Oscillating device for cell separation

Abstract

The utility model relates to the technical field of cell separation, and discloses an oscillation device for cell separation, which comprises a box body serving as a device shell, an oscillation plate for driving cells to oscillate is arranged at the upper end in the box body, a sealing edge is fixedly connected to the outer side of the oscillation plate, a clamping assembly is arranged on the upper side of the oscillation plate, and the clamping assembly is fixedly connected with the box body. The clamping assembly is divided into an upper layer and a lower layer, the upper layer and the lower layer are connected through an adjusting assembly, the clamping assembly comprises a fixed clamping plate, sliding rails are fixedly connected to the left end and the right end of the fixed clamping plate, and movable clamping plates are slidably connected to the front end and the rear end of each sliding rail. The movable clamping plates on the front side and the rear side of the fixed clamping plate are close to the fixed clamping plate, a test tube containing cells can be clamped and fixed, operation is easy and convenient, the push rod moves, the lifting plate can be pushed to ascend, the fixed clamping plate, the movable clamping plates and the like are pushed out of the box body, the test tube can be clamped and fixed conveniently, and meanwhile equipment can be cleaned conveniently.

Description

Technical Field

[0001] The utility model relates to the technical field of cell separation, in particular to an oscillating device for cell separation. Background Art

[0002] The cell separation oscillating device is a device used to separate and purify cells, and is widely used in biomedicine, cell engineering, biotechnology and other fields. Its main working principle is to separate cells from a mixed liquid by using physical differences between cells (such as size, density and surface characteristics) through oscillation and fluid dynamics.

[0003] After searching, a stem cell separation device with announcement number CN212770675U includes a base, the top outer wall of the base is provided with an L-shaped support column, and the bottom outer wall of the support column is hinged with a connecting rod, the end of the connecting rod away from the support column is provided with a clamping mechanism, the outer wall of one side of the support column is fixed with a motor by screws, and the output shaft of the motor is sleeved with a turntable, the outer wall of the turntable is hinged with a hinged rod, and the end of the hinged rod away from the turntable is hinged with a separation tube, and the outer walls of the separation tube are provided with cutting blocks distributed in an equidistant ring. The two clamping rings of the utility model can clamp and fix the separation tube, control the motor to drive the turntable to rotate, and when the turntable rotates, the separation tube swings back and forth under the action of the hinged rod to oscillate. During the oscillation, the cutting block can also cut the stem cells, thereby completing the separation of the stem cells. The stem cells can be fully oscillated, and the cell separation effect is better.

[0004] Based on the above patent, the separation tube can be clamped and fixed by two clamping rings, and the turntable rotates, and the separation tube swings back and forth under the action of the hinged rod to oscillate. However, the structure used for oscillation is connected to the separation tube by a hinge, which is equivalent to a fixed structure. Such a structure makes it inconvenient to put the cell sample into and take out the separation tube, and the oscillation is achieved by swinging left and right, and the oscillation effect is limited. Utility Model Content

[0005] The purpose of the utility model is to solve the shortcomings of the prior art and to propose an oscillating device for cell separation, which can fix the test tube conveniently and quickly and is applicable to test tubes of different heights and thicknesses.

[0006] To achieve the above objectives, the present invention provides the following technical solutions:

[0007] A shaking device for cell separation, comprising:

[0008] A box body as the outer shell of the device, an oscillation plate for driving the cell oscillation is provided at the upper end of the interior of the box body, an edge seal is fixedly connected to the outer side of the oscillation plate, a clamping assembly is provided on the upper side of the oscillation plate, the clamping assembly is divided into an upper and lower layers, which are connected by an adjustment assembly, the clamping assembly includes a fixed clamping plate, the left and right ends of the fixed clamping plate are fixedly connected to the slide rail, the front and rear ends of the slide rail are slidably connected to the movable clamping plate, and the upper sides of the left and right ends of the movable clamping plate are threaded with fasteners;

[0009] A lifting plate, the outer wall of the lifting plate is tightly fitted with the inner wall of the box, a plurality of fixing columns are fixedly connected to the upper side of the lifting plate, a sphere is provided inside the upper end of the fixing column, the outer wall of the sphere is tightly fitted with the lower side of the oscillation plate, an installation box is fixedly connected to the middle part of the lower side of the lifting plate, an oscillation component is provided inside the installation box, and a lifting component is provided on the outside of the lower side of the lifting plate.

[0010] Furthermore, the adjustment component includes a telescopic rod fixedly connected to the left and right ends of the lower fixed splint, the bottom of the telescopic rod is fixedly connected to the left and right ends of the upper side of the oscillation plate, and the top of the telescopic end of the telescopic rod is respectively fixedly connected to the left and right ends of the upper fixed splint.

[0011] Furthermore, the adjustment assembly also includes an internal threaded column fixedly connected to the middle part of the lower fixed clamping plate, the bottom of the internal threaded column is fixedly connected to the middle part of the upper side of the oscillation plate, the upper end of the internal threaded column is internally threadedly connected to an external threaded column, the upper end of the external threaded column is rotatably connected to the middle part of the upper fixed clamping plate, and the top of the external threaded column is fixedly connected to a turntable.

[0012] Furthermore, a clamping slot is provided on one side opposite to the fixed clamping plate and the movable clamping plate, and a soft pad is fixedly connected to the inner side of the clamping slot.

[0013] Furthermore, sponge pads are provided at both front and rear ends of the upper side of the oscillation plate, and limit pins are passed through both left and right ends of the sponge pad, and the bottoms of the limit pins are respectively fixedly connected to the upper side of the oscillation plate.

[0014] Furthermore, the oscillation component includes a motor fixedly connected inside the mounting box, the driving end of the motor is fixedly connected to an eccentric wheel, the upper side of the eccentric wheel is fixedly connected to an eccentric shaft, and the top of the eccentric shaft is rotatably connected to the lower side of the oscillation plate.

[0015] Furthermore, the lifting assembly includes a plurality of fixed blocks fixedly connected to the bottom of the inner wall of the box, the middle part of the fixed block is fixedly connected to an electric push rod, the driving end of the electric push rod is fixedly connected to a movable plate, the lower end of the movable plate is slidably connected to the bottom of the inner wall of the box, the upper end of the movable plate is rotatably connected to a push rod, and the upper end of the push rod is rotatably connected to the lower side of the lifting plate.

[0016] Furthermore, a cover plate is rotatably connected to the top of the box body, and a transparent observation window is provided in the middle of the cover plate.

[0017] The utility model has the following beneficial effects:

[0018] 1. In the utility model, the test tubes containing cells can be clamped and fixed by moving the movable clamps on the front and rear sides of the fixed clamp closer to the fixed clamp. The operation is simple and convenient, and test tubes of different thicknesses can be clamped and fixed. At the same time, the distance between the upper fixed clamp and the lower fixed clamp can be adjusted, so that test tubes of different heights can be clamped and fixed.

[0019] 2. In the present invention, by retracting the driving end of the electric push rod, the push rod can be driven to move, thereby pushing the lifting plate up and pushing the fixed splint, movable splint, etc. out of the box, making it convenient to clamp and fix the test tube and convenient to clean the equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is an overall schematic diagram of an oscillating device for cell separation proposed in the present invention;

[0021] Figure 2 This is a schematic diagram of an explosion of an oscillating device for cell separation proposed in the present invention;

[0022] Figure 3 This is a schematic diagram of a fixed clamping plate of an oscillating device for cell separation proposed by the present invention;

[0023] Figure 4 This is a schematic diagram of an externally threaded column of an oscillating device for cell separation proposed in the present invention;

[0024] Figure 5 This is a schematic diagram of a motor of an oscillating device for cell separation proposed in the present invention;

[0025] Figure 6 This is a schematic diagram of an electric push rod of an oscillating device for cell separation proposed by the present invention.

[0026] Legend:

[0027] 1. Box body; 2. Oscillation plate; 3. Edge banding; 4. Fixed splint; 5. Slide rail; 6. Moving splint; 7. Fastener; 8. Cushion; 9. Lifting plate; 10. Fixed column; 11. Sphere; 12. Mounting box; 13. Telescopic rod; 14. Internally threaded column; 15. Externally threaded column; 16. Turntable; 17. Limit pin; 18. Sponge pad; 19. Motor; 20. Eccentric wheel; 21. Eccentric shaft; 22. Fixed block; 23. Electric push rod; 24. Movable plate; 25. Push rod; 26. Cover plate. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0029] Reference Figure 1 、 Figure 3 and Figure 4 The utility model provides an embodiment of an oscillation device for cell separation, comprising: a box body 1 as the outer shell of the device, a cover plate 26 is rotatably connected to the top of the box body 1, a transparent observation window is provided in the middle of the cover plate 26, an oscillation plate 2 for driving the cell oscillation is provided at the upper end of the interior of the box body 1, an edge seal 3 is fixedly connected to the outer side of the oscillation plate 2, two fixed splints 4 are provided on the upper side of the oscillation plate 2, the left and right ends of the fixed splint 4 are fixedly connected to slide rails 5, the front and rear ends of the slide rails 5 are slidably connected to movable splints 6, the upper sides of the left and right ends of the movable splint 6 are threadedly connected with fasteners 7, a slot is provided on the opposite side of the fixed splint 4 and the movable splint 6, a soft pad 8 is fixedly connected to the inside of the slot, and the left and right ends of the lower fixed splint 4 are fixed A telescopic rod 13 is fixedly connected, the bottom of the telescopic rod 13 is fixedly connected to the left and right ends of the upper side of the oscillation plate 2, the top of the telescopic end of the telescopic rod 13 is respectively fixedly connected to the left and right ends of the upper fixed splint 4, and the middle part of the lower fixed splint 4 is fixedly connected to the internal threaded column 14, the bottom of the internal threaded column 14 is fixedly connected to the middle part of the upper side of the oscillation plate 2, the upper end of the internal threaded column 14 is internally threaded with an external threaded column 15, the upper end of the external threaded column 15 is rotatably connected to the middle part of the upper fixed splint 4, and the top of the external threaded column 15 is fixedly connected to a turntable 16. Sponge pads 18 are provided at the front and rear ends of the upper side of the oscillation plate 2, and limit pins 17 are passed through the left and right ends of the sponge pad 18, and the bottoms of the limit pins 17 are respectively fixedly connected to the upper side of the oscillation plate 2.

[0030] The external threaded column 15 is driven to rotate by the turntable 16, and the rotating external threaded column 15 can be gradually retracted into the interior of the internal threaded column 14, thereby driving the upper fixed clamping plate 4 to descend, adjusting the distance between the two fixed clamping plates 4, and adjusting the height of the upper fixed clamping plate 4, so that test tubes of different heights can be clamped and fixed, and the test tubes containing cells are placed between the fixed clamping plate 4 and the movable clamping plate 6, so that the movable clamping plate 6 is close to the fixed clamping plate 4, so as to fix the test tube, and the rotating fastener 7 can fix the movable clamping plate 6 after moving. The overall operation is simple and convenient, and the efficiency is high. The provided sponge pad 18 can prevent the test tube from directly contacting the oscillation plate 2, which may cause damage to the test tube.

[0031] Reference Figure 2 、 Figure 5 and Figure 6 The outer wall of the lifting plate 9 is tightly fitted with the inner wall of the box body 1, and the upper side of the lifting plate 9 is fixedly connected with a plurality of fixing columns 10. A sphere 11 is provided inside the upper end of the fixing column 10, and the outer wall of the sphere 11 is tightly fitted with the lower side of the oscillation plate 2; the lower middle part of the lifting plate 9 is fixedly connected with a mounting box 12, and the interior of the mounting box 12 is fixedly connected with a motor 19, and the driving end of the motor 19 is fixedly connected with an eccentric wheel 20, and the upper side of the eccentric wheel 20 is fixedly connected with an eccentric shaft 21, and the top of the eccentric shaft 21 is rotatably connected to the lower side of the oscillation plate 2; the bottom of the inner wall of the box body 1 is fixedly connected with a plurality of fixing blocks 22, and the middle part of the fixing block 22 is fixedly connected with an electric push rod 23, and the driving end of the electric push rod 23 is fixedly connected with a movable plate 24, and the lower end of the movable plate 24 is slidably connected to the bottom of the inner wall of the box body 1, and the upper end of the movable plate 24 is rotatably connected with a push rod 25, and the upper end of the push rod 25 is rotatably connected to the lower side of the lifting plate 9.

[0032] The motor 19 set when started can drive the eccentric wheel 20 and the eccentric shaft 21 to rotate, and the eccentric shaft 21 drives the oscillation plate 2 to shake, thereby shaking the cells. The set sphere 11 can rotate on the top of the fixed column 10, and the rotating sphere 11 contacts the oscillation plate 2 to support the oscillation plate 2, which can reduce the friction resistance of the shaking of the oscillation plate 2. The driving end of the electric push rod 23 is retracted, which can drive the push rod 25 to move, thereby pushing the lifting plate 9 to rise, and pushing the fixed splint 4, the movable splint 6, etc. out of the box 1, which is convenient for clamping and fixing the test tube, and at the same time convenient for cleaning the equipment.

[0033] Working principle: Start the electric push rod 23 to drive the movable plate 24 to slide, thereby driving the pushing rod 25 to move, and push the lifting plate 9 to rise through the pushing rod 25, and bring the fixed splint 4 and the movable splint 6 out of the interior of the box 1, and place the test tube containing cells in the slot set between the fixed splint 4 and the movable splint 6, so that the movable splint 6 is close to the fixed splint 4 to clamp the test tube in the middle, and fix the movable splint 6 by rotating the fastener 7, and drive the external threaded column 15 to rotate through the turntable 16. The external threaded column 15 cooperates with the internal threaded column 14 to drive the upper fixed splint 4 to descend, and adjust the height of the upper fixed splint 4 to facilitate the fixation of test tubes of different heights. Then, the lifting plate 9 is lowered to put the test tube into the interior of the box 1, and the motor 19 is started to drive the eccentric wheel 20 and the eccentric shaft 21 to rotate, thereby driving the oscillation plate 2 to shake, and oscillating the cells.

[0034] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A shaking device for cell separation, characterized in that: include: A box body (1) serving as the outer shell of the device, wherein an oscillation plate (2) for driving cell oscillation is provided at the upper end of the inner portion of the box body (1), an edge seal (3) is fixedly connected to the outer side of the oscillation plate (2), a clamping assembly is provided on the upper side of the oscillation plate (2), the clamping assembly is divided into an upper and lower layer, which are connected by an adjustment assembly, the clamping assembly includes a fixed clamping plate (4), both left and right ends of the fixed clamping plate (4) are fixedly connected to a slide rail (5), both front and rear ends of the slide rail (5) are slidably connected to a movable clamping plate (6), and both left and right upper sides of the movable clamping plate (6) are threadedly connected to fasteners (7); A lifting plate (9), the outer wall of the lifting plate (9) is tightly fitted with the inner wall of the box body (1), a plurality of fixing columns (10) are fixedly connected to the upper side of the lifting plate (9), a sphere (11) is provided inside the upper end of the fixing column (10), the outer wall of the sphere (11) is tightly fitted with the lower side of the oscillation plate (2), a mounting box (12) is fixedly connected to the middle part of the lower side of the lifting plate (9), an oscillation component is provided inside the mounting box (12), and a lifting component is provided outside the lower side of the lifting plate (9).

2. The oscillating device for cell separation according to claim 1, characterized in that: The adjustment assembly comprises a telescopic rod (13) fixedly connected to the left and right ends of the lower fixed clamping plate (4), the bottom of the telescopic rod (13) is fixedly connected to the left and right ends of the upper side of the oscillation plate (2), and the top of the telescopic end of the telescopic rod (13) is fixedly connected to the left and right ends of the upper fixed clamping plate (4).

3. The oscillating device for cell separation according to claim 1, characterized in that: The adjustment assembly further comprises an internal threaded column (14) fixedly connected to the middle of the lower fixed clamping plate (4), the bottom of the internal threaded column (14) is fixedly connected to the middle of the upper side of the oscillation plate (2), the upper end of the internal threaded column (14) is internally threadedly connected to an external threaded column (15), the upper end of the external threaded column (15) is rotatably connected to the middle of the upper fixed clamping plate (4), and the top of the external threaded column (15) is fixedly connected to a turntable (16).

4. The oscillating device for cell separation according to claim 1, characterized in that: A clamping slot is provided on the opposite side of the fixed clamping plate (4) and the movable clamping plate (6), and a soft pad (8) is fixedly connected to the inner side of the clamping slot.

5. The oscillating device for cell separation according to claim 1, characterized in that: Sponge pads (18) are provided at both the front and rear ends of the upper side of the oscillation plate (2), and limit pins (17) are passed through both the left and right ends of the sponge pad (18), and the bottoms of the limit pins (17) are fixedly connected to the upper side of the oscillation plate (2).

6. The oscillating device for cell separation according to claim 1, characterized in that: The oscillation assembly comprises a motor (19) fixedly connected to the interior of the mounting box (12), a driving end of the motor (19) fixedly connected to an eccentric wheel (20), an upper side of the eccentric wheel (20) fixedly connected to an eccentric shaft (21), and a top of the eccentric shaft (21) rotatably connected to the lower side of the oscillation plate (2).

7. The oscillating device for cell separation according to claim 1, characterized in that: The lifting assembly comprises a plurality of fixed blocks (22) fixedly connected to the bottom of the inner wall of the box body (1), the middle of the fixed block (22) is fixedly connected to an electric push rod (23), the driving end of the electric push rod (23) is fixedly connected to a movable plate (24), the lower end of the movable plate (24) is slidably connected to the bottom of the inner wall of the box body (1), the upper end of the movable plate (24) is rotatably connected to a push rod (25), and the upper end of the push rod (25) is rotatably connected to the lower side of the lifting plate (9).

8. The oscillating device for cell separation according to claim 1, characterized in that: The top of the box body (1) is rotatably connected to a cover plate (26), and a transparent observation window is provided in the middle of the cover plate (26).

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