Ultrafiltration centrifugal inner tube

Abstract

The utility model relates to the technical field of centrifugal tubes, in particular to an ultrafiltration centrifugal inner tube which comprises an inner tube base body and a filter membrane, the inner pipe base body is provided with an inner cavity. The filtering membrane comprises a membrane base body, a welding part is arranged at the end part of the membrane base body, and the filtering membrane is welded on the inner wall of the inner cavity through the welding part; wherein the melting point of the membrane substrate is higher than that of the welding part. The air way design of the air suction way is used for generating vacuum suction force through negative pressure suction and fixing the filter membrane. And the welding temperature of the membrane can enable the welding part to be melted to be adhered to the inner pipe base body through heat conduction of the conduction part. According to the utility model, the integrated structure of the filter membrane ensures the centrifugal strength and can bear larger centrifugal force. The components are fewer, a plurality of components do not need to be matched and assembled, and meanwhile, the reliable filtering performance of the filtering membrane can be met. The circulation channel is designed as a welding piece heat exchange flow channel, and the production efficiency is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to centrifugal tube technical field, specifically is a kind of ultrafiltration centrifugal inner tube. BACKGROUND

[0002] Ultrafiltration centrifugal tube includes inner tube and outer tube, inner tube is loaded liquid, is placed in centrifuge, and liquid in inner tube is thrown out by centrifugal force, and the purpose of interception and concentration is achieved by filtering through filter membrane. Outer tube is used to collect the purpose of filtered solution.

[0003] The production process of ultrafiltration centrifugal tube has the following existing methods in the industry: first, the membrane is pre-welded on the filter sheet, and is fixed by ultrasonic welding or other methods. The advantage of this method is that the tube is a whole, with very high strength, and can withstand a large centrifugal force. Without welding, it avoids the situation of liquid leakage caused by rupture of the welding due to excessive centrifugal force.

[0004] Second, the membrane is pasted on the structure frame with glue, and a supporting structure is used to press against the membrane to achieve the sealing effect. The defect of this method is that the centrifugal force is outward, and the membrane may leak under the action of centrifugal force.

[0005] Third, the rubber elastomer is deformed to press the membrane to prevent liquid leakage. The rubber elastomer is made slightly smaller than the membrane, and the sealing purpose is achieved by the cooperation of the two structures and the deformation of the rubber elasticity. The disadvantage is that the structure is complex, and rubber is involved, which introduces the third substance. INVENTION CONTENTS

[0006] The purpose of the utility model is to provide an ultrafiltration centrifugal inner tube to solve the problems raised in the background art.

[0007] To achieve the above purpose, the utility model provides the following technical scheme:

[0008] An ultrafiltration centrifugal inner tube includes an inner tube base and a filter membrane.

[0009] The inner tube base has an inner cavity.

[0010] The filter membrane includes a membrane base, and has a welding portion at the end of the membrane base. The filter membrane is welded to the inner wall of the inner cavity through the welding portion.

[0011] The melting point of the membrane base is higher than that of the welding portion.

[0012] Preferably, the end of the membrane base has a conductive portion connected to the welding portion, and the conductive portion does not contact the inner wall of the inner cavity.

[0013] Preferably, the melting point of the conductive portion is higher than that of the welding portion, and the melting point of the conductive portion is lower than that of the membrane base.

[0014] Preferably, the welding part is flush with the membrane base or protrudes out of the membrane base.

[0015] Preferably, the inner wall of the inner cavity has an open flow channel, the bottom of the inner tube base has a flow guide hole in communication with the bottom of the flow channel, and the filter membrane is used to cover the opening of the flow channel and the flow guide hole.

[0016] Preferably, the melting point of the membrane base is 160-220 DEG C, the melting point of the conducting part is 160-190 DEG C, the melting point of the welding part is 150-180 DEG C, and the welding temperature of the welding sheet is 150-190 DEG C.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] The utility model discloses: the structure of filter membrane integrated molding guarantees centrifugal strength, can bear greater centrifugal force. Fewer components, do not need multiple components to assemble, can meet filter membrane reliable filtering performance simultaneously. The circulation channel is designed as the welding sheet heat exchange flow channel, and the production efficiency is improved. BRIEF DESCRIPTION OF DRAWINGS

[0019] In order to more clearly illustrate the technical scheme of the embodiment of the utility model, the drawings needed in the embodiment description will be briefly introduced as follows, and obviously, the drawings in the following description are only some embodiments of the utility model, and for ordinary skilled in the art, other drawings can be obtained according to these drawings without creating creative labor.

[0020] Figure 1 It is the structural schematic diagram of the utility model.

[0021] Figure 2 It is the utility model Figure 1 It is the section view at A-A of the utility model.

[0022] Figure 3 It is the schematic diagram of the filter membrane of the utility model not welded to the inner wall of the inner cavity.

[0023] Figure 4 It is the front view of the filter membrane of the utility model.

[0024] Figure 5 It is the rear view of the filter membrane of the utility model.

[0025] Figure 6 It is the schematic diagram of the filter membrane and the conducting part of the utility model being pasted on the welding sheet.

[0026] Figure 7 It is the structural schematic diagram of the utility model that the inner tube bottom end is inserted into the outer tube.

[0027] In the figure: 1 - inner tube base, 2 - inner cavity, 3 - filter membrane, 4 - flow guide hole, 5 - flow channel, 6 - opening, 7 - membrane base, 8 - conducting part, 9 - welding part, 10 - welding piece, 11 - vacuumizing cavity, 12 - air outlet, 13 - outer tube, 14 - plug. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present application will be clearly and completely described with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. The description of the at least one exemplary embodiment is actually only illustrative, but not as any limitation on the present application and its application or use. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of the present application.

[0029] It should be noted that the terms used herein are only intended to describe specific embodiments, and are not intended to limit the exemplary embodiments according to the present application. As used herein, the singular form is intended to include the plural form unless the context clearly indicates otherwise, and it should be understood that when the terms "comprise" and / or "include" are used in the specification, there is a feature, step, operation, device, component and / or combination thereof.

[0030] Unless specifically stated otherwise, the relative arrangement of components and steps, numerical expressions, and numerical values set forth in the various embodiments described herein are not limiting. It should be understood that the various parts shown in the drawings are not necessarily drawn to scale in proportion. The technology, methods and devices known to those skilled in the relevant art can not be discussed in detail, but should be considered as part of the authorized description. In all examples shown and discussed herein, any specific value should be interpreted as merely exemplary, and not as a limitation. Therefore, other examples of exemplary embodiments can have different values. It should be noted that similar reference numbers and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further discussed in subsequent drawings.

[0031] In the description of this utility model, it should be understood that the directional terms such as "front, back, up, down, left, right", "horizontal, vertical, horizontal" and "top, bottom" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description. Unless otherwise stated, these directional terms do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this utility model. The directional terms "inner" and "outer" refer to the inner and outer contours of each component itself.

[0032] For ease of description, spatial relative terms such as "above," "on top of," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation beyond the orientation of the device as described in the figures. For example, if the device in the figures were inverted, a device described as "above" or "on top of" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein will be interpreted accordingly.

[0033] Furthermore, it should be noted that the use of terms such as "first" and "second" to define components is merely for the purpose of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore cannot be construed as limiting the scope of protection of this utility model.

[0034] Please see Figures 1 to 7 This utility model provides a technical solution:

[0035] An ultrafiltration centrifuge inner tube is inserted into an outer tube 13, which can be used in conjunction with the outer tube 1 to form an ultrafiltration centrifuge tube. This ultrafiltration centrifuge tube can be used in a centrifuge to separate biological substances such as antibodies, enzymes, nucleic acids and proteins for the purpose of concentration, desalting, purification and fractionation, such as the separation and collection of concentrated substances such as urine, serum, plasma and cerebrospinal fluid (hereinafter specifically described as concentrated liquids). After the inner tube is inserted into the outer tube 13, the plug 13 connected to the opening at the top of the outer tube 1 covers the outer tube 14, thereby achieving the sealing of the ultrafiltration centrifuge tube.

[0036] The following is a detailed introduction:

[0037] An ultrafiltration centrifuge inner tube includes an inner tube substrate 1 and a filter membrane 3;

[0038] The inner tube base 1 has an inner cavity 2;

[0039] The filter membrane 3 includes a membrane substrate 7, and has a welding part 9 at the end of the membrane substrate 7. The filter membrane 3 is welded to the inner wall of the inner cavity 2 through the welding part 9.

[0040] The melting point of the film substrate 7 is higher than that of the welding part 9.

[0041] In one specific embodiment, such as Figure 6 As shown, a conductive portion 8, which is connected to the welding portion 9, is located at the end of the membrane substrate 7. The conductive portion 8 does not contact the inner wall of the inner cavity 2. The melting point of the conductive portion 8 is higher than that of the welding portion 9, and lower than that of the membrane substrate 7. The welding portion 9 is flush with or protrudes beyond the membrane substrate 7.

[0042] In one specific embodiment, such as Figure 2 and Figure 3 As shown, the inner wall of the inner cavity 2 has a flow channel 5 with an opening 6, the bottom of the inner tube base 1 has a guide hole 4 communicating with the bottom of the flow channel 5, and the filter membrane 3 is used to cover the opening 6 of the flow channel 5 and the guide hole 4.

[0043] In one specific embodiment, the melting point of the film substrate 7 is at...

[0044] The melting point of the conductive part (8) is 160℃~220℃, the melting point of the welding part (9) is 150℃~180℃, and the welding temperature of the welding piece (10) is 150℃~190℃.

[0045] A method for assembling an inner tube of an ultrafiltration centrifuge, comprising:

[0046] The conductive part 8 is attached to the welding piece 10, and the vacuum chamber 11 is evacuated by the air extraction channel 12 to keep the vacuum chamber 11 in a vacuum state, so that the filter membrane 3 is adsorbed and fixed on the welding piece 10. When the vacuum chamber 11 is kept in a vacuum state, the vacuum pressure in the vacuum chamber 11 can be flexibly set according to the actual situation, as long as the filter membrane 3 can be adsorbed and fixed on the welding piece 10 well.

[0047] The welding piece 10 is heated, and the welding part 9 is melted by heat conduction through the conductive part 8.

[0048] The welding piece 10 and the filter membrane 3 adsorbed and fixed on the welding piece 10 are inserted into the inner cavity 2 together, so that the welding part 9 is attached to the inner wall of the inner cavity 2 and covers the opening 6 of the flow channel 5 and the guide hole 4.

[0049] The vacuum cavity 11 is removed from the vacuum state to the normal pressure state, so that the welding piece 10 is separated from the filter membrane 3 and is withdrawn from the inner cavity 2, and the welding of the filter membrane 3 and the inner tube base 1 is completed.

[0050] In a specific embodiment, as shown in the drawings, the conducting part 8 protrudes out of the membrane base 7, so that the conducting part 8, the membrane base 7 and the welding piece 10 form the vacuum cavity 11; and the welding piece 10 is reserved with the exhaust channel 12 for connecting the negative pressure device and communicating with the vacuum cavity 11. Figure 6 The welding piece 10 is reserved with the circulating channel (not shown in the drawings) for circulating and cooling the condensed water, and the circulating channel is independent of and does not communicate with the exhaust channel 12. The circulating channel has two interfaces, one for the liquid inlet and one for the liquid outlet.

[0051] The vacuum is formed in the following way: the conducting part 8 protrudes outwards, so that the conducting part 8, the membrane base 7 and the welding piece 10 form the vacuum cavity 11; and the welding piece 10 is reserved with the exhaust channel 12 for connecting the negative pressure device and communicating with the vacuum cavity 11.

[0052] In a specific embodiment, the material of the welding piece 10 is metal. The material of the membrane base 7 can be PES, the material of the conducting part 8 can be ABC, and the material of the welding part 9 can be plastic.

[0053] The filter membrane 3 and the conducting part 8 are attached to the welding piece 10, the negative pressure device / vacuum device is connected to the exhaust channel 12, so that the vacuum cavity 10 is under negative pressure, and the filter membrane 3 is adsorbed and fixed on the welding piece 10.

[0054] The welding piece 10 is heated, and when heated to a required welding temperature of 150-190 DEG C, the heat conduction of the conduction part 8 can heat the welding part 9, and the welding part 9 is melted, but the conduction part 8 (in a "semi-melting" state, relative to the melting of the welding part 9, and can also be said to be a softened state, and will not become a viscoelastic state or a viscous flow state) is not pasted together with the welding piece 10, and considering that the welding part 9 (and the film base 7) is welded to the inner wall of the inner tube base 1 (that is, the inner wall of the inner cavity 2), the welding piece 10 is separated from the filter membrane 3, so the melting point of the film base 7 needs to be higher than that of the conduction part 8, and the melting point of the conduction part 8 needs to be higher than that of the welding part 9, so that when welded through the welding piece 10, the conduction part 8 is in a semi-melting state, and is adsorbed and fixed on the welding piece 10 after vacuumizing, and will not be pasted on the welding piece 10, and is convenient for being separated from the filter membrane 3 after cooling, and the heat conduction of the conduction part 8 causes the welding part 9 to be melted, and after the welding part 9 is melted, is firmly pasted on the inner wall of the inner cavity 2, so that the film base 7 can be firmly welded on the inner wall of the inner cavity 2, and in the welding process, the welding temperature will not affect the film base 7, and the integrity of the filter membrane 3 and the filtering reliability are ensured.

[0055] The welding piece 10 is heated to 150 DEG C-190 DEG C, and the filter membrane 3 is pasted and fixed on the inner wall of the inner cavity 2 through the welding part 8.

[0056] The adsorption and fixation of the welding piece 10 and the filter membrane 3 are as follows: the negative pressure equipment / vacuumizing equipment is connected to the air exhaust channel 12, so that the negative pressure of the vacuumizing cavity 10 can be realized, the welding piece 10 and the filter membrane 3 are more firmly pasted,

[0057] After the filter membrane 3 is adsorbed and fixed on the welding piece 10, the welding piece 10 and the filter membrane 3 are stretched into the inner cavity 2, and the filter membrane 3 is close to the inner wall of the inner cavity 2 (the inner tube base 1), because the melting point of the welding part 9 side of the filter membrane 3 is lower, so the welding part 9 side of the filter membrane 3 is melted and adhered to the inner wall to complete the welding. After welding, the welding piece 10 is cooled by condensed water and separated from the filter membrane 3.

[0058] The utility model discloses, the conduction part 5 is as the outside of filter membrane, and a little bit is protruded outward (of course the welding part 9 is as the inside of filter membrane, and a little bit can also be protruded outward), that is, as Figure 6 Illustrated, a little bit is protruded to the right side of the film base 7, so that the negative pressure can be achieved when vacuumizing, and thus the adsorption can be conveniently completed. Therefore, the negative pressure is released after the welding is completed, the welding piece 10 can be removed, and the cold water cooling can avoid the welding piece causing a flaw detection danger, and the purpose of increasing the working efficiency is realized.

[0059] After the filter membrane 3 is welded on the inner wall of the inner cavity 2, the filter membrane 3 covers the opening 6 of the flow channel 5, sample (or sample solution) enters the inner cavity 2 from the sample inlet opening of the inner tube 2, and passes through the filter membrane 3 to form filtered solution, the filtered solution can enter the flow channel 5 from the opening 6 and be discharged from the bottom guide hole 4, and the unfiltered sample solution is collected.

[0060] In general, the welding sheet 10 is made of metal material as a whole, good thermal conductivity is ensured, and a certain strength is provided. In a specific embodiment, the welding sheet 10 is made of pure copper material. The air channel of the air extraction channel 12 is designed to extract negative pressure to generate vacuum suction force to fix the filter membrane 3. The welding sheet 10 is used as a heating unit for overall heating, and the welding temperature of the membrane is between 150 DEG C and 190 DEG C. Through the negative pressure of the air extraction channel 12, a certain pressure is applied to the filter membrane 3 so that the membrane can be firmly adsorbed on the welding sheet 10 during welding. The circulating channel is connected to the condensed water for rapid cooling of the welding sheet 10, facilitating the welding of the next membrane. The advantages are that the filter membrane 3 is a plastic component as a whole, the original structure is not damaged, and welding is performed in the narrow inner cavity 2 space. The water cooling structure ensures the efficiency of welding, and the next membrane can be rapidly cooled and welded.

[0061] The filter membrane 3 is integrally formed, the structure ensures the centrifugal strength, can withstand greater centrifugal force, fewer components are needed, multiple components are not needed to be assembled, and the reliable filtering performance of the filter membrane can be met. The circulating channel is designed as a heat exchange flow channel of the welding sheet 10, and the production efficiency is improved.

[0062] Compared with the prior art of using glue to paste the membrane on the pipe wall, the sealing performance is better, and the risk of leakage can be reduced. Compared with the prior art of relying on the deformation of the rubber elasticity to achieve the purpose of membrane sealing, the structure is more simplified, and the risk of unnecessary substances being introduced into the filter membrane and the ultrafiltration centrifugal inner tube can be eliminated.

[0063] The utility model discloses, the part not described is prior art.

[0064] The above is only a preferred specific embodiment of the utility model, but the protection scope of the utility model is not limited to this, any skilled person in the art can make equivalent replacement or change according to the technical scheme and the utility model concept of the utility model within the technical range disclosed by the utility model, and all should be covered in the protection scope of the utility model.

Claims

1. An ultrafiltration centrifuge inner tube, characterized in that, The inner tube base (1) has an inner cavity (2); The filter membrane (3) comprises a membrane base (7) having a welding portion (9) at the end of the membrane base (7), and the filter membrane (3) is welded to the inner wall of the inner cavity (2) through the welding portion (9). The melting point of the membrane base (7) is higher than that of the welding portion (9). The end of the membrane base (7) has a conducting portion (8) connected with the welding portion (9), and the conducting portion (8) is not in contact with the inner wall of the inner cavity (2).

2. An ultrafiltration centrifuge inner tube according to claim 1, characterized in that The melting point of the conducting portion (8) is higher than that of the welding portion (9), and the melting point of the conducting portion (8) is lower than that of the membrane base (7).

3. An ultrafiltration centrifuge inner tube according to claim 2, wherein The welding portion (9) is flush with the membrane base (7) or protrudes outward from the membrane base (7).

4. An ultrafiltration centrifuge inner tube according to any one of claims 2 or 3, characterized in that The inner wall of the inner cavity (2) has a flow channel (5) with an opening (6), the bottom of the inner tube base (1) has a flow guide hole (4) in communication with the bottom of the flow channel (5), and the filter membrane (3) is used to cover the opening (6) of the flow channel (5) and the flow guide hole (4).

5. The ultrafiltration centrifugal inner tube according to claim 1, characterized in that, The melting point of the membrane base (7) is 160-220℃, the melting point of the conducting portion (8) is 160-190℃, the melting point of the welding portion (9) is 150-180℃, and the welding temperature of the welding sheet (10) is 150-190℃.

6. An ultrafiltration centrifuge inner tube according to claim 2, wherein ​

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