Extraction layering reaction kettle for rosuvastatin intermediate production

Abstract

The utility model discloses an extraction layering reaction kettle for producing a rosuvastatin intermediate, which relates to the technical field of medicine extraction and comprises a sealing barrel and a centrifugal barrel, a conveying pipe is arranged on the sealing barrel, the centrifugal barrel is rotatably arranged in the sealing barrel, and the conveying pipe is connected with the centrifugal barrel. A driving assembly used for driving the centrifugal barrel to rotate is arranged on the sealing barrel, a discharging pipe penetrating through the sealing barrel is arranged at the bottom of the centrifugal barrel, a control valve is fixedly connected to the discharging pipe, and an air pressure balance assembly is arranged at the top of the sealing barrel. When the centrifugal machine is used, the motor can drive the connecting disc to rotate, the rotating connecting disc drives the centrifugal barrel to rotate through the connecting rod, so that a layered solution in the centrifugal barrel generates centrifugal force, and due to the fact that the mass of water is large, the edge of a rotating water layer can gradually rise upwards along the inner wall of the centrifugal barrel, and meanwhile the middle of the water layer is sunken. Therefore, the contact area of the water layer and the toluene layer is increased, and the extraction efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of drug extraction, in particular to an extraction and stratification reactor for producing rosuvastatin intermediates. Background Art

[0002] Drug extraction refers to the process of separating the active ingredients from impurities in pharmaceutical raw materials through physical or chemical means to obtain high-purity, high-concentration active ingredients. These active ingredients are usually the main active ingredients of the drug and play a key role in treating diseases.

[0003] During the processing of the drug rosuvastatin, a reactor is a frequently used and important processing tool. It is used for a variety of process operations, including chemical reactions, mixing, dissolving, and extraction, and plays a key role in the synthesis, purification, and modification of rosuvastatin. During extraction, a certain amount of toluene is injected into the reactor or recycled toluene is stirred for 30-60 minutes to ensure dissolution. The feed liquid is then transferred to another set of reactors through a filter. Potassium carbonate solution is then added to the reactor through a filter, stirred for 30 minutes, and allowed to stand for 30 minutes. The solution is separated into layers, and the lower aqueous layer is discarded, completing the extraction process.

[0004] The shortcomings of the existing technical solution are that after stirring is completed, the solution will gradually separate into a toluene layer and a water layer, and the mixed drug components will gradually transfer from the water layer to the inside of the toluene layer, thereby achieving an extraction effect. However, this process mainly relies on the natural sedimentation method to separate the substances, and the separation efficiency is low. Utility Model Content

[0005] The purpose of the utility model is to provide an extraction and stratification reactor for the production of rosuvastatin intermediates, so as to solve the technical problem that the extraction process in the prior art mainly relies on the natural sedimentation method for material separation and the separation efficiency is low.

[0006] The technical problem to be solved by the present invention can be achieved through the following technical solutions:

[0007] An extraction and stratification reactor for the production of rosuvastatin intermediates includes a sealed barrel with a feed pipe provided on the sealed barrel. The device also includes a centrifugal barrel, which is rotatably arranged inside the sealed barrel. The sealed barrel is provided with a drive assembly for driving the centrifugal barrel to rotate. A discharge pipe that passes through the sealed barrel is provided at the bottom of the centrifugal barrel, a control valve is fixedly connected to the discharge pipe, and an air pressure balance assembly is provided on the top of the sealed barrel.

[0008] As a further scheme of the utility model: the driving assembly includes motor fixedly connected on the sealed barrel, the connecting block is fixedly connected on the top of the sealed barrel, the connecting disc is rotatably connected on the bottom of the connecting block, the motor output end penetrates the connecting block and is coaxially fixedly connected with the connecting disc, the connecting rod is fixedly connected between the centrifugal barrel and the connecting disc.

[0009] As a further scheme of the utility model: the upper end of the centrifugal barrel is cylindrical, and the lower end of the centrifugal barrel is inverted conical.

[0010] As a further scheme of the utility model: a plurality of driving plates are fixedly connected on the inner wall of the centrifugal barrel at equal intervals.

[0011] As a further scheme of the utility model: the air pressure balance assembly includes balance pipe fixedly connected on the sealed barrel, and the air pressure sensor is arranged on the balance pipe.

[0012] As a further scheme of the utility model: the support block that is rotatably matched with the centrifugal barrel is coaxially fixedly connected on the bottom of the sealed barrel, and the limiting ring that is rotatably matched with the centrifugal barrel is coaxially fixedly connected on the inner wall of the sealed barrel.

[0013] The utility model discloses the beneficial effects of:

[0014] The utility model discloses when using, can drive the connecting disc rotation through motor, and the connecting disc of rotation drives the centrifugal barrel rotation through the connecting rod, makes the solution of the centrifugal barrel after partial layer produces centrifugal force, and because the quality of water is larger, makes the water layer edge in rotation and gradually rises along the centrifugal barrel inner wall, and recesses in the middle, thereby increase the contact area of water layer and toluene layer, improve the possible of drug component and toluene layer contact, simultaneously, because the density of water is larger, under the action of centrifugal force, drug molecules are more easily squeezed from water layer to toluene layer, thereby improve extraction efficiency. DRAWINGS

[0015] The utility model will be further described in connection with the drawings.

[0016] Fig. 1 It is the whole structure schematic diagram of the utility model;

[0017] Fig. 2 It is the whole longitudinal section structure schematic diagram of the utility model;

[0018] Fig. 3 It is the centrifugal barrel longitudinal section structure schematic diagram of the utility model.

[0019] In the figure: 1. Sealing barrel; 2. Centrifugal barrel; 3. Motor; 4. Feed pipe; 5. Balance pipe; 6. Discharge pipe; 7. Control valve; 8. Connecting block; 9. Connecting plate; 10. Connecting rod; 11. Driving plate; 12. Limiting ring; 13. Support block; 14. Air pressure sensor. DETAILED DESCRIPTION

[0020] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0021] like Figs. 1-3 As shown, an extraction and stratification reactor for the production of rosuvastatin intermediates includes a sealed barrel 1, which is provided with a feed pipe 4, through which the stirred solution can be introduced into the sealed barrel 1. The device also includes a centrifugal barrel 2, which is used to provide a carrying environment for the solution to be layered and extracted, so that the solution is gradually divided into a water layer and a toluene layer. The centrifugal barrel 2 is rotatably arranged inside the sealed barrel 1, and a driving component for driving the centrifugal barrel 2 to rotate is provided on the sealed barrel 1. The driving component drives the centrifugal barrel 2 to rotate, so that the stratified solution inside the centrifugal barrel 2 generates centrifugal force, and due to the large mass of water, the edge of the rotating water layer will gradually rise along the inner wall of the centrifugal barrel 2, and at the same time, the middle is concave, thereby increasing the contact area between the water layer and the toluene layer, thereby increasing the possibility of contact between the drug components and the toluene layer. At the same time, due to the large density of water, under the action of centrifugal force, the drug molecules are more easily squeezed from the water layer into the toluene layer, thereby improving the extraction efficiency. A plurality of driving plates 11 are fixedly connected at equal intervals around the inner wall of the centrifugal barrel 2. The driving plates 11 drive the water layer to move, thereby improving the transmission effect of the centrifugal barrel 2. A discharge pipe 6 is provided at the bottom of the centrifugal barrel 2 and passes through the sealed barrel 1. The separation of the water layer is achieved through the discharge pipe 6. A control valve 7 is fixedly connected to the discharge pipe 6. The control valve 7 can control the penetration state of the discharge pipe 6. An air pressure balancing component is provided on the top of the sealed barrel 1. The air pressure balancing component is used to balance the internal air pressure of the sealed barrel 1, thereby facilitating the output of materials.

[0022] In some specific embodiments, in order to achieve the rotating effect of the centrifugal barrel 2, the driving assembly comprises a motor 3 fixedly connected to the sealed barrel 1, a connecting block 8 fixedly connected to the top of the sealed barrel 1, a connecting disc 9 rotatably connected to the bottom of the connecting block 8, the connecting block 8 being hollow, the output end of the motor 3 being coaxially fixedly connected to the connecting disc 9 after penetrating through the connecting block 8, the motor 3 being capable of driving the connecting disc 9 to rotate, a plurality of connecting rods 10 being fixedly connected between the centrifugal barrel 2 and the connecting disc 9, the rotating connecting disc 9 driving the centrifugal barrel 2 to rotate through the connecting rods 10, thereby achieving the rotating effect of the centrifugal barrel 2.

[0023] In some specific embodiments, in order to ensure the stability of the centrifugal barrel 2 during rotation, a support block 13 rotatably matched with the centrifugal barrel 2 is coaxially fixedly connected to the bottom of the sealed barrel 1, and a limiting ring 12 rotatably matched with the centrifugal barrel 2 is coaxially fixedly connected to the inner wall of the sealed barrel 1, and the support block 13 and the limiting ring 12 are both provided with balls matched with the centrifugal barrel 2, thereby ensuring the stability of the centrifugal barrel 2 during rotation.

[0024] In some specific embodiments, in order to facilitate the separation of the water layer and the toluene layer, the upper end of the centrifugal barrel 2 is in a cylindrical shape, and the lower end of the centrifugal barrel 2 is in an inverted conical shape, when the water layer is removed, the control valve 7 can be opened, so that the water layer flows out from the inside of the centrifugal barrel 2 through the discharge pipe 6, thereby achieving the separation of the water layer and the toluene layer, and the lower end of the centrifugal barrel 2 being in an inverted conical shape can reduce the possibility of water layer residue and ensure the separation effect.

[0025] In some specific embodiments, in order to ensure the air pressure balance inside the sealed barrel 1, the air pressure balance assembly comprises a balance pipe 5 fixedly connected to the sealed barrel 1, the other end of the balance pipe 5 being connected to a gas cylinder provided with a gas filling valve, and the balance pipe 5 being provided with an air pressure sensor 14, when the centrifugal barrel 2 is discharging, the air pressure sensor 14 detects that the air pressure inside the sealed barrel 1 decreases, at this time, the balance pipe 5 injects gas into the sealed barrel 1, thereby ensuring the normal discharge of the centrifugal barrel 2.

[0026] In order to facilitate the understanding of the embodiments of the present scheme by those skilled in the art, the working principle of the embodiments of the present scheme will be described in conjunction with specific application scenarios:

[0027] In use, the stirred solution is introduced into the centrifugal barrel 2 through the feed pipe 4, and after standing, the solution is gradually separated into a water layer and a toluene layer. The motor 3 is then started to drive the connecting disc 9 to rotate, and the rotating connecting disc 9 drives the centrifugal barrel 2 to rotate through the connecting rod 10, so that the solution in the centrifugal barrel 2 is subjected to centrifugal force. Since the water has a large mass, the edge of the rotating water layer gradually rises along the inner wall of the centrifugal barrel 2 and is concave in the middle, thereby increasing the contact area of the water layer and the toluene layer and improving the possibility of contact between the drug components and the toluene layer. At the same time, since the water has a large density, the drug molecules are more easily squeezed from the water layer into the toluene layer under the action of centrifugal force, thereby improving the extraction efficiency.

[0028] When the water layer is removed, the control valve 7 can be opened to allow the water layer to flow out through the discharge pipe 6, thereby separating the water layer from the toluene layer. The lower end of the centrifugal barrel 2 is in the shape of an inverted cone, which can reduce the possibility of water layer residue and ensure the separation effect. When the centrifugal barrel 2 is discharging, the air pressure sensor 14 detects a decrease in the air pressure inside the sealed barrel 1, and at this time the balance pipe 5 injects gas into the sealed barrel 1, thereby ensuring the normal discharge of the centrifugal barrel 2.

[0029] The above describes one embodiment of the present application in detail, but the above description is only a preferred embodiment of the present application and cannot be considered as limiting the scope of the present application. Any equivalent changes and improvements made within the scope of the present application should still be considered within the scope of the present application.

Claims

1. An extraction and delamination reactor for the production of rosuvastatin intermediates, comprising a sealed barrel (1) provided with a feed pipe (4), characterized in that , also includes: A centrifugal bucket (2) is rotatably arranged inside a sealed bucket (1); a driving assembly for driving the centrifugal bucket (2) to rotate is provided on the sealed bucket (1); a discharge pipe (6) penetrating the sealed bucket (1) is provided at the bottom of the centrifugal bucket (2); a control valve (7) is fixedly connected to the discharge pipe (6); and an air pressure balance assembly is provided on the top of the sealed bucket (1).

2. The extraction and demixing reactor for producing rosuvastatin intermediates according to claim 1, characterized in that: The driving assembly comprises a motor (3) fixedly connected to a sealed barrel (1); a connecting block (8) is fixedly connected to the top of the sealed barrel (1); a connecting disk (9) is rotatably connected to the bottom of the connecting block (8); an output end of the motor (3) passes through the connecting block (8) and is coaxially fixedly connected to the connecting disk (9); and a connecting rod (10) is fixedly connected between the centrifugal barrel (2) and the connecting disk (9).

3. The extraction and demixing reactor for producing rosuvastatin intermediates according to claim 1, characterized in that: The upper end of the centrifugal barrel (2) is cylindrical, and the lower end of the centrifugal barrel (2) is in the shape of an inverted cone.

4. The extraction and demixing reactor for producing rosuvastatin intermediates according to claim 1, characterized in that: A plurality of groups of driving plates (11) are fixedly connected around the inner wall of the centrifugal barrel (2) at equal intervals.

5. The extraction and demixing reactor for producing rosuvastatin intermediates according to claim 1, characterized in that: The air pressure balancing assembly comprises a balancing pipe (5) fixedly connected to the sealing barrel (1), and an air pressure sensor (14) is provided on the balancing pipe (5).

6. The extraction and demixing reactor for producing rosuvastatin intermediates according to claim 1, characterized in that: The bottom of the sealing barrel (1) is coaxially fixedly connected to a support block (13) that rotates with the centrifugal barrel (2), and the inner wall of the sealing barrel (1) is coaxially fixedly connected to a limiting ring (12) that rotates with the centrifugal barrel (2).

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