Chlorogenic acid extraction device

Abstract

The utility model discloses a chlorogenic acid extraction device which comprises an extracting solution storage tank, a first nanofiltration membrane assembly, a concentrated solution storage tank, a simulated moving bed chromatographic separation system, a chlorogenic acid phase buffer tank, a second nanofiltration membrane assembly, a thermal concentration tank, a spray dryer and a chlorogenic acid storage tank, the concentrated solution storage tank and the chlorogenic acid phase buffer tank are respectively communicated with the first pH regulator storage tank and the second pH regulator storage tank. According to the device, stevia rebaudiana is extracted, concentrated and subjected to simulated moving bed chromatographic separation, a chlorogenic acid phase is separated out, then the chlorogenic acid phase is subjected to impurity removal and drying, a chlorogenic acid product is prepared, the device is simple in structure, and the extraction steps of chlorogenic acid are greatly simplified.

Description

Technical Field

[0001] The utility model relates to a preparation device of chlorogenic acid, in particular to a chlorogenic acid extraction device. Background Art

[0002] Chlorogenic acid is a depsipeptide produced by caffeic acid and quinic acid. It is a phenylpropanoid compound produced by plants through the shikimic acid pathway during aerobic respiration. It is an important biologically active substance with antibacterial, antiviral, white blood cell-increasing, liver-protecting and choleretic, anti-tumor, blood pressure-lowering, blood lipid-lowering, free radical-scavenging and central nervous system-stimulating effects.

[0003] Currently, chlorogenic acid is primarily produced by extracting it from plants. Stevia is rich in steviol glycosides and also contains a certain amount of chlorogenic acid. Therefore, extracting chlorogenic acid from stevia is of great significance. Utility Model Content

[0004] The technical problem to be solved by the present invention is: in view of the deficiencies in the prior art, a chlorogenic acid extraction device is provided, which concentrates stevia extract and performs simulated moving bed chromatography to separate the chlorogenic acid phase, and then removes impurities and dries the chlorogenic acid phase to obtain a chlorogenic acid product. The above-mentioned device has a simple structure and greatly simplifies the extraction steps of chlorogenic acid.

[0005] In order to solve the above technical problems, the technical solution of the utility model is:

[0006] A chlorogenic acid extraction device comprises an extract storage tank, a first nanofiltration membrane assembly, a concentrated liquid storage tank, a simulated moving bed chromatography separation system, a chlorogenic acid phase buffer tank, a second nanofiltration membrane assembly, a hot concentration tank, a spray dryer, and a chlorogenic acid storage tank; the concentrated liquid storage tank and the chlorogenic acid phase buffer tank are respectively connected to a first pH adjuster storage tank and a second pH adjuster storage tank.

[0007] Preferably, the first nanofiltration membrane assembly is also connected to a pure water storage tank.

[0008] Preferably, the permeate outlet of the first nanofiltration membrane assembly is connected to an ethanol solution recovery tank.

[0009] Preferably, the stevia phase outlet of the simulated moving bed chromatography separation system is connected to a macroporous adsorption resin column, a reverse osmosis system, an anion exchange resin column, a cation exchange resin column, a third nanofiltration membrane assembly, a drying tank and a stevia storage tank.

[0010] Preferably, the macroporous adsorption resin column is further connected to an acid solution storage tank and an alkali solution storage tank.

[0011] Preferably, the number of the macroporous adsorption resin columns is at least two, and at least two macroporous adsorption resin columns are arranged in series.

[0012] Preferably, the macroporous adsorption resin column is also connected to a decomposing agent storage tank.

[0013] Preferably, the mobile phase inlet of the simulated moving bed chromatography separation system is communicated with the pure water storage tank.

[0014] Due to the adoption of the above technical solution, the beneficial effects of the utility model are:

[0015] The utility model provides a chlorogenic acid extraction device, comprising an extract storage tank, a first nanofiltration membrane assembly, a concentrate storage tank, a simulated moving bed chromatography separation system, a chlorogenic acid phase buffer tank, a second nanofiltration membrane assembly, a hot concentration tank, a spray dryer, and a chlorogenic acid storage tank. The concentrate storage tank and the chlorogenic acid phase buffer tank are connected to a first pH adjuster storage tank and a second pH adjuster storage tank, respectively. This device uses stevia extract as raw material and combines nanofiltration membrane impurity removal with simulated moving bed chromatography to produce a chlorogenic acid product, simplifying the chlorogenic acid extraction process.

[0016] In this device, the first nanofiltration membrane assembly is also connected to a pure water storage tank; the permeate outlet of the first nanofiltration membrane assembly is connected to an ethanol solution recovery tank. This solution washes the retentate after the primary nanofiltration process to remove any ethanol remaining in the retentate, and then recovers the permeate from the nanofiltration process into the ethanol solution recovery tank, thus reusing resources and reducing energy consumption for chlorogenic acid extraction.

[0017] In this device, the stevia phase outlet of the simulated moving bed chromatography separation system is connected to a macroporous adsorption resin column, a reverse osmosis system, an anion exchange resin column, a cation exchange resin column, a third nanofiltration membrane assembly, a drying tank, and a stevia storage tank. The macroporous adsorption resin column is also connected to an analytical reagent storage tank, an acid storage tank, and an alkaline storage tank. This setup processes the stevia phase and recovers stevia, thereby increasing the utilization rate of the stevia extract. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0019] Figure 1 This is a schematic structural diagram of Example 1 of the present utility model;

[0020] In the figure, 1. extract storage tank; 2. first nanofiltration membrane assembly; 3. concentrate storage tank; 4. simulated moving bed chromatography separation system; 5. chlorogenic acid phase buffer tank; 6. second nanofiltration membrane assembly; 7. hot concentration tank; 8. spray dryer; 9. chlorogenic acid storage tank; 10. first pH adjuster storage tank; 11. second pH adjuster storage tank; 12. pure water storage tank; 13. ethanol solution recovery tank; 14. macroporous adsorption resin column; 15. reverse osmosis system; 16. anion exchange resin column; 17. cation exchange resin column; 18. third nanofiltration membrane assembly; 19. drying tank; 20. stevia storage tank; 21. acid storage tank; 22. alkali storage tank; 23. analytical agent storage tank. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0022] Example 1

[0023] like Figure 1 As shown, a chlorogenic acid extraction device includes an extract storage tank 1, a first nanofiltration membrane assembly 2, a concentrated liquid storage tank 3, a simulated moving bed chromatography separation system 4, a chlorogenic acid phase buffer tank 5, a second nanofiltration membrane assembly 6, a hot concentration tank 7, a spray dryer 8, and a chlorogenic acid storage tank 9; the concentrated liquid storage tank 3 and the chlorogenic acid phase buffer tank 5 are respectively connected to a first pH adjuster storage tank 10 and a second pH adjuster storage tank 11.

[0024] The extract in the extract storage tank 1 enters the first nanofiltration membrane module 2 for treatment, and the retentate enters the simulated moving bed chromatography separation system 4 for separation. The chlorogenic acid phase and the stevia phase in the extract are separated by utilizing the different binding strengths between the chlorogenic acid phase and the stevia phase. The chlorogenic acid phase enters the chlorogenic acid phase buffer tank 5, then passes through the second nanofiltration membrane module 6 for impurity removal, is concentrated in the thermal concentration tank 7, and finally dried in the spray dryer 8 before entering the chlorogenic acid storage tank 9 to obtain the chlorogenic acid product. This device has a simple structure and simplifies the chlorogenic acid extraction process.

[0025] Furthermore, in this embodiment, the first nanofiltration membrane assembly 2 is connected to a pure water storage tank 12. After the extract is concentrated using the first nanofiltration membrane assembly 2, pure water is added to the retentate for secondary concentration. The secondary concentrated retentate then enters the simulated moving bed chromatography separation system 4 for processing. This solution effectively flushes away residual ethanol in the retentate.

[0026] Furthermore, in this embodiment, the permeate outlet of the first nanofiltration membrane assembly 2 is connected to the ethanol solution recovery tank 13. The permeate when the first nanofiltration membrane assembly 2 processes the extract is an ethanol solution, which enters the ethanol solution recovery tank 13 and can be reused for the extraction of stevia, which not only reduces the generation of wastewater, but also realizes the reuse of resources and reduces the energy consumption when extracting chlorogenic acid.

[0027] Furthermore, in this embodiment, the stevia phase outlet of the simulated moving bed chromatography separation system 4 is connected to the macroporous adsorption resin column 14, the reverse osmosis system 15, the anion exchange resin column 16, the cation exchange resin column 17, the third nanofiltration membrane assembly 18, the drying tank 19 and the stevia storage tank 20; the macroporous adsorption resin column 14 is also connected to the acid storage tank 21, the alkali storage tank 22 and the analytical agent storage tank 23.

[0028] Furthermore, the number of the macroporous adsorption resin columns 14 is at least two, and at least two macroporous adsorption resin columns 14 are arranged in series.

[0029] Furthermore, the mobile phase inlet of the simulated moving bed chromatography separation system 4 is connected to the pure water storage tank 12. This device uses pure water as the mobile phase. Under the action of pure water and the stationary phase in the simulated moving bed chromatography separation system 4, the chlorogenic acid phase and the stevioside phase are effectively separated, obtaining a high recovery rate of chlorogenic acid.

[0030] The above description of the disclosed embodiments will enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A chlorogenic acid extraction device, characterized in that: It includes an extract storage tank, a first nanofiltration membrane assembly, a concentrated liquid storage tank, a simulated moving bed chromatography separation system, a chlorogenic acid phase buffer tank, a second nanofiltration membrane assembly, a hot concentration tank, a spray dryer, and a chlorogenic acid storage tank; the concentrated liquid storage tank and the chlorogenic acid phase buffer tank are respectively connected to the first pH adjuster storage tank and the second pH adjuster storage tank.

2. The chlorogenic acid extraction device according to claim 1, characterized in that: The first nanofiltration membrane assembly is also connected to a pure water storage tank.

3. The chlorogenic acid extraction device according to claim 1, characterized in that: The permeate outlet of the first nanofiltration membrane assembly is connected to the ethanol solution recovery tank.

4. The chlorogenic acid extraction device according to claim 1, characterized in that: The stevioside phase outlet of the simulated moving bed chromatographic separation system is connected to a macroporous adsorption resin column, a reverse osmosis system, an anion exchange resin column, a cation exchange resin column, a third nanofiltration membrane component, a drying tank and a stevioside storage tank.

5. The chlorogenic acid extraction device according to claim 4, characterized in that: The macroporous adsorption resin column is also connected to an acid solution storage tank and an alkali solution storage tank.

6. The device for extracting chlorogenic acid according to claim 4, characterized in that: The number of the macroporous adsorption resin columns is at least two, and at least two macroporous adsorption resin columns are arranged in series.

7. The device for extracting chlorogenic acid according to claim 4, characterized in that: The macroporous adsorption resin column is also connected to a decomposing agent storage tank.

8. The device for extracting chlorogenic acid according to claim 2, characterized in that: The mobile phase inlet of the simulated moving bed chromatography separation system is communicated with the pure water storage tank.

Images