Liquid medicine bottle, pre-filling syringe and pre-filling clamping type bottle

Abstract

When the liquid medicine bottle is used, liquid medicine is arranged in a bottle body and needs to be discharged from a protruding part of the bottle body, air in the bottle body can stay in a remaining area along with the discharging of the liquid medicine, namely, an operator does not need to conduct exhaust operation during injection, air cannot enter a human body, and if redundant liquid medicine exists, the liquid medicine can be discharged out of the bottle body. The volume of the bottle body except for the indwelling area is the injection volume of the liquid medicine, so that the accuracy of the administration dosage is improved. The utility model further discloses a pre-filling and sealing injector and a pre-filling and sealing clamping type bottle.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a medicine bottle, a pre-filled syringe, and a pre-filled cartridge bottle. Background Technology

[0002] Pre-filled syringes are a form of pharmaceutical packaging that, through widespread use, has played a significant role in preventing the spread of infectious diseases and advancing the medical field. Pre-filled syringes are primarily used for packaging and storing high-end medications for direct injection or for surgical irrigation in ophthalmology, otology, orthopedics, and other procedures. Pharmaceutical manufacturers can pre-fill syringes with a measured quantity of medication. In clinical use, the syringe cap is removed for immediate administration. Applications include cosmetic procedures, vaccines, and insulin injections, and they are used for subcutaneous, intramuscular, and intravenous injections. This method avoids the secondary contamination and inaccurate dosage issues associated with traditional ampoules and vials. Pre-filled cartridges offer similar advantages.

[0003] Currently, pharmaceutical companies typically use pre-filled syringes to fill medications. This is done through direct filling, where the manufacturer fills the syringe with the medication after assembling the needle cap, then assembles the piston, seals and inspects it before shipping. This filling method inevitably results in a small amount of air bubbles remaining inside the pre-filled syringe.

[0004] Currently, pre-filled syringes (including pre-filled cartridges) on the market require an initial air purging procedure before clinical use to remove the gas from the syringe before injection. This process results in the loss of some medication. While this avoids injecting gas into the body, it also leads to inaccurate dosage, often resulting in a lower than normal dose.

[0005] Therefore, improving the accuracy of drug dosage is a technical problem that needs to be solved by those skilled in the art. Utility Model Content

[0006] In view of this, the first objective of this utility model is to provide a medicine bottle to improve the accuracy of drug dosage;

[0007] The second objective of this invention is to provide a pre-filled syringe;

[0008] The third objective of this invention is to provide a pre-filled cartridge bottle.

[0009] To achieve the first objective mentioned above, this utility model provides the following technical solution:

[0010] A medicine bottle includes a bottle body, the first end of which is a protrusion recessed into the interior of the bottle body along its own axis, and a retention area for retaining gas is formed between the protrusion and the inner wall of the bottle body.

[0011] Optionally, in the above-mentioned medicine bottle, the medicine bottle also includes a propulsion component, the outer diameter of which is equal to the inner diameter of the bottle body, and the outer wall of the propulsion component fits against the inner wall of the bottle body. A cavity for placing the medicine is formed between the propulsion component and the bottle body, and the cavity is connected to the retention area.

[0012] Optionally, in the aforementioned medicine bottle, the shape of the first end of the protrusion is adapted to the shape of the first end of the propeller.

[0013] Optionally, in the above-mentioned medicine bottle, the first end of the protrusion is V-shaped, and the first end of the pusher is V-shaped.

[0014] Optionally, in the aforementioned medicine bottle, the first end of the pusher includes a groove and a retaining platform. When the pusher engages with the protrusion, the retaining platform fits into the protrusion, and the groove communicates with the retention area.

[0015] Optionally, in the above-mentioned medicine bottle, the bottom of the groove is an inclined plane.

[0016] Optionally, in the aforementioned medicine bottle, the propellant is a piston.

[0017] The medicine bottle provided by this utility model contains medicine inside the bottle, and the medicine needs to be discharged from the protrusion of the bottle. As the medicine is discharged, the air inside the bottle will remain in the retention area. That is, the operator does not need to perform air venting during injection, and the gas will not enter the human body. If there is excess medicine, the excess medicine will also remain in the retention area, which can prevent air from entering the human body. The volume of the bottle excluding the retention area is the injection volume of the medicine, thereby improving the accuracy of the drug dosage.

[0018] To achieve the second objective mentioned above, this utility model provides the following technical solution:

[0019] A pre-filled syringe includes a liquid bottle as described above and a plunger, the plunger being inserted into the second end of the liquid bottle for dispensing liquid from inside the liquid bottle.

[0020] Optionally, in the pre-filled syringe described above, the pre-filled syringe further includes a needle and a needle cap. The needle is connected to the second end of the protrusion of the liquid bottle for discharging the liquid inside the liquid bottle. The needle cap is engaged with the outside of the needle for sealing the needle.

[0021] The pre-filled syringe provided by this utility model has a plunger inserted into the body of the medicine bottle. As the operator gradually inserts the plunger into the bottle, the medicine inside the bottle is discharged from the protrusion until the plunger abuts against the protrusion. Air and excess liquid inside the bottle are retained in the retention area. The operator can control the dosage by controlling the displacement of the plunger. When the displacement of the plunger is at its maximum, the dosage of the pre-filled syringe is a fixed value. This arrangement enables the pre-filled syringe to improve the accuracy of the dosage while preventing gas from entering the human body.

[0022] To achieve the third objective mentioned above, this utility model provides the following technical solution:

[0023] A pre-filled cartridge bottle includes a liquid bottle and a cap as described above, the cap being connected to a first end of the liquid bottle for sealing the liquid bottle.

[0024] The pre-filled cartridge bottle provided by this utility model has all the technical effects of the aforementioned liquid medicine bottle, and will not be repeated here. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0026] Figure 1 This is an overall structural diagram of the pre-filled syringe disclosed in an embodiment of the present utility model;

[0027] Figure 2 This is a detailed structural diagram of the pre-filled syringe disclosed in an embodiment of the present utility model;

[0028] Figure 3 This is a cross-sectional view of the pre-filled syringe disclosed in an embodiment of the present utility model;

[0029] Figure 4 This is a structural diagram of the propulsion component disclosed in an embodiment of the present utility model;

[0030] Figure 5 This is a structural diagram of the needle cap disclosed in an embodiment of the present utility model;

[0031] Figure 6 This is a structural diagram of the push rod disclosed in an embodiment of the present utility model;

[0032] Figure 7 This is a partial enlarged view of the pre-filled syringe disclosed in an embodiment of the present utility model;

[0033] Figure 8 This is another partially enlarged view of the pre-filled syringe disclosed in this embodiment of the present invention;

[0034] Figure 9 This is a diagram showing the position of air bubbles after horizontal injection, as disclosed in an embodiment of this utility model.

[0035] in:

[0036] Bottle body 100, protrusion 101, retention area 102, pusher 200, groove 201, clamping platform 202, push rod 300, needle 400, needle cap 500, first position 600, second position 601, third position 602, fourth position 603, fifth position 604, sixth position 605. Detailed Implementation

[0037] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without novelty are within the protection scope of the present utility model.

[0038] In the description of this utility model, it should be understood that the terms "upper," "lower," "top surface," "bottom surface," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the indicated position or element must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0039] Prefilled syringes, also known as pre-filled injectors, serve two purposes: storing medication and injecting it. After receiving the prefilled syringes, pharmaceutical companies fill the syringes with medication and assemble the pistons to achieve the function of storing medication.

[0040] Pre-filled cartridges are a new type of drug packaging that plays an important role in reducing the risk of drug contamination, improving injection efficiency, and reducing costs. They are usually used in conjunction with automated injection pens.

[0041] An automatic injection pen is a device for administering medication to a patient on a single basis. It automatically completes the injection after pressing the injection site. Since it cannot perform venting, a certain amount of gas will be injected into the body during injection.

[0042] The medicine bottle disclosed in this utility model includes a bottle body 100. The first end of the bottle body 100 has a protrusion 101 recessed into the interior of the bottle body 100 along its own axis. A retention area 102 for retaining gas is formed between the protrusion 101 and the inner wall of the bottle body 100. Specifically, the protrusion 101 is preferably located in the middle of the bottle body 100. When the first end of the bottle body 100 is vertically downward and the second end is vertically upward, the lowest position of the retention area 102 in the vertical direction should be lower than the highest position of the protrusion 101 in the vertical direction. It should be noted that the retention area 102 only refers to the area for retaining gas inside the bottle body 100 after the medicine is discharged; it, along with the cavity mentioned below, belongs to the internal space of the bottle body 100. The medicine bottle provided by this utility model contains medicine inside the bottle body 100 during use. The medicine needs to be discharged from the protrusion 101 of the bottle body 100. As the medicine is discharged, the air inside the bottle body 100 will remain in the retention area 102. If there is excess medicine, the excess medicine will also remain in the retention area 102, which can prevent air from entering the human body. The volume of the bottle body 100 excluding the retention area 102 is the injection volume of the medicine, thereby improving the accuracy of the drug dosage.

[0043] To optimize the above technical solution, the medicine bottle also includes a propulsion component 200. The outer diameter of the propulsion component 200 is equal to the inner diameter of the bottle body 100, and the outer wall of the propulsion component 200 is in contact with the inner wall of the bottle body 100. A cavity for placing the medicine is formed between the propulsion component 200 and the bottle body 100, and the cavity is connected to the retention area 102. Specifically, the propulsion component 200 can move along the axial direction of the bottle body 100. As the contact area between the propulsion component 200 and the bottle body 100 increases, the medicine inside the cavity is discharged from the protrusion 101. When the propulsion component 200 is in close contact with the protrusion 101, the original air bubbles inside the bottle body 100 and the excess medicine will be retained in the retention area 102, thereby completing the quantitative drug administration. Furthermore, the gas volume inside the bottle 100 should be smaller than the total volume of the retention area 102. This can be achieved by controlling the filling amount of the liquid when filling the bottle 100. This arrangement can avoid the situation where there is too much gas and the retention area 102 cannot accommodate it. Furthermore, the outer wall of the bottle 100 is provided with scale lines. The operator can fill the preset amount of liquid according to the scale lines so that when the pusher 200 is completely close to the protrusion 101, sufficient medication can be administered, thereby further improving the accuracy of the medication dosage.

[0044] To optimize the above technical solution, the shape of the first end of the protrusion 101 is adapted to the shape of the first end of the propeller 200. Specifically, the first end of the protrusion 101 is preferably conical, and the first end of the propeller 200 is also conical to match the first end of the protrusion 101. The ends of the first end of the protrusion 101 and the first end of the propeller 200 can be rounded or pointed. The first end of the protrusion 101 and the first end of the propeller 200 are preferably pointed to improve the fit between the protrusion 101 and the propeller 200. When the propeller 200 is in close contact with the protrusion 101, the first end of the protrusion 101 and the first end of the propeller 200 form a seal, preventing the flow of gas and liquid medicine, thereby improving the accuracy of the drug dosage.

[0045] To optimize the above technical solution, the first end of the protrusion 101 is V-shaped, and the first end of the pusher 200 is V-shaped. Specifically, the structure around the contact surface between the pusher 200 and the liquid medicine is mainly designed to accommodate air. When the first end of the protrusion 101 is V-shaped, the space of the retention area 102 is maximized, allowing the retention area 102 to accommodate more air bubbles from the original liquid medicine bottle, further preventing gas from entering the human body and improving the safety of the liquid medicine bottle.

[0046] To optimize the above technical solution, the first end of the pusher 200 includes a groove 201 and a retaining platform 202. When the pusher 200 engages with the protrusion 101, the retaining platform 202 fits against the protrusion 101, and the groove 201 communicates with the retention area 102. It should be noted that the "V-shaped" first end of the pusher 200 refers to the overall V-shaped shape of the first end, including the aforementioned groove 201 and retaining platform 202. Specifically, the retaining platform 202 is located in the middle of the first end of the pusher 200, with grooves 201 arranged on both sides. The space formed by the grooves 201 and the protrusion 101 is used to retain gas, further increasing the volume of gas that the liquid bottle can hold. This effectively prevents the retention area 102 from being unable to accommodate too many air bubbles, thus improving the safety of the liquid bottle. Simultaneously, increasing the volume of gas that the liquid bottle can hold eliminates the need for venting during injection, resulting in more precise dosage.

[0047] To optimize the above technical solution, the bottom of the groove 201 is an inclined plane. Specifically, the inclined bottom of the groove 201 can further increase the volume of gas that the bottle 100 can hold, thereby improving the safety of the medicine bottle and the accuracy of the dosage. It should be noted that the inclination of the bottom of the groove 201 can be adjusted according to production needs to adjust the volume of air bubbles that the bottle 100 can hold, and when filling the medicine, the volume of the medicine should be at least equal to the displacements s, π, and r generated by the pusher 200 moving from the initial position to the position abutting the protrusion 101.2 The product of r and the inner diameter of the bottle 100 is used to ensure that the amount of medicine injected from the initial position to the end position of the propulsion component 200 is quantitative, thereby achieving the accuracy of the drug dosage.

[0048] To optimize the above technical solution, the propellant 200 is a piston. In use, the piston is used to fit tightly against the bottle 100 to squeeze the liquid out of the bottle 100 from the protrusion 101.

[0049] like Figures 1-6 As shown, the pre-filled syringe disclosed in this utility model includes a liquid bottle as described in any of the above claims and a plunger 300. The plunger 300 is inserted into the second end of the liquid bottle for dispensing the liquid inside the bottle. Specifically, the plunger 300 is inserted into the second end of a piston. The first end of the plunger 300 is provided with a first insertion portion, and the second end of the piston is provided with a second insertion portion. When the plunger 300 cooperates with the piston, the first insertion portion and the second insertion portion are inserted into each other. The first insertion portion is either a plug or a socket, and the second insertion portion is either a plug or a socket. In use, the push rod 300 is inserted into the second end of the piston, and the piston is inserted into the bottle body 100 of the medicine bottle. As the operator gradually inserts the push rod 300 into the bottle body 100, the medicine inside the bottle body 100 is discharged from the protrusion 101 until the first end of the piston, the push rod 300, abuts against the protrusion 101. The air and excess liquid inside the bottle body 100 are retained in the retention area 102. The operator can control the dosage by controlling the displacement of the push rod 300. When the displacement of the push rod 300 is at its maximum, the dosage of the pre-filled syringe is a fixed value. This arrangement enables the pre-filled syringe to improve the accuracy of the dosage while preventing gas from entering the human body.

[0050] To optimize the above technical solution, the pre-filled syringe also includes a needle 400 and a needle cap 500. The needle 400 is connected to the second end of the protrusion 101 of the medicine bottle for discharging the medicine inside the medicine bottle. The needle cap 500 is engaged with the outside of the needle 400 to seal the needle 400. In use, the operator inserts the plunger 300 into the piston, disengages the needle cap 500 from the needle 400, and pushes the plunger 300 to administer the medication.

[0051] The pre-filled cartridge bottle disclosed in this utility model includes a liquid medicine bottle and a cap as described above. The cap is connected to the first end of the liquid medicine bottle for sealing the bottle. Specifically, the pre-filled cartridge bottle is usually used in conjunction with an automatic injection pen. The automatic injection pen does not have a venting function; it is pressed onto the skin for direct injection, and all the gas in the glass syringe is injected into the body. Using the aforementioned liquid medicine bottle can avoid the risks associated with gas injection.

[0052] The pre-filled cartridge bottle provided by this utility model has all the technical effects of the aforementioned liquid medicine bottle, and will not be repeated here.

[0053] The principle of this utility model will be described in detail below with reference to specific application scenarios:

[0054] like Figures 7-9 As shown, if there are air bubbles inside the medicine bottle after filling, when the bottle is inverted, the bubbles will be at position 1 (600), and position 2 (601) will be the liquid level. When the bottle is upright, the bubbles will be at position 3 (602), and position 4 (603) will be the liquid level. As the medicine is injected, the bubbles will remain at position 1 (600) or 3 (602). When the bottle is placed horizontally, the bubbles will adhere to the inner wall of the bottle 100, and as the medicine is injected, the bubbles will eventually be at position 5 (604), and position 6 (605) will be the liquid level after injection.

[0055] The advantages of this utility model are:

[0056] (1) Improved the accuracy of drug dosage;

[0057] (2) It can prevent gas from entering the human body during injection, and has high safety;

[0058] (3) Wide range of applications.

[0059] It should be noted that the medicine bottle, pre-filled syringe, and pre-filled cartridge provided by this utility model can be used in the field of medical device technology or other fields. Other fields refer to any field other than the field of medical device technology. The above are merely examples and do not limit the application areas of the medicine bottle, pre-filled syringe, and pre-filled cartridge provided by this utility model.

[0060] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other.

[0061] The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

[0062] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0063] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to any specific implementation. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A medicine bottle, characterized in that, It includes a bottle body and a propulsion component. The first end of the bottle body is a protrusion that is recessed into the interior of the bottle body along its own axis, and a retention area for retaining gas is formed between the protrusion and the inner wall of the bottle body. The outer diameter of the pusher is equal to the inner diameter of the bottle, and the outer wall of the pusher fits against the inner wall of the bottle. A cavity for placing the liquid medicine is formed between the pusher and the bottle, and the cavity is connected to the retention area. The shape of the first end of the protrusion is adapted to the shape of the first end of the propeller.

2. The medicine bottle as described in claim 1, characterized in that, The first end of the protrusion is V-shaped, and the first end of the pusher is V-shaped.

3. The medicine bottle as described in claim 1, characterized in that, The first end of the pusher includes a groove and a locking platform. When the pusher engages with the protrusion, the locking platform fits against the protrusion, and the groove communicates with the retention area.

4. The medicine bottle as described in claim 3, characterized in that, The bottom of the groove is an inclined plane.

5. The medicine bottle as described in claim 1, characterized in that, The propulsion component is a piston.

6. A pre-filled syringe, characterized in that, Includes a medicine bottle and a push rod as described in any one of claims 1-5, wherein the push rod is inserted into the second end of the medicine bottle for pushing out the medicine inside the medicine bottle.

7. The pre-filled syringe as described in claim 6, characterized in that, The pre-filled syringe also includes a needle and a needle cap. The needle is connected to the second end of the protrusion of the liquid bottle for discharging the liquid inside the liquid bottle. The needle cap is engaged with the outside of the needle for sealing the needle.

8. A pre-filled and sealed cartridge bottle, characterized in that, Includes a liquid medicine bottle and a bottle cap as described in any one of claims 1-5, wherein the bottle cap is connected to a first end of the liquid medicine bottle for sealing the liquid medicine bottle.

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