the sliding rods are adapted to the slide groove 1.

[0011] Furthermore, a plurality of storage channels are provided on the top of the storage tray outside the second channel, and the cross-sectional radius of the opening of the storage channel on the side close to the base is greater than the cross-sectional radius of the opening on the side away from the base.

[0012] Furthermore, the length of the slide rod fixedly connected to the inner arc wall of the second channel on the storage tray is greater than the axial height of the storage tray, both ends of the slide rod are fixedly connected to magnetic blocks, and the limiting column is made of non-ferromagnetic material.

[0013] Furthermore, a top cover is installed on the top of the box, a refrigeration device is provided inside the base, the box is a hollow structure, a heat exchange tube is connected to the refrigeration device, the heat exchange tube is coiled inside the box, and the end of the storage slot away from the center of the box is connected to the inside of the box.

[0014] Furthermore, a second slide groove for the sliding plate to slide is provided on the inner side wall of the box body, and the fixed end of the electric telescopic rod is fixedly connected to the bottom inner wall of the second slide groove.

[0015] Compared with the prior art, the beneficial effects of the present invention are:

[0016] 1. The driving mechanism drives the blades of the fan outlet or inlet to swing, so that the air inside the box can circulate. With the cooperation of connecting rod 1 and connecting rod 2, multiple fans can work synchronously, and it is easier to spread air to the corners, thereby improving the freezing efficiency and accelerating the speed of heat transfer, thereby relatively reducing the operating time of the refrigeration equipment and reducing energy consumption.

[0017] 2. The storage tray can be conveniently mounted on the outer wall of the support column. The magnetic blocks with the same polarity at the ends of the sliding rods on adjacent storage trays can reduce the possibility of collision when placed. At the same time, multiple storage trays are convenient for classified storage, and the order of placement can be determined according to the properties of the materials, which is very practical. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a schematic diagram of the connection between the connecting rod and the fan in a device for freezing, thawing and storing biopharmaceutical materials;

[0019] Figure 2 for Figure 1 Exploded view of the structure at A in the middle;

[0020] Figure 3 A schematic diagram of the overall structure of an apparatus for freezing, thawing and storing biopharmaceutical materials;

[0021] Figure 4 A top view of the internal structure of a device for freezing, thawing and storing biopharmaceutical materials;

[0022] Figure 5Schematic diagram of the internal structure of a device used to freeze, thaw and store biopharmaceutical materials.

[0023] In the picture:

[0024] 10. Base; 11. Box body; 12. Top cover;

[0025] 20. Storage tray; 21. Limiting column;

[0026] 30. Connecting rod 1; 31. Fixed plate; 32. Connecting rod 2;

[0027] 40. Driving mechanism; 41. Fixed frame; 42. Blades; 43. Rack rod; 44. Gear;

[0028] 45. Protective shell; 46. Fan. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0030] See also Figure 1-5 The present invention provides a technical solution: comprising a base 10 and a box body 11 fixedly connected to the top of the base 10, wherein the cross section of the inner side wall of the box body 11 is a regular octagon, and the four corners of the inner side wall of the box body 11 are embedded with a driving mechanism 40, wherein the two adjacent driving mechanisms 40 are staggered, and the two opposite driving mechanisms 40 are symmetrically arranged about the axis center line of the inner side wall of the box body 11, wherein the tops of the two driving mechanisms 40 at a higher level are fixedly connected with a connecting rod 30 of the same structure, and the two driving mechanisms 4 at a lower level are fixedly connected with a connecting rod 30 of the same structure. 0 are fixedly connected with a connecting rod 2 32 of the same structure, and the connecting rod 1 30 has the same structure as the connecting rod 2 32. The cross section of the connecting rod 1 30 is an arc shape. The adjacent connecting rods 1 30 and 2 32 are horizontally staggered. Both ends of the side wall where the connecting rods 1 30 and 2 32 are close to each other are fixedly connected with a vertical fixing plate 31. The outer arc wall of the fixing plate 31 is tangent to the inner wall of the box body 11. The outer wall of the fixing plate 31 is fixedly connected with a horizontal slide. The end of the bottom of the slide away from the fixing plate 31 is fixedly connected with an electric telescopic rod, and the electric telescopic rod is located inside the box body 11;

[0031] The four corners of the inner wall of the box body 11 are each provided with a horizontal storage slot 1, and two adjacent storage slots 1 are vertically staggered. The driving mechanism 40 includes a fixed frame 41 fixedly connected to the opening of the storage slot 1, and a protective shell 45 is fixedly connected to the outer wall of one side of the fixed frame 41. The protective shell 45 is a hollow structure, and a vertically penetrating channel 1 is provided at one end of the top of the protective shell 45 near the opening of the storage slot 1. A rack rod 43 is slidably connected in the channel 1. The side of the rack rod 43 away from the opening of the storage slot 1 is meshed with a plurality of gears 44 distributed at equal intervals in the vertical direction. The plurality of gears 44 are all located in the protective shell 45;

[0032] The ends of several of the gears 44 away from the protective shell 45 are fixedly connected to the rotating shaft 1, and the end of the rotating shaft 1 away from the gear 44 passes through the fixed frame 41. The end of the rotating shaft 1 away from the gear 44 is fixedly connected to the blade 42, and the end of the blade 42 away from the rotating shaft 1 is rotatably connected to the inner wall of the fixed frame 41. The top of the rack rod 43 is fixedly connected to a horizontally arranged fixing rod, and the fixing rod is located outside the protective shell 45. The fixing rods on the two fixing frames 41 at a higher horizontal plane are fixedly connected to the connecting rod 1 30, and the fixing rods on the two fixing frames 41 at a lower horizontal plane are fixedly connected to the connecting rod 2 32. A fan 46 is installed on the end of the fixed frame 41 away from the opening of the storage slot 1.

[0033] It should be noted that the four drive mechanisms 40 are distributed in a circular array about the inner axis of the box body 11, and two adjacent drive mechanisms 40 are located at different horizontal planes to blow and freeze the reagent tubes on the placement trays 20 at different positions;

[0034] The connecting rod 1 30 and the connecting rod 2 32 are both arc-shaped, and their projections in the vertical direction overlap. The fixed plate 31 is installed at the overlapping position. The electric telescopic rod on the outer wall of the fixed plate 31 drives the fixed plate 31 to move, thereby driving the connecting rod 1 30 and the connecting rod 2 32 to move, and then drives the rack rod 43 to move to engage the gear 44 to rotate, thereby driving the blade 42 to rotate for angle adjustment;

[0035] The rack rod 43 is slidably connected to the outer wall of the fixed frame 41, and the top end of the rack rod 43 is slidably connected to the channel 1. When the fixed rod abuts against the top of the fixed frame 41, the blade 42 tilts toward the base 10 and reaches the maximum angle. A limit block is fixedly connected to the side wall of the rack rod 43. When the limit block abuts against the inner wall of the top of the protective shell 45, the blade 42 tilts toward the top cover 12 and reaches the maximum angle.

[0036] See also Figure 1-5The utility model provides a technical solution: a vertical limiting column 21 is fixedly connected to the center of the top of the base 10, and a plurality of vertical slide grooves 1 distributed in a circular array are provided on the outer arc wall of the limiting column 21. A plurality of storage trays 20 are slidably connected to the outer side of the limiting column 21. A vertical channel 2 is provided at the center of the top of the storage tray 20. A plurality of vertical sliding rods distributed in a circular array are fixedly connected to the inner arc wall of the channel 2, and the sliding rods are adapted to the slide groove 1;

[0037] The top of the storage tray 20 is provided with a plurality of storage channels outside the second channel. The cross-sectional radius of the opening of the storage channel on the side close to the base 10 is larger than the cross-sectional radius of the opening on the side away from the base 10.

[0038] The length of the slide rod fixedly connected to the inner arc wall of the second channel on the storage tray 20 is greater than the axial height of the storage tray 20. Both ends of the slide rod are fixedly connected to magnetic blocks, and the limiting column 21 is made of non-ferromagnetic material.

[0039] It should be noted that: in a possible embodiment, the sliding rod is a spring telescopic rod, the elastic potential energy of the spring in the spring telescopic rod is greater than the gravitational potential energy of the storage tray 20 itself, and magnetic blocks are fixedly connected to both ends of the spring telescopic rod. The polarity of the magnetic blocks at the ends close to each other on two adjacent spring telescopic rods is the same, and the magnetic repulsion between the two magnetic blocks is less than the elastic potential energy of the spring, that is, when multiple storage trays 20 are placed, the spring telescopic rod can avoid the impact on the storage tray 20 below during placement.

[0040] See also Figure 1-5 The utility model provides a technical solution: a top cover 12 is installed on the top of the box body 11, a refrigeration device is provided inside the base 10, the box body 11 is a hollow structure, a heat exchange pipe is connected to the refrigeration equipment, the heat exchange pipe is coiled inside the box body 11, and an end of the storage slot away from the center of the box body 11 is connected to the inside of the box body 11.

[0041] It should be noted that: a wiring pipe is provided inside the box body 11, the wiring pipe is not in contact with the heat exchange pipe, and a circuit for supplying power to four fans 46, namely electric telescopic rods, is provided inside the wiring pipe. An interface is provided on the outer wall fan of the base 10.

[0042] See also Figure 1-5 The utility model provides a technical solution: a second slide groove for sliding the skateboard is provided on the inner wall of the box body 11, and the fixed end of the electric telescopic rod is fixedly connected to the bottom inner wall of the second slide groove.

[0043] It should be noted that: an electric telescopic rod is provided on the outer wall of one of the fixed plates 31, and a slide with the same structure is fixedly connected to the outer wall of the remaining fixed plates 31. A vertical channel three is provided at the end of the slide away from the fixed plate 31, and a limit rod is slidably connected in the channel three.

[0044] Working principle:

[0045] Place the reagent tube containing the material to be frozen in the storage channel on the storage tray 20, align the slide rod with the slide groove, and place the storage tray 20 on the limit column 21. Stack multiple storage trays 20. Under the action of the magnetic block, adjacent slide rods will not produce hard collisions. Cover the top cover 12, start the refrigeration equipment in the base 10, and then start the drive mechanism 40 to accelerate the air flow. At the same time, the electric telescopic rod drives the fixed plate 31 to move in the vertical direction, thereby driving the blades 42 on the drive mechanism 40 to adjust the angle, further increasing air circulation and accelerating the freezing rate.

Claims

1. A device for freezing, thawing and storing biopharmaceutical materials, comprising a base (10) and a box (11) fixedly connected to the top of the base (10), wherein the inner side wall cross section of the box (11) is a regular octagon, and is characterized in that: The four corners of the inner wall of the box body (11) are embedded with driving mechanisms (40), wherein two adjacent driving mechanisms (40) are staggered, and the two opposite driving mechanisms (40) are symmetrically arranged about the axis of the inner wall of the box body (11), wherein the tops of the two driving mechanisms (40) at a higher level are fixedly connected with a connecting rod 1 (30) with the same structure, and the tops of the two driving mechanisms (40) at a lower level are fixedly connected with a connecting rod 2 (32) with the same structure, and the connecting rod 1 (30) and the connecting rod The two (32) have the same structure, the cross section of the connecting rod one (30) is an arc shape, the adjacent connecting rods one (30) and two (32) are arranged horizontally and staggered, and both ends of the side wall of the connecting rod one (30) and the connecting rod two (32) close to each other are fixedly connected with a vertical fixed plate (31), the outer arc wall of the fixed plate (31) is tangent to the inner wall of the box body (11), and the outer wall of the fixed plate (31) is fixedly connected with a horizontal slide, and the end of the bottom of the slide away from the fixed plate (31) is fixedly connected with an electric telescopic rod, and the electric telescopic rod is located in the box body (11).

2. The device for freezing, thawing and storing biopharmaceutical materials according to claim 1, characterized in that: The box body (11) is provided with a horizontal storage slot 1 at each of the four corners of the inner side wall, and two adjacent storage slots 1 are vertically staggered. The driving mechanism (40) includes a fixed frame (41) fixedly connected to the opening of the storage slot 1, and a protective shell (45) is fixedly connected to the outer side wall of one side of the fixed frame (41). The protective shell (45) is a hollow structure, and a vertically penetrating channel 1 is provided at one end of the top of the protective shell (45) near the opening of the storage slot 1. A rack rod (43) is slidably connected in the channel 1. The rack rod (43) is meshedly connected to a side away from the opening of the storage slot 1 with a plurality of gears (44) distributed at equal intervals in the vertical direction. The plurality of gears (44) are all located in the protective shell (45).

3. The device for freezing, thawing and storing biopharmaceutical materials according to claim 2, characterized in that: The ends of the plurality of gears (44) away from the protective shell (45) are fixedly connected to a rotating shaft 1, the end of the rotating shaft 1 away from the gear (44) passes through the fixed frame (41), the end of the rotating shaft 1 away from the gear (44) is fixedly connected to a blade (42), the end of the blade (42) away from the rotating shaft 1 is rotatably connected to the inner wall of the fixed frame (41), the top of the rack rod (43) is fixedly connected to a horizontally arranged fixed rod, the fixed rod is located outside the protective shell (45), wherein the fixed rods on the two fixed frames (41) at a higher horizontal plane are fixedly connected to the connecting rod 1 (30), and the fixed rods on the two fixed frames (41) at a lower horizontal plane are fixedly connected to the connecting rod 2 (32), and a fan (46) is installed at the end of the fixed frame (41) away from the opening of the storage slot 1.

4. The device for freezing, thawing and storing biopharmaceutical materials according to claim 1, wherein: A vertical limiting column (21) is fixedly connected at the center of the top of the base (10), and a plurality of vertical slide grooves 1 distributed in a circular array are provided on the outer arc wall of the limiting column (21). A plurality of storage trays (20) are slidably connected to the outer side of the limiting column (21), and a vertical channel 2 is provided at the center of the top of the storage tray (20). A plurality of vertical sliding rods distributed in a circular array are fixedly connected on the inner arc wall of the channel 2, and the sliding rods are adapted to the slide groove 1.

5. The device for freezing, thawing and storing biopharmaceutical materials according to claim 4, characterized in that: A plurality of storage channels are provided on the top of the storage tray (20) and located outside the second channel. The cross-sectional radius of the opening of the storage channel on the side close to the base (10) is larger than the cross-sectional radius of the opening on the side away from the base (10).

6. The device for freezing, thawing and storing biopharmaceutical materials according to claim 4, characterized in that: The length of the slide rod fixedly connected to the inner arc wall of the second channel on the storage tray (20) is greater than the axial height of the storage tray (20), and magnetic blocks are fixedly connected to both ends of the slide rod. The limiting column (21) is made of non-ferromagnetic material.

7. The device for freezing, thawing and storing biopharmaceutical materials according to claim 1, wherein: A top cover (12) is installed on the top of the box body (11), a refrigeration device is provided inside the base (10), the box body (11) is a hollow structure, a heat exchange tube is connected to the refrigeration device, the heat exchange tube is coiled inside the box body (11), and an end of the storage groove away from the center of the box body (11) is connected to the inside of the box body (11).

8. The device for freezing, thawing and storing biopharmaceutical materials according to claim 1, wherein: A second slide groove for the slide plate to slide is provided on the inner side wall of the box body (11), and the fixed end of the electric telescopic rod is fixedly connected to the bottom inner wall of the second slide groove.

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