Mold for producing collagen membrane
Through multi-layer mold design and middle layer material processing, the problem of adhesion and separation of collagen membrane during the drying process is solved, the flatness and convenient separation of the membrane are achieved, and the production efficiency is improved.
Patent Information
- Application Number
- CN202421591978.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-08
- Publication Date
- 2025-09-30
- Estimated Expiration
- 2034-07-08
AI Technical Summary
In the prior art, collagen films are prone to wrinkling or difficulty in separation during the drying process due to poor adhesion to the mold, making it difficult to strike a balance between adhesion and separation difficulty.
The mold design adopts a multi-layer structure, including a base plate, a first and a second return frame, and an intermediate layer. The adhesion is increased by the material and surface treatment of the intermediate layer, and the return frame is used to press the intermediate layer to keep the film flat and avoid wrinkles.
It effectively solves the problem of collagen film adhesion to the mold during the drying process, ensures the flatness and easy separation of the film, and improves production efficiency.
Smart Images
Figure CN223395597U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of medical device design, in particular to a mold for producing collagen membranes. Background Art
[0002] Among absorbable membranes, collagen membranes have become ideal materials for biomembranes that guide tissue regeneration due to their good biocompatibility, degradability, low immunogenicity, and operability. Collagen is the main water-insoluble fibrin and extracellular matrix that form the skeleton outside the cell. Collagen is abundant in mammals, accounting for about 20% to 30% of the protein content in humans or other animals. It is mainly distributed in tissues such as cartilage, skin, and tendons, and plays a variety of functions in the animal body, such as support, protection, and connection. When collagen is used as a medical biomaterial, in order to maintain the appropriate morphology and strength according to the applicable part and purpose, it usually needs to be dried into a dense film or freeze-dried into a loose sponge.
[0003] Regarding the method of drying collagen solution into a dense film, the adhesion ability of collagen solution to molds of different materials is different. If the adhesion ability is poor, wrinkles will be generated during the drying process due to the pulling of the film itself, or it will be blown up or blown away; if the adhesion ability is good, it will be more difficult to separate the film from the mold after drying. It is difficult to have both, so the requirements for the mold material are high during the drying process. Utility Model Content
[0004] The purpose of this utility model is to provide a mold for producing collagen membranes, which includes the following technical solutions:
[0005] It includes a bottom plate for bearing, a first middle layer, a first return frame, and a second return frame. The first return frame is located on the bottom plate, the second return frame is located in the first return frame, and the first middle layer is located between the bottom plate and the first return frame.
[0006] Preferably, the first middle layer and the bottom plate are consistent in size and shape, the outer edge of the first return-shaped frame and the bottom plate are consistent in size and shape, and the outer edge of the second return-shaped frame and the inner edge of the first return-shaped frame are consistent in size and shape.
[0007] Preferably, the bottom plate, the first return frame and the second return frame are made of metal, including any one of stainless steel and aluminum alloy.
[0008] Preferably, the first intermediate layer includes either paper or plastic; when the material is paper, it is a paper-like material with a release effect, including either silicone oil paper or tin foil; when the material is plastic, it includes either polyethylene or polypropylene film.
[0009] Preferably, it also includes a second intermediate layer, which is larger than the second return-shaped frame and can completely cover the second return-shaped frame; the second intermediate layer is located between the second return-shaped frame and the bottom plate, and the edge of the second intermediate layer is located between the first return-shaped frame and the second return-shaped frame, and the position of the second intermediate layer is fixed by the second return-shaped frame.
[0010] Preferably, the second intermediate layer is a component of the collagen membrane product.
[0011] Preferably, the total thickness of the mold is 4.01-30.5 mm.
[0012] Preferably, the thickness of the bottom plate is 2-10 mm.
[0013] Preferably, the thickness of the first intermediate layer is 0.01-0.5 mm.
[0014] Preferably, the thickness of the first return frame is 2-20 mm.
[0015] Preferably, the thickness of the second return frame is 2-20 mm.
[0016] Beneficial effects of the utility model:
[0017] 1. By adding an intermediate layer, the adhesion problem between the collagen film and the mold is transferred to the problem of the intermediate layer; the material, surface and process of the intermediate layer can be adjusted, thereby increasing the ways to solve the problem;
[0018] 2. The first return frame and the second return frame press the first middle layer and the second middle layer respectively to keep the collagen film flat during the drying process and prevent the collagen film from wrinkling. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 This is a schematic diagram of the three-dimensional structure of a mold for producing collagen membranes according to an embodiment of the present utility model;
[0020] Figure 2 It is a schematic cross-sectional view of the internal structure of an embodiment of the present utility model;
[0021] In the figure: 1, bottom plate; 2, first return frame; 3, second return frame; 4, first middle layer; 5, second middle layer. DETAILED DESCRIPTION
[0022] To make the objectives, technical solutions, and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the following embodiments. However, it should be understood that the specific embodiments described herein are intended solely to illustrate the present invention and are not intended to limit its scope. Furthermore, descriptions of known structures and technologies are omitted in the following description to avoid unnecessary confusion regarding the concepts of the present invention.
[0023] Example 1:
[0024] In this embodiment, the bottom plate 1 has a thickness of 5 mm; the first intermediate layer 4 is a release paper with a thickness of 0.3 mm; the first return frame 2 has a thickness of 15 mm; the second return frame 3 has a thickness of 15 mm; there is no second intermediate layer 5;
[0025] Lay the base plate 1 flat, take the release paper and place it on the base plate 1, take the first return frame 2 and align the four sides of the base plate 1 and put it down, pressing the release paper; take the second return frame 3 and align the four sides of the second return frame 3 with the inner edge of the first return frame 2 and put it down, pressing the release paper;
[0026] Pour the collagen solution into the middle of the second return frame 3 and dry it into a film;
[0027] Remove the first return frame 2 and the second return frame 3, and separate the collagen film from the release paper;
[0028] When in use, the first intermediate layer 4 is covered on the bottom plate 1, and the edge of the first intermediate layer 4 is aligned with the bottom plate 1; the first return frame 2 is placed on the intermediate layer, and the outer edge of the first return frame 2 is aligned with the bottom plate 1, and the first return frame 2 presses the intermediate layer on the bottom plate 1; the second return frame 3 is placed inside the first return frame 2;
[0029] Example 2:
[0030] In this embodiment, the bottom plate 1 has a thickness of 5 mm; the first intermediate layer 4 is a release paper with a thickness of 0.015 mm; the first return frame 2 has a thickness of 15 mm; the second return frame 3 has a thickness of 15 mm; the second intermediate layer 5 is a gelatin electrospun film;
[0031] Lay the base plate 1 flat, take the release paper and spread it on the base plate 1, take the first return frame 2 and align the four sides of the base plate 1 and put it down, pressing the release paper;
[0032] The mold is placed in an electrospinning machine, and electrospinning is performed on the mold surface. To ensure uniform spinning, the spinning area is larger than the mold range; the thickness of the gelatin electrospun film is 0.05 mm; after spinning is completed, the gelatin film is cut along the outer edge of the first return frame 2, leaving only the gelatin electrospun film on the mold; at this time, the gelatin electrospun film covers the surface of the release paper inside the first return frame 2 and the upper surface of the first return frame 2;
[0033] Take the second return frame 3 and align the four sides with the inner edge of the first return frame 2 and then put it down to press the gelatin electrospun film;
[0034] Pour the collagen solution into the middle of the second return frame 3 and dry it into a film;
[0035] Remove the first return frame 2 and the second return frame 3, and separate the collagen film combined with the gelatin electrospun film from the release paper;
[0036] Example 3:
[0037] In this embodiment, the bottom plate 1 has a thickness of 10 mm; the first intermediate layer 4 is a release paper with a thickness of 0.015 mm; the first return frame 2 has a thickness of 10 mm; the second return frame 3 has a thickness of 15 mm; the second intermediate layer 5 is a gelatin electrospun film;
[0038] A groove is added at the bottom of the base plate 1 to insert a U-shaped clip; the film-making process is similar to that of Example 2. After the first return frame 2 and the second return frame 3 are lowered, U-shaped clips are used to align and reinforce them, which can increase the strength of the connection between the first return frame 2 and the second return frame 3 and the base plate 1, reduce the risk of collagen solution leaking through the bottom of the first return frame 2 and the second return frame 3 after pouring, and reduce the problem of release paper being pulled by the collagen film and causing denaturation during the drying process.
[0039] Example 4:
[0040] In this embodiment, the bottom plate 1 has a thickness of 10 mm; the first intermediate layer 4 is a polyethylene film with a thickness of 0.5 mm; the first return frame 2 has a thickness of 10 mm; the second return frame 3 has a thickness of 15 mm; and there is no second intermediate layer 5.
[0041] The polyethylene film is thick and has a smooth surface, which is not flexible enough, so the second return frame 3 is not easy to press firmly;
[0042] A groove is added at the bottom of the base plate 1 to insert a U-shaped clip; the film making process is similar to that of Example 1. After putting down the first return frame 2 and the second return frame 3, U-shaped clips are used to align and reinforce them, which can increase the strength of the connection between the first return frame 2, the second return frame 3 and the base plate 1; the risk of leakage through the bottom of the first return frame 2 and the second return frame 3 after pouring the collagen solution can be reduced, and the problem of denaturation of the release paper caused by being pulled by the collagen film during the drying process can be reduced.
[0043] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements or improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.
Claims
1. A mold for producing a collagen membrane, characterized in that: The invention comprises a bottom plate (1) for carrying, a first intermediate layer (4), a first return frame (2), and a second return frame (3), wherein the first return frame (2) is located on the bottom plate (1), the second return frame (3) is located in the first return frame (2), and the first intermediate layer (4) is located between the bottom plate (1) and the first return frame (2).
2. A mold for producing a collagen membrane according to claim 1, characterized in that: The first intermediate layer (4) and the bottom plate (1) are consistent in size and shape, the outer edge of the first return frame (2) and the bottom plate (1) are consistent in size and shape, and the outer edge of the second return frame (3) and the inner edge of the first return frame (2) are consistent in size and shape.
3. A mold for producing a collagen membrane according to claim 1, characterized in that: The base plate (1), the first return frame (2) and the second return frame (3) are made of metal, including any one of stainless steel and aluminum alloy.
4. A mold for producing a collagen membrane according to claim 1, characterized in that: The first intermediate layer (4) comprises any one of paper or plastic; when the material is paper, it is a paper-like material with a release effect, including any one of silicone oil paper and tin foil; when the material is plastic, it includes any one of polyethylene and polypropylene films.
5. The mold for producing a collagen membrane according to claim 1, wherein: The second intermediate layer (5) is also included. The second intermediate layer (5) is larger than the second return frame (3) and can completely cover the second return frame (3). The second intermediate layer (5) is located between the second return frame (3) and the bottom plate (1), and the edge of the second intermediate layer (5) is located between the first return frame (2) and the second return frame (3). The position of the second intermediate layer (5) is fixed by the second return frame (3).
6. A mold for producing a collagen membrane according to claim 5, characterized in that: The second intermediate layer (5) is a component of the collagen membrane product.
7. A mold for producing a collagen membrane according to claim 1, characterized in that: The total thickness of the mold is 4.01-30.5 mm.
8. The mold for producing a collagen membrane according to claim 1, wherein: The thickness of the bottom plate (1) is 2-10 mm.
9. The mold for producing a collagen membrane according to claim 1, wherein: The thickness of the first intermediate layer (4) is 0.01-0.5 mm.
10. The mold for producing a collagen membrane according to claim 1, wherein: The thickness of the first return frame (2) is 2-20 mm; the thickness of the second return frame (3) is 2-20 mm.