Flow-speed-adjustable mixing device for NK cell and medicine combined treatment

Abstract

The utility model relates to the technical field of NK (Natural Killer) cells, and provides an adjustable flow velocity mixing device for NK cell and medicine combined therapy, which comprises a mixing machine body, a discharge port is arranged at the bottom of the mixing machine body, an adjusting feeding component is arranged at the upper end of the mixing machine body and comprises a feeding cover, a rotating shaft is arranged in the feeding cover, and a flow velocity adjusting component is arranged at the lower end of the rotating shaft. One end of the rotating shaft extends out of the feeding cover, a rotating ball is arranged in the feeding cover, a plurality of liquid inlet grooves are formed in the side wall of the rotating ball, the liquid inlet grooves are evenly distributed in the rotating ball, one end of the rotating ball is fixedly connected with the rotating shaft, an output motor is arranged at one end of the rotating shaft, and a motor table is arranged at the bottom of the output motor. According to the technical scheme, the problems that in the prior art, feeding needs to be carried out before mixing and stirring, the feeding flow cannot be accurately metered in a common feeding mode, the feeding amount cannot be ensured in the feeding process, and consequently the proportion is wrong after mixing are solved.

Description

TECHNICAL FIELD

[0001] The utility model relates to NK cell technical field, specifically, it relates to the adjustable flow rate mixing device for the combined treatment of NK cell and medicine. BACKGROUND

[0002] NK cell is the important immune cell of organism, is not only related to antitumor, antiviral infection and immunoregulation, and participates in hypersensitivity and the occurrence of autoimmune disease under certain conditions, can identify target cell, killing medium, is derived from bone marrow lymphoid stem cell, and its differentiation, development depends on bone marrow and thymus microenvironment, is mainly distributed in bone marrow, peripheral blood, liver, spleen, lung and lymph node, NK cell is different from T, B cell, is a kind of lymphocyte that can non-specifically kill tumor cell and virus infection cell without prior sensitization.

[0003] There are the following problems in the mixing process of NK cell: 1, feeding is needed before mixing and stirring, and the commonly used feeding mode cannot accurately measure the flow of feeding; 2, the feeding amount cannot be ensured during feeding, which leads to the problem of wrong mixing ratio after mixing, in view of this, the adjustable flow rate mixing device for the combined treatment of NK cell and medicine is developed. UTILITY MODEL CONTENT

[0004] The utility model provides adjustable flow rate mixing device for the combined treatment of NK cell and medicine, solves the problem of prior art in mixing and stirring, feeding is needed, and the commonly used feeding mode cannot accurately measure the flow of feeding, the feeding amount cannot be ensured during feeding, which leads to the problem of wrong mixing ratio after mixing.

[0005] The technical scheme of the utility model is as follows: including

[0006] The mixing machine body is provided with a discharge port at the bottom;

[0007] The adjustable feeding assembly is arranged at the upper end of the mixing machine body;

[0008] The feeding filter assembly is arranged at the top of the mixing machine body;

[0009] The adjustable feeding assembly includes a feeding cover, a rotating shaft is arranged in the feeding cover, one end of the rotating shaft extends out of the feeding cover, a rotating ball is arranged in the feeding cover, a liquid inlet groove is arranged on the side wall of the rotating ball, the number of the liquid inlet grooves is several, and the plurality of liquid inlet grooves are evenly distributed on the rotating ball, one end of the rotating ball is fixedly connected with the rotating shaft, an output motor is arranged at one end of the rotating shaft, and a motor table is arranged at the bottom of the output motor.

[0010] As a further technical scheme, the motor table is arranged at the upper end of the mixing machine body, one end of the rotating ball is provided with a limiting shaft, a limiting ball is arranged on the limiting shaft, and the limiting ball is embedded in the sidewall of the feeding cover.

[0011] As a further technical scheme, the feeding filter assembly comprises a convex piece, the convex piece is fixedly embedded in the feeding cover, a feeding opening is formed at the edge of the convex piece, a filter conical net is arranged in the feeding cover, the filter conical net is located at the lower end of the convex piece, and a filter net pipe is arranged on the filter conical net.

[0012] As a further technical scheme, the filter conical net is located above the rotating ball, a through hole is formed at the center of the filter conical net, and the filter net pipe is arranged on the through hole.

[0013] As a further technical scheme, the upper end of the feeding cover is provided with a wide-mouth collecting cover, and the wide-mouth collecting cover is in communication with the feeding cover.

[0014] As a further technical scheme, the wide-mouth collecting cover is provided with a buckle plate, the buckle plate is provided with a buckle slot, and a sealing table is arranged in the buckle slot.

[0015] As a further technical scheme, the buckle plate is provided with a bending strip, a bending accommodation slot is formed in the sidewall of the bending strip, and a plurality of bending accommodation slots are equidistantly arranged on the bending strip.

[0016] As a further technical scheme, the rotating ball is sealingly embedded between the feeding cover, and the structure of the rotating ball is matched with the structure of the feeding cover.

[0017] As a further technical scheme, the bottom of the mixing machine body is provided with a plurality of supporting legs, and the plurality of supporting legs are uniformly distributed on the bottom surface of the mixing machine body.

[0018] As a further technical scheme, the bottom of the output motor is provided with a motor base, and the motor table and the motor base are fixedly installed.

[0019] The working principle and beneficial effects of the utility model are as follows:

[0020] The utility model discloses realize following effect: 1, the liquid in the liquid inlet groove when rotating ball rotates will bring into the bottom of feed cover, thereby flow into the inside of mixing machine body, because the capacity of liquid inlet groove is fixed, therefore can obtain the dosage of liquid inlet through the number of rotation; 2, through the convex piece for the shunt NK cell, and the NK cell is flowed to the edge of convex piece through the convex structure, and the NK cell flows into the inside of feed cover through feed port, filters through filtering conical net, and after filtering through filter screen pipe, enters the rotating ball. BRIEF DESCRIPTION OF DRAWINGS

[0021] The utility model discloses make further detailed explanation to the utility model below combining with the specific embodiment and drawing.

[0022] Fig. 1 It is the structure schematic diagram of the utility model;

[0023] Fig. 2 It is the cross section drawing of the utility model feed cover;

[0024] Fig. 3 It is the rotating ball axle side view of the utility model;

[0025] Fig. 4 It is the buckle plate axle side view of the utility model;

[0026] In the drawing: 1, mixing machine body;2, discharge port;3, adjust feed assembly;3-1, feed cover;3-2, rotating shaft;3-3, rotating ball;3-4, liquid inlet groove;3-5, output motor;3-6, motor table;3-7, limit axle;3-8, limit ball;4, feed filter assembly;4-1, convex piece;4-2, feed port;4-3, filtering conical net;4-4, filter screen pipe;4-5, through hole;5, wide-mouth collecting cover;6, buckle plate;7, buckle groove;8, sealing table;9, bending strip;10, bending accommodation groove;11, support leg;12, motor base. DETAILED DESCRIPTION

[0027] The technical scheme in the embodiments of the utility model will be described clearly and completely in combination with the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor are involved in the protection scope of the utility model.

[0028] As Figs. 1-4 The utility model discloses make further detailed explanation to the utility model below combining with the specific embodiment and drawing.

[0029] Mixing machine body, the bottom of mixing machine body is provided with discharge port;

[0030] An adjusting feeding assembly 3 is arranged at the upper end of the mixing machine body 1;

[0031] A feeding filtering assembly 4 is arranged at the top of the mixing machine body 1;

[0032] The adjusting feeding assembly 3 comprises a feeding cover 3-1, the inside of which is provided with a rotating shaft 3-2, one end of which extends out of the feeding cover 3-1, and the inside of the feeding cover 3-1 is provided with a rotating ball 3-3, the side wall of which is provided with liquid inlet grooves 3-4, the number of which is several, and the plurality of liquid inlet grooves 3-4 are uniformly distributed on the rotating ball 3-3, one end of the rotating ball 3-3 is fixedly connected with the rotating shaft 3-2, and one end of the rotating shaft 3-2 is provided with an output motor 3-5, and the bottom of the output motor 3-5 is provided with a motor table 3-6.

[0033] In this embodiment, the mixing machine body 1 is used for the mixing process of NK cells, the discharge port 2 is used for the discharge after mixing, the feeding cover 3-1 is used for the feeding of NK cells, and the output motor 3-5 on the motor table 3-6 can drive the rotating shaft 3-2 to rotate and drive the rotating ball 3-3 to rotate, and the rotating ball 3-3 and the feeding cover 3-1 are in a sealed state, and when the rotating ball 3-3 rotates, the liquid in the liquid inlet grooves 3-4 will be brought into the bottom of the feeding cover 3-1, thereby flowing into the mixing machine body 1, and since the capacity of the liquid inlet grooves 3-4 is fixed, the dosage of the liquid inlet can be obtained by the number of rotations.

[0034] Specifically, the motor table 3-6 is arranged at the upper end of the mixing machine body 1, one end of the rotating ball 3-3 is provided with a limiting shaft 3-7, the limiting shaft 3-7 is provided with a limiting ball 3-8, and the limiting ball 3-8 is embedded in the side wall of the feeding cover 3-1.

[0035] In this embodiment, the limiting ball 3-8 on the limiting shaft 3-7 is embedded in the feeding cover 3-1, which can make the rotating ball 3-3 rotate more stably.

[0036] Further, the feeding filtering assembly 4 comprises a convex sheet 4-1, which is fixedly embedded in the feeding cover 3-1, the edge of the convex sheet 4-1 is provided with a feeding port 4-2, the feeding cover 3-1 is provided with a filtering conical net 4-3, the filtering conical net 4-3 is located at the lower end of the convex sheet 4-1, and the filtering conical net 4-3 is provided with a filtering net tube 4-4.

[0037] In this embodiment, the convex sheet 4-1 is used for shunting NK cells, the NK cells flow to the edge of the convex sheet 4-1 through the convex structure, the NK cells flow into the inside of the feeding cover 3-1 through the feeding port 4-2, are filtered through the filtering conical net 4-3, and enter the rotating ball 3-3 after being filtered through the filtering net tube 4-4.

[0038] Further, the filtering conical net 4-3 is located above the rotating ball 3-3, a through hole 4-5 is formed at the center of the filtering conical net 4-3, and the filtering net tube 4-4 is arranged on the through hole 4-5.

[0039] In the embodiment, the through hole 4-5 is used for fixing the filtering net tube 4-4.

[0040] Further, the upper end of the feeding cover 3-1 is provided with a wide-mouth collecting cover 5, the wide-mouth collecting cover 5 is connected with the feeding cover 3-1, the wide-mouth collecting cover 5 is buckled with a buckle plate 6, the buckle plate 6 is provided with a buckle slot 7, the inside of the buckle slot 7 is provided with a sealing table 8, the buckle plate 6 is provided with a bending strip 9, the side wall of the bending strip 9 is provided with a bending accommodation slot 10, and a plurality of bending accommodation slots 10 are equidistantly arranged on the bending strip 9.

[0041] In the embodiment, the wide-mouth collecting cover 5 is used for increasing the feeding effect of the feeding cover 3-1, the buckle plate 6 is used for buckling the wide-mouth collecting cover 5, the sealing table 8 is sealed and buckled with the wide-mouth collecting cover 5, and the bending strip 9 is used for bending and accommodating the buckle plate 6.

[0042] Further, the rotating ball 3-3 is sealingly embedded between the feeding cover 3-1, the structure of the rotating ball 3-3 is matched with the feeding cover 3-1, the bottom of the mixer body 1 is provided with a plurality of supporting legs 11, the plurality of supporting legs 11 are uniformly distributed on the bottom surface of the mixer body 1, the bottom of the output motor 3-5 is provided with a motor base 12, and the motor table 3-6 is fixedly installed between the motor base 12.

[0043] In the embodiment, the supporting legs 11 are used for supporting the mixer body 1, and the motor base 12 is used for supporting the output motor 3-5.

[0044] When feeding is needed, the convex piece 4-1 is used for distributing NK cells, the NK cells flow to the edge of the convex piece 4-1 through the convex structure, the NK cells flow into the inside of the feeding cover 3-1 through the feeding port 4-2, are filtered through the filtering conical net 4-3, and enter the rotating ball 3-3 after being filtered through the filtering net tube 4-4, the mixer body 1 is used for the mixing process of the NK cells, the discharge port 2 is used for discharging after mixing, the feeding cover 3-1 is used for feeding the NK cells, the output motor 3-5 on the motor table 3-6 can drive the rotating shaft 3-2 to rotate and drive the rotating ball 3-3 to rotate, the rotating ball 3-3 is in a sealing state with the feeding cover 3-1, the liquid in the liquid inlet groove 3-4 is brought into the bottom of the feeding cover 3-1 when the rotating ball 3-3 rotates, and then flows into the mixer body 1, and since the capacity of the liquid inlet groove 3-4 is fixed, the dosage of the liquid can be obtained by the number of rotations.

[0045] The above merely describes the preferred embodiments of the present application, and is not intended to limit the present application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. Regulatable flow rate mixing device for the combined treatment of NK cells with drugs, characterized in that, The utility model provides a kind of mixing machine, including mixing machine body (1), the bottom of mixing machine body (1) is provided with discharge port (2);Adjusting feed assembly (3) is provided in the upper end of mixing machine body (1);Feed filter assembly (4) is provided in the top of mixing machine body (1);The adjusting feed assembly (3) includes feed cover (3-1), the inside of feed cover (3-1) is provided with rotating shaft (3-2), one end of rotating shaft (3-2) extends feed cover (3-1), the inside of feed cover (3-1) is provided with rotating ball (3-3), the lateral wall of rotating ball (3-3) is provided with liquid inlet groove (3-4), the number of liquid inlet groove (3-4) is several, multiple liquid inlet groove (3-4) is evenly distributed on rotating ball (3-3), one end of rotating ball (3-3) is fixedly connected with rotating shaft (3-2), one end of rotating shaft (3-2) is provided with output motor (3-5), the bottom of output motor (3-5) is provided with motor table (3-6). The motor table (3-6) is provided in the upper end of the mixing machine body (1), one end of the rotating ball (3-3) is provided with a limiting shaft (3-7), the limiting shaft (3-7) is provided with a limiting ball (3-8), and the limiting ball (3-8) is embedded in the side wall of the feed cover (3-1). The feed filter assembly (4) includes a convex sheet (4-1) fixedly embedded in the feed cover (3-1), a feed port (4-2) is opened at the edge of the convex sheet (4-1), a filter conical net (4-3) is provided in the feed cover (3-1), the filter conical net (4-3) is located at the lower end of the convex sheet (4-1), and a filter mesh tube (4-4) is provided on the filter conical net (4-3). The filter conical net (4-3) is located above the rotating ball (3-3), a through hole (4-5) is opened at the center of the filter conical net (4-3), and the filter mesh tube (4-4) is provided on the through hole (4-5). The upper end of the feed cover (3-1) is provided with a wide-mouth collection cover (5) in communication with the feed cover (3-1).

2. The adjustable flow rate mixing device for combination therapy of NK cells and drugs according to claim 1, characterized in that, A buckle plate (6) is buckled on the wide-mouth collection cover (5), a buckle slot (7) is opened on the buckle plate (6), and a sealing table (8) is provided in the buckle slot (7).

3. The adjustable flow rate mixing device for combination therapy of NK cells and drugs according to claim 1, characterized in that, A bending strip (9) is provided on the buckle plate (6), a bending accommodation slot (10) is opened on the side wall of the bending strip (9), and multiple bending accommodation slots (10) are equidistantly opened on the bending strip (9).

4. The adjustable flow rate mixing device for use in combination therapy of NK cells and drugs according to claim 3, characterized in that, The rotating ball (3-3) is sealingly embedded between the feed cover (3-1), and the structure of the rotating ball (3-3) is matched with the feed cover (3-1).

5. The adjustable flow rate mixing device for use in combination therapy of NK cells and drugs according to claim 1, wherein, ​ 6. The adjustable flow rate mixing device for use in combination therapy of NK cells and drugs according to claim 5, characterized in that, ​ 7. The adjustable flow rate mixing device for use in combination therapy of NK cells and drugs according to claim 6, characterized in that, ​ 8. The adjustable flow rate mixing device for use in combination therapy of NK cells and drugs according to claim 1, wherein, ​ 9. The adjustable flow rate mixing device for use in combination therapy of NK cells and drugs according to claim 1, wherein, The bottom of the mixing machine body (1) is provided with a plurality of supporting legs (11), and the plurality of supporting legs (11) are uniformly distributed on the bottom surface of the mixing machine body (1).

10. The adjustable flow rate mixing device for use in combination therapy of NK cells and drugs according to claim 1, wherein, The bottom of the output motor (3-5) is provided with a motor base (12), and the motor base (12) is fixedly installed between the motor base (12) and the motor base (12).

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