Shaking-up device and polypeptide synthesis equipment

Abstract

The embodiment of the utility model provides a shaking device and polypeptide synthesis equipment. The shaking device comprises a motor assembly; the turntable is connected to the driving end of the motor assembly; the shaking-up plate is used for placing a part to be shaken up; the eccentric part is connected between the rotating disc and the shaking-up plate, the rotating disc can rotate under the driving of the motor assembly, the eccentric part is not coaxial with the rotating axis, and the eccentric part drives the shaking-up plate to swing in the first linear direction perpendicular to the rotating axis under the driving of the motor assembly. Under the driving of the motor assembly, the shaking plate and the to-be-shaken piece on the shaking plate only need to swing in the first linear direction. Compared with pendulum type swinging, the to-be-shaken-up piece only swings in one direction (namely the first linear direction), and therefore materials on the to-be-shaken-up piece are not prone to being thrown out. Therefore, the shaking device can reduce the possibility that the materials on the to-be-shaken piece are thrown out, the safety and the reliability of the shaking device are relatively high, and the reaction effect can be improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to polypeptide synthesis technical field, specifically, it relates to a shake even device and polypeptide synthesis equipment with same. BACKGROUND

[0002] As a key field of biological medicine innovation research and development, polypeptide synthesis technology has broad development prospects. With the advantages of high biological activity, high specificity, low side effects and difficulty in accumulation in the body, polypeptide drugs have become a hot spot in global new drug research and development. At present, more than 80 polypeptide drugs have been approved for marketing worldwide, with a market size of 62.8 billion US dollars in 2020, and it is expected to grow to 96 billion US dollars in 2025, showing strong growth momentum.

[0003] The traditional polypeptide synthesis scheme needs to put the resin into the reaction cup. The resin can be used as a solid carrier, which is usually pre-activated and has a protective group such as Fmoc (fluorenylmethoxycarbonyl). Then, a 20% piperidine solution can be added to the reaction cup, so that the resin can be deprotected, and then the Fmoc protective group at the N-terminal can be removed. Then, a gas such as nitrogen can be added to the reaction cup, so that bubbling (condensation reaction) can be carried out. In the above process, the shaking device drives the reaction cup to swing like a pendulum, so that the resin and the piperidine solution are in full contact, and thus the reaction speed can be improved.

[0004] However, during the swinging of the reaction cup, the piperidine solution and other substances in the reaction cup may be thrown out, causing pollution to the external components and poor reaction effect. In addition, the space occupied by the swinging of the reaction cup is large, and the applicability of the shaking device is poor. UTILITY MODEL CONTENTS

[0005] In order to at least partially solve the problems existing in the prior art, according to one aspect of the utility model, a shaking device is provided. The shaking device comprises: a motor assembly; a turntable connected to the driving end of the motor assembly; a shaking plate for placing the shaking object; and an eccentric member connected between the turntable and the shaking plate, wherein the turntable is rotatable under the drive of the motor assembly, the eccentric member is eccentric to the rotation axis, and the eccentric member drives the shaking plate to swing in a first linear direction perpendicular to the rotation axis under the drive of the motor assembly.

[0006] Exemplarily, the shaking device further comprises a connecting plate provided with a long slot extending in a second linear direction perpendicular to the rotation axis and the first linear direction, the eccentric member is inserted into the long slot and can swing in the long slot under the drive of the motor assembly, and the connecting plate is connected to the shaking plate.

[0007] Illustratively, the uniform-shaking device further comprises a guide rail assembly extending along the first linear direction, and the uniform-shaking plate is slidable along the guide rail assembly under the driving of the motor assembly.

[0008] Illustratively, the guide rail assembly comprises a first guide rail assembly and a second guide rail assembly, and the first guide rail assembly and the second guide rail assembly are located on two sides of the rotating disc along the first linear direction.

[0009] Illustratively, at least one of the first guide rail assembly and the second guide rail assembly comprises a connecting block, a plurality of guide rails and a plurality of sliding blocks, the plurality of guide rails extend along the first linear direction and are spaced along a second linear direction perpendicular to the rotation axis and the first linear direction, the plurality of sliding blocks are one-to-one corresponding and slidably connected to the plurality of guide rails, and the connecting block is connected between the plurality of sliding blocks and the uniform-shaking plate.

[0010] Illustratively, the eccentric member comprises a cam bearing follower, a mounting shaft of the cam bearing follower is connected to the rotating disc, and a roller of the cam bearing follower is connected to the uniform-shaking plate.

[0011] Illustratively, the motor assembly comprises a motor and a speed reducer, the speed reducer is connected between the motor and the rotating disc, and a driving end of the motor assembly is an output end of the speed reducer.

[0012] According to another aspect of the present application, a polypeptide synthesis device is also provided. The polypeptide synthesis device comprises any one of the uniform-shaking devices described above.

[0013] Illustratively, the polypeptide synthesis device further comprises a to-be-uniform-shaking member, at least one reaction cup is arranged on the to-be-uniform-shaking member, and the rotating disc is rotatable along the rotation axis under the driving of the motor assembly to drive the uniform-shaking plate and the reaction cup to swing along the first linear direction through the eccentric member.

[0014] Illustratively, the to-be-uniform-shaking member is further provided with an opening and closing cover assembly, and the opening and closing cover assembly seals the opening of the reaction cup when the reaction cup swings along the first linear direction.

[0015] The uniform-shaking device provided by the embodiment of the present application only needs to swing along the first linear direction under the driving of the motor assembly. Compared with the pendulum swing, the to-be-uniform-shaking member only swings in one direction (i.e. the first linear direction), so that the material on the to-be-uniform-shaking member is not easy to be thrown out. In this way, the uniform-shaking device can reduce the possibility of the material on the to-be-uniform-shaking member being thrown out, and the safety and reliability of the uniform-shaking device are higher, and the reaction effect can be improved. Moreover, the uniform-shaking device occupies a smaller space, and the uniform-shaking device can be applied in a relatively small scene, so the applicability is higher.

[0016] A series of simplified forms are introduced in the utility model content, which will be further described in detail in the specific embodiment part. The utility model content part does not mean to try to limit the key features and necessary technical features of the claimed technical scheme, and more does not mean to try to determine the protection scope of the claimed technical scheme.

[0017] The advantages and features of the utility model will be described in detail below in combination with the drawings. BRIEF DESCRIPTION OF DRAWINGS

[0018] The following drawings of the utility model are hereby incorporated as part of the utility model for understanding the utility model. The embodiments of the utility model and the description thereof shown in the drawings are used to explain the principle of the utility model. In the drawings,

[0019] Figure 1 It is a perspective view of part structure of polypeptide synthesis equipment according to an exemplary embodiment of the utility model;

[0020] Figure 2 It is Figure 1 It is a perspective view of the shaking device shown in the drawings; and

[0021] Figure 3 It is Figure 2 It is an exploded view of the shaking device shown in the drawings.

[0022] Among them, the above drawings include the following reference signs:

[0023] 100, shaking device; 200, motor assembly; 210, motor; 220, speed reducer; 300, turntable; 400, shaking plate; 500, eccentric part; 510, mounting shaft; 520, roller; 600, connecting plate; 610, long slot; 700, guide rail assembly; 701, first guide rail assembly; 702, second guide rail assembly; 710, connecting block; 720, guide rail; 730, sliding block; 740, mounting plate; 741, through hole; 800, to be shaken part; 810, reaction cup; 811, opening; 820, opening and closing cover assembly. DETAILED DESCRIPTION

[0024] In the following description, a large number of details are provided so that the utility model can be thoroughly understood. However, those skilled in the art can understand that the following description only exemplarily shows the preferred embodiments of the utility model, and the utility model can be implemented without one or more such details. In addition, in order to avoid confusion with the utility model, some technical features known in the art are not described in detail.

[0025] According to one aspect of the present application, a kind of shaking device is provided.Shaking device can be placed on the to-be-shaken component for shaking.The shaking device can be applied to any suitable device, including but not limited to polypeptide synthesis equipment.Therefore, according to another aspect of the present application, a polypeptide synthesis equipment is also provided.The shaking device and polypeptide synthesis equipment of the present application embodiment will be described in detail below with reference to the drawings.

[0026] As shown in Figures 2-3 Shaking device 100 can include motor assembly 200, turntable 300, shaking plate 400 and eccentric component 500.

[0027] Motor assembly 200 can adopt various types of motor assemblies known in the art or may appear in the future, including but not limited to servo motor assembly or stepper motor assembly.Motor assembly 200 can be used as the power source of shaking device 100.

[0028] Turntable 300 can be connected to the driving end of motor assembly 200.Motor assembly 200 can provide power for turntable 300.Under the driving of motor assembly 200, turntable 300 can rotate around the rotation axis.Exemplarily, the rotation axis can be the axis of the driving end of motor assembly 200.

[0029] Shaking plate 400 can be used to place the to-be-shaken component 800.The to-be-shaken component 800 includes but is not limited to reaction cup or reagent bottle.The to-be-shaken component 800 can be seated on the shaking plate 400, or connected to the shaking plate 400 by welding, clamping or connecting piece, or any suitable connection method.

[0030] Eccentric component 500 can be connected between turntable 300 and shaking plate 400 by welding, clamping or connecting piece, or any suitable connection method.Eccentric component 500 can be eccentric to the rotation axis.That is, eccentric component 500 can be eccentrically arranged on turntable 300.Eccentric component 500 can adopt a protruding block, a long rod or any other suitable structure.

[0031] In actual application, the to-be-shaken component 800 can be placed on the shaking plate 400.Then, under the driving of motor assembly 200, turntable 300 can rotate around the rotation axis, so that the shaking plate 400 can be driven by eccentric component 500 to swing along the first straight line direction X-X.The first straight line direction X-X can be perpendicular to the direction of the rotation axis.In this way, the to-be-shaken component 800 placed on the shaking plate 400 can swing along the first straight line direction X-X.In the process of swinging, the material on the to-be-shaken component 800 can be shaken.

[0032] In summary, the shaker 100 provided by the embodiment of the present application only needs to swing along the first linear direction X-X under the driving of the motor assembly 200. Compared with the pendulum swing, the to-be-shaken object 800 only swings in one direction (i.e. the first linear direction X-X), so that the material on the to-be-shaken object 800 is not easy to be thrown out. In this way, the shaker 100 can reduce the possibility of the material on the to-be-shaken object 800 being thrown out, and the safety and reliability of the shaker 100 are higher, and the reaction effect can be improved. Moreover, the shaker 100 occupies a smaller space, and the shaker 100 can be applied in a relatively small scene, so that the applicability is higher.

[0033] As shown in Figures 2-3 exemplarily, the shaker 100 can further include a connecting plate 600. The connecting plate 600 can be provided with a long slot 610. The long slot 610 can extend along the second linear direction Y-Y. The second linear direction Y-Y can be perpendicular to the first linear direction X-X. Exemplarily, the direction of the rotation axis can be a vertical direction. The first linear direction X-X and the second linear direction Y-Y can be two horizontal directions perpendicular to each other. The eccentric member 500 can be inserted into the long slot 610. Moreover, under the driving of the motor assembly 200, the eccentric member 500 can rotate around the rotation axis, so as to swing in the long slot 610 along the second linear direction Y-Y. When the eccentric member 500 abuts against the slot wall of the long slot 610 along the second linear direction Y-Y, the eccentric member 500 can push the connecting plate 600 to swing along the first linear direction X-X, so as to drive the shaker plate 400 and the to-be-shaken object 800 thereon to swing along the first linear direction X-X. The connecting plate 600 can be connected to the shaker plate 400 by any suitable mode such as welding, clamping or connecting member connection.

[0034] As shown in Figures 2-3As shown, the eccentric member 500 can comprise a cam bearing follower. The cam bearing follower can comprise a mounting shaft 510 and a roller 520. The mounting shaft 510 can be connected to the rotating disc 300. The roller 520 can be directly or indirectly connected to the shaking plate 400. Specifically, one end of the mounting shaft 510 can be connected to the rotating disc 300. The roller 520 can be connected to the other end of the mounting shaft 510. The roller 520 of the cam bearing follower can rotate relative to the mounting shaft 510. In this way, the roller 520 of the cam bearing follower can realize rolling friction with the components connected thereto during rotation, thereby reducing the wear of the two, and thus improving the service life. In the embodiment in which the shaking device 100 comprises the connecting plate 600, the roller 520 of the cam bearing follower can be inserted into the long slot 610. In this way, the roller 520 of the cam bearing follower can swing in the long slot 610 along the second linear direction Y-Y. In this way, the roller 520 of the cam bearing follower can realize rolling friction with the long slot 610 during the swinging of the roller 520 of the cam bearing follower in the long slot 610 along the second linear direction Y-Y. Moreover, the eccentric member 500 can adopt a standard part, thereby eliminating the need for separate design, and reducing the design amount of the shaking device 100.

[0035] As shown, the shaking device 100 can further comprise a guide rail assembly 700. The guide rail assembly 700 can extend along the first linear direction X-X. The shaking plate 400 can be connected to the guide rail assembly 700. Under the driving of the motor assembly 200, the shaking plate 400 can slide along the guide rail assembly 700. By providing the guide rail assembly 700, the shaking plate 400 can be positioned, thereby enabling the shaking plate 400 to move only along the first linear direction X-X. Moreover, the guide rail assembly 700 can further improve the linearity and stability of the shaking plate 400 moving along the first linear direction X-X. Figures 2-3 As shown, the guide rail assembly 700 can comprise a first guide rail assembly 701 and a second guide rail assembly 702. Along the first linear direction X-X, the first guide rail assembly 701 and the second guide rail assembly 702 can be located on both sides of the rotating disc 300. The structures of the first guide rail assembly 701 and the second guide rail assembly 702 can be the same or different. The shaking plate 400 can be connected to the first guide rail assembly 701 and the second guide rail assembly 702. By providing the first guide rail assembly 701 and the second guide rail assembly 702, the positioning effect of the shaking plate 400 is better. Moreover, the first guide rail assembly 701 and the second guide rail assembly 702 can further improve the linearity and stability of the shaking plate 400 moving along the first linear direction X-X.

[0036] Figures 2-3 As shown, the guide rail assembly 700 can comprise a first guide rail assembly 701 and a second guide rail assembly 702. Along the first linear direction X-X, the first guide rail assembly 701 and the second guide rail assembly 702 can be located on both sides of the rotating disc 300. The structures of the first guide rail assembly 701 and the second guide rail assembly 702 can be the same or different. The shaking plate 400 can be connected to the first guide rail assembly 701 and the second guide rail assembly 702. By providing the first guide rail assembly 701 and the second guide rail assembly 702, the positioning effect of the shaking plate 400 is better. Moreover, the first guide rail assembly 701 and the second guide rail assembly 702 can further improve the linearity and stability of the shaking plate 400 moving along the first linear direction X-X.

[0037] As shown, the guide rail assembly 700 can comprise a first guide rail assembly 701 and a second guide rail assembly 702. Along the first linear direction X-X, the first guide rail assembly 701 and the second guide rail assembly 702 can be located on both sides of the rotating disc 300. The structures of the first guide rail assembly 701 and the second guide rail assembly 702 can be the same or different. The shaking plate 400 can be connected to the first guide rail assembly 701 and the second guide rail assembly 702. By providing the first guide rail assembly 701 and the second guide rail assembly 702, the positioning effect of the shaking plate 400 is better. Moreover, the first guide rail assembly 701 and the second guide rail assembly 702 can further improve the linearity and stability of the shaking plate 400 moving along the first linear direction X-X. Figures 2-3 ​As shown, at least one of the first guide rail assembly 701 and the second guide rail assembly 702 may include a connecting block 710, a plurality of guide rails 720, and a plurality of sliders 730. Exemplarily, each of the first guide rail assembly 701 and the second guide rail assembly 702 may include a connecting block 710, a plurality of guide rails 720, and a plurality of sliders 730. The plurality of guide rails 720 may extend along a first linear direction XX. Furthermore, the plurality of guide rails 720 may be spaced apart along a second linear direction YY. In the embodiment shown in the figure, two guide rails 720 may be included. The plurality of sliders 730 may be slidably connected to the plurality of guide rails 720 in a one-to-one correspondence. The connecting block 710 may connect between the plurality of sliders 730 and the shaking plate 400. By providing a plurality of guide rails 720, the limiting effect on the shaking plate 400, as well as the linearity and stability of the shaking plate 400 moving along the first linear direction XX, can be further improved.

[0038] For example, such as Figures 2-3 As shown, the shaking device 100 may further include a mounting plate 740. A guide rail assembly 700 may be disposed on the mounting plate 740. Specifically, a plurality of guide rails 720 may be disposed on the mounting plate 740. A through hole 741 may be provided on the mounting plate 740. The drive end of the motor assembly 200 may pass through the through hole 741, thereby connecting to the turntable 300. Along the direction of the rotation axis, the mounting plate 740 may isolate the main body of the motor assembly 200 from the shaking plate 400 and the material to be shaken 800 thereon, thereby preventing material on the material to be shaken 800 from falling onto the main body of the motor assembly 200.

[0039] For example, such as Figures 2-3 As shown, the motor assembly 200 may include a motor 210 and a reducer 220. The reducer 220 may be connected between the motor 210 and the turntable 300. Specifically, the drive shaft of the motor 210 may be connected to the input end of the reducer 220. The output end of the reducer 220 (i.e., the drive end of the motor assembly 200) may be connected to the turntable 300. Thus, driven by the motor 210, the reducer 220 can drive the turntable 300 to rotate around the rotation axis. The motor 210 may be any type of motor known in the art or that may appear in the future, including but not limited to servo motors or stepper motors. With this configuration, the motor assembly 200 has a simple structure and low manufacturing cost. Furthermore, by setting the reducer 220, the rotational speed of the turntable 300 can be adjusted, thereby adjusting the frequency of the shaking plate 400 and the shaken piece 800 on it swaying along the first linear direction XX, and thus adjusting the shaking effect. Furthermore, by setting the speed reducer 220, the output torque can be increased, thereby allowing a heavier piece to be shaken 800 to be placed on the shaking plate 400.

[0040] For example, such as Figure 1As shown in the embodiment where the shaking device 100 is applied to the polypeptide synthesis apparatus, the polypeptide synthesis apparatus can further include a to-be-shaken member 800. The to-be-shaken member 800 can be provided with at least one reaction cup 810. In the embodiment shown in the figure, the to-be-shaken member 800 can be provided with ten reaction cups 810. The ten reaction cups 810 can be arranged at intervals along the first straight line direction X-X. Under the driving of the motor assembly 200, the rotating disc 300 can rotate along the rotation axis to drive the shaking plate 400 and the reaction cup 810 to swing along the first straight line direction X-X through the eccentric member 500. In this way, the polypeptide synthesis apparatus can have the function of shaking, thereby facilitating the improvement of the effect of polypeptide reaction. For example, resin and piperidine solution can be added to the reaction cup 810. During the swinging of the reaction cup 810 along the first straight line direction X-X, the resin and piperidine solution can be in sufficient contact, thereby accelerating the reaction and achieving the purpose of improving the reaction speed. Different reactions can be carried out in different reaction cups 810. By providing a plurality of reaction cups 810, the throughput of the polypeptide synthesis apparatus for polypeptide synthesis can be improved.

[0041] For example, as shown in the embodiment of the polypeptide synthesis apparatus, Figure 1 The to-be-shaken member 800 can be further provided with an opening and closing cover assembly 820. When the reaction cup 810 swings along the first straight line direction X-X, the opening and closing cover assembly 820 can cover the opening 811 of the reaction cup 810. The opening 811 can be usually located at the top of the reaction cup 810. When the opening and closing cover assembly 820 uncovers the opening 811 of the reaction cup 810, resin and other materials can be placed into the reaction cup 810 through the opening 811, or taken out through the opening 811. By covering the opening 811 of the reaction cup 810 through the opening and closing cover assembly 820, the piperidine solution and other materials in the reaction cup 810 can be prevented from being thrown out during the swinging along the first straight line direction X-X. In this way, the safety and reliability of the polypeptide synthesis apparatus are better.

[0042] For example, as shown in the embodiment of the polypeptide synthesis apparatus, Figure 1 The polypeptide synthesis apparatus can further include a plurality of to-be-shaken members 800. Each to-be-shaken member 800 can include a plurality of reaction cups 810. The opening and closing cover assembly 820 can correspondingly cover the openings 811 of all the reaction cups 810 of the to-be-shaken member 800.

[0043] In the description of the utility model, it is understood that the orientation words such as "front", "rear", "upper", "lower", "left", "right", "transverse", "vertical", "perpendicular", "horizontal" and "top", "bottom" and the like indicated orientation or positional relationship is usually based on the orientation or positional relationship shown in the drawings, only for the convenience of describing the utility model and simplifying the description, in the absence of the opposite statement, these orientation words do not indicate and imply that the device or element indicated must have a particular orientation or be constructed and operated in a particular orientation, therefore can not be understood as the limitation of the protection scope of the utility model;The orientation words "inner", "outer" refer to the inner and outer of the contour of each component.

[0044] For the convenience of description, regional relative terms such as "on", "above", "upper surface", "upper" and the like can be used here to describe the regional position relationship of one or more components or features shown in the drawing with other components or features.It should be understood that the regional relative terms not only include the orientation of the components described in the drawing, but also include different orientations in use or operation.For example, if the components in the drawing are inverted as a whole, the components "above" or "on" other components or features will include the case of "below" or "under" other components or structures.Therefore, the exemplary term "above" can include both "above" and "below".In addition, these components or features can also be positioned at other different angles (for example, rotated by 90 degrees or other angles), and all these cases are intended to be included herein.

[0045] It should be noted that the terms used herein are only for the purpose of describing specific embodiments, and are not intended to limit the exemplary embodiments according to the present application.As used herein, the singular form is intended to include the plural form unless the context clearly indicates otherwise, and it should also be understood that when the terms "comprise" and / or "include" are used in the specification, it means that the features, steps, operations, components, assemblies and / or their combinations are present.

[0046] It should be noted that the terms "first", "second" and the like in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and do not necessarily describe a specific order or sequence of succession.It should be understood that the data used in this way can be interchanged under appropriate circumstances, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein.

[0047] The utility model discloses has been through the above embodiment has been explained, but should understand, the above embodiment is only for the purpose of example and illustration, and is not intended to limit the utility model to the range of described embodiment. In addition, those skilled in the art can understand that the utility model is not limited to the above embodiment, and more kinds of variations and modifications can be made according to the teaching of the utility model, and the variations and modifications all fall within the range of the utility model claimed. The protection scope of the utility model is defined by the attached claims and its equivalent range.

Claims

1. A shaking device, characterized in that, include: Motor assembly; A turntable connected to the drive end of the motor assembly; A shaking plate, wherein the shaking plate is used to place the parts to be shaken; as well as An eccentric component, wherein the eccentric component is connected between the turntable and the shaking plate, wherein The turntable is rotatable under the drive of the motor assembly. The eccentric component is not coaxial with the rotation axis of the turntable. Under the drive of the motor assembly, the eccentric component causes the shaking plate to swing along a first straight line direction perpendicular to the rotation axis.

2. The shaking device as described in claim 1, characterized in that, The shaking device further includes a connecting plate, on which a long groove is provided extending along a second straight direction perpendicular to the rotation axis and the first straight direction. The eccentric member is inserted into the long groove and can swing within the long groove under the drive of the motor assembly. The connecting plate is connected to the shaking plate.

3. The shaking device as described in claim 1, characterized in that, The shaking device further includes a guide rail assembly extending along the first straight line direction, and the shaking plate can slide along the guide rail assembly under the drive of the motor assembly.

4. The shaking device as described in claim 3, characterized in that, The guide rail assembly includes a first guide rail assembly and a second guide rail assembly, which are located on both sides of the turntable along the first straight line direction.

5. The shaking device as described in claim 4, characterized in that, At least one of the first guide rail assembly and the second guide rail assembly includes a connecting block, a plurality of guide rails and a plurality of sliders. The plurality of guide rails extend along the first straight line direction and are spaced apart along a second straight line direction perpendicular to the rotation axis and the first straight line direction. The plurality of sliders are slidably connected to the plurality of guide rails in a one-to-one correspondence. The connecting block is connected between the plurality of sliders and the shaking plate.

6. The shaking apparatus as described in claim 1, characterized in that, The eccentric component includes a cam bearing follower, the mounting shaft of which is connected to the turntable, and the roller of which is connected to the shaking plate.

7. The shaking apparatus as described in claim 1, characterized in that, The motor assembly includes a motor and a speed reducer, the speed reducer being connected between the motor and the turntable, and the drive end of the motor assembly being the output end of the speed reducer.

8. A polypeptide synthesis apparatus, characterized in that, Includes the shaking device as described in any one of claims 1-7.

9. The polypeptide synthesis apparatus as described in claim 8, characterized in that, The polypeptide synthesis device further includes a mixing element, on which at least one reaction cup is disposed. The turntable is rotatable along the rotation axis under the drive of the motor assembly, so as to drive the mixing plate and the reaction cup to swing along the first straight line direction through the eccentric component.

10. The polypeptide synthesis apparatus as described in claim 9, characterized in that, The shaker is also provided with an opening and closing lid assembly, which seals the opening of the reaction cup when the reaction cup is shaken along the first straight line direction.

Images