Coaxial reaction disc and chemiluminescence immunoassay analyzer

Abstract

The utility model provides a coaxial reaction disc and a chemiluminescence immunity analyzer. The coaxial reaction disc comprises a mounting seat, a dispatching mechanism and an incubation mechanism, wherein the mounting seat comprises a body and a rotating shaft, and the rotating shaft is fixed on the body; the dispatching mechanism comprises a first driving mechanism and a dispatching disc, the dispatching disc is rotationally arranged on the body and can be driven by the first driving mechanism to rotate around the axis of the rotating shaft, reaction cup positions are further arranged in the circumferential direction of the dispatching disc, and the reaction cup positions are used for containing reaction cups; the incubation mechanism comprises a second driving mechanism and an incubation disc, the incubation disc is rotationally arranged on the body and can rotate around the axis of the rotating shaft under the driving of the second driving mechanism, an incubation position is arranged on the incubation disc, and the incubation position is used for placing the reaction cup. The coaxial reaction disc disclosed by the utility model is simple in structure, and the operation related to a shifting mechanism is less, so that the dispatching efficiency can be improved.

Description

Technical Field

[0001] The utility model relates to the field of biological detection, in particular to a chemiluminescence immunoassay analyzer. Background Art

[0002] The traditional chemiluminescence immunoassay reaction system mainly relies on a simple reaction disk for scheduling, which has poor flexibility and low efficiency. Since the reaction disk needs to realize the incubation function, in some cases it also takes into account the light measurement, there are too many action nodes to realize it, resulting in poor flexibility, low scheduling efficiency, and complex logic. The reaction disk in the existing patent CN 209542458 U is a reaction system that takes into account the light measurement function. The scheduling logic of the reaction cup on the reaction disk is very complex and inefficient. The existing patent CN216816700U proposes a dual reaction disk system. Although it improves the scheduling flexibility, the inner and outer disks share a common heating source and cannot achieve the "direct heating" effect. The incubation efficiency is low. In addition, the inner and outer disks are two parts, and the temperature consistency becomes poor. At the same time, the two disks also need to realize the incubation action, which will reduce the scheduling efficiency.

[0003] Conventional technology generally requires a robotic arm to place the cuvette into the incubation tray for incubation and heating. While conventional robotic grippers with three or more axes can handle both placement and removal of cuvettes from the incubation tray, these grippers require a significant amount of space to maneuver, and their efficiency decreases with increasing control dimensions. This results in a three-axis gripper being far less efficient than a two-axis gripper, and their cost is significantly higher. Utility Model Content

[0004] In view of the deficiencies of the prior art, the present invention provides a coaxial reaction disk and a chemiluminescence immunoassay analyzer, so as to simplify the structure of the chemiluminescence immunoassay analyzer and improve the scheduling efficiency.

[0005] To this end, according to a first aspect, an embodiment provides a coaxial reaction disk, comprising:

[0006] A main body, wherein a rotating shaft is provided on the main body;

[0007] a scheduling mechanism comprising a first drive mechanism and a scheduling disk, wherein the scheduling disk is rotatably mounted on the body and is capable of rotating around the axis of the rotating shaft under the drive of the first drive mechanism, and a cuvette position is further provided on the circumference of the scheduling disk, wherein the cuvette position is used to place a cuvette; and

[0008] The incubation mechanism includes a second driving mechanism and an incubation tray. The incubation tray is rotatably arranged on the body and can rotate around the axis of the rotating shaft under the drive of the second driving mechanism. The incubation tray is provided with an incubation position for placing the reaction cup.

[0009] As a further optional solution of the coaxial reaction tray, the reaction cups are positioned around the edge of the incubation tray.

[0010] As a further optional solution of the coaxial reaction disk, the incubation mechanism is further provided with a heat preservation pot, and the heat preservation pot is located at the incubation position to keep the incubation position warm.

[0011] As a further optional solution of the coaxial reaction tray, the incubation mechanism is further provided with a heat-insulating cover, which covers the incubation tray and has a through hole corresponding to the incubation position, so that the reaction cup enters the incubation position through the through hole.

[0012] As a further optional solution of the coaxial reaction tray, the edge of the heat-insulating cover is provided with a notch, and the notch is used to locate the rotation position of the incubation mechanism.

[0013] As a further optional solution for the coaxial reaction tray, the first driving mechanism and / or the second driving mechanism comprises a motor and a transmission device, and the motor drives the scheduling tray and / or the incubation tray to rotate through the linkage of the transmission device.

[0014] As a further optional solution of the coaxial reaction disk, the transmission device is a transmission belt.

[0015] As a further optional solution of the coaxial reaction disk, the scheduling mechanism includes a first bearing, and the first bearing is arranged between the scheduling disk and the rotating shaft.

[0016] As a further optional solution of the coaxial reaction tray, the incubation mechanism includes a second bearing, and the second bearing is arranged between the incubation tray and the rotating shaft.

[0017] In a second aspect, the present invention further provides a chemiluminescent immunoassay instrument, which includes a shifting mechanism, a detection mechanism, and the coaxial reaction disk described in any one of the first aspects, wherein the shifting mechanism is used to transfer the reaction cup, and the detection mechanism is used to detect the reaction cup after incubation.

[0018] The implementation of the present invention will have the following beneficial effects:

[0019] According to the coaxial reaction disk in the above embodiment, the scheduling disk is driven to rotate by the first driving mechanism, and the reaction cup is moved to a designated position and then the reagent is added. Then, the scheduling disk is rotated again to the external shifting mechanism, and the shifting mechanism grabs the reaction cup and transports it to the incubation position on the incubation disk. After the incubation of the reaction cup is completed, the incubation disk is driven by the second driving mechanism to rotate until it reaches the corresponding external shifting mechanism. The shifting mechanism only needs to be able to drive the reaction cup to complete the up and down movement and the radial movement along the coaxial reaction disk. Therefore, the shifting mechanism only needs to use a two-axis mechanical claw to achieve the purpose of transporting the reaction cup. Moreover, the scheduling mechanism can not only be used for the corresponding shifting mechanism, but also can transfer the reaction cup to the detection position, or the reagent addition position, etc. The implementation of the coaxial reaction disk in the present utility model can achieve the purpose of improving the scheduling efficiency of the reaction cup.

[0020] According to the chemiluminescent immunoassay analyzer of the above embodiment, the shift mechanism primarily moves the cuvette from the scheduling mechanism to the incubation mechanism, while the detection mechanism can be used to detect the cuvette after incubation. The chemiluminescent immunoassay analyzer of the present invention, due to its coaxial reaction disk of the first aspect, has a simpler and more compact structure and improves the efficiency of cuvette scheduling. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0022] in:

[0023] Figure 1 The figure shows the overall structure of the coaxial reaction disk provided in accordance with an embodiment of the present invention;

[0024] Figure 2 A schematic diagram of the assembly of the mounting base and the scheduling mechanism provided according to an embodiment of the present utility model is shown;

[0025] Figure 3 A cross-sectional schematic diagram of a coaxial reaction disk provided according to an embodiment of the present utility model is shown.

[0026] Description of main component symbols:

[0027] Main body 110; rotating shaft 120; dispatching mechanism 20; first driving mechanism 210; dispatching plate 220; reaction cup 100; incubation mechanism 30; second driving mechanism 310; incubation plate 320; insulation pot 330; incubation position 340; insulation cover 350; through hole 3510; transmission belt 231; first bearing 240; second bearing 360. DETAILED DESCRIPTION

[0028] To facilitate understanding of the present invention, a more comprehensive description of the present invention will be provided below with reference to the accompanying drawings. The drawings illustrate preferred embodiments of the present invention. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and comprehensive understanding of the disclosure of the present invention.

[0029] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly attached to the other element or there may be an intermediate element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only.

[0030] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used herein in the specification of this invention are intended only to describe specific embodiments and are not intended to limit the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0031] In the embodiment of the present invention, a coaxial reaction disk and a chemiluminescence immunoassay are provided. Figure 1-Figure 3 The coaxial reaction tray includes a mounting base 10, a scheduling mechanism 20 and an incubation mechanism 30.

[0032] The body 110 is provided with a rotating shaft 120;

[0033] The mounting base 10 includes a body 110 and a rotating shaft 120 , wherein the rotating shaft 120 is fixed to the body 110 ;

[0034] The scheduling mechanism 20 includes a first drive mechanism 210 and a scheduling disk 220. The scheduling disk 220 is rotatably mounted on the body 110 and is rotatable about the axis of the rotating shaft 120 under the drive of the first drive mechanism 210. A cuvette position (not shown) is further provided on the circumference of the scheduling disk 220 for placing the cuvette 100.

[0035] The incubation mechanism 30 includes a second driving mechanism 310 and an incubation tray 320. The incubation tray 320 is rotatably arranged on the body 110 and can rotate around the axis of the rotating shaft 120 under the drive of the second driving mechanism 310. The incubation tray 320 is provided with an incubation position 340 for placing the reaction cup 100.

[0036] According to the coaxial reaction tray in the above embodiment, the dispatch tray 220 is driven by the first drive mechanism 210 to rotate, moving the cuvette 100 to a designated position for reagent addition. The dispatch tray 220 then rotates again to the external shift mechanism, which grabs the cuvette 100 and transfers it to the incubation position 340 on the incubation tray 320. After the cuvette 100 is incubated, the incubation tray 320 is driven by the second drive mechanism 310 to the corresponding external shift mechanism. The shift mechanism only needs to be able to drive the cuvette 100 to complete up and down movement and radial movement along the coaxial reaction tray. Therefore, the shift mechanism only needs to use a two-axis mechanical gripper to achieve the purpose of transporting the cuvette. Furthermore, the dispatch mechanism 20 can be used not only for the corresponding shift mechanism but also to transfer the cuvette 100 to the detection position, reagent addition position, and so on. The coaxial reaction tray of the present invention can achieve the goal of improving the efficiency of cuvette dispatching.

[0037] In some specific embodiments, the cuvette 100 surrounds the edge of the incubation tray 320 .

[0038] The reaction cup 100 surrounds the edge of the incubation tray 320 , so there is no obstruction or limitation when the shifting mechanism moves the reaction cup 100 , and the requirements for the shifting mechanism are relatively simple.

[0039] The primary function of the cuvette 100 is to house it. Its structure can be diverse, and any technical solution capable of housing and securing the cuvette 100 falls within the scope of protection of this application. For example, a groove can be provided on the reaction tray, into which the body of the cuvette 100 is placed. Alternatively, multiple placement holes can be provided on the reaction tray, with the diameter of the placement holes being larger than the diameter of the body of the cuvette 100 but smaller than the diameter of the lid of the cuvette 100. After the cuvette 100 is placed in the through hole 3510, it is suspended in the air.

[0040] Generally speaking, when the cuvette 100 is placed in the cuvette 100 and the incubation position 340, the cuvette 100 is kept on the same horizontal plane. This design allows the shift mechanism to only consider horizontal displacement during shifting, while the vertical displacement setting remains unchanged.

[0041] In some specific embodiments, please refer to Figure 1 and Figure 3The hatching mechanism 30 is further provided with a heat preservation pot 330 , which is located at the hatching position 340 to keep the hatching position 340 warm.

[0042] Typically, samples are pipetted into the cuvette 100, mixed evenly, and then allowed to combine with the reagents. This combination requires a constant temperature environment, and the thermal insulation pot 330 provides a stable temperature environment to facilitate the successful combination of the reagents and samples. This ultimately ensures consistent, fast, and accurate sample testing data.

[0043] The heat preservation pot 330 can generally generate heat by itself, and the temperature inside the heat preservation pot 330 can be controlled by cooperating with the temperature control unit to maintain a constant temperature for a certain period of time.

[0044] In some specific embodiments, the incubation mechanism 30 is further provided with an insulation cover 350 , which covers the incubation tray 320 and has a through hole 3510 corresponding to the incubation position 340 , so that the reaction cup 100 can enter the incubation position 340 through the through hole 3510 .

[0045] The main function of the heat preservation cover 350 is to prevent the heat in the heat preservation pot 330 from being dissipated. The heat preservation cover 350 can reduce the heat loss of the heat preservation pot 330, and the through hole 3510 can also facilitate the entry and exit of the reaction cup 100.

[0046] In some specific embodiments, a notch is provided on the edge of the heat-insulating cover 350 , and the notch is used to locate the rotation position of the incubation mechanism 30 .

[0047] The notches are generally arranged at equal intervals, allowing a person to observe the rotation position of the incubation tray 320. Alternatively, a light sensor can be used to sense the specific position of the incubation tray 320, thereby achieving accurate scheduling of the reaction cups 100.

[0048] It should be noted that there are generally multiple incubation positions 340 to facilitate simultaneous incubation of multiple groups of reaction cups 100 for batch testing. Therefore, it is necessary to accurately control the rotation position of the incubation tray 320 so that multiple groups of reaction cups 100 appear in the corresponding positions of the testing mechanism in sequence.

[0049] In some specific embodiments, the first driving mechanism 210 and / or the second driving mechanism 310 include a motor and a transmission device, and the motor drives the scheduling disk 220 and / or the hatching disk 320 to rotate through the linkage of the transmission device.

[0050] The first drive mechanism 210 and the second drive mechanism 310 can be implemented in a variety of ways, preferably using motors. The motors are typically fixed to the body 110, thereby achieving the coaxial integration of the reaction trays in the present invention. These motors are typically stepper motors, allowing for precise control of the rotational angles of the reaction tray and incubation tray 320.

[0051] In some specific embodiments, the transmission device is a transmission belt 231 .

[0052] One end of the transmission belt 231 can be connected to the motor, and the other end can be connected to the hatching tray 320 or the scheduling tray 220. Power is transmitted to the hatching tray 320 or the scheduling tray 220 by the transmission belt 231.

[0053] Of course, the transmission device can also be realized by a transmission chain or a transmission gear set.

[0054] In some specific embodiments, the scheduling mechanism 20 includes a first bearing 240 , which is disposed between the scheduling disk 220 and the rotating shaft 120 .

[0055] In some specific embodiments, the incubation mechanism 30 includes a second bearing 360 , which is disposed between the incubation tray 320 and the rotating shaft 120 .

[0056] The first bearing 240 and the second bearing 360 are generally sleeved on the rotating shaft 120, the first bearing 240 is fixedly connected to the scheduling plate 220, and the second bearing 360 is fixedly connected to the hatching plate 320. Generally speaking, the first bearing 240 and the second bearing 360 are stacked, but do not contact each other.

[0057] In the second aspect, the chemiluminescence immunoassay analyzer includes a shift mechanism (not shown in the figure), a detection mechanism (not shown in the figure) and any coaxial reaction disk of the first aspect. The shift mechanism (not shown in the figure) is used to transfer the reaction cup 100, and the detection mechanism is used to detect the reaction cup 100 after incubation.

[0058] According to the chemiluminescent immunoassay analyzer of the above embodiment, the shift mechanism primarily moves the cuvette 100 from the dispatch mechanism 20 to the incubation mechanism 30, while the detection mechanism can be used to detect the incubated cuvette 100. The chemiluminescent immunoassay analyzer of the present invention, due to its coaxial reaction disk of the first aspect, has a simpler and more compact structure and improves the dispatch efficiency of the cuvette 100.

[0059] The specific process of the chemiluminescence immunoassay in this utility model is:

[0060] 1. The incubation tray 320 and the scheduling tray 220 are located at the preset initial positions. At this time, the sampling device puts the sample into one of the reaction cups 100 and shakes it evenly.

[0061] 2. The dispatch tray 220 begins to rotate, causing the sample-loaded cuvette 100 to move to the shift mechanism. The shift mechanism then transfers the sample-loaded cuvette 100 to the incubation position 340 of the incubation tray 320, specifically to the through-hole 3510 of the thermal cover 350. Simultaneously, the sampling device places the sample into the next cuvette 100.

[0062] After a period of time, the incubation tray 320 is rotated to move the reaction cup 100 at the incubation position 340 to the detection mechanism, so that the reaction cup 100 can be detected.

[0063] It should be noted that the shift mechanism is typically a mechanical gripper, requiring at least a two-axis motion structure to facilitate placement and transfer of the cuvette 100. The detection mechanism is typically an optical detection mechanism, which typically requires the cooperation of the shift mechanism to remove the cuvette 100 from the thermal insulation pot 330. Multiple shift mechanisms are typically provided to accommodate different cuvette 100 transport requirements.

[0064] The transfer mechanism (not shown) is typically a multi-axis mechanical gripper, whose relative transfer speed is slower than that of a turntable. The transfer mechanism in the present invention minimizes its use, and only two axes are required to complete the transfer of the cuvette 100. For large-scale chemiluminescent immunoassays, the chemiluminescent immunoassay analyzer in the present invention offers significantly higher efficiency and a simpler structure.

[0065] Finally, it should be noted that the shaft 120 may be virtual. For example, if an annular groove is provided on the body 110 and the scheduling tray 220 and the hatching tray 320 are connected to the body 110 via the first bearing 240 and the second bearing 360 respectively, then the shaft 120 may not actually exist.

[0066] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0067] The above-described embodiments merely represent several implementations of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements fall within the scope of protection of the present invention. Therefore, the scope of protection of the present utility model patent shall be determined by the appended claims.

Claims

1. A coaxial reaction disk, characterized in that: include: A main body, wherein a rotating shaft is provided on the main body; a scheduling mechanism comprising a first drive mechanism and a scheduling disk, wherein the scheduling disk is rotatably mounted on the body and is capable of rotating around the axis of the rotating shaft under the drive of the first drive mechanism, and a cuvette position is further provided on the circumference of the scheduling disk, wherein the cuvette position is used to place a cuvette; and The incubation mechanism includes a second driving mechanism and an incubation tray. The incubation tray is rotatably arranged on the body and can rotate around the axis of the rotating shaft under the drive of the second driving mechanism. The incubation tray is provided with an incubation position for placing the reaction cup.

2. A coaxial reaction disk as claimed in claim 1, characterized in that: The reaction cups are positioned around the edge of the incubation tray.

3. The coaxial reaction disk according to claim 1, characterized in that: The hatching mechanism is further provided with a heat preservation pot, which is located at the hatching position to keep the hatching position warm.

4. A coaxial reaction disk as claimed in claim 3, characterized in that: The incubation mechanism is further provided with a heat-insulating cover, which covers the incubation tray and is provided with a through hole corresponding to the incubation position, so that the reaction cup can enter the incubation position through the through hole.

5. A coaxial reaction disk as claimed in claim 4, characterized in that: A notch is provided on the edge of the heat-insulating cover, and the notch is used to locate the rotation position of the incubation mechanism.

6. The coaxial reaction disk according to claim 1, characterized in that: The first driving mechanism and / or the second driving mechanism include a motor and a transmission device, and the motor drives the scheduling disk and / or the hatching disk to rotate through the linkage of the transmission device.

7. A coaxial reaction disk as claimed in claim 6, characterized in that: The transmission device is a transmission belt.

8. The coaxial reaction disk according to claim 1, characterized in that: The scheduling mechanism includes a first bearing, which is arranged between the scheduling disk and the rotating shaft.

9. The coaxial reaction disk according to claim 1, characterized in that: The hatching mechanism includes a second bearing, which is arranged between the hatching tray and the rotating shaft.

10. A chemiluminescence immunoassay instrument, characterized in that: It comprises a shifting mechanism, a detection mechanism and the coaxial reaction disk according to any one of claims 1 to 9, wherein the shifting mechanism is used to transfer the reaction cup, and the detection mechanism is used to detect the reaction cup after incubation.

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