Small swinging reaction kettle
By designing a small swing reactor and using a stepper motor to control the swing angle and speed, the problems of uneven stirring and difficult maintenance in solid-phase peptide reactors are solved, achieving more efficient material mixing and reaction quality, which is suitable for the biopharmaceutical field.
Patent Information
- Application Number
- CN202423053540.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-11
- Publication Date
- 2025-10-31
- Estimated Expiration
- 2034-12-11
AI Technical Summary
Existing solid-phase peptide reactors are prone to generating bubbles during stirring, leading to unstable reaction results, uneven material mixing, inconvenient maintenance of the stirring device, and easy damage to peptide chains, thus affecting reaction efficiency.
A small swing reactor is used, with a stepper motor controlling the swing angle and speed. The material is mixed evenly through a drive shaft and a swing support, avoiding damage to the peptide chains by the stirring paddle.
It improves the uniformity of material mixing and reaction efficiency, reduces maintenance costs, and provides higher synthesis quality and efficiency, making it suitable for the biopharmaceutical field.
Smart Images
Figure CN223490975U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of chemical technology, specifically to a small swing reactor. Background Technology
[0002] A solid-phase peptide reactor is a device used to synthesize peptides. It employs solid-phase synthesis technology, adding amino acids one by one into the reactor, where they are chemically linked on resin to form peptide chains. Solid-phase peptide reactors offer advantages such as high efficiency, automation, and strong controllability, and are widely used in the biomedical field.
[0003] Solid-phase peptide reactors are typically equipped with a stirrer, which includes a drive mechanism, a stirring shaft (including a shaft seal), and an impeller (stirring paddle). There are hundreds or even thousands of types of stirred reactors used in industry, and different types and materials of stirring shafts and stirring paddles can be selected according to the materials and temperature.
[0004] However, due to the potential generation of bubbles during the stirring process, which can affect the reaction effect; unstable stirring fluidity leading to uneven mixing of materials; the need for corresponding corrosion-resistant materials in the stirring device, making subsequent maintenance inconvenient; and especially the tendency of the impeller to break down peptide chains during synthesis, resulting in low reaction efficiency, solid-phase peptide reactors will play an increasingly important role as the biomedical field continues to develop, making the invention of a new mixing method increasingly important.
[0005] In view of this, the present invention proposes a small swing reactor. Utility Model Content
[0006] This invention proposes a small-scale swing reactor, which solves related technical and chemical problems.
[0007] The technical solution of this utility model is as follows: A small swing reactor includes a frame body, a frame support fixedly connected to the top of the frame body, a coupling mounting hole provided inside the frame support, a stepper motor provided on one side of the frame support, a coupling body located inside the coupling mounting hole fixedly connected to the output end of the stepper motor, a drive shaft body fixedly connected inside the coupling body, a drive shaft support fixedly connected to the surface of the drive shaft body, a swing support body inserted inside the drive shaft support, a first swing support fixing hole provided on the surface of the drive shaft support, a reactor body fixedly connected to the tail of the swing support body, a lower flange body fixedly connected to the top of the reactor body, a second swing support fixing hole provided on both sides of the lower flange body, swing support mounting holes provided at both ends of the second swing support fixing holes, a lower flange mounting hole provided inside the lower flange body, an upper flange body fitted to the top of the lower flange body, an upper flange mounting hole provided inside the upper flange body, a reactor cover fixedly connected to the top of the upper flange body, and rollers fixedly connected to the bottom of the frame body.
[0008] Preferably, the drive shaft body is made of a smooth round lead screw, and the surface of the drive shaft body is coated with chrome plating.
[0009] Preferably, the drive shaft bracket is made of stainless steel.
[0010] Preferably, the first fixing hole and the second fixing hole of the swing bracket are through holes used to fix the swing bracket body.
[0011] Preferably, the coupling body is used to connect the drive shaft body and the stepper motor.
[0012] Preferably, both the upper fixing hole and the lower fixing hole of the swing bracket are provided with threads, and the positions of the first fixing hole and the mounting hole of the swing bracket correspond to the upper fixing hole and the lower fixing hole of the swing bracket, respectively.
[0013] Preferably, the upper flange mounting holes and the lower flange mounting holes are each provided in four sets at equal intervals, and the upper flange body and the lower flange body are tightly fitted together.
[0014] Preferably, the frame support is made of stainless steel and welded to the left and right sides of the frame body.
[0015] The working principle and beneficial effects of this utility model are as follows:
[0016] 1. In this utility model, the angle and speed of the oscillation can be controlled by an integrated stepper motor driven and controlled by a host computer, based on the characteristics of the material. It has advantages such as high precision, simple structure, convenient maintenance, and low cost, and is a novel small-scale solid-phase synthesis reactor.
[0017] 2. This invention avoids the problem of peptide chains being broken by the stirring paddle in solid-phase synthesis reactions, while making the liquid mixing more uniform, which can greatly improve the synthesis efficiency and quality, and provide strong support for research and development in the field of biomedicine. Attached Figure Description
[0018] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.
[0019] Figure 1 This is a three-dimensional structural diagram of the present invention;
[0020] Figure 2 This is a schematic diagram of the second fixing hole structure of the swing bracket of this utility model;
[0021] Figure 3 This is a schematic diagram of the upper flange mounting hole structure of this utility model;
[0022] Figure 4 This is a schematic diagram of the lower fixing hole structure of the swing bracket of this utility model;
[0023] Figure 5 This is a schematic diagram of the first fixing hole structure of the swing bracket of this utility model;
[0024] Figure 6 This is a schematic diagram of the coupling body structure of this utility model;
[0025] Figure 7 This is a schematic diagram of the coupling mounting hole structure of this utility model.
[0026] In the diagram: 1. Frame body; 2. Frame bracket; 3. Stepper motor; 4. Coupling body; 5. Drive shaft body; 6. Drive shaft bracket; 7. Swing bracket body; 8. Lower fixing hole of swing bracket; 9. Upper fixing hole of swing bracket; 10. First fixing hole of swing bracket; 11. Lower flange body; 12. Second fixing hole of swing bracket; 13. Swing bracket mounting hole; 14. Lower flange mounting hole; 15. Upper flange body; 16. Upper flange mounting hole; 17. Reactor body; 18. Reactor cover; 19. Roller; 20. Coupling mounting hole. Detailed Implementation
[0027] The technical solutions of this utility model will be clearly and completely described below with reference to the embodiments of this utility model. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this utility model.
[0028] Example
[0029] A preferred embodiment of the small swing reactor provided by this utility model is, for example... Figures 1 to 5 As shown: A small swing reactor includes a frame body 1, a frame support 2 fixedly connected to the top of the frame body 1, a coupling mounting hole 20 provided inside the frame support 2, a stepper motor 3 provided on one side of the frame support 2, a coupling body 4 located inside the coupling mounting hole 20 fixedly connected to the output end of the stepper motor 3, a drive shaft body 5 fixedly connected inside the coupling body 4, a drive shaft support 6 fixedly connected to the surface of the drive shaft body 5, a swing support body 7 inserted inside the drive shaft support 6, and a first fixing hole 10 for the swing support provided on the surface of the drive shaft support 6. The tail of the swing bracket body 7 is fixedly connected to the vessel body 17, the top of the vessel body 17 is fixedly connected to the lower flange body 11, the lower flange body 11 is provided with second fixing holes 12 for the swing bracket on both sides, the two ends of the second fixing holes 12 for the swing bracket are provided with swing bracket mounting holes 13, the lower flange body 11 is provided with lower flange mounting holes 14 inside, the top of the lower flange body 11 is fitted with an upper flange body 15, the upper flange body 15 is provided with upper flange mounting holes 16 inside, the top of the upper flange body 15 is fixedly connected to the vessel cover 18, and the bottom of the frame body 1 is fixedly connected to a roller 19.
[0030] In this embodiment, the drive shaft body 5 is made of a smooth round lead screw, and the surface of the drive shaft body 5 is coated with chrome plating, which can increase the hardness and corrosion resistance of the drive shaft body 5.
[0031] In this embodiment, the drive shaft bracket 6 is made of stainless steel 304, which can prevent rust from forming on the drive shaft bracket 6 and enhance its durability.
[0032] In this embodiment, the first fixing hole 10 and the second fixing hole 12 of the swing bracket are through holes used to fix the swing bracket body 7, which can stably fix the swing bracket body 7 inside the transmission shaft bracket 6.
[0033] In this embodiment, the coupling body 4 is used to connect the transmission shaft body 5 and the stepper motor 3. The stepper motor 3 can be set as needed to adjust the swing angle and speed, and the transmission shaft body 5 can be locked when swinging is not required.
[0034] In this embodiment, both the upper fixing hole 9 and the lower fixing hole 8 of the swing bracket are provided with threads, and the positions of the first fixing hole 10 and the mounting hole 13 of the swing bracket correspond to the upper fixing hole 9 and the lower fixing hole 8 of the swing bracket, respectively.
[0035] In this embodiment, four sets of mounting holes 16 on the upper flange and 14 on the lower flange are equidistantly arranged, and the upper flange body 15 and the lower flange body 11 are tightly fitted together.
[0036] In this embodiment, the frame bracket 2 is made of stainless steel 304 and welded to the left and right sides of the frame body 1. By setting two sets of frame brackets 2, the connection of the transmission shaft body 5 can be made more stable.
[0037] The working principle and usage process of this utility model are as follows: First, two frame supports 2 are symmetrically arranged on the top of the frame body 1. A stepper motor 3 is concentrically arranged on one side of the two frame supports 2, and a coupling body 4 is concentrically arranged on the other side. The coupling body 4 connects the transmission shaft body 5 and the output shaft of the stepper motor 3. A transmission shaft support 6 is concentrically arranged on each side of the transmission shaft body 5. A swing support body 7 is respectively arranged at the lower end of the two sets of transmission shaft supports 6. The swing support body 7 is connected to the lower flange body 11. The lower flange body 11 and the upper flange body 15 are connected by screws in the lower flange mounting hole 14 and the upper flange mounting hole 16. The upper and lower flange bodies 11 and the upper flange body 15 are connected together with the lid 18 and the body 17. The swing angle and speed can be adjusted as needed by the stepper motor 3. When swinging is not needed, the transmission shaft body 5 is locked.
[0038] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model shall be included within the protection scope of the present utility model.
Claims
1. A small swing reactor, comprising a frame body (1), characterized in that, A frame bracket (2) is fixedly connected to the top of the frame body (1). A coupling mounting hole (20) is provided inside the frame bracket (2). A stepper motor (3) is provided on one side of the frame bracket (2). A coupling body (4) located inside the coupling mounting hole (20) is fixedly connected to the output end of the stepper motor (3). A transmission shaft body (5) is fixedly connected inside the coupling body (4). A transmission shaft bracket (6) is fixedly connected to the surface of the transmission shaft body (5). A swing bracket body (7) is inserted inside the transmission shaft bracket (6). A first fixing hole (10) for the swing bracket is provided on the surface of the transmission shaft bracket (6). The tail is fixedly connected to the vessel body (17), the top of the vessel body (17) is fixedly connected to the lower flange body (11), the lower flange body (11) is provided with a second fixing hole (12) for the swing bracket on both sides, the two ends of the second fixing hole (12) for the swing bracket are provided with swing bracket mounting holes (13), the lower flange body (11) is provided with a lower flange mounting hole (14) inside, the upper flange body (15) is attached to the top of the lower flange body (11), the upper flange body (15) is provided with an upper flange mounting hole (16) inside, the upper flange body (15) is fixedly connected to the top of the upper flange body (15) and the bottom of the frame body (1) is fixedly connected to the roller (19).
2. The small-scale swing reactor according to claim 1, characterized in that, The drive shaft body (5) is made of a smooth round lead screw, and the surface of the drive shaft body (5) is coated with chrome plating.
3. A small swing reactor according to claim 1, characterized in that, The drive shaft bracket (6) is made of stainless steel 304.
4. A small swing reactor according to claim 1, characterized in that, The first fixing hole (10) and the second fixing hole (12) of the swing bracket are through holes used to fix the swing bracket body (7).
5. A small swing reactor according to claim 1, characterized in that, The coupling body (4) is used to connect the drive shaft body (5) and the stepper motor (3).
6. A small swing reactor according to claim 1, characterized in that, The upper fixing hole (9) and the lower fixing hole (8) of the swing bracket are both provided with threads. The positions of the first fixing hole (10) and the mounting hole (13) of the swing bracket correspond to the upper fixing hole (9) and the lower fixing hole (8) of the swing bracket, respectively.
7. A small swing reactor according to claim 1, characterized in that, The upper flange mounting holes (16) and the lower flange mounting holes (14) are each provided in four sets at equal intervals, and the upper flange body (15) and the lower flange body (11) are tightly fitted together.
8. A small swing reactor according to claim 1, characterized in that, The frame support (2) is made of stainless steel 304 and welded to the left and right sides of the frame body (1).