Chip clamp and nano-drug preparation system

Abstract

The utility model discloses a chip clamp and a nano-drug preparation system. The chip clamp comprises a main body part and an auxiliary connecting part, the main body part comprises a rotating plate, an overturning handle and supports arranged on the two sides of the rotating plate, the rotating plate is fixedly connected with the overturning handle, a clamping groove used for inserting a chip is formed between the rotating plate and the overturning handle, and the rotating plate is rotationally connected with the supports; and the auxiliary connecting component connects all the components of the main body component together. According to the chip clamp, a stable supporting structure is jointly formed by the rotating plate, the overturning handle, the support and the auxiliary connecting part, a fixing platform is provided for a chip, meanwhile, the accuracy of the position of the chip is ensured, and the chip is more convenient and faster to assemble and disassemble; the stability of the whole clamp structure is enhanced by using the auxiliary connecting part, the clamp is easy to clean and maintain, the sanitation and the performance of the clamp can be kept, and the service life of the clamp is prolonged.

Description

Technical Field

[0001] This utility model relates to the field of microfluidics, and in particular to a chip fixture and nanomedicine preparation system. Background Technology

[0002] In the field of nanomedicine preparation, chip technology is increasingly widely used, and its core component—the chip—plays a crucial role in the synthesis of drug formulations. The microfluidic channels within the chip provide a precisely controlled reaction environment for drug synthesis, enabling the efficient and controllable preparation of drug nanoparticles. Furthermore, the quality and yield of the produced samples directly reflect the performance of the nanomedicine preparation system. Therefore, ensuring the correct installation and stable operation of the chip is essential for the functionality of the entire system.

[0003] However, existing chip clamping devices have some limitations in practical applications. First, the operation of these devices is often complex, involving the coordinated operation of multiple mechanical components, which not only increases the difficulty of operation but also raises the risk of errors. Second, due to the complexity of their structural design, these clamps also face challenges in cleaning and maintenance, easily accumulating residues that can affect the purity and reproducibility of drug preparation. Furthermore, the complex structure makes maintenance and repair of the clamps cumbersome, increasing maintenance costs. Utility Model Content

[0004] The purpose of this invention is to provide a fixture and nanomedicine preparation system that is easy to operate, clean, and maintain, enabling accurate chip installation and normal operation under load.

[0005] To address the aforementioned technical problems, this utility model provides a chip fixture and a nanomedicine preparation system, wherein the chip fixture includes:

[0006] The main components include a rotating plate, a flip handle, and brackets disposed on both sides of the rotating plate. The rotating plate is fixedly connected to the flip handle, and a slot for inserting a chip is formed between the rotating plate and the flip handle. The rotating plate is rotatably connected to the brackets.

[0007] Auxiliary connecting components connect the various parts of the main body together.

[0008] Optionally, it also includes an information reading module; the rotating plate is provided with a notch, and the position of the information reading module corresponds to the notch.

[0009] Optionally, the auxiliary connecting component includes a rotating shaft bolt and a washer, the washer being located between the bracket and the rotating plate; the rotating plate has threaded holes of a fixed depth on both its left and right sides, and the brackets on both sides of the rotating plate have bracket through holes; the rotating shaft bolt passes through the bracket through holes and the washer and connects to the inner wall of the threaded holes of the fixed depth, and the rotating plate is rotatably connected to the bracket through the rotating shaft bolt.

[0010] Optionally, the auxiliary connecting component further includes a locking bolt, through which the rotating plate is fixedly connected to the flip handle.

[0011] Optionally, the auxiliary connection component further includes a first lateral limiting card and a second lateral limiting card installed between the rotating plate and the flip handle. The first lateral limiting card is located at the left end of the card slot, and the second lateral limiting card is located at the right end of the card slot. The first lateral limiting card and the second lateral limiting card cooperate with each other to restrict the lateral movement of the chip in the card slot.

[0012] Optionally, the auxiliary connection component further includes a locking piece, wherein the chip and the locking piece are arranged side by side in the slot, and the first lateral limiting card, the second lateral limiting card and the locking piece cooperate with each other to restrict the lateral movement of the chip in the slot.

[0013] Optionally, the chip has groove structures on both sides, and the second lateral limiting card and the card slot piece are both provided with elastic latches that cooperate with the groove structures. The card slot piece is provided with a chamfer structure, and the first lateral limiting card is provided with an elastic latch that cooperates with the chamfer structure.

[0014] Optionally, the rotating plate is further provided with a threaded through hole penetrating its upper and lower end faces, the positioning piece is further provided with a recessed structure, and the auxiliary connecting component further includes a ball bearing screw; one end of the ball bearing screw passes through the threaded through hole and is inserted into the recessed structure to realize the positioning piece in the slot.

[0015] A nanomedicine preparation system includes: a housing, a heating and heat preservation device, and a chip clamp; the heating and heat preservation device and the chip clamp are both mounted on the same mounting surface of the housing, and the flip handle of the chip clamp is positioned opposite to the heating and heat preservation device.

[0016] Optionally, the flip handle is provided with multiple magnets, which are used to achieve a detachable connection between the flip handle and the heating and heat preservation device; the heating and heat preservation device is provided with a number of syringe channels, and the distance between the rotation axis of the chip clamp and the mounting surface is greater than the distance between the central axis of the syringe channel and the mounting surface.

[0017] Compared with the prior art, the present invention has at least the following beneficial effects:

[0018] The chip clamp proposed in this utility model forms a stable support structure through a rotating plate, a flip handle, and a bracket. It provides a fixed platform for the chip while ensuring the chip's precise position and making chip loading and unloading more convenient and faster. The auxiliary connecting components firmly and precisely connect the various components of the main body together, enhancing the stability of the entire clamp structure. It also makes the clamp easy to clean and maintain, helps to maintain the clamp's hygiene and performance, and extends the clamp's service life.

[0019] Furthermore, the nanomedicine preparation system rationally arranges the chip fixture and heating and insulation device on the same mounting surface, forming a compact and functionally integrated preparation device. By flipping the handle and arranging the relative positions of the heating and insulation device, precise docking between the chip and the injection device is achieved, improving the reliability and efficiency of nanomedicine preparation. Attached Figure Description

[0020] Figure 1 This is an isometric view of a chip fixture in one embodiment of the present invention;

[0021] Figure 2 This is an isometric view of the chip clamp from another perspective in one embodiment of the present invention;

[0022] Figure 3 This is a rear view of the chip fixture in one embodiment of the present invention;

[0023] Figure 4 This is a schematic diagram of the structure of the flip handle in one embodiment of the present invention;

[0024] Figure 5 This is a schematic diagram of the chip clamp insertion slot piece in one embodiment of the present invention;

[0025] Figure 6 This is a schematic diagram of the chip clamp without the inserting slot piece in one embodiment of the present invention;

[0026] Figure 7 This is a partial structural schematic diagram of a nanomedicine preparation system in one embodiment of the present invention.

[0027] Reference numerals: 1. Rotating plate; 2. Flip handle; 3. Bracket; 4. Clearance notch; 5. Chip; 6. Information reading module; 7. Shaft bolt; 8. Washer; 9. Locking bolt; 10. Positioning piece; 11. First lateral limiter; 12. Second lateral limiter; 13. Recessed structure; 14. Vertical hole; 15. Magnet block; 16. Beaded set screw; 17. Heating and heat preservation device; 18. Syringe. Detailed Implementation

[0028] The chip fixture and nanomedicine preparation system of this utility model will be described in more detail below with reference to the schematic diagrams, which illustrate preferred embodiments of this utility model. It should be understood that those skilled in the art can modify the utility model described herein while still achieving the advantageous effects of this utility model. Therefore, the following description should be understood as being of general knowledge to those skilled in the art and is not intended to limit this utility model.

[0029] The present invention will be described in more detail below by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become clearer from the following description. It should be noted that the drawings are in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of the present invention.

[0030] like Figures 1 to 6 As shown, this embodiment of the present invention provides a chip fixture, comprising:

[0031] The main component includes a rotating plate 1, a flip handle 2, and brackets 3 disposed on both sides of the rotating plate 1. The rotating plate 1 is fixedly connected to the flip handle 2, and a slot for inserting a chip 5 is formed between the rotating plate 1 and the flip handle 2. The rotating plate 1 is rotatably connected to the brackets 3. The main component is used to place the chip 5, so that the chip 5 can automatically adapt to the working position after insertion without the need for secondary positioning operations.

[0032] The auxiliary connecting components connect the various parts of the main body together, ensuring the stability, accuracy, and ease of operation of the chip fixture.

[0033] The rotating plate 1 is made of metal, ensuring reliable installation of the chip 5 while maintaining the overall structural strength under load. The bracket 3, also made of metal, serves as the mounting reference for all components of the chip fixture and is one of the main components enabling the chip fixture to rotate.

[0034] In this embodiment, the chip fixture further includes an information reading module 6. A notch is provided on the rotating plate 1, and the information reading module 6 is positioned corresponding to the notch. The information reading module 6 scans the chip 5 exposed by the notch to detect the correct positioning of the chip 5 in the slot and reads the chip's tag information, which is typically a radio frequency identification (RFID) tag.

[0035] To ensure smooth rotation of the chip fixture's flip handle 2 and rotating plate 1, a certain distance is maintained between the information reading module 6 and the recessed bottom wall of the rotating plate 1. The rotating plate 1 also has an avoidance notch 4 to allow the information reading module 6 to pass during the flipping process, thus enabling a larger flipping angle for the chip fixture. Figure 1 As shown, the clearance notch 4 and the recess on the rotating plate 1 are located on opposite sides of the rotating plate 1 and are in opposite positions.

[0036] Specifically, the auxiliary connecting components include a pivot bolt 7 and a washer 8. The washer 8 is located between the bracket 3 and the rotating plate 1. The pivot bolt 7 and the washer 8 are used together to provide a fixed and appropriate resistance when the chip clamp rotates around the pivot bolt 7. The rotating plate 1 has threaded holes of a fixed depth on both its left and right sides, and the bracket 3 on both sides of the rotating plate has bracket through holes. The pivot bolt 7 passes through the bracket through holes and the washer 8 and connects to the inner wall of the threaded holes of the fixed depth. The rotating plate 1 is rotatably connected to the bracket 3 through the pivot bolt 7.

[0037] In one embodiment, the auxiliary connecting component further includes a locking bolt 9, through which the rotating plate 1 is fixedly connected to the flip handle 2. The rotating plate 1 is located above the flip handle 2, and the outer surface of the flip handle 2 has an L-shaped structure. The flip handle 2 is made of plastic, providing a certain degree of comfort while preventing heat transfer to the flip handle 2 when used with the heat preservation device and heat preservation sleeve of the nanomedicine preparation system. Furthermore, the flip handle 2 enables the rotating plate 1 to be flipped.

[0038] In this embodiment, the auxiliary connection component further includes a first lateral limiting card 11 and a second lateral limiting card 12 installed between the rotating plate 1 and the flip handle 2. The first lateral limiting card 11 is located at the left end of the card slot, and the second lateral limiting card 12 is located at the right end of the card slot. The first lateral limiting card 11 and the second lateral limiting card 12 cooperate with each other to restrict the lateral movement of the chip 5 in the card slot.

[0039] Furthermore, the auxiliary connecting component also includes a locking piece 10. The chip 5 and the locking piece 10 are arranged side by side in the slot. The first lateral limiting card 11, the second lateral limiting card 12, and the locking piece 10 cooperate with each other to restrict the lateral movement of the chip 5 in the slot. Nanomedicine preparation typically requires two sizes of chips 5. When using a dilution channel, three syringes 18 are usually provided, resulting in a relatively large chip 5 size. When not using a dilution channel, only two syringes 18 are needed, resulting in a smaller chip 5 size. The width of the slot is designed according to the size of the larger chip 5 used in the preparation process. When a smaller chip is inserted into the slot, the locking piece 10 can fill the gap for the smaller chip, working in conjunction with the first lateral limiting card 11 and the second lateral limiting card 12 to keep the lateral position of the smaller chip centered. The chip 5 is located below the information reading module 6, ensuring accurate reading of the chip 5's information. The formation of the slot ensures the correct placement of the chip 5 and the locking piece 10.

[0040] In one embodiment, the chip 5 has groove structures on both sides. The second lateral limiting card 12 and the carding piece 10 are both provided with elastic latches that cooperate with the groove structures. The carding piece 10 has a chamfered structure, and the first lateral limiting card 11 has an elastic latch that cooperates with the chamfered structure. The spring latches abut against the chip 5. Because the spring latches have a certain elasticity, when the dilution channel is not used, the chip 5 clamp can play a filling role, thereby centering the chip 5.

[0041] In one embodiment, the rotating plate 1 is further provided with a threaded through hole penetrating its upper and lower end faces, and the positioning piece 10 is further provided with a recessed structure 13. The auxiliary connecting component also includes a ball bearing set screw 16; one end of the ball bearing set screw 16 passes through the threaded through hole and is inserted into the recessed structure 13 to position the positioning piece 10 in the slot. The ball bearing set screw 16 provides longitudinal positioning for the positioning piece 10 and also facilitates the removal of the positioning piece 10 from the chip 5 fixture. When the chip 5 is correctly positioned, the syringe 18 connects with the fluid inlet of the chip 5, and pressure is applied to push the syringe 18, causing the reagent to flow from the fluid inlet into the microchannel of the chip 5. When the chip fixture is in use, because the lower part of the chip 5 is subjected to a vertically upward force, and the rotating shaft bolt 7 forms a 90° longitudinal shear force as the rotating shaft, the syringe 18 can be prevented from deviating from the vertical direction.

[0042] A nanomedicine preparation system, such as Figure 7As shown, the device includes a housing, a heating and heat preservation device 17, and the chip clamp. The heating and heat preservation device 17 and the chip clamp are both mounted on the same mounting surface of the housing, and the flip handle 2 of the chip clamp is positioned opposite to the heating and heat preservation device 17.

[0043] In the nanomedicine preparation system, the flip handle 2 has multiple vertical holes 14, which facilitates observation of the working status of the syringe 18 during the pushing process. Additionally, channel markers are provided near the multiple vertical holes 14 to facilitate the placement of the raw materials and reagents to be prepared into the designated channels.

[0044] In this embodiment, the flip handle 2 is made of plastic with poor thermal conductivity, which provides a certain degree of comfort while also preventing the heat from the heating and heat preservation device 17 from being conducted to the flip handle 2.

[0045] In this embodiment, the flip handle is provided with multiple magnet blocks 15, which are used to achieve a detachable connection between the flip handle 2 and the heating and heat preservation device 17. The heating and heat preservation device 17 is provided with a plurality of syringe 18 channels, and the distance between the rotation axis of the chip fixture and the mounting surface is greater than the distance between the central axis of the syringe 18 channel and the mounting surface. That is, when the syringe 18 is pushed upward, the rotating plate 1 rotates under force, and drives the flip handle 2 to squeeze the syringe 18 channel, preventing the position of the syringe 18 from shifting.

[0046] In this embodiment, the nanomedicine preparation system further includes a syringe driving device and a controller. The syringe driving device, the heating and heat preservation device, and the chip fixture information reading module are all electrically connected to the controller.

[0047] The nanomedicine preparation system rationally arranges the chip fixture and heating and insulation device on the same mounting surface, forming a compact and functionally integrated preparation device. By flipping the handle and arranging the relative positions of the heating and insulation device, precise docking between the chip and the injection device is achieved, improving the reliability and efficiency of nanomedicine preparation.

[0048] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A chip fixture, characterized in that, include: The main components include a rotating plate, a flip handle, and brackets disposed on both sides of the rotating plate. The rotating plate is fixedly connected to the flip handle, and a slot for inserting a chip is formed between the rotating plate and the flip handle. The rotating plate is rotatably connected to the brackets. Auxiliary connecting components connect the various parts of the main body together.

2. The chip fixture as described in claim 1, characterized in that, It also includes an information reading module; the rotating plate is provided with a notch, and the position of the information reading module corresponds to the notch.

3. The chip fixture as described in claim 1, characterized in that, The auxiliary connecting component includes a pivot bolt and a washer, with the washer located between the bracket and the rotating plate; The rotating plate has threaded holes of a fixed depth on both its left and right sides, and the brackets on both sides of the rotating plate have bracket through holes; the rotating shaft bolt passes through the bracket through hole and the washer and is connected to the inner wall of the threaded hole of the fixed depth, and the rotating plate is rotatably connected to the bracket through the rotating shaft bolt.

4. The chip fixture as described in claim 1, characterized in that, The auxiliary connecting component also includes a locking bolt, and the rotating plate is fixedly connected to the flip handle by the locking bolt.

5. The chip fixture as described in claim 1, characterized in that, The auxiliary connection component also includes a first lateral limiting card and a second lateral limiting card installed between the rotating plate and the flip handle. The first lateral limiting card is located at the left end of the card slot, and the second lateral limiting card is located at the right end of the card slot. The first lateral limiting card and the second lateral limiting card cooperate with each other to restrict the lateral movement of the chip in the card slot.

6. The chip fixture as described in claim 5, characterized in that, The auxiliary connection component also includes a locking piece. The chip and the locking piece are arranged side by side in the slot. The first lateral limiting card, the second lateral limiting card and the locking piece cooperate with each other to restrict the lateral movement of the chip in the slot.

7. The chip fixture as described in claim 6, characterized in that, The chip has groove structures on both sides, and the second lateral limiting card and the card slot piece are both provided with elastic latches that cooperate with the groove structures. The card slot piece is provided with a chamfer structure, and the first lateral limiting card is provided with an elastic latch that cooperates with the chamfer structure.

8. The chip fixture as described in claim 6, characterized in that, The rotating plate is also provided with a threaded through hole penetrating its upper and lower end faces, and the positioning piece is also provided with a recessed structure. The auxiliary connecting component also includes a ball bearing set screw. One end of the ball bearing set screw passes through the threaded through hole and is inserted into the recessed structure to realize the positioning piece in the slot.

9. A nanomedicine preparation system, characterized in that, include: Housing, heating and heat preservation device, and chip clamp as described in any one of claims 1 to 8; The heating and heat preservation device and the chip clamp are both mounted on the same mounting surface of the housing, and the flip handle of the chip clamp is opposite to the position of the heating and heat preservation device.

10. The nanomedicine preparation system according to claim 9, characterized in that, The flip handle is provided with multiple magnets, which are used to achieve a detachable connection between the flip handle and the heating and heat preservation device; the heating and heat preservation device is provided with a number of syringe channels, and the distance between the rotation axis of the chip clamp and the mounting surface is greater than the distance between the central axis of the syringe channel and the mounting surface.

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