Cell separator convenient for sampling

Abstract

The utility model belongs to the technical field of cell separation, and particularly relates to a cell separator convenient for sampling. The cell separator comprises a separator shell, a screening mechanism, a dismounting and mounting mechanism and a discharging pipe, the separator shell comprises a rotating ring, a bottom plate and a supporting block, the rotating ring is arranged above the separator shell, the supporting block is arranged in the separator shell and fixedly arranged on the bottom plate, the screening mechanism is arranged in the separator shell, and the dismounting and mounting mechanism is fixedly arranged on the bottom plate. The screening mechanism is rotationally connected with the separator shell through the rotating ring, the dismounting and mounting mechanism is arranged in the separator shell and arranged at the bottom of the screening mechanism, and the discharging pipe is arranged below the separator shell. Accurate injection and airtight separation of mixed liquid are achieved, liquid leakage and external pollution are effectively prevented, and the purity and reliability of the separation process are ensured. The driving motor is matched with the high-speed rotation of the support frame, and the target cells are efficiently intercepted on the surface of the filter screen by utilizing centrifugal force, so that the purity and the precision of cell separation are remarkably improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of cell separation, and particularly relates to a cell separator which is convenient for sampling. Background Art

[0002] Cell separation technology is a key tool in biomedical research, clinical diagnosis, and cell therapy. Its core goal is to efficiently and accurately separate target cells from complex samples. Traditional cell separation devices mostly rely on manual operation or simple mechanical structures, such as centrifugation technology, which achieves cell sorting through density gradient centrifugation. However, this type of method has significant limitations: first, the separation efficiency is low and time-consuming. For example, the manual centrifugation process requires repeated adjustment of the speed and time, making it difficult to ensure the consistency of separation; second, the operation process is cumbersome, and multiple components need to be disassembled when collecting cells, which not only increases the risk of contamination but may also cause damage to cell activity; third, the sealing of traditional devices is insufficient, and the feed and discharge ports are prone to leakage of mixed liquids or intrusion of external contaminants, further affecting sample purity and experimental reliability. In addition, frequent parameter adjustments and manual intervention during the operation reduce the degree of automation and limit its application in high-throughput scenarios. Therefore, the development of an efficient, automated, and well-sealed cell separation device to overcome the shortcomings of traditional technology has become an urgent problem to be solved in this field. Utility Model Content

[0003] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, one aspect of the present invention is to provide a cell separator that is convenient for sampling, wherein the cell separator comprises a separator housing, a screening mechanism, a disassembly mechanism and a discharge pipe, wherein the separator housing comprises a rotating ring, a bottom plate and a support block, wherein the rotating ring is arranged above the separator housing, the support block is arranged in the separator housing, the support block is fixedly arranged on the bottom plate, the screening mechanism is arranged in the separator housing, the screening mechanism is rotatably connected to the separator housing through the rotating ring, the disassembly mechanism is arranged in the separator housing, the disassembly mechanism is arranged at the bottom of the screening mechanism, and the discharge pipe is arranged below the separator housing.

[0004] Preferably, the screening mechanism includes a support frame, a filter screen, a counterweight block and a feed pipe. The support frame is rotatably connected to the separator housing through a rotating ring. The filter screen is fixedly set on the support frame. The counterweight block is fixedly set on the support frame. The feed pipe is fixedly set on the support frame. The counterweight block and the feed pipe are symmetrically arranged. The feed pipe is connected to the support frame.

[0005] Preferably, a sealing cover is provided on the feed pipe, and the sealing cover is movably connected to the feed pipe.

[0006] Preferably, the screening mechanism further comprises a driving motor and a rotating block, the driving motor is fixedly arranged on the bottom plate, the output end of the driving motor is connected to the rotating block, and the rotating block is rotatably connected to the supporting block.

[0007] Preferably, the disassembly and assembly mechanism includes a mounting block and a sliding rod, the mounting block is inserted into the bottom of the support frame, the mounting block includes an insert block, the insert block is slidably set on the mounting block, the mounting block is set on the rotating block through the insert block, and the sliding rod is set in the center of the support frame.

[0008] Preferably, the sliding rod includes a pressing plate, a sliding plate, a first spring and a connecting column, the pressing plate is fixedly set on the top of the sliding rod, the pressing plate is set outside the support frame, the sliding plate is fixedly set at the bottom of the sliding rod, the sliding plate is set inside the support frame, the first spring is fixedly set at the bottom of the sliding plate, the connecting column is fixedly set at the bottom of the sliding plate, and the connecting column is set at the center of the first spring.

[0009] Preferably, the mounting block includes a pressing bevel block, an inclined slider, a fixing plate, a limiting rod and a second spring, the pressing bevel block is fixedly arranged at the bottom of the connecting column, the inclined slider is fixedly arranged on the mounting block, the pressing bevel block and the inclined surfaces of the inclined slider correspond to each other, the fixing plate is fixedly arranged on the mounting block, the limiting rod is fixedly arranged on the fixing plate, the second spring is fixedly arranged on both sides of the fixing plate, the limiting rod is arranged at the center of the second spring, the inclined slider is slidably connected to the limiting rod, the fixing plate, the limiting rod and the second spring are arranged in the middle of the inclined slider, and the insert block is fixedly arranged on the outside of the inclined slider.

[0010] Preferably, the discharge pipe includes a valve, and the valve is arranged at the outlet end of the discharge pipe.

[0011] The beneficial effects of the present invention are as follows:

[0012] By optimizing the design of the feed tube and sealing cap, this new device achieves precise injection and airtight separation of the mixed solution, effectively preventing liquid leakage and external contamination, and ensuring the purity and reliability of the separation process. The drive motor, coupled with the high-speed rotation of the support frame, utilizes centrifugal force to efficiently intercept target cells on the filter surface, while tiny impurities are discharged through the filter, significantly improving the purity and accuracy of cell separation.

[0013] In addition, the utility model discloses convenient plug -in structure design, through press the board, sliding rod and inclined block linkage mechanism, can quickly remove the support frame and the connection of rotating block, make the disassembly and cell collection of filter screen more simple, greatly promote the operation efficiency. The buffer reset function of first spring and second spring reduces mechanical impact, reduces the component wear and tear, prolongs the service life of device. The overall structure design is reasonable, and the operation is convenient, and the separation efficiency is high, is applicable to biomedical research, clinical diagnosis and cell therapy etc. A variety of application scenarios.

[0014] The additional aspects and advantages of the utility model will become apparent in the following description, or be appreciated by practice of the utility model. BRIEF DESCRIPTION OF DRAWINGS

[0015] The drawings described here are used to provide further understanding of the utility model, and constitute a part of this application, and the illustrative embodiment of the utility model and its explanation are used to explain the utility model, and do not constitute undue limitation to the utility model. In the drawings:

[0016] Figure 1 It is cell separator structure schematic view of the utility model;

[0017] Figure 2 It is cell separator structure sectional view of the utility model;

[0018] Figure 3 It is cell separator screening mechanism structure schematic view of the utility model;

[0019] Figure 4 It is cell separator of the utility model Figure 3 A portion enlarged view in the utility model;

[0020] Figure 5 It is cell separator of the utility model Figure 2 B portion enlarged view in the utility model;

[0021] Among them, the corresponding relationship between the reference signs in the drawing and the component name is:

[0022] 1 is separator shell, 11 is rotating ring, 12 is bottom plate, 13 is support block, 2 is screening mechanism, 21 is support frame, 22 is filter screen, 23 is counterweight, 24 is feed pipe, 241 is sealing cover, 25 is driving motor, 26 is rotating block, 3 is dismounting mechanism, 31 is mounting block, 311 is plug, 312 is press inclined block, 313 is inclined slide block, 314 is fixed plate, 315 is limit rod, 316 is second spring, 32 is sliding rod, 321 is press board, 322 is sliding plate, 323 is first spring, 324 is connecting column, 4 is discharge pipe, 41 is valve. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0024] In the description of this utility model, it should be noted that, unless otherwise expressly specified or limited, the terms "connected" and "connection" should be understood in a broad sense. For example, they can refer to fixed connection, detachable connection, or integral connection; mechanical connection, electrical connection; direct connection, indirect connection through an intermediate medium, or internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in this utility model based on the specific circumstances.

[0025] The cell separator for convenient sampling of the present invention includes a separator housing 1, a rotating ring 11, a bottom plate 12, a support block 13, a screening mechanism 2, a support frame 21, a filter screen 22, a counterweight block 23, a feed pipe 24, a sealing cover 241, a drive motor 25, a rotating block 26, a disassembly and assembly mechanism 3, a mounting block 31, an insert block 311, a pressing inclined block 312, an inclined slider 313, a fixing plate 314, a limiting rod 315, a second spring 316, a sliding rod 32, a pressing plate 321, a sliding plate 322, a first spring 323, a connecting column 324, a discharge pipe 4 and a valve 41.

[0026] like Figure 1 、 2 As shown, the rotating ring 11 is arranged above the separator housing 1, the support block 13 is arranged in the separator housing 1, the support block 13 is fixedly arranged on the bottom plate 12, the screening mechanism 2 is arranged in the separator housing 1, and the screening mechanism 2 is rotatably connected to the separator housing 1 through the rotating ring 11. The disassembly and assembly mechanism 3 is arranged in the separator housing 1, and the disassembly and assembly mechanism 3 is arranged at the bottom of the screening mechanism 2. The discharge pipe 4 is arranged below the separator housing 1, and the valve 41 is arranged at the outlet end of the discharge pipe 4.

[0027] like Figure 3 As shown, the support frame 21 is rotatably connected to the separator housing 1 through the rotating ring 11, the filter screen 22 is fixedly set on the support frame 21, the counterweight block 23 is fixedly set on the support frame 21, the feed pipe 24 is fixedly set on the support frame 21, the counterweight block 23 and the feed pipe 24 are symmetrically arranged, the feed pipe 24 is connected to the support frame 21, the sealing cover 241 is movably connected to the feed pipe 24, the drive motor 25 is fixedly set on the bottom plate 12, the output end of the drive motor 25 is connected to the rotating block 26, and the rotating block 26 is rotatably connected to the support block 13.

[0028] like Figure 4 、 5 As shown, the mounting block 31 is inserted into the bottom of the support frame 21 , the inserting block 311 is slidably set on the mounting block 31 , the mounting block 31 is set on the rotating block 26 through the inserting block 311 , and the sliding rod 32 is set in the center of the support frame 21 .

[0029] The pressing plate 321 is fixedly set on the top of the sliding rod 32, the pressing plate 321 is set outside the support frame 21, the sliding plate 322 is fixedly set at the bottom of the sliding rod 32, the sliding plate 322 is set inside the support frame 21, the first spring 323 is fixedly set at the bottom of the sliding plate 322, the connecting column 324 is fixedly set at the bottom of the sliding plate 322, and the connecting column 324 is set at the center of the first spring 323.

[0030] The pressing bevel block 312 is fixed at the bottom of the connecting column 324, the inclined slider 313 is fixed on the mounting block 31, the pressing bevel block 312 and the inclined slider 313 correspond to each other, the fixing plate 314 is fixed on the mounting block 31, the limiting rod 315 is fixed on the fixing plate 314, the second spring 316 is fixed on both sides of the fixing plate 314, the limiting rod 315 is set at the center of the second spring 316, the inclined slider 313 is slidably connected with the limiting rod 315, the fixing plate 314, the limiting rod 315 and the second spring 316 are set in the middle of the inclined slider 313, and the insert block 311 is fixed on the outside of the inclined slider 313.

[0031] When using the cell separator, first, the mixed liquid to be separated is injected into the interior of the support frame 21 through the feed pipe 24. After the injection is completed, the sealing cover 241 is covered to ensure the airtightness of the interior of the support frame 21 and provide a stable environment for the subsequent separation process. At this time, the drive motor 25 can be started, and the output end of the drive motor 25 drives the rotating block 26 to rotate stably inside the support block 13. The rotating block 26 and the support frame 21203 are detachably connected by the mounting block 31 and the insert block 311. Therefore, the rotation of the rotating block 26 will drive the support frame 21 to rotate synchronously. The mixed liquid inside the support frame 21 is pushed to the surface of the filter screen 22 under the action of centrifugal force. During rotation, the counterweight block 23 and the feed pipe 24 can maintain left and right mass balance;

[0032] During the rotation of the support frame 21, the mixed liquid is pushed to the surface of the filter 22 under the action of centrifugal force. The pore size design of the filter 22 can effectively intercept the desired cells, while smaller impurities or unnecessary components pass through the filter 22 and enter the bottom of the separator housing 1. Through this screening method, the desired cells are retained inside the filter 22, achieving preliminary cell separation.

[0033] After the separation is completed, the operator presses the pressing plate 321, which drives the sliding rod 32 to move downward. The bottom of the sliding rod 32 is fixedly connected to the sliding plate 322. The sliding plate 322 moves downward as the sliding rod 32 moves downward. When the sliding plate 322 moves downward, the pressing inclined block 312 will contact the inclined sliding block 313 inside the mounting block 31. The inclined surface design of the pressing inclined block 312 makes the inclined sliding block 313 slide after contact. The movement of the inclined sliding block 313 drives the inserting block 311 to move toward the inside of the mounting block 31.

[0034] When the insert block 311 moves toward the inside of the mounting block 31 and detaches from the mounting block 31, the connection between the support frame 21 and the rotating block 26 is released. At this time, the operator can easily pull the support frame 21 out of the rotating block 26. A filter screen 22 is provided inside the support frame 21, and the required cells remain on the filter screen 22. The operator only needs to remove the sealing cover 241 to collect the cells, and open the valve 41 to discharge the unnecessary components from the discharge pipe 4.

[0035] The above only describes in detail the preferred embodiments of the present invention, but the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by ordinary technicians in this field, various changes can be made without departing from the purpose of the present invention, and various changes should be included in the scope of protection of the present invention.

Claims

1. A cell separator for convenient sampling, characterized by: The cell separator comprises a separator housing (1), a screening mechanism (2), a disassembly mechanism (3) and a discharge pipe (4); the separator housing (1) comprises a rotating ring (11), a bottom plate (12) and a support block (13); the rotating ring (11) is arranged above the separator housing (1); the support block (13) is arranged in the separator housing (1); the support block (13) is fixedly arranged on the bottom plate (12); the screening mechanism (2) is arranged in the separator housing (1); the screening mechanism (2) is rotatably connected to the separator housing (1) through the rotating ring (11); the disassembly mechanism (3) is arranged in the separator housing (1); the disassembly mechanism (3) is arranged at the bottom of the screening mechanism (2); and the discharge pipe (4) is arranged below the separator housing (1).

2. A cell separator for convenient sampling according to claim 1, characterized in that: The screening mechanism (2) comprises a support frame (21), a filter screen (22), a counterweight (23) and a feed pipe (24); the support frame (21) is rotatably connected to the separator housing (1) via a rotating ring (11); the filter screen (22) is fixedly arranged on the support frame (21); the counterweight (23) is fixedly arranged on the support frame (21); the feed pipe (24) is fixedly arranged on the support frame (21); the counterweight (23) and the feed pipe (24) are symmetrically arranged; and the feed pipe (24) is communicated with the support frame (21).

3. A cell separator for convenient sampling according to claim 2, characterized in that: A sealing cover (241) is provided on the feed pipe (24), and the sealing cover (241) is movably connected to the feed pipe (24).

4. A cell separator for convenient sampling according to claim 2, characterized in that: The screening mechanism (2) further comprises a driving motor (25) and a rotating block (26), wherein the driving motor (25) is fixedly arranged on the bottom plate (12), an output end of the driving motor (25) is connected to the rotating block (26), and the rotating block (26) is rotatably connected to the supporting block (13).

5. The cell separator for convenient sampling according to claim 4, characterized in that: The disassembly and assembly mechanism (3) comprises a mounting block (31) and a sliding rod (32); the mounting block (31) is plugged into the bottom of the support frame (21); the mounting block (31) comprises an insert block (311); the insert block (311) is slidably arranged on the mounting block (31); the mounting block (31) is arranged on the rotating block (26) via the insert block (311); and the sliding rod (32) is arranged at the center of the support frame (21).

6. The cell separator for convenient sampling according to claim 5, characterized in that: The sliding rod (32) includes a pressing plate (321), a sliding plate (322), a first spring (323) and a connecting column (324), wherein the pressing plate (321) is fixedly arranged at the top of the sliding rod (32), the pressing plate (321) is arranged outside the support frame (21), the sliding plate (322) is fixedly arranged at the bottom of the sliding rod (32), the sliding plate (322) is arranged inside the support frame (21), the first spring (323) is fixedly arranged at the bottom of the sliding plate (322), the connecting column (324) is fixedly arranged at the bottom of the sliding plate (322), and the connecting column (324) is arranged at the center of the first spring (323).

7. The cell separator for convenient sampling according to claim 6, characterized in that: The mounting block (31) includes a pressing inclined block (312), an inclined sliding block (313), a fixing plate (314), a limiting rod (315) and a second spring (316). The pressing inclined block (312) is fixedly arranged at the bottom of the connecting column (324). The inclined sliding block (313) is fixedly arranged on the mounting block (31). The inclined surfaces of the pressing inclined block (312) and the inclined sliding block (313) correspond to each other. The fixing plate (314) is fixedly arranged on the mounting block (31). The limiting rod (315) is fixedly arranged on the fixed plate (314), the second spring (316) is fixedly arranged on both sides of the fixed plate (314), the limiting rod (315) is arranged at the center of the second spring (316), the inclined slider (313) is slidably connected to the limiting rod (315), the fixed plate (314), the limiting rod (315) and the second spring (316) are arranged in the middle of the inclined slider (313), and the insert (311) is fixedly arranged outside the inclined slider (313).

8. The cell separator for convenient sampling according to claim 1, characterized in that: The discharge pipe (4) comprises a valve (41), and the valve (41) is arranged at the outlet end of the discharge pipe (4).

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