282 results about "Cell contact" patented technology

Provided are electrokinetically-altered fluids (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating cystic fibrosis or a symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered fluids optionally in combination with other therapeutic agents (e.g., antibiotics, albuterol, budesonide, etc.). Particular embodiments comprise use and/or synergy with tobramycin for treating bacterial infection, and use and/or synergy with a bronchiodilator. In certain aspects, the methods comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins (like, membrane receptors, including but not limited to G protein coupled receptors, and intercellular junctions).

A support grid for a nuclear fuel assembly, the fuel rod assembly having a generally cylindrical fuel rod with a diameter, wherein the support grid includes a frame assembly having a plurality of generally uniform cells, each the cell having at least one wall and a width and at least one generally cylindrical tubular member having a cell contact portion with a greater diameter and at least one helical fuel rod contact portion with a lesser diameter, the cell contact portion and the fuel rod contact portion joined by a transition portion, the greater diameter being generally equivalent to the cell width, and the lesser diameter being generally equivalent to the fuel rod diameter such that a fuel rod disposed in the tubular member would engage the inner diameter. Wherein the least one tubular member disposed in one cell of the plurality of generally square cells so that the cell contact portion engages the at least one cell sidewall.

The present invention is primarily directed to improvements to cost-effective systems for concentrating and using solar energy. The present invention co-optimizes the frame and the primary mirrors and secondary concentrator for a cost-effective very high concentration quasi-parabolic dish system that uses no moulded optics for the primary concentration, and also optimizes fabrication jigs for the main components of that design. The present invention also optimizes cell contacts and provides cost effective receiver cooling for dense receiver arrays for very high concentration photovoltaic systems. The present invention also includes a semi-dense receiver array that can provide a higher acceptance angle than a dense receiver array, and finally includes mutual-shading impact minimization methods and apparatus compatible with very high concentration photovoltaic systems.

A method is disclosed for forming a memory device having buried access lines (e.g., wordlines) and buried data/sense lines (e.g., digitlines) disposed below vertical cell contacts. The buried wordlines may be formed trenches in a substrate extending in a first direction, and the buried digitlines may be formed from trenches in a substrate extending in a second direction perpendicular to the first direction. The buried digitlines may be coupled to a silicon sidewall by a digitline contact disposed between the digitlines and the silicon substrate.

The present invention provides compositions including a cell contacting surface or film comprising nanotopography of nanofibers, nanotubes, nanochannels, microchannels or microwells, which are capable of enhancing or promoting cell differentiation or cell viability. The compositions are useful as medical implants, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants. The present invention also provides methods of treating a patient in need of such an implant.

The present invention relates to a method of culturing peripheral lymphoid organ cells on a three-dimensional scaffolding which is covered or surrounded with culture medium, under conditions effective to generate and maintain mature and functional lymphoid cells, where the three-dimensional scaffolding allows cells in the culture medium to have cell to cell contact in three dimensions. The present invention also provides methods of screening for vaccine candidates for efficacy in eliciting an immune response, identifying genes or proteins which are related to peripheral lymphoid organ cell formation or function, screening for drugs effecting peripheral lymphoid organ cell maturation, treating a patient for a disease condition using antigen-specific lymphoid cells, and effecting gene expression of peripheral lymphoid organ cells.

A flat, flexible electrochemical cell is provided. The within invention describes various aspects of the flat, flexible electrochemical cell. A printed anode is provided that obviates the need for a discrete anode current collector, thereby reducing the size of the battery. An advantageous electrolyte is provided that enables the use of a metallic cathode current collector, thereby improving the performance of the battery. Printable gelled electrolytes and separators are provided, enabling the construction of both co-facial and co-planar batteries. Cell contacts are provided that reduce the potential for electrolyte creepage in the flat, flexible electrochemical cells of the within invention.

The bipolar electrochemical battery of the invention comprises:

• • a stack of at least two electrochemical cells electrically arranged in series with the positive face of each cell contacting the negative face of an adjacent cell, wherein each of the cells comprises
  • (a) a negative electrode;
  • (b) a positive electrode;
  • (c) a separator between the electrodes, wherein the separator includes an electrolyte;
  • (d) a first electrically conductive lamination comprising a first inner metal layer and a first polymeric outer layer, said first polymeric outer layer having at least one perforation therein to expose the first inner metal layer, said first electrically conductive lamination being in electrical contact with the outer face of the negative electrode; and
  • (e) a second electrically conductive lamination comprising a second inner metal layer and a second polymeric outer layer, said second polymeric outer layer having at least one perforation therein to expose the second inner metal layer, said second electrically conductive lamination being in electrical contact with the outer face of the positive electrode; wherein the first and second laminations are sealed peripherally to each other to form an enclosure including the electrodes, the separator and the electrolyte.

We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50 μm and 400 μm, such as about 200 μm. It may have a cross sectional dimension of between 20 μm and 30 μm. The particle may comprise a substantially compact or spherical shaped particle having a size of between about 20 μm and about 120 μm, for example about 65 μm. We also disclose a method of propagating primate or human stem cells, the method comprising: providing first and second primate or human stem cells attached to first and second respective particles, allowing the first primate or human stem cell to contact the second primate or human stem cell to form an aggregate of cells and culturing the aggregate to propagate the primate or human stem cells for at least one passage. A method of propagating human embryonic stem cells (hESCs) in long term suspension culture using microcarriers coated in Matrigel or hyaluronic acid is also disclosed. We also disclose a method for differentiating stem cells.

A microbial fuel cell device for aquatic plant electrodes in constructed wetlands, which belongs to the field of environmental protection and new energy. It includes a cathode tank and an anode tank. The special feature is that the cathode tank and the anode tank are separated by a separator, and the separator has a The plate shape of the through hole; the catholyte and the cathode electrode are arranged in the cathode tank, the anolyte and the anode electrode are arranged in the anode tank, and the anode electrode, the external resistance and the cathode electrode are connected by wires in sequence; the cathode tank and the upper part of the anode tank are connected with the Higher aquatic plants are respectively planted at the air contact positions. In the present invention, the planting cost of higher aquatic plants is very low, and the whole device does not need to use expensive selective permeable membranes and traditional cathode electrode materials loaded with precious metals such as platinum and gold, which greatly reduces the manufacturing cost; the device is applied When used in pollutant purification work such as sewage treatment, it has a long operating cycle, simple maintenance, strong decontamination ability, good pollutant degradation effect, and fully utilizes solar energy to generate high power.

The main objects of the present invention, which relates to regenerative medical treatments, are to enable (i) storage and conveyance of harvested or cultured cells without contamination occuring (ii) simple injection of the cells into a living body. To achieve these objects, cells harvested from a living body, or cells obtained by culturing harvested cells, are stored in a syringe-type storage vessel and subsequently transplanted into a living body. It is preferable that at least a part of the storage vessel inner wall in contact with the cells is formed from a cell non-adhesive material. Besides enabling cells in the vessel to take in the oxygen they require to survive, the present invention also enables cells quick and easy transplantation of cells into a living body without a cell detachment process, because cells are prevented from adhering to the inside of the vessel. Further, it is preferable that a stored tissue regeneration composition contains cell culture microcarriers floating in a fluidity medium, and that the cell culture microcarriers are composed of a bioabsorbable material and have cells adhering to their surfaces. Using this kind of tissue regeneration composition, a regenerative treatment can be carried out satisfactorily by simply and quickly transplanting cells from the syringe-type cell storage vessel into a living body without intricate scaffold-related procedures being required.

Viable differentiating cells from in vitro cultures of stem cells are selected for by partial dissociation to provide cell aggregates. Aggregates comprising cells of interest are selected for phenotypic features using methods that substantially maintain the cell to cell contacts in the aggregate.

A touch screen panel including: a transparent substrate that incorporate a display region and a non-display region; first sensing patterns that are arranged in a first direction and include first sensing cells and first connection parts; second sensing patterns that are arranged in a second direction and include second sensing cells and second connection parts; an insulating layer that is formed on each of the second connection parts in an island shape; the second sensing cells contact the ends of exposed second connection parts; a plurality of first sensing cells that are arranged on the display region in the first direction intersecting with the second direction; connection parts that connect the adjacent first sensing cells to each other; and metal patterns that are formed in the non-display region and are connected to each of the sensing cells disposed at the ends of the display region.

The present invention relates to methods for laser surgery and growth factor stimulation for ultra-precision surgery with healing. The method is achieved by cutting biological tissue using an ultrafast laser, which produces laser pulses less than 10 picosecond in duration, to induce a cold ablation process in order to avoid the formation of carbonaceous or other materials that cannot be removed efficiently or completely from the wounded area through natural healing mechanisms. By use of femtosecond lasers, a negligible amount of debris is generated and an outer layer of intact but non viable cells are created principally through shock wave induce damage and ionizing radiation effects induced by multiphoton absorption of ultrashort laser pulses. The normal healing process is blocked by this outer layer of cells as all cell contacts are still intact. Therefore the healing process must be stimulated. The healing may be triggered or accelerated, or both, by application of growth factor molecules and/or signal proteins to the effectively undamaged cells causing the damaged cells to be replaced and the wound to close. The combination of very precise laser cutting used in combination with growth factors is the key to this unique tool.

A cell contacting system for an electro-chemical device includes a plurality of electro-chemical cells and a current line system, wherein the cell contacting system includes a signal line system having signal lines for connecting a respective signal source to a signal line termination or to a monitoring device of the cell contacting system and a carrier element which carries the signal line system. The cell contacting system further includes at least one signal-line-system-side positioning element which is fixed to a signal line of the signal line system and at least one carrier-element-side positioning element which is fixed at least temporarily to the carrier element, wherein the signal-line-system-side positioning element is connected to the carrier-element-side positioning element at least temporarily in such a way that the signal-line-system-side positioning element is positioned in a desired position relative to a cell connector or a current termination of the current line system.

A semiconductor memory device includes a semiconductor substrate having active areas and a trench isolation region between the active areas. The active areas extend along a first direction. Buried word lines extend along a second direction in the semiconductor substrate. Two of the buried word lines intersect with each of the active areas, separating each of the active areas into a digit line contact area and two cell contact areas. The second direction is not perpendicular to the first direction. A digit line contact is disposed on the digit line contact area. A storage node contact is disposed on each of the two cell contact areas. The digit line contact and the storage node contact are coplanar. At least one digit line extends along a third direction over a main surface of the semiconductor substrate. The at least one digit line is in direct contact with the digit line contact.

A hydrogen generator includes at least two electrolytic cells, each comprising a membrane electrode assembly incorporating a solid polymer electrolyte. The membrane electrode of a first cell is exposed to water and the hydrogen produced in this cell contacts the cathode surfaces of the successive electrolytic cells, wherein any water entrained in or carried over with the hydrogen produced in the first cell is the only significant feedstock for the successive electrolytic cells.

In some embodiments, the first and second cells share a common chamber enclosing the respective electrodes. Hydrogen generated by the first cell diffuses into an expanded polytetrafluoroethylene tube adjacent to the cathode. The tube discharges into a space abutting the cathode of the second cell.